CN116850078A - 具有内外协同营养和修复头发功效的发用组合物 - Google Patents
具有内外协同营养和修复头发功效的发用组合物 Download PDFInfo
- Publication number
- CN116850078A CN116850078A CN202210312332.8A CN202210312332A CN116850078A CN 116850078 A CN116850078 A CN 116850078A CN 202210312332 A CN202210312332 A CN 202210312332A CN 116850078 A CN116850078 A CN 116850078A
- Authority
- CN
- China
- Prior art keywords
- protein
- hair
- hydrolyzed
- molecular weight
- protein hydrolysate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004209 hair Anatomy 0.000 title claims abstract description 153
- 239000000203 mixture Substances 0.000 title claims abstract description 43
- 230000002195 synergetic effect Effects 0.000 title claims abstract description 15
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 12
- 230000035764 nutrition Effects 0.000 title claims abstract description 9
- 230000000694 effects Effects 0.000 title abstract description 18
- 239000003531 protein hydrolysate Substances 0.000 claims abstract description 55
- 108010009736 Protein Hydrolysates Proteins 0.000 claims abstract description 38
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims abstract description 32
- 229960003237 betaine Drugs 0.000 claims abstract description 19
- 102000035118 modified proteins Human genes 0.000 claims abstract description 18
- 108091005573 modified proteins Proteins 0.000 claims abstract description 18
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims abstract 7
- 235000018102 proteins Nutrition 0.000 claims description 57
- 102000004169 proteins and genes Human genes 0.000 claims description 57
- 108090000623 proteins and genes Proteins 0.000 claims description 57
- VFKZECOCJCGZQK-UHFFFAOYSA-M 3-hydroxypropyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCO VFKZECOCJCGZQK-UHFFFAOYSA-M 0.000 claims description 14
- 108010076876 Keratins Proteins 0.000 claims description 14
- 102000011782 Keratins Human genes 0.000 claims description 14
- 241000209140 Triticum Species 0.000 claims description 14
- 235000021307 Triticum Nutrition 0.000 claims description 14
- 235000007164 Oryza sativa Nutrition 0.000 claims description 12
- 235000009566 rice Nutrition 0.000 claims description 12
- 239000000654 additive Substances 0.000 claims description 11
- 230000000996 additive effect Effects 0.000 claims description 11
- 108010073771 Soybean Proteins Proteins 0.000 claims description 10
- 229940001941 soy protein Drugs 0.000 claims description 10
- 102000008186 Collagen Human genes 0.000 claims description 8
- 108010035532 Collagen Proteins 0.000 claims description 8
- 229920001436 collagen Polymers 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 5
- ROSDSFDQCJNGOL-UHFFFAOYSA-N protonated dimethyl amine Natural products CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 244000144725 Amygdalus communis Species 0.000 claims description 2
- 235000011437 Amygdalus communis Nutrition 0.000 claims description 2
- 240000006162 Chenopodium quinoa Species 0.000 claims description 2
- 108010084695 Pea Proteins Proteins 0.000 claims description 2
- 244000061456 Solanum tuberosum Species 0.000 claims description 2
- 235000002595 Solanum tuberosum Nutrition 0.000 claims description 2
- 239000005018 casein Substances 0.000 claims description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims description 2
- 235000021240 caseins Nutrition 0.000 claims description 2
- 235000012343 cottonseed oil Nutrition 0.000 claims description 2
- 235000019702 pea protein Nutrition 0.000 claims description 2
- 241000209094 Oryza Species 0.000 claims 4
- 235000021118 plant-derived protein Nutrition 0.000 claims 1
- 239000002453 shampoo Substances 0.000 description 42
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 20
- 239000000047 product Substances 0.000 description 16
- 238000012360 testing method Methods 0.000 description 16
- -1 polydimethylsiloxane Polymers 0.000 description 15
- 239000000284 extract Substances 0.000 description 13
- 231100000640 hair analysis Toxicity 0.000 description 13
- 230000006872 improvement Effects 0.000 description 12
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 11
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 11
- 210000003780 hair follicle Anatomy 0.000 description 11
- 230000003750 conditioning effect Effects 0.000 description 10
- 239000004615 ingredient Substances 0.000 description 10
- 239000011734 sodium Substances 0.000 description 10
- 229910052708 sodium Inorganic materials 0.000 description 10
- 229940083542 sodium Drugs 0.000 description 10
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 9
- 238000002073 fluorescence micrograph Methods 0.000 description 9
- 238000002372 labelling Methods 0.000 description 9
- 239000003921 oil Substances 0.000 description 9
- 235000019198 oils Nutrition 0.000 description 9
- 239000012071 phase Substances 0.000 description 9
- 210000004761 scalp Anatomy 0.000 description 9
- 240000007594 Oryza sativa Species 0.000 description 8
- 108010082495 Dietary Plant Proteins Proteins 0.000 description 7
- 235000011187 glycerol Nutrition 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- 238000005406 washing Methods 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 6
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 230000035515 penetration Effects 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 206010044625 Trichorrhexis Diseases 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000003755 preservative agent Substances 0.000 description 5
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 235000010469 Glycine max Nutrition 0.000 description 4
- 244000068988 Glycine max Species 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 230000001804 emulsifying effect Effects 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000003550 marker Substances 0.000 description 4
- 229940101267 panthenol Drugs 0.000 description 4
- 235000020957 pantothenol Nutrition 0.000 description 4
- 239000011619 pantothenol Substances 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 229920002545 silicone oil Polymers 0.000 description 4
- 229940057950 sodium laureth sulfate Drugs 0.000 description 4
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 3
- YLZOPXRUQYQQID-UHFFFAOYSA-N 3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]propan-1-one Chemical compound N1N=NC=2CN(CCC=21)CCC(=O)N1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F YLZOPXRUQYQQID-UHFFFAOYSA-N 0.000 description 3
- 235000018185 Betula X alpestris Nutrition 0.000 description 3
- 235000018212 Betula X uliginosa Nutrition 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229920002385 Sodium hyaluronate Polymers 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 239000004359 castor oil Substances 0.000 description 3
- 235000019438 castor oil Nutrition 0.000 description 3
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000004043 dyeing Methods 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 239000006260 foam Substances 0.000 description 3
- 229930182478 glucoside Natural products 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 3
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 3
- 229960002216 methylparaben Drugs 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 229960005323 phenoxyethanol Drugs 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 229940010747 sodium hyaluronate Drugs 0.000 description 3
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- 235000010356 sorbitol Nutrition 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 239000003981 vehicle Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- CCLARULDIPFTCP-BOYHRMMASA-N (2r,3r,4r,5s)-heptane-1,2,3,4,5,6-hexol Chemical compound CC(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO CCLARULDIPFTCP-BOYHRMMASA-N 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
- KZRXPHCVIMWWDS-AWEZNQCLSA-N (4S)-4-amino-5-dodecanoyloxy-5-oxopentanoic acid Chemical compound CCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC(O)=O KZRXPHCVIMWWDS-AWEZNQCLSA-N 0.000 description 2
- NKJOXAZJBOMXID-UHFFFAOYSA-N 1,1'-Oxybisoctane Chemical compound CCCCCCCCOCCCCCCCC NKJOXAZJBOMXID-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 2
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 2
- OVBJJZOQPCKUOR-UHFFFAOYSA-L EDTA disodium salt dihydrate Chemical compound O.O.[Na+].[Na+].[O-]C(=O)C[NH+](CC([O-])=O)CC[NH+](CC([O-])=O)CC([O-])=O OVBJJZOQPCKUOR-UHFFFAOYSA-L 0.000 description 2
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 206010019049 Hair texture abnormal Diseases 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- 240000007817 Olea europaea Species 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 229960000458 allantoin Drugs 0.000 description 2
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- 238000004061 bleaching Methods 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 2
- 229940071160 cocoate Drugs 0.000 description 2
- 230000003766 combability Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 2
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000004945 emulsification Methods 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- SHZIWNPUGXLXDT-UHFFFAOYSA-N ethyl hexanoate Chemical compound CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 229940107131 ginseng root Drugs 0.000 description 2
- 150000008131 glucosides Chemical class 0.000 description 2
- 229960005150 glycerol Drugs 0.000 description 2
- 238000009499 grossing Methods 0.000 description 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 2
- QWTDNUCVQCZILF-UHFFFAOYSA-N isopentane Chemical compound CCC(C)C QWTDNUCVQCZILF-UHFFFAOYSA-N 0.000 description 2
- 229940119170 jojoba wax Drugs 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
- 229940071085 lauroyl glutamate Drugs 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 238000001000 micrograph Methods 0.000 description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 2
- BOUCRWJEKAGKKG-UHFFFAOYSA-N n-[3-(diethylaminomethyl)-4-hydroxyphenyl]acetamide Chemical compound CCN(CC)CC1=CC(NC(C)=O)=CC=C1O BOUCRWJEKAGKKG-UHFFFAOYSA-N 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 229940049964 oleate Drugs 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 229940100460 peg-100 stearate Drugs 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 229920001289 polyvinyl ether Polymers 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 229940048109 sodium methyl cocoyl taurate Drugs 0.000 description 2
- 229940032094 squalane Drugs 0.000 description 2
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- 229930003799 tocopherol Natural products 0.000 description 2
- 235000010384 tocopherol Nutrition 0.000 description 2
- 229960001295 tocopherol Drugs 0.000 description 2
- 239000011732 tocopherol Substances 0.000 description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- FKKAGFLIPSSCHT-UHFFFAOYSA-N 1-dodecoxydodecane;sulfuric acid Chemical compound OS(O)(=O)=O.CCCCCCCCCCCCOCCCCCCCCCCCC FKKAGFLIPSSCHT-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 1
- XYTHHAXRVHHXKO-JIUYZRCGSA-N 18-[(2r,3s,4r,5r)-4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxyoctadecanoic acid;ethanol Chemical compound CCO.COC1O[C@H](CO)[C@@H](OCCCCCCCCCCCCCCCCCC(O)=O)[C@H](O)[C@H]1O XYTHHAXRVHHXKO-JIUYZRCGSA-N 0.000 description 1
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 description 1
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 description 1
- GJVUMEONPPTZEY-UHFFFAOYSA-N 2,3-dihydroxypropyl undec-10-enoate Chemical compound OCC(O)COC(=O)CCCCCCCCC=C GJVUMEONPPTZEY-UHFFFAOYSA-N 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- MQFYRUGXOJAUQK-UHFFFAOYSA-N 2-[2-[2-(2-octadecanoyloxyethoxy)ethoxy]ethoxy]ethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOCCOCCOCCOC(=O)CCCCCCCCCCCCCCCCC MQFYRUGXOJAUQK-UHFFFAOYSA-N 0.000 description 1
- JNYGZAJRVPTELQ-UHFFFAOYSA-N 2-ethylhexanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCC(CC)C(O)=O.CCCCC(CC)C(O)=O.CCCCC(CC)C(O)=O JNYGZAJRVPTELQ-UHFFFAOYSA-N 0.000 description 1
- NKEQOUMMGPBKMM-UHFFFAOYSA-N 2-hydroxy-2-[2-(2-hydroxy-3-octadecanoyloxypropoxy)-2-oxoethyl]butanedioic acid Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CC(O)(C(O)=O)CC(O)=O NKEQOUMMGPBKMM-UHFFFAOYSA-N 0.000 description 1
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 description 1
- OYINQIKIQCNQOX-UHFFFAOYSA-M 2-hydroxybutyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCC(O)C[N+](C)(C)C OYINQIKIQCNQOX-UHFFFAOYSA-M 0.000 description 1
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
- BGRXBNZMPMGLQI-UHFFFAOYSA-N 2-octyldodecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCC(CCCCCCCC)CCCCCCCCCC BGRXBNZMPMGLQI-UHFFFAOYSA-N 0.000 description 1
- RMTFNDVZYPHUEF-XZBKPIIZSA-N 3-O-methyl-D-glucose Chemical compound O=C[C@H](O)[C@@H](OC)[C@H](O)[C@H](O)CO RMTFNDVZYPHUEF-XZBKPIIZSA-N 0.000 description 1
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 1
- 235000019489 Almond oil Nutrition 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- 244000061520 Angelica archangelica Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 1
- 240000001548 Camellia japonica Species 0.000 description 1
- 235000009467 Carica papaya Nutrition 0.000 description 1
- 240000006432 Carica papaya Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
- 235000005320 Coleus barbatus Nutrition 0.000 description 1
- 244000007835 Cyamopsis tetragonoloba Species 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- 239000001534 FEMA 4201 Substances 0.000 description 1
- 241001289529 Fallopia multiflora Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 244000230012 Gleditsia triacanthos Species 0.000 description 1
- 235000013813 Gleditsia triacanthos Nutrition 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 235000001287 Guettarda speciosa Nutrition 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 240000007472 Leucaena leucocephala Species 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 1
- CAHKINHBCWCHCF-UHFFFAOYSA-N N-acetyltyrosine Chemical compound CC(=O)NC(C(O)=O)CC1=CC=C(O)C=C1 CAHKINHBCWCHCF-UHFFFAOYSA-N 0.000 description 1
- BVTHRGZMQHOCOL-UHFFFAOYSA-N OCC(O)(C1(NC(=O)NCNC(=O)NC2(CO)NC(=O)NC2=O)NC(=O)NC1=O)CO Chemical compound OCC(O)(C1(NC(=O)NCNC(=O)NC2(CO)NC(=O)NC2=O)NC(=O)NC1=O)CO BVTHRGZMQHOCOL-UHFFFAOYSA-N 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 244000203593 Piper nigrum Species 0.000 description 1
- 235000008184 Piper nigrum Nutrition 0.000 description 1
- 241000131459 Plectranthus barbatus Species 0.000 description 1
- 108010020346 Polyglutamic Acid Proteins 0.000 description 1
- 229920002701 Polyoxyl 40 Stearate Polymers 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 229920000289 Polyquaternium Polymers 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 240000008976 Pterocarpus marsupium Species 0.000 description 1
- 235000010453 Pterocarpus marsupium Nutrition 0.000 description 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 239000004288 Sodium dehydroacetate Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 102220470372 Thymosin beta-10_K12A_mutation Human genes 0.000 description 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 241001506047 Tremella Species 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 description 1
- 241001135917 Vitellaria paradoxa Species 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- SZYSLWCAWVWFLT-UTGHZIEOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl octadecanoate Chemical compound O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O SZYSLWCAWVWFLT-UTGHZIEOSA-N 0.000 description 1
- GDIOVAXMBXDDGA-UHFFFAOYSA-N [1-chloro-2-(2-chloro-2-phenylethoxy)ethyl]benzene Chemical compound ClC(C1=CC=CC=C1)COCC(C1=CC=CC=C1)Cl GDIOVAXMBXDDGA-UHFFFAOYSA-N 0.000 description 1
- RCYWWJBNPIWJMJ-UHFFFAOYSA-N [4-(hexadecanoyloxymethyl)-5-hydroxy-6-methylpyridin-3-yl]methyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC1=CN=C(C)C(O)=C1COC(=O)CCCCCCCCCCCCCCC RCYWWJBNPIWJMJ-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 239000008168 almond oil Substances 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 108090000637 alpha-Amylases Proteins 0.000 description 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 229940063953 ammonium lauryl sulfate Drugs 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 229960000271 arbutin Drugs 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229940067599 ascorbyl glucoside Drugs 0.000 description 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 229940092738 beeswax Drugs 0.000 description 1
- YSJGOMATDFSEED-UHFFFAOYSA-M behentrimonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCCCCCC[N+](C)(C)C YSJGOMATDFSEED-UHFFFAOYSA-M 0.000 description 1
- 229940036350 bisabolol Drugs 0.000 description 1
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-O carboxymethyl-[3-(dodecanoylamino)propyl]-dimethylazanium Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(O)=O MRUAUOIMASANKQ-UHFFFAOYSA-O 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229920006317 cationic polymer Polymers 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 description 1
- 229940106681 chloroacetic acid Drugs 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 235000017471 coenzyme Q10 Nutrition 0.000 description 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 1
- 235000018597 common camellia Nutrition 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 235000003373 curcuma longa Nutrition 0.000 description 1
- 239000001215 curcuma longa l. root Substances 0.000 description 1
- 229940073499 decyl glucoside Drugs 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- AFABGHUZZDYHJO-UHFFFAOYSA-N dimethyl butane Natural products CCCC(C)C AFABGHUZZDYHJO-UHFFFAOYSA-N 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229940068517 fruit extracts Drugs 0.000 description 1
- 229920000370 gamma-poly(glutamate) polymer Polymers 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 229940075529 glyceryl stearate Drugs 0.000 description 1
- 229940049294 glyceryl stearate se Drugs 0.000 description 1
- 229940100608 glycol distearate Drugs 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 239000008169 grapeseed oil Substances 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 230000003699 hair surface Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- 229960004881 homosalate Drugs 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- HKBCJQLNYLWIML-UHFFFAOYSA-N icosan-9-yl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OC(CCCCCCCC)CCCCCCCCCCC HKBCJQLNYLWIML-UHFFFAOYSA-N 0.000 description 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 1
- 230000003752 improving hair Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 description 1
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 1
- 229960004705 kojic acid Drugs 0.000 description 1
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 1
- 229940001447 lactate Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229940075468 lauramidopropyl betaine Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 229940114937 microcrystalline wax Drugs 0.000 description 1
- 229940105132 myristate Drugs 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- SZUJJDLBXJCDNT-ZCNNSNEGSA-N n-[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]acetamide Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(C)=O SZUJJDLBXJCDNT-ZCNNSNEGSA-N 0.000 description 1
- DVEKCXOJTLDBFE-UHFFFAOYSA-N n-dodecyl-n,n-dimethylglycinate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC([O-])=O DVEKCXOJTLDBFE-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- RGUVUPQQFXCJFC-UHFFFAOYSA-N n-hydroxyoctanamide Chemical compound CCCCCCCC(=O)NO RGUVUPQQFXCJFC-UHFFFAOYSA-N 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- HLERILKGMXJNBU-UHFFFAOYSA-N norvaline betaine Chemical compound CCCC(C([O-])=O)[N+](C)(C)C HLERILKGMXJNBU-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 229940073665 octyldodecyl myristate Drugs 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940056211 paraffin Drugs 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229940097941 polyglyceryl-10 laurate Drugs 0.000 description 1
- 229940061570 polyglyceryl-10 stearate Drugs 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 229940051841 polyoxyethylene ether Drugs 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 229940113124 polysorbate 60 Drugs 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229940078492 ppg-17 Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009145 protein modification Effects 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- 229940095042 pyridoxine dipalmitate Drugs 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 235000005412 red sage Nutrition 0.000 description 1
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 229940057910 shea butter Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229940031688 sodium c14-16 olefin sulfonate Drugs 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 1
- 229940079839 sodium dehydroacetate Drugs 0.000 description 1
- 239000000176 sodium gluconate Substances 0.000 description 1
- 235000012207 sodium gluconate Nutrition 0.000 description 1
- 229940005574 sodium gluconate Drugs 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- 235000019830 sodium polyphosphate Nutrition 0.000 description 1
- 229940102541 sodium trideceth sulfate Drugs 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- KLYDBHUQNXKACI-UHFFFAOYSA-M sodium;2-[2-(2-tridecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O KLYDBHUQNXKACI-UHFFFAOYSA-M 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 1
- UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
- 230000003685 thermal hair damage Effects 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
本发明涉及低分子量的蛋白质水解产物、阳离子改性的蛋白质水解产物和甜菜碱的组合在内外协同营养和修复头发中的用途。本发明还涉及一种具有内外协同营养和修复头发功效的发用组合物,其包含低分子量的蛋白质水解产物、阳离子改性的蛋白质水解产物和甜菜碱的组合。
Description
技术领域
本发明涉及一种具有内外协同营养和修复头发功效的发用组合物,其包含低分子量的蛋白质水解产物、阳离子改性的蛋白质水解产物和甜菜碱的组合。
背景技术
日常生活中,诸多伤害头发的因素对头发表皮和皮质造成了不同程度的损伤,例如,环境恶化(例如,紫外线辐射、环境污染、水质等)、机械损伤/热损伤(例如,梳理、定型、热烫、过度频繁清洗、热吹风机干燥等)、化学处理(例如,染色、漂白、烫发、拉直等)、自然老化以及与日俱增的压力均会加剧头发的受损程度,导致头发因孔隙率增加、断点降低、硫含量降低或多肽链降解等而呈现干枯毛躁、触摸易断、毛发脱落、头皮炎症等问题。因此,头发和头皮的护理成为了人们特别关注的话题,洗护发理念随之不断升级,消费者对洗护发产品的功效需求逐渐强化,更崇尚绿色、天然、环保的产品理念,以及着重于清洁、保湿滋养、强韧发丝、改善头发毛躁感和梳理性、促进头皮健康等多重洗护功效。
目前市售的洗护发产品种类繁多,但大多数含有硅油成分,硅油作为护发调理剂已被广泛使用,例如许多洗护发产品通过硅油、阳离子聚合物等物质在头发表层吸附积聚以形成保护膜,然而仅通过这种物理隔离来改善头发状态的问题是易冲洗掉、持久性差、无法深入头发内部进行修复,并且长期使用势必会降低头发的调理性和柔顺感,致使头发干枯、分叉、失去光泽等。随着洗护发产品的功效升级,各品牌更趋向于采用天然护发成分,例如含蛋白类产品,水解蛋白对头发的角蛋白具有高度亲和性,可通过分子中的众多结合位置和反应基团吸附于头发表面,发挥调理作用,但市售的含蛋白类产品要么仅重视头发护理而忽视了头皮护理,要么无法实现深层修复和持久性调理。因此,针对现有产品的技术缺陷,需要开发天然、由内而外深层修复和持久调理头发等的综合功效俱佳的发用组合物。
附图说明
图1和图2为头发样本的荧光显微镜照片。其中:
图1的(a)-(e)是采用FITC荧光素对实施例1-1中的洗发水A-E中的蛋白进行标记并采用含蛋白标记的洗发水A-E处理头发后所得头发样本的荧光显微镜照片;
图1的(f)-(j)是采用FITC荧光素对实施例2-1中的护发素A-E中的蛋白进行标记并采用含蛋白标记的护发素A-E处理头发后所得头发样本的荧光显微镜照片;
图2的(a)-(d)是采用FITC荧光素对实施例1-2中的洗发水F-I中的蛋白进行标记并采用含蛋白标记的洗发水F-I处理头发后所得头发样本的荧光显微镜照片;
图2的(e)-(h)是采用FITC荧光素对实施例2-2中的护发素F-I中的蛋白进行标记并采用含蛋白标记的护发素F-I处理头发后所得头发样本的荧光显微镜照片。
图3是采用实验组和对照组洗发水A-E处理头发样本后的动态梳理力的测试结果。
图4是采用扫描电子显微镜(SEM)微观观察头发样本的照片。其中:
图4(a)是未经处理的毛鳞片的显微照片;
图4(b)是经实施例1-1的洗发水A处理后的毛鳞片的显微照片;
图4(c)是经实施例2-1的护发素A处理后的毛鳞片的显微照片;
图4(d)是经实施例1-1的洗发水B处理后的毛鳞片的显微照片;
图4(e)是经实施例2-1的护发素E处理后的毛鳞片的显微照片。
发明内容
一方面,本发明涉及低分子量的蛋白质水解产物、阳离子改性的蛋白质水解产物和甜菜碱的组合在内外协同营养和修复头发中的用途。
又一方面,本发明涉及一种用于内外协同营养和修复头发的添加剂包,其由用低分子量的蛋白质水解产物、阳离子改性的蛋白质水解产物和甜菜碱组成。
另一方面,本发明提供了一种具有内外协同营养和修复头发功效的发用组合物,其包含低分子量的蛋白质水解产物、阳离子改性的蛋白质水解产物和甜菜碱的组合。
再一方面,本发明提供了一种内外协同营养和修复头发的方法,其包括向头发施用一种发用组合物,其中所述发用组合物包含低分子量的蛋白质水解产物、阳离子改性的蛋白质水解产物和甜菜碱的组合。
本发明人发现,所述甜菜碱不仅对头发和头皮的护理效果良好,而且更能有效促进蛋白渗透,结果是,与单独使用各组分相比,低分子量的蛋白质水解产物、阳离子改性的蛋白质水解产物和甜菜碱的组合提供了显著增强的修复受损发质的功效,这表明所述组合中的各组分产生了协同或增效作用。
所述低分子量的蛋白质水解产物也称为“微蛋白”,其一方面能够滋养皮肤角质层,改善皮肤强度,另一方面具有渗透、强韧、修复、调理、重塑纤维、改善发感等多重作用,其分子量小故容易渗透进发丝内部,穿透毛鳞片渗入皮质,由内而外滋养头发纤维,并能吸附在头发表皮层,强化毛鳞片,增强头发塑性。
所述低分子量的蛋白质水解产物的分子量通常为约100-3000Da,优选地约250-2000Da,更优选约500-1500Da。
所述低分子量的蛋白质水解产物可以是植物、动物、海洋生物或合成源的蛋白质水解产物。在本发明中,优选植物来源的蛋白质水解产物(即,植物微蛋白),其实例包括但不限于低分子量的水解大豆蛋白、水解燕麦蛋白、水解甜杏仁蛋白、水解棉籽蛋白、水解小麦蛋白、水解大米蛋白、水解藜麦蛋白、水解豌豆蛋白、水解马铃薯蛋白等中的一种或多种,优选水解大豆蛋白、水解大米蛋白和水解小麦蛋白等中的一种或多种。本发明中所采用的低分子量的蛋白质水解产物可商购获得,其通常为液体,例如可获自BASF、CRODA等供应商。
所述低分子量的蛋白质水解产物在所述发用组合物中的含量可以为约0.05-20%,优选地约0.1-10%,更优选约0.5-5%,基于所述发用组合物的总重量。
所述阳离子改性的蛋白质水解产物为季铵化的蛋白质水解产物,其具有蛋白质等天然类物的调理性以及季铵盐的吸附性这双重特性,从而增强头发的保湿性、光泽度、干湿梳理性、柔软性以及滑爽性,以达到修复受损发质的功效。所述季铵化的蛋白质水解产物可通过将植物来源或动物来源的蛋白质水解产物借助本领域已知的技术进行季铵化阳离子改性而获得。其实例包括但不限于月桂基二甲基铵羟丙基水解小麦蛋白、月桂基二甲基铵羟丙基水解胶原蛋白、月桂基二甲基铵羟丙基水解角蛋白、月桂基二甲基铵羟丙基水解大豆蛋白、羟丙基三甲基氯化铵水解小麦蛋白、羟丙基三甲基氯化铵水解酪蛋白、羟丙基三甲基氯化铵水解胶原、羟丙基三甲基氯化铵水解角蛋白、羟丙基三甲基氯化铵水解米糠蛋白、羟丙基三甲基氯化铵水解大豆蛋白、椰油基二甲基铵羟丙基水解胶原、椰油基二甲基铵羟丙基水解角蛋白、椰油基二甲基铵羟丙基水解大米蛋白、椰油基二甲基铵羟丙基水解小麦蛋白、椰油基二甲基铵羟丙基水解蚕丝氨基酸类、硬脂基二甲基铵羟丙基水解蚕丝蛋白、硬脂基二甲基铵羟丙基水解胶原、硬脂基二甲基铵羟丙基水解角蛋白等中的一种或多种,优选椰油基二甲基铵羟丙基水解角蛋白、月桂基二甲基铵羟丙基水解角蛋白、月桂基二甲基铵羟丙基水解小麦蛋白、羟丙基三甲基氯化铵水解大豆蛋白等中的一种或多种。所述季铵化的蛋白质水解产物可商购获得,其通常为液体,例如可获自BASF、CRODA等供应商。
所述季铵化的蛋白质水解产物在所述发用组合物中的含量通常为约0.05-20%,优选地约0.1-10%,更优选约0.1-5%,基于所述发用组合物的总重量。在所述季铵化的蛋白质水解产物为动物来源的某些实施方案中,所述季铵化的蛋白质水解产物的含量通常为约0.1-1%,优选0.1-0.6%。
所述甜菜碱亦称为三甲基甘氨酸,分子式为C5H11NO2,为白色结晶性粉末,易溶于水,其可利用已知的提取技术获得,例如,可从天然植物的根、茎、叶及果实中提取或采用三甲胺和氯乙酸为原料化学合成。在本发明中,甜菜碱优选为天然来源,因为其生物降解性好,符合消费者们对绿色、天然、草本的追求。所述甜菜碱可商购获得,例如可获自DuPont等供应商。
所述甜菜碱在所述发用组合物中的含量可以为约0.01-20%,优选约0.05-15%,更优选约0.1-8%,基于所述发用组合物的总重量。
本发明的具有内外协同营养和修复头发功效的发用组合物还任选包含发用产品中常用的成分,其实例包括但不限于活性成分、媒介物、表面活性剂和辅料等本领域已知的任何成分,这些是本领域技术人员已知的,且可根据需要具体选择其类型和用量。
所述活性成分是本领域已知和常用的任何活性物质,其包括但不限于头皮调理剂、头发调理剂等。
所述头皮调理剂给头皮提供滋润、保湿、控油等功效,其实例包括但不限于甘油三(乙基己酸)酯、辛酸/癸酸甘油三酯、牛油果树果脂、鲸蜡醇、聚二甲基硅氧烷、季戊四醇四(乙基己酸)酯、葡萄籽油、白池花籽油、山茶花籽油、橄榄油、玉米油、向日葵籽油、毛瑞榈果油、霍霍巴油、碳酸二辛酯、胡莫柳酯、硬脂醇、角鲨烷、辛基十二醇肉豆蔻酸酯、肉豆蔻醇、氢化聚癸烯、异十六烷、羊毛脂、石蜡、微晶蜡、蜂蜡、桦树汁、甘油、双甘油、丙二醇、1,2-戊二醇、丁二醇、双丙甘醇、异戊二醇、聚乙二醇-8、聚乙二醇-32、甲基葡糖醇聚醚-10、甲基葡糖醇聚醚-20、PEG/PPG-17/6共聚物、甘油聚醚-7、甘油聚醚-26、甘油葡糖苷、PPG-10甲基葡糖醚、PPG-20甲基葡糖醚、PEG/PPG/聚丁二醇-8/5/3甘油、泛醇、蔗糖、海藻糖、鼠李糖、甘露糖、棉子糖、赤藓醇、木糖醇、山梨(糖)醇、尿素、甘油聚醚-5乳酸酯、透明质酸钠、水解透明质酸钠、乙酰化透明质酸钠、聚谷氨酸钠、水解小核菌胶、出芽短梗酶多糖、银耳多糖、酸豆籽多糖、植物甾醇/辛基十二醇月桂酰谷氨酸酯、乙酰植物鞘氨醇、神经酰胺、胆甾醇、曲酸、抗坏血酸、抗坏血酸葡糖苷、尿囊素、氢化卵磷脂、熊果苷、传明酸、烟酰胺、乙酰酪氨酸、生育酚(维生素E)、燕麦仁提取物、泛醌、红没药醇、吡哆素二辛酸酯、吡哆素二棕榈酸酯、视黄醇棕榈酸酯、白藜芦醇、白桦树皮提取物、花榈木树皮提取物、毛喉鞘蕊花根提取物、胡椒籽提取物等中的一种或多种。在本发明组合物中,所述头皮调理剂占所述常用的成分的总重量的约0.01-50%。
所述头发调理剂的实例包括但不限于脂肪醇、甾醇、脂肪酸、氨基酸(例如,丝氨酸、甘氨酸、谷氨酸、丙氨酸等)、单甘油酯、三甘油脂、羊毛脂、肌氨酸酯、脂肪酸酯、白油、角鲨烷、聚季铵盐-10、聚季铵盐-7、聚季铵盐-39、聚季铵盐-52、聚季铵盐-73、瓜尔胶羟丙基三甲基氯化铵、山嵛基三甲基氯化铵、聚二甲基硅油、PEG-60杏仁油甘油酯、泛醇、聚乙烯吡咯烷酮、明胶、果胶、皂荚提取物、丹参提取物、当归根提取物、何首乌提取物、扁柏叶提取物、姜黄根提取物、人参根提取物、三七根提取物、木瓜果提取物、燕麦多肽等中的一种或多种。在本发明组合物中,所述头发调理剂占所述常用的成分的总重量的约0.01-50%。
所述媒介物是本领域已知的,包括但不限于稀释剂、分散剂或载体等,其实例包括但不限于水、乙醇、双丙甘醇、丁二醇等。本领域技术人员可根据需要选择其类型和用量。在本发明组合物中,所述媒介物占所述常用的成分的总重量的约0.5-20%。
所述表面活性剂可以是常用于发用产品的任何类型的表面活性剂,其用于降低界面的表面张力,从而达到清洁、乳化、稳定体系之目的。其实例包括但不限于椰油酰胺丙基甜菜碱、月桂醇聚醚硫酸酯钠、PEG-150二硬脂酸酯、乙二醇二硬脂酸酯、月桂基聚氧乙烯醚硫酸铵、十二烷基醇醚硫酸钠、棕榈酰胺丙基甜菜碱、甲基椰油酰基牛磺酸钠、椰油酰胺二乙醇胺、十二烷基醚硫酸盐、十二烷基硫酸铵(K12A)、脂肪醇聚乙烯醚硫酸钠(AES)、脂肪醇聚乙烯醚硫酸铵(AESA)、月桂基三甲基氯化铵、月桂醇硫酸铵、月桂醇硫酸钠、十二烷基聚醚硫酸铵、椰油基单乙醇酰胺、N-脂肪酰基氨基酸盐、月桂酰胺丙基甜菜碱、椰油酰两性基乙酸钠、月桂酰两性基乙酸钠、月桂醇聚氧乙烯醚硫酸钠、脂肪醇聚氧乙烯醚硫酸钠、十二烷基硫酸钠、烷基糖苷、十二烷基二甲基甜菜碱、咪唑啉两性二醋酸二钠、椰油基两性醋酸钠、PPG-3辛基醚、聚季铵盐-7、聚季铵盐-10、聚季铵盐-37、羟丙基三甲基氯化铵瓜尔胶等中的一种或多种。本领域技术人员可根据需要选择其类型和用量。在本发明组合物中,所述表面活性剂占所述常用的成分的总重量的约0.01-50%。
所述辅料包括但不限于增泡剂、乳化剂、增稠剂、防腐剂、螯合剂、香料、pH调节剂等。
所述增泡剂的实例包括但不限于月桂醇聚醚硫酸酯钠、十三烷醇聚醚硫酸钠、癸基葡糖苷、月桂酰肌氨酸钠、C14-16烯烃磺酸钠、椰子油酸单乙醇酰胺、椰子油酸二乙醇酰胺、椰油酰胺丙基甜菜碱、月桂醇硫酸酯铵、椰油酰两性基乙酸钠等中的一种或多种。在本发明组合物中,所述增泡剂占所述常用的成分的总重量的约0.01-50%。
所述乳化剂的实例包括但不限于鲸蜡硬脂醇橄榄油酸酯、山梨坦橄榄油酸酯、聚山梨醇酯-60、聚山梨醇酯-80、甲基葡糖倍半硬脂酸酯、PEG-20甲基葡糖倍半硬脂酸酯、PEG-40氢化蓖麻油、PPG-26-丁醇聚醚-26、PEG-4聚甘油-2硬脂酸酯、PEG-60氢化蓖麻油、硬脂醇聚醚-2、硬脂醇聚醚-21、PPG-13-癸基十四醇聚醚-24、鲸蜡硬脂基葡糖苷、甘油硬脂酸酯/PEG-100硬脂酸酯、甘油硬脂酸酯、甘油硬脂酸酯SE、椰油基葡糖苷、鲸蜡硬脂醇聚醚-25、PEG-40硬脂酸酯、聚甘油-3甲基葡糖二硬脂酸酯、甘油硬脂酸酯柠檬酸酯、聚甘油-10硬脂酸酯、聚甘油-10肉豆蔻酸酯、聚甘油-10二油酸酯、聚甘油-10月桂酸酯、聚甘油-10异硬脂酸酯、聚甘油-10油酸酯、聚甘油-10二异硬脂酸酯、聚甘油-6月桂酸酯、聚甘油-6肉豆蔻酸酯、蔗糖硬脂酸酯、蔗糖多硬脂酸酯等中的一种或多种。在本发明组合物中,所述乳化剂占所述常用的成分的总重量的约0.01-30%。
所述增稠剂的实例包括但不限于卡波姆、黄原胶、阿拉伯胶、聚乙二醇-14M、聚乙二醇-90M、琥珀酰聚糖、羟乙基纤维素、羟丙基纤维素、丙烯酸(酯)类及其衍生物等中的一种或多种。在本发明组合物中,所述增稠剂占所述常用的成分的总重量的约0.1-10%。
所述防腐剂的实例包括但不限于羟苯甲酯、羟苯乙酯、羟苯丙酯、苯氧乙醇、苯甲醇、苯乙醇、双(羟甲基)咪唑烷基脲、山梨酸钾、苯甲酸钠、氯苯甘醚、脱氢乙酸钠、辛酰羟肟酸等中的一种或多种,以及其它的防腐增效剂,例如1,2-戊二醇、1,2-己二醇、对羟基苯乙酮、辛甘醇、乙基己基甘油、山梨坦辛酸酯、甘油十一碳烯酸酯、甘油辛酸酯等。在本发明组合物中,所述防腐剂占所述常用的成分的总重量的约0.01-10%。
所述螯合剂的实例包括但不限于EDTA二钠、多聚磷酸钠、偏磷酸钠、葡萄糖酸钠等中的一种或多种。本领域技术人员可根据需要具体选择其类型和用量。
所述pH调节剂的实例包括但不限于柠檬酸、柠檬酸钠、精氨酸、乳酸、乳酸钠、氢氧化钠、氢氧化钾、三乙醇胺等中的一种或多种。本领域技术人员可根据需要具体选择其类型和用量。
本发明的发用组合物可通过本领域已知的任何合适的方法制备。例如,可使用日用品领域中常用的溶解槽、乳化锅、分散器、输送泵等设备,根据本领域已知的工艺,进行制备。
例如,制备时可先将水溶性物质投入水相溶解釜,将油溶性物质投入油相溶解釜,分别将两个釜的温度加热至约80℃,其中对于易结块的原料,可先采用分散器将其预分散。待溶解完成后,将油相和水相递送至乳化锅中,均质乳化约5-15分钟。待乳化完成后,将料体温度降至常温,任选地,加入香精、防腐剂等,并视需要调节产物的pH值。待相关检测指标均合格后,方可灌装出货。
以上制备方法可根据剂型要求进行删减或调整。可根据需要制备成液体、乳液、膏、霜或凝胶等各种剂型的发用组合物,其中所述发用组合物可以是洗去型、留存型等洗护发组合物类型,且可以是洗发水、护发素、护发喷雾、护发乳液、护发精华、发膜等各种形式。
实施例
以下结合实施例,对本发明进行进一步详细说明。应当理解为,此处所描述的具体实施例仅例举说明了本发明的技术方案,而不应理解为用于以任何形式限制本发明所附权利要求书的范围。所有类似的替换和改动对本领域技术人员来说是显而易见的,其均被视为包括在本发明的范围内。
实施例1-1:制备实验组与对照组的洗发水样品
在本实施例中,分别制备了具有下述配方的洗发水样品,其中洗发水A为本发明的洗发水,洗发水B-E为对照组样品。
*购自BASF的来自大豆和大米的水解植物蛋白
上述洗发水A-E的制备工序如下所述:
1.水相:将去离子水、甜菜碱、甘油、泛醇、尿囊素、水解透明质酸钠、甲基椰油酰基牛磺酸钠、月桂酰两性基乙酸钠、椰油酰胺丙基甜菜碱、聚季铵盐-10、山梨(糖)醇、甘油聚醚-26、EDTA二钠、羟苯甲酯混合后加热至80℃,搅拌溶解均匀;
2.油相:将乙二醇二硬脂酸酯、甘油硬脂酸酯/PEG-100硬脂酸酯、PPG-3辛基醚、PEG-60氢化蓖麻油混合后加热至80℃,搅拌溶解均匀;
3.将水相和油相混合后搅拌15分钟,加入柠檬酸调节pH,搅拌均匀后降温冷却至40℃,最后加入苯氧乙醇、烟酰胺、香精、水解植物蛋白、椰油基二甲基铵羟丙基水解角蛋白,得到洗发水A-E,其均为无色澄清液体。
实施例1-2:制备另一组实验组的洗发水样品
在本实施例中,与实施例1-1类似地分别制备了具有下述配方的洗发水F-I,其均为本发明的洗发水样品。
*购自BASF的来自大豆和大米的水解植物蛋白
实施例2-1:制备实验组与对照组的护发素样品
在本实施例中,分别制备了具有下述配方的护发素样品,其中护发素A为本发明的护发素,护发素B-E为对照组样品。
*购自BASF的来自大豆和大米的水解植物蛋白
上述护发素A-E的制备工序如下所述:
1.水相:将桦树汁、甜菜碱、泛醇、鲸蜡醇、异戊二醇、透明质酸钠、山梨(糖)醇、月桂基三甲基氯化铵、卡波姆、羟乙基纤维素、羟苯甲酯混合后加热至80℃,搅拌溶解均匀;
2.油相:将辛基十二醇肉豆蔻酸酯、霍霍巴油、植物甾醇/辛基十二醇月桂酰谷氨酸酯、生育酚(维生素E)混合后加热至80℃,搅拌溶解均匀;
3.将水相和油相混合后均质乳化5分钟,乳化完成后,降温冷却至40℃,加入苯氧乙醇、烟酰胺、香精、水解植物蛋白、椰油基二甲基铵羟丙基水解角蛋白,得到护发素A-E,其均为白色膏体。
实施例2-2:制备另一组实验组的护发素样品
在本实施例中,与实施例2-1类似地分别制备了具有下述配方的护发素F-I,其均为本发明的护发素样品。
*购自BASF的来自大豆和大米的水解植物蛋白
实施例3:实验组和对照组样品的头发渗透性能评估
根据下述测试方法,评估上述制备的洗发水A-E和F-I以及护发素A-E和F-I的头发渗透性能。
实验原理:激光共聚焦荧光显微镜是采用激光作为光源,对光源进行过滤,提供特定波长,作为荧光标记物激发的合适波长,使荧光标记发出可见光。首先将荧光标记物(例如,FITC荧光素)吸附在所要研究分子的基团上(例如,蛋白质),然后采用含有标记蛋白的洗发水(或护发素)配方来处理头发,最后将头发冲洗并自然晾干,利用荧光显微镜来检测头发样本上标记蛋白的位置/渗透性。
实验材料:测试材料包括水解植物蛋白、椰油基二甲基铵羟丙基水解角蛋白、月桂基二甲基铵羟丙基水解小麦蛋白、羟丙基三甲基氯化铵水解大豆蛋白、FITC(异硫氰酸荧光素)、DMSO以及PBS pH 7.4缓冲液;测试对象为漂白头发;测试样品包括上述实施例中制备的9种洗发水A-I和9种护发素A-I。
实验步骤:
实验结果显示在图1和图2中。其中,图1中的(a)-(e)是采用FITC荧光素对实施例1-1中的洗发水A-E中的蛋白进行标记并采用含蛋白标记的洗发水A-E处理头发后所得头发样本的荧光显微镜照片;以及图1中的(f)-(j)是采用FITC荧光素对实施例2-1中的护发素A-E中的蛋白进行标记并采用含蛋白标记的护发素A-E处理头发后所得头发样本的荧光显微镜照片。
图2中的(a)-(d)是采用FITC荧光素对实施例1-2中的洗发水F-I中的蛋白进行标记并采用含蛋白标记的洗发水F-I处理头发后所得头发样本的荧光显微镜照片;图2中的(e)-(h)是采用FITC荧光素对实施例2-2中的护发素F-I中的蛋白进行标记并采用含蛋白标记的护发素F-I处理头发后所得头发样本的荧光显微镜照片。
图1的结果表明,与对照组洗发水B-E相比,采用本发明的洗发水A处理头发时,蛋白渗透进发丝的功效更加显著;同样的,与对照组护发素B-E相比,采用本发明的护发素A处理头发时,蛋白渗透进发丝的功效更加显著;这表明,低分子量的蛋白质水解产物、阳离子改性的蛋白质水解产物和甜菜碱的组合在修复受损发质功效上显示了协同或者增效作用。
图2的结果进一步表明,所述阳离子改性的蛋白质水解产物可以采用动物来源或植物来源的,采用本发明的洗发水F-H和护发素F-H处理头发时,蛋白渗透进发丝的功效显著,从而表明了更好的营养和护发功效。
实施例4:实验组和对照组样品的头发梳理性测试
实验原理:梳理力(Required Combing Force,简称RCF),单位为牛顿(N),是指头发对梳子的摩擦阻力,梳理力越小,表明头发顺滑度越好。头发梳理性测试是指在头发干湿两种状态下,通过头发动态梳理性测试仪来模拟消费者洗发过程中各阶段用梳子进行梳理时所遇到的摩擦阻力及阻力的变化情况,以此判断洗护发产品的梳理性能的好坏。
实验仪器及材料:测试仪器为头发梳理性检测仪;测试对象为发束(特定长度和重量);测试样品为实施例1-1制备的5种洗发水A-E。
实验步骤:
实验结果显示在图3中,包括采用5种洗发水A-E处理头发样本后分别测试泡沫阶段、冲洗阶段、湿发阶段和干发阶段的梳理力。图3的结果表明,与对照组洗发水B-E相比,采用本发明的洗发水A处理头发时,在泡沫阶段和冲洗阶段的梳理力差异不大,而在湿发阶段和干发阶段的梳理力明显降低,表明头发的顺滑度明显提高。
实施例5:扫描电子显微镜(SEM)微观观察
实验原理:通过扫描电子显微镜(SEM)照片微观观察实验组和对照组样品的头发毛鳞片的修复状况。
实验材料:测试对象为发束(受损亚洲人毛发);测试样品为上述本发明洗发水A和对照组洗发水B以及本发明护发素A和对照组护发素E。
实验步骤如下。
实验结果显示在图4中,其显示了用上述样品处理经漂白的受损头发后头发毛鳞片的修复情况,其中,图4(a)是未经处理的毛鳞片的显微照片,显示了较多毛鳞片翘起和区域裂缝现象;图4(b)是经实施例1-1的本发明洗发水A处理后的毛鳞片的显微照片,显示了毛鳞片明显被抚平,头发得到明显修复,图4(d)中的经实施例1-1的对照组洗发水B处理后的毛鳞片几乎无抚平效果;图4(c)是经本发明实施例2-1的护发素A处理后的毛鳞片的显微照片,显示了毛鳞片明显被抚平,头发得到明显修复,而图4(e)经实施例2-1的对照组护发素E处理后的毛鳞片仅有轻微的抚平效果。这些结果充分说明了,本发明的洗发水和护发素能有效调理修复头发,尤其是对化学受损发质(染烫、漂白)具有很好的修复作用,表现在能有效修复毛鳞片、增强头发韧性、调理和滋润发丝。
实施例6:使用效果测试
对比实验组和对照组样品的实际使用效果,测试样品为上述本发明洗发水A和对照组洗发水B以及本发明护发素A和对照组护发素E。
选取30位有烫发、染发等化学受损发质的志愿者,男女不限,分为2组开展测试。第1组的15位志愿者每日使用实施例1-1的本发明洗发水A和实施例2-1的本发明护发素A先后清洗和护理头发1次;第2组的15位志愿者每日使用实施例1-1的对照组洗发水B和实施例2-1的对照组护发素E先后清洗护理头发1次,连续使用1周后,分别从头发顺滑度、头发光泽度、头发抗静电能力、发丝易断现象这4个方面进行评价,按照改善程度不同分为明显改善、较明显改善、有一定改善、无明显改善、完全没有改善。
评价结果显示,第1组13位志愿者(约87%)使用产品后在头发顺滑度、头发光泽度、头发抗静电能力、发丝易断现象这4个方面均发生明显改善,而另外2位志愿者在头发抗静电能力有明显改善且在头发顺滑度、头发光泽度、发丝易断现象这3个方面也有较明显改善。第2组5位志愿者(约33%)使用产品后在头发顺滑度、头发抗静电能力、发丝易断现象这3个方面有较明显改善,7位志愿者(约47%)使用产品后在头发顺滑度、发丝易断现象这2个方面有一定改善,而另外3位志愿者使用产品后认为4个方面均无明显改善。上述结果充分表明了,本发明的洗发水和护发素具有优异的修复发丝的功效。
以上所述实施例的技术方案是本发明优选实施方式,并不构成对所附权利要求书的范围限制。在不脱离本发明原理的前提下还可以进行若干改进和变换,这些改进和变化也应视为在本发明的保护范围内。
Claims (13)
1.一种用于发用组合物的添加剂包,其由用低分子量的蛋白质水解产物、阳离子改性的蛋白质水解产物和甜菜碱组成,其中所述低分子量的蛋白质水解产物的分子量为100-3000Da,优选250-2000Da,更优选500-1500Da。
2.根据权利要求1所述的添加剂包,其中所述低分子量的蛋白质水解产物是植物来源的蛋白质水解产物。
3.根据权利要求2所述的添加剂包,其中所述低分子量的蛋白质水解产物选自水解大豆蛋白、水解燕麦蛋白、水解甜杏仁蛋白、水解棉籽蛋白、水解小麦蛋白、水解大米蛋白、水解藜麦蛋白、水解豌豆蛋白和水解马铃薯蛋白。
4.根据权利要求3所述的添加剂包,其中所述低分子量的蛋白质水解产物选自水解大豆蛋白、水解大米蛋白和水解小麦蛋白中的一种或多种。
5.根据权利要求1-4任一项所述的添加剂包,其中所述低分子量的蛋白质水解产物在所述发用组合物中的含量为0.05-20%,优选0.1-10%,更优选0.5-5%,基于所述发用组合物的总重量。
6.根据权利要求1-5任一项所述的添加剂包,其中所述阳离子改性的蛋白质水解产物为季铵化的蛋白质水解产物。
7.根据权利要求6所述的添加剂包,其中所述阳离子改性的蛋白质水解产物选自月桂基二甲基铵羟丙基水解小麦蛋白、月桂基二甲基铵羟丙基水解胶原蛋白、月桂基二甲基铵羟丙基水解角蛋白、月桂基二甲基铵羟丙基水解大豆蛋白、羟丙基三甲基氯化铵水解小麦蛋白、羟丙基三甲基氯化铵水解酪蛋白、羟丙基三甲基氯化铵水解胶原、羟丙基三甲基氯化铵水解角蛋白、羟丙基三甲基氯化铵水解米糠蛋白、羟丙基三甲基氯化铵水解大豆蛋白、椰油基二甲基铵羟丙基水解胶原、椰油基二甲基铵羟丙基水解角蛋白、椰油基二甲基铵羟丙基水解大米蛋白、椰油基二甲基铵羟丙基水解小麦蛋白、椰油基二甲基铵羟丙基水解蚕丝氨基酸类、硬脂基二甲基铵羟丙基水解蚕丝蛋白、硬脂基二甲基铵羟丙基水解胶原和硬脂基二甲基铵羟丙基水解角蛋白中的一种或多种。
8.根据权利要求7所述的添加剂包,其中所述阳离子改性的蛋白质水解产物选自椰油基二甲基铵羟丙基水解角蛋白、月桂基二甲基铵羟丙基水解角蛋白、月桂基二甲基铵羟丙基水解小麦蛋白和羟丙基三甲基氯化铵水解大豆蛋白中的一种或多种。
9.根据权利要求1-8任一项所述的添加剂包,其中所述阳离子改性的蛋白质水解产物在发用组合物中的含量为0.05-20%,优选地0.1-10%,更优选0.1-5%,基于所述发用组合物的总重量。
10.根据权利要求1-9任一项所述的添加剂包,其中所述甜菜碱在所述发用组合物中的含量为0.01-20%,优选0.05-15%,更优选0.1-8%,基于所述发用组合物的总重量。
11.一种具有内外协同营养和修复头发功效的发用组合物,其包含低分子量的蛋白质水解产物、阳离子改性的蛋白质水解产物和甜菜碱的组合,其中所述低分子量的蛋白质水解产物的分子量为100-3000Da,优选250-2000Da,更优选500-1500Da。
12.低分子量的蛋白质水解产物、阳离子改性的蛋白质水解产物和甜菜碱的组合在内外协同营养和修复头发中的用途,其中所述低分子量的蛋白质水解产物的分子量为100-3000Da,优选250-2000Da,更优选500-1500Da。
13.一种内外协同营养和修复头发的方法,其包括向头发施用一种发用组合物,其中所述发用组合物包含低分子量的蛋白质水解产物、阳离子改性的蛋白质水解产物和甜菜碱的组合,其中所述低分子量的蛋白质水解产物的分子量为100-3000Da,优选250-2000Da,更优选500-1500Da。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210312332.8A CN116850078A (zh) | 2022-03-28 | 2022-03-28 | 具有内外协同营养和修复头发功效的发用组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210312332.8A CN116850078A (zh) | 2022-03-28 | 2022-03-28 | 具有内外协同营养和修复头发功效的发用组合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN116850078A true CN116850078A (zh) | 2023-10-10 |
Family
ID=88229129
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202210312332.8A Pending CN116850078A (zh) | 2022-03-28 | 2022-03-28 | 具有内外协同营养和修复头发功效的发用组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN116850078A (zh) |
-
2022
- 2022-03-28 CN CN202210312332.8A patent/CN116850078A/zh active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7377813B2 (ja) | 毛髪改質組成物およびその方法 | |
JP5506786B2 (ja) | 持続性保湿組成物 | |
CN103987369B (zh) | 增强毛发纤维的方法 | |
CN108391419A (zh) | 低聚酯铵盐和它们在化妆品组合物中的用途 | |
KR20160065954A (ko) | 디히드록시알킬 치환된 폴리갈락토만난, 및 그의 제조 및 사용 방법 | |
CA2621334A1 (en) | Shampoo containing a gel network | |
JP7159052B2 (ja) | パーソナルケア組成物及び該組成物の使用方法 | |
EA013329B1 (ru) | Косметически приемлемая композиция и способ обработки субстрата | |
EP3233025B1 (de) | Haarbehandlungsmittel, enthaltend mindestens ein saures protein sowie mindestens ein salz | |
CA3017613A1 (en) | Color protecting, and styling compositions comprising an aptac/mapldmac/acrylate terpolymer or tetrapolymer | |
CA2840145A1 (en) | Personal care composition for reducing surface friction of hair fibres | |
AU2009259418A1 (en) | Composition | |
CN109715128A (zh) | 毛发处理组合物 | |
JP7214359B2 (ja) | レチノイドと低刺激性ポリマー洗浄剤とを含む局所組成物 | |
US6110450A (en) | Hair care compositions comprising ceramide | |
JP4716476B2 (ja) | 頭髪用リンス | |
CN116850078A (zh) | 具有内外协同营养和修复头发功效的发用组合物 | |
DE102010062155A1 (de) | Haarbehandlungsmittel | |
JP6655299B2 (ja) | 毛髪化粧料組成物 | |
JP7294642B2 (ja) | 毛髪化粧料 | |
WO2021083616A1 (en) | Hair care composition | |
WO2012076585A1 (de) | Haarbehandlungsmittel yaconwurzel extrakt enthaltend | |
JP7069207B2 (ja) | 毛髪成形材料 | |
JP5960500B2 (ja) | 毛髪用化粧料 | |
DE102010062615A1 (de) | Haarbehandlungsmittel |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination |