CN116840461A - Shooting device for multiple immunity analyzer and automatic analysis system - Google Patents

Abstract

The application relates to the technical field of medical instruments, in particular to a shooting device and an automatic analysis system for a multiple immunity analyzer. The shooting device comprises a first light emitting module with a first heating part; an imaging module having a second heat generating portion; the refrigerating module comprises a first heat exchange flow channel and a second heat exchange flow channel, the first heating part is positioned on the heat exchange circulation path of the first heat exchange flow channel, and the second heating part is positioned on the heat exchange circulation path of the second heat exchange flow channel; a first air outlet side of a first cold runner of the first heat exchange runner extends towards the first heating part and is provided with a first guide plate, and an extension line of the first guide plate is tangent to or separated from the first heating part; the second air outlet of the second cold runner of the second heat exchange runner is arranged towards the second heating part. The accuracy of the shooting result of the shooting device is guaranteed, and the cooling and refrigerating efficiency is improved.

Description

Shooting device for multiple immunity analyzer and automatic analysis system

Technical Field

The application relates to the technical field of medical instruments, in particular to a shooting device and an automatic analysis system for a multiple immunity analyzer.

Background

With the development and application of in-vitro diagnosis medical technology, in-vitro diagnosis becomes an important auxiliary means for disease diagnosis, and automatic diagnosis equipment is becoming more and more popular with society. According to the detection principle, the automatic diagnosis apparatus can be divided into a nucleic acid detection apparatus and a protein detection apparatus, wherein the protein detection apparatus comprises a chemiluminescent analyzer, an enzyme immunoassay analyzer, a colloidal gold analyzer, an immunochromatography analyzer and a multiplex immunoassay analyzer. The multiple immunity analyzer applies multiple liquid phase chip analysis method to detect liquid phase chips of different groups coded by laser, then connects the identification substance combined with the target substance in the sample to the liquid phase chip by chemical crosslinking, adds the marking substance with fluorescent signal after the target substance in the sample is combined with the corresponding identification substance on the coding surface of the specific liquid phase chip, photographs and identifies the positions of different coded liquid phase chips in bright field, photographs and determines the fluorescent signal corresponding to each liquid phase chip in dark field, converts the fluorescent intensity of the liquid phase chip into the concentration of the corresponding target substance, and further obtains qualitative or quantitative result. The multiplex immunity analyzer comprises a preprocessing device and a shooting device for detecting objects to be detected, wherein the shooting device comprises a bright field shooting piece and a bright field light source which are positioned in an imaging module of the multiplex immunity analyzer, and a dark field shooting piece and a dark field excitation light source which are positioned in a darkroom module of the multiplex immunity analyzer.

However, in the conventional multiple immunity analyzer, after photographing is performed by using photographing equipment continuously, the bright field photographing element and the bright field light source in the imaging module are used continuously for multiple times, so that the temperatures of the light source and the photographing element are easily increased, elements are easily burnt, deviation of photographing results is easily caused, the photographing elements are required to be cooled, but the structure of cooling is improper, water mist or water drops and the like are caused to appear in the photographing lens, the photographing lens is blurred, and the photographing result is influenced.

Disclosure of Invention

The application aims to provide a shooting device and an automatic analysis system applied to the shooting device, so as to ensure the accuracy of shooting results of the shooting device and improve the cooling and refrigerating efficiency.

In a first aspect, the present application provides a photographing apparatus for a multiplex immunoassay analyzer, comprising:

a first light emitting module including a first heat emitting part;

an imaging module including a second heat generating portion;

the refrigeration module comprises a first heat exchange flow channel and a second heat exchange flow channel, the first heating part is positioned on a heat exchange circulation path of the first heat exchange flow channel, and the second heating part is positioned on a heat exchange circulation path of the second heat exchange flow channel;

the first heat exchange flow channel comprises a first hot flow channel, a first alternating current channel and a first cold flow channel which are sequentially communicated, a first guide plate is arranged on the first air outlet side of the first cold flow channel in an extending mode towards the first heating part, and an extension line of the first guide plate is tangent to or separated from the first heating part;

the second heat exchange flow channel comprises a second hot flow channel, a second alternating current channel and a second cold flow channel which are communicated in sequence, and a second air outlet of the second cold flow channel is arranged towards the second heating part.

Further, the first guide plate is located at the lower side edge of the first air outlet, the first guide plate is obliquely upwards arranged, and an included angle alpha formed by the first guide plate and the first alternating current channel is more than or equal to 70 degrees and less than or equal to 90 degrees.

Furthermore, the upper and lower opposite sides of the second air outlet are respectively provided with a second guide plate and a third guide plate in an extending mode, the second guide plates and the third guide plates are mutually inclined and are arranged at intervals, and an included angle beta formed by extension lines of the second guide plates and the third guide plates meets the requirement that beta is more than or equal to 60 degrees and less than 180 degrees.

Further, the first hot runner is positioned below the first guide plate,

the second hot runner is positioned above the second guide plate;

the first hot runner and the second hot runner share the same hot runner;

the first communication channel and the second communication channel are positioned in the same communication cavity.

Further, the axis of the same hot runner shared by the first hot runner and the second hot runner is vertical to the axis of the same circulation cavity where the first communication channel and the second communication channel are located.

Further, one side of the circulation cavity is provided with the first air outlet and the second air outlet, and the other side of the circulation cavity opposite to the first air outlet is provided with a first refrigeration part opposite to the first air outlet and a second refrigeration part opposite to the second air outlet;

the vertical axial height difference from the upper edge of the first refrigeration part to the lower edge of the second refrigeration part is a first axial height;

the distance between the central axis of the first cold runner and the central axis of the second cold runner is greater than one half of the first axial height and less than the first axial height.

Further, the shooting device further comprises a second light-emitting module, wherein the second light-emitting module comprises a first shell and a sliding cover mechanism arranged at the upper end of the first shell;

the first shell comprises a reaction container supporting seat, a light source arranged above the reaction container supporting seat in a ring manner, and a diffuse reflection plate arranged in the same axial direction with the light source;

the top cover is arranged above the first shell, and a reflecting plate is arranged in the direction of the top cover towards the first shell.

Further, a first through hole and a first groove are formed in the center of the reaction container supporting seat, the first through hole and the first groove are coaxially arranged, and the radius of the first groove is larger than that of the first through hole;

the reaction vessel is characterized in that a limiting guide block is arranged in the first groove, a second through hole is formed in the center of the limiting guide block, the second through hole and the first through hole are coaxial and have equal diameters, the upper surface of the limiting guide block is higher than the upper surface of the reaction vessel supporting seat, and the limiting guide block and the first groove are in interference fit.

Further, a reaction container placing seat is arranged below the reaction container supporting seat, a third through hole is formed in the center of the reaction container placing seat, and the aperture of the third through hole is gradually reduced;

the reaction container supporting seat is clamped in the reaction container placing seat and moves synchronously with the reaction container placing seat;

the third through hole, the first through hole and the second through hole are coaxially arranged.

In a second aspect, the present application provides an automatic analysis system comprising a camera for a multiplex immunoassay analyzer as defined in any one of the preceding claims.

Compared with the prior art, in the shooting device provided by the application, the refrigerating module is opened to perform heat exchange, the hot air is rolled away, the cold air is blown out, the burning loss of elements such as the shooting module and the first light-emitting module is effectively prevented, and the accuracy of shooting results is ensured. And to the main parts that generate heat of camera module and first luminous module, first portion that generates heat and second portion that generates heat, specifically can be light source and camera, make first portion that generates heat and second portion that generates heat be located the heat exchange circulation path of the first heat exchange runner of refrigeration module respectively, with the heat exchange circulation path of second heat exchange runner on, further pertinence cooling plays better cooling refrigeration effect. Preferably, the first heat exchange flow channel comprises a first hot flow channel, a first alternating current channel and a first cold flow channel which are sequentially communicated, a first guide plate is arranged on the first air outlet side of the first cold flow channel in an extending way towards the first heating part, and the extension line of the first guide plate is tangent to or separated from the first heating part; the second heat exchange flow passage comprises a second hot flow passage, a second alternating current passage and a second cold flow passage which are communicated in sequence, and a second air outlet of the second cold flow passage is arranged towards the second heating part. The arrangement is that not only the first air outlet and the second air outlet are correspondingly arranged towards the first heating part and the second heating part respectively, but also the objective lens at the uppermost part is avoided, the main heating part is accelerated and cooled more specifically, the refrigerating effect is improved, and the cooling time is shortened; and the arrangement of the first guide plate increases the guiding property of blowing out cold air, improves the utilization rate of the cold air, reduces waste, and ensures that the effective area of the first heating part is larger and the cooling efficiency is higher.

Drawings

In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present application, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.

Fig. 1 is a schematic diagram of an overall structure of a photographing device according to an embodiment of the present application;

fig. 2 is a schematic diagram of an internal structure of a photographing apparatus according to an embodiment of the present application;

fig. 3 is a schematic airflow diagram of a refrigeration module according to an embodiment of the present disclosure;

fig. 4 is a side view of an internal structure of a photographing apparatus according to an embodiment of the present application;

fig. 5 is a schematic structural diagram of a refrigeration module according to an embodiment of the present application;

fig. 6 is a cut-away perspective view of a refrigeration module according to an embodiment of the present application;

fig. 7 is a schematic diagram of a baffle structure of a refrigeration module according to an embodiment of the present application;

fig. 8 is a schematic view illustrating an internal structure of another angle of the photographing apparatus according to an embodiment of the present application;

fig. 9 is an exploded view of a second light emitting module according to an embodiment of the present application;

fig. 10 is a cross-sectional view of a photographing apparatus according to an embodiment of the present application;

FIG. 11 is a schematic structural diagram of a fixing base according to an embodiment of the present application;

FIG. 12 is a schematic view showing a structure of a reaction vessel holder according to an embodiment of the present application;

fig. 13 is a schematic structural diagram of a lampshade according to an embodiment of the present application;

fig. 14 is a schematic structural diagram of a limiting guide block according to an embodiment of the present application.

Reference numerals:

10-a housing;

11-top plate;

12-a bottom plate;

13-struts;

21-an objective lens;

22-a first light emitting module;

221-a first heating section;

a 23-camera module;

231-a second heat generating part;

30-a refrigeration module;

311-a first air outlet;

312-a second air outlet;

321-a first deflector;

322-a second baffle;

323-a third deflector;

33-a hot runner;

331-a refrigeration fan;

34-a flow-through cavity;

341-upper holder;

342-lower mount;

343-a fixing plate;

3431-insulating layer;

3432-refrigeration fins;

344-side plates;

345-condensed water outlet;

346-a first temperature sensor;

351-a first refrigeration unit;

352-a second refrigeration unit;

361-a first heat dissipation fan;

3611-a first radiator fan fixing plate;

3612-first heat radiating fins;

362-a second radiator fan;

3621-a second radiator fan fixing plate;

3622-second heat radiating fins;

40-focusing module;

41-a bracket;

42-a first motor;

43-screw rod;

44-a fixing piece;

50-a second light emitting module;

51-a slider driving mechanism;

511-a second motor;

512-a driving wheel;

513-driven wheel;

514-belt;

515-slider;

5151-a light shielding sheet;

516-slide rail;

52-a first housing;

521-photoelectric sensor;

522-diffuse reflection plate;

53-a slider mechanism;

541-top cover;

5411-reflecting plates;

542-a support ring;

543-a light source;

544-reaction vessel support;

5441-first through holes;

5442-first groove;

545-limiting guide block;

5451-second through holes;

5452-first fixing holes;

5453-first threaded hole;

55-fixing seat;

551-second groove;

552-a shooting slot;

553, placing a groove;

554-an elastic member;

561-reaction vessel placement base;

5611-a third through hole;

562-a platen;

563-optical filter.

Detailed Description

For the purpose of making the objects, technical solutions and advantages of the embodiments of the present application more apparent, the technical solutions of the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application, and it is apparent that the described embodiments are some embodiments of the present application, but not all embodiments of the present application. The components of the embodiments of the present application generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the application, as presented in the figures, is not intended to limit the scope of the application, as claimed, but is merely representative of selected embodiments of the application. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.

It should be noted that: like reference numerals and letters denote like items in the following figures, and thus once an item is defined in one figure, no further definition or explanation thereof is necessary in the following figures.

In the description of the present application, it should be noted that, directions or positional relationships indicated by terms such as "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., are directions or positional relationships based on those shown in the drawings, or those that are conventionally put in use of the product of the application, are merely for convenience of describing the present application and simplifying the description, and do not indicate or imply that the apparatus or elements referred to must have a specific direction, be configured and operated in a specific direction, and thus should not be construed as limiting the present application. Furthermore, the terms "first," "second," "third," and the like are used merely to distinguish between descriptions and should not be construed as indicating or implying relative importance.

Furthermore, the terms "horizontal," "vertical," "overhang," and the like do not denote a requirement that the component be absolutely horizontal or overhang, but rather may be slightly inclined. As "horizontal" merely means that its direction is more horizontal than "vertical", and does not mean that the structure must be perfectly horizontal, but may be slightly inclined.

In the description of the present application, it should also be noted that, unless explicitly specified and limited otherwise, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present application will be understood in specific cases by those of ordinary skill in the art.

Some embodiments of the present application are described in detail below with reference to the accompanying drawings. The following embodiments and features of the embodiments may be combined with each other without conflict.

As shown in fig. 1 to 7, an embodiment of the present application provides a photographing device for a multiple immune analyzer and an automatic analysis system, where the photographing device is used for photographing and detecting an object to be detected, such as a liquid chip. The photographing device comprises a first light emitting module 22, a photographing module 23 and a refrigerating module 30, wherein the first light emitting module 22 comprises a first heating part 221, and the first heating part 221 can be mainly provided with a light source; the camera module 23 includes a second heat generating portion 231, where the second heat generating portion 231 may be specifically a position where a camera is disposed; as shown in fig. 3, the refrigeration module 30 includes a first heat exchange flow path and a second heat exchange flow path, the first heat generating part 221 is located on the heat exchange circulation path of the first heat exchange flow path, and the second heat generating part 231 is located on the heat exchange circulation path of the second heat exchange flow path; the first heat exchange flow channel comprises a first hot flow channel, a first alternating current channel and a first cold flow channel which are sequentially communicated, a first air outlet 311 side of the first cold flow channel extends towards the first heating part 221 to be provided with a first guide plate 321, and an extension line of the first guide plate 321 is tangent to or separated from the first heating part 221; the second heat exchange flow passage includes a second hot flow passage, a second alternating current passage, and a second cold flow passage that are sequentially communicated, and a second air outlet 312 of the second cold flow passage is disposed toward the second heat generating portion 231.

Compared with the prior art, in the photographing device provided by the embodiment of the application, the refrigerating module 30 is opened to perform heat exchange, the hot air is rolled away, the cold air is blown out, the burning-out of elements such as the photographing module 23, the first light-emitting module 22 and the like is effectively prevented, and the accuracy of a photographing result is ensured. And for the main heating parts of the camera module 23 and the first light emitting module 22, namely the first heating part 221 and the second heating part 231, the main heating parts can be specifically a light source and a camera, so that the first heating part 221 and the second heating part 231 are respectively positioned on the heat exchange circulation path of the first heat exchange flow channel and the heat exchange circulation path of the second heat exchange flow channel of the refrigeration module 30, and further targeted cooling is performed, thereby playing a better role in cooling and refrigeration. Preferably, the first heat exchange flow channel comprises a first hot flow channel, a first alternating current channel and a first cold flow channel which are sequentially communicated, a first air outlet 311 side of the first cold flow channel extends towards the first heating part 221 to be provided with a first guide plate 321, and an extension line of the first guide plate 321 is tangent to or separated from the first heating part 221; the second heat exchange flow passage includes a second hot flow passage, a second alternating current passage, and a second cold flow passage that are sequentially communicated, and a second air outlet 312 of the second cold flow passage is disposed toward the second heat generating part 231. So arranged, not only the first air outlet 311 and the second air outlet 312 are correspondingly arranged towards the first heating part 221 and the second heating part 231 respectively, but also the lens of the objective lens 21 positioned at the uppermost part is avoided, the main heating part is accelerated and cooled more specifically, the refrigerating effect is improved, and the cooling time is shortened; and the arrangement of the first guide plate increases the guiding property of blowing out cold air, improves the utilization rate of the cold air, reduces waste, and ensures that the effective area of the first heating part is larger and the cooling efficiency is higher.

Further, as shown in fig. 3 to 7, the second air outlet 312 is provided with a second air guiding plate 322 and a third air guiding plate 323 respectively extending from the upper and lower opposite sides thereof, and the second air guiding plate 322 and the third air guiding plate 323 are inclined and spaced from each other. The arrangement of the second guide plate 322 and the third guide plate 323 further increases the guiding property of the blown cold air, improves the utilization rate of the cold air, reduces waste, and ensures that the effective area blown to the second heating part is larger and the cooling efficiency is higher.

The first deflector 321 is located at the lower side of the first air outlet 311, and the first deflector 321 is disposed obliquely upwards, and according to experimental tests, it is preferable that an included angle α formed by the first deflector 321 and the first communication channel is satisfied, and α is greater than or equal to 70 ° and less than 90 °; the included angle beta formed by the extension lines of the second guide plate 322 and the third guide plate 323 is smaller than or equal to 60 degrees and smaller than 180 degrees, so that the set refrigeration effect is better, the refrigeration efficiency is higher, the speed is higher, the definition of the lens of the camera of the second heating part 231 is not affected, and water mist or water drops and the like are not generated. Further, it is preferable that the protruding lengths of the first deflector 321, the second deflector 322, and the third deflector 323 described above be set to be greater than or equal to 10mm.

Preferably, the first hot runner is located below the first deflector 321, and the second hot runner is located above the second deflector 322; preferably, the first hot runner and the second hot runner share the same hot runner 33, and the hot runner 33 may be located between the first flow guiding plate 321 and the second flow guiding plate 322, and the hot runner 33 may be specifically provided with a cooling fan 331; preferably, the first communication channel and the second communication channel may also be located in the same communication cavity 34. Preferably, the axis of the same hot runner 33 shared by the first hot runner and the second hot runner is perpendicular to the axis of the same flow chamber 34 in which the first communication channel and the second communication channel are located.

Further, the first air outlet 311 and the second air outlet 312 may be provided at one side of the circulation cavity 34, and a first refrigerating part 351 opposite to the first air outlet 311 and a second refrigerating part 352 opposite to the second air outlet 312 may be provided at the other side of the circulation cavity 34 opposite thereto; as shown in fig. 4, a vertical axial height difference from an upper edge of the first cooling part 351 to a lower edge of the second cooling part 352 is a first axial height H, and a distance D between a central axis of the first cold runner to a central axis of the second cold runner is greater than one half of the first axial height H and less than the first axial height H.

In a specific embodiment, as shown in fig. 3 to 7, the refrigeration module 30 may be specifically provided with an upper fixing frame 341; a lower mount 342; a fixing plate 343 having a thermal insulation layer 3431 laid thereon, both ends of which are respectively connected to the upper and lower fixing frames 341 and 342; a side plate 344; a cooling fin 3432 fixed to the fixing plate 343; a first cooling unit 351 and a second cooling unit 352 fixed to the cooling fin 3432 and disposed in this order; a first heat dissipating member provided corresponding to the heat generating end of the first refrigerating part 351, and a second heat dissipating member provided corresponding to the heat generating end of the second refrigerating part 352. The first heat dissipation assembly specifically includes a first heat dissipation fan 361, a first heat dissipation fin 3612, and a first heat dissipation fan fixing plate 3611 fixedly installed on the fixing plate 343, the second heat dissipation assembly specifically may include a second heat dissipation fan 362, a second heat dissipation fin 3622, and a second heat dissipation fan fixing plate 3621 fixedly installed on the fixing plate 343, so that heat dissipation is more targeted, heat dissipation effect is better, and the first heat dissipation fan 361 and the second heat dissipation fan 362 are sequentially arranged up and down. Preferably, the insulating layer 3431 is made of an insulating Style material, and preferably, the first and second refrigerating parts 351 and 352 are made of Peltier materials.

Preferably, the side plate 344 and the fixing plate 343 are vertically disposed, a horizontal space is provided between the side plate 344 and the fixing plate 343, and the same flow chamber 34 with the first flow channel and the second flow channel can be surrounded by the side plate 344, the upper fixing frame 341, the lower fixing frame 342 and the fixing plate 343. The bottom of the circulation cavity 34 may further be provided with a condensed water outlet 345, from which the generated condensed water can flow out, and condensed water produced when hot air taking heat away enters the cooling fins 3432 for heat exchange is led out from the condensed water outlet 345, thereby creating a drier shooting environment.

The first air outlet 311, the second air outlet 312, the first baffle 321, the second baffle 322, and the third baffle 323 may be disposed at the position of the side plate 344, and specifically, the first air outlet 311, the hot runner 33, and the second air outlet 312 may be sequentially disposed from top to bottom, the cooling fan 331 is mounted at the position of the hot runner 33, and the air inlet of the cooling fan 331 is directly disposed to the cooling fins 3432 on the fixing plate 343, and the cooling fan 331 directly blows to the cooling fins 3432. Furthermore, a first temperature sensor 346 may be disposed on the side plate 344 below the first baffle 321.

Can be specifically provided withThe rated air volume of the customized cooling fan 331, the first cooling fan 361 and the second cooling fan 362 is 7m ³ And/h, the air outlet interface of the first air outlet 311 and the second air outlet 312 is about 350mm ² The air speed is about 0.05m/s, the first deflector 321 forms an included angle of 70 degrees with the vertical direction at the room temperature of 30 ℃, the second deflector 322 forms an included angle of 60 degrees with the third deflector 323, the sheet metal structures of the first deflector 321, the second deflector 322 and the third deflector 323 extend outwards for 10mm, the refrigeration effect is best under the condition, the time is shortest, the refrigeration speed is fastest, the time is 301 seconds, and the projection area of the second air outlet 312 blown to the lens of the camera on the first heating part is 1050mm at the moment ² Water mist or water drops can not appear, and the definition of the lens can not be influenced.

Under the condition that the rated refrigerating capacity of the first refrigerating unit 351 and the second refrigerating unit 352 is about 50W, the temperature detected by the first temperature sensor 346 is reduced from the room temperature of 30 ℃ to 26+/-0.5 ℃, the temperature fed back by the temperature control point is used as a basis, and the structure with the least temperature consumption is the optimal structure. When the center distance from the position of the air inlet of the cooling fan 331 to the position of the first air outlet 311 and the second air outlet 312 is 50mm, the cooling fan 331 directly blows air to the cooling fins 3432 at the room temperature of 30 ℃, the air speed measured at the first air outlet 311 is about 0.02m/s, and the air speed measured at the second air outlet 312 is about 0.03m/s; the wind speed measured at the air outlets (the first air outlet 311 and the second air outlet 312) was reduced by about 0.01m/s every 60mm of the center distance.

When the included angle between the first deflector 321 and the vertical direction is increased by 10 degrees, the time for decreasing to 26 ℃ is increased by 30-45 s under the same condition than when the included angle between the first deflector 321 and the vertical direction is 70 degrees; when the included angle between the first guide plate 321 and the vertical direction is greater than 90 degrees, the refrigerating effect is basically maintained at about 400 seconds; when the included angle between the first deflector 321 and the vertical direction is 60 degrees, the time for decreasing to 26 ℃ is increased by 25 seconds under the same condition compared with the time for increasing the included angle between the first deflector 321 and the vertical direction by 70 degrees; when the angle between the first deflector 321 and the vertical direction is less than or equal to 50 °, slight water mist appears at the bottom of the inner side of the top plate 11, and the refrigerating time is 416 seconds; when the angle between the first deflector 321 and the vertical direction is further reduced, the air volume of the first air outlet 311 is significantly reduced, and a layer of water mist is generated on the surface of the first deflector 321.

The test was performed under a relatively room temperature environment, in which the first deflector 321 forms an angle of 70 ° with the vertical direction, the second deflector 322 forms an angle of 60 ° with the third deflector 323, and the above experiment was repeated, so that the upper and lower ends of the side plates 344 were found to have different degrees of small water droplets, and the refrigerating time was different from 4 to 8 seconds. Specifically, when the first deflector 321 forms an angle of 70 ° with the vertical direction and the second deflector 322 forms an angle of 60 ° with the third deflector 323, 90% of the generated water droplets can flow back into the refrigerating space and be discharged from the condensed water outlet 345; when the included angle between the second guide plate 322 and the third guide plate 323 is reduced by 10 degrees, the wind speed of the second air outlet 312 is reduced, the projection area of the air outlet of the second air outlet 312 to the second heating part 231 is reduced by about 60%, and the air can only be blown to the part of the camera of the second heating part 231, so that the effective utilization rate is reduced; when the angle between the first guide plate 321 and the vertical direction is reduced, the cold air from the second air outlet 312 blows to the inner side of the top plate 11, so that the inner side of the top plate 11 is cooled, and local small liquid beads can appear on the inner side of the top plate 11 in a relatively room temperature environment.

As shown in fig. 4, in another further embodiment, a horizontal distance between the first air outlet 311 and/or the second air outlet 312 and the longitudinal center axis of the first heat generating part 221 is a first horizontal distance L1, a longitudinal distance between the protruding end of the first baffle 321 and the center point of the first heat generating part 221 is a first height distance H1, and a longitudinal distance between the center position of the second air outlet 312 and the center point of the first heat generating part 221 is a second height distance H2, preferably, the first horizontal distance L1 is greater than or equal to 65.5mm and less than or equal to 75.5mm, and the first height distance H1 is greater than or equal to 11mm and less than or equal to 31mm; the second height distance H2 is greater than or equal to 64.5mm and less than or equal to 84.5mm, so that the refrigerating effect is optimal and the time is shortest.

Specifically, when the first horizontal distance L1 is 70.5mm, the first height distance H1 is 21mm, and the second height distance H2 is 74.5mm, repeated tests are repeated for several times, and the refrigeration under the current structure is performedThe cooling effect of the module 30 is optimal, the time is the shortest about 301 seconds, and the projection area of the second air outlet 312 blowing the air onto the second heating portion 231 is about 1050mm ² The effective utilization rate is higher, and meanwhile, the condensate water is reduced.

The magnitudes of the first horizontal distance L1, the first height distance H1, and the second height distance H2 all have an influence on the cooling effect of the cooling module 30. Specifically, the first horizontal distance L1 affects the horizontal distance from the air outlet to the first heat generating portion 221, and directly affects the cooling capacity acting on the surface of the first heat generating portion 221; the magnitudes of the first height distance H1 and the second height distance H2 affect the location of the refrigeration effective area. When the first horizontal distance L1 increases, the distance from the air outlet to the second heat generating part 231 increases, resulting in a decrease in the amount of cold air acting on the surface of the second heat generating part 231, and a decrease in the cooling effect, and the local temperature of the second heat generating part 231 may be 0.5 ℃ higher than the internal temperature of the photographing device; when the first horizontal distance L1 is reduced, the distance between the second heating portion 231 and the cooling fan 331 is relatively short, so as to block air intake, resulting in a reduction in air volume of the air outlet, and meanwhile, due to the presence of the first deflector 321, if the distance between the second heating portion 231 and the cooling fan 331 is relatively short, cold air of the air outlet cannot fully act on the surface of the second heating portion 231, and at this time, the local temperature of the second heating portion 231 is 0.5 ℃ higher than the internal temperature of the photographing device; when the first height distance H1 and the second height distance H2 are increased or decreased, the position angles of the air outlets of the first deflector 321, the second deflector 322 and the third deflector 323 are affected, so that the cold air is deviated from the first heating portion 221 and the second heating portion 231.

As indicated by arrows in fig. 3, the air direction of the air inlet of the cooling fan 331 is from inside to outside, and the air blown into the cooling fins 3432 from inside the casing 10 enters the circulation cavity 34, and the hot air blown into the casing 10 is involved and subjected to heat exchange, and the cold air is blown out from the first air outlet 311 and the second air outlet 312, and the air directions of the air inlets of the first cooling fan 361 and the second cooling fan 362 are from outside to inside, so as to perform heat dissipation treatment on the heat-generating end of the first cooling portion 351 and the heat-generating end of the second cooling portion 352. Conversely, if the air inlet direction of the cooling fan 331 is changed from inside to outside, the air enters from the first air outlet 311 and the second air outlet 312, and exits from the air inlet of the middle cooling fan 331, the time taken for the temperature detected by the first temperature sensor 346 to decrease from the room temperature 30 ℃ to 26±0.5 ℃ is 620 seconds, the time is greatly increased, and the first air outlet 311 is opposite to the first heating part 221, and water drops are generated on the outer surface of the first heating part 221 under long time, so that the shooting result is affected; and the heat exchange on the cooling fin 3432 is relatively small, so that frost is formed at the root position of the cooling fin 3432. Therefore, the air intake direction of the cooling fan 331 must be from the inside toward the cooling fins 3432. Otherwise, the cooling fan 331 directly blows the first light emitting module 22 and the image capturing module 23, and the rapid flow of air may affect the focusing of the lens of the objective lens 21 above, resulting in a probability of generating virtual focus or identifying an abnormality of the liquid phase chip; and condensed water is easily generated by the convergence of cold and hot air streams, which may cause short circuit of the circuit board, and the condensed water may cause blurring of the lens of the objective lens 21, which may cause focusing failure. Therefore, the embodiment of the present application makes the air guiding plate structure at the first air outlet 311 and the second air outlet 312, so that the air outlet position not only avoids the lens of the objective lens 21, but also provides cold air to the positions of the first heating part 221 and the second heating part 231 of the main heating source.

Further, the refrigerating module 30 may further be provided with a second temperature sensor, and after detecting a temperature increase, the first refrigerating unit 351, the second refrigerating unit 352, the refrigerating fan 331, the first cooling fan 361, and the second cooling fan 362 may adjust their own power according to the temperature condition, so that the internal environment temperature of the photographing device reaches the target temperature as soon as possible, and after the temperature reaches the target temperature, the first refrigerating unit 351, the second refrigerating unit 352, the refrigerating fan 331, the first cooling fan 361, and the second cooling fan 362 may temporarily operate, thereby preventing the temperature from being too low. Specifically, the second temperature sensor may be installed inside the first heat generating portion 221 and the second heat generating portion 231, so that temperature detection is more accurate.

As shown in fig. 1 and 2, the photographing device provided in the embodiment of the present application further includes a housing 10, where the housing 10 is preferably in a square or rectangular structure, and is formed by enclosing and packaging a top plate 11, a bottom plate 12 and four side wall plates, four vertical edges of the housing 10 may be respectively provided with four pillars 13 for supporting the top plate 11 and the bottom plate 12, the photographing module 23 and the focusing module 40 are located in the housing 10 and fixedly mounted on the bottom plate 12, the second light emitting module 50 is located outside the housing 10 and fixedly mounted on the top plate 11 and is correspondingly disposed up and down with the first light emitting module 22 located in the housing 10, the top plate 11 is provided with a interpretation photographing hole, and the second light emitting module 50 and the first light emitting module 22 are correspondingly disposed in up-down communication with each other. After the shooting device is assembled, a relatively airtight space is formed inside the shell 10, particles such as fragments and dust of the belt 514 are reduced, precision instruments such as the first light emitting module 22, the shooting module 23 and the focusing module 40 inside the shell 10 are protected, the overall stability of the shooting device is improved, and the service life of the shooting device is prolonged. And further, in order to increase the interpretation stability and shock resistance, the bottom plate 12 can adopt a counterweight design so as to effectively reduce the influence of shock on imaging and focusing.

In a specific embodiment, the opening on one side wall plate of the housing 10 is disposed corresponding to the positions of the first light emitting module 22 and the image capturing module 23, and the upper fixing frame 341 and the lower fixing frame 342 are fixedly mounted on the upper side and the lower side of the opening, respectively, or the upper fixing frame 341 and the lower fixing frame 342 are fixedly mounted on the top plate 11 and the bottom plate 12 of the housing 10, respectively; the cooling fan 331 fixed to the side plate 344 is located inside the case 10, and the first and second cooling fans 361 and 362 are mounted on the fixing plate 343 and located outside the case 10.

As shown in fig. 1 and 2, an objective lens 21 is installed above the first light emitting module 22, and a focusing module 40 is disposed in the housing 10 and is in driving connection with the objective lens 21, so as to drive the objective lens 21 to perform a lifting motion. Specifically, the focusing module 40 includes a bracket 41 fixed on the base plate 12, a first motor 42 and a guide rail fixed on the bracket 41, a guide block slidably connected to the guide rail, a screw 43 with one end connected to the guide block and the other end connected to the bracket 41, a nut sleeved on the screw 43, a fixing member 44 fixedly connected to the nut, and a lens of the objective lens 21 is fixedly connected to the fixing member 44.

As shown in fig. 1 and 2 and fig. 8 to 10, the aforementioned second light emitting module 50 includes a slide cover driving mechanism 51 fixed on the top plate 11; and a first housing 52 fixed to the top plate 11; a top cover 541 located on top of the first housing 52, the top cover 541 being provided with a reflective plate 5411 toward the first housing 52; a slide cover mechanism 53 which is in driving connection with the slide cover driving mechanism 51 and can horizontally slide above the top cover 541; the first housing 52 includes a support ring 542 fixed to the top cover 541, a reaction vessel support seat 544, a light source 543 disposed above the reaction vessel support seat 544 and surrounding the first housing 52, a diffuse reflection plate 522 disposed coaxially with the light source 543, a reaction vessel placement seat 561 disposed below the reaction vessel support seat 544, a fixing seat 55 disposed below the first housing 52, a filter 563 fixed below the fixing seat 55 for filtering fluorescent noise, and a pressure plate 562 disposed on the fixing seat 55. The light source 543 may be a white light source, and may be a white light lamp. According to the embodiment of the application, the light source 543 can be padded up through the supporting ring 542, so that the lamp beads are suspended, the lamp beads are prevented from being contacted with the reaction container supporting seat 544, and the occurrence of overheat of the lamp beads is reduced.

So set up, light that the light source 543 sent is under the diffuse reflection of aforesaid diffuse reflection board 522, and a part of light can penetrate reaction vessel supporting seat 544 and penetrate the bottom of reaction vessel placing seat 561, namely the bottom of reaction vessel, and another part of light can be through reflector 5411 through top cap 541, reaction vessel supporting seat 544 from the side supplementary light source of reaction vessel for the photo that is taking under the bright field to the liquid phase chip is more clear. In this embodiment, the light source 543 is fixed on the top cover 541 which cannot move, there is no relative movement, and no consideration is required to avoid the problem caused by the slide driving mechanism 51, so in the embodiment of the present application, the top plate 11 may be made into a whole plate, so that a relatively independent space is formed inside the housing 10, and the pollutants generated when the slide driving mechanism 51 drives the slide mechanism 53 to move only fall on the outer side of the top plate 11, and cannot enter the first light emitting module 22 and the camera module 23 in the housing 10, and meanwhile, the influence of dust on the first light emitting module 22 and the camera module 23 is reduced, so that the stability of the device is improved to a certain extent, and the service life of the device is prolonged.

Further, a first through hole 5441 and a first groove 5442 are provided at the center of the reaction container support seat 544, the first through hole 5441 and the first groove 5442 are coaxially disposed, and the radius of the first groove 5442 is larger than the radius of the first through hole 5441; the first groove 5442 is provided with a limiting guide block 545, as shown in fig. 14, a second through hole 5451 is formed in the center of the limiting guide block 545, the second through hole 5451 and the first through hole 5441 are coaxial and have equal diameters, the upper surface of the limiting guide block 545 is higher than the upper surface of the reaction container supporting seat 544, and the limiting guide block 545 and the first groove 5442 are in interference fit. The adjustment of the second light emitting module 50 in the vertical direction may be completed through the limit guide block 545, the limit guide block 545 may be in a cake-shaped structure, the second through holes 5451 are located at the center, and at least two first fixing holes 5452 and at least two first threaded holes 5453 may be uniformly staggered in sequence along the circumference thereof. The fault tolerance rate of the placement of the reaction container can be increased, so that the reaction container is more stable when being placed in the limit guide block 545; and then checking the interpreted imaging, observing the definition of each point to judge whether the longitudinal and horizontal degrees of the interpretation meet the requirements, if partial virtual focus exists, slightly jacking up the limiting guide block 545 by screwing the jackscrew, so that the bottom of the reaction container is relatively parallel to the lens of the objective lens 21, and the bottom of the reaction container is ensured to have no virtual focus.

Further, as shown in fig. 12, a third through hole 5611 is formed in the center of the reaction vessel placement seat 561, and the aperture of the third through hole 5611 is tapered; the reaction container supporting seat 544 is clamped in the reaction container placing seat 561 and moves synchronously with the reaction container placing seat 561; the third through hole 5611 is disposed coaxially with the first through hole 5441 and the second through hole 5451.

Furthermore, a fixing seat 55 is arranged below the first shell 52, a second groove 551 is formed in the fixing seat 55, the reaction container placing seat 561 is placed in the second groove 551, and the radius of the second groove 551 is larger than that of the reaction container placing seat 561; the second groove 551 has a plurality of grooves 553 formed on a wall thereof for accommodating the elastic members 554, the elastic members 554 are abutted against the reaction vessel accommodating seats 561, and the elastic members 554 may be springs. As shown in fig. 11, the fixing base 55 is provided with an inward concave circular area for matching with and placing the reaction container placing base 561, a second groove 551 for placing the optical filter and a shooting groove 552 can be overlapped at the central position of the inward concave circular area, and a third through hole 5611 is correspondingly arranged at the central position in the reaction container placing base 561; the inner side walls of the concave circular areas can be provided with placing grooves 553 for placing elastic pieces 554, and tightening jackscrews can be placed in the placing grooves 553. So arranged, the reaction container placing seat 561 is placed in the fixed seat 55, then the spring is locked with the jackscrew, the spring is not required to be screwed, the function of guiding and supporting the spring is achieved, and the spring is prevented from being flected out; then, the jackscrew is screwed down, the third through hole 5611 of the reaction vessel placement base 561 is placed at the center position of the fixed base 55, and the tightness of screwing down the jackscrew is adjusted by taking a picture until the taken picture is located at the center position of the display. At this time, the pressing plate 562 is locked to the fixing base 55, thereby fixing the reaction vessel placement base 561. This process completes the debugging of the horizontal direction of the second light emitting module 50.

In addition, as shown in fig. 1 and 8, the slide driving mechanism 51 includes a second motor 511 disposed inside the housing 10 and fixed inside the top plate 11, a driving wheel 512 and a driven wheel 513 mounted on the side of the top plate 11, the driving wheel 512 being fixedly connected to an output shaft of the second motor 511, a belt 514 fitted over the driving wheel 512 and the driven wheel 513, a slide rail 516 horizontally disposed and fixed to a side wall of the first housing 52, and a slide block 515 slidably connected to the slide rail 516, and the top and bottom of the slide block 515 are fixedly connected to the slide mechanism 53 and the belt 514, respectively. Preferably, the first housing 52 may further be provided with a photoelectric sensor 521, and the slider 515 may further be provided with a light shielding sheet 5151 provided in cooperation with the photoelectric sensor 521.

Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present application, and not for limiting the same; although the application has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the application.

Claims (10)

1. A photographing device for a multiplex immunoassay analyzer, comprising:

a first light emitting module including a first heat emitting part;

an imaging module including a second heat generating portion;

the refrigeration module comprises a first heat exchange flow channel and a second heat exchange flow channel, the first heating part is positioned on a heat exchange circulation path of the first heat exchange flow channel, and the second heating part is positioned on a heat exchange circulation path of the second heat exchange flow channel;

the first heat exchange flow channel comprises a first hot flow channel, a first alternating current channel and a first cold flow channel which are sequentially communicated, a first guide plate is arranged on the first air outlet side of the first cold flow channel in an extending mode towards the first heating part, and an extension line of the first guide plate is tangent to or separated from the first heating part;

the second heat exchange flow channel comprises a second hot flow channel, a second alternating current channel and a second cold flow channel which are communicated in sequence, and a second air outlet of the second cold flow channel is arranged towards the second heating part.

2. The photographing device of claim 1, wherein,

the first guide plate is positioned on the lower side edge of the first air outlet, the first guide plate is obliquely upwards arranged, and an included angle alpha formed by the first guide plate and the first alternating current channel is more than or equal to 70 degrees and less than 90 degrees.

3. The photographing device of claim 2, wherein,

the upper side and the lower side of the second air outlet are respectively provided with a second guide plate and a third guide plate in an extending mode, the second guide plates and the third guide plates are mutually inclined and are arranged at intervals, and an included angle beta formed by extension lines of the second guide plates and the third guide plates meets 60 degrees or more and less than 180 degrees.

4. The photographing device of claim 3, wherein,

the first hot runner is positioned below the first guide plate,

the second hot runner is positioned above the second guide plate;

the first hot runner and the second hot runner share the same hot runner;

the first communication channel and the second communication channel are positioned in the same communication cavity.

5. The photographing device of claim 4, wherein,

the axis of the same hot runner shared by the first hot runner and the second hot runner is vertical to the axis of the same circulating cavity where the first communication channel and the second communication channel are located.

6. The photographing device of claim 5, wherein,

the first air outlet and the second air outlet are arranged on one side of the circulation cavity, and a first refrigeration part opposite to the first air outlet and a second refrigeration part opposite to the second air outlet are arranged on the other side of the circulation cavity opposite to the first air outlet;

the vertical axial height difference from the upper edge of the first refrigeration part to the lower edge of the second refrigeration part is a first axial height;

the distance between the central axis of the first cold runner and the central axis of the second cold runner is greater than one half of the first axial height and less than the first axial height.

7. The photographing device of claim 1, further comprising a second light emitting module, the second light emitting module comprising a first housing and a slide cover mechanism disposed at an upper end of the first housing;

the first shell comprises a reaction container supporting seat, a light source arranged above the reaction container supporting seat in a ring manner, and a diffuse reflection plate arranged in the same axial direction with the light source;

the top cover is arranged above the first shell, and a reflecting plate is arranged in the direction of the top cover towards the first shell.

8. The photographing device of claim 7, wherein,

a first through hole and a first groove are formed in the center of the reaction container supporting seat, the first through hole and the first groove are coaxially arranged, and the radius of the first groove is larger than that of the first through hole;

the reaction vessel is characterized in that a limiting guide block is arranged in the first groove, a second through hole is formed in the center of the limiting guide block, the second through hole and the first through hole are coaxial and have equal diameters, the upper surface of the limiting guide block is higher than the upper surface of the reaction vessel supporting seat, and the limiting guide block and the first groove are in interference fit.

9. The photographing device of claim 8, wherein,

a reaction container placing seat is arranged below the reaction container supporting seat, a third through hole is formed in the center of the reaction container placing seat, and the aperture of the third through hole is gradually reduced;

the reaction container supporting seat is clamped in the reaction container placing seat and moves synchronously with the reaction container placing seat;

the third through hole, the first through hole and the second through hole are coaxially arranged.

10. An automatic analysis system comprising the photographing device for a multiplex immunoassay analyzer according to any one of claims 1 to 9.