CN116832262A

CN116832262A - Medical multichannel infusion system

Info

Publication number: CN116832262A
Application number: CN202310988324.XA
Authority: CN
Inventors: 陈非凡; 李昊天; 张欢
Original assignee: Tsinghua University
Current assignee: Tsinghua University
Priority date: 2023-08-07
Filing date: 2023-08-07
Publication date: 2023-10-03

Abstract

The present disclosure relates to a medical multi-channel infusion system comprising: a plurality of infusion channels; each infusion channel comprises: the infusion bag pressurizing module, the detecting module and the measuring and controlling module; the infusion bag pressurizing module is used for applying extrusion force to the infusion bag arranged in the infusion channel; the detection module is used for detecting the actual flow value of the flowing liquid in the infusion tube in the infusion channel; the measurement and control module is configured to perform: acquiring a set flow value which is needed to be achieved by liquid in a separate infusion tube in an infusion channel, and acquiring an actual flow value detected currently; and controlling extrusion force applied to the infusion bag by the infusion bag pressurization module in the infusion channel according to the set flow value and the actual flow value, so that the actual flow value of liquid in a split infusion tube connected with the infusion bag reaches the set flow value. Therefore, the common disposable infusion consumable can be used for realizing accurate and rapid infusion of liquid, reducing the economic burden required by infusion, and simultaneously realizing accurate control of the infusion flow and the infusion capacity of the liquid.

Description

Medical multichannel infusion system

Technical Field

The present disclosure relates to the field of medical devices, and in particular, to a medical multi-channel infusion system.

Background

At present, under critical situations of massive blood loss of a human body in a short time in clinical medical treatment, battlefield rescue and disaster rescue situations such as organ transplantation, accurate and rapid infusion of blood and related medical liquids is needed, and at present, common disposable infusion consumables cannot be used for infusion under the situations, and expensive special disposable consumables such as metal pipelines, infusion pumps and the like are needed, so that economic burden required by user infusion is increased.

The contact type special disposable infusion pump can meet the flow requirement of quick infusion, but the contact type special disposable infusion pump needs to be in direct contact with infusion liquid, so that the medical risk is high; while other existing infusion protocols are almost incapable of meeting the flow requirements required for rapid and accurate infusion; in addition, the existing infusion scheme can not realize accurate control of infusion flow and infusion capacity because infusion is stopped and the infusion can be continued after the air bubbles are discharged when abnormal conditions such as air bubbles occur in the infusion process.

Disclosure of Invention

In view of this, this disclosure provides a medical multichannel infusion system, can use ordinary disposable infusion consumptive material to realize the accurate quick infusion of liquid, reduces the required economic burden of infusion, reduces medical risk, can realize simultaneously the accurate control to infusion flow and the infusion capacity of liquid.

According to an aspect of the present disclosure, there is provided a medical multi-channel infusion system, characterized in that the system comprises: a plurality of infusion channels; the disposable infusion consumable comprises infusion bags and a plurality of sub-infusion pipes connected with the infusion bags, wherein liquid flowing in the sub-infusion pipes of the infusion channels is converged into a main infusion pipe through a confluence device, and the tail end of the main infusion pipe is connected with an injection needle; wherein each infusion channel comprises: the infusion bag pressurizing module, the detecting module and the measuring and controlling module; the infusion bag pressurizing modules in each infusion channel are used for applying extrusion force to the infusion bags arranged in the infusion channels, and the extrusion force applied by the infusion bag pressurizing modules to the infusion bags is positively correlated with the flow of liquid in the infusion dividing pipes connected with the infusion bags; the detection module in each infusion channel is used for detecting the actual flow value of the flowing liquid in the infusion tube of each infusion channel; the measurement and control module in each infusion channel is configured to perform: acquiring a set flow value which is needed to be reached by liquid in a separate infusion tube in an infusion channel, and acquiring an actual flow value currently detected by a detection module in the infusion channel; and controlling extrusion force applied to the infusion bag by the infusion bag pressurization module in the infusion channel according to the set flow value and the current detected actual flow value, so that the actual flow value of liquid in the infusion tube connected with the infusion bag reaches the set flow value.

In one possible implementation, the infusion bag pressurization module includes: the infusion bag pressurizer, the air pressure sensor and the air charging and discharging device are connected through an air three-way valve; wherein the infusion bag pressurizer is used for applying extrusion force to the infusion bag; the gas charging and discharging device is used for charging or discharging the infusion bag pressurizer so as to adjust the actual pressure of the gas in the infusion bag pressurizer, and the actual pressure of the gas in the infusion bag pressurizer is positively correlated with the extrusion force applied by the infusion bag pressurizer to the infusion bag; the air pressure sensor is used for detecting the actual air pressure value of the air in the infusion bag pressurizer; wherein the measurement and control module in each infusion channel is configured to perform: acquiring a set flow value which is needed to be reached by liquid in a separate infusion tube in an infusion channel, an actual flow value currently detected by a detection module in the infusion channel and an actual air pressure value currently detected by an air pressure sensor in the infusion channel; and controlling the gas charging and discharging device in the infusion channel to charge or discharge the infusion bag pressurizer according to the set flow value, the current detected actual flow value and the current detected actual air pressure value so as to control the extrusion force applied by the infusion bag pressurizer to the infusion bag and enable the actual flow value of liquid in the infusion tube connected with the infusion bag to reach the set flow value.

In one possible implementation manner, the controlling the gas filling and discharging device in the infusion channel to fill or discharge the infusion bag pressurizer according to the set flow value, the current detected actual flow value and the current detected actual air pressure value includes: determining a set air pressure value to be reached by air in the infusion bag pressurizer according to the flow deviation between the set flow value and the current detected actual flow value; determining a current gas flow set value according to the gas pressure deviation between the set gas pressure value and the current detected actual gas pressure value, wherein the gas flow set value comprises a gas path state and a gas flow, the gas path state is used for indicating whether the gas charging and discharging device charges or discharges, and the gas flow is used for indicating the charging speed or the discharging speed of the gas charging and discharging device; and sending a control signal to the gas charging and discharging device according to the gas flow set value, wherein the control signal is used for controlling the gas charging and discharging device to charge or discharge the infusion bag pressurizer according to the gas flow set value.

In one possible implementation manner, the infusion bag pressurizer is made of flexible materials, and the gas charging and discharging device comprises an electric air valve and a miniature air pump; the electric air valve is used for switching the flow direction of air in the electric air valve according to the air path state indicated by the control signal so as to realize inflation or deflation of the infusion bag pressurizer; the miniature air pump is used for adjusting the inflation speed or the deflation speed according to the air flow indicated by the control signal; the electric air valve comprises a first air valve interface, a second air valve interface, a third air valve interface and a fourth air valve interface; the miniature air pump comprises a first air pump interface and a second air pump interface; the first air valve interface is communicated with the atmosphere, the second air valve interface is communicated with the first air pump interface, the third air valve interface is communicated with the second air pump interface, the fourth air valve interface is communicated with one interface of the air three-way valve, and the other two interfaces of the air three-way valve are respectively communicated with the infusion bag pressurizer and the air pressure sensor; when the gas charging and discharging device performs charging, air in the atmosphere flows to a second air valve interface from a first air valve interface of the electric air valve, then enters the micro air pump from the second air valve interface through a first air pump interface of the micro air pump, then the micro air pump compresses the entering air and forms compressed gas, the compressed gas is output from the second air pump interface of the micro air pump, flows to a fourth air valve interface through a third air valve interface of the electric air valve, and enters the transfusion bag pressurizer from the fourth air valve interface through a gas three-way valve; when the air charging and discharging device executes air discharging, compressed air in the infusion bag pressurizer flows to a fourth air valve interface of the electric air valve from the air three-way valve, flows to a second air valve interface through the fourth air valve interface, then enters the micro air pump from the second air valve interface through a first air pump interface of the micro air pump, compressed air pumped by the micro air pump is output to a third air valve interface of the electric air valve from the second air pump interface of the micro air pump, flows to the first air valve interface through the third air valve interface and enters the atmosphere from the first air valve interface.

In one possible implementation manner, the detection module in each infusion channel is further used for detecting whether bubbles exist in the liquid in the infusion tube and sending a bubble detection result to the measurement and control module in the infusion channel; an exhaust chamber is arranged on the branch infusion tube; also included in each infusion channel is: the flow stop device is used for blocking or conducting the circulation of liquid in the infusion tube; the flow stopper deforms the split infusion tube by applying pressure to the outer wall of the split infusion tube to block liquid circulation, and when the pressure is not applied to the outer wall of the split infusion tube, the liquid in the split infusion tube normally circulates; the measurement and control module in each infusion channel is further configured to perform: under the condition that the bubble detection result sent by the detection module in the infusion channel represents that bubbles exist in the liquid in the infusion tube, controlling the flow stopper in the infusion channel to block the circulation of the liquid in the infusion tube so as to enable the gas in the liquid in the infusion tube to move to and be discharged from the discharge chamber; and controlling the flow stopper in the infusion channel to conduct the circulation of the liquid in the infusion tube under the condition that the bubble detection result sent by the detection module in the infusion channel represents that no bubble exists in the liquid in the infusion tube.

In one possible implementation manner, the flow stop device comprises a clamp and an extrusion assembly, wherein the clamp is used for fixing the sub-infusion tube, and the extrusion assembly is used for blocking or conducting the circulation of liquid in the sub-infusion tube fixed by the clamp; the extrusion assembly in the conducting state has no force with the outer wall of the sub-infusion tube, so that the sub-infusion tube does not deform, and liquid in the sub-infusion tube normally circulates; the extrusion component in the blocking state has a force with the outer wall of the branch infusion tube, so that the branch infusion tube is deformed, and the liquid in the branch infusion tube is blocked for circulation.

In one possible implementation, the measurement and control module of each infusion channel is further configured to perform: acquiring a target flow value set by a user, wherein the target flow value is used for indicating a flow value to be reached by liquid flowing in the main infusion tube; and determining a set flow value to be reached by the liquid in the infusion tube of each infusion channel according to the target flow value and the number of the infusion channels in the system, so that the liquid flow in the main infusion tube reaches the target flow value.

In one possible implementation manner, in the case that a part of abnormal infusion channels stop working in the multiple infusion channels, the measurement and control module in the abnormal infusion channel is further used for sending abnormal information to the rest infusion channels still working normally in the system; the measurement and control module in the remaining infusion channels is further configured to perform: under the condition that abnormal information sent by an abnormal infusion channel is received, determining a new set flow value which is needed to be reached by liquid in a split infusion tube in the residual infusion channel according to the target flow value and the quantity of the residual infusion channels, so that the liquid flow in the main infusion tube keeps the target flow value; and controlling the gas charging and discharging device in the infusion bag pressurizing module to charge or discharge the infusion bag pressurizer according to the new set flow value, the actual flow value currently detected by the detecting module in the residual infusion channel and the actual pressure value of the gas in the infusion bag pressurizer currently detected by the gas sensor in the infusion bag pressurizing module so as to control the extrusion force applied by the infusion bag pressurizer to the infusion bag to enable the actual flow value of the liquid in the infusion tube connected with the infusion bag to reach the new set flow value.

In one possible implementation, the combiner comprises N-1 liquid three-way valves, and an output end of a designated one of the N-1 liquid three-way valves is connected with the main infusion tube; the N-1 liquid three-way valves are used for connecting N sub-infusion tubes corresponding to the N infusion channels in parallel so as to collect the liquid circulating in the N sub-infusion tubes into the main infusion tube, wherein N is a positive integer.

In one possible implementation, the end of each infusion branch pipe is connected with a liquid three-way valve in the confluence device through a medical one-way valve, and the medical one-way valve is used for preventing liquid from flowing back; the infusion bag, the branch infusion tube, the main infusion tube, the injection needle, the medical one-way valve and the confluence device are all common disposable medical consumables.

According to the embodiment of the disclosure, through adopting a plurality of infusion channels, the common disposable infusion consumable material such as the replaceable infusion bag and the infusion tube is arranged in each infusion channel, not only is direct contact infusion liquid unnecessary, but also special medical consumable material is unnecessary, the infusion cost and medical risk are reduced, and the liquid infusion is respectively carried out in parallel by the plurality of infusion channels independently, so that when the infusion channels are abnormal, the liquid infusion operation can still be carried out by other normally working infusion channels, thus the whole liquid infusion operation is not required to be stopped, the actual flow value is acquired through the detection module, the extrusion force applied to the infusion bag by the infusion bag pressurization module is controlled according to the set flow value and the actual flow value, the control of the actual flow value of liquid in the infusion tube is realized, the closed-loop control of the liquid infusion flow can be realized, namely the precise control of the liquid infusion flow is realized, and the precise control of the infusion flow is equivalent to the precise control of the infusion capacity because the infusion capacity is the integral of the infusion flow in time.

Other features and aspects of the present disclosure will become apparent from the following detailed description of exemplary embodiments, which proceeds with reference to the accompanying drawings.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate exemplary embodiments, features and aspects of the present disclosure and together with the description, serve to explain the principles of the disclosure.

Fig. 1 shows a schematic view of a medical multi-channel infusion system according to an embodiment of the present disclosure.

Fig. 2 illustrates a schematic structure of a combiner according to an embodiment of the present disclosure.

Fig. 3 illustrates an application diagram of a medical check valve according to an embodiment of the present disclosure.

Fig. 4 shows a schematic view of a medical multi-channel infusion system according to an embodiment of the present disclosure.

Fig. 5 (a) shows a schematic diagram of the gas flow of a gas charge-discharge device performing charging according to an embodiment of the present disclosure.

Fig. 5 (b) shows a schematic diagram of the gas flow of a gas charge-discharge device performing gas discharge according to an embodiment of the present disclosure.

Fig. 6 illustrates a schematic diagram of a closed loop control process of fluid flow in an infusion channel according to an embodiment of the present disclosure.

Fig. 7 shows a schematic view of a medical multi-channel infusion system according to an embodiment of the present disclosure.

Fig. 8 (a) shows a schematic diagram of a stopper on state according to an embodiment of the present disclosure.

Fig. 8 (b) shows a schematic diagram of a stopper blocking state according to an embodiment of the present disclosure.

Fig. 9 (a) shows a schematic diagram of a stopper and a stopper in an on state according to an embodiment of the present disclosure.

Fig. 9 (b) shows a schematic view of a stopper and stopper in a blocking state according to an embodiment of the present disclosure.

Fig. 10 shows a schematic diagram of an infusion channel bubble exception handling process according to an embodiment of the present disclosure.

Fig. 11 is a schematic structural diagram of a mimo closed-loop measurement and control module according to an embodiment of the present disclosure.

Detailed Description

Various exemplary embodiments, features and aspects of the disclosure will be described in detail below with reference to the drawings. In the drawings, like reference numbers indicate identical or functionally similar elements. Although various aspects of the embodiments are illustrated in the accompanying drawings, the drawings are not necessarily drawn to scale unless specifically indicated.

The word "exemplary" is used herein to mean "serving as an example, embodiment, or illustration. Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments.

In addition, numerous specific details are set forth in the following detailed description in order to provide a better understanding of the present disclosure. It will be understood by those skilled in the art that the present disclosure may be practiced without some of these specific details. In some instances, methods, means, elements, and circuits well known to those skilled in the art have not been described in detail in order not to obscure the present disclosure.

Fig. 1 shows a schematic view of a medical multi-channel infusion system according to an embodiment of the present disclosure. As shown in fig. 1, the medical multi-channel infusion system includes: a plurality of infusion channels (i.e., infusion channel 1 through infusion channel N);

wherein, each infusion channel is provided with replaceable disposable infusion consumable materials, the disposable infusion consumable materials comprise an infusion bag and a split infusion tube connected with the infusion bag, the liquid flowing in the multiple sub-infusion tubes of the multiple infusion channels is converged into a main infusion tube through a confluence device, and the tail end of the main infusion tube is connected with an injection needle;

wherein each infusion channel comprises: an infusion bag pressurizing module 01, a detecting module 02 and a measuring and controlling module 00; the infusion bag pressurizing modules 01 in each infusion channel are used for applying extrusion force to the infusion bags arranged in the infusion channels, and the extrusion force applied by the infusion bag pressurizing modules 01 to the infusion bags is positively correlated with the flow of liquid in the infusion dividing pipes connected with the infusion bags; the detection module 02 in each infusion channel is used for detecting the actual flow value of the flowing liquid in the infusion tube of each infusion channel;

The measurement and control module 00 in each infusion channel is configured to perform: acquiring a set flow value which is needed to be reached by liquid in a separate infusion tube in an infusion channel, and acquiring an actual flow value which is detected currently by a detection module 02 in the infusion channel; and controlling the extrusion force applied to the infusion bag by the infusion bag pressurization module 01 in the infusion channel according to the set flow value and the current detected actual flow value so as to enable the actual flow value of the liquid in the infusion tube connected with the infusion bag to reach the set flow value.

When the medical multi-channel infusion system shown in fig. 1 is used for liquid infusion, a plurality of mutually independent infusion channels in the system can be used for realizing parallel liquid infusion, wherein the infusion channels in the system can realize any number of channel expansion according to the needs, and the internal structure and the infusion operation of each infusion channel in the system are the same and independent. When a user desires to perform liquid infusion using the medical multi-channel infusion system, infusion bags corresponding to the number of channels and sub-infusion tubes connected with the infusion bags may be disposed in the infusion channels, and a confluence device may be connected to the ends of the plurality of sub-infusion tubes, so that the fluid circulated in the plurality of sub-infusion tubes is collected into the main infusion tube by the confluence device, thereby implementing liquid infusion through an injection needle connected with the main infusion tube. Wherein the fluid of the infusion bag may be a fluid to be infused, such as plasma, medicines, etc., embodiments of the present disclosure are not limited in the type of fluid infused.

In practical application, the confluence device may be formed by common disposable medical consumables, that is, the confluence device is also a disposable medical consumable, and exemplarily, fig. 2 shows a schematic structural diagram of the confluence device provided by an embodiment of the disclosure, as shown in fig. 2, N infusion channels correspond to N sub-infusion tubes, the confluence device includes N-1 liquid three-way valves, and an output end of a designated one of the N-1 liquid three-way valves (e.g., a 2 nd liquid three-way valve 2 in fig. 2) is connected to a main infusion tube; the N-1 liquid three-way valves are used for connecting N sub-infusion pipes corresponding to the N infusion channels in parallel so as to collect the liquid circulating in the N sub-infusion pipes into the main infusion pipe, wherein N is a positive integer; wherein, the liquid three-way valves can be connected through a common infusion hose. That is, the confluence device is provided with N input ends which are in butt joint with the sub-infusion pipes of each infusion channel one by one and only one output end which is in butt joint with the main infusion pipe, the sub-infusion pipes of each infusion channel are connected in parallel through the N-1 common medical liquid three-way valve in the confluence device, and then liquid in all the sub-infusion pipes is converged to the main infusion pipe of the output end through the 1 common medical liquid three-way valve.

In practical application, as shown in fig. 3, the end of each infusion tube can be connected to the confluence device through a medical check valve, and the medical check valve can be used for preventing liquid from flowing back; specifically, the tail end of each branch infusion tube is connected with one interface of a liquid three-way valve in the confluence device through a medical one-way valve, so that liquid in a plurality of branch infusion tubes is converged into a main infusion tube, and liquid backflow in the liquid infusion process can be prevented; the medical one-way valve and the liquid three-way valve of the confluence device can be connected through a common infusion hose.

The infusion bag, the branch infusion tube, the main infusion tube, the injection needle, the medical one-way valve and the confluence device (comprising a liquid three-way valve, an infusion hose and the like) used in the liquid infusion process by the medical multi-channel infusion system are all common disposable medical consumables. The above-mentioned each ordinary disposable medical consumable is the existing product that clinical daily use of hospital in the medical scene, the embodiment of the disclosure is not limited to model, manufacturer, etc. of each medical consumable, for example, divide the transfer line can use the transfer line of the model 4063005CN of Mulberry, medical check valve can use the one-way valve of SLBCV01 luer joint, liquid three-way valve in the confluence device can use the disposable medical three-way valve of the arris tablet, the syringe needle can adopt the retention needle, for example, the disposable arteriovenous retention needle of the model Supercath5 of American; when the medical multichannel infusion system disclosed by the embodiment of the disclosure is used for liquid infusion, any special medical consumable is not required, and the medical burden of liquid infusion can be reduced due to low price and wide use of common disposable medical consumable.

The set flow value to be achieved by the liquid in the infusion tube in the infusion channel can be a flow value to be achieved by the liquid in each infusion tube preset by a user according to actual demands; in practical application, the system may further include a man-machine interaction module, where the man-machine interaction module may be in communication connection with the measurement and control module in each infusion channel, so that the measurement and control module in each infusion channel obtains a set flow value input by a user through the man-machine interaction module, and for example, the user may set, through the man-machine interaction module, a set flow value that should be achieved by each of the infusion channels, where a plurality of set flow values corresponding to the plurality of infusion channels should be equal to a total infusion flow that the user expects that the liquid flow in the main infusion tube should be achieved. The embodiment of the present disclosure does not limit the manner of obtaining the set flow value.

Considering that setting the set flow values for the respective infusion channels is not convenient enough, the user may also input the target flow value to be reached by the liquid flow in the main infusion tube through the human-computer interaction module, the human-computer interaction module may share the target flow value input by the user to the measurement and control module of the respective infusion channel, based on which the measurement and control module 00 of each infusion channel is further configured to perform: acquiring a target flow value set by a user, wherein the target flow value is used for indicating a flow value to be reached by liquid flowing in a main infusion tube; and determining a set flow value to be reached by the liquid in the infusion tube according to the target flow value and the number of the infusion channels in the system, so that the liquid flow in the main infusion tube reaches the target flow value. By the mode, a user can realize accurate control of the liquid infusion flow independently according to the set flow value which is required to be achieved by the infusion channels only by setting one target flow value which is required to be achieved in the main infusion tube. The embodiment of the disclosure does not limit the implementation mode of the man-machine interaction module, so long as the required functions can be realized.

Wherein, according to the target flow value and the number of a plurality of infusion channels in the system, determining the set flow value to be reached by the liquid in the infusion tube in each infusion channel can include: dividing the target flow value Q by the number N of multiple infusion channels in the system to obtain a set flowMagnitude of the valueThat is, the average distribution of the target flow value is realized, thus, in order to ensure that the liquid flow in the main infusion tube reaches the target flow value set by the user, the set flow value corresponding to each infusion channel can be +.>Alternatively, different weight coefficients may be set for each infusion channel, and the set flow value corresponding to each infusion channel is determined according to the weight coefficient of each infusion channel, that is, weighted allocation of the target flow value is achieved, for example, assuming that the weight coefficients corresponding to the two infusion channels are 0.4 and 0.5, respectively, the set flow values corresponding to the two infusion channels may be 0.4Q and 0.5Q, respectively. It should be appreciated that embodiments of the present disclosure are not limited in the manner in which the set flow values should be determined for each infusion channel.

As described above, the extrusion force applied by the infusion bag pressurizing module to the infusion bag is positively correlated with the flow rate of the liquid in the partial infusion tube connected with the infusion bag, that is, the greater the extrusion force applied by the infusion bag pressurizing module to the infusion bag, the greater the flow rate of the liquid in the partial infusion tube connected with the infusion bag, in order to make the actual flow rate value of the liquid in the partial infusion tube connected with the infusion bag reach a preset flow rate value, the actual flow rate value of the liquid in the partial infusion tube can be collected through the detection module arranged in the infusion channel, and then the measurement and control module 00 in the infusion channel can determine the extrusion force value which needs to be applied to the infusion bag at present according to the set flow rate value and the flow rate deviation between the actual flow rate values detected at present, and then can send a control signal to the infusion bag pressurizing module based on the extrusion force value which needs to be applied to the infusion bag at present, so as to instruct the infusion bag pressurizing module to apply the extrusion force with the value to the infusion bag, thereby making the actual flow rate value of the liquid in the partial infusion tube connected with the infusion bag reach the set flow rate value. The mapping relation between the extrusion force value and the flow deviation can be constructed in advance through theoretical analysis and experimental verification, and then the extrusion force value required under different flow deviations can be determined based on the mapping relation.

The detection module in the embodiments of the present disclosure may include a flow sensor known in the art, for example, a flow sensor using ultrasonic waves as a measurement principle, so long as the detection of the flow rate of the liquid in the infusion tube can be achieved, which is not limited to the embodiments of the present disclosure. The measurement and control module in the embodiments of the present disclosure may be a Device having an operation processing control capability, for example, the measurement and control module may include one or more application specific integrated circuits (ApplicationSpecific Integrated Circuits, ASIC), a digital signal processor (Digital Signal Processing, DSP), a digital signal processing Device (DSP Device, DSPD), a Programmable logic Device (Programmable LogicDevice, PLD), a Field-Programmable gate array (Field-Programmable Gate Array, FPGA), a general purpose processor, a controller, a microcontroller, a microprocessor, other electronic units for performing functions required to be implemented by the same, or a combination thereof, which is not limited to the embodiments of the present disclosure.

Fig. 4 shows a schematic view of a medical multi-channel infusion system according to an embodiment of the present disclosure. As shown in fig. 4, the infusion bag pressurizing module 01 in each infusion channel of the medical multi-channel infusion system may include: the infusion bag pressurizer, the air pressure sensor and the air charging and discharging device are connected through an air three-way valve;

wherein, the infusion bag pressurizer is used for applying extrusion force to the infusion bag; the gas charging and discharging device is used for charging or discharging the infusion bag pressurizer so as to adjust the actual pressure of the gas in the infusion bag pressurizer, and the actual pressure of the gas in the infusion bag pressurizer is positively correlated with the extrusion force applied by the infusion bag pressurizer to the infusion bag; the air pressure sensor is used for detecting the actual air pressure value of the air in the infusion bag pressurizer.

In practical application, the infusion bag is in contact with the surface of the infusion bag pressurizer, and the infusion bag pressurizer can be a flexible common infusion bag pressurizer made of flexible materials, for example, a Clear-Cuff flexible Medical infusion bag pressurizer of Smith Medical, and the sustainable maximum gas pressure of the pressurizer is 50kPa; the infusion bag pressurizer is internally provided with an air chamber for storing air, and it is understood that the more the air filling and discharging device is used for filling air into the infusion bag pressurizer, the larger the air pressure of the air in the air chamber is, the more the infusion bag pressurizer is expanded, the larger the extrusion force applied to the infusion bag is, and then the liquid flow (namely the liquid flow rate) flowing from the infusion bag to the split infusion tube is also increased; conversely, the more the air charging and discharging device is used for discharging air from the infusion bag pressurizer, the smaller the air pressure of the air in the air chamber is, the more the infusion bag pressurizer is contracted, the smaller the extrusion force applied to the infusion bag is, and the liquid flow (namely the liquid flow rate) flowing from the infusion bag to the split infusion tube is also reduced.

In practical application, the three interfaces of the infusion bag pressurizer, the air pressure sensor, the air charging and discharging device and the air three-way valve can be connected through an air pipe, specifically, the air pressure sensor is connected with the air chamber inside the infusion bag pressurizer through the air pipe and the air three-way valve and detects the internal air pressure of the air chamber, the air chamber inside the infusion bag pressurizer is connected with the atmosphere through the air pipe, the air three-way valve and the air charging and discharging device, the air rapid charging and discharging device can achieve the rapid charging and rapid discharging functions aiming at the air chamber inside the infusion bag pressurizer, specifically, the air charging and discharging device can not only adjust the air path mode (namely adjust the air flow direction), enable the air loop to work in the charging state or the discharging state aiming at the air chamber inside the infusion bag pressurizer, but also adjust the air flow during rapid charging and discharging, namely, achieve the control of the charging and discharging speed.

Alternatively, as shown in fig. 5 (a) and 5 (b), the gas charger-discharger may include an electric gas valve and a micro gas pump; the electric air valve is used for switching the flow direction of air in the electric air valve according to the air path state indicated by the control signal so as to realize the inflation or deflation of the infusion bag pressurizer; the miniature air pump is used for adjusting the inflation speed or the deflation speed according to the air flow indicated by the control signal; the electric air valve comprises a first air valve interface a1, a second air valve interface a2, a third air valve interface a3 and a fourth air valve interface a4; the micro air pump comprises a first air pump interface b1 and a second air pump interface b2; the first air valve interface a1 is communicated with the atmosphere, the second air valve interface a2 is communicated with the first air pump interface b1, the third air valve interface a3 is communicated with the second air pump interface b2, the fourth air valve interface a3 is communicated with one interface x of the air three-way valve, and the other two interfaces z and y of the air three-way valve are respectively communicated with the air pressure sensor and the infusion bag pressurizer.

When the measurement and control module indicates the gas filling and discharging device to perform the filling, as shown in fig. 5 (a), air in the atmosphere flows from the first air valve interface a1 of the electric air valve to the second air valve interface a2, then enters the micro air pump through the first air pump interface b1 of the micro air pump through the second air valve interface a3, then the air entering the micro air pump is compressed by the micro air pump and forms compressed gas, the compressed gas is output from the second air pump interface b2 of the micro air pump, flows to the fourth air valve interface a4 through the third air valve interface a3 of the electric air valve, and enters the infusion bag pressurizer through the gas three-way valve from the fourth air valve interface a 4; and as shown in fig. 5 (b), when the measurement and control module instructs the gas filling and discharging device to perform gas discharging, compressed gas in the infusion bag pressurizer flows from the gas three-way valve to the fourth valve interface a4 of the electric valve, flows to the second valve interface a2 through the fourth valve interface a4, then enters the micro air pump from the second valve interface a2 through the first air pump interface b1 of the micro air pump, compressed gas pumped by the micro air pump is output to the third valve interface a3 of the electric valve from the second air pump interface b2 of the micro air pump, flows to the first valve interface a1 through the third valve interface a3, and enters the atmosphere from the first valve interface a 1. The extrusion force to the infusion bag can be rapidly increased by forming the inflation power through the gas inflation and deflation device, so that the effect of rapidly increasing the infusion flow is achieved, or the extrusion force to the infusion bag can be rapidly reduced by rapidly forming the air suction power, so that the effect of rapidly reducing the infusion flow is achieved.

It should be understood that those skilled in the art may use products known in the art to implement the infusion bag pressurizing module described above, and that the air tube used in the infusion bag pressurizing module may illustratively be an industrial air tube having a small caliber and capable of withstanding air pressure of at least 50kPa to form a tube, such as a PU air tube having an outer diameter of 6mm and an inner diameter of 4 mm; the gas three-way valve can be a gas three-way valve which is matched with the air pipe and can bear at least 50kPa, for example, a plastic quick-connection plug gas three-way valve for an air pipe with the outer diameter of 6mm can be adopted; the air pressure sensor can be used for being butted with an air pipe, the measuring range is more than 50kPa, and the relative accuracy is less than 1 percent, for example, a diffusion silicon air pressure sensor which is specific to an air pipe with the outer diameter of 6mm and has the measuring range of 0-60kPa and outputs a 4-20mA measuring signal can be used; wherein, the electric air valve can adopt a two-position multi-position electromagnetic valve which can be in butt joint with the air pipe and can bear at least 50kPa air pressure, such as a 45A-AC1-DDAJ-1KA model two-position four-way electromagnetic valve; the miniature air pump can adopt a miniature electric air pump which can be in butt joint with an air pipe and can bear 50kPa air pressure, such as a G4BW2460S miniature brushless adjustable speed air pump. It should be noted that the types and models adopted by the devices in the infusion bag pressurizing module are some exemplary implementation manners provided by the embodiments of the disclosure, and in fact, those skilled in the art may design the structure, the types, the models, etc. of the devices in the infusion bag pressurizing module according to actual needs, so long as the functions required to be implemented can be implemented, and the embodiments of the disclosure are not limited.

Based on the medical multi-channel infusion system illustrated in fig. 4 above, the measurement and control module 00 in each infusion channel is configured to perform: acquiring a set flow value which is needed to be reached by liquid in a separate infusion tube in an infusion channel, an actual flow value currently detected by a detection module in the infusion channel and an actual air pressure value currently detected by an air pressure sensor in the infusion channel; according to the set flow value, the current detected actual flow value and the current detected actual air pressure value, the air charging and discharging device in the infusion channel is controlled to charge or discharge the infusion bag pressurizer, so that the extrusion force applied to the infusion bag by the infusion bag pressurizer is controlled, and the actual flow value of liquid in the infusion tube connected with the infusion bag reaches the set flow value.

Wherein, above-mentioned according to setting up flow value, actual flow value and the actual atmospheric pressure value of current detection of detecting, control the gas in the infusion passageway and fill the ware and inflate or deflate infusion bag pressurizer, include: determining a set air pressure value to be reached by air in the infusion bag pressurizer according to the flow deviation between the set flow value and the current detected actual flow value; determining a current gas flow set value according to the gas pressure deviation between the set gas pressure value and the current detected actual gas pressure value, wherein the gas flow set value comprises a gas path state and a gas flow, the gas path state is used for indicating whether the gas charging and discharging device charges or discharges, and the gas flow is used for indicating the charging speed or the discharging speed of the gas charging and discharging device; and sending a control signal to the gas charging and discharging device according to the gas flow set value, wherein the control signal is used for controlling the gas charging and discharging device to charge or discharge the infusion bag pressurizer according to the gas flow set value. In this way, an accurate control of the infusion flow of the liquid can be achieved.

In order to facilitate understanding, a closed-loop control process of the liquid flow in the infusion channel is shown in fig. 6, and the flow control process is described in detail, as shown in fig. 6, a measurement and control module 00 obtains an externally input set flow value Qs, a detection module detects an actual flow value of the liquid in the infusion tube and sends the actual flow value to a signal input end 1 of the measurement and control module 00 in the form of a liquid flow measurement signal, the measurement and control module 00 reads the received liquid flow measurement signal as an actual flow value Qm, then subtracts the set flow value Qs from the actual flow value Qm to obtain a flow deviation deltaq, inputs the flow deviation deltaq into a liquid flow control algorithm, and the liquid flow control algorithm can calculate a set air pressure value Ps to be reached by the air pressure in the infusion bag pressurizer under the current flow deviation deltaq according to a mapping relation between the flow deviation and the air pressure; the method comprises the steps that an air pressure sensor detects an actual pressure value of air in an infusion bag pressurizer and sends the actual pressure value to a signal input end 2 of a measurement and control module in the form of an air pressure measurement signal, the measurement and control module reads the received air pressure measurement signal as an actual pressure value Pm, the air pressure deviation delta P is obtained by subtracting the actual pressure value Pm from a set air pressure value Ps, the air pressure deviation delta P is input into an air pressure control algorithm, the air pressure control algorithm can calculate a current air flow set value Fs according to a logical relation (such as a relation of proportion, integration or differentiation) between the air pressure deviation and air flow, and the air flow set value Fs comprises an air path state Vc and air flow Kc; then, the measurement and control module 00 respectively sends the gas path state Vc and the gas flow Kc to the electric air valve of the gas quick charging and discharging device and the micro air pump in the form of charging and discharging control signals through the signal output end 1 and the signal output end 2, so that the electric air valve switches the current gas flow direction according to the gas path state Vc indicated in the signals, and the micro air pump adjusts the gas flow when charging air or discharging air according to the gas flow Kc indicated in the signals, namely adjusts the charging speed or discharging speed, so as to determine whether the transfusion bag pressurizer needs to be charged or discharged quickly at present. Through the closed-loop control, the gas pressure of the gas chamber in the infusion bag pressurizer can be adjusted to be proper to form proper extrusion force to extrude the infusion bag, so that the actual flow value of liquid infusion in the infusion dividing pipe is the same as the set flow value set by a user, and the accurate and rapid control of the liquid flow in the infusion process is realized.

The above process can be understood as that the user sets a set flow value to be reached by the flow of the liquid in the infusion tube, the detection module 02 measures the actual flow of the liquid during infusion to the measurement and control module 00, the measurement and control module 00 calculates a set air pressure value to be reached by the air pressure in the infusion bag pressurizer according to the set flow value of the liquid and the actual flow value of the liquid, the air pressure sensor measures the actual air pressure value of the air chamber in the infusion bag pressurizer and sends the actual air pressure value to the measurement and control module 00, the measurement and control module 00 calculates the air flow set value according to the set air pressure value and the actual air pressure value and sends the air flow set value to the air charging and discharging device in the form of a charging and discharging control signal, the air charging and discharging device adjusts the state and speed of charging and discharging according to the signal indication, the actual air pressure in the infusion bag pressurizer is adjusted to be the same as the set air pressure value under the above effect, and the infusion flow of the liquid in the infusion tube connected with the infusion bag is adjusted to be the same as the set air pressure value under the action of the extrusion force exerted by the infusion bag pressurizer on the infusion bag.

As described above, in the prior art, since the operation is a single channel operation, it is generally necessary to stop the whole infusion operation and then manually discharge the liquid in the infusion tube and resume the operation, and based on this, the embodiment of the disclosure provides a medical multi-channel infusion system as shown in fig. 7, which can automatically discharge the air bubbles in the liquid without affecting the infusion operation of other infusion channels when the air bubbles appear in the liquid in the infusion tube disposed in the infusion channel.

As shown in fig. 7, the infusion tube is provided with an exhaust chamber, and the exhaust chamber can be an exhaust chamber of the infusion tube or an assembled exhaust chamber, which is not limited in the embodiments of the disclosure; also included in each infusion channel is: a flow stop device 03, wherein the flow stop device 03 is used for blocking or conducting the flow of liquid in the infusion tube; the flow stop device may be a non-contact flow stop device, as shown in fig. 8 (a), when the flow stop device in the on state does not apply a pressing force to the outer wall of the split infusion tube, the liquid in the split infusion tube normally flows, as shown in fig. 8 (b), and the flow stop device in the blocking state deforms the split infusion tube by applying a pressing force to the outer wall of the split infusion tube to block the liquid flow, that is, the flow stop device can force the infusion tube to deform and rapidly pinch off the infusion liquid flow therein, so that the infusion tube stops infusing.

Optionally, the embodiment of the present disclosure further provides a structure of a flow stopper as shown in fig. 9 (a) and 9 (b), where, as shown in fig. 9 (a) and 9 (b), the flow stopper includes a clamp for fixing a sub-infusion tube, and an extrusion assembly for blocking or conducting a flow of a liquid in the sub-infusion tube fixed by the clamp, and the extrusion assembly includes a motor, a cam connected to the motor through a rotation shaft, and a ball disposed at a top end of the cam, and the motor communicates with the measurement and control module 00 through a signal line to receive a control signal sent by the measurement and control module 00; as shown in fig. 9 (a), no force acts between the extrusion assembly and the outer wall of the sub-infusion tube in the on state, so that the sub-infusion tube is not deformed, and the liquid in the sub-infusion tube normally circulates; as shown in fig. 9 (b), the force is applied between the pressing member and the outer wall of the sub-tube in the blocked state, so that the sub-tube is deformed, and the liquid in the sub-tube is blocked from flowing.

Based on the flow stop device shown in fig. 9 (a) and 9 (b), when the extrusion assembly is required to enter a blocking state from a conducting state, a motor in the extrusion assembly generates torque and drives the cam to rotate through the rotating shaft, so that the balls at the top end of the cam apply pressure to the outer wall of the split infusion tube to block the circulation of liquid in the split infusion tube; when the extrusion assembly is required to return to the conducting state from the blocking state, the motor in the extrusion assembly generates reverse torque and drives the cam to reversely rotate through the rotating shaft, so that the balls at the top end of the cam release the pressure applied to the outer wall of the split infusion tube, and the circulation of liquid in the split infusion tube is conducted.

It should be understood that the flow stop shown in fig. 9 (a) and 9 (b) is one possible implementation manner provided by the embodiments of the present disclosure, and in fact, those skilled in the art may design the hardware structure of the flow stop according to actual needs, so long as the flow of the liquid in the infusion tube can be blocked or conducted in a non-contact manner, which is not limited to the embodiments of the present disclosure.

Based on the system shown in fig. 7, the detection module 02 in each infusion channel is further configured to detect whether bubbles exist in the liquid in the infusion tube and send the bubble detection result to the measurement and control module 00 in the infusion channel;

The measurement and control module 00 in each infusion channel is further configured to perform: under the condition that the bubble detection result sent by the detection module 02 in the infusion channel represents that bubbles exist in the liquid in the infusion tube, controlling the flow stopper 03 in the infusion channel to block the flow of the liquid in the infusion tube so as to enable the gas in the liquid in the infusion tube to move to and be discharged from the discharge chamber; and controlling the flow stop device 03 in the infusion channel to conduct the circulation of the liquid in the infusion tube under the condition that the bubble detection result sent by the detection module 02 in the infusion channel indicates that no bubble exists in the liquid in the infusion tube.

The detection module may use a multifunctional sensor known in the art, so that the detection module can detect both flow and bubbles, specifically, may use a multifunctional sensor for flow measurement and bubble detection based on an ultrasonic wave as a measurement principle, for example, may use an FD-XS1 sensor of kenji, which is not limited to the embodiments of the present disclosure.

For easy understanding, explaining in detail the process of handling the abnormal air bubble in the infusion channel shown in fig. 10, as shown in fig. 10, the detection module 02 detects whether an air bubble exists in the liquid in the infusion tube, the air bubble detection result is sent to the signal input end of the measurement and control module 00 in the form of an air bubble detection measurement signal, the measurement and control module 00 reads the received air bubble detection measurement signal as an air bubble detection result Bm, when the air bubble detection result Bm indicates that the air bubble is detected (i.e. the air bubble exists in the liquid in the infusion tube), the measurement and control module 00 sends a blocking control signal Scf to the flow stopper through the signal output end, the blocking control signal Scf indicates that the flow stopper 03 is switched to a conducting state, and when the air bubble detection result Bm indicates that the air bubble is not detected (i.e. the air bubble does not exist in the liquid in the infusion tube), the measurement and control module 00 outputs a conducting control signal Sco to the flow stopper 03 through the signal output end, and the conducting control signal Sco controls the flow stopper to be switched to the conducting state; the on-off switching control signal includes a conducting control signal Sco or a blocking control signal Scf, and the current stopper 03 is instructed to switch to a conducting state or a blocking state according to the control signal Sco or Scf. For example, taking the case that a bubble is detected, that is, in the case that the bubble detection result indicates that a bubble exists in the infused liquid, the measurement and control module 00 executes according to the flow path of the solid arrow in fig. 10, sends the blocking control signal Scf to the flow stopper 03 through the signal output end, and the flow stopper 03 can quickly block the flow of the liquid in the infusion tube under the action of the blocking control signal Scf, for example, can block the flow of the liquid in the infusion tube in the manner of fig. 9 (b). It should be understood that when the liquid in the branch infusion tube is stationary due to blocking of circulation, because the buoyancy force of the bubbles in the liquid is greater than the gravity force, the bubbles flow into the exhaust chamber in the branch infusion tube according to the track shown by the arrow in the figure, then float out of the liquid in the exhaust chamber, and finally enter air; after the air bubbles are completely discharged from the liquid, that is, when no air bubbles exist in the liquid, the measurement and control module 00 can send a conduction control signal Sco to the flow stop device 03 to control the flow of the liquid in the infusion tube, for example, the flow of the liquid in the infusion tube is rapidly conducted in a manner shown in fig. 9 (a), so that the infusion tube in the infusion channel is restored to the normal infusion state.

By the method, when abnormal conditions such as bubbles occur in part of the infusion channels in the infusion channels, the state of constant total infusion flow can still be maintained to continue to work, abnormal information can be shared among all the infusion channels in real time, when the part of the infusion channels are abnormal and stop working, the part of the abnormal infusion channels can execute a bubble abnormal processing function by taking bubble abnormality as an example, the bubble abnormal processing function in the abnormal infusion channels can be realized through closed-loop control of bubbles, specifically, when the detection module detects that bubbles occur in the infusion tube, the state of bubble detection signals sent to the measurement and control module (namely, the bubble detection result is changed), the state of the bubble detection signals sent by the sensor module is changed into the state of blocking control signals sent to the flow stopper, the bubbles in the infusion tube are quickly blocked for infusion under the action of the blocking control signals, the bubbles float out of the liquid surface and enter the air in the air chamber from bottom to top under the action of the buoyancy and gravity of the infusion tube, and the rest of the residual infusion channels which normally work can increase the infusion flow of the infusion tube, so that the total infusion flow in the infusion tube is kept unchanged.

As described above, when a bubble appears in the liquid in the infusion tube of a certain infusion channel, the infusion tube of the infusion channel will be blocked from flowing, that is, the infusion channel will stop the infusion operation, and a part of the infusion channels may malfunction and stop the operation during the use of the system, so that the infusion channels which stop the operation due to the occurrence of the bubble or the malfunction can be referred to as abnormal infusion channels; because the target flow value set by the user is the sum of the set flow values corresponding to the infusion channels, in order to enable the actual flow of the liquid in the main infusion tube to still keep the target flow value under the condition that partial abnormal infusion channels stop working in the infusion channels, in one possible implementation manner, the measurement and control module 00 in the abnormal infusion channels is also used for sending abnormal information to the rest infusion channels still working normally in the system; the abnormality information may indicate that the infusion channel that sent the abnormality information has stopped working;

based on this, the measurement and control module in the remaining infusion channels is further configured to perform: under the condition that abnormal information sent by an abnormal infusion channel is received, determining a new set flow value which is needed to be reached by liquid in a split infusion tube in the residual infusion channel according to a target flow value and the quantity of the residual infusion channels, so that the liquid flow in a main infusion tube keeps the target flow value;

According to the newly set flow value, the actual flow value currently detected by the detection module in the residual infusion channel and the actual air pressure value of the air in the infusion bag pressurizer currently detected by the air sensor in the infusion bag pressurizing module, the air charging and discharging device in the infusion bag pressurizing module is controlled to charge or discharge the infusion bag pressurizer, so that the extrusion force applied by the infusion bag pressurizer to the infusion bag is controlled to enable the actual flow value of the liquid in the infusion tube connected with the infusion bag to reach the newly set flow value.

It will be appreciated that when a portion of the infusion channels of the system cease to operate, the remaining infusion channels that are still operating properly need to have their own infusion flow rate increased appropriately to maintain the total flow rate of the main infusion line at the target flow rate value. Assuming that N infusion channels all work normally, the set flow value of each infusion channel is Q _s ＝ ^Q _N The liquid flow in the main infusion tube is that the sum of the liquid flow in the N sub-infusion tubes is equal to a target flow value Q; if the infusion channel 1 and the infusion channel 3 stop working, the infusion channel 1 and the infusion channel3, respectively transmitting abnormal information to the residual infusion channels (namely the infusion channel 2, the infusion channel 4 to the infusion channel N) still working normally by the measurement and control module in each residual infusion channel, and after receiving the abnormal information, respectively determining a new set flow value to be reached by the liquid in the infusion tube in the residual infusion channel according to the target flow value Q and the number N-a of the residual infusion channels (namely N-2), wherein a is the number of the abnormal infusion channels due to abnormal stopping operation Namely->This corresponds to an increase in the set flow values of infusion channel 2, infusion channel 4 to infusion channel N>The measurement and control module of the remaining infusion channels can refer to the closed-loop control process of the liquid flow in the single infusion channel shown in fig. 6, so as to control the gas charging and discharging device in the infusion bag pressurizing module to charge or discharge the infusion bag pressurizer according to the newly set flow value, the actual flow value currently detected by the detecting module in the remaining infusion channel and the actual pressure value currently detected by the gas sensor in the infusion bag pressurizing module, namely, the actual flow value of the liquid flow in the separate infusion tube is controlled to approach the newly set flow value, and the liquid flow in the main infusion tube is kept to be #> I.e. equal to the target flow value when the infusion channels are all working properly. By the mode, the infusion channels can share abnormal information and can rapidly call the remaining infusion channels which still work normally to make up for flow loss, so that the liquid flow in the main infusion tube still keeps the target flow value set by a user, and the infusion device has the advantages thatHas higher fault tolerance.

It should be noted that, the infusion channels in the medical multi-channel infusion system according to the embodiments of the present disclosure are independent from each other, so that the system is not dependent on a certain module as a host for control. The man-machine interaction module is mainly responsible for providing a target flow value which is input by a user and is reached by the liquid flow in the main infusion tube; the information such as the target flow value, the set flow value and the abnormal information can be shared in the communication network of the system in real time, namely, the information sharing exists among the infusion channels of the system. And the flow distribution mode corresponding to each infusion channel can be average distribution or weighted distribution, namely, each infusion channel does not depend on a host computer to determine the infusion flow to be realized, and the coordination results can be average distribution, weighted distribution and the like by mutual coordination among the infusion channels.

In one possible implementation, the measurement and control module in the embodiments of the present disclosure is implemented using various centralized or distributed integration schemes. Fig. 11 is a schematic structural diagram of a cloud and fog architecture formed by a multiple-input multiple-output closed-loop measurement and control module (which is an embodiment of the measurement and control module 00) and a man-machine interaction module 11 according to an embodiment of the present disclosure. As shown in fig. 11, the cloud network includes a man-machine interaction module 11, in which an IPT23486 node is located in the man-machine interaction module 11, and the man-machine interaction module can convert the main infusion tube flow determined by an operator into a target flow value through a man-machine interaction function. One cloud network can automatically interact information with a plurality of fog networks. The IPT22101 nodes are used for realizing information automatic interaction between the cloud network and the fog network, each IPT22101 has double identities, belongs to the cloud network and each fog network, and specifically, one IPT22101 node can realize the information automatic interaction function of the IPT23486 in the man-machine interaction module 11 and any module node in the corresponding measurement and control module 00, and can also realize the information automatic interaction function with other IPT22101 nodes. The measurement and control module 00 can comprise 4 module nodes of IPT22420, IPT22482, IPT22161, IPT22165 and the like; the IPT22420 node is configured to convert the 4-20mA signals (i.e., the gas pressure measurement signal and the liquid flow measurement signal) respectively output by the gas pressure sensor and the detection module (i.e., the non-contact bubble flow sensor) into an actual gas pressure value Pm and an actual flow value Qm. The IPT22482 node is configured to convert a switching value signal (i.e., a bubble detection measurement signal) output by a detection module (i.e., a non-contact bubble flow sensor) into a bubble detection result Bm. The IPT22161 node is used to output a PWM signal to the micro air pump that characterizes the flow of air, which can control the power of the micro air pump when it is inflated or deflated, i.e. the inflation speed or deflation speed. The IPT22165 node is used for outputting corresponding switching value signals to the electric air valve and the flow stopper, wherein the switching value signals output to the electric air valve represent the state of an air path so as to control the switching of the rapid inflation and the rapid deflation of the infusion bag pressurizer, and the switching value signals output to the flow stopper comprise a blocking control signal or a conducting control signal so as to control the switching of the conducting state and the blocking state of the flow stopper. The automatic interaction of key information can be realized among the module nodes, for example, the IPT22420 node can automatically interact with other module nodes to obtain an actual air pressure value Pm and an actual flow value Qm, and the IPT22482 node can automatically interact with other module nodes to obtain a bubble detection result Bm; the closed-loop control algorithm used in the system (for example, the related algorithm used in implementing the closed-loop control process in fig. 6 and the bubble anomaly control process in fig. 10) may be integrated in any module node, for example, the closed-loop control algorithm may be integrated in an IPT22161 node, the human-computer interaction module 11 may obtain a target flow value input by a user, the IPT12101 node further sends the target flow value to the fog network of each channel, each channel coordinates with each other based on the target flow value and determines its own set flow value Qs, and then the set flow value Qs may be sent to its own IPT22161 node, so that the closed-loop control algorithm in the IPT22161 node may implement the closed-loop control process in fig. 6 according to the set flow value Qs, the actual flow value Qm and the actual air pressure value Pm, thereby implementing accurate and rapid control of the infusion flow.

The medical multi-channel infusion system provided by the embodiment of the disclosure can perform infusion by adopting a mutually independent multi-infusion-channel parallel infusion mode, can realize any number of channel expansion as required, and has the same and independent internal structure and principle of each infusion channel. Each infusion channel comprises an infusion loop, a gas loop and a measurement and control module, wherein high-pressure gas can be stored in an infusion bag pressurizer in the gas loop, and a certain force is generated on the outside of a common infusion bag to form power for quick infusion; the air pressure sensor of the air loop is connected with the transfusion bag pressurizer of the transfusion loop through an air pipe, and various sensors and actuators of the transfusion loop and the air loop are connected with the input and output ports of the measurement and control module through measurement and control signal lines. In the infusion loop, the infusion liquid in each infusion channel comes from a common infusion bag, is output through a common disposable medical infusion tube, is provided with an exhaust chamber, passes through a detection module, and then passes through a medical non-contact flow stopper, and the tail end of the infusion tube is connected with a medical one-way valve so as to prevent liquid from flowing back. The output end of the medical one-way valve is connected to a main infusion tube through a confluence device constructed by common medical consumables, and the tail end of the main infusion tube is connected with an injection needle to form a multichannel parallel rapid and accurate infusion loop. The main function of the confluence device is to collect the liquid from different infusion tubes to the main infusion tube for infusion, and the confluence device can be realized through a common liquid three-way valve. It follows that no special medical consumables need to be used in the whole infusion circuit. In the gas loop, the power for realizing quick and accurate injection of a common infusion bag is also derived from an infusion bag pressurizer, an inner air chamber of the infusion bag pressurizer is communicated with an air pressure sensor and a gas charging and discharging device, the gas charging and discharging device can establish a charging and discharging passage between the infusion bag pressurizer and the atmosphere, and under the action of a measurement and control module, the functions of quick and accurate charging and quick discharging can be realized so as to realize quick and accurate infusion of each infusion channel.

According to the medical multi-channel infusion system disclosed by the embodiment, the design is carried out based on common disposable medical consumables, the multi-channel parallel injection mode constructed by a plurality of independent infusion channels is adopted for infusion, the tail end of an infusion tube in each infusion channel is connected with a medical one-way valve, all the branch infusion tubes at the tail ends of the medical one-way valves are connected to a main infusion tube in parallel through a confluence device, and as each independent infusion channel is provided with air pressure and flow closed-loop control, the flow requirement required by rapid injection can be met, the accurate control requirement of infusion flow and capacity can be met, meanwhile, the infusion can be realized through multi-channel time-sharing operation, and abnormal conditions such as bubbles are treated. Because the whole system hardly uses any special disposable medical consumable, the medical burden of the user can be greatly reduced.

The flowcharts and block diagrams in the figures illustrate the architecture, functionality, and operation of possible implementations of systems according to various embodiments of the present disclosure. In this regard, a block in the flowchart or block diagrams may represent a module, segment, or node, which comprises one or more executable instructions for implementing the specified logical function(s). In some alternative implementations, the functions noted in the block may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved. It will also be noted that each block of the block diagrams and/or flowchart illustration, and combinations of blocks in the block diagrams and/or flowchart illustration, can be implemented by special purpose hardware-based systems which perform the specified functions or acts, or combinations of special purpose hardware and computer instructions.

The foregoing description of the embodiments of the present disclosure has been presented for purposes of illustration and description, and is not intended to be exhaustive or limited to the embodiments disclosed. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the various embodiments described. The terminology used herein was chosen in order to best explain the principles of the embodiments, the practical application, or the technical improvements in the marketplace, or to enable others of ordinary skill in the art to understand the embodiments disclosed herein.

Claims

1. A medical multi-channel infusion system, the system comprising: a plurality of infusion channels; the disposable infusion consumable comprises infusion bags and a plurality of sub-infusion pipes connected with the infusion bags, wherein liquid flowing in the sub-infusion pipes of the infusion channels is converged into a main infusion pipe through a confluence device, and the tail end of the main infusion pipe is connected with an injection needle;

wherein each infusion channel comprises: the infusion bag pressurizing module, the detecting module and the measuring and controlling module; the infusion bag pressurizing modules in each infusion channel are used for applying extrusion force to the infusion bags arranged in the infusion channels, and the extrusion force applied by the infusion bag pressurizing modules to the infusion bags is positively correlated with the flow of liquid in the infusion dividing pipes connected with the infusion bags; the detection module in each infusion channel is used for detecting the actual flow value of the flowing liquid in the infusion tube of each infusion channel;

The measurement and control module in each infusion channel is configured to perform: acquiring a set flow value which is needed to be reached by liquid in a separate infusion tube in an infusion channel, and acquiring an actual flow value currently detected by a detection module in the infusion channel; and controlling extrusion force applied to the infusion bag by the infusion bag pressurization module in the infusion channel according to the set flow value and the current detected actual flow value, so that the actual flow value of liquid in the infusion tube connected with the infusion bag reaches the set flow value.

2. The system of claim 1, wherein the infusion bag pressurization module comprises: the infusion bag pressurizer, the air pressure sensor and the air charging and discharging device are connected through an air three-way valve;

wherein the infusion bag pressurizer is used for applying extrusion force to the infusion bag; the gas charging and discharging device is used for charging or discharging the infusion bag pressurizer so as to adjust the actual pressure of the gas in the infusion bag pressurizer, and the actual pressure of the gas in the infusion bag pressurizer is positively correlated with the extrusion force applied by the infusion bag pressurizer to the infusion bag; the air pressure sensor is used for detecting the actual air pressure value of the air in the infusion bag pressurizer;

Wherein the measurement and control module in each infusion channel is configured to perform: acquiring a set flow value which is needed to be reached by liquid in a separate infusion tube in an infusion channel, an actual flow value currently detected by a detection module in the infusion channel and an actual air pressure value currently detected by an air pressure sensor in the infusion channel; and controlling the gas charging and discharging device in the infusion channel to charge or discharge the infusion bag pressurizer according to the set flow value, the current detected actual flow value and the current detected actual air pressure value so as to control the extrusion force applied by the infusion bag pressurizer to the infusion bag and enable the actual flow value of liquid in the infusion tube connected with the infusion bag to reach the set flow value.

3. The system of claim 2, wherein the controlling the gas filling and discharging device in the infusion channel to fill or discharge the infusion bag pressurizer according to the set flow value, the current detected actual flow value and the current detected actual air pressure value comprises:

determining a set air pressure value to be reached by air in the infusion bag pressurizer according to the flow deviation between the set flow value and the current detected actual flow value;

determining a current gas flow set value according to the gas pressure deviation between the set gas pressure value and the current detected actual gas pressure value, wherein the gas flow set value comprises a gas path state and a gas flow, the gas path state is used for indicating whether the gas charging and discharging device charges or discharges, and the gas flow is used for indicating the charging speed or the discharging speed of the gas charging and discharging device;

And sending a control signal to the gas charging and discharging device according to the gas flow set value, wherein the control signal is used for controlling the gas charging and discharging device to charge or discharge the infusion bag pressurizer according to the gas flow set value.

4. The system of claim 3, wherein the infusion bag pressurizer is made of flexible materials, and the gas filling and discharging device comprises an electric air valve and a miniature air pump; the electric air valve is used for switching the flow direction of air in the electric air valve according to the air path state indicated by the control signal so as to realize inflation or deflation of the infusion bag pressurizer; the miniature air pump is used for adjusting the inflation speed or the deflation speed according to the air flow indicated by the control signal;

the electric air valve comprises a first air valve interface, a second air valve interface, a third air valve interface and a fourth air valve interface; the miniature air pump comprises a first air pump interface and a second air pump interface; the first air valve interface is communicated with the atmosphere, the second air valve interface is communicated with the first air pump interface, the third air valve interface is communicated with the second air pump interface, the fourth air valve interface is communicated with one interface of the air three-way valve, and the other two interfaces of the air three-way valve are respectively communicated with the infusion bag pressurizer and the air pressure sensor;

When the gas charging and discharging device performs charging, air in the atmosphere flows to a second air valve interface from a first air valve interface of the electric air valve, then enters the micro air pump from the second air valve interface through a first air pump interface of the micro air pump, then the micro air pump compresses the entering air and forms compressed gas, the compressed gas is output from the second air pump interface of the micro air pump, flows to a fourth air valve interface through a third air valve interface of the electric air valve, and enters the transfusion bag pressurizer from the fourth air valve interface through a gas three-way valve;

when the air charging and discharging device executes air discharging, compressed air in the infusion bag pressurizer flows to a fourth air valve interface of the electric air valve from the air three-way valve, flows to a second air valve interface through the fourth air valve interface, then enters the micro air pump from the second air valve interface through a first air pump interface of the micro air pump, compressed air pumped by the micro air pump is output to a third air valve interface of the electric air valve from the second air pump interface of the micro air pump, flows to the first air valve interface through the third air valve interface and enters the atmosphere from the first air valve interface.

5. The system of claim 1, wherein the detection module in each infusion channel is further configured to detect the presence of air bubbles in the fluid in the infusion line and send the air bubble detection results to the measurement and control module in the infusion channel; an exhaust chamber is arranged on the branch infusion tube;

Also included in each infusion channel is: the flow stop device is used for blocking or conducting the circulation of liquid in the infusion tube; the flow stopper deforms the split infusion tube by applying pressure to the outer wall of the split infusion tube to block liquid circulation, and when the pressure is not applied to the outer wall of the split infusion tube, the liquid in the split infusion tube normally circulates;

the measurement and control module in each infusion channel is further configured to perform: under the condition that the bubble detection result sent by the detection module in the infusion channel represents that bubbles exist in the liquid in the infusion tube, controlling the flow stopper in the infusion channel to block the circulation of the liquid in the infusion tube so as to enable the gas in the liquid in the infusion tube to move to and be discharged from the discharge chamber; the method comprises the steps of,

under the condition that the bubble detection result sent by the detection module in the infusion channel represents that no bubble exists in the liquid in the infusion tube, the flow stopper in the infusion channel is controlled to conduct the circulation of the liquid in the infusion tube.

6. The system of claim 5, wherein the stopper comprises a clamp for securing a portion of the tube and a squeeze assembly for blocking or communicating fluid flow within the portion of the tube secured by the clamp; the extrusion assembly in the conducting state has no force with the outer wall of the sub-infusion tube, so that the sub-infusion tube does not deform, and liquid in the sub-infusion tube normally circulates; the extrusion component in the blocking state has a force with the outer wall of the branch infusion tube, so that the branch infusion tube is deformed, and the liquid in the branch infusion tube is blocked for circulation.

7. The system of any one of claims 1 to 6, wherein the measurement and control module of each infusion channel is further configured to perform: acquiring a target flow value set by a user, wherein the target flow value is used for indicating a flow value to be reached by liquid flowing in the main infusion tube; and determining a set flow value to be reached by the liquid in the infusion tube of each infusion channel according to the target flow value and the number of the infusion channels in the system, so that the liquid flow in the main infusion tube reaches the target flow value.

8. The system of claim 7, wherein in the event that a portion of the plurality of infusion channels cease to function, the measurement and control module in the abnormal infusion channel is further configured to send abnormality information to the remaining infusion channels of the system that are still functioning properly;

the measurement and control module in the remaining infusion channels is further configured to perform:

under the condition that abnormal information sent by an abnormal infusion channel is received, determining a new set flow value which is needed to be reached by liquid in a split infusion tube in the residual infusion channel according to the target flow value and the quantity of the residual infusion channels, so that the liquid flow in the main infusion tube keeps the target flow value;

And controlling the gas charging and discharging device in the infusion bag pressurizing module to charge or discharge the infusion bag pressurizer according to the new set flow value, the actual flow value currently detected by the detecting module in the residual infusion channel and the actual pressure value of the gas in the infusion bag pressurizer currently detected by the gas sensor in the infusion bag pressurizing module so as to control the extrusion force applied by the infusion bag pressurizer to the infusion bag to enable the actual flow value of the liquid in the infusion tube connected with the infusion bag to reach the new set flow value.

9. The system of claim 1, wherein the manifold comprises N-1 three-way liquid valves, an output of a designated one of the N-1 three-way liquid valves being connected to the main infusion line; the N-1 liquid three-way valves are used for connecting N sub-infusion tubes corresponding to the N infusion channels in parallel so as to collect the liquid circulating in the N sub-infusion tubes into the main infusion tube, wherein N is a positive integer.

10. The system of claim 9, wherein the distal end of each split infusion tube is connected to a liquid three-way valve in the manifold via a medical check valve for preventing backflow of liquid;

The infusion bag, the branch infusion tube, the main infusion tube, the injection needle, the medical one-way valve and the confluence device are all common disposable medical consumables.