CN116808168A - Traditional Chinese medicine for treating acute exacerbation stage of chronic obstructive pulmonary disease - Google Patents
Traditional Chinese medicine for treating acute exacerbation stage of chronic obstructive pulmonary disease Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for treating acute exacerbation of slow-retention lung, which can effectively solve the problem of medication for treating acute exacerbation of slow-retention lung, and comprises the following components in parts by weight: 90-110g of ephedra, 80-100g of cassia twig, 108-132g of rhizoma pinellinae praeparata, 109-132g of snakegourd fruit, 90-110g of allium macrostemon, 109-132g of white peony root, 80-100g of dried ginger, 90-110g of perilla fruit, 135-165g of red-rooted salvia root, 27-33g of asarum, 54-66g of schisandra chinensis and 54-66g of honey-fried licorice root, and the Chinese medicinal preparation has the advantages of rich raw materials, scientific and reasonable monarch, minister, assistant and guide compatibility, simple preparation method, easy production and convenient administration, has the effects of warming lung, dispelling cold, dispersing lung qi, activating blood circulation, resolving phlegm, removing blood stasis and the like, and can be used for patients with acute exacerbation stage of chronic lung obstruction, external cold and internal drinking symptoms of cough, asthma and dyspnea with difficulty in lying down, and thin phlegm; dark complexion, pain and aversion to cold; the Chinese medicinal composition has the advantages of stable and reliable curative effect, no toxic or side effect during the administration, and practical clinical application value, and can be used for treating other patients with external cold and internal drinking type pulmonary diseases such as chronic pneumonia, chronic bronchitis and the like.
Description
Technical Field
The invention relates to a medicine, in particular to a traditional Chinese medicine for treating acute exacerbation of chronic obstructive pulmonary disease.
Background
At present, along with the stimulation of harmful factors such as smoking, infection, atmospheric pollution and the like, the morbidity of a respiratory system is continuously increased, and the healthy life of human beings is seriously endangered. The chronic obstructive pulmonary disease is a common disease and frequently-occurring disease of the respiratory system, and western medicine usually adopts medicines such as glucocorticoid, bronchodilator or antibiotics to carry out symptomatic treatment, but has poor long-term curative effect, easily repeated disease conditions, drug resistance, adverse reaction and the like although the symptoms can be relieved to a certain extent. The traditional Chinese medicine is based on the whole, and the symptoms are combined based on syndrome differentiation, so that the symptoms of patients can be effectively relieved, the times of attacks can be reduced, and no toxic or side effect is caused.
The traditional medicine mostly belongs to the category of lung distension and slow-resistance, and from the theory of traditional Chinese medicine, the lung governs qi, which is the highest in the lung, is the Hua Gao of the five zang organs. The lung is the most vulnerable to exogenous pathogenic factors and internal injury because it opens into the nose, merges with the fur and the exterior of the main body, and is a delicate organ, which is not resistant to pathogenic factors, and the invasion of the pathogenic factors causes the lung qi to be unclear and to be descending, which leads to the adverse dispersing and descending of the lung qi, the upward adverse flow of the forced qi to cause cough, and the abnormal ascending and descending of the lung qi to be asthma. Chronic cough and asthma repeatedly occur, and the deficiency of the lung, spleen and kidney is not healed, and the deficiency of the lung, spleen and kidney can not distribute body fluid, spleen deficiency can not be transfused, kidney deficiency can not be steamed, phlegm turbidity and blood stasis can be gradually formed, the airway is blocked, if the internal fluid is stopped, and wind-cold is caused again, the syndrome of external cold and internal fluid can be caused. The chronic obstructive pulmonary disease is mainly caused by chronic disease lung deficiency and phlegm stasis retention, and the attack of the chronic obstructive pulmonary disease is aggravated by exogenous evil caused by the chronic disease lung deficiency, and the traditional Chinese medicine for treating the chronic obstructive pulmonary disease has unsatisfactory curative effect due to the problems of component compatibility, so that the development of a new medicine for treating the chronic obstructive pulmonary disease is a serious technical problem.
Disclosure of Invention
Aiming at the situation, the invention aims to overcome the defects of the prior art and provide the traditional Chinese medicine for treating the acute exacerbation stage of the chronic obstructive pulmonary disease, which can effectively solve the problem of the treatment medication of the acute exacerbation stage of the chronic obstructive pulmonary disease.
The technical scheme of the invention is that a traditional Chinese medicine for treating acute exacerbation of chronic obstructive pulmonary disease is prepared from the following components in parts by weight: 90-110g of ephedra, 80-100g of cassia twig, 108-132g of rhizoma pinellinae praeparata, 109-132g of snakegourd fruit, 90-110g of allium macrostemon, 109-132g of white paeony root, 80-100g of dried ginger, 90-110g of perilla fruit, 135-165g of red-rooted salvia root, 27-33g of asarum, 54-66g of Chinese magnoliavine fruit and 54-66g of honey-fried licorice root, wherein the twelve medicinal materials are decocted for 1 hour by adding water with the volume of 10 times of weight for the first time, filtered and the filtrate is collected for standby; decocting the residues in 8 times of water for 1 hr, wherein the weight and volume are calculated as g solid and mL liquid (hereinafter, the same shall apply), filtering, mixing the filtrates, concentrating the filtrate to relative density not lower than 1.02, filtering, packaging, and sterilizing.
The invention has the advantages of rich raw materials, scientific and reasonable compatibility of monarch, minister, assistant and guide, simple preparation method, easy production and convenient administration, has the effects of warming lung, dispelling cold, dispersing lung qi, activating blood circulation, resolving phlegm, removing blood stasis and the like, and can be used for treating the external cold and internal drink symptoms of patients with acute exacerbation of chronic obstructive pulmonary disease, wherein symptoms are that cough and gasp are difficult to recur, and phlegm is colored white; dark complexion, pain and aversion to cold; the Chinese medicinal composition has the advantages of stable and reliable curative effect, no toxic or side effect during the administration, and practical clinical application value, and can be used for treating other patients with external cold and internal drinking type pulmonary diseases such as chronic pneumonia, chronic bronchitis and the like.
Description of the embodiments
The following describes specific embodiments of the present invention in detail with reference to examples.
The invention may be embodied by the following examples.
Example 1
The invention relates to a traditional Chinese medicine for treating acute exacerbation of chronic obstructive pulmonary disease, which comprises the following components in parts by weight: 100g of ephedra, 90g of cassia twig, 120g of rhizoma pinellinae praeparata, 120g of snakegourd fruit, 100g of allium macrostemon, 120g of white paeony root, 90g of dried ginger, 100g of perilla seed, 150g of red sage root, 30g of asarum, 60g of shizandra berry and 60g of honey-fried licorice root, wherein the twelve medicinal materials are decocted for 1 hour by adding 10 times of water by weight volume for the first time, filtered and the filtrate is collected for standby; decocting the residues with 8 times of water for 1 hr, filtering, mixing the filtrates, concentrating the filtrate to relative density of not less than 1.02, filtering, packaging, and sterilizing.
Example 2
The invention relates to a traditional Chinese medicine for treating acute exacerbation of chronic obstructive pulmonary disease, which comprises the following components in parts by weight: 93g of ephedra, 82g of cassia twig, 110g of rhizoma pinellinae praeparata, 129g of snakegourd fruit, 92g of allium macrostemon, 114g of white paeony root, 87g of dried ginger, 93g of perilla seed, 161g of red sage root, 32g of asarum, 57g of shizandra berry and 56g of honey-fried licorice root.
Example 3
The invention relates to a traditional Chinese medicine for treating acute exacerbation of chronic obstructive pulmonary disease, which comprises the following components in parts by weight: 107g of ephedra, 98g of cassia twig, 130g of rhizoma pinellinae praeparata, 112g of snakegourd fruit, 108g of allium macrostemon, 127g of white peony root, 103g of dried ginger, 107g of perilla seed, 139g of red sage root, 28g of asarum, 63g of schisandra chinensis and 64g of honey-fried licorice root, and the preparation method is the same as that of example 1.
Example 4
The invention relates to a traditional Chinese medicine for treating acute exacerbation of chronic obstructive pulmonary disease, which comprises the following components in parts by weight: 92g of ephedra, 87g of cassia twig, 131g of rhizoma pinellinae praeparata, 111g of snakegourd fruit, 91g of allium macrostemon, 112g of white paeony root, 82g of dried ginger, 92g of perilla seed, 137g of red sage root, 28g of asarum, 55g of shizandra berry and 58g of honey-fried licorice root.
Example 5
The invention relates to a traditional Chinese medicine for treating acute exacerbation of chronic obstructive pulmonary disease, which comprises the following components in parts by weight: 108g of ephedra, 93g of cassia twig, 109g of rhizoma pinellinae praeparata, 129g of snakegourd fruit, 109g of allium macrostemon, 129g of white peony root, 108g of dried ginger, 108g of perilla seed, 163g of red sage root, 32g of asarum, 65g of schisandra fruit and 62g of honey-fried licorice root, and the preparation method is the same as that of example 1.
In the above medicament, wherein:
herba Ephedrae with Mel: pungent and slightly bitter, sweet, warm, enter lung and bladder meridians, moisten lung and stop cough.
Ramulus Cinnamomi: pungent and sweet in flavor, warm in nature, enter lung, heart and bladder meridians, induce sweating and relieve muscle, warm and unblock meridians, and strengthen yang and qi.
Rhizoma Pinelliae Preparata: pungent and warm. Enter spleen, stomach and lung meridians. Dry dampness and resolve phlegm.
Fructus trichosanthis: cold nature, sweet and slightly bitter in taste, clear heat and remove phlegm, relieve chest stuffiness and dissipate nodulation, moisten intestines.
Allium macrostemon: pungent and bitter in flavor, warm in nature, enters heart, lung, stomach and large intestine meridians, unblocks yang to dissipate nodulation, moves qi to remove stagnation.
White peony root: pungent and bitter taste, good taste, and spleen meridian entered, and has the effects of warming yang, eliminating dampness, tonifying deficiency, strengthening spleen and stomach, etc.
Dried ginger: pungent in flavor, nature heat, enter spleen, stomach, kidney, heart and lung meridians, warm middle energizer and dispel cold, return yang and activate pulse, warm lung and transform fluid.
Fructus Perillae: pungent in flavor, warm in nature, enters lung and large intestine meridians, and has the actions of lowering qi, resolving phlegm, relieving asthma and moistening intestines.
Root of red-rooted salvia: bitter in property, slightly cold, good in property, and capable of restoring heart and liver meridians, and has the functions of promoting blood circulation, removing blood stasis, dredging meridians, relieving pain, clearing heart fire, relieving restlessness, cooling blood and removing carbuncles
Asarum herb: pungent and warm, enter heart, lung and kidney meridians, dispel exterior cold, dispel wind and alleviate pain, unblock orifices, warm lung and resolve fluid retention.
Chinese magnoliavine fruit: sour, sweet, warm, enter lung, heart and kidney meridians, and have the functions of astringing, supplementing qi, promoting the production of body fluid, tonifying kidney and calming heart.
Honey-fried licorice root: sweet, flat, good for heart, lung, spleen and stomach meridians, and has the effects of invigorating spleen, regulating stomach, invigorating qi and restoring pulse.
The components are matched scientifically and reasonably according to the unique compatibility principle of the traditional Chinese medicines, ephedra and cassia twig are mutually necessary, sweat and cold are dispersed to relieve exterior evil, the ephedra can disperse lung qi to relieve asthma and cough, and the cassia twig warms yang to facilitate the transformation of internal fluid; the red sage root has the effects of activating blood circulation to dissipate blood stasis, cooling blood and resolving carbuncles, and is used for treating chest stuffiness and pain, and mass; the three herbs are monarch drugs. The stem Jiang Xingwen is helpful for removing exterior cold, and asarum is good for channeling, and can not only walk and reach interior; perilla seed has effects of lowering qi and resolving phlegm, relieving cough and asthma, rhizoma Pinelliae Preparata has effects of eliminating dampness and resolving phlegm, harmonizing stomach and lowering adverse qi, and these four ingredients are ministerial drugs. Fructus Trichosanthis has effects of relieving chest stuffiness, clearing heat, eliminating phlegm, and Bulbus Allii Macrostemi Bai Tongyang has effects of resolving hard mass, activating qi-flowing, and removing stagnation, and can smooth qi in chest; the shizandra berry and the white paeony root are compatible with the medicines, and the Chinese magnoliavine fruit and the white paeony root have astringents, are both rigid and soft and have no defect of consuming qi and damaging fluid in the powder; these four herbs are adjuvant drugs. The honey-fried licorice root, radix Glycyrrhizae Praeparata has the effects of invigorating qi and regulating the middle warmer, and harmonizing the herbs, as guiding drugs. Has the effects of dispelling cold, resolving fluid retention, dispersing lung qi, removing blood stasis and resolving phlegm, and can be effectively used for treating acute exacerbation of chronic obstructive pulmonary disease.
The formula of the whole prescription is strict, the treatment rule is clear, the medicines have synergistic effect, the medicine has the functions of dispelling cold, resolving fluid, relieving cough and asthma and the like, is effectively used for treating acute exacerbation stage of slow lung obstruction, has good curative effect and high safety, obtains very good curative effect through experiments, and has the following related experimental data (taking example 1):
1. criteria for selecting cases
Patients are continuously worsened beyond the daily condition, and conventional patients with basic chronic obstructive pulmonary diseases need to be changed, usually in the disease process, acute inflammatory reactions occur, cough, expectoration, shortness of breath and/or wheezing are aggravated in a short period of time, the sputum volume is increased, purulent or mucopurulent symptoms are presented, and the stage of obvious exacerbation of inflammation such as fever can be accompanied. All those with the symptoms can be used as criteria for selecting cases.
2. Diagnostic criteria
The Western diagnosis standard meets the "diagnosis and treatment guidelines for chronic obstructive pulmonary disease" (revised 2021).
The traditional Chinese medicine diagnosis standard refers to the "chronic obstructive pulmonary traditional Chinese medicine diagnosis and treatment guide" specified by the department of medical science of the Chinese traditional Chinese medical society, the department of pulmonary diseases professional committee (2011 edition).
Main symptoms are as follows: cough, wheeze, excessive phlegm, white and thin phlegm, foam, chest distress, inability to lie flat, aversion to cold, white and slippery tongue coating, wiry and tight pulse. Secondary symptoms: phlegm is easy to be fluctuated out, phlegm in the throat is wheeze, no sweat exists, limbs are ache, nasal obstruction, clear nasal discharge and floating pulse.
Diagnosis: (1) cough, wheezing; (2) Aversion to cold, no sweat or soreness of limbs, or nasal obstruction, clear nasal discharge; (3) thin sputum or foam, and easy expectoration of sputum; (4) wheezing in the throat; (5) chest distress and even qi collapse can not be recumbent; (6) The tongue is fat and the tongue is dull, the tongue coating is white and slippery, and the pulse is superficial and tight. The method comprises the steps (1) and (2), and the steps (3) to (6) are added.
3. Treatment regimen
The Chinese medicinal preparation of example 1 is orally taken 30-50ml once, 2 times a day, 1 time each in the morning and evening, 7 days is a treatment course, and 2 treatment courses are counted to obtain the curative effect.
4. Efficacy assessment criteria
Efficacy index = (pre-treatment integral-post-treatment integral)/pre-treatment integral x 100%
Total effective rate = (clinical control + onset + efficacy) number of cases/total number of cases x 100%
And (3) curing: clinical symptoms and signs disappear or disappear basically, the curative effect index is more than or equal to 95%, and various indexes of lung function are recovered to be normal
The effect is shown: the clinical symptoms and physical signs are obviously improved, the curative effect index is more than or equal to 70 percent and less than 95 percent, and various indexes of the lung function are obviously improved
The method is effective: the clinical symptoms and physical signs are all improved, the curative effect index is more than or equal to 30 percent and less than 70 percent, and various indexes of the lung function are improved
Invalidation: no obvious improvement of clinical symptoms and physical signs, curative effect index less than 30% and no change of various indexes of lung function.
5. Statistical treatment
After 104 patients meeting the diagnosis standard take the traditional Chinese medicine composition, 28 patients are cured, 26.9% of the patients take the traditional Chinese medicine composition, 22 patients take obvious effects, 21.2% of the patients take the traditional Chinese medicine composition, 51 patients take effects, 49.0% of the patients take effects, and 3 patients take effects, and 2.9% of the patients take effects. The total effective rate is 97.1 percent, and no toxic or side effect is found in the medication period, which indicates that the medication is safe.
6. Typical cases
Case 1, a man, aged 43 years, had irregular intermittent episodes with cough and asthma for more than 5 years, with exacerbation on coldness, were diagnosed as slow lung obstruction. One week before cold, nasal obstruction, clear nasal discharge, frequent cough, asthma aggravation, a small amount of white phlegm, pale tongue fur and white and slippery fur. The body temperature is 37.8 ℃, the auscultation and breathing sound is low, and the percussion is clear, audible and wheezing. After taking the traditional Chinese medicine composition for 7 days, the symptoms are obviously relieved, the body temperature is 36.6 ℃, and the traditional Chinese medicine composition is continuously taken for 13 days and cured.
The case 2 is that a certain Song and a certain female are 65 years old, cough, white phlegm are not caused by obvious causes before 7 years, the amount of the cough is about 5 ml/day, other symptoms such as night sweat, chest pain, dyspnea and the like are not caused, the cough repeatedly attacks after exogenous wind-cold, and the cough is obvious in autumn and winter. After 2 years, the patient gradually develops short breath after the movement, and the lung function examination is diagnosed as "slow lung obstruction". Before 3 days, the patient has cough, asthma, chest distress, cough with white phlegm, clear nasal discharge, and pale tongue with pale and white fur. The double lung percussion is clear, can be smelled and dispersed in wheeze and coarse wet royalty, and is taken for 6 days, the symptoms are improved, and the double lung percussion is continued to be taken for 13 days to cure.
In case 3, a man is 59 years old, no obvious cause of cough, expectoration, short breath, chest pain and edema of lower limbs is caused 3 years before the complaint. Cough, expectoration (white sticky sputum), shortness of breath, strength, body temperature 38.6 ℃ again after 5 days before fatigue. Dyspnea and dyspnea occur 2 days ago, chest has no malformation, double-lung percussion is clear, heart rate is uniform, double lower limbs have no edema, slow lung obstruction (external cold and internal drinking) is diagnosed, the traditional Chinese medicine composition is taken for 6 days, the symptoms are improved, the body temperature is 36.7 ℃, and the traditional Chinese medicine composition is continuously taken for 14 days and cured.
Case 4 poplar is a certain, male, 71 years old, and the patient has symptoms of runny nose, cough, asthma, cough with white phlegm and chest distress before one week, and aggravates before 3 days. The symptoms are improved after 5 days of taking the traditional Chinese medicine composition of the invention, and the traditional Chinese medicine composition is continuously taken for 12 days to cure after 5 days of taking the traditional Chinese medicine composition, wherein the symptoms are similar to each other when the traditional Chinese medicine composition changes from weather to cold or in winter, and the symptoms are diagnosed as acute exacerbation of the lung caused by slow obstruction (external cold and internal drinking).
The Chinese medicinal composition can be used for treating other lung diseases such as chronic bronchitis, chronic pneumonia and the like which accord with the syndrome of exterior cold and interior fluid retention, and has satisfactory treatment effects, and the Chinese medicinal composition is not specifically listed here.
The same and similar results were obtained by performing the experiments of example 1 and the other examples, respectively, and are not listed here.
7. Conclusion(s)
The traditional Chinese medicine composition disclosed by the invention has the advantages that the monarch, minister, assistant and guide compatibility is scientific and reasonable, the traditional Chinese medicine composition is mutually supported in a synergistic manner, is used for treating wind-cold exterior syndrome, lung failure in dispersing and descending, cold retention in the interior and cold retention in the exterior syndrome, has the effects of dispelling cold and dissolving the retained fluid, relieving cough and asthma, can improve clinical symptoms of patients suffering from acute exacerbation of chronic obstructive pulmonary disease and improve pulmonary functions, can be effectively used for treating other patients suffering from external cold and internal drinking type pulmonary diseases such as chronic pneumonia, chronic bronchitis and the like, has stable and reliable curative effects, does not have any toxic or side effect in the administration period, has good clinical effects, is worthy of being widely popularized, exerts the advantages of traditional Chinese medicines, and has huge economic and social benefits.
Claims (6)
1. A traditional Chinese medicine for treating acute exacerbation of chronic obstructive pulmonary disease is characterized by comprising the following components in parts by weight: 90-110g of ephedra, 80-100g of cassia twig, 108-132g of rhizoma pinellinae praeparata, 109-132g of snakegourd fruit, 90-110g of allium macrostemon, 109-132g of white paeony root, 80-100g of dried ginger, 90-110g of perilla fruit, 135-165g of red-rooted salvia root, 27-33g of asarum, 54-66g of Chinese magnoliavine fruit and 54-66g of honey-fried licorice root, wherein the twelve medicinal materials are decocted for 1 hour by adding water with the volume of 10 times of weight for the first time, filtered and the filtrate is collected for standby; decocting the residues in 8 times of water for 1 hr, wherein the weight and volume are calculated as g solid and mL liquid, filtering, mixing the filtrates, concentrating the filtrate to relative density not lower than 1.02, filtering, packaging, and sterilizing.
2. The traditional Chinese medicine for treating acute exacerbation of chronic obstructive pulmonary according to claim 1, wherein the traditional Chinese medicine is prepared from the following components in parts by weight: 100g of ephedra, 90g of cassia twig, 120g of rhizoma pinellinae praeparata, 120g of snakegourd fruit, 100g of allium macrostemon, 120g of white paeony root, 90g of dried ginger, 100g of perilla seed, 150g of red sage root, 30g of asarum, 60g of shizandra berry and 60g of honey-fried licorice root, wherein the twelve medicinal materials are decocted for 1 hour by adding 10 times of water by weight volume for the first time, filtered and the filtrate is collected for standby; decocting the residues with 8 times of water for 1 hr, filtering, mixing the filtrates, concentrating the filtrate to relative density of not less than 1.02, filtering, packaging, and sterilizing.
3. The traditional Chinese medicine for treating acute exacerbation of chronic obstructive pulmonary according to claim 1, wherein the traditional Chinese medicine is prepared from the following components in parts by weight: 93g of ephedra, 82g of cassia twig, 110g of rhizoma pinellinae praeparata, 129g of snakegourd fruit, 92g of allium macrostemon, 114g of white paeony root, 87g of dried ginger, 93g of perilla seed, 161g of red sage root, 32g of asarum, 57g of shizandra berry and 56g of honey-fried licorice root.
4. The traditional Chinese medicine for treating acute exacerbation of chronic obstructive pulmonary according to claim 1, wherein the traditional Chinese medicine is prepared from the following components in parts by weight: 107g of ephedra, 98g of cassia twig, 130g of rhizoma pinellinae praeparata, 112g of snakegourd fruit, 108g of allium macrostemon, 127g of white peony root, 103g of dried ginger, 107g of perilla seed, 139g of red sage root, 28g of asarum, 63g of shizandra berry and 64g of honey-fried licorice root.
5. The traditional Chinese medicine for treating acute exacerbation of chronic obstructive pulmonary according to claim 1, wherein the traditional Chinese medicine is prepared from the following components in parts by weight: 92g of ephedra, 87g of cassia twig, 131g of rhizoma pinellinae praeparata, 111g of snakegourd fruit, 91g of allium macrostemon, 112g of white peony root, 82g of dried ginger, 92g of perilla seed, 137g of red sage root, 28g of asarum, 55g of shizandra berry and 58g of honey-fried licorice root.
6. The traditional Chinese medicine for treating acute exacerbation of chronic obstructive pulmonary according to claim 1, wherein the traditional Chinese medicine is prepared from the following components in parts by weight: 108g of ephedra, 93g of cassia twig, 109g of rhizoma pinellinae praeparata, 129g of snakegourd fruit, 109g of allium macrostemon, 129g of white peony root, 108g of dried ginger, 108g of perilla seed, 163g of red sage root, 32g of asarum, 65g of schisandra fruit and 62g of honey-fried licorice root.
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| 子栋: "自拟中药方联合西药治疗中重度慢阻肺急性发作期的效果分析", 中国医药科学, vol. 6, no. 04, 25 February 2016 (2016-02-25), pages 40 - 42 * |
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