CN116803448A - Tumor electric field therapeutic instrument and control system - Google Patents
Tumor electric field therapeutic instrument and control system Download PDFInfo
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- CN116803448A CN116803448A CN202211529890.6A CN202211529890A CN116803448A CN 116803448 A CN116803448 A CN 116803448A CN 202211529890 A CN202211529890 A CN 202211529890A CN 116803448 A CN116803448 A CN 116803448A
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- 230000005684 electric field Effects 0.000 title claims abstract description 39
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 30
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 19
- 238000012544 monitoring process Methods 0.000 claims abstract description 13
- 238000010030 laminating Methods 0.000 claims description 13
- 230000008859 change Effects 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 3
- 230000011664 signaling Effects 0.000 claims 1
- 238000011282 treatment Methods 0.000 abstract description 9
- 230000006378 damage Effects 0.000 abstract description 3
- 238000010438 heat treatment Methods 0.000 abstract description 3
- 230000001276 controlling effect Effects 0.000 description 11
- 210000004881 tumor cell Anatomy 0.000 description 5
- 239000000919 ceramic Substances 0.000 description 4
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- 230000007017 scission Effects 0.000 description 4
- 208000003174 Brain Neoplasms Diseases 0.000 description 3
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- 238000012986 modification Methods 0.000 description 2
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- 230000001105 regulatory effect Effects 0.000 description 2
- 102000029749 Microtubule Human genes 0.000 description 1
- 108091022875 Microtubule Proteins 0.000 description 1
- 102000004243 Tubulin Human genes 0.000 description 1
- 108090000704 Tubulin Proteins 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 238000001574 biopsy Methods 0.000 description 1
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- 208000014674 injury Diseases 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 210000005061 intracellular organelle Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 210000004688 microtubule Anatomy 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/08—Arrangements or circuits for monitoring, protecting, controlling or indicating
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Electrotherapy Devices (AREA)
Abstract
The invention discloses a tumor electric field therapeutic apparatus and a control system, comprising: the pulse generator is used for generating a pulse signal, controlling the electronic switch to open and close the electrode through the generated pulse signal, connecting the electrode with the electronic switch through a wire, heating according to the on-off state of the electronic switch, attaching equipment, wherein the electrodes are arranged on two sides of the inside of the attaching equipment, a charger is arranged in the attaching equipment and used for supplying power to the pulse generator and the controller, and the controller is used for controlling the pulse generator and monitoring the temperature; the device divides the electrodes into two groups, realizes the conduction and the switching of the two groups of electrodes through the electronic switch, and the sine wave sent by the pulse generator is periodically changed and the treatment intensity is also periodically changed, so that the single working time of the same electrode is not overlong, and the damage to the skin of a human body is avoided.
Description
Technical Field
The invention relates to the field of medical equipment, in particular to a tumor electric field therapeutic apparatus and a control system.
Background
The tumor treating electric field (Tumor Treating Fields, TTFields/TTF) is one kind of low-strength intermediate frequency alternating electric field capable of preventing spindle microtubule from forming and separating intracellular organelle during cell division and inducing apoptosis during cell division to treat tumor.
TTF has an innovative mechanism of action compared to traditional cancer therapies. Some physiological properties of tumor cells, such as geometry and high frequency mitosis, make them susceptible to TTF. TTF disrupts the normal aggregation of tubulin by exerting directed forces on intracellular polar particles (e.g., macromolecules and organelles). These processes may lead to physical disruption of the cell membrane and apoptosis. At the end of cell mitosis, the structural morphology of the cleavage groove can lead to uneven distribution of electric fields around the cleavage groove, meanwhile, under the influence of TTF, the electric field intensity at the cleavage groove is obviously enhanced, and charged substances in cells move to the cleavage groove, so that the formation of cell structures is disturbed or even destroyed, and finally, the cell division failure can be caused, and the cell death is realized.
TTF is a brand-new tumor treatment method following treatment means such as surgery, radiotherapy, chemotherapy, etc., and is theoretically effective on all solid tumors. The in vitro experimental study has now demonstrated that: TTF has a remarkable inhibitory effect on proliferation of various tumor cell lines, but the existing TTF cannot perform biopsy on some tumors, such as brain tumors, before operation, and cannot determine the electric field intensity required to be set by the tumor cell type when the TTF is used for treatment.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a tumor electric field therapeutic apparatus and a control system.
In order to achieve the above purpose, the present invention adopts the following technical scheme: a tumor electric field therapeutic apparatus comprising:
a pulse generator for generating pulse signals and controlling the electronic switch to open and close by the generated pulse signals
The electrode is connected with the electronic switch through a lead and is heated according to the on-off state of the electronic switch,
laminating equipment, inside both sides are equipped with the electrode, laminating equipment is inside to be equipped with the charger, be used for pulser and controller carry out the power supply, the controller is used for control pulser and carry out temperature monitoring.
As a further description of the above technical solution: the electrodes are divided into two groups, and the two groups of electrodes are positioned at different positions of the laminating equipment.
As a further description of the above technical solution: the arrangement mode of any group of the electrodes is a linear array or a circumferential array, a plurality of temperature sensors are arranged in the array of the electrodes, and the number of the temperature sensors is 8.
As a further description of the above technical solution: the electrode is characterized in that a round hole is formed in one side of the electrode, a thermistor is placed in the round hole, the thermistor is connected with the controller through a wire, and detected temperature data are sent to the controller for temperature monitoring.
As a further description of the above technical solution: the pulse signal is a sine wave of 100-300kHz, the output is switched between the two groups of electrodes through the electronic switch, and the output is switched to the other group after the work is completed within a preset time.
Still include a tumour electric field control system, control system is applicable to the therapeutic instrument of any one of the above-mentioned technical scheme, include:
the control module comprises a first control unit and a second control unit, and the first control unit and the second control unit are used for alternately controlling in a preset time;
the pulse generation module is used for receiving the output signals sent by the control module and outputting corresponding pulse signals according to the corresponding signals;
the timing module can set preset time, and after the preset time, the set clock signal can be sent to the control module;
and the temperature monitoring module monitors the temperature of the electrode and feeds back detection information to the control module.
As a further description of the above technical solution: the first control unit is a frequency control unit, and controls the pulse generation module to output a corresponding pulse signal by controlling the output frequency, and the larger the output frequency of the first control unit is, the smaller the phase difference of the pulse signal output by the pulse generation module is.
As a further description of the above technical solution: the second control unit is a field intensity control unit and controls the pulse generation module to generate a pulse signal corresponding to the type through controlling the electric field intensity, and the second control unit enables the amplitude of the output signal of the pulse generator to change through controlling the voltage, and the larger the field intensity is, the larger the corresponding output amplitude is.
As a further description of the above technical solution: the timing module is used for setting preset time and over-frequency warning time, wherein the preset time is 0.5-1.5 seconds, and the over-frequency warning time is 2-3 minutes.
As a further description of the above technical solution: the control system also comprises a warning module, and the warning module alarms in the time-counting module over-frequency warning time.
The technical scheme has the following advantages or beneficial effects:
1. the pulse generator is arranged on the laminating equipment, and the controller enables the pulse generator to send sine waves with different frequencies to control the on-off of the electronic switch, so that the circuit is communicated with the electrode, and a therapeutic electric field can be formed for working.
2. The electrodes are divided into two groups, the conduction switching of the two groups of electrodes is realized through the electronic switch, the sine wave sent by the pulse generator is periodically changed, and the treatment intensity liquid level is periodically changed, so that the single working time of the same electrode is not excessively long, and the damage to the skin of a human body is avoided.
3. The thermistor is arranged at the electrode, whether the electrode works normally or not is judged by monitoring the current resistance temperature, if not, the electrode is warned by the warning module, and after the warning time is exceeded, the electrode is not converted into normal, and then the control module automatically performs power-off protection.
Drawings
FIG. 1 is a schematic diagram of a tumor electric field therapeutic apparatus according to the present invention;
FIG. 2 is a schematic diagram of a control system according to the present invention;
FIG. 3 is a graph of a sinusoidal waveform of the output of the pulse generator of the present invention;
FIG. 4 is a graph of a sinusoidal waveform of the pulse generator output after a phase change in accordance with the present invention;
FIG. 5 is a graph of another sinusoidal waveform of the output of the pulse generator of the present invention;
FIG. 6 is a graph of a sinusoidal waveform after another amplitude variation of the pulse generator output according to the present invention;
legend description:
1. a pulse generator; 2. an electrode; 3. a laminating device; 4. a controller; 5. a control module; 51. a first control unit; 52. a second control unit; 6. a pulse generation module; 7. a timing module; 8. a temperature monitoring module; 9. and a warning module.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Referring to fig. 1, one embodiment provided by the present invention: a tumor electric field therapeutic apparatus comprising: the pulse generator 1 is used for generating pulse signals, controlling the electronic switch to open and close the electrode 2 through the generated pulse signals, connecting the electronic switch through a wire, heating according to the on-off of the electronic switch, laminating equipment 3, wherein the electrodes 2 are arranged on two sides of the inside of the laminating equipment 3, a charger is arranged inside the laminating equipment 3 and used for supplying power to the pulse generator 1 and the controller 4, and the controller 4 is used for controlling the pulse generator 1 and monitoring the temperature.
In this embodiment, the attaching device 3 may be placed on the surface of a human body, the pulse generator 1 and the controller 4 are installed inside the attaching device 3, one surface, which is in contact with the human body, of the inner side of the attaching device 3 is provided with a plurality of electrodes 2, the controller 4 controls the pulse generator 1 to send out sine waves, so that the electronic switch is switched on and off to control the electric field intensity output by the electrodes 2, thereby treating the human body, the controller 4 can also receive the temperature signal fed back by the temperature sensor at the electrodes 2, determine the current heating temperature range of the electrodes, specifically, the temperature range is kept at 37±2 ℃, the electrodes 2 are ceramic electrodes, and the ceramic electrodes are insulated from the outside, so that the electric leakage danger is avoided; the portable battery can be used for supplying power, so that the portable battery is convenient for a patient to move or go out during treatment, and the battery can be provided with an electric quantity display so that the patient can check at any time before using the portable battery.
Referring to the drawings, in a specific embodiment, the attaching device 3 is designed as a head-mounted device, and may be in a hat shape, and may be used for treating brain tumor or other undetermined tumor, where the plurality of electrodes 2 are divided into two groups, and the two groups of electrodes 2 are located at different positions of the attaching device 3; the arrangement mode of any group of electrodes 2 is a linear array or a circumferential array, a plurality of temperature sensors are arranged in the array of the electrodes 2, and the number of the temperature sensors is 8; a round hole is formed in one side of the electrode 2, a thermistor is arranged in the round hole and connected with the controller 4 through a wire, and detected temperature data are sent to the controller 4 for temperature monitoring.
In this embodiment, the arrangement mode of each group of electrodes 2 is 3 rows and 3 columns, and the two groups of electrodes are respectively arranged at the inner lining of the cap-shaped laminating device 3, specifically, the two groups of electrodes can be the left side and the right side or the front side and the back side of the cap-shaped laminating device 3, and when the alternating electric field frequency is about 200kHz and the impedance is 50-100 Ω, the ceramic electrodes and the human tissues can be heated to cause the injury of patients, so that the current is adjusted to control the temperature within the acceptable range of the patients. Through placing the thermistor in the center opening of each electrode ceramic, each electrode array is provided with 8 thermistors, signals are transmitted to a hub through shielding wires to carry out digital-to-analog conversion, the signals are analyzed and transmitted to the pulse generator 1, and the output current is regulated by the pulse generator 1 according to temperature feedback.
The pulse signal is 100-300kHz sine wave, the output is switched between two groups of electrodes 2 through an electronic switch, and the output is switched to the other group after the work is completed within a preset time.
In this embodiment, the output waveform of the pulse signal is set to be a sine wave of 100-300kHz, and the switching of the electronic switch can be controlled, so that the output sine wave is alternately transmitted to the two groups of electrodes, and the electrodes generate an electric field according to the output current corresponding to the corresponding wavelength, so as to perform TTF treatment.
Electrode cable: since there are 8 temperature sensors per electrode array and one pulse output, the electrode cable requires 10 core shielded cables. Main cable: the 4 electrodes need 4 output lines, the temperature signal is digital-to-analog converted, encryption, 2 communication lines are needed for transmission, and a power line is needed for a hub, so that an 8-core shielding cable is needed for a main cable.
Referring to fig. 2, the present invention further provides an embodiment of a tumor electric field control system, where the control system is applicable to the therapeutic apparatus according to any one of the above technical solutions, and includes:
a control module 5 including a first control unit 51 and a second control unit 52, the first control unit 51 and the second control unit 52 alternately controlling for a predetermined time;
the pulse generation module 6 is used for receiving the output signal sent by the control module 5 and outputting a corresponding pulse signal according to the corresponding signal;
the timing module 7 can set a preset time, and can send a set clock signal to the control module 5 after the preset time;
the temperature monitoring module 8 monitors the temperature of the electrode and feeds back detection information to the control module 5.
In this embodiment, a predetermined time is set by the timing module 7, a set clock signal is sent to the control module 5, the control module 5 alternately sends output signals of the first control unit 51 and the second control unit 52 to the pulse generation module 6 according to the clock signal, the pulse generation module 6 sends corresponding sine waves according to the output signals to control the electrode 2 to generate electric fields with different intensities, the electrode 2 is provided with the temperature monitoring module 8, the temperature generated after the electrode 2 works can be fed back to the control module 5, the control module 5 judges whether the current working process is normal or not, if not, the control module 5 controls the warning module 9 to give an alarm, the warning is carried out in the overtime warning time set by the timing module 7, and the control module 5 automatically carries out power-off protection once the warning time is exceeded and the power is not regulated to be normal.
Referring to fig. 3 to 6, the first control unit 51 is a frequency control unit, and controls the pulse generation module 6 to output a corresponding pulse signal by controlling the output frequency, and the greater the output frequency of the first control unit 51, the smaller the phase difference of the pulse signal output of the pulse generation module 6; the second control unit 52 is a field intensity control unit, and controls the pulse generation module 6 to generate a pulse signal corresponding to the type by controlling the electric field intensity, and the second control unit 52 changes the amplitude of the output signal of the pulse generator by controlling the voltage, and the larger the field intensity, the larger the corresponding output amplitude.
In a specific embodiment, since some tumors cannot be biopsied before operation, such as brain tumor, the type of tumor cells cannot be judged, but the pulse generator 1 sends the treatment frequency between 100kHz and 300kHz for scanning, as shown in fig. 3, and can also scan between 300kHz and 100kHz, as shown in fig. 4, and the frequency is adjusted to change the phase difference of sine waves so as to basically cover most of the known tumor cells; the electric field generated by the pulse generator 1 through the electrode 2 is attenuated after passing through the body surface of the human body, the electric field intensity reaching the tumor position is changed due to different tumor positions, the treatment effect of the electric field intensity is reduced at the moment, but when the electric field intensity is higher than 3.0V/cm, the risk of over-frequency of the therapeutic apparatus is increased, the intensity of the electric field is adjusted through the control module 5, the therapeutic electric field intensity is changed periodically through the matching of the frequency and the intensity, the frequency and the intensity output by the pulse generator 1 are changed in the period, the change period is 1 second, the intensity is from low to high, the amplitude of the sine wave is gradually increased, the intensity is from high to low, and the amplitude of the sine wave is gradually reduced, as shown in fig. 6.
The timing module 7 is used for setting preset time and over-frequency warning time, wherein the preset time is 0.5-1.5 seconds, and the over-frequency warning time is 2-3 minutes.
Specifically, the control system further comprises a warning module 9, and the warning module alarms in the overtime warning time of the timing module 7.
Finally, it should be noted that: the foregoing description is only illustrative of the preferred embodiments of the present invention, and although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described, or equivalents may be substituted for elements thereof, and any modifications, equivalents, improvements or changes may be made without departing from the spirit and principles of the present invention.
Claims (10)
1. A tumor electric field therapeutic apparatus, comprising:
a pulse generator (1) for generating a pulse signal and controlling the electronic switch to be opened and closed by the generated pulse signal
The electrode (2) is connected with the electronic switch through a lead and is heated according to the on-off state of the electronic switch,
laminating equipment (3), inside both sides are equipped with electrode (2), laminating equipment (3) are inside to be equipped with the charger, are used for give pulser (1) and controller (4) carry out the power supply, controller (4) are used for control pulser (1) and carry out temperature monitoring.
2. The tumor electric field therapeutic apparatus according to claim 1, wherein: the electrodes (2) are divided into two groups, and the two groups of electrodes (2) are positioned at different positions of the laminating equipment (3).
3. The tumor electric field therapeutic apparatus according to claim 1, wherein: the arrangement mode of any group of the electrodes (2) is a linear array or a circumferential array, a plurality of temperature sensors are arranged in the array of the electrodes (2), and the number of the temperature sensors is 8.
4. The tumor electric field therapeutic apparatus according to claim 1, wherein: a round hole is formed in one side of the electrode (2), a thermistor is placed in the round hole, the thermistor is connected with the controller (4) through a wire, and detected temperature data are sent to the controller (4) for temperature monitoring.
5. The tumor electric field therapeutic apparatus according to claim 1, wherein: the pulse signal is a sine wave of 100-300kHz, the output is switched between the two groups of electrodes (2) through the electronic switch, and the output is switched to the other group after the work is completed within a preset time.
6. A tumor electric field control system adapted for use in the therapeutic apparatus of any one of claims 1-5, comprising:
a control module (5) including a first control unit (51) and a second control unit (52), the first control unit (51) and the second control unit (52) alternately controlling for a predetermined time;
the pulse generation module (6) is used for receiving the output signals sent by the control module and outputting corresponding pulse signals according to the corresponding signals;
the timing module (7) can set preset time, and can send the set clock signal to the control module (5) after the preset time;
and the temperature monitoring module (8) monitors the temperature of the electrode and feeds back detection information to the control module (5).
7. The tumor electric field control system according to claim 6, wherein: the first control unit (51) is a frequency control unit, and controls the pulse generation module (6) to output corresponding pulse signals by controlling the output frequency, and the larger the output frequency of the first control unit (51), the smaller the phase difference of the pulse signal output of the pulse generation module (6).
8. The tumor electric field control system according to claim 6, wherein: the second control unit (52) is a field intensity control unit, the pulse generation module (6) generates a pulse signal corresponding to the type through controlling the electric field intensity, the second control unit (52) enables the amplitude of the output signal of the pulse generator to change through controlling the voltage, and the larger the field intensity is, the larger the corresponding output amplitude is.
9. The tumor electric field control system according to claim 6, wherein: the timing module (7) is used for setting preset time and over-frequency warning time, wherein the preset time is 0.5-1.5 seconds, and the over-frequency warning time is 2-3 minutes.
10. The tumor electric field control system according to claim 6, wherein: the control system also comprises a warning module (9), and the warning module alarms in the overtime warning time of the timing module (7).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211529890.6A CN116803448A (en) | 2022-11-30 | 2022-11-30 | Tumor electric field therapeutic instrument and control system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211529890.6A CN116803448A (en) | 2022-11-30 | 2022-11-30 | Tumor electric field therapeutic instrument and control system |
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| Publication Number | Publication Date |
|---|---|
| CN116803448A true CN116803448A (en) | 2023-09-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211529890.6A Pending CN116803448A (en) | 2022-11-30 | 2022-11-30 | Tumor electric field therapeutic instrument and control system |
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| Country | Link |
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| CN (1) | CN116803448A (en) |
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- 2022-11-30 CN CN202211529890.6A patent/CN116803448A/en active Pending
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