CN116763505A - Fixing assembly and application thereof - Google Patents
Fixing assembly and application thereof Download PDFInfo
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- CN116763505A CN116763505A CN202310818026.6A CN202310818026A CN116763505A CN 116763505 A CN116763505 A CN 116763505A CN 202310818026 A CN202310818026 A CN 202310818026A CN 116763505 A CN116763505 A CN 116763505A
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- bone
- plate body
- microporous
- plate
- arc
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- 210000000988 bone and bone Anatomy 0.000 claims abstract description 97
- 230000007547 defect Effects 0.000 claims abstract description 45
- 230000003014 reinforcing effect Effects 0.000 claims description 19
- 229910003460 diamond Inorganic materials 0.000 claims description 6
- 239000010432 diamond Substances 0.000 claims description 6
- 230000001788 irregular Effects 0.000 claims description 5
- 230000000149 penetrating effect Effects 0.000 claims description 5
- 238000003825 pressing Methods 0.000 claims description 2
- 230000001054 cortical effect Effects 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 10
- 238000011065 in-situ storage Methods 0.000 abstract description 8
- 230000008468 bone growth Effects 0.000 abstract description 5
- 230000007774 longterm Effects 0.000 abstract description 5
- 238000007634 remodeling Methods 0.000 abstract description 4
- 210000004872 soft tissue Anatomy 0.000 abstract description 4
- 235000016709 nutrition Nutrition 0.000 abstract description 3
- 230000008439 repair process Effects 0.000 abstract description 3
- 230000036770 blood supply Effects 0.000 abstract description 2
- 230000035764 nutrition Effects 0.000 abstract description 2
- 230000005540 biological transmission Effects 0.000 abstract 1
- 230000010354 integration Effects 0.000 abstract 1
- 230000008929 regeneration Effects 0.000 abstract 1
- 238000011069 regeneration method Methods 0.000 abstract 1
- 239000011148 porous material Substances 0.000 description 14
- 239000007943 implant Substances 0.000 description 13
- 230000012010 growth Effects 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 230000006378 damage Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 208000010392 Bone Fractures Diseases 0.000 description 3
- 229910000883 Ti6Al4V Inorganic materials 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 238000005728 strengthening Methods 0.000 description 3
- 206010020649 Hyperkeratosis Diseases 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 238000002591 computed tomography Methods 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 239000012765 fibrous filler Substances 0.000 description 2
- 238000009499 grossing Methods 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 238000010883 osseointegration Methods 0.000 description 2
- 230000011164 ossification Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 241000254032 Acrididae Species 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- 206010040007 Sense of oppression Diseases 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000004938 stress stimulation Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Abstract
The invention belongs to the technical field of bone defect repair and relates to a fixing assembly and application thereof, wherein the fixing assembly comprises two arc-shaped microporous plates, each microporous plate comprises a plate body formed by sequentially connecting a plurality of microporous structural units, a frame structure fixedly connected with the plate body is arranged at the edge of the plate body, and the microporous plates are used for covering segmental bone defect positions to block soft tissue from growing in and reserve a growing space of new bone so that the new bone tissue can grow in situ at the defect positions. The invention can reserve the cortical bone growth space, guide the in-situ regeneration and remodeling of the cortical bone, shield the soft tissue from growing in, strengthen the blood supply and nutrition transmission capacity of the defect part, strengthen the structural strength of the transitional part, reduce the stress concentration effect of the tail end, provide early support for patients, form the new bone in situ at the bone defect part, and carry out mechanical remodeling in situ to form the new bone with mechanical strength, and the cortical bone and the micropore plate form the effective bone integration to strengthen the long-term stability.
Description
Technical Field
The invention belongs to the technical field of bone defect repair, and particularly relates to a fixing component and application thereof.
Background
Bone is a load-bearing organ of the human body and is involved in multiple physiological functions of the human body as an immune hematopoiesis organ, so that the effect of the bone is not small. However, more than 300 thousands of cases of bone defects are produced each year due to high energy injury and bone diseases, wherein when the bone defects are small injuries, such as cracks and fractures, they can heal themselves, and when large areas of bone are lost or resected and cannot heal themselves, the bone defects are called critical bone defects, and limb reconstruction for the critical bone defects is a very challenging orthopedic problem clinically.
At present, the gold standard for treating critical bone defects is to perform autologous bone grafting after mechanical stabilization, however, autologous bone grafting suffers from the defects of damage of donor sites and insufficient material sources, and cannot well cope with large-segment bone defects. In addition to bone grafting, the use of surgical techniques to treat critical bone defects is a common practice for clinicians, and mainly includes bone movement and Masquelet techniques, which have long treatment times, the average bone growth per cm of bone movement is substantially over one month, and the Masquelet technique is subjected to a secondary operation, which is performed after 6-8 weeks of the primary operation, so that the time period is relatively long. The common clinical proposal is to use Ti6Al4V filling implant for instantly restoring limb stability, and implant the implant into the position of bone defect to fill the bone defect so as to complete the repair work.
However, since the elastic modulus of the implant is too high (Ti 6Al4V:114GPa, cortical bone: 3-30 GPa), stress shielding effect is caused, that is, stress is mainly borne by the implant, and bone around the implant is easily collapsed due to lack of stress stimulation. The conversion of a solid Ti6Al4V filled implant into a microporous Ti6Al4V filled implant can reduce the elastic modulus and the micropores can provide guidance for bone growth, but the micropores can only guide several millimeters of bone ingrowth and cannot guide the new bone to grow completely full of the filled implant. Most of the new bone takes up the space of the original bone tissue due to the micropore filling prosthesis, so that the callus can only be formed on the outer surface of the micropore filling implant, the mechanical strength of the formed callus is far lower than that of normal bone, and the support effect is not provided, so that the long-term stability of the implant after implantation is insufficient, and even serious clinical consequences such as fracture around the implant can be caused.
Disclosure of Invention
In view of the above, the invention provides a fixing component and application thereof, wherein the fixing component comprises two arc-shaped micro-pore plates, each micro-pore plate comprises a plate body formed by sequentially connecting a plurality of micro-pore structural units, a frame structure fixedly connected with the plate body is arranged at the edge of the plate body, and the micro-pore plates are used for coating a segmental bone defect part to block the growth of soft tissues and reserve a growth space of new bone so that the new bone tissues can grow in situ at the defect part. The direction of the growth of the new bone tissue is guided by the micropore structure unit on the micropore plate, so that the stress direction of the new bone is consistent with the direction of the original cortical bone, and the new bone can be stimulated by more stress because the micropore structure unit has no stress shielding effect, the growth and the remodeling process of the new bone are promoted, and the problem of poor long-term stability caused by insufficient space and insufficient mechanical strength of the new bone after the implant is implanted is solved by the fixing component.
The technical scheme of the invention is as follows:
a microplate comprising:
the two arc-shaped microporous plates are oppositely arranged, the enclosed space is used for wrapping the bone defect part of a human body, the microporous plates comprise plate bodies, the plate bodies are formed by sequentially and fixedly connecting a plurality of microporous structure units, the edges of the plate bodies are provided with frame structures, and the frame structures are fixedly connected with the plate bodies;
the connecting structure is arranged on the plate body and is used for fixing the plate body with a human body.
Preferably, the microporous structure unit is one or a combination of a plurality of body centered cubic structure, diamond structure, spiral icosahedron, basic beam unit, irregular microporous structure or three-period extremely small curved surface micropores.
Preferably, the plate further comprises a reinforcing structure arranged at the middle section of the plate body, wherein the reinforcing structure is sleeved on the plate body and used for reinforcing the strength of the plate body and pressing the plate body into a preset shape.
Preferably, the reinforcing structure comprises a substrate, a through groove for penetrating the plate body is formed in the surface of the substrate, and the through groove is arc-shaped.
Preferably, one side of the substrate, which is close to the inner concave surface of the through groove, is an arc surface, and the arc surface is coaxial with the through groove.
Preferably, the frame structure comprises at least two side bars arranged in parallel, and a plurality of connecting rods for connecting the side bars into an integral structure are arranged between the side bars.
Preferably, two ends of the plate body, which deviate from the reinforcing structure, are arc-shaped outwards.
Preferably, the connecting structure comprises a plurality of mounting holes formed in the plate body, and the mounting holes are used for penetrating through the connecting pieces.
The use of a fixation assembly as described above in the reconstruction of a limb with a critical bone defect.
Compared with the prior art, the fixing component and the application thereof provided by the invention have the following beneficial effects:
1. the two arc-shaped micropore plates are used in combination to wrap the bone defect part, and the fixing component with the micropore structural unit can be used for treating segmental bone defects and can be used for cutting down the ground immediately, so that the problems of slow bone defect treatment process of a Masquelet technology and a bone moving technology can be solved;
2. the micro-pore plate and the residual cortical bone form osseointegration, so that the fixing effect is better, and the problems of stress shielding and easy breakage when the existing long-term steel plate is fixed can be solved;
3. the adoption of the fixing component with the micropore structural unit for treating the segmental bone defect can solve the problem that the existing bone defect filling block prosthesis lacks cortical bone ingrowth space;
4. the micropore structure unit can guide the growth of new bone, can allow nutrient components, blood vessels and the like to enter into a defect area to create a bone microenvironment for bone formation, and can prevent surrounding fibrous connective tissue from entering into bone defect to form fibrous fillers;
5. the micropore plate has the effect of self-fixing, and the existing prosthesis is used for treating bone defect and needs to be fixed in an auxiliary mode, so that the micropore plate can be fixed in a self-fixing mode at early stage without external auxiliary fixation, and has a self-fixing effect after bone grows into the micropore plate, and the bone defect removing screw also has a firm fixing effect, so that the bone defect removing device is high in practicability and worthy of popularization.
Drawings
FIG. 1 is a schematic view of a fastening assembly of the present invention;
FIG. 2 is a schematic diagram of the overall structure of a microplate of the present invention 1;
FIG. 3 is a schematic view of the overall structure of a microplate of the present invention 2;
FIG. 4 is a schematic structural view of a reinforcing structure of the present invention 1;
FIG. 5 is a schematic structural view of the reinforcing structure of the present invention 2;
FIG. 6 is a schematic diagram of a frame structure according to the present invention;
FIG. 7 is a schematic diagram of the structure of a spiral twenty-tetrahedron of the present invention;
FIG. 8 is a schematic structural view of an irregular microporous structure according to the present invention;
FIG. 9 is a schematic view of a diamond structure according to the present invention;
fig. 10 is a schematic structural view of a body centered cubic structure of the present invention.
Detailed Description
The present invention provides a fixing assembly and application thereof, and the present invention is described below with reference to the schematic structural diagrams of fig. 1 to 10.
Example 1
As shown in fig. 1, the fixing component provided by the invention comprises two arc-shaped micro-pore plates which are oppositely arranged, wherein a space formed by encircling the two arc-shaped micro-pore plates is used for wrapping a bone defect part of a human body, and a structure for guiding the growth of new bone is formed.
As shown in fig. 2 and 3, the structure of the microplate includes a plate body 1, the plate body 1 is formed by sequentially and fixedly connecting a plurality of microporous structure units 102, a frame structure 101 is arranged at the edge of the plate body 1, the frame structure 101 is fixedly connected with the edge structure part of the plate body 1, and the frame structure 101 is shown in fig. 6. The frame structure 101 includes at least two parallel strips, and a plurality of connecting rods for connecting the strips into an integral structure are disposed between the strips. The frame structure 101 wraps the board body 1 therein to form an integral whole structure.
The plate body 1 formed by sequentially and fixedly connecting the microporous structural units 102 is wrapped at the bone defect part of the human body, so that nutritional ingredients, blood vessels and the like can be allowed to enter the bone defect area to create a bone microenvironment for bone formation, and the microporous structural units can prevent surrounding fibrous connective tissues from entering the bone defect to form fibrous fillers.
Wherein, as shown in fig. 7 to 10, the microporous structure unit 102 is one or a combination of a plurality of body centered cubic structure, diamond structure, spiral icosahedron, basic beam unit, irregular microporous structure or three-period extremely small curved micropores. When several of them are selected for combination, a space arrangement mode, such as a body-centered cubic structure, a diamond structure, and a spiral icosahedron, may be selected, so that the reliability of the structure is enhanced.
As shown in fig. 1, a connection structure 3 is further disposed on the board body 1, and the connection structure 3 is located at two ends away from the reinforcing structure 2, and is used for fixing the board body 1 with a human body. The connecting structure 3 comprises a plurality of mounting holes formed in the plate body 1, the mounting holes are used for penetrating connecting pieces, and the connecting pieces can be bone nails or screws so as to fix the position of the plate body 1 relative to a human body and prevent the plate body 1 from moving to cause dislocation of a fixing assembly and a bone defect part of the human body.
In addition, still including setting up the additional strengthening 2 at the middle section of plate body 1, additional strengthening 2 suit sets up the middle section at plate body 1 for strengthen the intensity of plate body 1, will simultaneously the structure oppression of plate body 1 is into the shape of predetermineeing.
As shown in fig. 4 and 5, the reinforcing structure 2 includes a substrate 201, and through grooves are formed on the surface of the substrate 201, and the through grooves are arc-shaped so as to facilitate the micro-porous plate to pass through.
The side of the substrate 201 near the inner concave surface of the through groove is an arc surface, and the arc surface is coaxial with the through groove.
The two arc-shaped micro-pore plates are respectively penetrated in the corresponding reinforcing structures 2, and the inner concave surfaces of the through grooves on the two reinforcing structures 2 are oppositely arranged so that the two micro-pore plates form a cylinder body, thereby being convenient for forming a structure for wrapping the bone defect part.
The both ends that plate body 1 deviate from additional strengthening 2 are the arc of evagination, and the arc structure can furthest avoid the injury to the patient to facilitate the use improves the travelling comfort that the patient used.
Use of a fixation assembly in limb reconstruction of critical bone defects.
The design method of the micro-pore plate in the fixing component provided by the invention comprises the following steps:
1. firstly, CT scanning is carried out on the affected limb and the healthy limb of a patient, and three-dimensional reconstruction is carried out on the affected limb and the healthy limb:
patient CT data in DICOM format obtained by CT scanning is imported into Mimic19.0 software, gray values of different tissues are different, gray value threshold dividing functions in the software are utilized to highlight and extract gray value thresholds of affected bones and healthy bones, then three-dimensional reconstruction is conducted on the affected bones and the healthy bones, repairing and smoothing are conducted on the obtained bones through a smoothing and repairing function in the software, models of the affected bones and the healthy bones are derived, and a file is derived to be in a stl format.
2. The obtained affected bone and healthy bone are imported into Rhino7 software in stl format, and the bones are re-divided by using a quadrilateral mesh tool and converted into multiple curved surfaces.
3. Determining the size, the upper limit and the lower limit of each microplate in the fixed assembly:
and a proper number of screw hole sites are reserved outside the size of the bone defect site of the affected side bone to serve as a connecting structure 3, and the size, the upper limit and the lower limit of each micro-pore plate in the fixing assembly are set by taking the size of the screw hole sites and the defect site as boundaries.
4. Creating an arcuate microplate:
and drawing an arc line on the upper and lower boundary parts of the micro-pore plate by utilizing the Curve tool in the rho software according to the outer diameter of the residual bone of the affected side bone. And drawing the trace of the micro-pore plate by using the Curve tool by taking the outline shape of the healthy side bone as a reference. Creating a basic curved surface of the micro-plate by using a Sweep tool in the rho software, obtaining a solid by using a curved surface offset tool to the obtained basic curved surface of the micro-plate, and subtracting the screw hole positions by Boolean operation to obtain the solid micro-plate.
5. Creating a microporous structural unit:
the microporous structural elements may take a variety of forms including, but not limited to, body centered cubic structures, diamond structures, spiral icosahedrons, basic beam elements, irregular microporous structures, or combinations of one or more of the three period very small curved micropores, where basic beam elements are demonstrated: firstly, drawing a wire frame of a basic beam unit in a rho, scaling the basic beam unit to a proper size by utilizing a Scale function in a parameterized plug-in Grasshop, carrying out three-dimensional array on the basic beam unit by utilizing an array function, and constructing a solid micropore structure unit by utilizing a multi-pipe function.
6. Arc-fused microporous plate and microporous structure unit
And establishing a mapping relation between the micropore structural unit and the arc-shaped micropore plate by utilizing a parameterized plug-in Grasshopper in the Rhino to obtain a wire frame structure of the arc-shaped micropore plate, and constructing a solid structure by utilizing the Multipipe to obtain the arc-shaped micropore plate.
7. Arc-shaped micro-pore plate reinforcing arrangement:
the middle section of the arc-shaped microporous plate is sleeved with the reinforcing structure 2, screw hole parts are arranged on two sides of the arc-shaped microporous plate, and a frame structure for the reinforcing structure is arranged on the edge of the arc-shaped microporous plate.
The invention provides a fixing component and application thereof, wherein two arc-shaped micropore plates are adopted in the fixing component to wrap a bone defect part, the design of a cortical bone outer wrapping type arc-shaped plate prosthesis for reserving a cortical bone growth space is adopted for the first time, an arc-shaped plate micropore structure is adopted to guide cortical bone to regenerate and remodel in situ, soft tissue ingrowth is shielded, blood supply and nutrition conveying capacity of the defect part are enhanced, and a fusiform structure is adopted at the tail end to reduce stress concentration effect.
The fixing component has proper strength, can provide early support for patients and enables the patients to bear load in early stages; the micropore plate has elastic modulus similar to that of cortical bone, a new bone growth part is reserved, new bone can be formed in situ at a bone defect part, mechanical remodeling is carried out in situ to form new bone with mechanical strength, and the intact cortical bone at the upper and lower ends of the fracture can form an effective osseointegration with the micropore plate to enhance long-term stability, so that the bone fracture plate has strong practicability and is worthy of popularization.
The foregoing disclosure is only illustrative of the preferred embodiments of the present invention, but the embodiments of the present invention are not limited thereto, and any variations within the scope of the present invention will be apparent to those skilled in the art.
Claims (9)
1. A securing assembly, comprising:
the two arc-shaped microporous plates are oppositely arranged, a space formed by surrounding the two arc-shaped microporous plates is used for wrapping a bone defect part of a human body, the microporous plates comprise a plate body (1), the plate body (1) is formed by sequentially and fixedly connecting a plurality of microporous structure units (102), a frame structure (101) is arranged at the edge of the plate body (1), and the frame structure (101) is fixedly connected with the plate body (1);
the connecting structure (3) is arranged on the plate body (1) and is used for fixing the plate body (1) with a human body.
2. The fixation assembly of claim 1, wherein the microporous structural element (102) is one or a combination of more of a body centered cubic structure, a diamond structure, a spiral twenty tetrahedron, a basic beam element, an irregular microporous structure, or a tricycled very small curved microporous.
3. The fixing assembly according to claim 1, further comprising a reinforcing structure (2) arranged at the middle section of the plate body (1), wherein the reinforcing structure (2) is sleeved on the plate body (1) and is used for reinforcing the strength of the plate body (1) and pressing the plate body (1) into a preset shape.
4. A fixing assembly according to claim 3, characterized in that the reinforcing structure (2) comprises a base plate (201), the surface of the base plate (201) being provided with through grooves for penetrating the plate body (1), the through grooves being arc-shaped.
5. The fixation assembly of claim 4, wherein a side of the base plate (201) adjacent to the concave surface of the through slot is a cambered surface and the cambered surface is coaxial with the through slot.
6. The fastening assembly of claim 5, wherein the frame structure (101) comprises at least two parallel-disposed side bars, and a plurality of connecting bars for connecting the side bars into an integral structure are disposed between the side bars.
7. The fastening assembly according to claim 6, characterized in that the ends of the plate body (1) facing away from the reinforcing structure (2) are convexly curved.
8. The fixing assembly according to claim 7, wherein the connecting structure (3) comprises a plurality of mounting holes formed in the plate body (1) for penetrating connecting members.
9. Use of the fixation assembly of claim 8 in limb reconstruction of critical bone defects.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310818026.6A CN116763505A (en) | 2023-07-05 | 2023-07-05 | Fixing assembly and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310818026.6A CN116763505A (en) | 2023-07-05 | 2023-07-05 | Fixing assembly and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116763505A true CN116763505A (en) | 2023-09-19 |
Family
ID=88009807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310818026.6A Pending CN116763505A (en) | 2023-07-05 | 2023-07-05 | Fixing assembly and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116763505A (en) |
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2023
- 2023-07-05 CN CN202310818026.6A patent/CN116763505A/en active Pending
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