CN1167432C - Hypoglycemic life-elongating tablet and its preparing process - Google Patents

Abstract

The present invention relates to a hypoglycemic tablet which is composed of pilose asiabell root, green tea, lilyturf root, tuckahoe, Chinese yam, shiitake fungus, white fungus, red sage root, haw, epimedium, licorice root, Chinese wolfberry and magnesium stearate. After hyphae of the hericium are cultured by the implantation in the patent of No. ZL88100118. X, medicine powder and medicine liquid are respectively made, mixed and processed into tablets. The hypoglycemic tablet made by the adoption of the compatibility of medicine and the production technology can increase the bioactivity and the medicine titer of dietotherapy Chinese herbal medicine; an immunological regulation function and an aging delaying function are combined to integrate the functions of a plurality of dietetic therapy ingredients of the Chinese herbal medicine; the prevention and cure effect on frequent pathogenesis of persons in the middle age and the old age is improved; the side effect of the hypoglycemic medicine is eliminated; if taken for a long time, the hypoglycemic tablet is favorable for the prevention and the cure of diabetes and the rehabilitation of patients with recessive diabetes.

Description

Metformin and production technology thereof

A kind of metformin relates to traditional Chinese herbal medicine and combines the health food that produces with biotechnology.

Middle-aged and elderly people fails because of immunologic function, the organ aging, add the infection of environmental pollution and viral pathogenic bacteria, and diet is unreasonable or life style science not, cause flu, asthma, emphysema, heart disease, diabetes or tumor etc. easily, threaten for middle old man's health, still do not have a kind of food of tool multi-function health-care at present, can regulate the physiological function of middle-aged and elderly people comprehensively.

Purpose of the present invention, be to provide a kind of health food, middle-aged and elderly people had the prevention and health care function, can eliminate the side effect of hypoglycemic medicine again, improve middle-aged and elderly people immunologic function, resisting fatigue and hypoxia-bearing capability, regulate blood sugar for human body, blood fat, thereby reach the purpose of slow down aging degree, regulate and improve the physiological function of middle-aged and elderly people.

The said metformin of the present invention, by Radix Codonopsis, green tea, Radix Ophiopogonis, Poria, mountain Chinese herbaceous peony, Lentinus Edodes and Tremella compositing formula A, with its culture medium as the said Hericium erinaceus (Bull. Ex Fr.) Pers. of ZL88100118.X patent, the concentrated medicament that the prescription B that the Rhizoma Dioscoreae of remaining part, Radix Salviae Miltiorrhizae, Fructus Crataegi, Herba Epimedii, Radix Glycyrrhizae, Fructus Lycii are formed is extracted, being mixed with the said magnesium stearate of prescription C is dried to into tablet and forms again.

The production technology of the said metformin of the present invention is:

1, takes by weighing Radix Codonopsis 11%, green tea 9%, Radix Ophiopogonis 8%, Rhizoma Dioscoreae 7%, Poria 7%, Lentinus Edodes 4%, Tremella 4% compositing formula A by full dose weight ratio, pulverize after selecting mixing respectively, after adding is mixed thoroughly by weight 1: 1 drinking water, to place sterilizing pan as culture medium in the 0.07 kilogram every bottle glass wide mouthed bottle of packing into, be 121 ℃ of high temperature sterilizes 2 hours in temperature.After the cooling, in the aseptic inoculation chamber, insert the described hedgehog hydnum strain of ZL88100118.X patent, placing temperature is 22～27 ℃. temperature is 65～70% biological engineering cultivation workshop, after leaving standstill 20～25 days, take out culture medium and mycelia, be cut into fragment, it is standby to make medicated powder with vacuum desiccator after temperature is 70 ℃ of following drying and crushing;

2, claim to choose Rhizoma Dioscoreae 11% by full dose weight ratio, Radix Salviae Miltiorrhizae 11%, Fructus Crataegi 9%, after Herba Epimedii 8%, Radix Glycyrrhizae 4.8% and Fructus Lycii 6% select and clean, merge and put into the Chinese medicine extraction jar, add 5 times of pure water and decoct 2 hours, after pouring out medicinal liquid, 2.5 of twice former dose of adding times of pure water decoct 2 times repeatedly respectively again, be to pour out medicinal liquid after 1 hour at every turn, merge three medical filtrations and be placed in the concentration pan, concentrate the prescription standby medicinal liquid that B made in 1: 1 ratio of former dried herbs weight (surveying proportion at 60～80 ℃ of intermittent fever is 1: 1.2);

8, extracting full dose weight ratio is the medicated powder that 0.2% the prescription C magnesium stearate and the A that fills a prescription make, after placing the blender mixing to stir, the medicinal liquid that adding is made by prescription B is mixing graininess in the mixer-granulator automatically, and being dried to moisture content under 70 ℃ of temperature is ± 5%;

4, place automatic tableting press to be pressed into tablet being dried to the particulate material of moisture content, the packing warehouse-in ± 5%.

Below in conjunction with embodiment in detail prescription of the present invention and production process are described in detail.

The said metformin of the present invention is made up of 13 flavors such as herbaceous plant Radix Codonopsis, green tea, Radix Ophiopogonis, Rhizoma Dioscoreae, Poria, Lentinus Edodes, Tremella, Radix Salviae Miltiorrhizae, Fructus Crataegi, Herba Epimedii, Radix Glycyrrhizae, Fructus Lycii and the said Hericium erinaceus (Bull. Ex Fr.) Pers. of ZL88100118.X patent of dietetic therapy unification, according to " record and the various pharmacological research of Chinese pharmacopoeia and documents such as " pharmacognosy " prove:

Radix Codonopsis: the dry root of campanulaceae plant, mainly contain bioactive substances such as triterpenoid compound, Saponin, sterol, inulin, fructose, aminoacid, have effects such as antiinflammatory, analgesia, blood pressure lowering and raise immunity, but invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting;

Green tea: the leaf of plant of theaceae has promoting the production of body fluid to quench thirst, resisting fatigue, aid digestion, lowering blood-fat and reducing weight, slow down aging, prophylaxis of hypertension, coronary heart disease etc.;

Radix Ophiopogonis: the root piece of liliaceous plant, have YIN nourishing and the production of body fluid promoting, lung moistening clearing away heart-fire for tranquillization and blood sugar lowering promote effects such as microcirculation;

Rhizoma Dioscoreae: the dry rhizome of Dioscoreaceae plant, contain material such as seed amino acid surplus mannan, choline, Rhizoma Dioscoreae alkali, glycoprotein, the polyphenol oxidase and ten, can invigorating the spleen to arrest diarrhea, invigorating the lung and the kidney, be used for that insufficiency of the spleen chronic diarrhea, chronic enteritis, the deficiency of the lung are breathed with cough, chronic nephritis, diabetes;

Poria: porous strain fungus has promoting diuresis to eliminate damp pathogen, the effect of invigorating spleen and relieving mental stress and beauty treatment;

Lentinus Edodes: Basidiomycetes umbrella section fungus has immunomodulating, antiviral, infection, antitumor and functions of lowering blood-fat and reducing weight.

Tremella: Basidiomycetes Tremella Cordycepps fungus has nourishing YIN and moistening the lung, enhance immunity and blood fat reducing hypoglycemic activity;

Radix Salviae Miltiorrhizae: the dry root and rhizome of labiate mainly contains TANSHINONES, cryptotanshinone, loyal heart element, material such as vitamin E, cupreol, energy promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, tranquilizing by nourishing the heart, coronary artery dilator, blood flow increasing has the effect of blood pressure lowering blood sugar lowering;

Herba Epimedii: the dry aerial parts of Berberidaceae plant, mainly contain bioactive substances such as flavone compound icariine, epimedoside A, sterol, oleic acid, linoleic acid, has the enhancing coronary flow, reducing pressure and sugar, antiinflammatory and immunoregulation effect, the energy invigorating the liver and kidney, bone and muscle strengthening, smart, the wind-damp dispelling of supporing yang benefit;

Radix Glycyrrhizae: the leguminous plant rhizome has heat-clearing and toxic substances removing, eliminating phlegm and stopping cough, the effect of concocting all medicines;

Fructus Lycii: the dry mature fruit of plant of Solanaceae; mainly contain betanin, zeaxanthine, carotene, riboflavin, lycium barbarum polysaccharide and materials such as multivitamin, trace element; have nourishing the liver and kidney, replenishing vital essence to improve eyesight, enhance immunity, leukocyte increasing, reducing pressure and sugar, effects such as the liver protecting.

The said metformin of the present invention is achieved in that

1, at first, by the full medicine weight ratio said Radix Codonopsis 11kg among the A that claims to fill a prescription, green tea 9kg, Radix Ophiopogonis 8kg, Rhizoma Dioscoreae 7kg, Poria 7kg, Lentinus Edodes 4kg, Tremella 4kg is after selecting mixing meticulously and pulverizing, adding the 50kg drinking water mixes thoroughly, packing into the deal of every bottle of 0.07kg is placed in the sterilizing pan as culture medium in the wide mouthed bottle, is 121 ℃ of high temperature sterilizes 2 hours with temperature, take out cooling after, in the aseptic inoculation chamber, insert the described Hericium erinaceus (Bull. Ex Fr.) Pers. strain of ZL88100118.X patent, placing temperature is 22～27 ℃, the biological engineering of humidity 60～70% is cultivated in the workshop, leaves standstill to cultivate 20～25 days, and the culture medium raw material that will have the Hericium erinaceus (Bull. Ex Fr.) Pers. mycelia then takes out chopping and places in the vacuum drying, after 70 ℃ of cold drying, all pulverizing is standby for medicated powder with raw material to put into ultrafine crusher.

2, weigh up said Rhizoma Dioscoreae 11kg among the prescription B, Radix Salviae Miltiorrhizae 11kg, Fructus Crataegi 9kg by full medicine weight ratio again, Herba Epimedii 8kg, Fructus Lycii 6kg and Radix Glycyrrhizae 4.8kg after the selected washing, merge and put into the Chinese medicine extraction jar, add pure water 250kg and decoct 2 hours, after pouring out medicinal liquid, respectively add the 125kg pure water more at twice, still infusion was poured out medicinal liquid after 1 hour at every turn, the medicinal liquid of pouring out for three times merged to filter be placed in the concentration pan, the medicinal liquid that is concentrated into 50kg is standby.

3, after the prescription C dolomol of the medicated powder adding 0.2kg that A made filling a prescription carries out stirring and evenly mixing; add the prescription medicinal liquid that B made again and making granule in the mixer-granulator automatically; in temperature is that to be dried to moisture content under 70 ℃ be ± 5%, places automatic tableting press to make the bottling of plain sheet packing again.

Metformin is unlikely to get damp in order to make, and in actual fabrication, can also add the film coating program one, and made tablet is placed the film coating machine, after sub-bottle packaging warehouse-in again, wrap up the enteric thin film for plain sheet, to improve people's assimilation effect.

Adopted said part and the production technology of joining of the present invention, the metformin of making, both can improve the biological activity and the medicine of dietetic therapy Chinese herbal medicine tires, immunomodulating and deferring senility are combined, can improve the prevention effect of centering old man regular incidence to the multiple dietetic therapy composition comprehensive function of Chinese herbal medicine, eliminate the side effect of hypoglycemic medicine, diabetics and susceptible disease crowd there is hypoglycemic, anti-fatigue anoxia-tolerance, constitutional effect.Simultaneously owing in this product, do not add antiseptic, additive, therefore no sucrose be the complete organic no side effects food therapeutic health of All Pure Nature whole plant, can take for a long time.

Claims (3)

1, a kind of metformin, it is characterized in that by Radix Codonopsis 11%, green tea 9%, Radix Ophiopogonis 8%, Poria 7%, Rhizoma Dioscoreae 7%, Lentinus Edodes 4%, the prescription A that Tremella 4% is formed, add water and make culture medium, insert the hedgehog hydnum strain, in 22～27 ℃, cultivate after 20～25 days, dry, pulverize the medicated powder of gained, with by Rhizoma Dioscoreae 11%, Radix Salviae Miltiorrhizae 11%, Fructus Crataegi 9%, Herba Epimedii 8%, Fructus Lycii 6%, the water extraction of Radix Glycyrrhizae 4.8%, the concentrated medicament that is 1:1.2 at 60～80 ℃ of heat survey proportions is prescription C mixing for prescription B with by magnesium stearate 0.2%, granulate, dry, the tablet of tabletting gained.

2, a kind of production technology of metformin is characterized in that:

(1) takes by weighing Radix Codonopsis 11% in proportion, green tea 9%, Radix Ophiopogonis 8%, Rhizoma Dioscoreae 7%, Poria 7%, Lentinus Edodes 4%, Tremella 4% compositing formula A, pulverize after selecting mixing respectively, by the above 7 flavor weight of being got with after pouring drinking water at 1: 1 and mixing thoroughly, to make culture medium in the 0.07 kilogram every bottle glass wide mouthed bottle of packing into, place sterilizing pan 121 ℃ of high temperature sterilizes of temperature 2 hours, after taking out cooling, in the aseptic inoculation chamber, insert the Hericium erinaceus (Bull. Ex Fr.) Pers. strain, placing temperature is 22～27 ℃, humidity be 65～70% biological engineering cultivate leave standstill 20～25 days in the workshop after, take out culture medium and mycelia, be cut into fragment, it is standby to make medicated powder with vacuum desiccator after temperature is 70 ℃ of following drying and crushing;

(2) take by weighing Rhizoma Dioscoreae 11% in proportion, Radix Salviae Miltiorrhizae 11%, Fructus Crataegi 9%, Herba Epimedii 8%, after Radix Glycyrrhizae 4.8% and Fructus Lycii 6% compositing formula B select and clean, merge and put into the Chinese medicine extraction jar, 5 times of pure water that add above-mentioned 6 kinds of medical herbs weight decoct 2 hours, after pouring out medicinal liquid, 2.5 of twice former dose of adding times of pure water decoct 2 times repeatedly respectively again, be to pour out medicinal liquid after 1 hour at every turn, merge three medical filtrations and be placed in the concentration pan, in 1: 1 ratio of former dried herbs weight or to survey proportions at 60～80 ℃ of intermittent fever be 1: 1.2 ratio, it is standby to concentrate the prescription medicinal liquid that B made;

(3) last is the medicated powder that 0.2% the prescription C magnesium stearate and the A that fills a prescription make by full dose weight ratio again; after placing the blender mixing to stir; add the medicinal liquid that prescription B makes; automatically mixing graininess in the mixer-granulator; being dried to moisture content under 70 ℃ of temperature is ± 5%, places automatic tableting press to be pressed into tablet packing warehouse-in then.

3,, it is characterized in that placing made tablet the film coating machine to wrap up behind the enteric thin film sub-bottle packaging warehouse-in again according to the production technology of the said metformin of claim 2.