CN116726233A - Adhesive for gastric venous vascular embolism and preparation method thereof - Google Patents
Adhesive for gastric venous vascular embolism and preparation method thereof Download PDFInfo
- Publication number
- CN116726233A CN116726233A CN202310693940.2A CN202310693940A CN116726233A CN 116726233 A CN116726233 A CN 116726233A CN 202310693940 A CN202310693940 A CN 202310693940A CN 116726233 A CN116726233 A CN 116726233A
- Authority
- CN
- China
- Prior art keywords
- adhesive
- gastric
- alpha
- venous vascular
- vascular embolism
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000001070 adhesive effect Effects 0.000 title claims abstract description 53
- 239000000853 adhesive Substances 0.000 title claims abstract description 51
- 208000005189 Embolism Diseases 0.000 title claims abstract description 29
- 230000002792 vascular Effects 0.000 title claims abstract description 28
- 230000002496 gastric effect Effects 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title description 6
- 239000004014 plasticizer Substances 0.000 claims abstract description 23
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims abstract description 22
- 239000011230 binding agent Substances 0.000 claims description 18
- 239000003755 preservative agent Substances 0.000 claims description 13
- 230000002335 preservative effect Effects 0.000 claims description 13
- JJJFUHOGVZWXNQ-UHFFFAOYSA-N enbucrilate Chemical compound CCCCOC(=O)C(=C)C#N JJJFUHOGVZWXNQ-UHFFFAOYSA-N 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 12
- IJVRPNIWWODHHA-UHFFFAOYSA-N 2-cyanoprop-2-enoic acid Chemical compound OC(=O)C(=C)C#N IJVRPNIWWODHHA-UHFFFAOYSA-N 0.000 claims description 9
- RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 6
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims description 6
- 235000013769 triethyl citrate Nutrition 0.000 claims description 6
- 239000001069 triethyl citrate Substances 0.000 claims description 6
- JDEFPFLTCXIVDH-UHFFFAOYSA-N 2-cyanopropanoic acid Chemical compound N#CC(C)C(O)=O JDEFPFLTCXIVDH-UHFFFAOYSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 claims description 4
- -1 alpha-cyano propionate Chemical compound 0.000 claims description 3
- 230000010102 embolization Effects 0.000 claims description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 2
- ZIICMERUPGNFJK-UHFFFAOYSA-N benzoic acid butan-1-ol Chemical compound C(C1=CC=CC=C1)(=O)O.C(CCC)O ZIICMERUPGNFJK-UHFFFAOYSA-N 0.000 claims description 2
- RPQUGMLCZLGZTG-UHFFFAOYSA-N octyl cyanoacrylate Chemical compound CCCCCCCCOC(=O)C(=C)C#N RPQUGMLCZLGZTG-UHFFFAOYSA-N 0.000 claims description 2
- 235000010241 potassium sorbate Nutrition 0.000 claims description 2
- 239000004302 potassium sorbate Substances 0.000 claims description 2
- 229940069338 potassium sorbate Drugs 0.000 claims description 2
- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 claims description 2
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 abstract description 3
- 230000004054 inflammatory process Effects 0.000 abstract description 3
- 238000007789 sealing Methods 0.000 abstract description 3
- 238000007711 solidification Methods 0.000 abstract description 3
- 230000008023 solidification Effects 0.000 abstract description 3
- 239000004830 Super Glue Substances 0.000 abstract description 2
- 239000002313 adhesive film Substances 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- FGBJXOREULPLGL-UHFFFAOYSA-N ethyl cyanoacrylate Chemical compound CCOC(=O)C(=C)C#N FGBJXOREULPLGL-UHFFFAOYSA-N 0.000 abstract description 2
- 230000002439 hemostatic effect Effects 0.000 abstract description 2
- 230000035807 sensation Effects 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 9
- 229950010048 enbucrilate Drugs 0.000 description 8
- 229920001651 Cyanoacrylate Polymers 0.000 description 7
- 208000027418 Wounds and injury Diseases 0.000 description 6
- 239000003292 glue Substances 0.000 description 5
- 230000006378 damage Effects 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 239000002893 slag Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- MWCLLHOVUTZFKS-UHFFFAOYSA-N Methyl cyanoacrylate Chemical compound COC(=O)C(=C)C#N MWCLLHOVUTZFKS-UHFFFAOYSA-N 0.000 description 1
- 208000031737 Tissue Adhesions Diseases 0.000 description 1
- 206010046274 Upper gastrointestinal haemorrhage Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0021—Plasticisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses an adhesive for gastric venous embolism, which is gel at least comprising 18-25wt% of citrate plasticizer, the prepared cyanoacrylate adhesive is soft, the adhesive film formed after solidification does not generate foreign body sensation, the adhesive block is prevented from generating friction with human tissues to cause inflammatory reaction, the adhesive has good biocompatibility and excellent adhesive property, has better hemostatic sealing effect on vascular embolism, and can meet clinical treatment requirements.
Description
Technical Field
The invention relates to the field of biomedical materials, in particular to the field of I PC A61, and more particularly relates to an adhesive for gastric venous vascular embolism and a preparation method thereof.
Background
The biomedical adhesive can replace surgical suture lines in the clinical operation process, is favorable for better sealing and biological tissue adhesion, and can be widely applied to repairing treatment of gastrointestinal tracts, viscera, cardiovascular and epidermal mucous membranes and the like. When the embolism treatment of the gastric vein blood vessel is carried out, the medical adhesive can be used for acting on the wound of the upper gastrointestinal hemorrhage by puncture treatment, so that the wound is quickly solidified to block the blood vessel, thereby blocking the blood flow and achieving the function of embolism hemostasis.
CN114796591a discloses a cyanoacrylate medical glue, which adopts medical glue matrix, comonomer and thickener, and the prepared medical glue has moderate polymerization time, and the cured product has excellent adhesion property and hardness when used for vascular embolism application, and the comonomer and single binder component are used, so that the adhesion time can be shortened, but the formed glue layer has larger brittleness and insufficient adhesion strength.
Disclosure of Invention
In order to solve the above problems, a first aspect of the present invention provides an adhesive for gastric venous vascular embolism, which is a gel comprising at least 18-25wt% of citrate plasticizer.
Preferably, the gel further comprises a binder and a preservative.
Preferably, the mass ratio of the binder to the citrate plasticizer is (2.5-3.8): 1.
Preferably, the mass ratio of the binder to the citrate plasticizer is 3.5:1.
Preferably, the citrate plasticizer is at least one of acetyl triethyl citrate and triethyl citrate.
Preferably, the citrate plasticizer is triethyl citrate.
Preferably, the binder is at least one of an alpha-cyano propionate binder and a fibrin binder.
Preferably, the binder is an alpha-cyanopropionate binder.
Preferably, the alpha-cyanopropionate adhesive is at least one of alpha-n-butyl cyanoacrylate, alpha-n-butyl cyanoacrylate and alpha-n-octyl cyanoacrylate.
Preferably, the alpha-cyanopropionate binder is n-butyl alpha-cyanoacrylate.
Preferably, the preservative is at least one of butanol benzoic acid, anisole and potassium sorbate.
Preferably, the preservative is anisole.
A second aspect of the present invention provides a method for preparing an adhesive for gastric venous vascular embolism as described above, comprising at least the steps of:
(1) Preparing a mixture of poly alpha-cyanoacrylate and a citrate plasticizer;
(2) And (3) mixing the mixture prepared in the step (1) with a binder and a preservative uniformly and stirring the mixture to obtain the adhesive.
Preferably, the step (1) specifically includes: and mixing and stirring the alpha-cyanoacrylate and the citrate plasticizer uniformly, and then performing ultrasonic irradiation to obtain a mixture of the poly alpha-cyanoacrylate and the citrate plasticizer.
Preferably, the irradiation illuminance is 200-400W/cm 2 The irradiation time is 25-45 min.
Preferably, the irradiation illuminance is 300W/cm 2 The irradiation time was 30mi n.
The invention prepares poly alpha-n-butyl cyanoacrylate by ultrasonic irradiation of alpha-n-butyl cyanoacrylate, and the irradiation condition is controlled to be 300W/cm 2 The irradiation time is 30mi < n >, the polydispersity and the stereoregularity of the generated poly-alpha-n-butyl cyanoacrylate are improved, the poly-alpha-n-butyl cyanoacrylate is more soluble in triethyl citrate and the poly-alpha-n-butyl cyanoacrylate, the adhesive strength of the adhesive prepared by taking the alpha-n-butyl cyanoacrylate and the poly-alpha-n-butyl cyanoacrylate as two adhesive components is high, the ectopic embolism caused by the entering of glue block and slag into blood can not be generated, the use safety and the stability are improved, and meanwhile, hard blocks can not be generated during the use, so that the inflammatory reaction caused by the damage to human tissues is avoided, and the use safety and the use comfort of patients are ensured.
The beneficial effects are that:
1. the invention provides an adhesive for gastric venous vascular embolism and a preparation method thereof, which can be rapidly solidified when in operation, realize rapid hemostasis, and have high bonding strength after solidification without producing slag or secondary injury caused by falling off.
2. According to the invention, the poly-alpha-n-butyl cyanoacrylate is synthesized by irradiating the alpha-n-butyl cyanoacrylate, so that the operation is simple and convenient, the reaction is rapid, and the generated poly-alpha-n-butyl cyanoacrylate and the alpha-n-butyl cyanoacrylate can be rapidly dissolved in triethyl citrate.
3. According to the invention, the poly alpha-n-butyl cyanoacrylate and the alpha-n-butyl cyanoacrylate are prepared and compounded to be used as the adhesive, so that the compatibility of the poly alpha-n-butyl cyanoacrylate and the alpha-n-butyl cyanoacrylate can be improved, and the bonding strength of the prepared adhesive is improved.
4. The cyanoacrylate adhesive prepared by the invention has soft adhesive film formed after solidification, does not generate foreign body feeling on human body, and prevents inflammatory reaction caused by friction between the adhesive block and human tissue.
5. The adhesive prepared by the invention has good biocompatibility and excellent adhesive property, has good hemostatic and sealing effects on vascular embolism, and can meet clinical treatment requirements.
Detailed Description
Examples
Example 1:
example 1 provides an adhesive for gastric venous vascular embolization which is a gel comprising 22% by weight of a citrate plasticizer, 77.97% of a binder, 0.03% of a preservative.
The citrate plasticizer is triethyl citrate.
The binder was n-butyl alpha-cyanoacrylate, purchased from Beijing Fu Erle technology development Co.
The preservative is anisole.
The preparation method of the adhesive for gastric venous vascular embolism comprises the following steps:
(1) Preparing a mixture of poly alpha-cyanoacrylate and a citrate plasticizer;
(2) And (3) mixing the mixture prepared in the step (1) with a binder and a preservative uniformly and stirring the mixture to obtain the adhesive.
The step (1) comprises the following steps: and mixing and stirring the alpha-cyanoacrylate and the citrate plasticizer uniformly, and then performing ultrasonic irradiation to obtain a mixture of the poly alpha-cyanoacrylate and the citrate plasticizer.
The irradiation sound intensity is 300W/cm 2 The irradiation time was 30mi n.
Example 2
Example 2 provides an adhesive for gastric venous vascular embolization, which is specific to example 1, except that the adhesive is a gel comprising 28.6wt% citrate plasticizer, 71.37% binder, 0.03% preservative.
Comparative example 1
Comparative example 1 provides an adhesive for gastric venous vascular embolism, the specific embodiment of which is the same as example 1, except that the preparation method of the adhesive for gastric venous vascular embolism is as follows: mixing the adhesive and the plasticizer, heating at 120 ℃ for 30 min, adding the preservative, uniformly stirring, and cooling to 25 ℃.
Comparative example 2
Comparative example 2 provides an adhesive for gastric venous vascular embolism, the specific embodiment of which is the same as example 1, except that the adhesive is a gel comprising 12wt% of citrate plasticizer, 87.97% of binder, and 0.03% of preservative.
Performance test:
1. peel strength: the peel strength of the adhesives for gastric venous vascular embolism prepared in examples 1-2 and comparative examples 1-2 of the present invention was measured, the test standard was YY/T0729.2-2009, and the test results are reported in table 1;
2. wound closure strength: the wound closure strength of the adhesives for gastric venous vascular embolism prepared in examples 1-2 and comparative examples 1-2 of the present invention was measured, the test standard was YY/T0729.4-2009, and the test results are reported in table 1;
3. tensile strength: the tensile strength of the adhesives for gastric venous vascular embolism prepared in examples 1-2 and comparative examples 1-2 of the present invention was measured, the test standard was YY/T0729.3-2009, and the test results are reported in table 1;
TABLE 1
| T-peel strength | Wound closure Strength | Tensile Strength | |
| Example 1 | 3.01 | 48.3 | 0.32 |
| Example 2 | 2.95 | 48.1 | 0.30 |
| Comparative example 1 | 2.03 | 42.2 | 0.23 |
| Comparative example 2 | 1.95 | 41.7 | 0.24 |
Claims (10)
1. An adhesive for gastric venous vascular embolism, which is characterized in that the adhesive is gel at least comprising 18-25wt% of citrate plasticizer.
2. The adhesive for gastric venous vascular embolism according to claim 1, characterized in that the gel further comprises a binder and a preservative.
3. The adhesive for gastric venous vascular embolism according to claim 2, characterized in that the mass ratio of the adhesive to the citrate plasticizer is (2.5-3.8): 1.
4. The adhesive for gastric venous vascular embolism according to claim 1, wherein the citrate plasticizer is at least one of acetyl triethyl citrate and triethyl citrate.
5. The adhesive for gastric venous vascular embolism according to claim 2, characterized in that the adhesive is at least one of an alpha-cyano propionate adhesive, a fibrin adhesive.
6. The adhesive for gastric venous vascular embolism of claim 5 wherein the adhesive is an alpha-cyano propionate adhesive.
7. The adhesive for gastric venous vascular embolism of claim 6 wherein the alpha-cyanopropionate adhesive is at least one of alpha-n-butyl cyanoacrylate, alpha-n-octyl cyanoacrylate.
8. The adhesive for gastric venous vascular embolism of claim 2, wherein the preservative is at least one of butanol benzoic acid, anisole, potassium sorbate.
9. A method for preparing an adhesive for gastric venous vascular embolization according to any one of claims 6-8, comprising at least the following steps:
(1) Preparing a mixture of poly alpha-cyanoacrylate and a citrate plasticizer;
(2) And (3) mixing the mixture prepared in the step (1) with a binder and a preservative uniformly and stirring the mixture to obtain the adhesive.
10. The method for preparing an adhesive for gastric venous vascular embolism according to claim 9, wherein the step (1) is specifically: and mixing and stirring the alpha-cyanoacrylate and the citrate plasticizer uniformly, and then performing ultrasonic irradiation to obtain a mixture of the poly alpha-cyanoacrylate and the citrate plasticizer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310693940.2A CN116726233A (en) | 2023-06-13 | 2023-06-13 | Adhesive for gastric venous vascular embolism and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310693940.2A CN116726233A (en) | 2023-06-13 | 2023-06-13 | Adhesive for gastric venous vascular embolism and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116726233A true CN116726233A (en) | 2023-09-12 |
Family
ID=87918052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310693940.2A Pending CN116726233A (en) | 2023-06-13 | 2023-06-13 | Adhesive for gastric venous vascular embolism and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116726233A (en) |
-
2023
- 2023-06-13 CN CN202310693940.2A patent/CN116726233A/en active Pending
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