CN116712502A - External bone-knitting plaster and preparation method thereof - Google Patents
External bone-knitting plaster and preparation method thereof Download PDFInfo
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- CN116712502A CN116712502A CN202310844059.8A CN202310844059A CN116712502A CN 116712502 A CN116712502 A CN 116712502A CN 202310844059 A CN202310844059 A CN 202310844059A CN 116712502 A CN116712502 A CN 116712502A
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The application discloses an external bone-knitting plaster and a preparation method thereof, wherein the external bone-knitting plaster comprises the following components in parts by weight: 65-75 parts of ground beetle, 65-75 parts of dragon bone, 65-75 parts of eucommia bark, 65-75 parts of drynaria rhizome, 65-75 parts of Chinese angelica, 65-75 parts of safflower, 65-75 parts of szechuan lovage rhizome, 45-55 parts of pearl garden balsam stem, 25-35 parts of frankincense, 25-35 parts of myrrh, 45-55 parts of suberect spatholobus stem, 25-35 parts of cortex toosendan, 25-35 parts of mugwort leaf, 65-75 parts of prepared rehmannia root, 65-75 parts of red paeony root, 45-55 parts of costustoot, 45-55 parts of dragon's blood, 25-35 parts of crinis carbonium, 15-25 parts of borneol and 1-3 parts of artificial musk. The external bone-knitting plaster disclosed by the application has the advantages of good curative effect, quick response, small toxic and side effects, difficult allergy after long-term application, obvious detumescence effect on early and middle stages of fracture, and effective promotion of local metabolism of injury and repair of fracture wounds.
Description
Technical Field
The application relates to the technical field of traditional Chinese medicines, in particular to an external bone-knitting plaster and a preparation method thereof.
Background
Fracture is a common disease and frequently-occurring disease of trauma surgery, and is characterized by severe illness and severe injury, such as life-long disability and even life danger caused by no timely treatment or improper treatment. The traditional fracture treatment method is to use the external plaster for treatment after reduction, and the performance of the external plaster directly influences the fracture treatment effect and the economic burden of patients. It can be seen that the external bone-knitting plaster with good development efficacy, short treatment course and low side effect has very important effects on relieving the pain and economic burden of fracture patients.
The existing external bone-knitting plaster has the defects of long treatment course, single curative effect, long-term taking, damage to liver and kidney functions, even influence on bone growth, slow effect taking, long treatment period and difficult lasting use of patients, so that the ideal treatment effect cannot be achieved. For example, the Chinese patent document CN109793850A discloses an external bone-knitting plaster and a preparation method thereof, wherein the plaster main material consists of pseudo-ginseng, red sage root, drynaria rhizome, teasel root, agilawood, lycopodium clavatum, cortex acanthopanacis, hairy antler, goat tibia, goat bone marrow, deer tendon, herba Aristolochiae Mollissimae, ground beetle, chinese starjasmine stem, radix clematidis, safflower, scorpion, agilawood, native copper, musk, catechu, dragon's blood, frankincense and medicated leaven, and the plaster is in the form of an external plaster. The external bone-knitting plaster and the preparation method thereof have obvious curative effect on bone knitting, the patient with severe fracture can walk out of bed in a short time, the patient with comminuted fracture can be restored to the state of normal people after using the traditional Chinese medicine plaster, the traditional Chinese medicine plaster has no toxic or side effect, the cost is low, the cure rate of the fracture is greatly improved after clinical experiments, the effect is very obvious, and great convenience is brought to the patient. However, the efficacy and onset of action of the product still remain to be further improved.
Therefore, a more proper process and formula are sought, the prepared external bone-knitting plaster has good curative effect, quick response, small toxic and side effects, difficult allergy after long-term application, obvious detumescence effect on early and middle stages of fracture, and can effectively promote the metabolism of local injury and the repair of fracture wounds, meets the market demand, has wide market value and application prospect, and has very important significance for promoting the further development of the external bone-knitting plaster.
Disclosure of Invention
The application mainly aims to provide the external bone-knitting plaster which has good curative effect, quick response, small toxic and side effects, is not easy to be allergic after long-term application, has obvious detumescence effect on early and middle stages of fracture, and can effectively promote local metabolism of injury and repair of fracture wounds and a preparation method thereof.
In order to achieve the above purpose, the application adopts the following technical scheme: an external bone-knitting plaster comprises the following components in parts by weight: 65-75 parts of ground beetle, 65-75 parts of dragon bone, 65-75 parts of eucommia bark, 65-75 parts of drynaria rhizome, 65-75 parts of Chinese angelica, 65-75 parts of safflower, 65-75 parts of szechuan lovage rhizome, 45-55 parts of pearl garden balsam stem, 25-35 parts of frankincense, 25-35 parts of myrrh, 45-55 parts of suberect spatholobus stem, 25-35 parts of cortex toosendan, 25-35 parts of mugwort leaf, 65-75 parts of prepared rehmannia root, 65-75 parts of red paeony root, 45-55 parts of costustoot, 45-55 parts of dragon's blood, 25-35 parts of crinis carbonium, 15-25 parts of borneol and 1-3 parts of artificial musk.
Preferably, the preparation components of the external bone-knitting plaster further comprise: 10-16 parts of peach kernel, 8-12 parts of catechu, 15-25 parts of teasel root, 25-35 parts of mistletoe, 30-40 parts of erythrina bark, 25-35 parts of pericarpium zanthoxyli, 8-12 parts of radix clematidis, 45-55 parts of radix sileris and 8-12 parts of liquorice.
Preferably, the preparation components of the external bone-knitting plaster further comprise: 8-12 parts of glabrous sarcandra herb, 10-16 parts of cortex schizophragmatis integrifolii radicis, 5-8 parts of euonymus alatus, 8-12 parts of erigeron breviscapus, 25-35 parts of cassia twig and radix codonopsis, 6-10 parts of motherwort and 20-30 parts of radix polygoni multiflori.
Preferably, the preparation components of the external bone-knitting plaster further comprise: 2-6 parts of carbon quantum dots, 3-6 parts of nano negative ion powder, 1-3 parts of germanite powder and 1-3 parts of far infrared ceramic powder.
Preferably, the external bone-knitting plaster comprises the following components in parts by weight: 70 parts of ground beetle, 70 parts of dragon bone, 70 parts of eucommia bark, 70 parts of drynaria rhizome, 70 parts of Chinese angelica, 70 parts of safflower, 70 parts of szechuan lovage rhizome, 50 parts of pearl garden balsam stem, 30 parts of frankincense, 30 parts of myrrh, 50 parts of suberect spatholobus stem, 30 parts of cortex toosendan, 30 parts of mugwort leaf, 70 parts of prepared rehmannia root, 70 parts of red paeony root, 50 parts of costustoot, 50 parts of dragon's blood, 30 parts of carbonized hair, 20 parts of borneol, 2 parts of artificial musk, 13 parts of peach seed, 10 parts of catechu, 20 parts of himalayan teasel root, 30 parts of Chinese taxillus twig, 35 parts of erythrina bark, 30 parts of pericarpium zanthoxyli, 10 parts of clematis root, 50 parts of divaricate saposhnikovia root, 10 parts of liquorice, 10 parts of glabrous sarcandra herb, 13 parts of cortex schizophragmatis integrifolia, 6.5 parts of common cold herb, 10 parts of common jasminoxidil herb, 30 parts of Chinese angelica root, 4 parts of carbon quantum dots, 4 parts of nano negative ion powder, 2 parts of germanica powder, and 2 parts of far infrared ceramic powder.
Preferably, the carbon quantum dots are graphene quantum dots.
Preferably, the particle size of the nano negative ion powder is 10-80nm.
Preferably, the particle size of the germanite powder is 600-1200 meshes; the particle size of the far infrared ceramic powder is 800-1200 meshes.
The application also provides a preparation method of the external bone-knitting plaster, which comprises the following steps: frying Eupolyphaga Seu Steleophaga and edible vegetable oil in a pot, removing residues, filtering, and refining into drop beads to obtain medicinal oil; slowly pouring yellow lead after the medicinal oil boils, continuously stirring in the clockwise direction, when the smoke is not emitted in the pot any more and the mixture in the pot is in a black oil paste form, dipping the ointment in the pot with bamboo chopsticks, dripping cold water, forming the ointment on the water surface into beads, taking the beads out, wiping the surface water, kneading with a dry hand, stopping fire if the beads are stuck to the hands and are not greasy when leaving the hands, and continuously stirring until the ointment is cooled to normal temperature after stopping fire; soaking the ointment in cold water for three days with water changed 2 times a day; then taking out the soaked ointment, air drying, melting again in a hot pot, grinding other components, sieving with 500-800 mesh sieve, spreading into the pot, mixing with melted ointment, collecting ointment with bamboo chopstick, and spreading on non-woven fabric or cloth.
Preferably, the mass ratio of the ground beetles to the edible vegetable oil is 1 (28-35).
Preferably, the mass ratio of the yellow lead to the edible vegetable oil is (15-21): 48.
Due to the application of the technical scheme, compared with the prior art, the application has the following advantages:
(1) The preparation method of the external bone-knitting plaster provided by the application can be realized by adopting conventional equipment and technology, has the advantages of low energy consumption, less investment, simple technology, convenient operation, low equipment dependence and short preparation period, is suitable for industrial production, and has higher popularization and application values.
(2) The application provides an external bone-knitting plaster which comprises the following components in parts by weight: 65-75 parts of ground beetle, 65-75 parts of dragon bone, 65-75 parts of eucommia bark, 65-75 parts of drynaria rhizome, 65-75 parts of Chinese angelica, 65-75 parts of safflower, 65-75 parts of szechuan lovage rhizome, 45-55 parts of pearl garden balsam stem, 25-35 parts of frankincense, 25-35 parts of myrrh, 45-55 parts of suberect spatholobus stem, 25-35 parts of cortex toosendan, 25-35 parts of mugwort leaf, 65-75 parts of prepared rehmannia root, 65-75 parts of red paeony root, 45-55 parts of costustoot, 45-55 parts of dragon's blood, 25-35 parts of crinis carbonium, 15-25 parts of borneol and 1-3 parts of artificial musk. Through reasonable selection of components and formulas, the components and the formulas can better play a synergistic effect, and under the mutual cooperation of the components and the formulas, the prepared ointment has good curative effect, quick response, small toxic and side effects, is not easy to be allergic after being applied for a long time, has obvious detumescence effect on early and middle stages of fracture, and can effectively promote local metabolism of injury and repair of fracture wounds.
(3) The application provides an external bone-knitting plaster, which further comprises: 10-16 parts of peach kernel, 8-12 parts of catechu, 15-25 parts of teasel root, 25-35 parts of mistletoe, 30-40 parts of erythrina bark, 25-35 parts of pericarpium zanthoxyli, 8-12 parts of radix clematidis, 45-55 parts of radix sileris, 8-12 parts of liquorice, 8-12 parts of herba sarcandrae, 10-16 parts of cortex schizophragmatis integrifolii radicis, 5-8 parts of euonymus alatus, 8-12 parts of common rush, 25-35 parts of cassia pilose asiabell root, 6-10 parts of motherwort herb and 20-30 parts of radix polygoni multiflori; the plaster is matched with other components, so that the prepared plaster has obvious curative effect on bone fracture, a patient with severe fracture can walk out of bed in a short time, the patient with comminuted fracture can be recovered to a normal state after using the traditional Chinese medicine plaster, the plaster has no toxic or side effect, the cost is low, the cure rate of the fracture is greatly improved after clinical experiments, the effect is very obvious, and great convenience is brought to the patient; the components have synergistic effect, so that the product has the effects of continuous connection of bones and muscles, blood circulation promoting, blood stasis removing, swelling and pain relieving, and decay removing and tissue regeneration promoting; can be used for treating traumatic injury and fracture, promoting porosis, and eliminating local swelling and pain.
(4) The application provides an external bone-knitting plaster, which further comprises: 2-6 parts of carbon quantum dots, 3-6 parts of nano negative ion powder, 1-3 parts of germanite powder and 1-3 parts of far infrared ceramic powder; by adding the components, the plaster has the health care function, can provide microenvironment beneficial to recovery for the fracture, further realize rapid detumescence, avoid allergy after long-term application, and promote local metabolism of injury and repair of fracture wounds.
Detailed Description
The following description is presented to enable one of ordinary skill in the art to make and use the application. The preferred embodiments in the following description are by way of example only and other obvious variations will occur to those skilled in the art.
Example 1
An external bone-knitting plaster comprises the following components in parts by weight: 65 parts of ground beetle, 65 parts of dragon bone, 65 parts of eucommia bark, 65 parts of drynaria rhizome, 65 parts of Chinese angelica, 65 parts of safflower, 65 parts of szechuan lovage rhizome, 45 parts of pearl garden balsam stem, 25 parts of frankincense, 25 parts of myrrh, 45 parts of suberect spatholobus stem, 25 parts of cortex toonae sinensis Radicis, 25 parts of mugwort leaf, 65 parts of prepared rehmannia root, 65 parts of red paeony root, 45 parts of costustoot, 45 parts of dragon's blood, 25 parts of carbonized hair, 15 parts of borneol and 1 part of artificial musk.
The preparation components of the external bone-knitting plaster also comprise: 10 parts of peach kernel, 8 parts of catechu, 15 parts of teasel root, 25 parts of mistletoe, 30 parts of erythrina bark, 25 parts of pericarpium zanthoxyli, 8 parts of radix clematidis, 45 parts of radix sileris and 8 parts of liquorice.
The preparation components of the external bone-knitting plaster also comprise: 8 parts of glabrous sarcandra herb, 10 parts of cortex schizophragmatis integrifolii radicis, 5 parts of Euonymus alatus, 8 parts of Lantern rush herb, 25 parts of cassia codonopsis pilosula, 6 parts of motherwort herb and 20 parts of chinaroot greenbrier rhizome.
The preparation components of the external bone-knitting plaster also comprise: 2 parts of carbon quantum dots, 3 parts of nano negative ion powder, 1 part of germanite powder and 1 part of far infrared ceramic powder.
The carbon quantum dots are graphene quantum dots; the particle size of the nano negative ion powder is 10nm; the particle size of the germanite powder is 600 meshes; the particle size of the far infrared ceramic powder is 800 meshes.
The preparation method of the external bone-knitting plaster comprises the following steps: frying Eupolyphaga Seu Steleophaga and edible vegetable oil in a pot, removing residues, filtering, and refining into drop beads to obtain medicinal oil; slowly pouring yellow lead after the medicinal oil boils, continuously stirring in the clockwise direction, when the smoke is not emitted in the pot any more and the mixture in the pot is in a black oil paste form, dipping the ointment in the pot with bamboo chopsticks, dripping cold water, forming the ointment on the water surface into beads, taking the beads out, wiping the surface water, kneading with a dry hand, stopping fire if the beads are stuck to the hands and are not greasy when leaving the hands, and continuously stirring until the ointment is cooled to normal temperature after stopping fire; soaking the ointment in cold water for three days with water changed 2 times a day; then taking out the soaked ointment, airing, putting into a hot pot for remelting, grinding other components, sieving with a 500-mesh sieve, scattering into the pot, uniformly mixing with the melted ointment, taking the ointment out by using bamboo chopstick balls, and spreading on non-woven fabrics or cloth to obtain the ointment; the mass ratio of the ground beeltle to the edible vegetable oil is 1:28; the mass ratio of the yellow lead to the edible vegetable oil is 15:48.
Example 2
An external bone-knitting plaster comprises the following components in parts by weight: 68 parts of ground beetle, 68 parts of dragon bone, 68 parts of eucommia bark, 68 parts of drynaria rhizome, 68 parts of Chinese angelica, 68 parts of safflower, 68 parts of szechuan lovage rhizome, 48 parts of pearl garden balsam stem, 28 parts of frankincense, 28 parts of myrrh, 48 parts of suberect spatholobus stem, 28 parts of Chinese toona bark, 28 parts of mugwort leaf, 68 parts of prepared rehmannia root, 68 parts of red paeony root, 48 parts of costustoot, 48 parts of dragon's blood, 28 parts of carbonized hair, 18 parts of borneol and 1.5 parts of artificial musk.
The preparation components of the external bone-knitting plaster also comprise: 12 parts of peach kernel, 9 parts of catechu, 16 parts of teasel root, 27 parts of mistletoe, 33 parts of erythrina bark, 27 parts of pericarpium zanthoxyli, 9 parts of radix clematidis, 47 parts of radix sileris and 9 parts of liquorice.
The preparation components of the external bone-knitting plaster also comprise: 9 parts of glabrous sarcandra herb, 12 parts of glabrous sarcandra herb, 6 parts of euonymus alatus, 9 parts of common rush herb, 27 parts of cassia twig and pilose asiabell root, 7 parts of motherwort herb and 23 parts of chinaroot greenbrier rhizome.
The preparation components of the external bone-knitting plaster also comprise: 3 parts of carbon quantum dots, 4 parts of nano negative ion powder, 1.5 parts of germanite powder and 1.5 parts of far infrared ceramic powder.
The carbon quantum dots are graphene quantum dots; the particle size of the nano negative ion powder is 30nm; the particle size of the germanite powder is 800 meshes; the particle size of the far infrared ceramic powder is 900 meshes.
The preparation method of the external bone-knitting plaster comprises the following steps: frying Eupolyphaga Seu Steleophaga and edible vegetable oil in a pot, removing residues, filtering, and refining into drop beads to obtain medicinal oil; slowly pouring yellow lead after the medicinal oil boils, continuously stirring in the clockwise direction, when the smoke is not emitted in the pot any more and the mixture in the pot is in a black oil paste form, dipping the ointment in the pot with bamboo chopsticks, dripping cold water, forming the ointment on the water surface into beads, taking the beads out, wiping the surface water, kneading with a dry hand, stopping fire if the beads are stuck to the hands and are not greasy when leaving the hands, and continuously stirring until the ointment is cooled to normal temperature after stopping fire; soaking the ointment in cold water for three days with water changed 2 times a day; then taking out the soaked ointment, airing, putting into a hot pot for remelting, grinding other components, sieving with a 600-mesh sieve, scattering into the pot, uniformly mixing with the melted ointment, taking the ointment out by using bamboo chopstick balls, and spreading on non-woven fabrics or cloth to obtain the ointment; the mass ratio of the ground beeltle to the edible vegetable oil is 1:30; the mass ratio of the yellow lead to the edible vegetable oil is 18:48.
Example 3
An external bone-knitting plaster comprises the following components in parts by weight: 70 parts of ground beetle, 70 parts of dragon bone, 70 parts of eucommia bark, 70 parts of drynaria rhizome, 70 parts of Chinese angelica, 70 parts of safflower, 70 parts of szechuan lovage rhizome, 50 parts of pearl garden balsam stem, 30 parts of frankincense, 30 parts of myrrh, 50 parts of suberect spatholobus stem, 30 parts of cortex toosendan, 30 parts of mugwort leaf, 70 parts of prepared rehmannia root, 70 parts of red paeony root, 50 parts of costustoot, 50 parts of dragon's blood, 30 parts of carbonized hair, 20 parts of borneol, 2 parts of artificial musk, 13 parts of peach seed, 10 parts of catechu, 20 parts of himalayan teasel root, 30 parts of Chinese taxillus twig, 35 parts of erythrina bark, 30 parts of pericarpium zanthoxyli, 10 parts of clematis root, 50 parts of divaricate saposhnikovia root, 10 parts of liquorice, 10 parts of glabrous sarcandra herb, 13 parts of cortex schizophragmatis integrifolia, 6.5 parts of common cold herb, 10 parts of common jasminoxidil herb, 30 parts of Chinese angelica root, 4 parts of carbon quantum dots, 4 parts of nano negative ion powder, 2 parts of germanica powder, and 2 parts of far infrared ceramic powder.
The carbon quantum dots are graphene quantum dots; the particle size of the nano negative ion powder is 60nm; the particle size of the germanite powder is 900 meshes; the particle size of the far infrared ceramic powder is 1000 meshes.
The preparation method of the external bone-knitting plaster comprises the following steps: frying Eupolyphaga Seu Steleophaga and edible vegetable oil in a pot, removing residues, filtering, and refining into drop beads to obtain medicinal oil; slowly pouring yellow lead after the medicinal oil boils, continuously stirring in the clockwise direction, when the smoke is not emitted in the pot any more and the mixture in the pot is in a black oil paste form, dipping the ointment in the pot with bamboo chopsticks, dripping cold water, forming the ointment on the water surface into beads, taking the beads out, wiping the surface water, kneading with a dry hand, stopping fire if the beads are stuck to the hands and are not greasy when leaving the hands, and continuously stirring until the ointment is cooled to normal temperature after stopping fire; soaking the ointment in cold water for three days with water changed 2 times a day; then taking out the soaked ointment, airing, putting into a hot pot for remelting, grinding other components, sieving with a 650-mesh sieve, scattering into the pot, uniformly mixing with the melted ointment, taking the ointment out by using bamboo chopstick balls, and spreading on non-woven fabrics or cloth to obtain the ointment; the mass ratio of the ground beeltle to the edible vegetable oil is 1:32; the mass ratio of the yellow lead to the edible vegetable oil is 18:48.
Example 4
An external bone-knitting plaster comprises the following components in parts by weight: 73 parts of ground beetle, 73 parts of dragon bone, 73 parts of eucommia ulmoides, 73 parts of drynaria rhizome, 73 parts of Chinese angelica, 73 parts of safflower, 74 parts of szechuan lovage rhizome, 53 parts of pearl garden balsam stem, 33 parts of frankincense, 33 parts of myrrh, 53 parts of suberect spatholobus stem, 33 parts of cortex toosendan, 32 parts of mugwort leaf, 73 parts of prepared rehmannia root, 72 parts of red paeony root, 53 parts of costustoot, 53 parts of dragon's blood, 32 parts of carbonized hair, 22 parts of borneol and 2.5 parts of artificial musk.
The preparation components of the external bone-knitting plaster also comprise: 15 parts of peach kernel, 11 parts of catechu, 23 parts of teasel root, 33 parts of mistletoe, 38 parts of erythrina bark, 33 parts of pericarpium zanthoxyli, 11 parts of radix clematidis, 53 parts of radix sileris and 11 parts of liquorice.
The preparation components of the external bone-knitting plaster also comprise: 11 parts of glabrous sarcandra herb, 15 parts of glabrous sarcandra herb, 7.5 parts of garden balsam stem, 11 parts of common rush herb, 33 parts of cassia codonopsis pilosula, 9.5 parts of motherwort herb and 28 parts of climbing tiger.
The preparation components of the external bone-knitting plaster also comprise: 5.5 parts of carbon quantum dots, 5.5 parts of nano negative ion powder, 2.5 parts of germanite powder and 2.5 parts of far infrared ceramic powder.
The carbon quantum dots are graphene quantum dots; the particle size of the nano negative ion powder is 70nm; the particle size of the germanite powder is 1100 meshes; the particle size of the far infrared ceramic powder is 1100 meshes.
The preparation method of the external bone-knitting plaster comprises the following steps: frying Eupolyphaga Seu Steleophaga and edible vegetable oil in a pot, removing residues, filtering, and refining into drop beads to obtain medicinal oil; slowly pouring yellow lead after the medicinal oil boils, continuously stirring in the clockwise direction, when the smoke is not emitted in the pot any more and the mixture in the pot is in a black oil paste form, dipping the ointment in the pot with bamboo chopsticks, dripping cold water, forming the ointment on the water surface into beads, taking the beads out, wiping the surface water, kneading with a dry hand, stopping fire if the beads are stuck to the hands and are not greasy when leaving the hands, and continuously stirring until the ointment is cooled to normal temperature after stopping fire; soaking the ointment in cold water for three days with water changed 2 times a day; then taking out the soaked ointment, airing, putting into a hot pot for remelting, grinding other components, sieving with a 750-mesh sieve, scattering into the pot, uniformly mixing with the melted ointment, taking the ointment out by using bamboo chopstick balls, and spreading on non-woven fabrics or cloth to obtain the ointment; the mass ratio of the ground beeltle to the edible vegetable oil is 1:33; the mass ratio of the yellow lead to the edible vegetable oil is 20:48.
Example 5
An external bone-knitting plaster comprises the following components in parts by weight: 75 parts of ground beetle, 75 parts of dragon bone, 75 parts of eucommia ulmoides, 75 parts of drynaria rhizome, 75 parts of Chinese angelica, 75 parts of safflower, 75 parts of szechuan lovage rhizome, 55 parts of pearl garden balsam stem, 35 parts of frankincense, 35 parts of myrrh, 55 parts of suberect spatholobus stem, 35 parts of cortex toonae sinensis Radicis, 35 parts of mugwort leaf, 75 parts of prepared rehmannia root, 75 parts of red paeony root, 55 parts of costustoot, 55 parts of dragon's blood, 35 parts of carbonized hair, 25 parts of borneol and 3 parts of artificial musk.
The preparation components of the external bone-knitting plaster also comprise: 16 parts of peach kernel, 12 parts of catechu, 25 parts of teasel root, 35 parts of mistletoe, 40 parts of erythrina bark, 35 parts of pericarpium zanthoxyli, 12 parts of radix clematidis, 55 parts of radix sileris and 12 parts of liquorice.
The preparation components of the external bone-knitting plaster also comprise: 12 parts of glabrous sarcandra herb, 16 parts of cortex schizophragmatis integrifolii radicis, 8 parts of euonymus alatus, 12 parts of common rush, 35 parts of cassia codonopsis pilosula, 10 parts of motherwort herb and 30 parts of chinaroot greenbrier rhizome.
The preparation components of the external bone-knitting plaster also comprise: 6 parts of carbon quantum dots, 6 parts of nano negative ion powder, 3 parts of germanite powder and 3 parts of far infrared ceramic powder.
The carbon quantum dots are graphene quantum dots; the particle size of the nano negative ion powder is 80nm; the particle size of the germanite powder is 1200 meshes; the particle size of the far infrared ceramic powder is 1200 meshes.
The preparation method of the external bone-knitting plaster comprises the following steps: frying Eupolyphaga Seu Steleophaga and edible vegetable oil in a pot, removing residues, filtering, and refining into drop beads to obtain medicinal oil; slowly pouring yellow lead after the medicinal oil boils, continuously stirring in the clockwise direction, when the smoke is not emitted in the pot any more and the mixture in the pot is in a black oil paste form, dipping the ointment in the pot with bamboo chopsticks, dripping cold water, forming the ointment on the water surface into beads, taking the beads out, wiping the surface water, kneading with a dry hand, stopping fire if the beads are stuck to the hands and are not greasy when leaving the hands, and continuously stirring until the ointment is cooled to normal temperature after stopping fire; soaking the ointment in cold water for three days with water changed 2 times a day; then taking out the soaked ointment, airing, putting into a hot pot for remelting, grinding other components, sieving with a 800-mesh sieve, scattering into the pot, uniformly mixing with the melted ointment, taking the ointment out by using bamboo chopstick balls, and spreading on non-woven fabrics or cloth to obtain the ointment; the mass ratio of the ground beeltle to the edible vegetable oil is 1:35; the mass ratio of the yellow lead to the edible vegetable oil is 21:48.
Comparative example 1
This example provides an external bone-knitting plaster which is substantially the same as in example 1, except that no carbon quantum dots, cassia-pilose asiabell root and pericarpium zanthoxyli are added.
Comparative example 2
This example provides an external bone-knitting plaster which is substantially the same as in example 1, except that germanite powder, osseous wind and cortex toonae sinensis Radicis are not added.
Comparative example 3
This example provides an external bone-knitting plaster, which is prepared by the method of example 1 in patent document CN 109793850A.
The external bone-knitting plaster obtained in the above examples 1 to 5 and comparative examples 1 to 3 were subjected to the relevant performance test, the test results are shown in Table 1, and the test method is as follows:
efficacy assessment criteria:
semi-quantitative criteria for symptoms and signs
| Symptoms and signs | Normal state | Mild and mild | Moderate degree | Heavy weight | |
| 1 | Pain and pain | Pain-free | Light pain and tolerance | Heavy pain and no influence on sleeping | Persistent and uncomfortable effects on sleep |
| 2 | Swelling of the skin | No swelling | Light swelling and soft touch | Obvious swelling and harder touch | Severe swelling and hard touch |
| 3 | Skin ecchymosis | No skin ecchymosis | Light color, small area less than 5cm 2 | Deep color and 5-10cm large area 2 | Deep color, wide area of more than 10cm 2 |
Typical clinical case enrollment criteria:
inclusion criteria: has typical clinical manifestations without the incorporation of other diseases.
1. Patient with traumatic injury; 2. the ages are between 5 and 60 years.
Reject criteria: 1. open fracture or complications thereof; 2. pathological fractures due to bone diseases (benign or malignant tumors, tuberculosis, osteomyelitis, endocrine metabolism, etc.); 3. women in gestation or lactation period, allergic to the drug; 4. critical illness state, and is difficult to evaluate the effectiveness and safety of the observed medicines; 5. the ages are under 5 years old or over 60 years old.
Each group of 20 patients were randomly selected, and the external bone-knitting plaster of examples 1-5 and comparative examples 1-2 were applied 1 time a day, 1 treatment course was 2 weeks, the amount of each treatment was 20g, the total disappearance of symptoms after one treatment course was significant, the significant improvement was effective, and the symptoms were ineffective without any change. The number of people who were effective, significant and ineffective in each group was counted separately.
TABLE 1
As can be seen from Table 1, the external bone-knitting plaster of each example of the present application has better efficacy, which is the result of the synergistic effect of each component, and the addition of carbon quantum dots, cassia pilosula, pericarpium zanthoxyli, germanite powder, radix seu cortex toosendan, and cortex toonae sinensis Radicis is beneficial for improving the above properties.
The foregoing has shown and described the basic principles, principal features and advantages of the application. It will be understood by those skilled in the art that the present application is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present application, and various changes and modifications may be made therein without departing from the spirit and scope of the application, which is defined by the appended claims. The scope of the application is defined by the appended claims and equivalents thereof.
Claims (10)
1. The external bone-knitting plaster is characterized by comprising the following components in parts by weight: 65-75 parts of ground beetle, 65-75 parts of dragon bone, 65-75 parts of eucommia bark, 65-75 parts of drynaria rhizome, 65-75 parts of Chinese angelica, 65-75 parts of safflower, 65-75 parts of szechuan lovage rhizome, 45-55 parts of pearl garden balsam stem, 25-35 parts of frankincense, 25-35 parts of myrrh, 45-55 parts of suberect spatholobus stem, 25-35 parts of cortex toosendan, 25-35 parts of mugwort leaf, 65-75 parts of prepared rehmannia root, 65-75 parts of red paeony root, 45-55 parts of costustoot, 45-55 parts of dragon's blood, 25-35 parts of crinis carbonium, 15-25 parts of borneol and 1-3 parts of artificial musk.
2. The external bone-knitting plaster of claim 1, wherein the preparation components of the external bone-knitting plaster further comprise: 10-16 parts of peach kernel, 8-12 parts of catechu, 15-25 parts of teasel root, 25-35 parts of mistletoe, 30-40 parts of erythrina bark, 25-35 parts of pericarpium zanthoxyli, 8-12 parts of radix clematidis, 45-55 parts of radix sileris and 8-12 parts of liquorice.
3. The external bone-knitting plaster of claim 1, wherein the preparation components of the external bone-knitting plaster further comprise: 8-12 parts of glabrous sarcandra herb, 10-16 parts of cortex schizophragmatis integrifolii radicis, 5-8 parts of euonymus alatus, 8-12 parts of erigeron breviscapus, 25-35 parts of cassia twig and radix codonopsis, 6-10 parts of motherwort and 20-30 parts of radix polygoni multiflori.
4. The external bone-knitting plaster of claim 1, wherein the preparation components of the external bone-knitting plaster further comprise: 2-6 parts of carbon quantum dots, 3-6 parts of nano negative ion powder, 1-3 parts of germanite powder and 1-3 parts of far infrared ceramic powder.
5. The external bone-knitting plaster as claimed in claim 4, wherein the external bone-knitting plaster is prepared from the following components in parts by weight: 70 parts of ground beetle, 70 parts of dragon bone, 70 parts of eucommia bark, 70 parts of drynaria rhizome, 70 parts of Chinese angelica, 70 parts of safflower, 70 parts of szechuan lovage rhizome, 50 parts of pearl garden balsam stem, 30 parts of frankincense, 30 parts of myrrh, 50 parts of suberect spatholobus stem, 30 parts of cortex toosendan, 30 parts of mugwort leaf, 70 parts of prepared rehmannia root, 70 parts of red paeony root, 50 parts of costustoot, 50 parts of dragon's blood, 30 parts of carbonized hair, 20 parts of borneol, 2 parts of artificial musk, 13 parts of peach seed, 10 parts of catechu, 20 parts of himalayan teasel root, 30 parts of Chinese taxillus twig, 35 parts of erythrina bark, 30 parts of pericarpium zanthoxyli, 10 parts of clematis root, 50 parts of divaricate saposhnikovia root, 10 parts of liquorice, 10 parts of glabrous sarcandra herb, 13 parts of cortex schizophragmatis integrifolia, 6.5 parts of common cold herb, 10 parts of common jasminoxidil herb, 30 parts of Chinese angelica root, 4 parts of carbon quantum dots, 4 parts of nano negative ion powder, 2 parts of germanica powder, and 2 parts of far infrared ceramic powder.
6. The external bone fracture plaster of claim 4, wherein the carbon quantum dots are graphene quantum dots; the particle size of the nano negative ion powder is 10-80nm.
7. The external bone fracture plaster according to claim 4, wherein the germanite powder has a particle size of 600-1200 mesh; the particle size of the far infrared ceramic powder is 800-1200 meshes.
8. A method of preparing a topical bone-knitting plaster according to any one of claims 1-7, comprising the steps of: frying Eupolyphaga Seu Steleophaga and edible vegetable oil in a pot, removing residues, filtering, and refining into drop beads to obtain medicinal oil; slowly pouring yellow lead after the medicinal oil boils, continuously stirring in the clockwise direction, when the smoke is not emitted in the pot any more and the mixture in the pot is in a black oil paste form, dipping the ointment in the pot with bamboo chopsticks, dripping cold water, forming the ointment on the water surface into beads, taking the beads out, wiping the surface water, kneading with a dry hand, stopping fire if the beads are stuck to the hands and are not greasy when leaving the hands, and continuously stirring until the ointment is cooled to normal temperature after stopping fire; soaking the ointment in cold water for three days with water changed 2 times a day; then taking out the soaked ointment, air drying, melting again in a hot pot, grinding other components, sieving with 500-800 mesh sieve, spreading into the pot, mixing with melted ointment, collecting ointment with bamboo chopstick, and spreading on non-woven fabric or cloth.
9. The method for preparing the external bone-knitting plaster according to claim 8, wherein the mass ratio of the ground beetle to the edible vegetable oil is 1 (28-35).
10. The method for preparing a bone-knitting plaster for external use according to claim 8, wherein the mass ratio of the yellow lead to the edible vegetable oil is (15-21): 48.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202310844059.8A CN116712502A (en) | 2023-07-11 | 2023-07-11 | External bone-knitting plaster and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310844059.8A CN116712502A (en) | 2023-07-11 | 2023-07-11 | External bone-knitting plaster and preparation method thereof |
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