CN116705375A - Isotope production solid-liquid coupling target device based on accelerator - Google Patents
Isotope production solid-liquid coupling target device based on accelerator Download PDFInfo
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- CN116705375A CN116705375A CN202310274417.6A CN202310274417A CN116705375A CN 116705375 A CN116705375 A CN 116705375A CN 202310274417 A CN202310274417 A CN 202310274417A CN 116705375 A CN116705375 A CN 116705375A
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 93
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- 238000010168 coupling process Methods 0.000 title abstract description 13
- 238000005859 coupling reaction Methods 0.000 title abstract description 13
- 239000007787 solid Substances 0.000 claims description 87
- 238000006243 chemical reaction Methods 0.000 claims description 38
- 239000000463 material Substances 0.000 claims description 19
- 229910052770 Uranium Inorganic materials 0.000 claims description 15
- JFALSRSLKYAFGM-UHFFFAOYSA-N uranium(0) Chemical compound [U] JFALSRSLKYAFGM-UHFFFAOYSA-N 0.000 claims description 15
- 230000005540 biological transmission Effects 0.000 claims description 14
- 239000002826 coolant Substances 0.000 claims description 10
- 229910000384 uranyl sulfate Inorganic materials 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 9
- 229910001152 Bi alloy Inorganic materials 0.000 claims description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
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- 229910002804 graphite Inorganic materials 0.000 claims description 6
- 239000010439 graphite Substances 0.000 claims description 6
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- 229920000573 polyethylene Polymers 0.000 claims description 6
- QSGNKXDSTRDWKA-UHFFFAOYSA-N zirconium dihydride Chemical compound [ZrH2] QSGNKXDSTRDWKA-UHFFFAOYSA-N 0.000 claims description 6
- 229910000568 zirconium hydride Inorganic materials 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 4
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- 238000003745 diagnosis Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- NMFHJNAPXOMSRX-PUPDPRJKSA-N [(1r)-3-(3,4-dimethoxyphenyl)-1-[3-(2-morpholin-4-ylethoxy)phenyl]propyl] (2s)-1-[(2s)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate Chemical compound C([C@@H](OC(=O)[C@@H]1CCCCN1C(=O)[C@@H](CC)C=1C=C(OC)C(OC)=C(OC)C=1)C=1C=C(OCCN2CCOCC2)C=CC=1)CC1=CC=C(OC)C(OC)=C1 NMFHJNAPXOMSRX-PUPDPRJKSA-N 0.000 description 2
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- 238000006467 substitution reaction Methods 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- FUJCRWPEOMXPAD-UHFFFAOYSA-N Li2O Inorganic materials [Li+].[Li+].[O-2] FUJCRWPEOMXPAD-UHFFFAOYSA-N 0.000 description 1
- 206010056677 Nerve degeneration Diseases 0.000 description 1
- LTPBRCUWZOMYOC-UHFFFAOYSA-N beryllium oxide Inorganic materials O=[Be] LTPBRCUWZOMYOC-UHFFFAOYSA-N 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
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- XUCJHNOBJLKZNU-UHFFFAOYSA-M dilithium;hydroxide Chemical compound [Li+].[Li+].[OH-] XUCJHNOBJLKZNU-UHFFFAOYSA-M 0.000 description 1
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- 238000001727 in vivo Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 229910052745 lead Inorganic materials 0.000 description 1
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- 229910002007 uranyl nitrate Inorganic materials 0.000 description 1
Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E30/00—Energy generation of nuclear origin
- Y02E30/10—Nuclear fusion reactors
Abstract
The invention relates to the technical field of isotope production, in particular to an accelerator-based isotope production solid-liquid coupling target device, which aims to solve the problems of low yield and low production efficiency of isotopes produced by an accelerator and high production cost. For this purpose, the accelerator-based isotope production solid-liquid coupled target device of the present invention comprises: an accelerator, a shield, and an isotope production assembly; the accelerator is used for generating proton beam; the shielding body is provided with a proton beam channel and an inner cavity which are communicated and used for entering proton beam; the isotope production assembly is arranged in the inner cavity and is used for producing isotopes for a plurality of times. The solid-liquid coupling target device for isotope production based on the accelerator comprises the accelerator, the shielding body and the isotope production assembly, wherein the isotope production assembly can be used for producing isotopes repeatedly, so that the production efficiency is improved, the isotope production yield is improved, and the production cost is further saved.
Description
Technical Field
The invention relates to the technical field of isotope production, and particularly provides an accelerator-based solid-liquid coupling target device for isotope production.
Background
The medical isotope medicament is the key of important medical diagnosis and treatment, such as Tc-99m, lu-177, ge-68, Y-90 and other medical isotopes, can be prepared into medicaments for in vivo diagnosis medicaments, in vitro diagnosis medicaments, radioactive medicaments for treatment and the like, and has irreplaceable advantages in the fields of diagnosis and treatment of serious diseases such as cardiovascular and cerebrovascular diseases, malignant tumors, nerve degeneration and the like.
At present, an accelerator is used for isotope production, but generally, the yield of the isotope produced by the accelerator is low, the production efficiency is low, and the production cost is high.
Accordingly, there is a need in the art for a new accelerator-based isotope production solid-liquid coupled target apparatus that addresses the above-described issues.
Disclosure of Invention
The invention aims to solve the technical problems that the production yield of isotopes is low, the production efficiency is low and the production cost is high in the existing accelerator.
The invention provides an accelerator-based isotope production solid-liquid coupled target device, which comprises an accelerator, a shielding body and an isotope production assembly, wherein the shielding body is arranged on the accelerator; the accelerator is used for generating proton beam; the shielding body is provided with a proton beam channel and an inner cavity which are communicated and used for the proton beam to enter; the isotope production assembly is arranged in the inner cavity so that the proton beam irradiates and is used for producing isotopes for multiple times.
Under the condition that the technical scheme is adopted, the solid-liquid coupling target device for isotope production based on the accelerator comprises the accelerator, the shielding body and the isotope production assembly, the proton beam is generated through the accelerator, enters a proton beam channel of the shielding body, irradiates the isotope production assembly, and can produce isotopes repeatedly, so that the isotope production yield is improved, and further the production cost is saved.
In the preferred technical scheme of the accelerator-based isotope production solid-liquid coupled target device, the isotope production assembly comprises a first solid target piece, a first liquid target, a first multiplication layer, a first slowing layer and a second liquid target; the first solid target piece is arranged in the inner cavity and props against the proton beam flow channel so that the proton beam irradiation generates first neutrons; the first liquid target is arranged in the inner cavity and adjacent to the first solid target piece and is used for generating reaction with the first neutrons so as to produce isotopes and second neutrons; the first multiplication layer is arranged in the inner cavity and adjacent to the first liquid target and is used for carrying out multiplication reaction on the second neutrons; the first moderating layer is arranged in the inner cavity and adjacent to the first multiplying layer and is used for moderating the second neutrons after the multiplication reaction; the second liquid target is disposed in the inner cavity and adjacent to the first moderating layer for reacting with the second neutrons to produce isotopes and third neutrons.
Under the condition that the technical scheme is adopted, the solid-liquid coupling target device for isotope production based on the accelerator disclosed by the invention is used for producing first neutrons by irradiating the first solid target piece through proton beam, the first neutrons and the first liquid target are utilized to produce reaction to produce isotopes and second neutrons, the second neutrons and the first multiplication layer are utilized to produce reaction to increase the quantity of the second neutrons, and the first moderation layer is used for producing isotopes and third neutrons by reacting the increased quantity of the second neutrons, so that the isotope production yield is improved.
In the preferred technical scheme of the accelerator-based isotope production solid-liquid coupled target device, the isotope production assembly further comprises a second multiplication layer, a second slowing layer and a third liquid target; the second multiplication layer is arranged in the inner cavity and adjacent to the second liquid target and is used for carrying out multiplication reaction on the third neutrons; the second moderating layer is arranged in the inner cavity and adjacent to the second multiplying layer and is used for moderating the third neutrons after the multiplication reaction; the third liquid target is disposed in the inner cavity and adjacent to the second moderating layer for reacting with the third neutrons to produce isotopes and fourth neutrons.
Under the condition of adopting the technical scheme, the solid-liquid coupling target device for isotope production based on the accelerator carries out multiplication reaction on third neutrons through the second multiplication layer so as to increase the yield of the third neutrons, and the second moderation layer carries out reaction on the increased number of the third neutrons to produce isotopes and fourth neutrons, so that the isotope production yield is further improved.
In a preferred technical solution of the accelerator-based isotope production solid-liquid coupled target device, the isotope production assembly further includes a second solid target piece; the second solid target is disposed in the inner cavity and adjacent to the third liquid target for reacting with the fourth neutrons to produce isotopes.
Under the condition of adopting the technical scheme, the solid-liquid coupling target device for isotope production based on the accelerator, disclosed by the invention, can produce isotopes through the reaction of the second solid target piece and the fourth neutron, and further improves the isotope production yield.
In the preferred technical scheme of the accelerator-based isotope production solid-liquid coupled target device, the device further comprises a circulating system, wherein the circulating system comprises a liquid target transmission system, a heat exchange system and a driving pump; the driving pump is respectively connected with the first liquid target, the second liquid target and the third liquid target and is used for driving and converging the first liquid target, the second liquid target and the third liquid target to form an integral liquid target; the heat exchange system is connected with the driving pump and is used for cooling the integral liquid target; the liquid target transmission system is connected with the heat exchange system, so that the cooled integral liquid target enters the inner cavity of the shielding body to form a new first liquid target, a new second liquid target and a new third liquid target.
Under the condition of adopting the technical scheme, the solid-liquid coupling target device for isotope production based on the accelerator drives and gathers the first liquid target, the second liquid target and the third liquid target to form an integral liquid target through the driving pump, and the integral liquid target is cooled through the heat exchange treatment of the heat exchange system, and the cooled integral liquid target is shunted by the liquid target conveying system to form a new first liquid target, a new second liquid target and a new third liquid target, so that the solid-liquid coupling target device is convenient to reuse and can save cost.
In the preferred technical scheme of the solid-liquid coupled target device for accelerator-based isotope production, the circulating system further comprises an isotope extraction system; the isotope extraction system is connected with the heat exchange system and is used for extracting isotopes in the integral liquid target.
Under the condition of adopting the technical scheme, the solid-liquid coupling target device for isotope production based on the accelerator is convenient for the later use of isotopes by extracting isotopes through an isotope extraction system.
In a preferred embodiment of the above-described accelerator-based isotope production solid-liquid coupled target apparatus, the heat exchange system has a coolant inlet and a coolant outlet.
Under the condition of adopting the technical scheme, the solid-liquid coupling target device for isotope production based on the accelerator is used for cooling the heat exchange system through the coolant inlet and the coolant outlet, so that the heat exchange system is maintained within a set temperature.
In a preferred technical scheme of the accelerator-based isotope production solid-liquid coupled target device, the device further comprises a first solid target transmission system; the first solid target transmission system extends in the inner cavity of the shielding body and is connected with the first solid target piece for replacing the first solid target piece.
Under the condition of adopting the technical scheme, the first target piece can be replaced on line by arranging the first solid target transmission system, so that the method is convenient and quick.
In a preferred technical scheme of the accelerator-based isotope production solid-liquid coupled target device, the device further comprises a second solid target transmission system; the second solid target transmission system extends in the inner cavity of the shielding body and is connected with the second solid target piece for replacing the second solid target piece.
Under the condition of adopting the technical scheme, the second target piece can be replaced on line by arranging the second solid target transmission system, so that convenience and rapidness are realized.
In the preferred technical scheme of the solid-liquid coupled target device for producing isotopes based on the accelerator, the material of the first solid target piece is any one of BeO, be, li2O, li; the first liquid target, the second liquid target and the third liquid target are made of uranyl sulfate solution or other uranium-containing solutions; the materials of the first multiplication layer and the second multiplication layer are any one of Be, beO, pb, bi, pbO, pb-Bi alloy; the first and second slowing layers are made of any one of graphite, zirconium hydride and polyethylene; the second solid target is any one of N-14, co-59, Y-89 and Lu-176.
Drawings
Preferred embodiments of the present invention are described below with reference to the accompanying drawings, in which:
fig. 1 is a side cross-sectional view of an accelerator-based isotope production solid-liquid coupled target apparatus of the present invention.
Marking list in the figure:
1. a shield; 11. proton beam channels;
2. an isotope production assembly; 21. a first solid state target; 22. a first liquid target; 23. a first multiplication layer; 24. a first moderating layer; 25. a second liquid target; 26. a second multiplication layer; 27. a second moderating layer; 28. a third liquid target; 29. a second solid state target;
3. a first multiplication layer; 31. a liquid target delivery system; 32. a heat exchange system; 33. an isotope extraction system; 321. a coolant inlet; 322. a coolant outlet;
4. a first solid target delivery system;
5. a second solid target delivery system.
Detailed Description
Preferred embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood by those skilled in the art that these embodiments are merely for explaining the technical principle of the accelerator-based isotope production solid-liquid coupled target apparatus of the present invention, and are not intended to limit the scope of the present invention.
It should be noted that in the description of the present invention, furthermore, the terms "first," "second," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
Furthermore, it should be noted that, in the description of the present invention, unless explicitly specified and limited otherwise, the terms "disposed," "connected" and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be directly connected, can be indirectly connected through an intermediate medium, and can also be communicated with the inside of two elements. The specific meaning of the above terms in the present invention can be understood by those skilled in the art according to the specific circumstances.
Referring first to fig. 1, the present invention provides an accelerator-based isotope production solid-liquid coupled target apparatus generally comprising an accelerator (not shown), a shield 1, and an isotope production assembly 2. Wherein the accelerator is used for generating proton beam, the shielding body 1 is provided with a proton beam channel 11 and an inner cavity (not marked in the figure) which are communicated, and is used for entering the proton beam, and the isotope production assembly 2 is arranged in the inner cavity, so that the proton beam irradiates and is used for producing isotopes for a plurality of times. The accelerator is used for generating a proton beam, the proton beam enters the proton beam channel 11 of the shielding body 1, the isotope production assembly 2 is irradiated, and the isotope production assembly 2 can produce isotopes repeatedly, so that the isotope production yield is improved, and the production cost is further saved.
With continued reference to fig. 1, the shielding body 1 is generally a column, and is not limited to a column, but may be other shapes such as a rectangular body, etc. The shielding body 1 has a housing, a filler material is injected into the housing, an inlet end of a proton beam passage 11 of the shielding body 1 is arranged corresponding to the accelerator, and a cross-sectional shape of the proton beam passage 11 is generally circular or rectangular.
Referring to fig. 1, in one embodiment, an isotope production assembly 2 generally includes a first solid target piece 21, a first liquid target 22, a first multiplication layer 23, a first slowing layer 24, and a second liquid target 25. The first solid target 21 is disposed in the inner cavity and abuts against the proton beam channel 11, so that the proton beam irradiates to generate first neutrons. A first liquid target 22 is disposed within the interior cavity adjacent to the first solid target 21 for reacting with the first neutrons to produce isotopes and second neutrons. The first multiplication layer 23 is disposed in the inner cavity and adjacent to the first liquid target 22, and is used for carrying out multiplication reaction on the second neutrons, the first slowing-down layer 24 is disposed in the inner cavity and adjacent to the first multiplication layer 23, and is used for carrying out slowing-down treatment on the second neutrons after the multiplication reaction, and the second liquid target 25 is disposed in the inner cavity and adjacent to the first slowing-down layer 24, and is used for carrying out reaction with the second neutrons to produce isotopes and third neutrons. The first solid target 21 is irradiated by the proton beam to produce first neutrons, and the first neutrons and the first liquid target 22 are utilized to react to produce isotopes and second neutrons, the second neutrons and the first multiplication layer 23 are reacted to increase the number of the second neutrons, and the first moderation layer 24 reacts the increased number of the second neutrons to produce isotopes and third neutrons, so that isotope production is realized for a plurality of times to improve isotope production yield.
In this embodiment, the material of the first solid target 21 is any one of BeO, be, li2O, li, the material of the first liquid target 22 and the second liquid target 25 are uranyl sulfate solution or other uranium-containing solutions, the material of the first multiplication layer 23 is any one of Be, beO, pb, bi, pbO, pb-Bi alloy, and the material of the first slowing layer 24 is any one of graphite, zirconium hydride and polyethylene.
With continued reference to fig. 1, in this embodiment, the first solid target 21 is a generally disc or rectangular sheet, and the first liquid target 22 is stored in a first gap (not labeled in the drawing) between the first solid target 21 and the first multiplication layer 23, and the first multiplication layer 23 can generate (n, 2 n) or (n, 3 n) reactions to effectively increase the number of neutrons so as to increase the yield of group isotopes. The first moderating layer 24 is used to slow down the neutron energy by moderating the multiplied neutrons. A second liquid target 25 is stored in a second gap (not shown) between the first moderating layer 24 and the second multiplying layer 26.
Referring to fig. 1, in one embodiment, the isotope production assembly 2 further includes a second multiplication layer 26, a second slowing layer 27, and a third liquid target 28. Wherein a second multiplication layer 26 is disposed in the interior cavity and adjacent to the second liquid target 25 for multiplying the third neutrons. The second moderating layer 27 is disposed in the inner cavity and adjacent to the second multiplying layer 26, and is used for moderating the third neutrons after the multiplication reaction. A third liquid target 28 is disposed within the interior cavity adjacent to the second moderating layer 27 for reacting with the third neutrons to produce isotopes and fourth neutrons. The third neutrons are subjected to multiplication reaction through the second multiplication layer 26 to increase the third neutron yield, and the second moderation layer 26 reacts the increased number of third neutrons to produce isotopes and fourth neutrons, thereby further increasing the isotope production yield.
In this embodiment, the second multiplication layer 26 is made of any one of Be, beO, pb, bi, pbO, pb-Bi alloy, the second slowing layer 27 is made of any one of graphite, zirconium hydride and polyethylene, and the first solid target 21 is made of any one of BeO, be, li2O, li.
With continued reference to fig. 1, in this embodiment, a third liquid target 28 is stored in a third gap (not shown) between the second moderating layer 27 and the second solid target 29, and the second multiplication layer 26 may generate (n, 2 n) or (n, 3 n) reactions effective to increase the number of neutrons in order to increase the production of group isotopes. The second moderating layer 27 is used to slow down the neutron energy by moderating the multiplied neutrons. Isotopes are produced by the second solid state target 28 and fourth neutron production reactions, and isotope production yields are still further improved.
Referring to fig. 1, in one embodiment, the isotope production assembly 2 further includes a second solid target 29. Wherein a second solid target 29 is disposed within the interior chamber adjacent to the third liquid target 28 for reacting with a fourth neutron to produce an isotope. The second solid state target 29 is shaped identically, typically as a wafer or rectangular piece, and the second solid state target 29 and the first solid state target 21 remain identical in shape.
With continued reference to fig. 1, in one embodiment, the overall shape of the first solid state target 21, the first liquid state target 22, the first multiplication layer 23, the first slowing layer 24, the second liquid state target 25, the second multiplication layer 26, the second slowing layer 27, the third liquid state target 28, and the second solid state target 29 are substantially identical, and are neat in construction to facilitate the respective functions. And the first solid target 21, the first liquid target 22, the first multiplication layer 23, the first slowing layer 24, the second liquid target 25, the second multiplication layer 26, the second slowing layer 27, the third liquid target 28 and the second solid target 29 are substantially identical in height and width, and neat in structure.
Referring to fig. 1, in one embodiment, the accelerator-based isotope production solid-liquid coupled target apparatus of the present invention further comprises a circulation system 3, the circulation system 3 generally comprising a liquid target delivery system 31, a heat exchange system 32, and a drive pump 33. The driving pump 33 is respectively connected with the first liquid target 22, the second liquid target 25 and the third liquid target 28, and is used for driving and converging the first liquid target 22, the second liquid target 25 and the third liquid target 28 into a whole liquid target. The heat exchange system 32 is connected with a driving pump 33 for cooling the whole liquid target. The liquid target transmission system 31 is connected with the heat exchange system 32, so that the cooled integral liquid target enters the inner cavity of the shielding body 1 to form a new first liquid target, a new second liquid target and a new third liquid target, thereby being convenient for reuse and saving the cost.
Wherein the heat exchange system 32 has a coolant inlet 321 and a coolant outlet 322.
It should be noted that, the liquid target delivery system 31, the heat exchange system 32 and the driving pump 33 are all existing, and specific structures are not described herein.
With continued reference to fig. 1, in this embodiment, the driving pump 33 is respectively connected to the first gap containing the first liquid target 22 through three pipes, the second gap containing the second liquid target 25 is connected to the third gap containing the third liquid target 28, and is used for driving the first liquid target 22, the second liquid target 25 and the third liquid target 28 to be assembled into an integral liquid target, and the driving pump 33 is further connected to the heat exchange system 32 through the pipes, and is used for exchanging heat with the integral liquid target to reduce the temperature. The liquid target conveying system 31 is connected with the heat exchange system 32 through a pipeline so that the cooled integral liquid target enters the liquid target conveying system 31, and the liquid target conveying system 31 is communicated with the first gap, the second gap and the third gap through three other pipelines respectively, so that the cooled integral liquid target enters the first gap, the second gap and the third gap to form a new first liquid target, a new second liquid target and a new third liquid target for continuous use.
Referring to fig. 1, in one embodiment, the circulation system 3 further includes an isotope extraction system 34, the isotope extraction system 34 being coupled to the heat exchange system 32 for extracting isotopes from the monolithic liquid target. The isotope is extracted by the isotope extraction system, so that the later use of the isotope is facilitated.
Referring to fig. 1, in one embodiment, the accelerator-based isotope production solid-liquid coupled target apparatus of the present invention further comprises a first solid target delivery system 4. Wherein the first solid target delivery system 4 extends in the inner cavity of the shielding body 1 and is connected with the first solid target 21 for replacing the first solid target 21. The first solid target piece 21 can be replaced on line by arranging the first solid target transmission system 4, so that the method is convenient and quick, frequent shutdown is not needed, the equipment utilization rate is high, and the economical efficiency is good.
It should be noted that, the first solid target delivery system 4 is an existing solid target delivery system, and the specific structure is not described herein.
Referring to fig. 1, in one embodiment, the accelerator-based isotope production solid-liquid coupled target apparatus of the present invention further comprises a second solid target delivery system 5. Wherein the two solid target delivery systems 5 extend into the interior cavity of the shield 1 and are connected to the second solid target 29 for replacement of the second solid target 29. The second solid target piece 29 can be replaced on line by arranging the second solid target transmission system 5, so that the method is convenient and quick, frequent shutdown is not needed, the equipment utilization rate is high, and the economy is good.
It should be noted that, the second solid target delivery system 5 is an existing solid target delivery system, and the specific structure is not described herein.
The specific implementation process comprises the following steps:
the isotope production assembly 2 of the accelerator-based isotope production solid-liquid coupled target apparatus of the present invention is a multi-layered structure, namely, a first solid target 21, a first liquid target 22, a first multiplication layer 23, a first slowing layer 24, a second liquid target 25, a second multiplication layer 26, a second slowing layer 27, a third liquid target 28, and a second solid target 29.
The material of the first solid target 21 is BeO or Be or Li2O or Li, and the material of the first solid target 21 reacts with the high-energy proton of strong current transmitted through the proton beam channel 11 to generate neutrons through nuclear reactions of 9Be (p, n) 9B, 7Li (p, n) 7Be, and the like.
The material of the first liquid target 22 is uranyl sulfate solution or other uranium-containing solution, and the other uranium-containing solution may be uranyl sulfate solution or uranyl nitrate solution, so that isotopes and neutrons may be produced by nuclear reaction of uranium in the first liquid target 22 and neutrons generated by the first solid target 21, and heat generated by nuclear reaction of the first solid target 21, the first liquid target 22 and the first multiplication layer 23 may be taken away by flowing uranyl sulfate solution or other uranium-containing solution.
The material of the first multiplication layer 23 is any one of Be, beO, pb, bi, pbO, pb-Bi alloys, and neutrons are multiplied by (n, 2 n) or (n, 3 n) reactions to increase the number of neutrons.
The material of the first moderating layer 24 is graphite or zirconium hydride or polyethylene, and neutron energy is reduced through moderating reaction to increase the reaction rate of uranium and neutrons in the second liquid target 25, so as to increase isotope yield.
The material of the second liquid target 25 is uranyl sulfate solution or other uranium-containing solution, the uranium in the second liquid target 25 and neutrons are subjected to nuclear reaction to produce isotopes, and heat generated by nuclear reaction of the first slowing-down layer 24, the second liquid target 25 and the second multiplication layer 26 can be taken away through the flow of uranyl sulfate solution or other uranium-containing solution.
The material of the second multiplication layer 26 is Be or BeO or Pb or Bi or PbO or Pb-Bi alloy, and neutrons are multiplied by (n, 2 n) or (n, 3 n) reactions to increase the number of neutrons;
the material of the second moderating layer 27 is graphite or zirconium hydride or polyethylene, and neutron energy is reduced by moderating reaction to increase the rate of reaction of uranium with neutrons in the third liquid target 28 to increase isotope production.
The material of the third liquid target 28 is uranyl sulfate solution or other uranium-containing solution, the uranium in the third liquid target 28 and neutrons are subjected to nuclear reaction to produce isotopes, and heat generated by nuclear reaction in the second slowing layer 27, the third liquid target 28 and the second solid target piece 29 can be taken away through the flow of uranyl sulfate solution or other uranium-containing solution.
The material of the second solid state target 29 is one of N-14, co-59, Y-89, lu-176, and the corresponding one of the isotopes N-15, co-60, Y-90, lu-177 can be produced by nuclear reaction of neutrons with the material of the second solid state target 29.
According to the invention, through arranging the first solid target 21, the second solid target 29, the first liquid target 22, the second liquid target 25 and the third liquid target 28, the first multiplication layer 23, the first slowing-down layer 24, the second multiplication layer 26 and the second slowing-down layer 27, the isotope production probability of the first liquid target 22, the second liquid target 25 and the third liquid target 28 can be improved, the nuclear reaction probability of the first solid target 21 and the second solid target 29 can be improved, the isotope productivity can be further improved, the neutron source intensity can be enhanced and the neutrons can be effectively utilized through the combination of the solid targets and the liquid targets, and the isotope yield can be improved.
Thus far, the technical solution of the present invention has been described in connection with the preferred embodiments shown in the drawings, but it is easily understood by those skilled in the art that the scope of protection of the present invention is not limited to these specific embodiments. Equivalent modifications and substitutions for related technical features may be made by those skilled in the art without departing from the principles of the present invention, and such modifications and substitutions will fall within the scope of the present invention.
Claims (10)
1. An accelerator-based isotope production solid-liquid coupled target device, characterized in that the device comprises an accelerator, a shielding body and an isotope production assembly;
the accelerator is used for generating proton beam;
the shielding body is provided with a proton beam channel and an inner cavity which are communicated and used for the proton beam to enter;
the isotope production assembly is arranged in the inner cavity so that the proton beam irradiates and is used for producing isotopes for multiple times.
2. The accelerator-based isotope production solid-liquid coupled target apparatus of claim 1 wherein the isotope production assembly includes a first solid target piece, a first liquid target, a first multiplication layer, a first slowing layer, and a second liquid target;
the first solid target piece is arranged in the inner cavity and props against the proton beam flow channel so that the proton beam irradiation generates first neutrons;
the first liquid target is arranged in the inner cavity and adjacent to the first solid target piece and is used for generating reaction with the first neutrons so as to produce isotopes and second neutrons;
the first multiplication layer is arranged in the inner cavity and adjacent to the first liquid target and is used for carrying out multiplication reaction on the second neutrons;
the first moderating layer is arranged in the inner cavity and adjacent to the first multiplying layer and is used for moderating the second neutrons after the multiplication reaction;
the second liquid target is disposed in the inner cavity and adjacent to the first moderating layer for reacting with the second neutrons to produce isotopes and third neutrons.
3. The accelerator-based isotope production solid-liquid coupled target apparatus of claim 2 wherein the isotope production assembly further comprises a second multiplication layer, a second moderation layer, and a third liquid target;
the second multiplication layer is arranged in the inner cavity and adjacent to the second liquid target and is used for carrying out multiplication reaction on the third neutrons;
the second moderating layer is arranged in the inner cavity and adjacent to the second multiplying layer and is used for moderating the third neutrons after the multiplication reaction;
the third liquid target is disposed in the inner cavity and adjacent to the second moderating layer for reacting with the third neutrons to produce isotopes and fourth neutrons.
4. The accelerator-based isotope production solid-liquid coupled target apparatus of claim 3 wherein the isotope production assembly further comprises a second solid target tablet;
the second solid target is disposed in the inner cavity and adjacent to the third liquid target for reacting with the fourth neutrons to produce isotopes.
5. The accelerator-based isotope production solid-liquid coupled target apparatus of claim 4 further comprising a circulation system including a liquid target delivery system, a heat exchange system, and a drive pump;
the driving pump is respectively connected with the first liquid target, the second liquid target and the third liquid target and is used for driving and converging the first liquid target, the second liquid target and the third liquid target to form an integral liquid target;
the heat exchange system is connected with the driving pump and is used for cooling the integral liquid target;
the liquid target transmission system is connected with the heat exchange system, so that the cooled integral liquid target enters the inner cavity of the shielding body to form a new first liquid target, a new second liquid target and a new third liquid target.
6. The accelerator-based isotope production solid-liquid coupled target apparatus of claim 5 wherein the circulation system further comprises an isotope extraction system;
the isotope extraction system is connected with the heat exchange system and is used for extracting isotopes in the integral liquid target.
7. The accelerator-based isotope production solid-liquid coupled target apparatus of claim 6 wherein the heat exchange system has a coolant inlet and a coolant outlet.
8. The accelerator-based isotope production solid-liquid coupled target apparatus of claim 2 further comprising a first solid target delivery system;
the first solid target transmission system extends in the inner cavity of the shielding body and is connected with the first solid target piece for replacing the first solid target piece.
9. The accelerator-based isotope production solid-liquid coupled target apparatus of claim 4 further comprising a second solid target delivery system;
the second solid target transmission system extends in the inner cavity of the shielding body and is connected with the second solid target piece for replacing the second solid target piece.
10. The accelerator based isotope production solid-liquid coupled target device in accordance with claim 4 wherein the first solid state target is any one of BeO, be, li2O, li;
the first liquid target, the second liquid target and the third liquid target are made of uranyl sulfate solution or other uranium-containing solutions;
the materials of the first multiplication layer and the second multiplication layer are any one of Be, beO, pb, bi, pbO, pb-Bi alloy;
the first and second slowing layers are made of any one of graphite, zirconium hydride and polyethylene;
the second solid target is any one of N-14, co-59, Y-89 and Lu-176.
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Citations (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20000019823A (en) * | 1998-09-15 | 2000-04-15 | 김성년 | Apparatus for examining liquid target of radioactive isotope |
| JP2002214395A (en) * | 2001-01-12 | 2002-07-31 | Hitachi Ltd | Isotopic nuclide manufacturing device |
| RU2239900C1 (en) * | 2003-03-13 | 2004-11-10 | Закрытое акционерное общество "Циклотрон" | Method for producing radioactive isotopes cobalt-57 and cadmium-109 |
| US20050242276A1 (en) * | 2004-03-26 | 2005-11-03 | Hitachi, Ltd. | Radiosotope production apparatus and radiopharmaceutical production apparatus |
| US20090274258A1 (en) * | 2006-04-14 | 2009-11-05 | Holden Charles S | Compound isotope target assembly for production of medical and commercial isotopes by means of spectrum shaping alloys |
| KR20100042841A (en) * | 2008-10-17 | 2010-04-27 | 한국원자력연구원 | A metal target for neutron generator |
| US20110091001A1 (en) * | 2009-10-21 | 2011-04-21 | Korea Atomic Energy Research Institute | High current solid target for radioisotope production at cyclotron using metal foam |
| US20130279638A1 (en) * | 2010-11-29 | 2013-10-24 | Inter-University Research Insitute Corporation High Energy Accelerator Research | Composite type target, neutron generating method in use thereof and neutron generating apparatus in use thereof |
| KR101366689B1 (en) * | 2012-08-20 | 2014-02-25 | 한국원자력의학원 | F-18 radio isotopes water target apparatus for improving cooling performance??with internal flow channel using thermosiphon |
| RU142204U1 (en) * | 2013-10-07 | 2014-06-20 | Российская Федерация, от имени которой выступает Государственная корпорация по атомной энергии "Росатом" (Госкорпорация "Росатом") | TARGET FOR PROTON ISOTOPE GENERATION |
| US20150179290A1 (en) * | 2009-12-07 | 2015-06-25 | James E. Clayton | System and method for generating molybdenum-99 and metastable technetium-99, and other isotopes |
| US20150332799A1 (en) * | 2014-05-16 | 2015-11-19 | ISO Evolutions, LLC | Methods and apparatus for the production of isotopes |
| CN107622807A (en) * | 2017-09-20 | 2018-01-23 | 西安海达威科技有限责任公司 | It is a kind of to produce radioisotopic device and method with phot-neutron source |
| US20180322972A1 (en) * | 2017-05-04 | 2018-11-08 | General Electric Company | System and method for making a solid target within a production chamber of a target assembly |
| US20190259505A1 (en) * | 2018-02-19 | 2019-08-22 | Sumitomo Heavy Industries, Ltd. | Radioisotope production apparatus |
| CN110706840A (en) * | 2019-10-18 | 2020-01-17 | 中国科学院合肥物质科学研究院 | Accelerator driving based99Mo subcritical production device and method |
| US20210257121A1 (en) * | 2018-07-09 | 2021-08-19 | Advanced Accelerator Applications | Neutron activator, neutron activation system comprising such neutron activator and method for neutron activation implementing such neutron activator |
| WO2022031925A1 (en) * | 2020-08-07 | 2022-02-10 | Cryorad, Inc. | Ultra efficient accelerator production of isotopically pure actinium-225 |
| CN115410744A (en) * | 2022-08-18 | 2022-11-29 | 中国原子能科学研究院 | Multilayer target with shielding function |
| CN115499993A (en) * | 2022-10-21 | 2022-12-20 | 中子高新技术产业发展(重庆)有限公司 | Neutron target system |
-
2023
- 2023-03-20 CN CN202310274417.6A patent/CN116705375B/en active Active
Patent Citations (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20000019823A (en) * | 1998-09-15 | 2000-04-15 | 김성년 | Apparatus for examining liquid target of radioactive isotope |
| JP2002214395A (en) * | 2001-01-12 | 2002-07-31 | Hitachi Ltd | Isotopic nuclide manufacturing device |
| RU2239900C1 (en) * | 2003-03-13 | 2004-11-10 | Закрытое акционерное общество "Циклотрон" | Method for producing radioactive isotopes cobalt-57 and cadmium-109 |
| US20050242276A1 (en) * | 2004-03-26 | 2005-11-03 | Hitachi, Ltd. | Radiosotope production apparatus and radiopharmaceutical production apparatus |
| US20090274258A1 (en) * | 2006-04-14 | 2009-11-05 | Holden Charles S | Compound isotope target assembly for production of medical and commercial isotopes by means of spectrum shaping alloys |
| KR20100042841A (en) * | 2008-10-17 | 2010-04-27 | 한국원자력연구원 | A metal target for neutron generator |
| US20110091001A1 (en) * | 2009-10-21 | 2011-04-21 | Korea Atomic Energy Research Institute | High current solid target for radioisotope production at cyclotron using metal foam |
| US20150179290A1 (en) * | 2009-12-07 | 2015-06-25 | James E. Clayton | System and method for generating molybdenum-99 and metastable technetium-99, and other isotopes |
| US20130279638A1 (en) * | 2010-11-29 | 2013-10-24 | Inter-University Research Insitute Corporation High Energy Accelerator Research | Composite type target, neutron generating method in use thereof and neutron generating apparatus in use thereof |
| KR101366689B1 (en) * | 2012-08-20 | 2014-02-25 | 한국원자력의학원 | F-18 radio isotopes water target apparatus for improving cooling performance??with internal flow channel using thermosiphon |
| RU142204U1 (en) * | 2013-10-07 | 2014-06-20 | Российская Федерация, от имени которой выступает Государственная корпорация по атомной энергии "Росатом" (Госкорпорация "Росатом") | TARGET FOR PROTON ISOTOPE GENERATION |
| US20150332799A1 (en) * | 2014-05-16 | 2015-11-19 | ISO Evolutions, LLC | Methods and apparatus for the production of isotopes |
| US20180322972A1 (en) * | 2017-05-04 | 2018-11-08 | General Electric Company | System and method for making a solid target within a production chamber of a target assembly |
| CN107622807A (en) * | 2017-09-20 | 2018-01-23 | 西安海达威科技有限责任公司 | It is a kind of to produce radioisotopic device and method with phot-neutron source |
| US20190259505A1 (en) * | 2018-02-19 | 2019-08-22 | Sumitomo Heavy Industries, Ltd. | Radioisotope production apparatus |
| CN110176323A (en) * | 2018-02-19 | 2019-08-27 | 住友重机械工业株式会社 | Radioactive isotope manufacturing device |
| US20210257121A1 (en) * | 2018-07-09 | 2021-08-19 | Advanced Accelerator Applications | Neutron activator, neutron activation system comprising such neutron activator and method for neutron activation implementing such neutron activator |
| CN110706840A (en) * | 2019-10-18 | 2020-01-17 | 中国科学院合肥物质科学研究院 | Accelerator driving based99Mo subcritical production device and method |
| WO2022031925A1 (en) * | 2020-08-07 | 2022-02-10 | Cryorad, Inc. | Ultra efficient accelerator production of isotopically pure actinium-225 |
| CN115410744A (en) * | 2022-08-18 | 2022-11-29 | 中国原子能科学研究院 | Multilayer target with shielding function |
| CN115499993A (en) * | 2022-10-21 | 2022-12-20 | 中子高新技术产业发展(重庆)有限公司 | Neutron target system |
Non-Patent Citations (1)
| Title |
|---|
| SERGIO J. C. DO CARMO1 ET AL.: "Production of radiometals in liquid targets", EJNMMI RADIOPHARMACY AND CHEMISTRY, no. 2, 10 January 2020 (2020-01-10), pages 1 - 21 * |
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