CN116259431B - Isotope production solid-state target device based on accelerator - Google Patents
Isotope production solid-state target device based on accelerator Download PDFInfo
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- CN116259431B CN116259431B CN202310271559.7A CN202310271559A CN116259431B CN 116259431 B CN116259431 B CN 116259431B CN 202310271559 A CN202310271559 A CN 202310271559A CN 116259431 B CN116259431 B CN 116259431B
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- 238000006243 chemical reaction Methods 0.000 claims description 14
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- 238000001816 cooling Methods 0.000 claims description 9
- 238000007599 discharging Methods 0.000 claims description 6
- 229910001152 Bi alloy Inorganic materials 0.000 claims description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 5
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- QSGNKXDSTRDWKA-UHFFFAOYSA-N zirconium dihydride Chemical compound [ZrH2] QSGNKXDSTRDWKA-UHFFFAOYSA-N 0.000 claims description 5
- 229910000568 zirconium hydride Inorganic materials 0.000 claims description 5
- 239000003814 drug Substances 0.000 description 5
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- 238000003745 diagnosis Methods 0.000 description 4
- NMFHJNAPXOMSRX-PUPDPRJKSA-N [(1r)-3-(3,4-dimethoxyphenyl)-1-[3-(2-morpholin-4-ylethoxy)phenyl]propyl] (2s)-1-[(2s)-2-(3,4,5-trimethoxyphenyl)butanoyl]piperidine-2-carboxylate Chemical compound C([C@@H](OC(=O)[C@@H]1CCCCN1C(=O)[C@@H](CC)C=1C=C(OC)C(OC)=C(OC)C=1)C=1C=C(OCCN2CCOCC2)C=CC=1)CC1=CC=C(OC)C(OC)=C1 NMFHJNAPXOMSRX-PUPDPRJKSA-N 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
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- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/10—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by bombardment with electrically charged particles
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/06—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by neutron irradiation
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E30/00—Energy generation of nuclear origin
- Y02E30/10—Nuclear fusion reactors
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- High Energy & Nuclear Physics (AREA)
- Particle Accelerators (AREA)
Abstract
The invention relates to the technical field of isotope production, in particular to an accelerator-based isotope production solid target device, which aims to solve the problem of low production efficiency caused by low isotope yield of the existing isotope production solid target device. For this purpose, the accelerator-based isotope production solid state target device of the present invention comprises: an accelerator, a shield, a first target, and a second target; the accelerator is used for generating proton beam; the shielding body is provided with a proton beam channel, and the first target piece is arranged in the inner cavity of the shielding body and props against the outlet of the proton beam channel so as to produce a first group of isotopes and neutrons; the second target is arranged in the inner cavity of the shielding body and is positioned behind the first target, and a second group of isotopes is produced. Through setting up first target and second target, first target can produce first group isotope and neutron simultaneously, and this neutron irradiation second target can produce second group isotope, can improve the production isotope productivity, and then promotes production efficiency.
Description
Technical Field
The invention relates to the technical field of isotope production, and particularly provides an accelerator-based isotope production solid-state target device.
Background
The medical isotope medicament is the key of important medical diagnosis and treatment, such as medical isotopes of Ge-68, tc-99m, lu-177, Y-90, ac-225 and the like, can be prepared into medicaments for in vivo diagnosis medicaments, in vitro diagnosis medicaments, radioactive medicaments for treatment and the like, and has irreplaceable advantages in the fields of diagnosis and treatment of serious diseases such as cardiovascular and cerebrovascular diseases, malignant tumors, nerve degeneration and the like.
At present, isotope production mainly produces 235U or target materials through irradiation in a reactor, and has the defects of complex process, high cost, long-distance transportation loss and the like, and nuclear diffusion risks.
In recent years, there have been cases where isotope production is performed using an accelerator in an isotope production solid-state target apparatus, and the above-described problems have been solved, but the production of isotopes using an accelerator has been low in yield, resulting in low isotope production efficiency.
Accordingly, there is a need in the art for an accelerator-based isotope production solid state target apparatus that addresses the above-described issues.
Disclosure of Invention
The invention aims to solve the technical problems, namely the problems of low isotope yield and low isotope production efficiency of the existing isotope production solid-state target device.
The invention provides an accelerator-based isotope production solid-state target device, which comprises an accelerator, a shielding body, a first target piece and a second target piece; the accelerator is used for generating proton beam; the shielding body is provided with a proton beam channel for entering proton beam generated by the accelerator; the first target is arranged in the inner cavity of the shielding body and is propped against the outlet of the proton beam channel, so that the first target is subjected to reaction when the proton beam irradiates the first target to produce a first group of isotopes and neutrons; the second target is disposed in the interior cavity of the shield and behind the first target such that neutrons irradiate the second target to produce a second set of isotopes.
Under the condition that the technical scheme is adopted, the solid-state target device comprises an accelerator, a shielding body, a first target piece and a second target piece, wherein the accelerator is used for generating proton beam current, the shielding body is provided with a proton beam current channel and is used for enabling proton beam current generated by the accelerator to enter, the first target piece is arranged in an inner cavity of the shielding body and props against an outlet of the proton beam current channel so that the proton beam current irradiates the first target piece to react to generate a first group of isotopes and neutrons, the second target piece is arranged in the inner cavity of the shielding body and is positioned behind the first target piece so that the secondary target piece irradiates the second target piece to generate a second group of isotopes, and the first target piece can simultaneously generate the first group of isotopes and the neutrons by arranging the first target piece and the second target piece, so that the production capacity of isotopes can be improved, the production efficiency can be improved, and the cost can be reduced.
In the preferred technical scheme of the solid-state target device for producing the isotopes based on the accelerator, the first target piece is made of any one of Ga-69, mo-100, ra-226 and Cd-112; the second target is made of any one of N-14, co-59, Y-89 and Lu-176.
Under the condition of adopting the technical scheme, the first target adopts any one of Ga-69, mo-100, ra-226 and Cd-112 as a material, and the second target adopts any one of N-14, co-59, Y-89 and Lu-176 as a material, so that various isotopes can be produced.
In a preferred embodiment of the above accelerator-based isotope production solid state target device, the first group of isotopes is any one of Ge-68, tc-99m, ac-225, in-111; the second group of isotopes is any one of N-15, co-60, Y-90 and Lu-177.
Under the condition of adopting the technical scheme, isotopes Ge-68, tc-99m, ac-225, in-111, N-15, co-60, Y-90 and Lu-177 produced by the invention can be used In the medical field.
In the preferred technical scheme of the solid target device based on the isotope production of the accelerator, the solid target device further comprises an air cooling structure, wherein the air cooling structure comprises an air inlet pipe, an air outlet pipe, a first air cavity and a second air cavity; the air inlet pipe is arranged in the inner cavity of the shielding body; the air outlet pipe is inserted into the inner cavity of the shielding body; the first air cavity is adjacent to the first target, the first air cavity is connected with the air inlet pipe and used for cooling the first target when cold air enters the first target, and the first air cavity is connected with the air outlet pipe and used for discharging the cold air; the second air cavity is adjacent to the second target, the second air cavity is connected with the air inlet pipe and used for cooling the second target after cold air enters, and the second air cavity is connected with the air outlet pipe and used for discharging the cold air.
Under the condition of adopting the technical scheme, the invention is provided with the air inlet pipe, the air outlet pipe, the first air cavity and the second air cavity which are connected, wherein the first air cavity is used for taking away the heat generated by the reaction of the first target, and the second air cavity is used for taking away the heat generated by the reaction of the second target, so that the influence caused by the overhigh temperature of the first target and the second target is avoided.
In a preferred embodiment of the above accelerator-based isotope production solid state target device, the solid state target device further includes a neutron multiplication layer disposed between the first air chamber and the second target piece for reacting the neutrons to multiply the neutrons.
Under the condition of adopting the technical scheme, the invention reacts on neutrons by adding the neutron multiplication layer so as to increase the quantity of neutrons, thereby being beneficial to the production of isotopes by the second target.
In the above preferred technical solution for producing a solid-state target device based on an isotope of an accelerator, the neutron multiplication layer is made of: be. BeO, pb, bi, pbO, pb-Bi alloy.
Under the condition of adopting the technical scheme, the invention can effectively increase the quantity of neutrons by taking any one of Be, beO, pb, bi, pbO, pb-Bi alloy as the material of the neutron multiplication layer so as to facilitate the second target to produce isotopes, thereby improving the yield of the second group of isotopes.
In a preferred embodiment of the above accelerator-based isotope production solid state target device, the solid state target device further includes a moderating layer disposed between the neutron multiplication layer and the second target piece for moderating the neutrons after multiplication to reduce neutron energy.
Under the condition of adopting the technical scheme, the invention is used for slowing down the multiplied neutrons by arranging the slowing-down layer so as to reduce neutron energy, thereby improving the reaction efficiency of the second target.
In the preferred technical scheme of the solid-state target device for producing isotopes based on the accelerator, the material of the slowing layer is any one of graphite, zirconium hydride and polyethylene.
Under the condition of adopting the technical scheme, any one of graphite, zirconium hydride and polyethylene is used as a material of the slowing layer, so that the slowing capability is good, and the reaction of the second target is facilitated.
In a preferred embodiment of the above accelerator-based isotope production solid state target device, the solid state target device further comprises a first solid target delivery system extending within the interior cavity of the shield and coupled to the first target for replacement of the first target.
Under the condition of adopting the technical scheme, the first target piece can be replaced on line by arranging the first solid target transmission system, so that the method is convenient and quick.
In a preferred embodiment of the above accelerator-based isotope production solid state target device, the solid state target device further comprises a second solid state target delivery system extending within the interior cavity of the shield and coupled to the second target for replacement of the second target.
Under the condition of adopting the technical scheme, the second target piece can be replaced on line by arranging the second solid target transmission system, so that convenience and rapidness are realized.
Drawings
Preferred embodiments of the present invention are described below with reference to the accompanying drawings, in which:
fig. 1 is a cross-sectional view of an accelerator-based isotope production solid state target apparatus of the present invention.
The marks in the figure:
1. a shield; 2. a first target; 3. a first solid target delivery system; 4. a second solid target delivery system; 5. an air inlet pipe; 6. a second air chamber; 7. an air outlet pipe; 8. a second target; 9. a slowing layer; 10. a neutron multiplication layer; 11. a first air chamber; 12. proton beam passage.
Detailed Description
Preferred embodiments of the present invention are described below with reference to the accompanying drawings. It will be appreciated by those skilled in the art that these embodiments are merely illustrative of the principles of the present invention for accelerator-based isotope production solid state target apparatus and are not intended to limit the scope of the present invention.
It should be noted that in the description of the present invention, furthermore, the terms "first," "second," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
Furthermore, it should be noted that, in the description of the present invention, unless explicitly specified and limited otherwise, the terms "disposed," "connected" and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be directly connected, can be indirectly connected through an intermediate medium, and can also be communicated with the inside of two elements. The specific meaning of the above terms in the present invention can be understood by those skilled in the art according to the specific circumstances.
Referring first to fig. 1, the accelerator-based isotope production solid state target apparatus of the present invention generally includes an accelerator (not shown), a shield 1, a first target 2, and a second target 8. Wherein the accelerator is used for generating proton beam, the shielding body 1 is provided with a proton beam channel 12 for entering the proton beam generated by the accelerator. The first target 2 is disposed in the inner cavity of the shielding body 1 and abuts against the outlet of the proton beam channel 12, so that the proton beam irradiates the first target 2 to react, and a first group of isotopes and neutrons are produced. A second target 8 is disposed in the interior cavity of the shield 1 and behind the first target 2 so that the second target 8 is irradiated by the electrons to produce a second set of isotopes. By arranging the first target 2 and the second target 8, the first target 2 can produce the first group of isotopes and neutrons at the same time, and the second target 8 can produce the second group of isotopes by the neutron irradiation, so that the isotope production capacity can be improved, the production efficiency can be improved, and the cost can be reduced.
With continued reference to fig. 1, in particular, the accelerator is disposed on the front side of the shielding body 1, and the shielding body 1 is generally a column, not limited to the column, but may be other shapes such as a rectangular body, etc. The shielding body 1 is provided with a shell, the inside of the shell is filled with filling materials, a proton beam channel 12 is arranged on the rear side of the shielding body 1, an end of an inlet of the proton beam channel 12 and an accelerator are arranged in an application mode, a cavity (not marked in the figure) is formed in the inside of the shielding body 1, a first target 2 is arranged in the cavity and positioned at an outlet of the proton beam channel 12, so that protons irradiate the first target 2 and are used for generating a first group of isotopes and neutrons, and a second target 8 is arranged in the cavity and positioned on the rear side of the first target 2 and is used for generating a second group of isotopes for the neutron reaction.
Wherein the proton beam channel 12 provides proton beam with energy of 20-35MeV and flow intensity of 200-2000 uA. Preferably, the energy is 30MeV and the flow strength is 600uA.
With continued reference to fig. 1, in this embodiment, the first target 2 and the second target 8 have the same shape, typically a wafer or a rectangular sheet, and the proton beam channel 12 has a generally circular or rectangular cross-sectional shape, so as to be consistent with the first target 2 and the second target 8, thereby meeting the basic requirements.
Further, the first target 2 and the second target 8 are coaxially arranged, so that adverse effects in the reaction are avoided.
Referring to FIG. 1, in one embodiment, the first target 2 is made of any one of Ga-69, mo-100, ra-226, cd-112, and the second target 8 is made of any one of N-14, co-59, Y-89, lu-176. The first target 2 is made of any one of Ga-69, mo-100, ra-226 and Cd-112, and is used for reacting with protons p and 2n to generate a first group of isotopes and neutrons. The second target adopts any one of N-14, co-59, Y-89 and Lu-176 as a material, and is used for generating N and gamma reactions with neutrons to generate a second group of isotopes, thereby producing a plurality of different isotopes.
Further, the first group of isotopes is any one of Ge-68, tc-99m, ac-225 and In-111, and the second group of isotopes is any one of N-15, co-60, Y-90 and Lu-177.
Referring to fig. 1, in one embodiment, the solid state target device of the present invention further comprises an air cooling structure generally comprising an air inlet 5, an air outlet 7, a first air chamber 11 and a second air chamber 6. The air inlet pipe 5 is arranged in the inner cavity of the shielding body 1, the air outlet pipe 7 is inserted in the inner cavity of the shielding body 1, the first air cavity 11 is adjacent to the first target piece 2, the first air cavity 11 is connected with the rear end of the air inlet pipe 5 and used for cooling the first target piece 2 when cold air enters, the first air cavity 11 is connected with the rear end of the air outlet pipe 7 and used for discharging the cold air, the second air cavity 6 is adjacent to the second target piece 8 and connected with the air inlet pipe 5 and used for cooling the second target piece 8 when the cold air enters, and the second air cavity 6 is connected with the air outlet pipe 7 and used for discharging the cold air. Through setting up intake pipe 5, outlet duct 7, first air cavity 11 and the second air cavity 6 that are connected, and first air cavity 11 is used for taking away the heat that first target piece 2 reaction produced, and second air cavity 6 is used for taking away the heat that second target piece 8 reaction produced, and then avoids first target piece 2 and second target piece 8 high temperature to cause the influence.
With continued reference to fig. 1, specifically, the front end of the air intake pipe 5 is connected to a cold air circulation device, which is generally an existing cold air circulation device, but may also be an air conditioner. The air intake pipe 5 is located at the upper side of the inside of the shield body 1. The front end of the air outlet pipe 7 is connected with the cold air circulation device. The first air cavity 11 is a disc cavity, and the second air cavity 6 is a disc cavity.
Referring to fig. 1, in one embodiment, the solid state target device of the present invention further comprises a neutron multiplication layer 10, the neutron multiplication layer 10 being disposed between the first gas chamber 11 and the second target 8 for reacting neutrons to multiply the neutrons. By adding neutron multiplication layer 10, the neutrons can be reacted to increase the number of neutrons, facilitating the production of isotopes by second target 8.
The neutron multiplication layer 10 is round or rectangular, has the same shape as the first target 2 and the first gas cavity 11, is convenient for reacting neutrons, and has a neat structure and is convenient to install.
In this embodiment, the neutron multiplication layer 10 is made of: be. BeO, pb, bi, pbO, pb-Bi alloy. By using any one of the Be, beO, pb, bi, pbO, pb-Bi alloys as the material for the neutron multiplication layer 10, n,2n or n,3n reactions can be generated that effectively increase the number of neutrons for the second target 8 to produce isotopes in order to increase the yield of the second set of isotopes.
Referring to fig. 1, in one embodiment, the solid state target device of the present invention further comprises a moderating layer 9, the moderating layer 9 being disposed between the neutron multiplication layer 10 and the second target 8 for moderating the neutrons after multiplication to reduce neutron energy. The moderation layer 9 is used for moderating the multiplied neutrons so as to reduce neutron energy, and further improve the reaction efficiency of the second target 8.
In this embodiment, the material of the slowing layer 9 is any one of graphite, zirconium hydride, and polyethylene. By using any one of graphite, zirconium hydride and polyethylene as the material of the slowing layer 9, the slowing capability is better, which is beneficial to the reaction of the second target 8.
Referring to fig. 1, in one embodiment, the solid target device of the present invention further comprises a first solid target delivery system 3, wherein the first solid target delivery system 3 extends into the inner cavity of the shielding body 1 and is connected with the first target 2 for replacing the first target 2. The first target piece 2 can be replaced on line by arranging the first solid target transmission system 3, so that convenience and rapidness are realized. The second target 8 is replaced without frequent shutdown, so that the equipment utilization rate is high and the economy is good.
Wherein the first solid target delivery system 3 is an existing solid target delivery system, and the specific structure thereof will not be described in detail herein.
Referring to fig. 1, in one embodiment, the solid state target device of the present invention further comprises a second solid target delivery system 4, the second solid target delivery system 4 extending within the interior cavity of the shield 1 and being coupled to the second target 8 for replacement of the second target 8. The second target 8 can be replaced on line by arranging the second solid target transmission system 4, so that convenience and rapidness are realized. The second target 8 is replaced without frequent shutdown, so that the equipment utilization rate is high and the economy is good. Wherein the second solid target delivery system 4 is an existing solid target delivery system, and the specific structure thereof will not be described in detail herein.
Thus far, the technical solution of the present invention has been described in connection with the preferred embodiments shown in the drawings, but it is easily understood by those skilled in the art that the scope of protection of the present invention is not limited to these specific embodiments. Equivalent modifications and substitutions for related technical features may be made by those skilled in the art without departing from the principles of the present invention, and such modifications and substitutions will fall within the scope of the present invention.
Claims (8)
1. An accelerator-based isotope production solid state target device, wherein the solid state target device comprises an accelerator, a shield, a first target piece, and a second target piece;
the accelerator is used for generating proton beam;
the shielding body is provided with a proton beam channel for the proton beam to enter;
the first target is arranged in the inner cavity of the shielding body and is propped against the outlet of the proton beam channel, so that the first target is subjected to reaction when the proton beam irradiates the first target to produce a first group of isotopes and neutrons;
the second target is arranged in the inner cavity of the shielding body and is positioned behind the first target so that neutrons irradiate the second target to produce a second group of isotopes;
the first target piece is made of any one of Ga-69, mo-100, ra-226 and Cd-112; the second target is made of any one of N-14, co-59, Y-89 and Lu-176; the first group of isotopes are any one of Ge-68, tc-99m, ac-225 and In-111; the second group of isotopes is any one of N-15, co-60, Y-90 and Lu-177.
2. The accelerator-based isotope production solid state target apparatus of claim 1 further comprising an air cooled structure comprising an air inlet tube, an air outlet tube, a first air cavity, and a second air cavity;
the air inlet pipe is arranged in the inner cavity of the shielding body;
the air outlet pipe is inserted into the inner cavity of the shielding body;
the first air cavity is adjacent to the first target, the first air cavity is connected with the rear end of the air inlet pipe and used for cooling the first target when cold air enters the first target, and the first air cavity is connected with the rear end of the air outlet pipe and used for discharging the cold air;
the second air cavity is adjacent to the second target, the second air cavity is connected with the air inlet pipe and used for cooling the second target after cold air enters, and the second air cavity is connected with the air outlet pipe and used for discharging the cold air.
3. The accelerator-based isotope production solid state target apparatus of claim 2 further comprising a neutron multiplication layer disposed between the first air cavity and the second target piece for reacting the neutrons to multiply the neutrons.
4. The accelerator-based isotope production solid state target device in accordance with claim 3 wherein the neutron multiplication layer is of a material: be. BeO, pb, bi, pbO, pb-Bi alloy.
5. The accelerator-based isotope production solid state target apparatus of claim 4 further comprising a moderating layer disposed between the neutron multiplication layer and the second target sheet for moderating the neutrons after multiplication to reduce neutron energy.
6. The accelerator-based isotope production solid state target device in accordance with claim 5 wherein the material of the moderating layer is any one of graphite, zirconium hydride, polyethylene.
7. The accelerator based isotope production solid target device of any one of claims 1-6, further comprising a first solid target delivery system extending within the interior cavity of the shield and coupled to the first target for replacement of the first target.
8. The accelerator based isotope production solid target device of any one of claims 1-6, further comprising a second solid target delivery system extending within the interior cavity of the shield and coupled to the second target for replacement of the second target.
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| CN202310271559.7A CN116259431B (en) | 2023-03-20 | 2023-03-20 | Isotope production solid-state target device based on accelerator |
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| CN202310271559.7A CN116259431B (en) | 2023-03-20 | 2023-03-20 | Isotope production solid-state target device based on accelerator |
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| CN117727482A (en) * | 2023-12-21 | 2024-03-19 | 中国科学技术大学 | Simultaneous production of isotopes 99 Mo and 99m tc method and device |
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| US9177679B2 (en) * | 2010-02-11 | 2015-11-03 | Uchicago Argonne, Llc | Accelerator-based method of producing isotopes |
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| CN110706840A (en) * | 2019-10-18 | 2020-01-17 | 中国科学院合肥物质科学研究院 | Accelerator driving based99Mo subcritical production device and method |
| CN213426551U (en) * | 2020-09-11 | 2021-06-11 | 四川玖谊源粒子科技有限公司 | Self-shielding target body of cyclotron |
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