CN116676182A - Full-automatic defoaming control device and method for bioreactor or fermentation tank - Google Patents
Full-automatic defoaming control device and method for bioreactor or fermentation tank Download PDFInfo
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- CN116676182A CN116676182A CN202310858030.5A CN202310858030A CN116676182A CN 116676182 A CN116676182 A CN 116676182A CN 202310858030 A CN202310858030 A CN 202310858030A CN 116676182 A CN116676182 A CN 116676182A
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- 238000000855 fermentation Methods 0.000 title claims abstract description 28
- 230000004151 fermentation Effects 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims abstract description 25
- 239000006260 foam Substances 0.000 claims abstract description 185
- 238000001514 detection method Methods 0.000 claims abstract description 171
- 238000011282 treatment Methods 0.000 claims abstract description 19
- 230000002572 peristaltic effect Effects 0.000 claims description 10
- 239000007788 liquid Substances 0.000 description 7
- 239000002518 antifoaming agent Substances 0.000 description 5
- 238000004113 cell culture Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G08—SIGNALLING
- G08B—SIGNALLING OR CALLING SYSTEMS; ORDER TELEGRAPHS; ALARM SYSTEMS
- G08B21/00—Alarms responsive to a single specified undesired or abnormal condition and not otherwise provided for
- G08B21/18—Status alarms
- G08B21/24—Reminder alarms, e.g. anti-loss alarms
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/02—Means for regulation, monitoring, measurement or control, e.g. flow regulation of foam
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
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- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
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- Computer Hardware Design (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention relates to a full-automatic defoaming control device and method for a bioreactor or a fermentation tank, wherein the device comprises the following components: a first foam detection part and a second foam detection part vertically disposed at the center of the top of the bioreactor or the fermenter; a third foam detection part and a fourth foam detection part horizontally disposed at an upper side of the bioreactor or the fermenter; a defoaming device for performing defoaming treatment when foam in the bioreactor or the fermenter overflows; and the control device is used for controlling the defoaming device to perform defoaming treatment according to signals from the first foam detection part, the second foam detection part, the third foam detection part and the fourth foam detection part. According to the invention, the technical problem that defoaming cannot be accurately controlled is solved, the foam height can be fully automatically and accurately controlled, and an unattended function is realized.
Description
Technical Field
The invention relates to the field of cell culture or microbial fermentation, in particular to a full-automatic defoaming control device and method for a bioreactor or a fermentation tank.
Background
Cell culture or microbial fermentation requires fermentation by liquid surface culture. The culture medium contains protein surfactant, and foam is easy to appear under the condition of ventilation. Foam can cause a number of adverse factors such as reduced fill factor of the fermenter, etc. If the foam is serious, fermentation liquid can overflow from the exhaust pipe or the shaft seal, so that the chance of bacteria infection is greatly increased. As the foam builds up, the overall foam height increases, and when the height exceeds the maximum height of the tank, the foam may flow into the exhaust line and even into the exhaust filter element with the airflow in the tank, causing the filter element to wet and clog. Thus, the foam needs to be detected and eliminated.
In the prior art, a detection device is usually arranged at the top of the tank body, and after the detection device detects foam, an alarm of the system is triggered, and the defoaming agent is started. However, this approach has the disadvantage that, due to the fixed length and position of the individual detection devices, the detection devices are at risk of foam spillage or excessive defoamer addition upon failure or false alarm. In addition, a single detection device can only provide a switching value signal, after the defoaming agent is added, whether the foam is changed or not and the changing speed cannot be known, so that the adding control of the defoaming agent cannot be accurate, and excessive adding and accurate adding cannot be prevented. The final accumulation shape of the foam in the tank is uncertain, and the foam can be in the shape of iceberg or in the shape of high periphery of a low-lying part in the middle, and the accurate judgment of liquid levels in different shapes cannot be made.
Therefore, whether to provide an improved full-automatic defoaming control device and method for a bioreactor or a fermentation tank based on the defects in the prior art becomes a technical problem to be solved urgently by those skilled in the art.
Disclosure of Invention
Problems to be solved by the invention
The invention aims to overcome the defects of the prior art and provide an improved full-automatic defoaming control device and method for a bioreactor or a fermentation tank. According to the improved full-automatic defoaming control device and method for the bioreactor or the fermentation tank, the technical problem that defoaming cannot be accurately controlled is solved, the foam height can be fully automatically and accurately controlled, and an unattended function is realized.
Means for solving the problems
The first aspect of the present invention relates to a full-automatic defoaming control apparatus for a bioreactor or a fermenter, comprising:
a first foam detection part and a second foam detection part vertically disposed at the center of the top of the bioreactor or the fermenter;
a third foam detection part and a fourth foam detection part horizontally disposed at an upper side of the bioreactor or the fermenter;
a defoaming device connected with the bioreactor or the fermentation tank and used for defoaming treatment when foam in the bioreactor or the fermentation tank overflows;
a control device for controlling the defoaming device to perform defoaming treatment according to signals from the first foam detection part, the second foam detection part, the third foam detection part and the fourth foam detection part,
the length of the first foam detection part is smaller than that of the second foam detection part and the first foam detection part and the second foam detection part are not connected in the bioreactor or the fermentation tank,
the third foam detection part and the fourth foam detection part have the same length and are positioned higher than the fourth foam detection part in the bioreactor or the fermentation tank.
Preferably, inside the bioreactor or the fermenter, the ends of the third foam detection section and the fourth foam detection section are located in the middle of the bioreactor or the fermenter, the ends of the third foam detection section being lower than the ends of the first foam detection section, the ends of the second foam detection section being lower than the ends of the fourth foam detection section.
Preferably, the first foam detection portion and the second foam detection portion are detection electrodes.
Preferably, the third foam detection portion and the fourth foam detection portion are detection electrodes.
Preferably, the defoaming device comprises a peristaltic pump and a valve.
The second aspect of the present invention relates to a full-automatic defoaming control method for a bioreactor or a fermenter, defoaming is performed by using the full-automatic defoaming control apparatus for a bioreactor or a fermenter according to the first aspect of the present invention, the method comprises the steps of:
a detection step of detecting signals from the first and second and third and fourth foam detection sections;
a control step of sending a defoaming control instruction to the defoaming device according to the detection signal obtained in the detection step;
and defoaming, namely performing corresponding defoaming action according to the defoaming control instruction.
Preferably, the defoaming control instruction includes a first defoaming control instruction,
when the detection signal is a signal which only receives any one of the first foam detection part and the second foam detection part and the third foam detection part and the fourth foam detection part, or a signal which only receives the first foam detection part and the third foam detection part, or a signal which only receives the first foam detection part and the second foam detection part and the fourth foam detection part, a first defoaming control instruction is sent to the defoaming device,
the defoaming action corresponding to the first defoaming control instruction is not performed and an alarm is sent.
Preferably, the defoaming control instruction includes a second defoaming control instruction,
when the detection signals are all four signals received by the first foam detection part, the second foam detection part, the third foam detection part and the fourth foam detection part, a second defoaming control instruction is sent to the defoaming device,
the defoaming action corresponding to the second defoaming control instruction is used for defoaming treatment and reducing the rotating speed of the bioreactor or the fermentation tank.
Preferably, the defoaming control instruction includes a third defoaming control instruction,
when the detection signal is a signal of receiving at least one of the first foam detection portion and the second foam detection portion and the third foam detection portion and the fourth foam detection portion, when the first defoaming control instruction is not sent to the defoaming device and the second defoaming control instruction is not sent to the defoaming device, the third defoaming control instruction is sent to the defoaming device,
and defoaming action corresponding to the third defoaming control instruction is used for defoaming treatment.
ADVANTAGEOUS EFFECTS OF INVENTION
According to the improved full-automatic defoaming control device and method for the bioreactor or the fermentation tank, which are provided by the invention, the technical problem that defoaming cannot be accurately controlled is solved, the foam height can be fully automatically and accurately controlled, and an unattended function is realized.
Drawings
Fig. 1 is a schematic view of a full-automatic defoaming control apparatus of a bioreactor or fermenter according to a first embodiment of the present invention.
Fig. 2 is a flowchart of a full-automatic defoaming control method according to a second embodiment of the present invention.
Detailed Description
Hereinafter, the fully automatic defoaming control apparatus and method for a bioreactor or fermenter according to the present invention will be described in detail.
Fig. 1 is a schematic diagram of a full-automatic defoaming control apparatus for a fermenter 1 according to a first embodiment of the present invention. As shown in fig. 1, a first foam detection unit A1 and a second foam detection unit B1 are vertically provided in the center of the top of the fermenter 1. The length of the first foam detection portion A1 is smaller than the length B1 of the second foam detection portion. Inside the fermenter 1, the first foam detecting part A1 and the second foam detecting part B1 are not connected to each other.
In the upper side of the fermenter 1, a third foam detecting unit A2 and a fourth foam detecting unit B2 are horizontally provided. In particular, the upper portion of the side refers to the uppermost one third of the length of the entire side. The third foam detection portion A2 and the fourth foam detection portion B2 have the same length. Inside the fermenter 1, the third foam detecting section A2 is located higher than the fourth foam detecting section B2, and as shown in FIG. 1, the third foam detecting section A2 is located above the fourth foam detecting section B2 in FIG. 1.
In fig. 1, inside the fermenter 1, the ends (right-side ends in fig. 1) of the third foam detection part A2 and the fourth foam detection part B2 are located in the middle of the fermenter 1, that is, in a position where the right-side ends in the horizontal direction reach the approximate center of the fermenter 1. The end (right end in fig. 1) of the third foam detection portion A2 is lower than the end (lower end in fig. 1) of the first foam detection portion A1, and the end (lower end in fig. 1) of the second foam detection portion B1 is lower than the end (right end in fig. 1) of the fourth foam detection portion B2. However, the positions of the end portions of the four foam detection portions are not limited to the one shown in fig. 1, and the positional relationship of the four foam detection portions with respect to each other may be appropriately adjusted according to the detection requirements.
In fig. 1, peristaltic pump 3 is connected to fermenter 1 via valve 2. Peristaltic pump 3 and valve 2 constitute a defoaming device, but are not limited thereto, and the defoaming device may also include other suitable components.
In addition, although not shown in fig. 1, the full-automatic defoaming control apparatus further includes a control apparatus. The control device controls the defoaming device to perform defoaming processing according to signals from the first foam detection part A1, the second foam detection part B1, the third foam detection part A2 and the fourth foam detection part B2.
As described above, the first embodiment can better determine the condition of the foam by using four foam detection sections having different positions. Compared with the prior art, the adding amount of the defoaming agent is more controllable and more accurate, the false alarm and the false action of the device due to the false alarm can be better eliminated, the foam liquid level height can be fully and automatically controlled according to various liquid level shapes, and the risk caused by manual operation is eliminated.
Preferably, the first and second foam detection portions A1 and B1 are detection electrodes, and the third and fourth foam detection portions A2 and B2 are detection electrodes, but not limited thereto, and may be other suitable detection members, such as a sensor, etc.
Therefore, the full-automatic defoaming control device for the bioreactor or the fermentation tank solves the technical problem that defoaming cannot be accurately controlled, can fully automatically and accurately control the foam height, and realizes an unattended function.
The second aspect of the present invention relates to a full-automatic defoaming control method for a bioreactor or a fermenter, which adopts the full-automatic defoaming control device for the fermenter 1 of the first aspect of the present invention to perform defoaming. As shown in fig. 2, the method includes: a detection step 101, a control step 102 and a defoaming step 103.
Specifically, in the detection step 101, signals from the first foam detection section A1 and the second foam detection section B1 and the third foam detection section A2 and the fourth foam detection section B2 are detected. That is, if the foam touches the corresponding foam detecting portion, the touched foam detecting portion emits a signal, and the signal is detected.
In the control step 102, a defoaming control instruction is sent to the defoaming device based on the detection signal obtained in the detection step 101.
Preferably, the defoaming control instruction includes a first defoaming control instruction, a second defoaming control instruction, and a third defoaming control instruction. However, the present invention is not limited thereto, and other defoaming control instructions may be included.
In the defoaming step 103, a corresponding defoaming operation is performed according to the defoaming control instruction.
When the defoaming control instructions are three, the conditions and the corresponding defoaming actions according to each defoaming control instruction will be described in detail below.
Specifically, when the detection signal is a signal which receives only one of the first foam detection unit A1 and the second foam detection unit B1 and the third foam detection unit A2 and the fourth foam detection unit B2, or when the detection signal receives only one of the first foam detection unit A1 and the third foam detection unit A2, or when the detection signal receives only one of the first foam detection unit A1 and the second foam detection unit B1 and the fourth foam detection unit B2, a first defoaming control instruction is sent to the defoaming device,
the defoaming action corresponding to the first defoaming control instruction is not performed and an alarm is sent.
When the detection signals are all four signals received by the first foam detection part A1 and the second foam detection part B1 and the third foam detection part A2 and the fourth foam detection part B2, a second defoaming control instruction is sent to the defoaming device,
the defoaming action corresponding to the second defoaming control instruction is used for defoaming treatment and reducing the rotating speed of the bioreactor or the fermentation tank.
When the detection signal is a signal that receives at least one of the first foam detection portion A1 and the second foam detection portion B1 and the third foam detection portion A2 and the fourth foam detection portion B2, when the first foam control instruction is not sent to the foam apparatus and the second foam control instruction is not sent to the foam apparatus, the third foam control instruction is sent to the foam apparatus,
and defoaming action corresponding to the third defoaming control instruction is used for defoaming treatment.
In addition, the defoaming process performed by the defoaming action corresponding to the third defoaming control instruction may be classified into a plurality of different levels of defoaming process according to the difference of the received detection signals. The defoaming processing is described below in terms of three different classes, but is not limited to this, and may be classified into other suitable classes.
When only signals of the second foam detecting part B1, the third foam detecting part A2 and the fourth foam detecting part B2 are received, the highest-level defoaming treatment is carried out, at the moment, the peristaltic pump operates according to the set rotating speed SP3, and the peristaltic pump operates according to the set pulse action, namely, stops for T3 seconds, operates for T4 seconds, and the T3 plus T4 is 1 period. The cycle of the calculation run is automatically accumulated. When the cycle number exceeds the set cycle, the defoaming process is suspended. At this time, the rotation speed SP3 of the peristaltic pump is the same as that of the peristaltic pump during defoaming processing performed by the defoaming action corresponding to the second defoaming control instruction.
When only the signals of the first foam detecting part A1 and the second foam detecting part B1 are received, advanced defoaming treatment is carried out, at this time, the peristaltic pump operates at a set rotating speed SP2, the rotating speed SP2 is lower than the rotating speed SP3, and other treatments are the same as the highest-stage defoaming treatment.
When only the signals of the second foam detecting part B1 and the third foam detecting part A2 are received, the intermediate defoaming treatment is carried out, at this time, the peristaltic pump operates at a set rotation speed SP1, the rotation speed SP1 is lower than the rotation speed SP2, and the rest treatment is the same as the advanced defoaming treatment.
As described above, the second embodiment can better determine the condition of the foam by adopting the control method matched with the first embodiment. Compared with the prior art, the adding amount of the defoaming agent is more controllable and more accurate, the false alarm and the false action of the device due to the false alarm can be better eliminated, the foam liquid level height can be fully and automatically controlled according to various liquid level shapes, and the risk caused by manual operation is eliminated.
Therefore, according to the full-automatic defoaming control method for the bioreactor or the fermentation tank, the technical problem that defoaming cannot be accurately controlled is solved, the foam height can be fully automatically and accurately controlled, and an unattended function is realized.
Industrial applicability
According to the full-automatic defoaming control device and method for the bioreactor or the fermentation tank, the technical problem that defoaming cannot be accurately controlled is solved, the foam height can be fully automatically and accurately controlled, and an unattended function is realized.
While the invention has been shown and described with reference to certain preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention.
Claims (9)
1. A fully automatic defoaming control apparatus for a bioreactor or a fermenter, comprising:
a first foam detection part and a second foam detection part vertically disposed at the center of the top of the bioreactor or the fermenter;
a third foam detection part and a fourth foam detection part horizontally disposed at an upper side of the bioreactor or the fermenter;
a defoaming device connected with the bioreactor or the fermentation tank and used for defoaming treatment when foam in the bioreactor or the fermentation tank overflows;
a control device for controlling the defoaming device to perform defoaming treatment according to signals from the first foam detection part, the second foam detection part, the third foam detection part and the fourth foam detection part,
the length of the first foam detection part is smaller than that of the second foam detection part and the first foam detection part and the second foam detection part are not connected in the bioreactor or the fermentation tank,
the third foam detection part and the fourth foam detection part have the same length and are positioned higher than the fourth foam detection part in the bioreactor or the fermentation tank.
2. The fully automatic defoaming control apparatus according to claim 1, wherein,
in the bioreactor or the fermentation tank, the end parts of the third foam detection part and the fourth foam detection part are positioned in the middle of the bioreactor or the fermentation tank, the end part of the third foam detection part is lower than the end part of the first foam detection part, and the end part of the second foam detection part is lower than the end part of the fourth foam detection part.
3. The fully automatic defoaming control apparatus according to claim 1, wherein,
the first foam detection portion and the second foam detection portion are detection electrodes.
4. The fully automatic defoaming control apparatus according to claim 1, wherein,
the third foam detection part and the fourth foam detection part are detection electrodes.
5. The fully automatic defoaming control apparatus according to claim 1, wherein,
the defoaming device comprises a peristaltic pump and a valve.
6. A full-automatic defoaming control method of a bioreactor or a fermenter, characterized in that defoaming is performed by using the full-automatic defoaming control apparatus of a bioreactor or a fermenter according to any one of claims 1 to 5, the method comprising the steps of:
a detection step of detecting signals from the first and second and third and fourth foam detection sections;
a control step of sending a defoaming control instruction to the defoaming device according to the detection signal obtained in the detection step;
and defoaming, namely performing corresponding defoaming action according to the defoaming control instruction.
7. The full-automatic defoaming control method according to claim 6, wherein,
the defoaming control instructions include a first defoaming control instruction,
when the detection signal is a signal which only receives any one of the first foam detection part and the second foam detection part and the third foam detection part and the fourth foam detection part, or a signal which only receives the first foam detection part and the third foam detection part, or a signal which only receives the first foam detection part and the second foam detection part and the fourth foam detection part, a first defoaming control instruction is sent to the defoaming device,
the defoaming action corresponding to the first defoaming control instruction is not performed and an alarm is sent.
8. The full-automatic defoaming control method according to claim 7, wherein,
the defoaming control instruction includes a second defoaming control instruction,
when the detection signals are all four signals received by the first foam detection part, the second foam detection part, the third foam detection part and the fourth foam detection part, a second defoaming control instruction is sent to the defoaming device,
the defoaming action corresponding to the second defoaming control instruction is used for defoaming treatment and reducing the rotating speed of the bioreactor or the fermentation tank.
9. The full-automatic defoaming control method according to claim 8, wherein,
the defoaming control instructions include a third defoaming control instruction,
when the detection signal is a signal of receiving at least one of the first foam detection portion and the second foam detection portion and the third foam detection portion and the fourth foam detection portion, when the first defoaming control instruction is not sent to the defoaming device and the second defoaming control instruction is not sent to the defoaming device, the third defoaming control instruction is sent to the defoaming device,
and defoaming action corresponding to the third defoaming control instruction is used for defoaming treatment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310858030.5A CN116676182A (en) | 2023-07-13 | 2023-07-13 | Full-automatic defoaming control device and method for bioreactor or fermentation tank |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310858030.5A CN116676182A (en) | 2023-07-13 | 2023-07-13 | Full-automatic defoaming control device and method for bioreactor or fermentation tank |
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| Publication Number | Publication Date |
|---|---|
| CN116676182A true CN116676182A (en) | 2023-09-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310858030.5A Pending CN116676182A (en) | 2023-07-13 | 2023-07-13 | Full-automatic defoaming control device and method for bioreactor or fermentation tank |
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| Country | Link |
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| CN (1) | CN116676182A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2207458A1 (en) * | 1972-02-17 | 1973-08-30 | Braun Melsungen Ag | Froth detector - including two insulated electrodes with conductive tips |
| EP0156176A1 (en) * | 1984-02-28 | 1985-10-02 | Cetus Corporation | Fermentation control system |
| DD260939A1 (en) * | 1987-06-22 | 1988-10-12 | Adw Ddr | DEVICE FOR MASTERING THE GAME IN THERMAL STERILIZATION IN FERMENTORS |
| US5108655A (en) * | 1989-05-30 | 1992-04-28 | Electro-System, Incorporated | Foam monitoring control system |
| CN200943088Y (en) * | 2006-09-19 | 2007-09-05 | 范茂忠 | Industrial fermentation automatic control flow defoaming agent supplying apparatus |
| US20230125762A1 (en) * | 2020-02-26 | 2023-04-27 | Sartorius Stedim Biotech Gmbh | Detecting foam in a bioreactor plant |
-
2023
- 2023-07-13 CN CN202310858030.5A patent/CN116676182A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2207458A1 (en) * | 1972-02-17 | 1973-08-30 | Braun Melsungen Ag | Froth detector - including two insulated electrodes with conductive tips |
| EP0156176A1 (en) * | 1984-02-28 | 1985-10-02 | Cetus Corporation | Fermentation control system |
| DD260939A1 (en) * | 1987-06-22 | 1988-10-12 | Adw Ddr | DEVICE FOR MASTERING THE GAME IN THERMAL STERILIZATION IN FERMENTORS |
| US5108655A (en) * | 1989-05-30 | 1992-04-28 | Electro-System, Incorporated | Foam monitoring control system |
| CN200943088Y (en) * | 2006-09-19 | 2007-09-05 | 范茂忠 | Industrial fermentation automatic control flow defoaming agent supplying apparatus |
| US20230125762A1 (en) * | 2020-02-26 | 2023-04-27 | Sartorius Stedim Biotech Gmbh | Detecting foam in a bioreactor plant |
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