CN116669688A - 用于护理角蛋白材料的组合物 - Google Patents
用于护理角蛋白材料的组合物 Download PDFInfo
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- CN116669688A CN116669688A CN202080108286.9A CN202080108286A CN116669688A CN 116669688 A CN116669688 A CN 116669688A CN 202080108286 A CN202080108286 A CN 202080108286A CN 116669688 A CN116669688 A CN 116669688A
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- A—HUMAN NECESSITIES
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Abstract
本文提供的是用于护理角蛋白材料的组合物,其包含以下组分、基本上由以下组分组成或由以下组分组成:A)至少两种选自酸性含羟基化合物的双官能抗氧化剂,其也至少用作增白剂;和B)至少两种在室温下是液体的多元醇,其中该多元醇中的至少一种是具有2个或3个羟基的C2‑C6多元醇,其中该组合物是无水的。
Description
技术领域
本发明涉及用于护理角蛋白材料(且特别是皮肤)的化妆品组合物。此外,本发明涉及该化妆品组合物的用途,且特别是作为护肤产品的用途。
背景
化妆品领域的最终目标始终是给予产品皮肤益处,例如水合、保湿、抗衰老、增白、清洁、光滑感觉等等。
随着衰老,皮肤外层(表皮)变薄,即使细胞层数保持不变也如此。然而,含色素细胞(黑素细胞)的数量减少。因此,皮肤显得苍白和半透明。在暴露于阳光的区域中可能出现大的色素斑(老年斑、褐黄斑或雀斑)。结缔组织中的变化降低了皮肤的强度和弹性。这称作弹性组织变性。这在暴露于阳光的区域中更明显(日光性弹性组织变性)。弹性组织变性产生常见于农民、水手和其他在户外花费大量时间的人的皮革样的、饱经风霜的外观。脱水增加了皮肤损伤的风险。营养不良也可对皮肤产生负面影响,引起干燥、皮疹和虚肿。
另一方面,自由基的形成是一种广泛接受的导致皮肤衰老的关键机制。自由基是具有不成对电子的高度反应性分子,其可以直接损害各种细胞膜、脂质、蛋白质、RNA和DNA。这些活性氧物类的损害效应在正常代谢期间在内部被诱导,且通过各种氧化应激在外部被诱导。UV暴露和环境污染可通过在皮肤中产生自由基而加速皮肤衰老。抗氧化剂通过清除自由基并抑制后续氧化反应而保护细胞免遭氧化应激的损害。在护肤产品中广泛使用抗氧化剂的局部施用来防止皮肤衰老。
发明概述
本公开内容涉及组合物和使用该组合物使皮肤获益的方法。该组合物改善皮肤的外观并且为皮肤提供多重抗衰老和其它益处。该组合物的独特性在于其提供具有光滑感觉的强抗氧化功效的能力。
发明人已出乎意料地发现一种无水组合物,其包含组分A)至少两种选自酸性含羟基化合物的双官能抗氧化剂,其也至少用作增白剂;和B)至少两种在室温下是液体的多元醇,其中多元醇中的至少一种是具有2个或3个羟基的C2-C6多元醇。
根据本发明的一种实施方案,相对于组合物的总重量计,组分A)(即,双官能抗氧化剂)的使用量为0.1-40重量%。
根据本发明的组合物特别具有流动且轻盈的质地,适合在安瓿中使用。根据本发明的组合物尤其经时稳定,尤其对抗UV辐射。
本发明的主题还是用于护理或化妆角蛋白材料(特别是皮肤,例如面部)的方法,其包括将根据本发明的组合物局部施用于角蛋白材料。
本发明还涉及根据本发明的组合物用于护理或化妆角蛋白材料、特别用于护理皮肤的用途。根据本发明的组合物特别显示出改善的抗单线态氧效果。因此,根据本发明的组合物(特别是在安瓿产品中使用的情况下),在使皮肤容光焕发和/或光滑滋养皮肤方面优异。
发明的实施方案
贯穿说明书(包括权利要求书),除非另外提及,否则术语“包含/括一种/个”应理解为与“包含/括至少一种/个”同义。此外,本说明书中使用的表述“至少一种/个”等同于表述“一种/个或更多种/个”。
贯穿说明书(包括权利要求书),用“包含/括”等限定的实施方案应理解为涵盖用“基本上由……组成”限定的优选实施方案和用“由......组成”限定的优选实施方案。
优选地,根据本发明的“角蛋白材料”是皮肤。就“皮肤”而言,我们意指所有的身体皮肤。仍优选地,角蛋白材料是面部或颈部,尤其是面部。
就“局部施用”而言,其表示将组合物施用或铺展到角蛋白材料的表面上,例如皮肤的至少一个区域上。
在本申请中,除非另外具体提及,否则含量、份数和百分比按重量基础表示。
除了在操作实施例中或另外指明之处之外,表示组分的量和/或反应条件的所有数值应理解为在所有情况下被术语“约”修饰,具有在本领域中常规知晓的含义,例如在所指出数值的10%内(例如“约10%”表示9%-11%,以及“约2%”表示1.8%-2.2%)。
在本申请中,需要时,用下限和上限定义数值范围,例如给出一个或更多个下限和一个或更多个上限,以形成一个范围(任选连同一个或更多个优选范围)。可通过选择定义给定范围的边界的下限和上限来定义给定范围。以这种方式定义的所有范围是非遍举的且是可组合的,即,任何下限可与任何上限组合以形成一个范围,只要提供下限和上限来修饰同一对象即可。例如,当针对特定对象列举60-110和80-120的范围时,应理解,也考虑并涵盖了范围60-120和80-110。此外,如果列举的下限为1和2,并且将上限列举为3、4和5,则以下范围都是可预测的并且在本公开的范围内:1-3、1-4、1-5、2-3、2-4和2-5。
用于本发明的目的,术语“无水”表示不存在水,或水的存在量使得技术人员可以确定其为不含水或基本上不含水。例如,根据本发明的“无水”组合物相对于该组合物的总重量计可包含少于2重量%、优选少于0.5重量%的水。在适当情况下,如此少量的水可能由包含残余量水的组合物的成分来提供,但并非故意提供。
本发明涉及用于护理角蛋白材料的组合物,其包含以下组分、基本上由以下组分组成或由以下组分组成:
A)至少两种选自酸性含羟基化合物的双官能抗氧化剂,其也至少用作增白剂;和
B)至少两种在室温下是液体的多元醇,其中多元醇中的至少一种是具有2个或3个羟基的C2-C6多元醇,
其中组合物是无水的。
组分A)、双官能抗氧化剂
根据本发明的组合物包含组分A)、至少两种选自酸性含羟基化合物的双官能抗氧化剂,用于本发明的目的,其也至少用作增白剂。
通常,游离羟基相对容易被氧化。因此,含有至少一个羟基的抗氧化剂受高度关注。
双官能抗氧化剂可以是含有羟基的花色素苷。花色素苷和它们的衍生物是抗氧化剂。花色素苷包括一类导致许多果实、蔬菜、谷物和花的红颜色、紫颜色和蓝颜色的类黄酮化合物,其是天然存在的水溶性化合物。另外,花色素苷是胶原酶抑制剂。胶原酶的抑制有助于防止和减少由皮肤胶原减少造成的皱纹、增加皮肤弹性等等。花色素苷可获得自各种植物来源的任何部分,例如果实、花、茎、叶、根、树皮或种子。本领域技术人员将意识到,植物的某些部分可包含较高天然水平的花色素苷,并因此使用这些部分来获得所需花色素苷。在一些情况下,抗氧化剂可包括一种或更多种甜菜碱。甜菜碱类似于花色素苷,可得自天然来源并且是抗氧化剂。
双官能抗氧化剂可以是含有羟基的苯丙素类(肉桂酸的衍生物)。苯丙素类包括:咖啡酸、阿魏酸、反式阿魏酸(包括其抗氧化剂药效团(pharmacore)2,6-二羟基苯乙酮(acetophenome))、5-羟基阿魏酸、芥子酸。在不限制本发明的作用模式的情况下,苯丙素类可中和自由基。
双官能抗氧化剂可以是单宁。有用的单宁包括:单宁、Terflavin B、葡萄糖没食子鞣甙(Glucogallin)、双没食子酸(Dgallic acid)和栎单宁酸。
双官能抗氧化剂可以是含有羟基的有机酸,例如没食子酸、鞣花酸、菊苣酸、绿原酸、迷迭香酸、原儿茶酸或α-羟基酸(例如乳酸和乙醇酸)、及其衍生物、以及以上苯丙素类的类别中列举的酸。
双官能抗氧化剂可以是维生素C或其含有羟基的衍生物,包括抗坏血酸、抗坏血酸钠、抗坏血酸葡糖苷、葡糖胺抗坏血酸盐、抗坏血酸乙酸酯等等。另外,还可能使用得自大量维生素C的植物,例如卡姆果(Myrciaria dubia)、金虎尾(acerola)、余甘子(Emblicaofficinalis)的提取物;以及来自玫瑰果和柑橘的生物类黄酮,包括水溶性生物类黄酮,例如橙皮苷甲基查耳酮。
双官能抗氧化剂的其它实例可包括羟基酪醇芸香苷、芝麻酚、多不饱和脂肪酸和含有羟基的基于硫的抗氧化剂。
不限于任何已知的理论,据信,至少两种上述双官能抗氧化剂的同时使用可以是特别有益的。根据一种实施方案,同时使用的至少两种双官能抗氧化剂中的一种可以是维生素或其衍生物,例如维生素C或其衍生物。例如,可优选维生素C或维生素E,例如维生素C。根据一种实施方案,相对于组合物的总重量计,维生素或其衍生物(如果存在的话)的存在量可以是1-30重量%、优选5-25重量%或7-18重量%。
根据针对同时使用的至少两种双官能抗氧化剂的另一种实施方案,至少两种双官能抗氧化剂中的一种可以是含有羟基的有机酸,例如咖啡酸、阿魏酸、反式阿魏酸、芥子酸、没食子酸、鞣花酸、菊苣酸、绿原酸、迷迭香酸、原儿茶酸、乳酸和/或乙醇酸。例如,可优选阿魏酸、反式阿魏酸和/或鞣花酸,例如阿魏酸。根据一种实施方案,相对于组合物的总重量计,含有羟基的有机酸(如果存在的话)的存在量可以是0.01-20重量%、优选0.1-15重量%或0.5-3重量%。
相对于组合物的总重量计,组分A)的存在量可以是0.01-40重量%、优选0.1-35重量%、1-30重量%或5-20重量%。
组分B)、多元醇
根据本发明的组合物包含多元醇,其在环境温度(25℃)下是液体,优选特别选自特别具有2-20个碳原子(优选具有2-10个碳原子、且更优选具有2-6个碳原子)的多元醇,例如甘油、丙二醇、丁二醇、戊二醇、己二醇、一缩二丙二醇和二甘醇。
优选地,根据本发明的组合物可同时包含至少两种多元醇。根据本发明的一种实施方案,关于同时使用的至少两种多元醇,多元醇中的至少一种是具有2个或3个羟基的C2-C6多元醇。
根据本发明的一种实施方案,关于同时使用的至少两种多元醇,多元醇中的至少两种(优选全部)是低级醇,优选各自具有2-6个碳原子。
根据本发明的一种实施方案,关于同时使用的至少两种多元醇,至少两种多元醇各自包含2个或3个羟基,优选各自具有2-6个碳原子。
根据本发明的示例性实施方案,关于同时使用的至少两种多元醇,多元醇中的至少两种(优选全部)各自为同一烷烃的衍生物。例如,可使用被认为是乙烷的衍生物的乙二醇和二甘醇的组合。再例如,可使用各自被认为是丙烷的衍生物的丙二醇、一缩二丙二醇、甘油和双甘油中的两种、三种或四种的组合。
如上文所提及的,组分A)牵涉至少两种选自酸性含羟基化合物的双官能抗氧化剂,其包含羟基以及任选的羧基。因此,针对有利的溶解和/或稳定性,对同时使用的至少两种多元醇进行特定选择来匹配组分A),尤其匹配其羟基布置。例如,同时使用的至少两种多元醇中的一种多元醇可具有至少两个相邻的羟基,例如乙二醇、1,2-丙二醇或甘油;而同时使用的至少两种多元醇中的另一种多元醇可具有不相邻的羟基,例如1,3-丙二醇;或者甚至尽可能远距离的羟基,例如一缩二丙二醇。
同时使用的至少两种多元醇的实例可以是一缩二丙二醇和甘油的组合;丙二醇、一缩二丙二醇和甘油的组合;以及丙二醇、一缩二丙二醇、甘油和双甘油的组合。
根据本发明的一种实施方案,关于组分B)中同时使用的至少两种多元醇,可按类似的量使用该至少两种多元醇。例如,关于组分B),相对于组分B)的总重量计,同时使用的至少两种多元醇可各自占20-55重量%、优选30-50重量%、或40-50重量%。
相对于组合物的总重量计,组分B)的存在量可以是60-99.99重量%、优选65-99.9重量%、70-99重量%或80-95重量%。
无水形式
用于本发明的目的,根据本发明的组合物基本上呈无水形式。根据本发明,优选避免在组合物中包括水或水分,然而,技术人员容易理解的是,可能未100%去除水。例如,虽然未故意添加水,但是水可能由含有残余量水的组合物的成分来提供,可能在生产期间并入,或可能在生产和/或存储期间从环境中吸收。
因此,用于本发明的目的,术语“无水”表示不存在水,或水的存在量使得技术人员可以确定其为不含水或基本上不含水。例如,根据本发明的“无水”组合物相对于该组合物的总重量计可包含少于2重量%、优选少于0.5重量%的水。优选地,根据本发明的“无水”组合物不包含可检测量的水,其中“可检测量”表示可通过本领域中常规用于测量水含量的设备来检测的量。
任选地,使组分A)和B)、以及任何其它组分(如果存在)在并入本发明的组合物中之前经受去除水的步骤。用于去除水的技术手段不受特别限制,只要所获得的组合物“无水”即可。
另外的抗氧化剂
除了用于组分A)的双官能抗氧化剂以外,根据本发明的组合物还可任选包含与针对根据本发明的组分A)所规定的那些氧化剂不同的另外的抗氧化剂。
所用的另外的抗氧化剂可包括天然外源性植物化学抗氧化剂,例如酚类和类胡萝卜素。
另外的抗氧化剂可包括类黄酮。类黄酮构成超过5,000种通过直接自由基清除而发挥作用的具有抗氧化剂性质的多酚类植物化学成分的一个大类。类黄酮具有抗炎、抗细菌、抗病毒、抗过敏、抗诱变、抗血栓形成、抗肿瘤和血管舒张效果,并且这些作用方法还可以用来防止、减轻或消除来自牙科仪器的氧化损害。类黄酮还展现与金属离子的螯合性质,并且可通过螯合离子来减轻来自金属离子的氧化损害。类黄酮-金属螯合物的形成和稳定性取决于结构的官能团。具有儿茶酚部分并且在5-位置处的羟基与3-位置处的羟基之间具有氢键的类黄酮具有螯合性质。
还可添加芝麻(Sesamum indicum)或木酚素。芝麻及其木酚素(与芝麻相关的纤维状化合物)充当抗氧化剂。芝麻籽木酚素显著增强维生素E活性。
类黄酮可以是黄烷酮(2,3-二氢-2-苯基苯并吡喃-4-酮的衍生物)。黄烷酮包括:黄芩素苷、圣草苷、橙皮素、橙皮苷、sylvestre、异樱花亭、柚皮素、柚皮苷、pinocin、tangrin(枸桔苷)、樱花亭、樱花糖苷和7-O-甲基圣草酚(methyl ergophenol)(Sterubin)。
类黄酮可以是二氢黄酮醇(3-羟基-2,3-二氢-2-苯基苯并吡喃-4-酮的衍生物)。黄烷醇包括:黄杉素(taxifolin)、香橙素、Chrysandroside A、Chrysandroside B、Xeractinol、落新妇苷和黄酮醇。
类黄酮可以是类黄酮(2-苯基苯并吡喃-4-酮的衍生物)。类黄酮包括:芹菜素、木犀草素、柑橘黄酮、白杨黄素、黄芩黄素、野黄芩黄素、汉黄芩素;合成类黄酮:地奥司明和类黄酮酯。
类黄酮可以是黄酮醇(3-羟基-2-苯基苯并吡喃-4-酮的衍生物)。黄酮醇包括:3-羟基黄酮、紫杉色素、槲皮素、高良姜素、棉花皮肤素、山奈酚、山奈酚、异鼠李黄素、桑葚色素、杨梅黄酮、柚皮苷(柚皮黄素)、麝香基(muskyl)黄酮醇(霍香黄酮醇)、槲皮素、甲基rhamnosin、鼠李黄素、杜鹃黄苷、金丝桃苷、异槲皮素、山奈酚、杨梅黄酮、suede糖苷、刺槐素、芸香苷、绣线菊属(Spiraea)、黄鼠李苷、黄柏苷、淫羊藿苷和Tracuridine。
类黄酮可以是黄烷-3-醇(2-苯基-3,4-二氢-2H-苯并吡喃-3-醇的衍生物)。黄烷-3-醇包括:儿茶素、表儿茶素、表没食子儿茶素、表儿茶素没食子酸酯、表没食子儿茶素没食子酸酯、表阿夫儿茶精、非瑟酮醇、Guibourtinidol、牧豆树醇(Mesquitol)和刺槐亭醇。
类黄酮可以是黄烷-4-醇(2-苯基苯并二氢吡喃-4-醇的衍生物)。黄烷-4-醇包括:Apiforol和Luteoforol。
类黄酮可以是异黄酮(3-苯基苯并吡喃-4-酮的衍生物)。异黄酮包括:染料木黄酮、黄豆苷元(daidzein)、garbanin A、芒柄花黄素、和来自黄豆苷元的雌马酚代谢物。
另外的抗氧化剂可以是花色素苷(2-苯基苯并吡喃糖苷阳离子的衍生物)。花色素苷包括:橙凤仙素(Aurantinidin)、矢车菊素、飞燕草素、欧天芥菜色素(Europinidin)、木樨黄定、天竺葵色素(Pelargonidin)、锦葵色素(Malvidin)、Peonyidin(芍药花苷元)、牵牛花色素(矮牵牛苷元)、玫瑰色素(松香色素(Rosinidin))和呫吨酮。
另外的抗氧化剂可以是二氢查耳酮(1,3-二苯基-1-丙酮的衍生物)。二氢查耳酮包括:根皮素、二氢查耳酮根皮苷(phloridin)顺铂、阿司巴汀(Aspalathin)、柚皮苷二氢查耳酮、新橙皮苷二氢查耳酮和Nothofagin。本发明的作用模式不受限,但是二氢查耳酮可通过减少活性自由基(例如活性氧和反应性氮物类)来发挥抗氧化剂作用。
另外的抗氧化剂可以是查耳酮(1,3-二苯基-2-丙烯-1-酮的衍生物)。查耳酮包括:氧化锆、奥卡宁、红花(safflower)、马里苷、广豆根酮、黄腐酚、卡瓦胡椒素(Flavokvain)A、卡瓦胡椒素B、卡瓦胡椒素C和合成索法酮(Safalcone)。
另外的抗氧化剂可以是类姜黄素。类姜黄素包括:姜黄素、去甲氧基姜黄素、双去甲氧基姜黄素、四氢姜黄素和四氢姜黄素。姜黄素和四氢姜黄素可得自姜黄的根茎。已发现四氢姜黄素(姜黄素的代谢物)是比姜黄素更强效的抗氧化剂且更稳定。
另外的抗氧化剂可以是茋类化合物(stilbenoid)。小类(mite)包括:白藜芦醇、紫檀和紫杉醇。白藜芦醇可包括但不限于3,5,4'-三羟基吲哚,3,4,3',5'-四羟基吲哚(cetotriol)、2,3',4,5'-四羟基吲哚(氧化的白藜芦醇),4,4'-二羟基吲哚及其α和β葡糖苷、半乳糖苷和甘露糖苷衍生物。
另外的抗氧化剂可以是香豆素(2H-苯并吡喃-2-酮的衍生物)。香豆素包括:4-羟基香豆素、伞形酮、秦皮乙素、脱肠草素、橙皮油素和双香豆素。
另外的抗氧化剂可以是类胡萝卜素。类胡萝卜素包括:β-胡萝卜素、α-胡萝卜素、γ-胡萝卜素、β-隐黄质、番茄红素、叶黄素和艾地苯醌。
另外的抗氧化剂可以是:呫吨酮、丁基化羟基甲苯、2,6-二叔丁基苯酚、2,4-二甲基-6-叔丁基苯酚、丁子香酚、乙酰半胱氨酸、S-烯丙基半胱氨酸、吡啶酮(Barbigerone)、诃子酸(Chebulagic acid)、依达拉奉、乙氧喹、艾地苯醌、褪黑素、N-乙酰基血清素、去甲二氢愈创木酸、oleotanthal、橄榄苦苷、非洲豆蔻醇(Paradol)、紫杉醇、普罗布考、没食子酸丙酯、羟基吡啶硫酮(pyrithione)、亚麻木酚素二葡糖苷、芝麻素、水飞蓟素、西利马林、茶黄素、茶黄素双没食子酸酯、百里香醌(Thmoquinone)、Trolox、酪醇。
还可以使用芝麻(Sesamum indicum)或芝麻木酚素。芝麻及其木酚素(与芝麻相关的纤维状化合物)充当抗氧化剂。芝麻籽木酚素显著增强维生素E活性。
另外,类胡萝卜素(尤其是叶黄素类型)也是可使用的有用抗氧化剂。叶黄素类型的类胡萝卜素包括诸如叶黄素、角黄素、隐黄质、玉米黄质和虾青素之类的分子。叶黄素化合物保护诸如维生素A、维生素E和其它类胡萝卜素之类的化合物。
根据本发明,相对于本发明的组合物的总重量计,上文描述的另外的抗氧化剂的存在量可以是0.001-10重量%、优选0.1-7重量%或优选0.5-5重量%。
防腐剂
为了使用本发明,根据本发明的组合物可任选包含防腐剂。根据本发明有用的防腐剂可以是常规用于化妆品(尤其用于安瓿产品)的任一种。
例如,根据本发明可使用的防腐剂包括甲基氯异噻唑啉酮、咪唑烷基脲、乙内酰脲的衍生物(例如DMDMH)、对羟基苯甲酸酯、苯氧乙醇、苄醇、氯酚醚、苯甲酸及其盐(例如苯甲酸钠)、山梨酸钾,羟苯乙酮、基于氨基酸的防腐剂、失水山梨糖醇辛酸酯、甘油辛酸酯等等。
根据本发明,相对于本发明组合物的总重量计,防腐剂的存在量可以是0.01-5%、优选0.01%-3%、优选0.01%-1%。
胶凝剂
作为胶凝剂,可提及羧基乙烯基聚合物,例如(卡波姆)和Pemulen,例如Pemulen />和Pemulen />(丙烯酸酯/C10-C30烷基丙烯酸酯共聚物);聚丙烯酰胺,例如由Seppic公司以名称Sepigel/>(CTFA名称:聚丙烯酰胺/C13-14异链烷烃/月桂醇聚醚7)或Simulgel 600(CTFA名称:丙烯酰胺/丙烯酰二甲基牛磺酸钠共聚物/异十六烷/聚山梨酯80)出售的交联共聚物;任选交联和/或中和的2-丙烯酰胺基-2-甲基丙磺酸的聚合物和共聚物,例如由Hoechst以商品名“Hostacerin />”(CTFA名称:聚丙烯酰二甲基牛磺酸铵)出售的多元酸2-丙烯酰胺基-2-甲基丙磺酸或由SEPPIC公司销售的SIMULGEL(CTFA名称:聚丙烯酰二甲基牛磺酸钠/聚山梨酯80/失水山梨糖醇油酸酯);2-丙烯酰胺基-2-甲基丙磺酸和丙烯酸羟乙酯的共聚物,例如由SEPPIC公司销售的SIMULGEL/>和SEPINOV EMT/>纤维素衍生物,例如羟乙基纤维素;多糖且尤其是胶,例如黄原胶、瓜尔胶或角豆胶;水溶性或水分散性硅酮衍生物,例如丙烯酸类硅酮、聚醚硅酮和阳离子硅酮和rs混合物。
在特别优选的实施方案中,根据本发明的组合物包含至少一种任选交联和/或中和的2-丙烯酰胺基-2-甲基丙磺酸聚合物和共聚物,例如聚丙烯酸2-丙烯酰胺基-2-甲基丙磺酸;和或至少一种羧基乙烯基聚合物,例如卡波姆。优选地,根据本发明的组合物包含由Hoechst公司以商品名“Hostacerin ”(CTFA名称:聚丙烯酰二甲基牛磺酸铵)出售的多元酸2-丙烯酰胺基-2-甲基丙磺酸;和至少一种羧基乙烯基聚合物,例如/>(卡波姆)。
相对于根据本发明的组合物的总重量计,胶凝剂在该组合物中的存在量可尤其为0.1重量%-3重量%或特别是0.5重量%-2重量%。
辅剂
按已知的方式,致力于局部施用的剂型还可包含化妆品、制药和/或皮肤病学领域中惯用的辅剂,例如胶凝剂、亲水或亲脂活性剂、香料、填料、过滤剂、pH调节剂、气味吸收剂和染料。这些各种辅剂的量是所考虑领域中常规使用的那些量,并且例如是组合物的总重量的0.01至20%。取决于它们的性质,可将这些辅剂引入水相中。
这些辅剂和它们的浓度必须使得它们不改变本发明组合物的所需性质。
另外的活性成分
根据本发明的组合物可有利地包含一种或更多种另外的活性成分,尤其化妆品、皮肤病学或药物用(活性成分)。
在本发明的上下文中,另外的活性成分是与组合物中存在的组分A)和上文具体定义的其它活性剂不同的活性成分。
有利地,此类化妆品、皮肤病学或药物用的另外的活性成分可旨在对诸如皮肤(包括面部)、头发、睫毛、头皮和/或或皮毛(leather hairy)之类的角蛋白材料(且更优选皮肤)发挥化妆、护理或保健作用。
这种另外的活性成分的选择当然以所讨论的组合物共同寻求的效果为条件。
因此,根据本发明的组合物还可包含具有抗衰老活性或水合活性的活性成分。
当然,本领域技术人员将对按使得根据本发明的组合物所内在附属的有利性质不被或基本上不被所提议的添加改变的方式添加于根据本发明的组合物中的任选另外的活性成分进行小心选择。
相对于组合物的总重量计,这些另外的活性成分通常按以下含量存在于所述组合物中:0.0001重量%-20重量%且优选0.01重量%-10重量%。
可通过在化妆品领域或皮肤病学领域中通常使用的已知方法来制造根据本发明的组合物。
根据本发明的组合物在针对角蛋白材料(例如皮肤、头皮或粘膜(唇部),且更特别是皮肤)的大量处理中(尤其在护理皮肤,滋养皮肤,防止水经表皮损失和/或保护皮肤中)找到其应用。
本发明的主题还是用于护理或化妆角蛋白材料的方法,其包括将如上文定义的组合物施用于角蛋白材料。
尤其,本发明的主题是用于处理干燥和/或粗糙的皮肤的方法,其包括将如上文定义的组合物施用于皮肤。
尤其,本发明的主题是用于处理衰老的皮肤的方法,其包括将如上文定义的组合物施用于皮肤。
本发明还涉及如上文定义的组合物用于护理或化妆角蛋白材料的用途。
在特别实施方案中,组合物适用于处理干燥皮肤。
在特别实施方案中,组合物适用于处理衰老的皮肤。
实施例
以例示且非限制性的方式地给出根据本发明的组合物的以下实施例。以化学名称或INCI名称指明化合物。
除非另外指明,否则下文描述的组合物/配制物中的成分量/浓度以相对于每种组合物/配制物的总重量计的重量%表示。
表1:本发明的实施例1的组合物和比较实施例1-2的组合物
制备以上实例中的组合物的程序简要介绍如下:
1).对所有成分称重并且将它们混合在一起;
2).在80℃的温度下搅拌成分,直至全部溶解;以及
3).冷却至室温。
评估
组合物的稳定性评估。
评估每种组合物的稳定性的程序简要介绍如下:
1)将实施例1的组合物和比较例1的组合物分别装入60ml玻璃瓶,并且分别置于室温以及4℃、37℃和45℃下2个月,以观察在每一温度下的状态;
2)2个月后,取出组合物以达到室温,并且观察组合物的外观、颜色和气味;以及
3)测量已置于45℃下的组合物的活性物含量。
表2:组合物的性能
可见在两个月后,实施例1和比较例1均保留了100%的阿魏酸,然而,关于抗坏血酸,实施例1保留了高达98.4%的抗坏血酸,而比较例1仅保留了80%抗坏血酸。
Claims (16)
1.用于护理角蛋白材料的组合物,其包含以下组分、基本上由以下组分组成或由以下组分组成:
A)至少两种选自酸性含羟基化合物的双官能抗氧化剂,其也至少用作增白剂;和
B)至少两种在室温下是液体的多元醇,其中所述多元醇中的至少一种是具有2个或3个羟基的C2-C6多元醇,
其中所述组合物是无水的。
2.根据权利要求1所述的组合物,其特征在于同时使用的所述至少两种双官能抗氧化剂中的一种是维生素或其衍生物,例如维生素C或其衍生物。
3.根据权利要求2所述的组合物,其特征在于相对于所述组合物的总重量计,所述维生素或其衍生物的存在量为1-30重量%、优选5-25重量%或7-18重量%。
4.根据前述权利要求中任一项所述的组合物,其特征在于所述至少两种双官能抗氧化剂中的一种是含有羟基的有机酸,例如咖啡酸、阿魏酸、反式阿魏酸、芥子酸、没食子酸、鞣花酸、菊苣酸、绿原酸、迷迭香酸、原儿茶酸、乳酸和/或乙醇酸。
5.根据权利要求4所述的组合物,其特征在于相对于所述组合物的总重量计,所述含有羟基的有机酸的存在量为0.01-20重量%、优选0.1-15重量%或0.5-3重量%。
6.根据前述权利要求中任一项所述的组合物,其特征在于相对于所述组合物的总重量计,所述组分A)的存在量为0.01-40重量%、优选0.1-35重量%、1-30重量%或5-20重量%。
7.根据前述权利要求中任一项所述的组合物,其特征在于所述组分B)选自具有2-20个碳原子、优选具有2-10个碳原子、且优选具有2-6个碳原子的多元醇,例如甘油、丙二醇、丁二醇、戊二醇、己二醇、一缩二丙二醇和/或二甘醇。
8.根据前述权利要求中任一项所述的组合物,其特征在于所述多元醇中的至少两种、优选全部是低级醇,优选各自具有2-6个碳原子。
9.根据前述权利要求中任一项所述的组合物,其特征在于至少两种多元醇各自包含2个或3个羟基。
10.根据前述权利要求中任一项所述的组合物,其特征在于对于所述组分B),同时使用的所述至少两种多元醇中的一种多元醇可具有至少两个相邻的羟基,例如乙二醇、1,2-丙二醇或甘油;而同时使用的所述至少两种多元醇中的另一种多元醇可具有不相邻的羟基,例如1,3-丙二醇,或者甚至尽可能远距离的羟基,例如一缩二丙二醇。
11.根据前述权利要求中任一项所述的组合物,其特征在于相对于所述组合物的总重量计,所述组分B)的存在量为60-99.99重量%、优选65-99.9重量%、70-99重量%或80-95重量%。
12.根据前述权利要求中任一项所述的组合物,其特征在于相对于所述组合物的总重量计,所述组合物包含少于2重量%、优选少于0.5重量%的水。
13.根据前述权利要求中任一项所述的组合物,其特征在于所述组合物包含选自以下的另外的抗氧化剂:天然外源性植物化学抗氧化剂、类黄酮、类胡萝卜素、二氢查耳酮、查耳酮、类姜黄素、茋类化合物、香豆素、类胡萝卜素、或其混合物。
14.根据前述权利要求中任一项所述的组合物,其特征在于相对于本发明组合物的总重量计,所述另外的抗氧化剂的使用量为0.001-10重量%、优选0.1-7重量%或优选0.5-4重量%。
15.根据前述权利要求中任一项所述的组合物用于护理角蛋白材料、尤其在皮肤上局部施用的用途。
16.用于护理或化妆角蛋白材料的方法,其包括将根据权利要求1-14中任一项所述的组合物施用于所述角蛋白材料。
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US20100040696A1 (en) * | 2008-08-12 | 2010-02-18 | Ilse Sente | Composite Particles Having An Antioxidant-Based Protective System, And Topical Compositions Comprising The Same |
FR2940615B1 (fr) * | 2008-12-30 | 2011-12-30 | Oreal | Association de monosaccharides avec des agents antioxydants et son utilisation en cosmetique |
FR2954144B1 (fr) * | 2009-12-18 | 2012-01-27 | Oreal | Utilisation d'un polymere a titre d'agent antioxydant |
WO2018209117A1 (en) * | 2017-05-12 | 2018-11-15 | Shaklee Corporation | Topical muscadine formulation for cosmetic use |
FR3088548B1 (fr) * | 2018-11-15 | 2021-01-22 | Oreal | Composition comprenant un derive d’acide cinnamique et un polymere cellulosique non ionique non associatif |
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CN105407720A (zh) * | 2012-10-12 | 2016-03-16 | 莱雅公司 | 含有至少一种类黄酮和阿魏酸的化妆品组合物 |
WO2017172519A1 (en) * | 2016-03-31 | 2017-10-05 | L'oreal | Photo-stabilized compositions and methods of use |
US10137072B2 (en) * | 2016-03-31 | 2018-11-27 | L'oreal | Methods and compositions for providing broad spectrum photo protection using antioxidants |
WO2018081790A1 (en) * | 2016-10-31 | 2018-05-03 | L'oreal | Compositions containing phenolic compounds having synergistic antioxidant benefits |
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