CN116635393A - 中环或大环苄基取代的杂环衍生物及其作为食欲素-2受体激动剂的用途 - Google Patents
中环或大环苄基取代的杂环衍生物及其作为食欲素-2受体激动剂的用途 Download PDFInfo
- Publication number
- CN116635393A CN116635393A CN202180074185.9A CN202180074185A CN116635393A CN 116635393 A CN116635393 A CN 116635393A CN 202180074185 A CN202180074185 A CN 202180074185A CN 116635393 A CN116635393 A CN 116635393A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- compound
- alkenyl
- certain embodiments
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063074220P | 2020-09-03 | 2020-09-03 | |
| US63/074220 | 2020-09-03 | ||
| PCT/US2021/049003 WO2022051583A1 (en) | 2020-09-03 | 2021-09-03 | Medium- or macro-cyclic benzyl-substituted heterocycle derivatives and their uses as orexin-2 receptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116635393A true CN116635393A (zh) | 2023-08-22 |
Family
ID=78078371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180074185.9A Pending CN116635393A (zh) | 2020-09-03 | 2021-09-03 | 中环或大环苄基取代的杂环衍生物及其作为食欲素-2受体激动剂的用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230331720A1 (https=) |
| EP (1) | EP4208465A1 (https=) |
| JP (1) | JP7811578B2 (https=) |
| CN (1) | CN116635393A (https=) |
| TW (1) | TW202227433A (https=) |
| WO (1) | WO2022051583A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI4065585T3 (fi) | 2019-11-25 | 2025-09-26 | Alkermes Inc | Substituoituja makrosyklisiä yhdisteitä ja niihin liittyviä hoitomenetelmiä |
| US12503475B2 (en) | 2020-09-03 | 2025-12-23 | Centessa Pharmaceuticals (Uk) Limited | Bicyclic-heterocycle derivatives and their uses as orexin-2 receptor agonists |
| US12006330B2 (en) | 2020-12-21 | 2024-06-11 | Alkermes, Inc. | Substituted macrocyclic compounds and related methods of treatment |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| WO2022251304A1 (en) * | 2021-05-26 | 2022-12-01 | Alkerme, Inc. | Substituted carbamate macrocyclic compounds and related methods of treatment |
| KR20240157067A (ko) * | 2022-03-01 | 2024-10-31 | 센테사 파마슈티칼스 (유케이) 리미티드 | 미디엄- 또는 마크로-시클릭 벤질-치환된 헤테로사이클 유도체 및 관련 용도 |
| CN119677753A (zh) * | 2022-04-22 | 2025-03-21 | 帝人制药株式会社 | 氧杂氮杂环庚三烯衍生物 |
| CN114716319B (zh) * | 2022-04-28 | 2024-03-26 | 浙江工业大学 | 一种联芳氧基烯酸酯类化合物的合成方法 |
| AR130709A1 (es) * | 2022-10-07 | 2025-01-08 | Kissei Pharmaceutical | Compuesto de ciclopentano |
| WO2024095158A1 (en) | 2022-10-31 | 2024-05-10 | Takeda Pharmaceutical Company Limited | Dosing of orexin type 2 receptor agonists |
| KR20250155550A (ko) | 2023-03-16 | 2025-10-30 | 다케다 야쿠힌 고교 가부시키가이샤 | 매크로시클릭 헤테로시클 화합물 및 이의 용도 |
| US20240425521A1 (en) | 2023-06-01 | 2024-12-26 | H. Lundbeck A/S | Spiromacrocyclic orexin 2 receptor agonists |
| TW202502342A (zh) | 2023-06-02 | 2025-01-16 | 日商武田藥品工業股份有限公司 | 食慾素２受體促效劑用於改善睡眠期間之呼吸功能的用途 |
| TW202535890A (zh) * | 2023-10-20 | 2025-09-16 | 日商帝人製藥股份有限公司 | 氧氮呯衍生物之結晶或其溶劑合物之結晶 |
| WO2025124698A1 (en) | 2023-12-12 | 2025-06-19 | Idorsia Pharmaceuticals Ltd | Aryl sulfone and sulfanone derivatives as orexin receptor modulators |
| TW202542165A (zh) | 2023-12-19 | 2025-11-01 | 瑞士商愛杜西亞製藥有限公司 | 大環食慾素激動劑 |
| WO2025229493A1 (en) | 2024-04-29 | 2025-11-06 | Takeda Pharmaceutical Company Limited | Dosing of orexin type 2 receptor agonists |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101880276A (zh) * | 2006-12-01 | 2010-11-10 | 默沙东公司 | 作为食欲素受体拮抗剂的取代的二氮杂环庚烷化合物 |
| CN111051295A (zh) * | 2017-08-03 | 2020-04-21 | 武田药品工业株式会社 | 杂环化合物及其用途 |
| WO2020158958A1 (en) * | 2019-01-31 | 2020-08-06 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5763263A (en) | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
| FI4065585T3 (fi) * | 2019-11-25 | 2025-09-26 | Alkermes Inc | Substituoituja makrosyklisiä yhdisteitä ja niihin liittyviä hoitomenetelmiä |
-
2021
- 2021-09-03 WO PCT/US2021/049003 patent/WO2022051583A1/en not_active Ceased
- 2021-09-03 CN CN202180074185.9A patent/CN116635393A/zh active Pending
- 2021-09-03 US US18/024,236 patent/US20230331720A1/en active Pending
- 2021-09-03 JP JP2023515095A patent/JP7811578B2/ja active Active
- 2021-09-03 TW TW110132882A patent/TW202227433A/zh unknown
- 2021-09-03 EP EP21786656.5A patent/EP4208465A1/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101880276A (zh) * | 2006-12-01 | 2010-11-10 | 默沙东公司 | 作为食欲素受体拮抗剂的取代的二氮杂环庚烷化合物 |
| CN111051295A (zh) * | 2017-08-03 | 2020-04-21 | 武田药品工业株式会社 | 杂环化合物及其用途 |
| WO2020158958A1 (en) * | 2019-01-31 | 2020-08-06 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
Non-Patent Citations (1)
| Title |
|---|
| 杨妙;邓康;: "食欲素受体拮抗剂的研究进展", 天津药学, no. 05, 28 October 2017 (2017-10-28), pages 69 - 73 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023540350A (ja) | 2023-09-22 |
| WO2022051583A1 (en) | 2022-03-10 |
| JP7811578B2 (ja) | 2026-02-05 |
| TW202227433A (zh) | 2022-07-16 |
| EP4208465A1 (en) | 2023-07-12 |
| US20230331720A1 (en) | 2023-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: Cheshire Applicant after: Sentesa Pharmaceuticals (Oresa) Co.,Ltd. Address before: London Applicant before: Ouruixia Treatment Co.,Ltd. |
|
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20240218 Address after: Cheshire Applicant after: Sentesa Pharmaceuticals (UK) Ltd. Country or region after: United Kingdom Address before: Cheshire Applicant before: Sentesa Pharmaceuticals (Oresa) Co.,Ltd. Country or region before: United Kingdom |