CN116635390B - 作为血清素1b受体调节剂的强效和选择性化合物 - Google Patents
作为血清素1b受体调节剂的强效和选择性化合物Info
- Publication number
- CN116635390B CN116635390B CN202180068969.0A CN202180068969A CN116635390B CN 116635390 B CN116635390 B CN 116635390B CN 202180068969 A CN202180068969 A CN 202180068969A CN 116635390 B CN116635390 B CN 116635390B
- Authority
- CN
- China
- Prior art keywords
- methyl
- oxadiazol
- dimethylamino
- ethoxy
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20382888.4 | 2020-10-08 | ||
| EP20382888 | 2020-10-08 | ||
| PCT/EP2021/077660 WO2022074103A1 (en) | 2020-10-08 | 2021-10-07 | Potent and selctive compounds as serotonin 1b receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116635390A CN116635390A (zh) | 2023-08-22 |
| CN116635390B true CN116635390B (zh) | 2026-03-27 |
Family
ID=73030029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180068969.0A Active CN116635390B (zh) | 2020-10-08 | 2021-10-07 | 作为血清素1b受体调节剂的强效和选择性化合物 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US12540133B2 (https=) |
| EP (2) | EP4445901A3 (https=) |
| JP (1) | JP7687636B2 (https=) |
| KR (1) | KR20230107566A (https=) |
| CN (1) | CN116635390B (https=) |
| AU (1) | AU2021356114A1 (https=) |
| CA (1) | CA3194700A1 (https=) |
| CL (1) | CL2023001021A1 (https=) |
| DK (1) | DK4225753T3 (https=) |
| ES (1) | ES2985416T3 (https=) |
| FI (1) | FI4225753T3 (https=) |
| HR (1) | HRP20241184T1 (https=) |
| HU (1) | HUE068199T2 (https=) |
| IL (1) | IL301806B1 (https=) |
| LT (1) | LT4225753T (https=) |
| MX (1) | MX2023004116A (https=) |
| PL (1) | PL4225753T3 (https=) |
| PT (1) | PT4225753T (https=) |
| RS (1) | RS65956B1 (https=) |
| SI (1) | SI4225753T1 (https=) |
| WO (1) | WO2022074103A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR123701A1 (es) | 2020-10-08 | 2023-01-04 | Merck Sharp & Dohme | Preparación de derivados de oxindol como nuevos inhibidores de la diacilglicerol o-aciltransferasa 2 |
| EP4382519A4 (en) * | 2021-08-27 | 2024-12-04 | Adlai Nortye Biopharma Co., Ltd. | CYCLIN K DEGRADING AGENT |
| AU2024302643A1 (en) | 2023-06-16 | 2026-01-22 | Leukos Biotech Sl | 5-htr1b modulator for use in the treatment of solid tumours |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1094037A (zh) * | 1992-12-30 | 1994-10-26 | 格拉克索公司 | N-苯甲酰苯胺衍生物 |
| WO2007077457A2 (en) * | 2006-01-06 | 2007-07-12 | The Royal Veterinary College | Treatment of equine laminitis with 5-ht1b/ 1d antagonists |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5801170A (en) | 1993-12-07 | 1998-09-01 | Smithkline Beecham Plc | Heterocyclic biphenylylamides useful as 5HT1D antagonists |
| ZA985542B (en) * | 1997-07-03 | 1999-04-07 | Smithkline Beecham Corp | Substituted benzanilides as CCR5 receptor ligands antiinflammatory agents and antiviral agents |
| EP1098892A1 (en) | 1998-07-20 | 2001-05-16 | MERCK PATENT GmbH | Biphenyl derivatives |
| BR0112856A (pt) | 2000-07-31 | 2003-07-01 | Smithkline Beecham Plc | Método para o tratamento dos distúrbios, composto ou um sal ou solvato deste, processo para a preparação dos mesmos, composição farmacêutico, método de tratamento e/ou profilaxia de um ou mais dos distúrbios, uso de um composto, e, método para o tratamento de diabetes, grande depressão, depressão manìaca, ansiedade, esquizofrenia e distúrbios do sono, em mamìferos humanos e não humanos |
| US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
| WO2007057742A2 (en) | 2005-11-18 | 2007-05-24 | Pfizer Products Inc. | Novel piperazinone derivatives |
| EP3348266A1 (en) | 2017-01-16 | 2018-07-18 | Leukos Biotech, S.L. | Combination therapy for treating cancer |
-
2021
- 2021-10-07 FI FIEP21789678.6T patent/FI4225753T3/fi active
- 2021-10-07 DK DK21789678.6T patent/DK4225753T3/da active
- 2021-10-07 PL PL21789678.6T patent/PL4225753T3/pl unknown
- 2021-10-07 US US18/248,393 patent/US12540133B2/en active Active
- 2021-10-07 KR KR1020237015543A patent/KR20230107566A/ko active Pending
- 2021-10-07 HR HRP20241184TT patent/HRP20241184T1/hr unknown
- 2021-10-07 CN CN202180068969.0A patent/CN116635390B/zh active Active
- 2021-10-07 CA CA3194700A patent/CA3194700A1/en active Pending
- 2021-10-07 LT LTEPPCT/EP2021/077660T patent/LT4225753T/lt unknown
- 2021-10-07 IL IL301806A patent/IL301806B1/en unknown
- 2021-10-07 ES ES21789678T patent/ES2985416T3/es active Active
- 2021-10-07 PT PT217896786T patent/PT4225753T/pt unknown
- 2021-10-07 WO PCT/EP2021/077660 patent/WO2022074103A1/en not_active Ceased
- 2021-10-07 EP EP24191411.8A patent/EP4445901A3/en not_active Withdrawn
- 2021-10-07 RS RS20240938A patent/RS65956B1/sr unknown
- 2021-10-07 JP JP2023522401A patent/JP7687636B2/ja active Active
- 2021-10-07 AU AU2021356114A patent/AU2021356114A1/en active Pending
- 2021-10-07 SI SI202130183T patent/SI4225753T1/sl unknown
- 2021-10-07 MX MX2023004116A patent/MX2023004116A/es unknown
- 2021-10-07 HU HUE21789678A patent/HUE068199T2/hu unknown
- 2021-10-07 EP EP21789678.6A patent/EP4225753B1/en active Active
-
2023
- 2023-04-06 CL CL2023001021A patent/CL2023001021A1/es unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1094037A (zh) * | 1992-12-30 | 1994-10-26 | 格拉克索公司 | N-苯甲酰苯胺衍生物 |
| WO2007077457A2 (en) * | 2006-01-06 | 2007-07-12 | The Royal Veterinary College | Treatment of equine laminitis with 5-ht1b/ 1d antagonists |
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20241184T1 (hr) | 2024-11-22 |
| DK4225753T3 (da) | 2024-08-19 |
| WO2022074103A1 (en) | 2022-04-14 |
| JP7687636B2 (ja) | 2025-06-03 |
| MX2023004116A (es) | 2023-06-13 |
| EP4225753A1 (en) | 2023-08-16 |
| CN116635390A (zh) | 2023-08-22 |
| RS65956B1 (sr) | 2024-10-31 |
| CL2023001021A1 (es) | 2023-11-24 |
| US20240166639A1 (en) | 2024-05-23 |
| LT4225753T (lt) | 2024-08-26 |
| JP2023547346A (ja) | 2023-11-10 |
| IL301806B1 (en) | 2026-01-01 |
| EP4445901A2 (en) | 2024-10-16 |
| AU2021356114A1 (en) | 2023-05-18 |
| AU2021356114A9 (en) | 2024-09-12 |
| HUE068199T2 (hu) | 2024-12-28 |
| SI4225753T1 (sl) | 2024-10-30 |
| PT4225753T (pt) | 2024-08-30 |
| EP4225753B1 (en) | 2024-07-31 |
| FI4225753T3 (fi) | 2024-08-29 |
| KR20230107566A (ko) | 2023-07-17 |
| PL4225753T3 (pl) | 2024-11-18 |
| US12540133B2 (en) | 2026-02-03 |
| EP4445901A3 (en) | 2024-12-04 |
| IL301806A (en) | 2023-05-01 |
| ES2985416T3 (es) | 2024-11-05 |
| CA3194700A1 (en) | 2022-04-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: Barcelona, Spain Patentee after: Lecos Biotechnology Co.,Ltd. Country or region after: Spain Patentee after: Josep Carreras Leukemia Research Foundation Address before: Barcelona, Spain Patentee before: Lexus Biotechnology Country or region before: Spain Patentee before: Josep Carreras Leukemia Research Foundation |