CN116615435A - 制备脂质肽的方法 - Google Patents

制备脂质肽的方法 Download PDF

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Publication number
CN116615435A
CN116615435A CN202180086210.5A CN202180086210A CN116615435A CN 116615435 A CN116615435 A CN 116615435A CN 202180086210 A CN202180086210 A CN 202180086210A CN 116615435 A CN116615435 A CN 116615435A
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CN
China
Prior art keywords
group
gly
carbon atoms
formula
compound represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180086210.5A
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English (en)
Chinese (zh)
Inventor
庄子武明
山口大希
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Original Assignee
Nissan Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp filed Critical Nissan Chemical Corp
Publication of CN116615435A publication Critical patent/CN116615435A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
CN202180086210.5A 2020-12-25 2021-12-24 制备脂质肽的方法 Pending CN116615435A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020217822 2020-12-25
JP2020-217822 2020-12-25
PCT/JP2021/048380 WO2022138957A1 (ja) 2020-12-25 2021-12-24 脂質ペプチドの製造方法

Publications (1)

Publication Number Publication Date
CN116615435A true CN116615435A (zh) 2023-08-18

Family

ID=82158253

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180086210.5A Pending CN116615435A (zh) 2020-12-25 2021-12-24 制备脂质肽的方法

Country Status (5)

Country Link
US (1) US20240116979A1 (https=)
JP (1) JPWO2022138957A1 (https=)
CN (1) CN116615435A (https=)
TW (1) TW202241919A (https=)
WO (1) WO2022138957A1 (https=)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1184770C2 (de) * 1961-06-01 1965-09-02 Hoffmann La Roche Verfahren zur Herstellung von antibacteriell wirksamen Peptiden
CN102596986B (zh) * 2009-09-07 2015-08-05 日产化学工业株式会社 脂质肽化合物的制造方法
WO2022138953A1 (ja) * 2020-12-25 2022-06-30 日産化学株式会社 脂質ペプチドの製造方法

Also Published As

Publication number Publication date
TW202241919A (zh) 2022-11-01
US20240116979A1 (en) 2024-04-11
JPWO2022138957A1 (https=) 2022-06-30
WO2022138957A1 (ja) 2022-06-30

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