CN116550404A - Microfluidic chip fixture and microfluidic chip - Google Patents

Microfluidic chip fixture and microfluidic chip Download PDF

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Publication number
CN116550404A
CN116550404A CN202310615191.1A CN202310615191A CN116550404A CN 116550404 A CN116550404 A CN 116550404A CN 202310615191 A CN202310615191 A CN 202310615191A CN 116550404 A CN116550404 A CN 116550404A
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CN
China
Prior art keywords
clamping plate
microfluidic chip
turnover
groove
rod body
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CN202310615191.1A
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Chinese (zh)
Inventor
请求不公布姓名
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Shanghai Weiran Technology Co ltd
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Shanghai Weiran Technology Co ltd
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Priority to CN202310615191.1A priority Critical patent/CN116550404A/en
Publication of CN116550404A publication Critical patent/CN116550404A/en
Pending legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Measuring Leads Or Probes (AREA)

Abstract

The application provides a microfluidic chip clamp and a microfluidic chip, and relates to the technical field of microfluidic chips, and the microfluidic chip clamp comprises a fixed clamping plate and a turnover clamping plate, wherein the turnover clamping plate is rotationally connected with the fixed clamping plate; the fixed clamping plate is provided with a groove, two sides of the groove are respectively provided with a positioning piece and a reference side, and the positioning pieces are used for propping the microfluidic chip against the reference side; the turnover clamping plate is provided with a clamp assembly and a first probe assembly; when the overturning clamping plate is buckled with the fixing clamping plate and the microfluidic chip is abutted against the reference side, the first probe assembly is matched with the electrode and realizes circuit connection, and two ends of the clamping hoop assembly are respectively used for connecting a liquid inlet pipe and a liquid inlet on the microfluidic chip so as to realize liquid conveying; the turnover clamping plate or the fixing clamping plate is provided with a locking mechanism which is used for locking the turnover clamping plate and the fixing clamping plate which are in a buckling state. The groove, the reference side and the positioning piece are arranged, so that the fixation, the sealing and the circuit conduction of the microfluidic chip can be realized conveniently and reliably.

Description

Microfluidic chip fixture and microfluidic chip
Technical Field
The application relates to the technical field of microfluidic chips, in particular to a microfluidic chip clamp and a microfluidic chip.
Background
Microfluidic chip technology is a technology that integrates multiple basic operation units of sample preparation, reaction, separation, detection, etc. in biological, chemical, and medical analysis processes onto one micron-scale chip.
In the application process of the microfluidic chip, the microfluidic chip needs to be matched with a corresponding clamp for use, and the clamp not only can play a role in fixing the microfluidic chip, but also needs to have good expansibility and sealing property.
The existing microfluidic chip clamp at present has the following problems: 1. the clamp which uses the screw and the nut for locking is troublesome to assemble and disassemble, and the pretightening force aiming at the micro-fluidic chip is not well controlled; 2. the clamp locked by using the gluing mode cannot be disassembled, and subsequent operation is inconvenient.
Disclosure of Invention
In view of this, the embodiments of the present disclosure provide a microfluidic chip fixture and a microfluidic chip, which can conveniently and reliably fix, seal and conduct a circuit to the microfluidic chip.
The embodiment of the specification provides the following technical scheme:
the embodiment of the specification provides a microfluidic chip clamp, which comprises a fixed clamping plate and a turnover clamping plate which can be mutually buckled, wherein the turnover clamping plate is rotationally connected with the fixed clamping plate;
the fixing clamp plate is provided with a groove for placing the microfluidic chip, one side of the groove is provided with a positioning piece, one side of the groove away from the positioning piece is a reference side, and the positioning piece is used for propping the microfluidic chip placed in the groove against the reference side;
the turnover clamping plate is provided with a clamp assembly and a first probe assembly;
when the turnover clamping plate is buckled with the fixed clamping plate through rotation and the positioning piece supports the microfluidic chip against the reference side, the first probe assembly is matched with an electrode on the microfluidic chip and is connected with a circuit, one end of the clamp assembly is used for being connected with a liquid inlet pipe, and the other end of the clamp assembly is used for being connected with a liquid inlet on the microfluidic chip to realize liquid conveying of the microfluidic chip;
the turnover clamping plate or the fixing clamping plate is provided with a locking mechanism, and the locking mechanism is used for locking the turnover clamping plate and the fixing clamping plate which are in a buckling state.
Through the technical scheme, after the groove, the reference side and the locating piece are arranged, the position of the microfluidic chip can be determined by propping the microfluidic chip against the reference side in the groove through the locating piece, then the microfluidic chip is fixed in the groove in a clamping mode by matching with the overturning clamping plate and the fixing clamping plate, and when the microfluidic chip is fixed, the first probe assembly is matched with the electrode, so that circuit conduction is realized, the liquid is conveyed through the clamp assembly connecting liquid inlet pipe and the liquid inlet, the sealing of the microfluidic chip is realized, the overall structure is high in reliability, convenient to operate and simple in structure, and better maintainability is realized.
Preferably, the surface of the turnover clamping plate, which is used for being buckled with the fixed clamping plate, is provided with a binding part;
the first probe assembly is arranged on the surface of the attaching part far away from the overturning clamping plate;
when the turnover clamping plate is buckled with the fixed clamping plate through rotation and the positioning piece supports the microfluidic chip on the reference side, the surface of the attaching part, which is away from the turnover clamping plate, is attached to the surface of the microfluidic chip in the groove, and the first probe assembly is matched with an electrode on the microfluidic chip and is connected with a circuit.
Preferably, a second probe assembly is arranged on the surface of the turnover clamping plate, which is used for being buckled with the fixed clamping plate, a contact assembly is arranged on the surface of the fixed clamping plate, which is used for being buckled with the turnover clamping plate, and the second probe assembly and the first probe assembly are connected in series;
when the turnover clamping plate is buckled with the fixing clamping plate through rotation and the positioning piece supports the microfluidic chip on the reference side, the second probe assembly is matched with the contact assembly, and the first probe assembly is matched with an electrode on the microfluidic chip, so that circuit connection among the first probe assembly, the electrode on the microfluidic chip, the second probe assembly and the contact assembly is realized.
Through above-mentioned technical scheme, set up second probe subassembly and contact subassembly for second probe subassembly and first probe subassembly establish ties and set up, and then when actually setting up the wire, only need connect the wire alone in fixed splint one side and can realize the switch-on of circuit, because wire unilateral setting, consequently the wire can not appear the condition of buckling because of the lock of upset splint and fixed splint, and the reliability of circular telegram use is higher.
Preferably, the first probe assembly and the second probe assembly are each comprised of a plurality of resilient probes.
Through above-mentioned technical scheme, set up the elasticity probe, ensure that all contacts can all be contacted simultaneously, guarantee that the circuit is put through.
Preferably, the contact assembly is composed of a plurality of contacts;
the periphery of the contact and the periphery of the elastic probe are both provided with insulating sleeves.
Through above-mentioned technical scheme, set up insulating cover, guarantee the insulating nature to avoid leaking the emergence of electric phenomenon.
Preferably, the turnover clamping plate is provided with a mounting hole, and the locking mechanism comprises a locking spring and a locking rod penetrating through the mounting hole;
the locking rod comprises a rod body, a clamping part and a lifting part, wherein the clamping part and the lifting part are respectively positioned at two ends of the rod body, the rod body is arranged in the mounting hole in a penetrating mode, the axis of the rod body is perpendicular to the overturning clamping plate, the clamping part is positioned at one end, close to the fixed clamping plate, of the rod body, the lifting part is positioned at one end, far away from the fixed clamping plate, of the rod body, and the rod body is adjustable relative to the overturning clamping plate along the axis direction;
one end of the locking spring is fixedly connected with the overturning clamping plate, and the other end of the locking spring is fixedly connected with the lifting part;
when the overturning clamping plate is buckled with the fixed clamping plate, the locking spring drives the lifting part to move away from the overturning clamping plate, so that the clamping part is abutted against one end of the fixed clamping plate, which is away from the overturning clamping plate.
Through above-mentioned technical scheme, during in-service use, only need promote and carry and draw the portion for clamping part moves towards the direction of keeping away from the upset splint earlier, waits that fixed splint deviates from the one end of upset splint, gets into after between clamping part and the upset splint, loosens again and carries and draw the portion, relies on locking spring's effort, can accomplish the lock locking between fixed splint and the upset splint, convenient to use is swift, and also is favorable to subsequent dismantlement.
Preferably, the rod body can rotate in the mounting hole around the axis, and the fixed clamping plate is provided with a locking clamping groove for the clamping part to pass through;
when the overturning clamping plate is buckled with the fixed clamping plate, the clamping part is locked in the clamping groove and rotated by a fixed angle, and under the action of the locking spring, the two ends of the clamping part are abutted against the end face of the fixed clamping plate, which is away from the overturning clamping plate.
Preferably, a plurality of positioning grooves are formed in the circumferential side wall of the rod body, and the positioning grooves are uniformly distributed in the circumferential direction on the rod body;
the turnover clamping plate is connected with a spring plunger in a sliding manner, the sliding direction of the spring plunger is perpendicular to the axial direction of the rod body, and one end of the spring plunger is propped against the peripheral wall of the rod body or the bottom of the positioning groove;
the spring plunger makes sliding movement relative to the overturning clamping plate along the axial direction when the rod body rotates, and when the spring plunger moves into the other adjacent positioning groove from one positioning groove, the rod body drives the clamping part to rotate for a fixed angle.
Through above-mentioned technical scheme, set up the spring plunger, the spring plunger can play the positioning action when the body of rod is rotatory, as long as the spring plunger gets into in the constant head tank, indicate the body of rod rotation in place promptly, also can play the effect of reminding operating personnel.
Preferably, a first rotating connecting block is arranged on the fixed clamping plate, and a second rotating connecting block is arranged on the turnover clamping plate;
the middle area of the first rotating connecting block is provided with a rotating connecting groove, the middle area of the second rotating connecting block is provided with a rotating connecting part matched with the rotating connecting groove, and the rotating connecting part stretches into the rotating connecting groove and is in rotating connection with the rotating connecting groove;
rolling grooves are respectively formed in two ends of the rotating connecting part, steel balls are arranged in the rolling grooves, bearings are respectively arranged on two sides of the rotating connecting part, the steel balls at two ends of the rotating connecting part are respectively abutted to the bearings on two sides of the rotating connecting part, and the steel balls and the bearings are coaxially arranged;
the second rotating connecting block is further provided with two jackscrews, and the two jackscrews are respectively abutted against the two steel balls, so that the two steel balls are respectively in rolling friction with the two bearings.
Through above-mentioned technical scheme, set up steel ball, bearing and jackscrew, form the rolling friction between steel ball and the bearing for the location of upset splint relative to fixed splint rotation in-process is more accurate, reduces rocking between upset splint and the fixed splint, makes laminating between upset splint and the fixed splint inseparabler.
The embodiment of the specification also provides a microfluidic chip, which comprises a chip body, wherein the size and the electrode distribution of the chip body are adapted to any one of the microfluidic chip clamps.
Through the technical scheme, the fixation, sealing and circuit conduction of the micro-fluidic chip can be realized conveniently and reliably.
Compared with the prior art, the beneficial effects that above-mentioned at least one technical scheme that this description embodiment adopted can reach include at least:
1. through setting up recess, benchmark side and setting element, make the position of micro-fluidic chip after loading into recess, can be through setting element will micro-fluidic chip in recess lean on benchmark side to confirm, cooperate upset splint and fixed splint again, fix micro-fluidic chip in recess with the form of centre gripping;
2. by arranging the first probe assembly to be matched with the electrode, the circuit conduction is realized;
3. through the arrangement of the clamp assembly, not only can liquid conveying be realized, but also sealing can be realized through the clamp assembly attaching to the liquid inlet on the microfluidic chip;
4. the whole structure has higher reliability, convenient operation, simple structure and convenient maintenance.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic view of the overall structure of a microfluidic chip holder of the present application when the microfluidic chip is mounted;
FIG. 2 is a schematic view of the first and second rotary connection blocks of the present application mated with each other;
FIG. 3 is a schematic view of the structure of the bearing, steel ball and jackscrew of the present application;
FIG. 4 is a schematic view of the structure of the spring probe and clip of the present application;
FIG. 5 is a schematic view of the structure of the contacts in the present application;
FIG. 6 is a schematic structural view of the locking mechanism of the present application;
fig. 7 is a schematic structural diagram of a microfluidic chip in the present application.
Reference numerals: 1. a fixed clamping plate; 2. overturning the clamping plate; 3. a first rotational connection block; 4. the second rotating connecting block; 5. rotating the connecting groove; 6. a rotary connection part; 7. steel balls; 8. a bearing; 9. a jackscrew; 10. a first buckling end; 11. the second buckling end; 12. a groove; 13. a reference side; 14. a positioning piece; 15. a bonding part; 16. a clip assembly; 17. a first probe assembly; 18. a second probe assembly; 19. a contact assembly; 20. an insulating sleeve; 21. a locking spring; 22. a locking lever; 221. a rod body; 222. a clamping part; 223. a lifting part; 23. a locking clamping groove; 24. a positioning groove; 25. spring plunger.
Detailed Description
Embodiments of the present application are described in detail below with reference to the accompanying drawings.
Other advantages and effects of the present application will become apparent to those skilled in the art from the present disclosure, when the following description of the embodiments is taken in conjunction with the accompanying drawings. It will be apparent that the described embodiments are only some, but not all, of the embodiments of the present application. The present application may be embodied or carried out in other specific embodiments, and the details of the present application may be modified or changed from various points of view and applications without departing from the spirit of the present application. It should be noted that the following embodiments and features in the embodiments may be combined with each other without conflict. All other embodiments, which can be made by one of ordinary skill in the art based on the embodiments herein without making any inventive effort, are intended to be within the scope of the present application.
It is noted that various aspects of the embodiments are described below within the scope of the following claims. It should be apparent that the aspects described herein may be embodied in a wide variety of forms and that any specific structure and/or function described herein is merely illustrative. Based on the present application, one skilled in the art will appreciate that one aspect described herein may be implemented independently of any other aspect, and that two or more of these aspects may be combined in various ways. For example, apparatus may be implemented and/or methods practiced using any number and aspects set forth herein. In addition, such apparatus may be implemented and/or such methods practiced using other structure and/or functionality in addition to one or more of the aspects set forth herein.
It should also be noted that the illustrations provided in the following embodiments merely illustrate the basic concepts of the application by way of illustration, and only the components related to the application are shown in the drawings and are not drawn according to the number, shape and size of the components in actual implementation, and the form, number and proportion of the components in actual implementation may be arbitrarily changed, and the layout of the components may be more complicated.
In addition, in the following description, specific details are provided in order to provide a thorough understanding of the examples. However, it will be understood by those skilled in the art that the present invention may be practiced without these specific details.
The following describes the technical solutions provided by the embodiments of the present application with reference to the accompanying drawings.
As shown in fig. 1, the embodiment of the present disclosure provides a microfluidic chip fixture, which includes a fixing clamping plate 1 and a turnover clamping plate 2 that can be fastened to each other, and the fixing clamping plate 1 is rotationally connected with the turnover clamping plate 2.
As shown in fig. 1 and 2, the fixed clamping plate 1 is integrally provided with a first rotating connecting block 3, and the first rotating connecting block 3 is arranged at 90 degrees with the fixed clamping plate 1. The turnover clamping plate 2 is integrally provided with a second rotation connecting block 4, and the second rotation connecting block 4 is arranged at 90 degrees with the turnover clamping plate 2.
The middle region of the first rotating connecting block 3 is provided with a rotating connecting groove 5, the middle region of the second rotating connecting block 4 is integrally provided with a rotating connecting part 6 matched with the rotating connecting groove 5, and the rotating connecting part 6 stretches into the rotating connecting groove 5 and is rotationally connected with the rotating connecting groove 5.
As shown in fig. 2 and 3, rolling grooves are respectively formed at two ends of the rotary connecting part 6, and steel balls 7 are arranged in the rolling grooves.
Bearings 8 are respectively arranged on two sides of the rotary connecting groove 5, steel balls 7 at two ends of the rotary connecting part 6 are respectively abutted against the bearings 8 on two sides of the rotary connecting groove 5, and the steel balls 7 and the bearings 8 are coaxially arranged;
the second rotating connecting block 4 is connected with two jackscrews 9 in a threaded manner, the two jackscrews 9 are respectively abutted against the two steel balls 7, so that the two steel balls 7 are respectively contacted with the two bearings 8, the rotating connection of the first rotating connecting block 3 and the second rotating connecting block 4 is realized, and rolling friction is carried out between the steel balls 7 and the bearings 8 when the first rotating connecting block 3 rotates relative to the second rotating connecting block 4.
Through rotating connecting portion 6, rotate spread groove 5, steel ball 7, jackscrew 9 and bearing 8, realize the rotation connection between fixed splint 1 and the upset splint 2, and through the rolling friction between steel ball 7 and the bearing 8, when can making to do relative rotation between upset splint 2 and the fixed splint 1, the location is more accurate to can also effectively reduce rocking between upset splint 2 and the fixed splint 1, make the mutual lock between upset splint 2 and the fixed splint 1 inseparabler.
As shown in fig. 1, the end of the fixing splint 1 for buckling with the turning splint 2 is a first buckling end 10, and the end of the turning splint 2 for buckling with the fixing splint 1 is a second buckling end 11. The first buckling end 10 is provided with a groove 12 for placing a microfluidic chip, and the groove 12 is a rectangular groove. The width direction of the groove 12 is consistent with the width direction of the fixed clamping plate 1, one side of the groove 12 in the width direction is a reference side 13, and the other side of the groove 12 in the width direction is provided with a positioning piece 14 in a penetrating way. The positioning pieces 14 are positioning plungers, two positioning plungers are arranged, and the two positioning plungers are distributed along the length direction of the fixed clamping plate 1. One end of each positioning plunger extends into the groove 12 and is used for propping the microfluidic chip placed in the groove 12 against the reference side 13 so as to realize accurate positioning of the microfluidic chip in the groove 12.
In other embodiments, the positioning members 14 may also be positioning pins, and the number of positioning members 14 may also be one, three, or other numbers.
The second buckling end 11 is integrally provided with a fitting part 15, and the fitting part 15 is a boss protruding from the surface of the second buckling end 11. The surface of the abutment 15 facing away from the second snap end 11 is provided with a clip assembly 16 and a first probe assembly 17.
As shown in fig. 1, 4 and 5, the clip assembly 16 includes a plurality of clips distributed on the surface of the attaching portion 15, and the clips are made of soft silica gel material, and have good sealing performance. One end of the clamp is used for being connected with a liquid inlet pipe, and the other end of the clamp is used for being connected with a liquid inlet on the micro-fluidic chip so as to realize liquid conveying of the micro-fluidic chip. When the clamp is connected with the liquid inlet on the microfluidic chip, the clamp and the liquid inlet are in a sealing state, and liquid can be limited from seeping out from a gap between the clamp and the liquid inlet, so that the microfluidic chip is guaranteed to have good sealing performance in the use process.
The first probe assembly 17 is composed of a plurality of elastic probes disposed on the surface of the attaching portion 15. The position distribution of a plurality of elastic probes on the surface of the attaching part 15 corresponds to the position distribution of each electrode on the microfluidic chip one by one.
In the actual use process, when the turnover clamping plate 2 is buckled with the fixed clamping plate 1 through rotation and the positioning piece 14 supports the microfluidic chip on the reference side 13, a plurality of elastic probes on the surface of the attaching part 15 are connected with the electrodes on the microfluidic chip in a one-to-one correspondence manner, so that each electrode can be ensured to be connected, and the connection of a circuit is ensured.
In other embodiments, if the microfluidic chip is placed in the groove 12, the surface of the microfluidic chip is flush with the surface of the first fastening end 10, and the first probe assembly 17 and the clamp assembly 16 can be directly disposed on the surface of the second fastening end 11 without disposing the attaching portion 15, so as to realize electrode connection and liquid inlet connection with the microfluidic chip in the groove 12.
The surface of the second snap-fit end 11 is also provided with a second probe assembly 18. The second probe assembly 18 is composed of a plurality of elastic probes uniformly distributed on both sides of the attaching portion 15. The second probe assembly 18 is connected in series with the first probe assembly 17.
The surface of the first snap-fit end 10 is provided with a contact assembly 19, the contact assembly 19 being composed of a plurality of contacts evenly distributed on both sides of the recess 12. The number of the contacts on the surface of the first buckling end 10 is the same as the number of the elastic probes on the surface of the second buckling end 11, and the positions of the contacts are in one-to-one correspondence.
In the actual use process, when the turnover clamping plate 2 is buckled with the fixed clamping plate 1 through rotation and the positioning piece 14 supports the microfluidic chip against the reference side 13, a plurality of elastic probes on the surface of the second buckling end 11 are in one-to-one correspondence with a plurality of contacts on the surface of the first buckling end 10. Because the first probe assembly 17 and the second probe assembly 18 are connected in series, after the turnover clamping plate 2 and the fixing clamping plate 1 are buckled, a series circuit is formed among the first probe assembly 17, the second probe assembly 18, the contact assembly 19 and the electrodes of the microfluidic chip, and the circuit conduction of the microfluidic chip can be realized only by connecting a wire on one side of the fixing clamping plate 1. Because the wire can unilaterally set up, consequently the wire can not appear buckling the condition because of the rotation of upset splint 2 relative to fixed splint 1 to the wire can not appear exposing the condition on upset splint 2, and the reliability is higher in the circular telegram use.
Further, the outer circumferences of the elastic probe and the contact are provided with an insulating sleeve 20. Through setting up insulating sleeve 20, can guarantee that elasticity probe and contact all can have good insulating property, can effectively avoid the emergence of electric leakage phenomenon for the whole in-process of using has more reliability.
As shown in fig. 1 and 6, a locking mechanism is arranged on the turnover clamping plate 2, and the locking mechanism is used for locking the turnover clamping plate 2 and the fixing clamping plate 1 in a buckling state so as to fix the microfluidic chip.
The turnover clamping plate 2 is provided with a mounting hole, and the locking mechanism comprises a locking spring 21 and a locking rod 22 penetrating through the mounting hole.
The locking lever 22 includes a lever body 221, and a clamping portion 222 and a pulling portion 223 respectively located at both ends of the lever body 221. The rod 221 is inserted into the mounting hole, and the axis of the rod 221 is perpendicular to the overturning clamping plate 2. The clamping portion 222 is located at one end of the rod 221 near the fixing clamp plate 1, and has a long straight plate structure. The lifting part 223 is located at one end of the rod 221 away from the fixed clamping plate 1, is in a bump shape, and is provided with edges at the periphery so as to be convenient for holding by hands. The rod 221 is adjustable in the axial direction relative to the flip clamp 2.
The locking spring 21 is coaxially sleeved on the periphery of the rod body 221, one end of the locking spring 21 is fixedly connected with the turnover clamping plate 2, and the other end of the locking spring 21 is fixedly connected with the lifting part 223.
When the turnover clamping plate 2 and the fixed clamping plate 1 are buckled, the locking spring 21 drives the lifting part 223 to move away from the turnover clamping plate 2, so that the clamping part 222 is abutted against one end of the fixed clamping plate 1, which is away from the turnover clamping plate 2.
Further, the rod 221 can rotate around the axis in the mounting hole, and the fixing clamp plate 1 is provided with a locking slot 23 for the clamping portion 222 to pass through.
When the turnover clamping plate 2 and the fixed clamping plate 1 are buckled, the clamping part 222 passes through the locking clamping groove 23 and rotates by a fixed angle, and under the action of the locking spring 21, the two ends of the clamping part 222 are abutted against the end face of the fixed clamping plate 1, which is away from the turnover clamping plate 2. In the embodiment of the present application, the fixed angle is 90 degrees.
In other embodiments, the fixed angle may be 45 degrees, 60 degrees, or other angles.
Further, a plurality of positioning slots 24 are disposed on the circumferential sidewall of the rod 221, and the plurality of positioning slots 24 are uniformly distributed on the rod 221 in the circumferential direction. In the embodiment of the present application, the number of the positioning grooves 24 is four, and the angular interval between the adjacent positioning grooves 24 is 90 degrees.
The turnover clamping plate 2 is connected with a spring plunger 25 in a sliding manner, the sliding direction of the spring plunger 25 is perpendicular to the axial direction of the rod body 221, and one end of the spring plunger 25 is propped against the peripheral wall of the rod body 221 or the bottom of the positioning groove 24.
The spring plungers 25 perform a sliding movement with respect to the flip-flop clips 2 in the axial direction when the lever 221 rotates, and when the spring plungers 25 are moved from one positioning groove 24 into the other adjacent positioning groove 24, the lever 221 rotates the grip 222 by 90 degrees.
In the actual use process, if the turnover clamping plate 2 and the fixed clamping plate 1 need to be locked, only the lifting and pulling part 223 needs to be pushed, the clamping part 222 passes through the locking clamping groove 23, and then the rod body 221 rotates 90 degrees, so that the spring plunger 25 moves from one positioning groove 24 to the other positioning groove 24, the lifting and pulling part 223 is released, and the two ends of the locking part are abutted against the end face of the fixed clamping plate 1, which is away from the turnover clamping plate 2, by means of the acting force of the locking spring 21, so that the locking and the disassembling are convenient. In the locking process, an operator can clearly sense whether the spring plunger 25 is clamped in the positioning groove 24, and once the spring plunger 25 is clamped in the adjacent positioning groove 24, namely, the angle of the rod body 221 is rotated 90 degrees, the angle of the rod body 221 is adjusted in place, and the operator is prompted to not need to adjust the angle of the rod body 221 again; furthermore, after the spring plunger 25 is clamped into the positioning groove 24, the spring plunger 25 is not easy to separate from the positioning groove 24 under the action of external force, so that the rotation of the locking part can be limited through the cooperation of the spring plunger 25 and the positioning groove 24, the locking state between the fixed clamping plate 1 and the turnover clamping plate 2 is more stable, and the microfluidic chip is ensured to have more stable performance and higher reliability in the clamped use process.
The embodiment of the present disclosure further provides a microfluidic chip, as shown in fig. 7, including a chip body, where the size and the electrode distribution of the chip body are adapted to any one of the microfluidic chip fixtures described above.
The chip body is provided with a sample inlet, a sample pool, a sample converging port, a runner, a liquid inlet, an electrode and a liquid outlet needle. Wherein, the liquid outlet needle comprises a sorting port and a waste liquid port.
Wherein, the electrode on the chip body is arranged in one-to-one correspondence with a plurality of elastic probes on the surface of the attaching part 15. The liquid inlet on the chip body is arranged in one-to-one correspondence with a plurality of hoops on the surface of the attaching part 15.
When the overturning clamping plate 2 is buckled with the fixed clamping plate 1 through rotation and the positioning piece 14 supports the chip body against the reference side 13, the electrodes on the chip body are connected with the elastic probes in a one-to-one correspondence mode to realize circuit connection, and the liquid inlets on the chip body are connected with the clamping clamps in a one-to-one correspondence mode to realize liquid conveying.
The microfluidic chip integrates the electrode and the liquid outlet needle with the sorting port and the liquid outlet in the microfluidic chip, and can realize liquid sorting in the chip.
In this specification, each embodiment is described in a progressive manner, and identical and similar parts of each embodiment are all referred to each other, and each embodiment focuses on differences from other embodiments.
The foregoing is merely specific embodiments of the present application, but the scope of the present application is not limited thereto, and any changes or substitutions easily conceivable by those skilled in the art within the technical scope of the present application should be covered in the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.

Claims (10)

1. The microfluidic chip clamp is characterized by comprising a fixed clamp plate (1) and a turnover clamp plate (2) which can be mutually buckled, wherein the turnover clamp plate (2) is rotationally connected with the fixed clamp plate (1);
a groove (12) for placing a microfluidic chip is formed in the fixed clamping plate (1), a positioning piece (14) is arranged on one side of the groove (12), one side, away from the positioning piece (14), of the groove (12) is a reference side (13), and the positioning piece (14) is used for propping the microfluidic chip placed in the groove (12) against the reference side (13);
the turnover clamping plate (2) is provided with a clamp assembly (16) and a first probe assembly (17);
when the turnover clamping plate (2) is buckled with the fixed clamping plate (1) through rotation and the positioning piece (14) supports the microfluidic chip against the reference side (13), the first probe assembly (17) is matched with an electrode on the microfluidic chip and realizes circuit connection, one end of the clamp assembly (16) is used for being connected with a liquid inlet pipe, and the other end of the clamp assembly (16) is used for being connected with a liquid inlet on the microfluidic chip so as to realize liquid conveying of the microfluidic chip;
the turnover clamping plate (2) or the fixed clamping plate (1) is provided with a locking mechanism, and the locking mechanism is used for locking the turnover clamping plate (2) and the fixed clamping plate (1) which are in a buckling state.
2. The microfluidic chip clamp according to claim 1, wherein a fitting part (15) is arranged on the surface of the turnover clamping plate (2) for being buckled with the fixed clamping plate (1);
the first probe assembly (17) is arranged on the surface of the attaching part (15) far away from the overturning clamping plate (2);
when the turnover clamping plate (2) is buckled with the fixed clamping plate (1) through rotation and the positioning piece (14) supports the microfluidic chip on the reference side (13), the surface of the attaching part (15) deviating from the turnover clamping plate (2) is attached to the surface of the microfluidic chip in the groove (12), and the first probe assembly (17) is matched with an electrode on the microfluidic chip and is connected with a circuit.
3. The microfluidic chip fixture according to claim 1, wherein a second probe assembly (18) is arranged on the surface of the turnover clamping plate (2) for being buckled with the fixed clamping plate (1), a contact assembly (19) is arranged on the surface of the fixed clamping plate (1) for being buckled with the turnover clamping plate (2), and the second probe assembly (18) is connected with the first probe assembly (17) in series;
when the turnover clamping plate (2) is buckled with the fixing clamping plate (1) through rotation and the positioning piece (14) supports the microfluidic chip on the reference side (13), the second probe assembly (18) is matched with the contact assembly (19), and the first probe assembly (17) is matched with an electrode on the microfluidic chip, so that circuit connection among the first probe assembly (17), the electrode on the microfluidic chip, the second probe assembly (18) and the contact assembly (19) is realized.
4. A microfluidic chip holder according to claim 3, wherein the first probe assembly (17) and the second probe assembly (18) each consist of a number of elastic probes.
5. The microfluidic chip holder according to claim 4, wherein the contact assembly (19) consists of several contacts;
the outer periphery of the contact and the outer periphery of the elastic probe are both provided with insulating sleeves (20).
6. A microfluidic chip fixture according to claim 3, wherein the turnover clamping plate (2) is provided with a mounting hole, and the locking mechanism comprises a locking spring (21) and a locking rod (22) penetrating through the mounting hole;
the locking rod (22) comprises a rod body (221), a clamping part (222) and a lifting part (223) which are respectively positioned at two ends of the rod body (221), the rod body (221) is arranged in the mounting hole in a penetrating mode, the axis of the rod body (221) is perpendicular to the overturning clamping plate (2), the clamping part (222) is positioned at one end, close to the fixed clamping plate (1), of the rod body (221), the lifting part (223) is positioned at one end, far away from the fixed clamping plate (1), of the rod body (221), and the rod body (221) is adjustable relative to the overturning clamping plate (2) along the axis direction;
one end of the locking spring (21) is fixedly connected with the overturning clamping plate (2), and the other end of the locking spring (21) is fixedly connected with the lifting part (223);
when the turnover clamping plate (2) and the fixed clamping plate (1) are buckled, the locking spring (21) drives the lifting part (223) to move away from the turnover clamping plate (2), so that the clamping part (222) is abutted against one end of the fixed clamping plate (1) deviating from the turnover clamping plate (2).
7. The microfluidic chip fixture according to claim 6, wherein the rod body (221) can rotate in the mounting hole around the axis, and the fixing clamping plate (1) is provided with a locking clamping groove (23) for the clamping part (222) to pass through;
when the overturning clamping plate (2) is buckled with the fixed clamping plate (1), the clamping part (222) is locked in the clamping groove (23) and rotated for a fixed angle, and under the action of the locking spring (21), the two ends of the clamping part (222) are abutted against the end face of the fixed clamping plate (1) deviating from the overturning clamping plate (2).
8. The microfluidic chip fixture according to claim 7, wherein a plurality of positioning grooves (24) are formed in the circumferential side wall of the rod body (221), and the plurality of positioning grooves (24) are uniformly distributed in the circumferential direction on the rod body (221);
the turnover clamping plate (2) is connected with a spring plunger (25) in a sliding manner, the sliding direction of the spring plunger (25) is perpendicular to the axial direction of the rod body (221), and one end of the spring plunger (25) is propped against the peripheral wall of the rod body (221) or the groove bottom of the positioning groove (24);
the spring plunger (25) performs sliding movement relative to the overturning clamping plate (2) along the axial direction when the rod body (221) rotates, and when the spring plunger (25) moves into the other adjacent positioning groove (24) from one positioning groove (24), the rod body (221) drives the clamping part (222) to rotate for a fixed angle.
9. The microfluidic chip clamp according to claim 1, wherein a first rotating connection block (3) is arranged on the fixed clamping plate (1), and a second rotating connection block (4) is arranged on the turnover clamping plate (2);
a rotary connecting groove (5) is formed in the middle area of the first rotary connecting block (3), a rotary connecting part (6) matched with the rotary connecting groove (5) is arranged in the middle area of the second rotary connecting block (4), and the rotary connecting part (6) stretches into the rotary connecting groove (5) and is rotationally connected with the rotary connecting groove (5);
rolling grooves are respectively formed in two ends of the rotating connecting part (6), steel balls (7) are arranged in the rolling grooves, bearings (8) are respectively arranged on two sides of the rotating connecting part (5), the steel balls (7) at two ends of the rotating connecting part (6) are respectively abutted to the bearings (8) on two sides of the rotating connecting part (5), and the steel balls (7) and the bearings (8) are coaxially arranged;
the second rotating connecting block (4) is further provided with two jackscrews (9), and the two jackscrews (9) are respectively abutted against the two steel balls (7) so that the two steel balls (7) are respectively in rolling friction with the two bearings (8).
10. The microfluidic chip is characterized by comprising a chip body, wherein the microfluidic chip clamp is required to be 1-9 according to the size and electrode distribution adaptation Yu Quanli of the chip body.
CN202310615191.1A 2023-05-29 2023-05-29 Microfluidic chip fixture and microfluidic chip Pending CN116550404A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310615191.1A CN116550404A (en) 2023-05-29 2023-05-29 Microfluidic chip fixture and microfluidic chip

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202310615191.1A CN116550404A (en) 2023-05-29 2023-05-29 Microfluidic chip fixture and microfluidic chip

Publications (1)

Publication Number Publication Date
CN116550404A true CN116550404A (en) 2023-08-08

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN202310615191.1A Pending CN116550404A (en) 2023-05-29 2023-05-29 Microfluidic chip fixture and microfluidic chip

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Country Link
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116920979A (en) * 2023-09-12 2023-10-24 微纳动力(北京)科技有限责任公司 Micro-fluidic chip fixture

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116920979A (en) * 2023-09-12 2023-10-24 微纳动力(北京)科技有限责任公司 Micro-fluidic chip fixture
CN116920979B (en) * 2023-09-12 2023-12-05 微纳动力(北京)科技有限责任公司 Micro-fluidic chip fixture

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