CN116549591A - Traditional Chinese medicine composition for treating stomachache and application thereof - Google Patents
Traditional Chinese medicine composition for treating stomachache and application thereof Download PDFInfo
- Publication number
- CN116549591A CN116549591A CN202310555516.1A CN202310555516A CN116549591A CN 116549591 A CN116549591 A CN 116549591A CN 202310555516 A CN202310555516 A CN 202310555516A CN 116549591 A CN116549591 A CN 116549591A
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- China
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- traditional chinese
- chinese medicine
- stomach
- medicine composition
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- Pending
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Abstract
The invention discloses a traditional Chinese medicine composition for treating stomachache and application thereof, wherein the traditional Chinese medicine composition is prepared from 12 traditional Chinese medicines of radix zanthoxyli, bighead atractylodes rhizome, premna microphylla, hawthorn root, fructus amomi, serissa serissoides, grassleaf sweelflag rhizome, rhizoma polygoni multiflori, dandelion, iron clad gold, dried ginger and hericium erinaceus. The composition has the effects of warming spleen and stomach, regulating qi to alleviate pain, and promoting diuresis and detoxicating, and can be used for treating gastralgia caused by cold evil, stomach obstruction, deficiency cold of spleen and stomach, cold dampness obstruction, liver qi, stomach obstruction, blood stasis stagnation and the like; the composition has precise and appropriate compatibility, widens the application of various cold-back medicinal materials, can effectively improve the stomachache symptoms caused by acute and chronic gastritis, gastric ulcer and the like by clinical use, has the characteristics of quick response, short treatment course, low recurrence rate and the like, and has no toxic or side effect.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating stomachache and application thereof.
Background
The name of gastralgia was first recorded in the interior meridian, as indicated in Ling Shu-pathogenic qi viscera disease shape: the term "stomach-disease, abdominal distention, and pain in the stomach as the heart and the abdomen" refers to a disease with pain in the stomach and abdomen as the main symptom, which is also called "stomach-heart pain", "heart pain", etc. In western medicine, "chronic gastritis", "gastric ulcer", "gastric cancer" etc. can be treated by syndrome differentiation with reference to "epigastric pain". Modern medical research shows that the pathological changes of stomach diseases are based on gastric mucosa congestion water, and mucosa becomes thinner, swelled or becomes nodular or rough, the disease course is longer, if the disease is not treated in time or is improper in treatment, gastric cancer is easy to develop over time. Along with the improvement of living standard, the increase of working pressure, the acceleration of life rhythm and the change of eating habits, the prevalence of the disease in people in China reaches 60 percent, and the disease has complex condition, long disease course, high clinical recurrence rate and low cure rate, and influences the normal life and work and study of people.
Western medicine treatment generally treats dyspepsia with conventional methods such as morpholine, mosapride, etc. for promoting gastric motility; patients with gastritis and gastric ulcer are commonly treated with proton pump inhibitors (omeprazole, lansoprazole, pantoprazole, etc.), combined with gastric mucosa protectants (sucralfate, colloidal bismuth pectin), and combined with helicobacter pylori infection. Generally, western medicines can treat gastralgia, gastrectasia and pantothenic acid, only temporarily relieve symptoms, can not radically treat symptoms, can not treat the root cause, and can be used immediately after stopping the medicine, so that stomach ache and other stomach diseases frequently occur repeatedly. The traditional Chinese medicine for treating epigastric pain has unique advantages, can improve clinical symptoms, help repair gastric mucosa, strengthen physique, and has the characteristics of obvious clinical curative effect, high safety and low recurrence rate.
The traditional Chinese medicines and western medicines for treating the stomachache are various in types, the western medicines are taken fast, the symptoms and the root causes are not treated, certain toxic and side effects can be produced, and the problems of long treatment course, slow effect, poor patient compliance and the like exist in the traditional Chinese medicines. Therefore, the development of the medicine for treating the stomachache has the advantages of quick response, short course of treatment, low recurrence rate and no side effect, can benefit the patients with the stomachache, and has good social benefit.
Disclosure of Invention
The invention aims at providing a traditional Chinese medicine composition for treating stomachache and application thereof, aiming at the defects of the prior art. The invention has the characteristics of quick effect, short treatment course, low recurrence rate and the like, has obvious curative effect on stomachache caused by cold evil, stomach obstruction, deficiency cold in spleen and stomach, cold dampness middle obstruction, liver qi, stomach obstruction, blood stasis stagnation and the like, and has no toxic effect.
The aim of the invention is realized by the following technical scheme: the invention provides a traditional Chinese medicine composition for treating stomachache, which is prepared from the following raw materials in parts by weight: 5-30 parts of mountain chicken pepper root, 2-20 parts of bighead atractylodes rhizome, 3-30 parts of beancurd firewood, 5-30 parts of hawthorn root, 2-20 parts of fructus amomi, 2-20 parts of serissa serissoide, 2-20 parts of grassleaf sweelflag rhizome, 4-20 parts of rhizoma polygoni multiflori, 2-20 parts of dandelion, 3-15 parts of iron ladle gold, 2-15 parts of dried ginger and 2-15 parts of hericium erinaceus.
Preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20 parts of mountain chicken pepper root, 15 parts of bighead atractylodes rhizome, 15 parts of beancurd stick, 30 parts of hawthorn root, 20 parts of fructus amomi, 5 parts of serissa serissoides, 1 part of grassleaf sweelflag rhizome, 5 parts of rhizoma polygonati, 5 parts of dandelion, 10 parts of iron-clad gold, 10 parts of dried ginger and 15 parts of hericium erinaceus.
Further, the traditional Chinese medicine composition is a preparation prepared by taking medicinal powder of raw materials and/or water extract of the raw materials and/or organic solvent extract of the raw materials as active ingredients and adding pharmaceutically acceptable auxiliary materials.
The preparation is an oral preparation; the oral preparation is a modern Chinese medicinal preparation such as mixture, paste, granule, pill, capsule, tablet, powder, medicated wine or syrup.
The invention also provides a preparation method of the traditional Chinese medicine composition for treating stomachache, which comprises the following steps:
(1) Weighing the raw materials according to the weight ratio;
(2) The powder obtained by grinding the raw materials and/or the water extract of the raw materials and/or the organic solvent extract of the raw materials are used as active ingredients, and pharmaceutically acceptable auxiliary materials or auxiliary ingredients are added to prepare the traditional Chinese medicine composition.
The invention also provides application of the traditional Chinese medicine composition for treating the stomachache, and application of the traditional Chinese medicine composition in preparation of a medicine for treating the stomachache.
Further, the Chinese medicinal composition is applied to the preparation of medicaments for treating stomachache caused by cold evil, stomach obstruction, food stagnation, deficiency-cold in spleen and stomach, cold dampness middle obstruction, liver qi invading the stomach, blood stasis stagnation and the like.
The medicine provided by the invention is a medicine capable of rapidly acting to treat stomachache, and has the characteristics of rapid effect, short treatment course, low recurrence rate, no toxic or side effect and the like.
The raw materials in the invention are completely combined according to the principle of dialectical treatment of the traditional Chinese medicine theory, and the root of the zanthoxylum schinifolium has the effects of dispelling cold, regulating qi and relieving pain; the bighead atractylodes rhizome has the effects of strengthening spleen, tonifying qi and eliminating dampness, and the 2 medicines have the effects of diffusing and descending qi, and eliminating dampness and ascending transportation, so the bighead atractylodes rhizome is a monarch medicine; the premna microphylla has the effects of removing dampness and toxic materials, astringing and stopping bleeding, promoting the circulation of blood, resolving stagnation, promoting digestion and invigorating stomach, and the fructus amomi has the effects of warming spleen and regulating qi, resolving dampness and relieving vomiting, and 3 Chinese medicinal materials, namely, the fructus crataegi has the effects of enhancing and reducing the healthy energy and is used as ministerial drugs; herba Artemisiae Anomalae has effects of promoting blood circulation for removing blood stasis, promoting diuresis and invigorating spleen, rhizoma Acori Graminei has effects of inducing resuscitation and eliminating phlegm, eliminating dampness and promoting appetite, resolving hard mass and stopping bleeding, herba Taraxaci has effects of clearing heat and detoxicating, detumescence and resolving hard mass, and iron Bao Jinxiao malnutrition has effects of resolving food stagnation, promoting blood circulation and relieving pain, and dry Jiang Wenzhong has effects of dispelling cold, restoring yang and dredging collaterals, and 6 kinds of auxiliary monarch and ministerial drugs are used as adjuvant drugs for treating deficiency and excess syndrome; hericium erinaceus has the effects of strengthening spleen and stomach, tonifying qi and soothing nerves, and harmonizing various medicines. The stomach is the major source of the sea and the barn of food, the spleen is the acquired root, the spleen is the ascending and descending of the stomach, the spleen is the damp-earth and dry-earth and the stomach is the dry-earth and moist-earth. The food can be received and decomposed and transported by micro-transformation to supplement each other to achieve the purpose of treatment. The whole formula is composed of 12 traditional Chinese medicines, and has pungent, slightly bitter and astringent taste and slightly warm nature. Has accurate compatibility, proper dosage, safety and effectiveness and no toxic or side effect, and is a good prescription for treating the stomach ache in the past.
The invention has the following beneficial effects:
(1) The invention has novel and unique prescription, and the combination of the medicines can play roles of regulating qi, relieving pain, warming middle-jiao and strengthening spleen. Has good pain relieving effect on various stomach ache, has satisfactory clinical curative effect in clinical application, can have obvious curative effect in 1 course of treatment, and has the characteristics of quick response, short course of treatment, low recurrence rate, no toxic or side effect and the like.
(2) The raw materials used in the prescription are mostly cold-back medicinal materials, so that the resources of the traditional Chinese medicine treasury are fully developed, and the utilization value of the cold-back medicinal materials is improved. Through scientific formula compatibility, the traditional Chinese medicine composition plays a role in keeping with the innovation spirit, and develops an innovative formula to exert a new curative effect. By utilizing the modern traditional Chinese medicine production technology, the developed product is: the preparation process is scientific, strict and standard, the production cost is low, and the finished product is safe, stable and effective. The resource advantage of the traditional Chinese medicine is practically converted into the advantage of the traditional Chinese medicine industry, the categories of the Chinese patent medicines are enriched, and the traditional Chinese medicine industry is promoted to develop towards high quality.
Detailed Description
The following description of the embodiments of the present invention will clearly and fully describe the technical solutions of the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to fall within the scope of the invention.
Example 1: preparation of Chinese medicinal composition paste
The formula comprises the following components: 250g of mountain chicken pepper root, 100g of bighead atractylodes rhizome, 120g of beancurd stick, 150g of hawthorn root, 100g of fructus amomi, 120g of serissa serissoides, 90g of grassleaf sweelflag rhizome, 150g of rhizoma polygonati, 100g of dandelion, 90g of iron clad gold, 50g of dried ginger and 60g of hericium erinaceus.
The preparation method comprises the following steps: decocting the above materials in water, extracting with water amount 4 times of the total weight of the materials for 2 times and 2 hr each time, filtering, mixing filtrates, concentrating under reduced pressure at 60deg.C to obtain fluid extract with relative density of 1.02, adding 60g Mel, and continuously collecting the extract to obtain soft extract with relative density of 1.30.
Example 2: preparation of Chinese medicinal composition mixture
The formula comprises the following components: 500g of mountain chicken pepper root, 200g of bighead atractylodes rhizome, 300g of beancurd stick, 500g of hawthorn root, 200g of fructus amomi, 200g of six-month snow, 200g of grassleaf sweelflag rhizome, 400g of rhizoma polygonati, 200g of dandelion, 300g of iron clad gold, 200g of dried ginger and 200g of hericium erinaceus.
The preparation method comprises the following steps: decocting in water with water amount of 4 times of total weight of the medicinal materials, extracting for 2 times at each time for 0.5 hr, filtering, mixing filtrates, concentrating under reduced pressure at 60deg.C to obtain 2g crude drug/ml fluid extract, adding Mel 40g and sucrose 160g, dissolving completely, adding purified water to volume of 2000ml, packaging, sterilizing at 121deg.C for 15 min, and packaging to obtain mixture.
Example 3: preparation of traditional Chinese medicine composition pill
The formula comprises the following components: 300g of mountain chicken pepper root, 200g of bighead atractylodes rhizome, 150g of beancurd stick, 300g of hawthorn root, 150g of fructus amomi, 150g of serissa serissoide, 100g of grassleaf sweelflag rhizome, 200g of rhizoma polygonati, 200g of dandelion, 150g of iron clad gold, 100g of dried ginger and 150g of hericium erinaceus.
The preparation method comprises the following steps: pulverizing the above materials into fine powder, mixing, adding water and Mel, making pill, drying, and packaging to obtain pill.
Example 4:
1. clinical study
The clinical data of 61 patients suffering from stomachache, which are collected and treated in 2017, are selected for analysis, and are randomly divided into 3 groups according to different clinical treatment schemes, wherein the number ratio of men to women is 16/15, the ages are 32-63, the average age is 46, the course of disease is 1-10, and the average course of disease is 8.7; the positive control group had 30 cases, the number ratio of men to women was 14/16, the ages were 28 to 60, the average age was 44, the course of the disease was 1 to 11 years, and the average course of the disease was 9.1 years. The independence data and mean data differences in the clinical data of the two groups of patients were statistically significant (P > 0.05). The two groups of clinical effects, recurrence rate and adverse reaction incidence rate are compared.
1.1 treatment regimens
Treatment group: the Chinese medicinal composition prepared in the example 1 of the invention is taken for soft extract, and the curative effect is counted after 1 treatment course by taking 10g each time and 2 times a day with 7 days as 1 treatment course.
Positive control group: the capsule for nourishing stomach is taken 2 times a day, 3 capsules are taken before meals, 1 course of treatment is taken for 7 days, and the curative effect is counted after 1 course of treatment.
1.2, efficacy comparison
The clinical efficacy of two groups of patients is evaluated according to the diagnosis efficacy standard of traditional Chinese medicine differentiation. The effect is shown: the spleen and stomach reactions such as epigastric pain, abdominal distension, acid distension and the like of the patient disappear, and the gastric mucosa tissues of the patient are restored to be normal after gastroscopy; the method is effective: the gastric abscess and spleen and stomach reactions are obviously relieved, but the gastric mucosa tissues have mild congestion after gastroscopy; invalidation: the clinical symptoms are unchanged and even aggravated. Time to effect: the time when the spleen and stomach reactions are obviously relieved or disappeared is recorded as the onset time. Recurrence: effective after treatment, and has obvious symptom recurrence within three months. Total effective rate= (number of significant cases+number of effective cases)/total case×100%.
1.3, observed index
Comparing three groups of traditional Chinese medicine syndrome scores before and after treatment by adopting the traditional Chinese medicine syndrome differentiation dispute curative effect standard, and scoring for chest distress, belch and long sigh dimension by 0, 1, 2 and 3 minutes; the stomach distending pain and the abdominal distension after eating are scored by 0, 2, 4 and 6 points, and the higher the score is, the more serious the symptoms are.
Quality of life before and after two groups of treatments were evaluated using a quality of life scoring scale, where higher scores suggested better quality of life.
1.4 adverse reaction Rate comparison
After the treatment of the two groups of patients is finished, the incidence of adverse reactions of the two groups of patients is observed and compared.
2. Results
2.1 comparison of clinical efficacy
In terms of relieving clinical symptoms, the total effective rate of the treatment group is 93.5%, which is obviously higher than that of the control group by 83.3%, the average onset time is 1.8 days, which is obviously faster than that of the control group by 2.6 days, the recurrence rate is 3.2%, which is obviously lower than that of the control group by 16.7%. The two groups have obvious difference in treatment effect, and the treatment effect of the treatment group is obviously better than that of the control group, and the details are shown in table 1.
Table 1: comparison of the therapeutic Effect of two groups of patients
2.2 comparison of the observations
The integral of the traditional Chinese medicine symptoms before and after the treatment is reduced, and compared with the control group, the integral of the treatment group such as gastric fullness, chest distress, belch, abdominal distension after eating and long-term sighing is obviously lower, and the difference is obvious, as shown in Table 2.
Table 2: comparison of the integral condition of the traditional Chinese medicine symptoms before and after the two groups of treatments
The quality of life scores before and after treatment were both improved, and compared with the control group, the gastric function recovery, feeding ability, physiological skills, and mood change scores were all significantly improved in the treatment group, with significant differences as detailed in table 3.
Table 3: comparison of quality of life score before and after treatment of two groups
2.3 adverse reactions
Adverse reactions are not found in all treatment groups, and blood, urine, stool and the like are not abnormal before and after the administration, thus indicating that the clinical administration safety is better.
In conclusion, the traditional Chinese medicine composition prepared by taking the traditional Chinese medicine composition has the effects of warming the middle-jiao, strengthening the spleen, regulating qi and relieving pain, and has the advantages of quick response, short treatment course, low recurrence rate and no toxic or side effect. The traditional Chinese medicine composition is scientific and reasonable in formula, the components mutually support, and the dialectical treatment is carried out, so that the traditional Chinese medicine composition is not only used for treating exterior but also used for treating interior, is effectively used for treating gastralgia caused by cold evil, stomach stagnation, spleen and stomach deficiency-cold, cold-dampness middle obstruction, liver qi invading the stomach, blood stasis stagnation and the like, has obvious curative effect, has the effective rate of more than 93 percent, is low in recurrence rate, has no toxic or side effect, is safe to use, and is stable and reliable in curative effect.
The traditional Chinese medicine composition contains various cold-back medicinal materials, has abundant medicinal material resources but lacks application, changes the cold-back medicinal materials with abundant resources into valuable materials after the traditional Chinese medicine composition is industrially applied, increases the application range of the cold-back medicinal materials, can drive local peasants to convert production and increase income, and promotes common abundance.
The invention is a great innovation in the medicine for treating the stomachache, brings good news for patients with repeated attacks of the stomachache such as gastric ulcer, acute and chronic gastritis and the like, and has remarkable social and economic benefits.
It should be understood that, in light of the foregoing, modifications, substitutions and alterations can be made hereto by a person of ordinary skill in the art without departing from the basic technical spirit of the invention as set forth above.
The above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (6)
1. The traditional Chinese medicine composition for treating stomachache is characterized by being prepared from the following raw materials in parts by weight: 5-30 parts of mountain chicken pepper root, 2-20 parts of bighead atractylodes rhizome, 3-30 parts of beancurd firewood, 5-30 parts of hawthorn root, 2-20 parts of fructus amomi, 2-20 parts of serissa serissoide, 2-20 parts of grassleaf sweelflag rhizome, 4-20 parts of rhizoma polygoni multiflori, 2-20 parts of dandelion, 3-15 parts of iron ladle gold, 2-15 parts of dried ginger and 2-15 parts of hericium erinaceus.
2. The traditional Chinese medicine composition for treating stomachache according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 20 parts of mountain chicken pepper root, 15 parts of bighead atractylodes rhizome, 15 parts of beancurd stick, 30 parts of hawthorn root, 20 parts of fructus amomi, 5 parts of serissa serissoides, 1 part of grassleaf sweelflag rhizome, 5 parts of rhizoma polygonati, 5 parts of dandelion, 10 parts of iron-clad gold, 10 parts of dried ginger and 15 parts of hericium erinaceus.
3. The traditional Chinese medicine composition for treating stomachache according to claim 1 or 2, wherein the traditional Chinese medicine composition is a preparation prepared by taking medicinal powder of raw materials and/or water extract of raw materials and/or organic solvent extract of raw materials as active ingredients and adding auxiliary materials.
4. The traditional Chinese medicine composition for treating stomachache according to claim 3, wherein the preparation is an oral preparation; the oral preparation is mixture, paste, granule, pill, capsule, tablet, powder, medicated wine or syrup.
5. Use of a traditional Chinese medicine composition for treating stomach-ache according to any one of claims 1-4, characterized in that the use of the traditional Chinese medicine composition for preparing a medicament for treating stomach-ache.
6. The use according to claim 5, wherein the use of the said Chinese medicinal composition for the preparation of a medicament for the treatment of gastralgia due to pathogenic cold in the stomach, food stagnation, deficiency-cold in the spleen and stomach, cold-dampness obstruction, liver qi invading the stomach or stagnation of blood stasis.
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