CN116549171A - Artificial blood vessel - Google Patents
Artificial blood vessel Download PDFInfo
- Publication number
- CN116549171A CN116549171A CN202310848051.9A CN202310848051A CN116549171A CN 116549171 A CN116549171 A CN 116549171A CN 202310848051 A CN202310848051 A CN 202310848051A CN 116549171 A CN116549171 A CN 116549171A
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- CN
- China
- Prior art keywords
- main body
- support
- ink
- tubular main
- tubular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004204 blood vessel Anatomy 0.000 title claims abstract description 55
- 239000002473 artificial blood Substances 0.000 title claims abstract description 53
- 239000011229 interlayer Substances 0.000 claims abstract description 12
- 239000000463 material Substances 0.000 claims description 20
- 230000002093 peripheral effect Effects 0.000 claims description 16
- 239000003242 anti bacterial agent Substances 0.000 claims description 13
- 230000002792 vascular Effects 0.000 claims description 10
- 229920000642 polymer Polymers 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 8
- 229910052740 iodine Inorganic materials 0.000 claims description 8
- 239000011630 iodine Substances 0.000 claims description 8
- 239000002861 polymer material Substances 0.000 claims description 8
- 159000000009 barium salts Chemical class 0.000 claims description 7
- 150000001621 bismuth Chemical class 0.000 claims description 6
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims description 6
- 239000007769 metal material Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- 238000007639 printing Methods 0.000 claims description 3
- 230000002980 postoperative effect Effects 0.000 abstract description 5
- 230000004660 morphological change Effects 0.000 abstract description 4
- 238000003756 stirring Methods 0.000 description 14
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 230000000845 anti-microbial effect Effects 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000004812 Fluorinated ethylene propylene Substances 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 description 4
- 229920009441 perflouroethylene propylene Polymers 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 230000002411 adverse Effects 0.000 description 3
- 229920000295 expanded polytetrafluoroethylene Polymers 0.000 description 3
- 238000001631 haemodialysis Methods 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000000322 hemodialysis Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 3
- 239000004810 polytetrafluoroethylene Substances 0.000 description 3
- 229920002635 polyurethane Polymers 0.000 description 3
- 239000004814 polyurethane Substances 0.000 description 3
- 239000004925 Acrylic resin Substances 0.000 description 2
- 229920000178 Acrylic resin Polymers 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 239000004599 antimicrobial Substances 0.000 description 2
- 238000000071 blow moulding Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000013530 defoamer Substances 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000007598 dipping method Methods 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000012860 organic pigment Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- RZTYEUCBTNJJIW-UHFFFAOYSA-K silver;zirconium(4+);phosphate Chemical compound [Zr+4].[Ag+].[O-]P([O-])([O-])=O RZTYEUCBTNJJIW-UHFFFAOYSA-K 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 229920004933 Terylene® Polymers 0.000 description 1
- HZEWFHLRYVTOIW-UHFFFAOYSA-N [Ti].[Ni] Chemical compound [Ti].[Ni] HZEWFHLRYVTOIW-UHFFFAOYSA-N 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229910001000 nickel titanium Inorganic materials 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- HWLDNSXPUQTBOD-UHFFFAOYSA-N platinum-iridium alloy Chemical compound [Ir].[Pt] HWLDNSXPUQTBOD-UHFFFAOYSA-N 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 238000011205 postoperative examination Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229910052715 tantalum Inorganic materials 0.000 description 1
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W90/00—Enabling technologies or technologies with a potential or indirect contribution to greenhouse gas [GHG] emissions mitigation
- Y02W90/10—Bio-packaging, e.g. packing containers made from renewable resources or bio-plastics
Landscapes
- Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
The invention provides an artificial blood vessel, which relates to the technical field of medical appliances, and comprises a tubular main body and a support piece capable of being developed under X rays; the wall of the tubular main body comprises an inner pipe wall and an outer pipe wall, a hollow interlayer cavity is formed between the inner pipe wall and the outer pipe wall, and the supporting piece is arranged in the interlayer cavity; the support comprises a spiral support section which is spirally wound outside the inner tube wall of the tubular body; and/or the support piece comprises a plurality of support rings sleeved outside the inner pipe wall of the tubular main body, and the support rings are distributed in a spaced mode along the axial direction of the tubular main body. The invention can at least alleviate the technical problems that the artificial blood vessel in the prior art is not easy to observe in the postoperative service period, and when the morphological changes such as kinking, flattening and the like occur, if the intervention is not timely, puncture is not easy to occur, flow is not smooth, and even the whole artificial blood vessel is possibly scrapped in serious cases.
Description
Technical Field
The invention relates to the technical field of medical appliances, in particular to an artificial blood vessel.
Background
In the prior art, when a hemodialysis patient is treated, an artificial blood vessel is needed to establish a blood vessel passage in the patient, the artificial blood vessel after operation can be sewn in the skin of the patient and cannot be observed, but the life expectancy of the artificial blood vessel is generally 3-5 years, if the maintenance is bad, the blood flow is easily influenced, and even the life expectancy is shortened, specifically: the artificial blood vessel is likely to have morphological changes such as kinking, flattening and the like in the postoperative service period, if the artificial blood vessel is not intervened in time, the problems of difficult puncture, unsmooth flow and the like can be further caused, even the whole artificial blood vessel is likely to be scrapped in serious cases, although the position and the morphology of the artificial blood vessel can be roughly judged through the skin isolation diagnosis, the position and the morphology of the artificial blood vessel are limited by the experience of doctors, the accuracy is also difficult to ensure, the examination after the open operation is more accurate, and the economic burden and the physical and psychological burden of a patient can be deepened undoubtedly.
Furthermore, for intraoperative: in order to ensure that a patient has normal blood flow, a doctor is required to pay extra caution during operation, in order to facilitate the operation of the doctor, in the prior art, axial ink marks are arranged on the peripheral surface of some artificial blood vessels, the artificial blood vessels can be observed under the condition of exposure in operation, and the doctor can adjust according to the ink marks, so that the kink in operation is effectively prevented, but the ink can be released into human blood during operation or service after operation, and thus, the health of the human body is affected in some adverse ways.
Disclosure of Invention
It is an object of the present invention to provide an artificial blood vessel to alleviate at least one of the problems outlined in the background section above, both during and after surgery.
In order to achieve the above purpose, the embodiment of the present invention adopts the following technical scheme:
the embodiment of the invention provides an artificial blood vessel, which comprises a tubular main body and a supporting piece capable of being developed under X-rays; the wall of the tubular main body comprises an inner tube wall and an outer tube wall, a hollow interlayer cavity is formed between the inner tube wall and the outer tube wall, and the supporting piece is arranged in the interlayer cavity. The support comprises a spiral support section which is spirally wound outside the inner tube wall of the tubular body; and/or the support piece comprises a plurality of support rings sleeved outside the inner pipe wall of the tubular main body, and the support rings are distributed in a spaced mode along the axial direction of the tubular main body.
The embodiment of the invention can at least relieve the technical problems that the artificial blood vessel in the prior art is not easy to observe in the postoperative service period, and when the morphological changes such as kinking, flattening and the like occur, if the intervention is not timely, puncture is not easy to occur, flow is not smooth, and even the whole artificial blood vessel is possibly scrapped in serious cases.
In some alternative implementations of the present embodiment: the support extends from one end of the tubular body in the axial direction to the other end of the tubular body in the axial direction; and/or the artificial blood vessel further comprises a developing line capable of developing under X-rays, the developing line is arranged in the interlayer cavity, the developing line is wound on the outer circumferential surface of the inner tube wall of the tubular main body, and the supporting piece is positioned between the developing line and the inner circumferential surface of the outer tube wall of the tubular main body.
In a first type of alternative implementation of the present embodiment: all or part of the supports are each made of a metallic material.
In a second type of alternative implementation of the present embodiment: all or part of the support has an inner cavity filled with a developing material; alternatively, the supports are each made of a mixed material whose composition includes a developing material. Optionally, the developing material comprises tungsten powder, barium salt and/or bismuth salt.
In a third class of alternative implementations of the present embodiment: the outer surfaces of all or part of the support members are each coated with a developing ink capable of developing under X-rays. Optionally, the main components of the developing ink at least comprise aqueous ink and iodine-containing polymer.
In the second or third type of alternative implementation manner of the present embodiment, further optionally, all or part of the supporting member is made of a polymer material; and/or the tubular body is made of a high polymer material, wherein, preferably, the support piece and the tubular body of the artificial blood vessel are made of the high polymer material, so that the support piece is tightly attached to the tubular body of the artificial blood vessel, and the dislocation of the support piece relative to the tubular body of the artificial blood vessel in operation or after operation is avoided.
Furthermore, in some alternative implementations of the present embodiment: the outer peripheral surface of the outer pipe wall of the tubular main body is also provided with a marking line, and the marking line comprises an axial marking line extending along the axial direction of the tubular main body and/or an annular marking line extending along the circumferential direction of the tubular main body and/or a netlike marking line wound along the circumferential direction of the tubular main body; wherein:
the marking line is etched on the outer peripheral surface of the tubular main body by laser; or the marking line is an ink line formed by printing ink on the outer peripheral surface of the tubular main body, and the outer peripheral surface of the outer pipe wall of the tubular main body is further coated with a transparent film, and the transparent film covers the ink line.
Preferably, the main components of the ink at least comprise water-based ink and silver-carrying antibacterial agent.
In particular, in the context of the present invention, the foregoing "and/or" means "and/or" preceding structures or components are provided simultaneously or selectively with "and/or" following structures or components.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present invention, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic structural view of an embodiment of a support member including a helical support section in an artificial blood vessel according to an embodiment of the present invention;
FIG. 2 is a schematic structural view of an embodiment of a support member including a plurality of support rings in an artificial blood vessel according to an embodiment of the present invention;
FIG. 3 is a schematic structural diagram of an embodiment of an artificial blood vessel according to an embodiment of the present invention further including development lines;
FIG. 4 is a radial cross-sectional view of the support member of FIGS. 1-3;
FIG. 5 is a second radial cross-sectional view of the support of FIGS. 1-3;
fig. 6 is a radial cross-sectional view of the support member of fig. 1-3.
Icon: 1-a tubular body; 11-inner tube wall; 12-outer tube wall; 13-an interlayer cavity; 2-a support; 21-a helical support section; 22-a support ring; 3-developing lines; 4-axially marking the line.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments of the present invention. The components of the embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the invention, as presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It should be noted that: like reference numerals and letters denote like items in the following figures, and thus once an item is defined in one figure, no further definition or explanation thereof is necessary in the following figures.
In the description of the present invention, it should be noted that, directions or positional relationships indicated by terms such as "upper", "lower", "inner", "outer", etc., are directions or positional relationships based on those shown in the drawings, or those that are conventionally put in use, are merely for convenience of describing the present invention and simplifying the description, and do not indicate or imply that the apparatus or elements to be referred to must have a specific direction, be constructed and operated in a specific direction, and thus should not be construed as limiting the present invention. Furthermore, the terms "first," "second," "third," and the like are used merely to distinguish between descriptions and should not be construed as indicating or implying relative importance.
In the description of the present invention, it should also be noted that, unless explicitly specified and limited otherwise, the terms "disposed", "connected" and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected or integrally connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.
Some embodiments of the present invention are described in detail below with reference to the accompanying drawings. The following embodiments and features of the embodiments may be combined with each other without conflict.
In the prior art, when a hemodialysis patient is treated, an artificial blood vessel is needed to establish a blood vessel passage in the patient, the artificial blood vessel after operation can be sewn in the skin of the patient and cannot be observed, but the life expectancy of the artificial blood vessel is generally 3-5 years, if the maintenance is bad, the blood flow is easily influenced, and even the life expectancy is shortened, specifically: the artificial blood vessel is likely to have morphological changes such as kinking, flattening and the like in the postoperative service period, if the artificial blood vessel is not intervened in time, the problems of difficult puncture, unsmooth flow and the like can be further caused, even the whole artificial blood vessel is likely to be scrapped in serious cases, although the position and the morphology of the artificial blood vessel can be roughly judged through the skin isolation diagnosis, the position and the morphology of the artificial blood vessel are limited by the experience of doctors, the accuracy is also difficult to ensure, the examination after the open operation is more accurate, and the economic burden and the physical and psychological burden of a patient can be deepened undoubtedly.
In contrast, the present embodiment provides an artificial blood vessel, specifically: as shown in fig. 1 to 3, the artificial blood vessel comprises a tubular body 1 and a support 2 which can be visualized under X-rays; the wall of the tubular body 1 comprises an inner wall 11 and an outer wall 12, a hollow sandwich cavity 13 is formed between the inner wall 11 and the outer wall 12, and the support 2 is arranged in the sandwich cavity 13.
In some alternative embodiments, as shown in fig. 1, the support 2 comprises a helical support section 21, the helical support section 21 being helically wound outside the inner wall 11 of the tubular body 1; and/or, as shown in fig. 2, the support 2 comprises a plurality of support rings 22 sleeved outside the inner wall 11 of the tubular body 1, and the support rings 22 are spaced from each other along the axial direction of the tubular body 1. Wherein, "and/or" means at least three alternative embodiments:
(1) The support 2 only comprises a spiral support section 21, the spiral support section 21 can be 1 section or multiple sections, when multiple sections are provided, each section of spiral support section 21 is spirally wound outside the inner pipe wall 11, and two adjacent sections of spiral support sections 21 can be mutually spaced or mutually butted;
(2) The support 2 comprises only a plurality of support rings 22 arranged at intervals;
(3) The support 2 includes a spiral support section 21 and a plurality of support rings 22, the spiral support section 21 may be 1 section or multiple sections, and the spiral support section 21 may be interposed between any two support rings 22, or the support rings 22 and the spiral support section 21 are respectively distributed at two ends of the tubular body 1 without being interposed with each other.
In the alternative configuration of the above-described helical support section 21 or of the plurality of support rings 22 of the support 2, none of the support 2 completely obscures the tubular body 1, so that it is possible to provide a plurality of pierceable points during dialysis and, preferably, to make the support 2 itself thinner, preferably designed in thickness, to provide more pierceable points.
Further, there are various alternative structures for the radial cross section of each of the spiral support section 21 and the support ring 22 as the support 2, including, but not limited to, D-shape, circular shape, rectangular shape, etc. as shown in fig. 4 to 6; the tube material of the tubular body 1 may be, but not limited to, one or a combination of several of high molecular materials such as ePTFE (expanded PTFE), TPU (polyurethane), terylene and silica gel, and the function of the support 2 includes supporting the tubular body 1 so that the tubular body 1 maintains a circular radial cross section as much as possible in shape to ensure blood circulation.
In this embodiment, the supporting member 2 capable of being developed under the X-ray is disposed in the interlayer cavity 13 of the tubular main body 1, so that the shape and arrangement mode of the supporting member 2 can be detected through the X-ray after operation, so as to rapidly determine the outline shape of the tubular main body 1 of the artificial blood vessel in the patient, and timely intervene when the artificial blood vessel is changed in shape such as kinking and flattening, so that the problems of difficult puncture, unsmooth flow and scrapping of the whole artificial blood vessel in serious conditions are avoided.
Compared with the traditional artificial blood vessel, the artificial blood vessel provided by the embodiment has the development under X-ray, and the problem can be accurately found through X-ray examination when the self-sense of a patient is not right after operation; the device can also be checked regularly to intervene in time in the possible problems, so that precious treatment time can be strived for, and the device is convenient for patient checking, painless and provides a relatively nondestructive checking means.
In order to develop the whole tubular body 1 as much as possible, the accuracy of the postoperative examination result is increased, and the shape of the tubular body 1 of the artificial blood vessel in the patient is better mastered:
in some alternative implementations of the present embodiment: the support 2 extends from one end in the axial direction of the tubular body 1 to the other end in the axial direction of the tubular body 1, so that each part in the axial direction of the tubular body 1 can be observed by developing with X-rays, and the inspection result is more accurate.
In some alternative implementations of the present embodiment: as shown in fig. 3, the artificial blood vessel further comprises a developing wire 3 which can be developed under the X-ray, the developing wire 3 is also arranged in the interlayer cavity 13, the developing wire 3 is wound on the outer peripheral surface of the inner tube wall 11 of the tubular main body 1, the supporting member 2 is positioned between the developing wire 3 and the inner peripheral surface of the outer tube wall 12 of the tubular main body 1, preferably, the developing wire 3 is wound from one axial end of the tubular main body 1 to the other axial end of the tubular main body 1, and in order to ensure the flexibility of the tubular main body 1 as much as possible, a certain distance is kept between adjacent spiral wires wound on the tubular main body 1 as much as possible by the developing wire 3, and the developing wire 3 can be used without limitation to be a polymer wire containing barium salt and/or bismuth salt and/or other developing components.
Further, with the support member 2 provided in this embodiment, there are at least a variety of optional structures as follows:
in a first type of alternative implementation of the present embodiment: all or part of the support members 2 are each made of tantalum, nickel titanium, platinum iridium or other metallic materials, and are developed by utilizing the developability of the metallic materials themselves.
In a second type of alternative implementation of the present embodiment: all or part of the supporting members 2 each have an inner cavity, the inner cavities of the supporting members 2 are filled with developing materials, the supporting members 2 themselves can be formed by processing and molding high polymer materials such as ePTFE (expanded PTFE), TPU (polyurethane) or FEP (Fluorinated ethylene propylene, fluorinated ethylene propylene copolymer) by injection molding, extrusion or blow molding, and the like, and the developing materials filled in the inner cavities of the supporting members 2 comprise tungsten powder or barium salt and bismuth salt or one or more of tungsten powder or barium salt. Alternatively, all or part of the supports 2 are each made of a mixed material whose composition includes a developing material including one or more of tungsten powder, barium salt and bismuth salt, for example, but not limited to: high molecular materials such as ePTFE (expanded PTFE), TPU (polyurethane) or FEP (Fluorinated ethylene propylene, fluorinated ethylene propylene copolymer) are used as base materials, developing materials such as tungsten powder, barium salt and/or bismuth salt are added in an auxiliary manner to form the mixed materials, and then the mixed materials are processed into the support 2 by means of injection molding, extrusion or blow molding.
In a third class of alternative implementations of the present embodiment: all or part of the outer surfaces of the support 2 are each coated with a developing ink that can be developed under X-rays. Optionally, the main components of the developing ink at least comprise water-based ink and iodine-containing polymer, and the iodine-containing polymer is added into the water-based ink, so that the conventional ink has the characteristic of developing under X-rays, and further the support 2 can be developed, and the developing ink is arranged in the interlayer cavity 13 between the inner wall 11 and the outer wall 12 of the tubular main body 1 along with the support 2, so that the developing ink does not release toxic components into blood during service, and further does not bring any adverse effect to human health due to the ink components. The iodine-containing polymer added to the developing ink may be prepared by, but not limited to, the method of the prior patent (issued bulletin number: CN 114805644B).
In some preferred embodiments of the present embodiment, preferably, the main component of the developing ink may further include a silver-loaded antimicrobial agent, and the specific preparation method of the silver-loaded antimicrobial agent is as follows: (1) Placing a commercial nano zirconium phosphate silver-loaded antibacterial agent (average particle size of 30-50 nm) into an oven, roasting at 100 ℃ for 1 hour, and cooling to room temperature; (2) the antibacterial agent is prepared according to the following weight ratio of 1:10 (mass/volume ratio) soaking, mechanically stirring (stirring rotation speed is not lower than 2000/min, stirring time is not lower than 30 min) to obtain suspension for later use; the preparation method of the developing ink comprises the following steps: (1) Mixing and stirring 1-5% of organic pigment, 40-60% of aqueous acrylic resin liquid, 10-15% of iodine-containing high polymer, 2-8% of organosilicon defoamer, 0.05-2% of anionic dispersant, 10-30% of purified water and 1-10% of silicon dioxide according to weight percentage uniformly to obtain developing ink; (2) Dipping the antibacterial agent suspension by using a glass stirring rod to observe that the antibacterial agent has no small agglomeration, adding the mixed ink of the water-based ink and the iodine-containing polymer while stirring, and fully and uniformly stirring to obtain the antibacterial developing ink; the prepared ink should be preserved in dark.
By such a design, the development ink can be made antimicrobial to avoid or reduce infection of the patient's body tissue when the development ink leaks into the blood under very specific conditions (low probability events).
In the above-described second or third type of alternative implementation of the present embodiment, further alternatively, all or part of the supporting member 2 is made of a high polymer material; and/or the tubular body 1 is made of a polymer material, wherein, preferably, the support 2 and the tubular body 1 of the artificial blood vessel are made of polymer materials, so that the support 2 is tightly attached to the tubular body 1 of the artificial blood vessel, and the dislocation of the support 2 relative to the tubular body 1 of the artificial blood vessel during or after operation is avoided.
In addition, in the operation of establishing a vascular access in a patient by using an artificial blood vessel, in order to ensure that the patient has normal blood flow, a doctor is required to take extra caution during the operation, in order to facilitate the operation of the doctor, in the prior art, an axial ink mark is arranged on the peripheral surface of some artificial blood vessels, the axial ink mark can be observed under the condition of exposure in the operation, the doctor can adjust according to the ink mark, the kink in the operation is effectively prevented, but the ink may be released into the blood of the human body during the operation or the postoperative service period, and thus, some adverse effects are caused on the health of the human body.
In contrast, in the present embodiment, it is preferable that: the outer circumferential surface of the outer wall 12 of the tubular body 1 is further provided with marking lines, as shown in fig. 1 to 3, which comprise axial marking lines 4 extending in the axial direction of the tubular body 1 and/or annular marking lines extending in the circumferential direction of the tubular body 1 and/or net-shaped marking lines wound in the circumferential direction of the tubular body 1, so that the marking lines can be directly observed in an operation, and the doctor can conveniently observe whether the tubular body 1 is twisted and/or flattened in the operation so as to adjust at any time.
Wherein: in some alternative embodiments, the marking line is laser etched into the outer circumferential surface of the tubular body 1.
In other alternative embodiments, the marking lines are ink lines formed by printing ink on the outer peripheral surface of the tubular body 1, and the outer peripheral surface of the outer wall 12 of the tubular body 1 is further covered with a transparent film, which covers the ink lines, and which can protect the ink from penetrating into blood on the one hand and make the ink lines longer lasting on the other hand.
In this alternative embodiment, under the protection of the transparent film, the ink may be a common ink, but preferably, the ink adopts an ink whose main components at least include an aqueous ink and a silver-carrying antibacterial agent, and the specific preparation method of the silver-carrying antibacterial agent is as follows: (1) Placing a commercial nano zirconium phosphate silver-loaded antibacterial agent (average particle size of 30-50 nm) into an oven, roasting at 100 ℃ for 1 hour, and cooling to room temperature; (2) the antibacterial agent is prepared according to the following weight ratio of 1:10 (mass/volume ratio) soaking, mechanically stirring (stirring rotation speed is not lower than 2000/min, stirring time is not lower than 30 min) to obtain suspension for later use; the preparation method of the ink comprises the following steps: (1) Mixing and stirring 1-5% of organic pigment, 40-60% of aqueous acrylic resin liquid, 10-15% of iodine-containing high polymer, 2-8% of organosilicon defoamer, 0.05-2% of anionic dispersant, 10-30% of purified water and 1-10% of silicon dioxide according to weight percentage uniformly to obtain developing ink; (2) Dipping the antibacterial agent suspension by using a glass stirring rod to observe that the antibacterial agent is not agglomerated, adding the antibacterial agent into the water-based ink while stirring, and fully and uniformly stirring to obtain the antibacterial ink; the prepared ink should be preserved in dark. By such a design, the ink can be made antimicrobial to avoid or reduce infection of the patient's body tissue in very special cases (low probability event) when the ink leaks into the blood. For ease of manufacture, the developing ink applied to the outer surface of the support member 2 and the antibacterial ink in this embodiment may be the same ink, that is, the aforementioned antibacterial developing ink, in an alternative structure in which the outer surface of the support member 2 is coated with the developing ink capable of developing under X-rays.
Finally, it should be noted that:
1. in the present specification, "and/or" means "and/or" a preceding structure or component is provided simultaneously or selectively with "and/or" a following structure or component;
2. the artificial blood vessel provided by the specification can be applied to the operation for treating hemodialysis patients, and is also applicable to other operation scenes in which the artificial blood vessel is required to be applied to establish a blood passage in the patients;
3. in the present specification, each embodiment is described in a progressive manner, and each embodiment is mainly described by differences from other embodiments, and identical and similar parts between the embodiments are only required to be seen with each other; the above embodiments in the present specification are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; however, these modifications or substitutions do not deviate the essence of the corresponding technical solutions from the scope of the technical solutions of the embodiments of the present invention, for example, in the present specification, the preparation methods of the developing ink, the antimicrobial developing ink and the antimicrobial ink are only an alternative method, and are not limited thereto, after those skilled in the art obtain the present specification, the developing ink, the antimicrobial developing ink and the antimicrobial ink prepared by adopting other ratios or methods are all within the scope of the technical solutions of the present invention, in addition, in the present specification, several alternative structural forms of the supporting ring are provided, and in actual processing production, it is not necessarily required that all structural forms of the supporting ring are unified, but the supporting rings of the above alternative structures are mixed and arranged at intervals.
Claims (10)
1. An artificial blood vessel, characterized in that: comprising a tubular body (1) and a support (2) developable under X-rays; the pipe wall of the tubular main body (1) comprises an inner pipe wall (11) and an outer pipe wall (12), a hollow interlayer cavity (13) is formed between the inner pipe wall (11) and the outer pipe wall (12), and the supporting piece (2) is arranged in the interlayer cavity (13);
-the support (2) comprises a helical support section (21), the helical support section (21) being helically wound outside the inner tube wall (11) of the tubular body (1); and/or the support piece (2) comprises a plurality of support rings (22) sleeved outside the inner pipe wall (11) of the tubular main body (1), and the support rings (22) are distributed at intervals in the axial direction of the tubular main body (1).
2. The vascular prosthesis of claim 1, wherein: the support member (2) extends from one end in the axial direction of the tubular body (1) to the other end in the axial direction of the tubular body (1);
and/or, the artificial blood vessel further comprises a developing wire (3) capable of being developed under X-rays, the developing wire (3) is arranged in the interlayer cavity (13), the developing wire (3) is wound on the outer peripheral surface of the inner tube wall (11) of the tubular main body (1), and the supporting piece (2) is positioned between the developing wire (3) and the inner peripheral surface of the outer tube wall (12) of the tubular main body (1).
3. The vascular prosthesis of claim 1, wherein: all or part of the supports (2) are each made of a metallic material.
4. The vascular prosthesis of claim 1, wherein: all or part of the supports (2) each have an inner cavity filled with a developing material; alternatively, all or part of the supports (2) are each made of a mixed material whose composition includes a developing material.
5. The vascular prosthesis of claim 4, wherein: the developing material comprises tungsten powder, barium salt and/or bismuth salt.
6. The vascular prosthesis of claim 1, wherein: all or part of the outer surface of the support (2) is coated with a developing ink which is developable under X-rays.
7. The vascular prosthesis of claim 6, wherein: the main components of the developing ink at least comprise water-based ink and iodine-containing polymer.
8. The vascular prosthesis of any one of claims 4 to 7, wherein: all or part of the supporting pieces (2) are respectively made of high polymer materials; and/or the tubular body (1) is made of a polymeric material.
9. The vascular prosthesis of claim 1 or 2, wherein:
the outer peripheral surface of the outer tube wall (12) of the tubular main body (1) is also provided with marking lines, wherein the marking lines comprise axial marking lines (4) extending along the axial direction of the tubular main body (1) and/or annular marking lines extending along the circumferential direction of the tubular main body (1) and/or netlike marking lines wound along the circumferential direction of the tubular main body (1); wherein:
the marking line is laser etched on the outer peripheral surface of the tubular main body (1); or, the marking line is an ink line formed by printing ink on the outer peripheral surface of the tubular main body (1), and the outer peripheral surface of the outer tube wall (12) of the tubular main body (1) is further coated with a transparent film, and the transparent film covers the ink line.
10. The vascular prosthesis of claim 9, wherein: the main components of the ink at least comprise water-based ink and silver-carrying antibacterial agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310848051.9A CN116549171A (en) | 2023-07-12 | 2023-07-12 | Artificial blood vessel |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310848051.9A CN116549171A (en) | 2023-07-12 | 2023-07-12 | Artificial blood vessel |
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| CN116549171A true CN116549171A (en) | 2023-08-08 |
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| CN202310848051.9A Pending CN116549171A (en) | 2023-07-12 | 2023-07-12 | Artificial blood vessel |
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