CN116530680A - Nanoemulsion preparation for protecting eyesight and preparation method and application thereof - Google Patents

Nanoemulsion preparation for protecting eyesight and preparation method and application thereof Download PDF

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Publication number
CN116530680A
CN116530680A CN202310649781.6A CN202310649781A CN116530680A CN 116530680 A CN116530680 A CN 116530680A CN 202310649781 A CN202310649781 A CN 202310649781A CN 116530680 A CN116530680 A CN 116530680A
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nanoemulsion
preparation
lutein
vision protection
carotene
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施小辉
叶佳
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Hangzhou Shangyi Special Medical Biotechnology Co ltd
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Hangzhou Shangyi Special Medical Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Botany (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention provides a nanoemulsion preparation for protecting eyesight, which comprises the following components in parts by weight: lutein ester microcapsule powder 0.01-5.0%, zeaxanthin 0.01-5.0%, carotene 0.01-5.0%, animal and vegetable oil 0.01-5.0%, emulsifying agent 0.1-15.0%, sweetener 0.01-10.0%, and water 55-99.85%. According to the technical scheme, powder containing lutein, lutein ester, zeaxanthin, carotene, wall materials and other raw material mixtures is dispersed and emulsified into a uniform liquid preparation through a special process. Avoiding the problems associated with the need to melt crystals at high temperatures in some lutein formulations. And the problem that lutein, lutein ester and the like are difficult to emulsify is solved by selecting and combining the preparation process and the emulsifier. In addition, the invention also provides a preparation method of the nanoemulsion preparation for vision protection; in addition, the invention also provides a new application of the nanoemulsion preparation for vision protection.

Description

Nanoemulsion preparation for protecting eyesight and preparation method and application thereof
Technical Field
The invention relates to a food health-care product, in particular to a nanoemulsion preparation for protecting eyesight and a preparation method and application thereof.
Background
Lutein ester is a carotenoid fatty acid ester, is a key nutrition element for helping eye development, is applied to various vision protection products, and at present, the lutein is mainly applied in the form of soft capsules and tablets, and the main preparation process generally comprises two steps:
firstly, emulsifying lutein ester to prepare a soft capsule product, for example, chinese patent publication No. CN101869261B discloses a preparation method of water-soluble lutein ester, adding commercially available lutein ester, vegetable oil and antioxidant into a mixing tank according to the weight ratio of 1:2-10:0.01-0.03, heating to 60-90 ℃, stirring and preserving heat for 10-20 min, uniformly mixing to form uniform mixed solution A, adding a hydrating agent preheated to 50-80 ℃ under stirring, preserving heat and stirring for 1h at 55-65 ℃ to obtain mixed solution B, adding a diluting agent preheated to 40-80 ℃ into the mixed solution B, stirring uniformly at 55-65 ℃, and naturally cooling to below 30 ℃ to obtain the stable water-soluble lutein ester. This method can increase the loading of lutein ester in oil, which causes the disadvantage of unstable products; and meanwhile, the degradation risk of lutein ester can be increased by stirring at high temperature.
The other is a process of mixing lutein ester with filling agent, glidant, adhesive, coating agent and the like and then forming tablets by compression molding, and the defects of the process are obvious: firstly, the dissolution speed is low, and the bioavailability is affected; secondly, the Chinese medicinal composition is not suitable for all people and is not easy to be swallowed by children; there is also a serious problem of content drop during storage, compared to the dosage form.
Based on the current state of the art, a lutein ester product which can keep stable, is not easy to degrade, and can improve the taste and the using convenience is lacking at present.
Disclosure of Invention
In view of the above-mentioned drawbacks of the prior art, the present invention aims to provide a nanoemulsion formulation for vision protection, which is used for solving the problem that the prior art lacks a lutein ester product which can not only keep the stability of lutein ester products, but also can improve the mouthfeel and the convenience of use, and at the same time, the present invention also provides a preparation method of the nanoemulsion formulation for vision protection; in addition, the invention also provides a new application of the nanoemulsion preparation for vision protection.
To achieve the above-mentioned objects and other related objects,
in a first aspect of the invention, a nanoemulsion formulation for vision protection is provided, comprising the following components in parts by weight: lutein ester microcapsule powder 0.01-5.0%, zeaxanthin 0.01-5.0%, carotene 0.01-5.0%, animal and vegetable oil 0.01-5.0%, emulsifying agent 0.1-15.0%, sweetener 0.01-10.0%, and water 55-99.85%.
By the technical scheme, lutein ester and zeaxanthin are carotenoid, are very important to the health of eyes, and have an antioxidation effect; the carotene is a vitamin A supplement and has the effects of protecting eyesight, resisting oxidation and the like; meanwhile, carotenoids and carotenes have complementary effects in the absorption process; the vitamin A has the main functions of maintaining eyesight and resisting oxidation in human body; in addition, the addition of fatty acids and carotenoids to the perfusate can significantly increase vitamin a concentration in the mouse serum, as unsaturated fatty acids can stimulate bile secretion, and act as carriers for carotenoids during emulsification of esters to promote carotenoid absorption.
In an embodiment of the invention, the animal and vegetable oil is any one or a combination of several of olive oil, maize germ oil, soybean oil and fish oil; the animal and vegetable oil accounts for 0.1-1.0% of the weight of the total weight of the oil.
By the technical scheme, in practical application, the animal and vegetable oil is preferably olive oil meeting the standard GB 2760.
In an embodiment of the invention, the emulsifier is one or a combination of more than one of soybean lecithin, egg yolk lecithin, liquid phospholipid, span and mono-diglyceride; the weight portion of the emulsifier is 0.5% -2.0%.
Through the technical scheme, in practical application, the emulsifier is preferably egg yolk lecithin meeting the standard GB 2760.
In an embodiment of the present invention, the sweetener is one or a combination of several of glucose, sucralose, stevioside, sucrose, lactose, and xylitol; the weight portion of the sweetener is 5.0% -10.0%.
Through the technical scheme, in practical application, the sweetener is preferably glucose meeting the standard GB 2760.
In an embodiment of the invention, the lutein ester microcapsule powder is 0.1% -1.0% by weight.
Through the technical scheme, the lutein ester microcapsule powder is lutein ester microcapsule powder meeting the standard of new resource food announcements.
In one embodiment of the invention, the zeaxanthin is in an amount of 0.01% -0.5% by weight.
By the technical scheme, the zeaxanthin accords with the standard new resource food notice.
In an embodiment of the invention, the weight portion of the carotene is 0.01% -0.5%.
Through the technical scheme, the carotene is carotene meeting the standard GB 28310.
In one embodiment of the invention, the nanoemulsion particle size of lutein, lutein esters, zeaxanthin, carotene and the like is less than 1000nm.
In a second aspect of the present invention, there is provided a method of preparing the nanoemulsion formulation for vision protection, comprising the steps of:
s1, mixing and shearing a certain weight part of zeaxanthin, carotene, egg yolk lecithin and glucose to obtain a water phase mixed solution, adding olive oil into the water phase mixed solution, and mixing and shearing to obtain colostrum;
s2, homogenizing the colostrum obtained in the step S1 under high pressure to obtain an intermediate; wherein, the pressure range of high-pressure homogenization is 300-1000 MPa, and the homogenization temperature range is 50-60 ℃;
s3, adding a certain weight part of lutein microcapsule powder into the intermediate obtained in the step S2, mixing and shearing until the mixture is uniform, and obtaining nano emulsion;
and S4, sterilizing the nano emulsion obtained in the step S4.
In a third aspect, the invention provides an application of the nanoemulsion preparation for vision protection in the aspect of food preparation and health care products.
As described above, the nanoemulsion formulation for vision protection and the preparation method and application thereof of the present invention have the following beneficial effects:
1. the nanoemulsion preparation is finally prepared, and the problems that raw materials and animal and vegetable oil are poor in taste, difficult to directly absorb and poor in stability when being directly eaten are solved; secondly, because of the oil-in-water particles formed after the water phase and the oil phase are mixed, the stability of the preparation is improved; meanwhile, the nano emulsion can be prepared into an oral liquid dosage form, and the absorption of lutein ester, zeaxanthin, carotene and animal and vegetable oil by a human body is greatly improved through oral administration.
2. The nano-emulsion particles are uniformly dispersed, the particle size reaches the nano-scale, and the nano-emulsion has good stability, so that the nano-emulsion can better protect the raw materials and the effective components of animal and vegetable oil from being influenced by environmental factors, and further, oxidation products harmful to human bodies can not be generated. And the smaller particles can improve the bioavailability to a certain extent.
3. The nanoemulsion has the following advantages: 1. the dispersity is very high, and the absorption and the effect are very fast; 2. the bioavailability is high; 3. the permeability to skin mucous membrane is improved, and the stimulation is reduced; 4. fast distribution, high effect, nano-level grain size, good stability, good taste, convenient eating, etc. Is suitable for various people, and has certain effects in protecting eyesight, delaying the increase of myopia degree and preventing the injury of computer radiation to human body.
Detailed Description
Further advantages and effects of the present invention will become apparent to those skilled in the art from the disclosure of the present invention, which is described by the following specific examples.
Example 1
The nanoemulsion preparation for protecting eyesight comprises the following components in parts by weight: lutein ester microcapsule powder 1.0%, zeaxanthin 0.5%, carotene 0.5%, animal and vegetable oil 1.0%, emulsifying agent 0.1%, sweetener 5.0%, and water 91.9%.
Wherein the animal and vegetable oil is one or more of olive oil, maize germ oil, soybean oil, olive oil and fish oil, and in the embodiment, the preferred one is olive oil conforming to the standard GB 2760; the emulsifier is one or more of soybean lecithin, egg yolk lecithin, liquid phospholipid, span, and mono-diglycerol fatty acid ester, and in this embodiment, egg yolk lecithin meeting standard GB2760 is preferable; the sweetener is one or more of glucose, sucralose, stevioside, sucrose, lactose, and xylitol, and in this embodiment, glucose meeting standard GB2760 is preferred.
Specifically, the nanoemulsion particle size of lutein, lutein ester, zeaxanthin, carotene and the like is smaller than 1000nm.
The preparation method of the nanoemulsion preparation for protecting eyesight comprises the following steps:
s1, mixing and shearing a certain weight part of zeaxanthin, carotene, egg yolk lecithin and glucose to obtain a water phase mixed solution, adding olive oil into the water phase mixed solution, and mixing and shearing to obtain colostrum;
s2, homogenizing the colostrum obtained in the step S1 under high pressure to obtain an intermediate; wherein, the pressure range of high-pressure homogenization is 300-1000 MPa, and the homogenization temperature range is 50-60 ℃;
s3, adding a certain weight part of lutein microcapsule powder into the intermediate obtained in the step S2, mixing and shearing until the mixture is uniform, and obtaining nano emulsion;
and S4, sterilizing the nano emulsion obtained in the step S4.
Example 2
The nanoemulsion preparation for protecting eyesight comprises the following components in parts by weight: lutein ester microcapsule powder 1.0%, zeaxanthin 0.5%, carotene 0.5%, animal and vegetable oil 1.0%, emulsifying agent 0.1%, sweetener 5.0%, and water 91.9%.
Wherein the animal and vegetable oil is olive oil conforming to the standard GB2760, the emulsifying agent is soybean lecithin, and the sweetener is glucose conforming to the standard GB 2760.
Specifically, the nanoemulsion particle size of lutein, lutein ester, zeaxanthin, carotene and the like is smaller than 1000nm.
Example 3
The nanoemulsion preparation for protecting eyesight comprises the following components in parts by weight: lutein ester microcapsule powder 1.0%, zeaxanthin 0.5%, carotene 0.5%, animal and vegetable oil 1.0%, emulsifying agent 0.1%, sweetener 5.0%, and water 91.9%.
Wherein the animal and vegetable oil is maize germ oil meeting the standard, the emulsifying agent is soybean lecithin, and the sweetener is glucose meeting the standard GB 2760.
Specifically, the nanoemulsion particle size of lutein, lutein ester, zeaxanthin, carotene and the like is smaller than 1000nm.
Example 4
The nanoemulsion preparation for protecting eyesight comprises the following components in parts by weight: lutein ester microcapsule powder 1.0%, zeaxanthin 0.5%, carotene 0.5%, animal and vegetable oil 1.0%, emulsifying agent 0.1%, sweetener 5.0%, and water 91.9%.
Wherein the animal and vegetable oil is olive oil conforming to the standard GB2760, the emulsifying agent is soybean lecithin, and the sweetener is sucralose conforming to the standard.
Specifically, the nanoemulsion particle size of lutein, lutein ester, zeaxanthin, carotene and the like is smaller than 1000nm.
And S4, sterilizing the nano emulsion obtained in the step S4.
Example 5
The nanoemulsion preparation for protecting eyesight comprises the following components in parts by weight: lutein ester microcapsule powder 0.01%, zeaxanthin 0.01%, carotene 0.01%, animal and vegetable oil 0.01%, emulsifying agent 0.1%, sweetener 5.0%, and water 94.86%.
Wherein the animal and vegetable oil is olive oil conforming to the standard GB 2760; the emulsifier is egg yolk lecithin conforming to the standard GB 2760; the sweetener is glucose meeting the standard GB 2760.
Specifically, the nanoemulsion particle size of lutein, lutein ester, zeaxanthin, carotene and the like is smaller than 1000nm.
Example 6
The nanoemulsion preparation for protecting eyesight comprises the following components in parts by weight: lutein ester microcapsule powder 1.0%, zeaxanthin 0.5%, carotene 0.5%, animal and vegetable oil 1.0%, emulsifying agent 2.0%, sweetener 10.0%, and water 85%.
Wherein the animal and vegetable oil is olive oil conforming to the standard GB 2760; the emulsifier is egg yolk lecithin conforming to the standard GB 2760; the sweetener is glucose meeting the standard GB 2760.
Specifically, the nanoemulsion particle size of lutein, lutein ester, zeaxanthin, carotene and the like is smaller than 1000nm.
Example 7
The nanoemulsion preparation for protecting eyesight comprises the following components in parts by weight: lutein ester microcapsule powder 5.0%, zeaxanthin 5.0%, carotene 5.0%, animal and vegetable oil 5.0%, emulsifying agent 15.0%, sweetener 10.0%, and water 55%.
Wherein the animal and vegetable oil is olive oil conforming to the standard GB 2760; the emulsifier is egg yolk lecithin conforming to the standard GB 2760; the sweetener is glucose meeting the standard GB 2760.
Specifically, the nanoemulsion particle size of lutein, lutein ester, zeaxanthin, carotene and the like is smaller than 1000nm.
Example 8
The application of the nanoemulsion preparation for protecting eyesight in the aspect of preparing foods and health-care products.
Data detection
(1) Characteristic test
The nanoemulsion formulations for vision protection prepared in examples 1 to 4 were tested for pH, particle size and Zeta potential, and the test data are shown in table 1 below.
TABLE 1
From the above table 1, it can be seen that the nanoemulsion preparation obtained after the present invention has high absolute value of potential, correspondingly good stability, and large amount of active ingredient, and further improves the bioavailability due to its smaller particle size, and can be dissolved with milk, beverage, etc. at will, so that the nanoemulsion preparation for vision protection prepared by the examples has the best effect.
That is, the effect of egg yolk lecithin in the emulsifier is optimal, the effect of olive oil in the animal and vegetable oil is optimal, and the effect of glucose in the sweetener is optimal.
(2) Clinical trial
Clinical tests were performed on the nanoemulsion preparation for vision protection prepared in example 1, wherein the number of medical records in the clinical test was 80, and 40 blank control groups were set, and the blank control groups used the nanoemulsion conventional in the art, and the time period of the products used in the clinical groups and the control groups was two months.
The Best Corrected Vision (BCVA) examination of the control and clinical groups is shown in table 2.
Table 2 two different sets of time BCVA statistics
Group of Quantity of Before treatment One month after treatment Two months after treatment
Control group 40 0.07±0.01 0.12±0.05 0.16±0.02
Clinical group 40 0.07±0.02 0.23±0.01 0.28±0.02
As can be seen from the table, the clinical group taking the nanoemulsion preparation for vision protection prepared by the invention and the control group taking the conventional nanoemulsion preparation in the field are improved compared with the BCVA before treatment, but the vision improvement condition of the clinical group is more remarkable.
In addition, the improvement of the clinical manifestations of the control group and the clinical group is counted, and the specific results are shown in Table 3.
Table 3 two sets of pre-and post-treatment symptom statistics
Group of Quantity of Eye pain Eye dryness Blurred vision
Control group 40 6(15％) 16(40％) 5(12.5％)
Clinical group 40 2(5％) 2(5％) 1(2.5％)
As can be seen from the table above, the clinical group had significantly improved symptoms before and after treatment, and had lower incidence of eye pain, dry eyes and blurred vision than the control group.
In conclusion, the nanoemulsion preparation is finally prepared, and the problems that raw materials and animal and vegetable oil are poor in taste, difficult to directly absorb and poor in stability when being directly eaten are solved; secondly, because of the oil-in-water particles formed after the water phase and the oil phase are mixed, the stability of the preparation is improved; meanwhile, the nano emulsion can be prepared into an oral liquid dosage form, and the absorption of lutein ester, zeaxanthin, carotene and animal and vegetable oil by a human body is greatly improved through oral administration. Therefore, the invention effectively overcomes various defects in the prior art and has high industrial utilization value.
The above embodiments are merely illustrative of the principles of the present invention and its effectiveness, and are not intended to limit the invention. Modifications and variations may be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the invention. Accordingly, it is intended that all equivalent modifications and variations of the invention be covered by the claims, which are within the ordinary skill of the art, be within the spirit and scope of the present disclosure.

Claims (10)

1. The nanoemulsion preparation for protecting eyesight is characterized by comprising the following components in parts by weight: lutein ester microcapsule powder 0.01-5.0%, zeaxanthin 0.01-5.0%, carotene 0.01-5.0%, animal and vegetable oil 0.01-5.0%, emulsifying agent 0.1-15.0%, sweetener 0.01-10.0%, and water 55-99.85%.
2. Nanoemulsion formulation for vision protection according to claim 1, characterized in that: the animal and vegetable oil is one or a combination of more of olive oil, maize germ oil, soybean oil and fish oil; the animal and vegetable oil accounts for 0.1-1.0% of the weight of the total weight of the oil.
3. Nanoemulsion formulation for vision protection according to claim 1, characterized in that: the emulsifier is one or a combination of more than one of soybean lecithin, egg yolk lecithin, liquid phospholipid, span and mono-diglycerol fatty acid ester; the weight portion of the emulsifier is 0.5% -2.0%.
4. Nanoemulsion formulation for vision protection according to claim 1, characterized in that: the sweetener is one or a combination of more of glucose, sucralose, stevioside, sucrose, lactose and xylitol; the weight portion of the sweetener is 5.0% -10.0%.
5. Nanoemulsion formulation for vision protection according to claim 1, characterized in that: the lutein ester microcapsule powder is 0.1% -1.0% by weight.
6. Nanoemulsion formulation for vision protection according to claim 1, characterized in that: the weight portion of the zeaxanthin is 0.01% -0.5%.
7. Nanoemulsion formulation for vision protection according to claim 1, characterized in that: the weight portion of the carotene is 0.01% -0.5%.
8. Nanoemulsion formulation for vision protection according to claim 1, characterized in that: the nanoemulsion particle size of the lutein, lutein ester, zeaxanthin, carotene and the like is smaller than 1000nm.
9. A method of preparing a nanoemulsion formulation for vision protection according to any one of claims 1-8, comprising the steps of:
s1, mixing and shearing a certain weight part of zeaxanthin, carotene, egg yolk lecithin and glucose to obtain a water phase mixed solution, adding olive oil into the water phase mixed solution, and mixing and shearing to obtain colostrum;
s2, homogenizing the colostrum obtained in the step S1 under high pressure to obtain an intermediate; wherein, the pressure range of high-pressure homogenization is 300-1000 MPa, and the homogenization temperature range is 50-60 ℃;
s3, adding a certain weight part of lutein microcapsule powder into the intermediate obtained in the step S2, mixing and shearing until the mixture is uniform, and obtaining nano emulsion;
and S4, sterilizing the nano emulsion obtained in the step S4.
10. Use of a nanoemulsion formulation for vision protection according to any one of claims 1-4, for the preparation of food and health care products.
CN202310649781.6A 2023-06-02 2023-06-02 Nanoemulsion preparation for protecting eyesight and preparation method and application thereof Pending CN116530680A (en)

Priority Applications (1)

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CN202310649781.6A CN116530680A (en) 2023-06-02 2023-06-02 Nanoemulsion preparation for protecting eyesight and preparation method and application thereof

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Application Number Priority Date Filing Date Title
CN202310649781.6A CN116530680A (en) 2023-06-02 2023-06-02 Nanoemulsion preparation for protecting eyesight and preparation method and application thereof

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Publication Number Publication Date
CN116530680A true CN116530680A (en) 2023-08-04

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Application publication date: 20230804