CN116519691A - High-flux cell chromosome image analyzer - Google Patents
High-flux cell chromosome image analyzer Download PDFInfo
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- CN116519691A CN116519691A CN202310557380.8A CN202310557380A CN116519691A CN 116519691 A CN116519691 A CN 116519691A CN 202310557380 A CN202310557380 A CN 202310557380A CN 116519691 A CN116519691 A CN 116519691A
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- 210000000349 chromosome Anatomy 0.000 title claims abstract description 30
- 238000007599 discharging Methods 0.000 claims abstract description 8
- 229910000831 Steel Inorganic materials 0.000 claims description 54
- 239000010959 steel Substances 0.000 claims description 54
- 238000012545 processing Methods 0.000 claims description 4
- 238000010191 image analysis Methods 0.000 claims description 3
- 230000003068 static effect Effects 0.000 claims description 3
- 230000007704 transition Effects 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 230000004907 flux Effects 0.000 claims description 2
- 239000011521 glass Substances 0.000 abstract description 22
- 238000003384 imaging method Methods 0.000 abstract description 3
- 238000000926 separation method Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000012423 maintenance Methods 0.000 description 4
- 108010077544 Chromatin Proteins 0.000 description 3
- 210000003483 chromatin Anatomy 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000004075 alteration Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000016507 interphase Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- 239000000981 basic dye Substances 0.000 description 1
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- 230000000903 blocking effect Effects 0.000 description 1
- 210000000078 claw Anatomy 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
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- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000035773 mitosis phase Effects 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
- B65G1/00—Storing articles, individually or in orderly arrangement, in warehouses or magazines
- B65G1/02—Storage devices
- B65G1/04—Storage devices mechanical
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
- B65G1/00—Storing articles, individually or in orderly arrangement, in warehouses or magazines
- B65G1/02—Storage devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
- B65G47/00—Article or material-handling devices associated with conveyors; Methods employing such devices
- B65G47/74—Feeding, transfer, or discharging devices of particular kinds or types
- B65G47/82—Rotary or reciprocating members for direct action on articles or materials, e.g. pushers, rakes, shovels
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The application relates to a high-throughput cell chromosome image analyzer, which comprises a slide cabin, a slide box, a slide loading and unloading device, a microscope and an electrical cabinet, wherein the slide cabin is used for storing the slide box, the slide box is used for installing a slide, the slide loading and unloading device is used for taking the slide box out of the slide cabin and placing the slide box on the microscope or taking the slide box on the microscope down and placing the slide box in the slide cabin, the microscope is used for carrying out imaging treatment on a slide on the slide box, and the electrical cabinet is used for controlling the slide loading and unloading device and the microscope to work orderly; the push-pull part is arranged to realize loading and unloading of the glass slide box in a push-pull mode, one end of the push-pull part is designed to be flat, the space of the longitudinal arrangement of the glass slide box is not occupied, and the structure can be more compact; furthermore, the feeding and discharging are realized only through pushing and pulling actions, the steps are simple, and the working efficiency is high.
Description
Technical Field
The application relates to the technical field of slide storage and transportation, in particular to a high-flux cell chromosome image analyzer.
Background
Chromosomes are polymers formed by deep compression of genetic materials with genetic properties in cells, and are easy to dye into dark colors by basic dyes, so the chromosomes (consisting of chromatin); chromosome and chromatin are different morphological manifestations of the same substance in the interphase and in the mitosis phase of a cell. Chromosomes appear in the dividing phase. Chromatin appears in interphase, in the form of filaments. The chromosome image analysis system is a common chromosome nuclear type analysis tool and consists of a three-eye microscope, a video camera, chromosome image analysis software, a computer, a printer and the like. The chromosome smear manufactured by the conventional method is placed under a microscope for observation, the image under the microscope is transmitted into a computer in real time by adopting a computer image processing technology, and the chromosome image is observed, collected, analyzed and processed on a computer screen, so that the chromosome smear has the advantages of intuitiveness, high efficiency and simplicity, can greatly lighten the labor intensity of medical workers, can store and process medical records, and is the trend of medical microscopic image analysis.
At present, for Chinese patent with publication number of CN112557392A, an intelligent chromosome nuclear type analyzer is disclosed, which integrates all the constituent structures together, and through an automatic design, the full-automatic operation of transferring from a slide, imaging the slide and storing the slide is realized, and only the manual participation in the replacement of the slide box is needed in the whole process;
however, the transfer of the slides used therein employs a gripper module to remove the slides from the magazine and place them on the microscope platform, which has some problems: 1) Firstly, a space is reserved for a claw part for clamping a slide glass in the design of the slide glass bin, at the moment, the arrangement distance between upper and lower slide glass can be limited, and the slide glass bin cannot obtain more compact arrangement of the slide glass, so that more slide glass cannot be put in; 2) The transferring slide adopts a mode of clamping and rotating, so that the steps are complicated, for example, the feeding process generally needs to be carried out through four steps of clamping, taking out, rotating and putting down, and the structure cannot improve the working efficiency.
Disclosure of Invention
In order to solve the defects that the existing slide bin needs to be matched with a manipulator, the structure is not compact, and the slide transferring steps are complicated, the application provides a high-flux cell chromosome image analyzer.
The high-flux cell chromosome image analyzer provided by the application adopts the following technical scheme:
this high flux cell chromosome image analyzer, including slide storehouse, slide case, slide go up unloader, microscope and electrical apparatus cabinet, slide storehouse is used for storing the slide case, the slide case is used for installing the slide, unloader is used for with the slide case follow in the slide storehouse take out place on the microscope or with slide case on the microscope is taken off and is put into in the slide storehouse, the microscope is used for carrying out the formation of image processing to the slide on the slide case, electrical apparatus cabinet is used for controlling unloader and microscope work in order on the slide. The slide bin comprises a bin body with front and rear through openings, and grooves for installing slide boxes are uniformly formed in the inner walls of the two sides of the bin body; the slide feeding and discharging device comprises an X-direction linear module and a Z-direction linear module, wherein the static part of the Z-direction linear module is connected with the moving part of the X-direction linear module, and the moving part of the Z-direction linear module is connected with the push-pull part; the microscope comprises a microscope platform for placing the slide boxes, the push-pull part is used for pushing the slide boxes of each layer in the bin body onto the microscope platform and/or pulling the slide boxes on the microscope platform back into corresponding grooves in the bin body, and one end of the push-pull part, which is propped against the slide boxes, is flat.
By adopting the technical scheme: the slide boxes are stored in the slide bin, the slide boxes are loaded and unloaded in a manner of being pushed and pulled by the push-pull part, the push-pull ends of the push-pull parts are arranged to be flat, and the flat push-pull parts cannot occupy the longitudinal space in the bin, so that the slide boxes can be more closely arranged together, the obtained arrangement of the slide boxes is more compact, and more slide boxes can be put in; meanwhile, the push-pull part is adopted for feeding and discharging, and the feeding and discharging are realized only through pushing and pulling actions, so that the steps are simple, and the working efficiency is high.
The storehouse body includes bottom plate and roof, is connected with two curb plates between bottom plate and the roof, wherein at least one the curb plate is located one side of push-and-pull portion and is provided with the setting element, setting element and recess one-to-one.
By adopting the technical scheme: the locating piece can provide and block or restrict when drawing back the slide box, avoids the slide box to pull through dropping, also avoids the accurate distance of pulling of portion design that need to push-and-pull, reduces the programming.
A pull handle is arranged on one side of the front end of the slide box, and a pushing surface corresponding to the push-pull part is arranged at the front end of the pull handle.
By adopting the technical scheme: the glass box is provided with a handle so as to be matched with the push-pull part to realize loading and unloading.
The microscope platform is provided with a U-shaped groove, one side of the U-shaped groove is provided with a notch which opens to two sides, the slide box is pushed into the U-shaped groove in parallel by the push-pull part from the notch, the notch adopts arc transition, and the groove width of the U-shaped groove is slightly larger than the width of the slide box; be equipped with the limit structure who is used for fixed slide box on the U type groove, limit structure includes first magnet steel and first steel sheet, the edge in U type groove is equipped with the angular slot that is used for slide box direction to support, first magnet steel distributes on the horizontal terminal surface in angular slot, and the bottom of slide box is buried in first steel sheet and with first magnet steel attracts mutually.
By adopting the technical scheme: set up the U type groove, push the slide box into the inslot just can guarantee the location, and inhale mutually through first steel sheet and first magnet steel and realize the fixed of slide box in the U type groove, location and fixed go on simultaneously, efficient.
The push-pull part comprises an L-shaped rod, one longer end of the L-shaped rod is propped against the push surface, the end of the L-shaped rod is also provided with a pull block, and the pull block is arranged on the side surface of the L-shaped rod and is in an integrated structure with the L-shaped rod.
By adopting the technical scheme: the L-shaped rod is used for realizing push-pull work and is matched with the X-direction linear module and the Z-direction linear module, so that the push-pull part is vertically abutted against the push surface.
The bottom of the bin body is provided with a lifting platform, at least one second magnetic steel and at least two positioning columns are arranged on the lifting platform, and the bottom end of the bin body is provided with a second steel sheet interacted with the second magnetic steel and a positioning groove corresponding to the positioning columns.
By adopting the technical scheme: the slide boxes of all layers in the slide bin can be flush with the microscope platform by arranging the lifting platform, and the slide bin can be stably arranged on the lifting platform by arranging the second magnetic steel and the positioning column.
The automatic glass slide feeding device comprises a glass slide bin, a glass slide feeding device, a glass microscope, an electric cabinet and a glass slide feeding device, and is characterized by further comprising a box body, wherein the glass slide bin, the glass slide feeding device, the glass microscope and the electric cabinet are all installed in the box body, an opening corresponding to the glass slide bin is arranged on the side face of the box body, and handles are connected to a side plate and a top plate, which are close to one side of the opening, of the glass slide bin.
By adopting the technical scheme: the box body is arranged and used for preventing dust, the opening is arranged and used for placing the slide bin, and the top end and one side of the slide bin are provided with handles, so that the slide bin is convenient to take from the side face and the top.
The microscope also comprises a microscope lens and an oil dripping device, a notch for exposing the microscope lens is reserved on the box body, an upper lifting cover is arranged on one side of the top of the box body, a gas spring is connected between the upper lifting cover and the inner wall of the box body, and the upper lifting cover is connected with the box body through a lock body.
By adopting the technical scheme: the upper lifting cover is arranged for overhauling, and the gas spring is arranged for supporting when the cover is opened.
The box is close to microscope one side and can dismantle and be connected with the blade, blade and box side pass through bolt fixed connection.
By adopting the technical scheme: the blade plate can be completely taken down during maintenance, and the operation is convenient.
The slide box is characterized in that a limiting structure is arranged in the groove and comprises third magnetic steel and third steel sheets, the third magnetic steel sheets are embedded in the groove, and the third steel sheets are arranged on two sides of the slide box and are matched with the third magnetic steel sheets.
By adopting the technical scheme: the third magnetic steel and the third steel sheet are arranged to form a viscous effect, so that the slide box is prevented from sliding from the side where the spring baffle is not arranged.
In summary, the present application includes the following beneficial effects:
1. the push-pull part is arranged to realize loading and unloading of the glass slide box in a push-pull mode, one end of the push-pull part is designed to be flat, the space of the longitudinal arrangement of the glass slide box is not occupied, and the structure can be more compact; furthermore, the feeding and discharging are realized only through pushing and pulling actions, the steps are simple, and the working efficiency is high.
2. The cost of slide box and platform counterpoint is reduced through setting up the opening, utilizes push-and-pull portion directly to push in the U type groove with the slide box just can realize the location, and has the limit structure that can viscous stay in the U type groove for it is more convenient to go up the unloading, snatchs, the production rhythm of putting down for the manipulator, and push-and-pull produced effect is better.
Drawings
FIG. 1 is a schematic structural view of embodiment 1 in the present application;
FIG. 2 is a schematic view of the structure of the slide magazine and lift platform of FIG. 1;
FIG. 3 is a schematic rear view of the bottom view of the slide magazine of the present application;
fig. 4 is a schematic view of the rear face of the slide magazine of fig. 3;
FIG. 5 is an enlarged schematic view of the structure shown at A in FIG. 1;
FIG. 6 is an enlarged schematic view of the structure shown at B in FIG. 4;
FIG. 7 is a schematic view of the structure of the microscope platform and slide cassette of the present application;
FIG. 8 is a schematic view of the embodiment 2 of the present application with the flip-up lid opened;
fig. 9 is a schematic view of the lid of embodiment 2 of the present application.
Reference numerals illustrate: 1. a case; 101. a door body; 102. a blade; 1021. a small door; 2. lifting the cover; 3. an electric appliance cabinet; 4. an X-direction linear module; 5. a Z-direction linear module; 6. a slide bin; 601. a second steel sheet; 602. a positioning groove; 603. a groove; 6031. a third magnetic steel; 7. an L-shaped rod; 701. pulling blocks; 8. an oil dripping device; 801. an oil storage pipe; 9. a microscope lens; 10. a microscope platform; 1001. a U-shaped groove; 1002. an angular groove; 1003. a notch; 1004. a first magnetic steel; 11. a glass slide box; 1101. a handle; 1102. a first steel sheet; 1103. a third steel sheet; 11011. pushing the dough; 12. a control box; 13. heightening a platform; 14. a lifting platform; 1401. a second magnetic steel; 1402. positioning columns; 1403. a proximity switch; 15. a spring catch; 16. a handle.
Detailed Description
The present application is described in further detail below in conjunction with fig. 1.
The embodiment of the application discloses a high-flux cell chromosome image analyzer.
Example 1:
referring to fig. 1, the high-throughput cell chromosome image analyzer comprises a slide bin 6, a slide box 11, a slide loading and unloading device, a microscope and an electrical cabinet 3, wherein the slide bin 6 is used for storing the slide box 11, the slide box 11 is used for installing a slide, the slide loading and unloading device is used for taking the slide box 11 out of the slide bin 6 and placing the slide box 11 on the microscope or taking the slide box 11 on the microscope into the slide bin 6, the microscope is used for imaging and processing the slide on the slide box 11, and the electrical cabinet 3 is used for controlling the slide loading and unloading device and the microscope to work orderly.
The slide box 11 is placed in the bin body, and only two side plates are used for limiting; meanwhile, the slide feeding and discharging device comprises an X-direction linear module 4 and a Z-direction linear module 5, wherein the static part of the Z-direction linear module 5 is connected with the moving part of the X-direction linear module 4, the moving part of the Z-direction linear module 5 is connected with a push-pull part, the X-direction linear module 4 is used for driving the push-pull part to move along the horizontal direction, the Z-direction linear module 5 is used for driving the push-pull part to move along the vertical direction, and through the cooperation of the two linear modules, the push-pull part can be used for feeding and discharging, and pushes slide boxes 11 of each layer in a bin body into a microscope platform 10 and pulls the slide boxes 11 on the microscope platform 10 back into corresponding grooves 603 in the bin body; in the embodiment, the X-direction linear module 4 and the Z-direction linear module 5 are screw rod modules with the model number of GTH 4-L2-100-BC-M10B-C4; in another embodiment, the push-pull portion may be used only for loading, which may push the slide cassettes 11 of the layers in the magazine body onto the microscope platform 10; in another embodiment, the push-pull portion may be used only for blanking, and may pull the slide cassette 11 on the microscope platform 10 back into the corresponding groove 603 in the bin body, so as to reduce the longitudinal gap of the arrangement of the slide cassette in the bin body, and one end of the push-pull portion abutting against the slide cassette 11 is flat.
In this embodiment, the microscope further includes a microscope lens 9, an oil dropping device 8, and a microscope platform 10 for placing the slide box 11, where the microscope platform 10 is disposed below the microscope lens 9 so that the microscope lens 9 observes the slide, referring to fig. 7, a U-shaped groove 1001 is disposed on the microscope platform 10, a notch 1003 opening to two sides is disposed on one side of the U-shaped groove 1001, the slide box 11 is pushed into the U-shaped groove 1001 from the notch 1003 by the push-pull portion in parallel, the notch 1003 adopts arc transition so that the slide box 11 can be pushed into the U-shaped groove 1001 smoothly, and the alignment cost is reduced, so that the slide box 11 can be installed into the U-shaped groove 1001 and a certain guiding effect can be played for the slide box 11, and the groove width of the U-shaped groove 1001 is slightly larger than that of the slide box 11; in order to make the detection of microscope more accurate, be equipped with the limit structure that is used for fixing slide box 11 on the U type groove 1001 so that slide box 11 is fixed a position after inserting U type groove 1001, this limit structure includes first magnet steel 1004 and first steel sheet 1102, the edge in U type groove 1001 is equipped with the angle groove 1002 that the opening up, this angle groove 1002 is used for slide box 11 direction to support, first magnet steel 1004 buries on the horizontal terminal surface of angle groove 1002 evenly, the bottom of slide box 11 buries first steel sheet 1102 and corresponds with the position of first magnet steel 1004 after slide box 11 inserts U type groove 1001, first steel sheet 1102 and first magnet steel 1004 inhale the location that realizes slide box 11 this moment.
Specifically, the bin body in this embodiment includes bottom plate and roof, be connected with two curb plates between bottom plate and the roof, wherein one side that at least one curb plate is located push-and-pull portion is provided with the setting element, this setting element is spring separation blade 15, the quantity of spring separation blade 15 is unanimous with the internal quantity of placing slide box 11 in bin, and spring separation blade 15 and recess 603 are the one-to-one, spring separation blade 15 can provide and block or restrict when slide box 11 is pulled back, avoid slide box 11 to pull through dropping, slide box 11 pull back to with spring separation blade 15 offset just can confirm the position of slide box 11 in the bin body.
Referring to fig. 4 and 6, in order to prevent the slide box 11 from sliding from the side where the spring blocking piece 15 is not provided, a limiting structure is arranged in the groove 603, the limiting structure adopts a third magnetic steel 6031 and a third steel sheet 1103 to form a viscous effect, the third magnetic steel 6031 is embedded in the groove 603, and the third steel sheet 1103 is arranged at two sides of the slide box 11 and matched with the third magnetic steel 6031.
Referring to fig. 5 and 7, in order to match the push-pull portion, a pull tab 1101 is provided on a front end side of the slide cassette 11, and a push surface 11011 corresponding to the push-pull portion is provided on a front end of the pull tab 1101; the push-pull part comprises an L-shaped rod 7, one longer end of the L-shaped rod 7 is propped against the push surface 11011, the end of the L-shaped rod 7 is also provided with a pull block 701, and the pull block 701 is arranged on the side surface of the L-shaped rod 7 and is in an integral structure with the L-shaped rod 7.
Example 2:
referring to fig. 8 and 9, this embodiment differs from embodiment 1 in that: for beautiful appearance and realizing dustproof, still include box 1, slide storehouse 6, unloader on the slide, microscope and electrical cabinet 3 are all installed in box 1, refer to the picture, be equipped with two regions about in the box 1, the top of microscope is equipped with and increases platform 13, it is used for installing the dedicated control box 12 of microscope to increase platform 13, microscope and control box 12 are all installed in left side region, slide storehouse 6, unloader and electrical cabinet 3 are installed in right side region on the slide, the side of box 1 is equipped with the opening that corresponds to slide storehouse 6, install door 101 on this opening, open door 101 can get and put slide storehouse 6, and all be connected with handle 16 on slide storehouse 6 the curb plate and the roof that are close to opening one side.
In order to enable the slide boxes 11 of each layer in the slide bin 6 to be flush with the microscope platform 10, lifting of the slide bin 6 needs to be achieved, a lifting platform 14 is arranged at the bottom of the bin body in the embodiment, the lifting platform 14 is also arranged in the right side area of the box body 1, referring to fig. 2 and 3, in order to avoid instable placement of the slide bin 6 on the lifting platform 14, at least one second magnetic steel 1401 and at least two positioning columns 1402 are arranged on the lifting platform 14, the lifting platform 14 in the embodiment is provided with one second magnetic steel 1401 and two positioning columns 1402, the second magnetic steel 1401 is buried in the center of the upper horizontal end face of the lifting platform 14, the two positioning columns 1402 are diagonally arranged, and a second steel sheet 601 which interacts with the second magnetic steel 1401 and a positioning groove 602 corresponding to the positioning column 1402 are arranged at the bottom end of the bin body. In addition, a proximity switch 1403 is further installed on the lifting platform 14 to detect whether the lifting platform 14 has a slide bin 6, the lifting platform 14 is provided with a threaded hole so that the proximity switch 1403 is connected with the threaded hole, the proximity switch 1403 is arranged in a diagonal arrangement staggered with the positioning column 1402, if the bin body is not placed on the lifting platform 14, the proximity switch 1403 is not triggered, and if the bin body is installed, the proximity switch 1403 is triggered, so that the bin body is installed in place.
Further, a notch for exposing the microscope lens 9 is reserved on the box body 1, so that medical staff can observe the microscope lens, an upper lifting cover 2 is arranged on one side of the top of the box body 1, a gas spring is connected between the upper lifting cover 2 and the inner wall of the box body 1 for supporting when the cover is opened, the upper lifting cover 2 is connected with the box body 1 through a lock body, and the upper lifting cover 2 can be opened through unlocking during maintenance.
Further, the left side of the box body 1, which is close to the microscope, is connected with the blade plate 102 through a bolt, when the maintenance is performed, the blade plate 102 can be completely removed to be matched with the assembly and the maintenance, the oil dripping device 8 in the embodiment adopts a low-cost high-capacity universal oil dripping device 8 for a full-automatic microscope, which is disclosed by patent publication number CN218350129U, the oil dripping device 8 is positioned at the left side of the microscope, a small door 1021 corresponding to the oil storage tube 801 is arranged on the blade plate 102, and daily oil filling, the residual quantity of observable mirror oil and the mirror oil filling can be performed after the small door 1021 is opened.
While the invention has been described in connection with specific embodiments, it will be apparent to those skilled in the art that the description is intended to be illustrative and not limiting in scope. Various modifications and alterations of this invention will occur to those skilled in the art in light of the spirit and principles of this invention, and such modifications and alterations are also within the scope of this invention.
Claims (10)
1. The utility model provides a high flux cell chromosome image analysis appearance, includes slide storehouse (6), slide box (11), slide go up unloader, microscope and electrical apparatus cabinet (3), slide storehouse (6) are used for storing slide box (11), slide box (11) are used for installing the slide, slide go up unloader and be used for taking out slide box (11) from slide storehouse (6) place on the microscope or will slide box (11) on the microscope are taken off and are put into in slide storehouse (6), the microscope is used for carrying out the formation of image processing to the slide on slide box (11), electrical apparatus cabinet (3) are used for controlling slide go up unloader and microscope orderly work, its characterized in that:
the slide bin (6) comprises a bin body with front and rear through openings, and grooves (603) for installing a slide box (11) are uniformly formed in the inner walls of the two sides of the bin body;
the slide feeding and discharging device comprises an X-direction linear module (4) and a Z-direction linear module (5), wherein the static part of the Z-direction linear module (5) is connected with the moving part of the X-direction linear module (4), and the moving part of the Z-direction linear module (5) is connected with a push-pull part;
the microscope comprises a microscope platform (10) for placing the slide boxes (11), the push-pull part is used for pushing the slide boxes (11) of each layer in the bin body onto the microscope platform (10) and/or pulling the slide boxes (11) on the microscope platform (10) back into corresponding grooves (603) in the bin body, and one end of the push-pull part, which is propped against the slide boxes (11), is flat.
2. The high-throughput cell chromosome image analyzer of claim 1, wherein the bin body comprises a bottom plate and a top plate, two side plates are connected between the bottom plate and the top plate, wherein at least one side of the side plates, which is positioned on the push-pull part, is provided with positioning pieces, and the positioning pieces are in one-to-one correspondence with the grooves (603).
3. The high-throughput cell chromosome image analyzer according to claim 1 or 2, wherein a pull handle (1101) is provided on a front end side of the slide cassette (11), and a push surface (11011) corresponding to the push-pull portion is provided on a front end of the pull handle (1101).
4. The high-throughput cell chromosome image analyzer according to claim 1, wherein a U-shaped groove (1001) is arranged on the microscope platform (10), a notch (1003) which opens towards two sides is arranged on one side of the U-shaped groove (1001), the slide box (11) is pushed into the U-shaped groove (1001) from the notch (1003) in parallel by the push-pull part, the notch (1003) adopts arc transition, and the groove width of the U-shaped groove (1001) is slightly larger than the width of the slide box (11);
be equipped with the limit structure who is used for fixed slide box (11) on U type groove (1001), limit structure includes first magnet steel (1004) and first steel sheet (1102), the edge in U type groove (1001) is equipped with angle groove (1002) that are used for slide box (11) direction to support, first magnet steel (1004) distribute on the horizontal terminal surface in angle groove (1002), the bottom of slide box (11) is buried first steel sheet (1102) and with first magnet steel (1004) inhale mutually.
5. A high throughput cell chromosome image analyser according to claim 3, wherein the push-pull part comprises an L-shaped rod (7), a longer end of the L-shaped rod (7) abuts against the push surface (11011), the end of the L-shaped rod (7) further comprises a pull block (701), and the pull block (701) is arranged on the side surface of the L-shaped rod (7) and is integrally formed with the L-shaped rod (7).
6. The high-throughput cell chromosome image analyzer according to claim 2, wherein a lifting platform (14) is arranged at the bottom of the bin body, at least one second magnetic steel (1401) and at least two positioning columns (1402) are arranged on the lifting platform (14), a second steel sheet (601) interacted with the second magnetic steel (1401) is arranged at the bottom end of the bin body, and positioning grooves (602) corresponding to the positioning columns (1402) are arranged at the bottom end of the bin body.
7. The high-throughput cell chromosome image analyzer according to claim 2, further comprising a box body (1), wherein the slide bin (6), the slide loading and unloading device, the microscope and the electrical cabinet (3) are all installed in the box body (1), an opening corresponding to the slide bin (6) is arranged on the side surface of the box body (1), and handles (16) are connected to a side plate and a top plate of the slide bin (6) close to one side of the opening.
8. The high-throughput cell chromosome image analyzer of claim 7, wherein the microscope further comprises a microscope lens (9) and an oil dripping device (8), a notch for exposing the microscope lens (9) is reserved on the box body (1), an upper lifting cover (2) is arranged on one side of the top of the box body (1), a gas spring is connected between the upper lifting cover (2) and the inner wall of the box body (1), and the upper lifting cover (2) is connected with the box body (1) through a lock body.
9. The high-throughput cell chromosome image analyzer of claim 8, wherein a blade (102) is detachably connected to one side of the box (1) close to the microscope, and the blade (102) is fixedly connected to the side of the box (1) through bolts.
10. The high-throughput cell chromosome image analyzer as claimed in claim 1, 2 or 6, wherein a limit structure is arranged in the groove (603), the limit structure comprises a third magnetic steel (6031) and a third steel sheet (1103), the third magnetic steel (6031) is embedded in the groove (603), and the third steel sheet (1103) is arranged at two sides of the slide box (11) and matched with the third magnetic steel (6031).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310557380.8A CN116519691A (en) | 2023-05-17 | 2023-05-17 | High-flux cell chromosome image analyzer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310557380.8A CN116519691A (en) | 2023-05-17 | 2023-05-17 | High-flux cell chromosome image analyzer |
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| Publication Number | Publication Date |
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| CN116519691A true CN116519691A (en) | 2023-08-01 |
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| CN202310557380.8A Pending CN116519691A (en) | 2023-05-17 | 2023-05-17 | High-flux cell chromosome image analyzer |
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| WO2014194411A1 (en) * | 2013-06-07 | 2014-12-11 | Clemex Technologies Inc. | Automatic slide loading system and method |
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| CN218752178U (en) * | 2021-05-27 | 2023-03-28 | 深圳市瑞图生物技术有限公司 | Slide storage device and sample analyzer |
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| WO2014194411A1 (en) * | 2013-06-07 | 2014-12-11 | Clemex Technologies Inc. | Automatic slide loading system and method |
| CN111551756A (en) * | 2020-04-01 | 2020-08-18 | 郑州中普医疗器械有限公司 | Full-automatic film-making dyeing scanning system |
| CN112557392A (en) * | 2020-10-16 | 2021-03-26 | 湖南品信生物工程有限公司 | Intelligent chromosome karyotype analyzer |
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