CN116510162A - Accurate urethra dosing rod and preparation method thereof - Google Patents
Accurate urethra dosing rod and preparation method thereof Download PDFInfo
- Publication number
- CN116510162A CN116510162A CN202310422284.2A CN202310422284A CN116510162A CN 116510162 A CN116510162 A CN 116510162A CN 202310422284 A CN202310422284 A CN 202310422284A CN 116510162 A CN116510162 A CN 116510162A
- Authority
- CN
- China
- Prior art keywords
- fiber cotton
- rod
- urethral
- stick
- drug delivery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 210000003708 urethra Anatomy 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title abstract description 10
- 229920000742 Cotton Polymers 0.000 claims abstract description 60
- 239000000835 fiber Substances 0.000 claims abstract description 55
- 239000000017 hydrogel Substances 0.000 claims abstract description 37
- 239000003814 drug Substances 0.000 claims abstract description 34
- 238000012377 drug delivery Methods 0.000 claims abstract description 33
- 238000004132 cross linking Methods 0.000 claims abstract description 24
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000011248 coating agent Substances 0.000 claims abstract description 23
- 238000000576 coating method Methods 0.000 claims abstract description 23
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 23
- 239000000661 sodium alginate Substances 0.000 claims abstract description 23
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 23
- 229940079593 drug Drugs 0.000 claims abstract description 21
- 238000005461 lubrication Methods 0.000 claims abstract description 16
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 15
- 201000010099 disease Diseases 0.000 claims abstract description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 15
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 15
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 15
- 229960002901 sodium glycerophosphate Drugs 0.000 claims abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 11
- 238000001356 surgical procedure Methods 0.000 claims abstract description 9
- 230000002485 urinary effect Effects 0.000 claims abstract description 9
- 238000006243 chemical reaction Methods 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 18
- 239000002131 composite material Substances 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 7
- 206010065584 Urethral stenosis Diseases 0.000 claims description 6
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical compound [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims description 6
- 159000000007 calcium salts Chemical class 0.000 claims description 6
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 6
- 238000009738 saturating Methods 0.000 claims description 6
- 201000001988 urethral stricture Diseases 0.000 claims description 6
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims description 4
- 229960004703 clobetasol propionate Drugs 0.000 claims description 4
- 239000011259 mixed solution Substances 0.000 claims description 4
- 229960001967 tacrolimus Drugs 0.000 claims description 4
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
- 239000001110 calcium chloride Substances 0.000 claims description 3
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 3
- 239000000378 calcium silicate Substances 0.000 claims description 3
- 229910052918 calcium silicate Inorganic materials 0.000 claims description 3
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 claims description 3
- -1 compound clobetasol propionate Chemical class 0.000 claims description 3
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 3
- 229960003957 dexamethasone Drugs 0.000 claims description 3
- 239000012266 salt solution Substances 0.000 claims description 3
- 239000011159 matrix material Substances 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 6
- 239000011148 porous material Substances 0.000 abstract description 5
- 238000004873 anchoring Methods 0.000 abstract description 4
- 239000000499 gel Substances 0.000 abstract description 4
- 238000003780 insertion Methods 0.000 abstract description 2
- 230000037431 insertion Effects 0.000 abstract description 2
- 230000009286 beneficial effect Effects 0.000 abstract 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 2
- 229960000520 diphenhydramine Drugs 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- CBGUOGMQLZIXBE-XGQKBEPLSA-N clobetasol propionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CBGUOGMQLZIXBE-XGQKBEPLSA-N 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- AVPCPPOOQICIRJ-UHFFFAOYSA-L sodium glycerol 2-phosphate Chemical compound [Na+].[Na+].OCC(CO)OP([O-])([O-])=O AVPCPPOOQICIRJ-UHFFFAOYSA-L 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1078—Urinary tract
- A61M2210/1089—Urethra
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a urethra accurate drug delivery rod and a preparation method thereof. The drug delivery rod comprises a matrix rod, wherein the matrix rod comprises a handle and a fiber cotton rod body with pores on the surface, and the fiber cotton rod body is connected with the distal end of the handle; the distal end of the fiber cotton stick body is bent away from the axis to one side; the drug delivery stick also comprises a super-lubrication hydrogel coating coated on the fiber cotton stick body; the coating is prepared by the cross-linking reaction of raw materials including sodium alginate, hyaluronic acid, beta-sodium glycerophosphate and medicines for treating related diseases of urinary surgery in a cross-linking curing bath. The preparation method of the drug delivery rod is simple, the cost is low, the coating has ultra-high hydrophilicity and ultra-lubricity, and the uncomfortable feeling of a patient in the insertion process can be greatly reduced; the coating and the matrix rod have good anchoring effect, so that the medicine-carrying gel layer is prevented from falling off or sliding out in the inserting process; in addition, both the matrix rod and the coating can carry medicine and can stimulate the release of the medicine under the temperature and the pressure, thereby being beneficial to the treatment of diseases.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a urethra accurate drug delivery rod and a preparation method thereof.
Background
Targeted or precise administration is the most effective route to improve drug utilization efficiency and reduce physical damage. At present, the administration through the urethra is a common administration mode in the treatment process of related diseases of urinary surgery, and particularly, the administration mode has a plurality of applications in the treatment of urethral stricture and postoperative rehabilitation of urethral stricture. At present, the common administration mode for treating the urethral stricture is to coat the drug ointment on the catheter, and then insert the catheter with the drug into the corresponding position through the urethra, thereby achieving the purpose of administration. However, the method has low administration efficiency, low drug utilization rate, unsatisfactory treatment effect, inconvenient use, easy secondary infection caused by improper operation, and the like. There is therefore a need for a more accurate way of urinary tract administration.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention provides a urethra accurate drug administration rod and a preparation method thereof.
In order to achieve the above purpose, the invention adopts the following technical scheme:
a first aspect of the present invention is to provide a urethral precision drug delivery stick comprising a base stick comprising a handle and a cellucotton body having a surface with a void connected to a distal end of the handle; the distal end of the fiber cotton stick body is bent away from the axial line to one side; the dosing rod also comprises a super-lubrication hydrogel coating coated on the fiber cotton rod body;
the super-lubricating hydrogel coating is prepared by the cross-linking reaction of raw materials comprising sodium alginate, hyaluronic acid, beta-sodium glycerophosphate and medicines for treating related diseases of urinary surgery in a cross-linking curing bath.
Further, the mass ratio of the sodium alginate, the hyaluronic acid, the beta-sodium glycerophosphate and the medicine for treating the related diseases of the urinary surgery in the super-lubricated hydrogel coating is 1-10: 0.1 to 5:1 to 60: 0.001-10.
Further, the medicament for treating the urologic related diseases is a medicament for treating urethral stricture, and preferably comprises one or more than one of diphenhydramine, tacrolimus, compound clobetasol propionate and dexamethasone.
Further, the handle and the fiber cotton stick body are integrally formed.
Further, the fiber cotton stick body is fixedly connected with the handle.
Further, the handle is pear-shaped or dumbbell-shaped.
Further, the angle between the arc formed by bending the distal end of the fiber cotton stick body and the axis is 10-30 degrees.
Further, the crosslinking curing bath is a soluble calcium salt solution and comprises one or more of calcium chloride, calcium nitrate, calcium sulfate and calcium silicate; the concentration of the soluble calcium salt is 0.1-10%.
The second aspect of the present invention provides a method for preparing the urethral precision drug delivery stick, comprising the steps of:
immersing the distal end of the fiber cotton stick body into sodium alginate solution, and fully absorbing and saturating;
immersing the distal end of the fiber cotton stick body into a composite solution of sodium alginate, hyaluronic acid, beta-sodium glycerophosphate and a medicament for treating related diseases of urinary surgery to enable the composite solution to be adhered to the fiber cotton stick body;
and thirdly, immersing the distal end of the fiber cotton stick body into crosslinking curing liquid, and crosslinking for 1-60 min to obtain the urethra precise drug delivery stick loaded with the super-lubrication drug-carrying hydrogel.
Further, the concentration of the sodium alginate solution in the first step is 1-10%.
Compared with the prior art, the invention has the following technical effects:
the preparation method of the drug delivery rod has simple process and low cost, and the synthesized hydrogel coating has ultrahigh hydrophilicity and super lubricity, so that the discomfort of a patient in the process of insertion can be greatly reduced; secondly, creatively selecting a fiber cotton stick as a matrix stick, wherein the fiber cotton stick has a loose porous structure and certain hardness and toughness, is deformable, can adsorb moisture and medicines, and because of the porous structure on the surface of the cotton stick, hydrogel can permeate into pores on the surface of the cotton stick, and an antenna is formed after solidification, so that a good anchoring effect is realized between a coating and the matrix stick, and the falling or sliding-out of a medicine-carrying gel layer in the inserting process is avoided; in addition, both the matrix rod and the hydrogel coating may be drug loaded and may stimulate drug release at temperature and pressure.
Drawings
FIG. 1 is a schematic view of a urethral precision drug delivery stick loaded with a super-lubricious carrier hydrogel in accordance with one embodiment of the present invention; wherein, the 1-substrate rod and the 2-super-lubricated hydrogel coating;
fig. 2 shows an enlarged cross-sectional view of the urethra precision drug delivery rod a of fig. 1;
fig. 3 shows a graph of contact angle of a urethral precision drug delivery stick loaded with a superlubrication carrier hydrogel prepared in example 1;
FIG. 4 shows the friction coefficient curve of the urethral precision drug delivery stick loaded with the superlubrication carrier hydrogel prepared in example 1;
fig. 5 shows the drug release profile of the urethral precision drug delivery stick loaded with the superlubrication loaded hydrogel prepared in example 1.
Detailed Description
The invention provides a urethra accurate drug delivery rod, which comprises a basal body rod 1, wherein the basal body rod 1 comprises a handle and a fiber cotton rod body, wherein the surface of the fiber cotton rod body is connected with the distal end of the handle, and the surface of the fiber cotton rod body is provided with pores; the distal end of the fiber cotton stick body is bent away from the axial line to one side; the dosing rod also comprises a super-lubricated hydrogel coating 2 (shown in figure 1) coated on the fiber cotton rod body;
wherein the super-lubricating hydrogel coating 2 is obtained by the cross-linking reaction of raw materials comprising sodium alginate, hyaluronic acid, beta-sodium glycerophosphate and medicines for treating related diseases of urinary surgery in a cross-linking curing bath. Because the porosity of the fiber cotton swab body (figure 2) can enable the hydrogel to enter the pores, an anchoring effect is formed between the super-lubrication hydrogel coating and the swab body, and the hydrogel coating can be firmly attached to the surface of the porous cotton swab.
As used herein, "distal" and "proximal" are proximal to an operator (e.g., a physician) and correspondingly distal to the operator in actual use.
In a preferred embodiment of the present invention, the mass ratio of the sodium alginate, the hyaluronic acid, the sodium beta-glycerophosphate and the drug for treating the urology related diseases included in the super-lubricated hydrogel coating 2 is 1-10: 0.1 to 5:1 to 60: 0.001-10.
In a preferred embodiment of the present invention, the medicament for treating a urologic related disease is a medicament for treating urethral stricture, and preferably includes one or more of diphenhydramine, tacrolimus, clobetasol propionate, dexamethasone, and the like.
In a preferred embodiment of the present invention, the handle and the fiber swab body are integrally formed. As shown in FIG. 1, the handle is pear-shaped, and is convenient to hold. In a preferred embodiment of the invention, the handle may also be dumbbell-shaped for ease of grasping.
In a preferred embodiment of the present invention, the cellucotton body is fixedly connected to the handle. The handle may be of plastics material. In a preferred embodiment of the invention, the connection is such that the distal end of the handle engages the proximal end of the body.
In a preferred embodiment of the present invention, the angle α between the curved line formed by the distal end of the fiber cotton swab body and the axis is 10 to 30 °.
In a preferred embodiment of the present invention, the crosslinking curing bath is a soluble calcium salt solution including one or more of calcium chloride, calcium nitrate, calcium sulfate, and calcium silicate; the concentration of the soluble calcium salt is 0.1-10%.
The second aspect of the present invention provides a method for preparing the urethral precision drug delivery stick, comprising the steps of:
immersing the distal end of the fiber cotton stick body into sodium alginate solution, and fully absorbing and saturating;
immersing the distal end of the fiber cotton stick body into a composite solution of sodium alginate, hyaluronic acid, beta-sodium glycerophosphate and a medicament for treating related diseases of urinary surgery to enable the composite solution to be adhered to the fiber cotton stick body; wherein the concentration of the sodium alginate is 1-10wt%, the concentration of the hyaluronic acid is 0.1-5wt%, the concentration of the beta-sodium glycerophosphate is 1-60wt%, and the concentration of the medicament is 0.001-10wt%.
Immersing the distal end of the fiber cotton stick body into a crosslinking curing liquid, wherein the concentration of the crosslinking curing liquid is 0.1-10wt%, and crosslinking for 1-60 min to obtain the urethra precise drug delivery stick loaded with the super-lubrication drug-carrying hydrogel.
The drug delivery rod provided by the invention adopts nontoxic and biodegradable absorbed sodium alginate as a gel skeleton, hyaluronic acid as a super-lubrication buffer, beta-sodium glycerophosphate as a drug carrier and a temperature-sensitive control agent, and the drug delivery rod is crosslinked in a calcium ion solution to form a super-lubrication hydrogel coating; the hydrogel can be infiltrated into the porous fiber cotton stick body to form an antenna anchoring effect with the fiber cotton stick body, so that the hydrogel coating can be firmly attached to the surface of the porous cotton stick; the fiber cotton stick body has a certain hardness and toughness, the changeable porous fiber cotton stick body with a certain radian of the far end is convenient for entering the urethra and can alleviate the discomfort of patients.
The present invention will be described in detail and specifically by way of the following specific examples and drawings to provide a better understanding of the present invention, but the following examples do not limit the scope of the present invention.
Example 1
The embodiment provides a urethra accurate drug delivery rod loaded with super-lubrication drug-loaded hydrogel, and the preparation method comprises the following steps:
immersing the distal end of the fiber cotton stick body into a sodium alginate solution with the weight percent of 2%, and fully absorbing and saturating;
immersing the distal end of the fiber cotton stick body into a composite solution of 2wt% of sodium alginate, 1wt% of hyaluronic acid, 10wt% of beta-sodium glycerophosphate and 0.5wt% of bifeitin to enable the mixed solution with certain viscosity to adhere to the fiber cotton stick body;
and thirdly, immersing the distal end of the fiber cotton stick body into 3wt% of crosslinking curing liquid, and crosslinking for 30min to obtain the urethra precise drug delivery stick loaded with the super-lubrication drug-carrying hydrogel, wherein the structure of the urethra precise drug delivery stick is shown in figure 1.
Fig. 2 shows an enlarged cross-sectional view of the precise urethral delivery stick a of fig. 1, i.e., the fiber of the fiber cotton stick is wound around a porous structure so that the surface of the fiber cotton stick is porous, hydrogel can penetrate into pores on the surface of the cotton stick, and the hydrogel can form tentacles after being solidified, so that the gel layer on the surface of the cotton stick can be riveted and fixed.
Fig. 3 shows a photograph of the contact angle test of the urethral precision dosing rod, illustrating that the synthesized hydrogel coating has ultra-high hydrophilicity.
Fig. 4 shows the friction coefficient curve of the urethral precision drug delivery stick, and it can be seen that the friction coefficient of the surface of the hydrogel layer is as low as 0.098, indicating that the drug delivery stick has good lubrication performance.
Fig. 5 shows the drug release profile of the urethral precision drug delivery stick, and it can be seen that the drug content in the solution gradually increases with time, and the drug release reaches the maximum value when 60min is reached, that is, the drug delivery stick can rapidly release the drug within 60 min.
Example 2
The embodiment provides a urethra accurate drug delivery rod loaded with super-lubrication drug-loaded hydrogel, and the preparation method comprises the following steps:
immersing the distal end of the fiber cotton stick body into 3wt% sodium alginate solution, and fully absorbing and saturating;
immersing the distal end of the fiber cotton stick body into a composite solution of 3wt% of sodium alginate, 2wt% of hyaluronic acid, 30wt% of beta-sodium glycerophosphate and 1wt% of tacrolimus to enable the mixed solution with certain viscosity to be adhered on the fiber cotton stick body;
and thirdly, immersing the distal end of the fiber cotton stick body into 5wt% of crosslinking curing liquid, and crosslinking for 10min to obtain the urethra precise drug delivery stick loaded with the super-lubrication drug-carrying hydrogel.
Example 3
The embodiment provides a urethra accurate drug delivery rod loaded with super-lubrication drug-loaded hydrogel, and the preparation method comprises the following steps:
immersing the distal end of the fiber cotton stick body into a sodium alginate solution with the concentration of 6wt%, and fully absorbing and saturating;
immersing the distal end of the fiber cotton stick body into a composite solution of 6wt% of sodium alginate, 3wt% of hyaluronic acid, 10wt% of beta-sodium glycerophosphate and 2wt% of compound clobetasol propionate to enable the mixed solution with certain viscosity to be adhered on the fiber cotton stick body;
and thirdly, immersing the distal end of the fiber cotton stick body into a crosslinking curing liquid with the weight percent of 1 percent, and crosslinking for 60 minutes to obtain the urethra precise drug delivery stick loaded with the super-lubrication drug-carrying hydrogel.
The above description of the specific embodiments of the present invention has been given by way of example only, and the present invention is not limited to the above described specific embodiments. It will be apparent to those skilled in the art that any equivalent modifications and substitutions of the present invention are intended to be within the scope of the present invention. Accordingly, equivalent changes and modifications are intended to be included within the scope of the present invention without departing from the spirit and scope thereof.
Claims (10)
1. The urethral accurate drug delivery stick is characterized by comprising a basal body stick, wherein the basal body stick comprises a handle and a fiber cotton stick body, and the surface of the fiber cotton stick body is connected with the distal end of the handle; the far end of the fiber cotton stick body is bent to one side far away from the axis; the dosing rod also comprises a super-lubrication hydrogel coating coated on the fiber cotton rod body;
the super-lubricating hydrogel coating is prepared by the cross-linking reaction of raw materials comprising sodium alginate, hyaluronic acid, beta-sodium glycerophosphate and medicines for treating related diseases of urinary surgery in a cross-linking curing bath.
2. The precise urethral dosing rod according to claim 1, wherein the mass ratio of sodium alginate, hyaluronic acid, beta-sodium glycerophosphate and the drug for treating urologic related diseases contained in the super-lubricated hydrogel coating is 1-10: 0.1 to 5:1 to 60: 0.001-10.
3. The precise urethral dosing rod according to claim 1, wherein the medicine for treating urologic related diseases is a medicine for treating urethral stricture, and preferably comprises one or more of bifeitine, tacrolimus, compound clobetasol propionate and dexamethasone.
4. The urethral precision dosing rod of claim 1 wherein the handle and fibrous cotton swab body are integrally formed.
5. The precise urethral dosing rod of claim 1, wherein the fiber cotton stick body is fixedly connected to the handle.
6. The urethral precision dosing rod of claim 1 wherein the handle is pear-shaped or dumbbell-shaped.
7. The precise urethral delivery stick of claim 1, wherein the distal end of the body is curved at an angle of between 10 ° and 30 ° to the axis.
8. The urethral precision dosing rod of claim 1 wherein the cross-linking curing bath is a soluble calcium salt solution comprising one or more of calcium chloride, calcium nitrate, calcium sulfate, calcium silicate; the concentration of the soluble calcium salt is 0.1-10%.
9. A method of preparing a urethral precision drug delivery stick according to any one of claims 1-8, comprising the steps of:
immersing the distal end of the fiber cotton stick body into sodium alginate solution, and fully absorbing and saturating;
immersing the distal end of the fiber cotton stick body into a composite solution of sodium alginate, hyaluronic acid, beta-sodium glycerophosphate and a medicament for treating related diseases of urinary surgery to enable the mixed solution to adhere to the fiber cotton stick body;
and thirdly, immersing the distal end of the fiber cotton stick body into crosslinking curing liquid, and crosslinking for 1-60 min to obtain the urethra precise drug delivery stick loaded with the super-lubrication drug-carrying hydrogel.
10. The method according to claim 9, wherein the concentration of the sodium alginate solution in the first step is 1 to 10%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310422284.2A CN116510162A (en) | 2023-04-19 | 2023-04-19 | Accurate urethra dosing rod and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310422284.2A CN116510162A (en) | 2023-04-19 | 2023-04-19 | Accurate urethra dosing rod and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116510162A true CN116510162A (en) | 2023-08-01 |
Family
ID=87395239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310422284.2A Withdrawn CN116510162A (en) | 2023-04-19 | 2023-04-19 | Accurate urethra dosing rod and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116510162A (en) |
-
2023
- 2023-04-19 CN CN202310422284.2A patent/CN116510162A/en not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101411898B (en) | Organic/inorganic composite antibiotic catheters and preparation method thereof | |
| US20080254094A1 (en) | Biomaterials Carrying Cyclodextrines Having Improved Absorption Properties and Used for the Progressive and Delayed Release of Therapeutic Molecules | |
| WO2012109187A1 (en) | Methods and devices for preventing catheter related urinary tract infections | |
| WO2010151682A2 (en) | Silicone catheter containing chlorhexidine gluconate | |
| JP2006511226A5 (en) | ||
| CN104812339A (en) | Sheath for securing urinary catheter | |
| CN115124738B (en) | Double-layer bionic drug-loaded hydrogel and preparation and application thereof | |
| EP1601324A2 (en) | Hemostatic compositions and methods | |
| CN116510162A (en) | Accurate urethra dosing rod and preparation method thereof | |
| CN112870451B (en) | Nerve sheath tube and preparation method and application thereof | |
| CN109758620B (en) | Long-acting antibacterial degradable ureteral stent and preparation method thereof | |
| CN110404120A (en) | A kind of preparation method of front end softening catheter | |
| CN1596991B (en) | Sterilization bamboo fiber gauze and its preparation method and application | |
| CN112915265A (en) | Hydrophilic, antibacterial and degradable ureteral stent and preparation method thereof | |
| CN114163925A (en) | Method for modifying hydrogel lubricating coating on surface of universal equipment and universal equipment modified with hydrogel lubricating coating | |
| CN106422027A (en) | Coating method applied to silica gel catheter | |
| JP3599784B2 (en) | Medical device with lubricious surface when wet | |
| JP2002501406A (en) | Gel for wound dressing | |
| JP2001000531A (en) | Medical implement having lubricity | |
| KR20180101767A (en) | The composition for catheter, the central venous catheter and the intravascular tube catheter prepared by using the same | |
| CN220714471U (en) | Medicine-carrying catheter | |
| CN117018299A (en) | Medical catheter super-lubrication coating and preparation method thereof | |
| JP2004215709A (en) | Medical hydrogel comprising different polymeric compounds | |
| CN117205357A (en) | Medical antibacterial gauze and preparation method thereof | |
| EP3247282B1 (en) | Prostate biopsy needle |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20230801 |