CN116508756A - Sustained-release antibacterial mildew-proof composition, and preparation method and application thereof - Google Patents
Sustained-release antibacterial mildew-proof composition, and preparation method and application thereof Download PDFInfo
- Publication number
- CN116508756A CN116508756A CN202310257982.1A CN202310257982A CN116508756A CN 116508756 A CN116508756 A CN 116508756A CN 202310257982 A CN202310257982 A CN 202310257982A CN 116508756 A CN116508756 A CN 116508756A
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- CN
- China
- Prior art keywords
- mildew
- slow
- proof
- release
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 109
- 239000000203 mixture Substances 0.000 title claims abstract description 99
- 238000013268 sustained release Methods 0.000 title claims description 9
- 239000012730 sustained-release form Substances 0.000 title claims description 9
- 238000002360 preparation method Methods 0.000 title abstract description 12
- HYBBIBNJHNGZAN-UHFFFAOYSA-N furfural Chemical compound O=CC1=CC=CO1 HYBBIBNJHNGZAN-UHFFFAOYSA-N 0.000 claims description 67
- 150000007524 organic acids Chemical class 0.000 claims description 48
- 235000013305 food Nutrition 0.000 claims description 31
- 230000003385 bacteriostatic effect Effects 0.000 claims description 27
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 25
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 18
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims description 13
- KEFJLCGVTHRGAH-UHFFFAOYSA-N 2-acetyl-5-methylfuran Chemical compound CC(=O)C1=CC=C(C)O1 KEFJLCGVTHRGAH-UHFFFAOYSA-N 0.000 claims description 12
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 12
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 12
- XPFVYQJUAUNWIW-UHFFFAOYSA-N furfuryl alcohol Chemical compound OCC1=CC=CO1 XPFVYQJUAUNWIW-UHFFFAOYSA-N 0.000 claims description 12
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 claims description 12
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- 239000000126 substance Substances 0.000 claims description 10
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- PQFIBPDAGFGLBY-UHFFFAOYSA-N 3-(Acetylthio)-2-methylfuran Chemical compound CC(=O)SC=1C=COC=1C PQFIBPDAGFGLBY-UHFFFAOYSA-N 0.000 claims description 4
- INAXVXBDKKUCGI-UHFFFAOYSA-N 4-hydroxy-2,5-dimethylfuran-3-one Chemical compound CC1OC(C)=C(O)C1=O INAXVXBDKKUCGI-UHFFFAOYSA-N 0.000 claims description 4
- FCWYQRVIQDNGBI-UHFFFAOYSA-N Dihydro-2-methyl-3(2H)-furanone Chemical compound CC1OCCC1=O FCWYQRVIQDNGBI-UHFFFAOYSA-N 0.000 claims description 4
- GMEONFUTDYJSNV-UHFFFAOYSA-N Ethyl levulinate Chemical compound CCOC(=O)CCC(C)=O GMEONFUTDYJSNV-UHFFFAOYSA-N 0.000 claims description 4
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- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 3
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- AWQSAIIDOMEEOD-UHFFFAOYSA-N 5,5-Dimethyl-4-(3-oxobutyl)dihydro-2(3H)-furanone Chemical compound CC(=O)CCC1CC(=O)OC1(C)C AWQSAIIDOMEEOD-UHFFFAOYSA-N 0.000 claims description 2
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- IAJNLJPHAMEYLW-UHFFFAOYSA-N benzenethiol 1,3-xylene Chemical compound C1(=CC=CC=C1)S.CC1=CC=CC(=C1)C IAJNLJPHAMEYLW-UHFFFAOYSA-N 0.000 claims description 2
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- HDJLSECJEQSPKW-UHFFFAOYSA-N Methyl 2-Furancarboxylate Chemical compound COC(=O)C1=CC=CO1 HDJLSECJEQSPKW-UHFFFAOYSA-N 0.000 description 2
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
- A01N43/08—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/18—Vapour or smoke emitting compositions with delayed or sustained release
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P3/00—Fungicides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3481—Organic compounds containing oxygen
- A23L3/3508—Organic compounds containing oxygen containing carboxyl groups
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3544—Organic compounds containing hetero rings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention belongs to the technical field of antibacterial and mildew-proof materials, and provides a slow-release antibacterial and mildew-proof composition, and a preparation method and application thereof.
Description
Technical Field
The invention relates to the technical field of antibacterial and mildew-proof materials, in particular to a slow-release antibacterial and mildew-proof composition, a preparation method and application thereof.
Background
The food contains abundant nutritional ingredients such as protein, carbohydrate, fat, etc., and is easy to grow microorganisms in long-term storage process to cause spoilage. The mildew is used as one of microorganism members, has stronger capability of decomposing polysaccharide and starch, can cause mildew and deterioration of grains, baked foods, fruits and the like in a humid environment, further causes huge resource waste and economic loss, and even produces toxic secondary metabolites (mycotoxins) to influence the physical health of people.
In order to inhibit the mildew of food, prolong the shelf life of the food and ensure the safety of the food, the prior art generally stores the food together with the food by adding a mildew inhibitor, an external control mildew-proof bag and the like, thereby inhibiting food microorganisms. The external control type mildew-proof bag is mainly divided into a cleaning type mildew-proof bag and a release type mildew-proof bag, wherein the cleaning type mildew-proof bag adopts deoxidizing agents, drying agents and the like to remove free oxygen and water vapor in the internal environment of the food package, so that the food is in a low-oxygen and dry environment, and the aim of inhibiting the growth of microorganisms is fulfilled. Therefore, when the scavenging type mildew-proof bag is adopted, packaging materials with good air tightness and poor air permeability are required to be selected for sealing the food. The cleaning type mildew-proof bag has higher requirement on packaging materials and has larger use limit.
The release type mildew-proof bag is prepared by putting a semi-volatile or volatile antibacterial agent into a food packaging bag, and penetrating into food to prolong the shelf life of the food. At present, the release type mildew-proof bag is generally provided with an alcohol sheet, an active film and the like, wherein the alcohol sheet has a good mildew-proof effect, but can influence the flavor of food, the alcohol is extremely volatile, the alcohol sheet needs to be used immediately within 30 minutes after being opened, otherwise, the antibacterial effect of the alcohol sheet can be influenced, and therefore, the use of the alcohol sheet has a stricter time limit. The active membrane is mainly compounded by adopting a high molecular polymer and an active substance, and the slow release of the active substance is realized by utilizing a multi-layer composite membrane, but the active membrane has the advantages of complex structure, complex preparation process and high product cost. Therefore, development of a bacteriostatic and mildew-proof agent with good bacteriostatic and mildew-proof effects, long action time, simple preparation process and low cost is needed.
Disclosure of Invention
The present invention aims to solve at least one of the technical problems in the prior art described above. Therefore, the invention provides the slow-release antibacterial and mildew-proof composition, and the preparation method and application thereof.
The first aspect of the invention provides a slow-release antibacterial and mildew-proof composition.
Specifically, a slow-release antibacterial mildew-proof composition comprises antibacterial components and carrier substances, wherein the antibacterial components comprise volatile organic matters A and organic acids;
the volatile organic compound A is furfural and/or furfural derivatives;
the organic acid is one or more of acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, heptanoic acid, caprylic acid and nonanoic acid.
According to the invention, the volatile organic matter A and the organic acid which have volatility and antibacterial performance are compounded to be used as antibacterial components, wherein the volatile organic matter A is furfural and/or furfural derivatives, the organic acid is one or more of acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, enanthic acid, caprylic acid and pelargonic acid (namely one or more of C2-C9 organic acids), the volatile organic matter A and the organic acid have volatility, the furfural or the derivatives thereof can interfere the cell structure of microorganisms to influence the permeability of the cell structure, the organic acid can reduce the pH value of the microbial environment, and meanwhile, the dissociation of the organic acid can interfere the metabolism of microorganisms, and as the volatile organic matter A and the organic acid have different volatilization rates, the synergistic antibacterial mildew prevention effect can be realized by continuously volatilizing at the same time, the defect that the volatilization rate of a single component is too slow (the antibacterial mildew prevention effect is too weak due to the too fast volatilization rate) or the slow release mildew prevention cost of the slow release mildew prevention composition is too short to increase is overcome, and the slow release mildew prevention carrier can be used for making the slow release mildew prevention composition to absorb the slow release mildew prevention composition for foods.
Preferably, the molar ratio of the volatile organic compound A to the organic acid is 1:0.1-10.
Further preferably, the molar ratio of the volatile organic compound a to the organic acid is 1:0.1-5.
More preferably, the molar ratio of the volatile organic compound a to the organic acid is 1:1-3.
Preferably, the slow-release antibacterial mildew-proof composition comprises the following components in percentage by mass:
0.05-10% of volatile organic matter A, 0.05-10% of organic acid and 80-99% of carrier material.
Preferably, the saturated vapor pressure of the furfural at 25 ℃ is 0.02-15.00mmHg.
Further preferably, the saturated vapor pressure of the furfural at 25 ℃ is 0.5-5.00mmHg.
Preferably, the saturated vapor pressure of the furfural derivative at 25 ℃ is 0.02-15.00mmHg.
Further preferably, the saturated vapor pressure of the furfural derivative at 25 ℃ is 0.5-2.00mmHg.
Preferably, the saturated vapor pressure of the organic acid at 25 ℃ is 0.001-20.00mmHg.
Further preferably, the saturated vapor pressure of the organic acid at 25 ℃ is 0.009-16.00mmHg.
Preferably, the feedstock for preparing the furfural comprises a lignocellulosic biomass extract.
Further preferably, the raw materials for preparing the furfural comprise one or more of corncob extract, oat hull extract, cotton hull extract, bagasse extract, birch extract, chestnut extract, oak extract, olive extract, rice hull extract and sunflower hull extract.
The furfural derivative is a product obtained by biocatalysis of furfural.
Preferably, the furfural derivative is one or more of N-furfurylpyrrole, 4-hydroxy-2, 5-dimethyl-3 (2H) -furanone, methylfurfuryl disulfide, 4- (2-furyl) -3-butene-2-one, difurfuryl ether, 2, 6-dimethylbenzylthiophenol, 3-acetylthio-2-methylfuran, gamma-valerolactone, ethyl levulinate, 2-acetyl-5-methylfuran, tetrahydrofurfuryl alcohol, furfuryl isopropyl sulfide, 2-thiofuroic acid methyl ester, 2-acetylfuran, furfuroic acid methyl ester, furfuryl alcohol, furfurfuryl methyl sulfide, furfuryl mercaptan (also known as caffeic aldehyde), 2-methyltetrahydrofuran-3-one and furfuryl methyl ether.
Preferably, the carrier material is one or more of zeolite, diatomite, quartz sand and natural high molecular polysaccharide.
Preferably, the natural high molecular polysaccharide substance is one or more of cellulose, starch, cyclodextrin and pectin.
Preferably, the slow-release antibacterial mildew-proof composition is one of granules, pills, active films and tablets.
Preferably, the pore size of the support material is from 0.8 to 100nm.
Preferably, the slow-release antibacterial mildew-proof composition further comprises water and an auxiliary agent.
Preferably, the auxiliary agent comprises an emulsifier and/or a binder.
Preferably, the emulsifier is a modified starch.
Preferably, the binder is sodium carboxymethyl cellulose.
The second aspect of the invention provides a preparation method of the slow-release antibacterial and mildew-proof composition.
A preparation method of a slow-release antibacterial mildew-proof composition comprises the following steps:
and mixing the components, and forming to obtain the slow-release antibacterial mildew-proof composition.
Preferably, the preparation method of the slow-release antibacterial mildew-proof composition comprises the following steps:
the preparation method comprises the steps of mixing volatile organic matter A, organic acid, water and an emulsifying agent, emulsifying, adding a carrier material and a binder, mixing, and molding to obtain the slow-release antibacterial mildew-proof composition.
Preferably, the molding is one of extrusion granulation, film compression molding and tabletting molding.
The third aspect of the invention provides the use of a slow-release antibacterial and mildew-proof composition.
An application of a slow-release antibacterial and mildew-proof composition in the field of food antibacterial and mildew-proof.
A bacteriostatic and mildew-resistant method for extending the shelf life of a food product, comprising the steps of:
the slow-release antibacterial mildew-proof composition is placed in a food packaging bag.
Preferably, the mass of the slow-release antibacterial mildew-proof composition is 0.1-10% of the mass of food in the food packaging bag.
Compared with the prior art, the invention has the following beneficial effects:
(1) The slow-release antibacterial mildew-proof composition comprises antibacterial components and carrier substances, volatile organic matters A and organic acids are adopted as the antibacterial components, the volatile organic matters A are furfural and/or furfural derivatives, the organic acids are one or more of acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, enanthic acid, caprylic acid and pelargonic acid, the adopted raw materials can be extracted from natural plants, the source is safe, the antibacterial mildew-proof effect of the slow-release antibacterial mildew-proof composition is good, the action time is long, and the volatile organic matters A and the organic acids can be continuously released within 30 days;
(2) The invention provides a bacteriostatic and mildew-proof method for prolonging the shelf life of food, which is characterized in that a slow-release bacteriostatic and mildew-proof composition is directly placed in a food packaging bag, a mildew-proof and bacteriostatic atmosphere is formed in the food packaging bag by utilizing the volatility of bacteriostatic components, and the slow-release and long-acting release of volatile active substances (volatile organic substances A and organic acids) can be realized, so that the effects of preventing the food from mildew and inhibiting bacteria are achieved, the slow-release bacteriostatic and mildew-proof composition can continuously release the volatile organic substances A and the organic acids for 15 days or even 30 days, the shelf life and the shelf life of the food can be prolonged, the addition amount of the bacteriostatic and mildew-proof components in the food can be reduced, and the cost can be reduced.
Detailed Description
In order to make the technical solutions of the present invention more apparent to those skilled in the art, the following examples will be presented. It should be noted that the following examples do not limit the scope of the invention.
The starting materials, reagents or apparatus used in the following examples are all available from conventional commercial sources or may be obtained by methods known in the art unless otherwise specified.
Saturated vapor pressure: in a closed condition, the pressure of the vapor in equilibrium with the solid or liquid is at a certain temperature. The greater the saturated vapor pressure, the greater the volatility. The saturated vapor pressure may represent how readily the substance volatilizes.
The saturated vapor pressures of the furfural and the derivatives thereof and the C2-C9 organic acid adopted by the invention are shown in the table 1.
TABLE 1 saturated vapor pressure of Furfural and its derivatives, C2-C9 organic acids
Examples 1 to 9
The slow-release antibacterial and mildew-proof composition of examples 1-9 comprises volatile organic compound A, organic acid and carrier material. The composition is shown in Table 2.
Table 2 Components of examples and comparative examples and amounts of the components used in example 10
Example 10 is 168 slow-release antibacterial and mildew-proof compositions, each comprising volatile organic compound A, organic acid and carrier material, the carrier material being mesoporous zeolite. The slow-release antibacterial and mildew-proof composition comprises, by mass, 1% of the total mass of volatile organic matter A and organic acid (the molar ratio of the volatile organic matter A to the organic acid is 1:1), 72% of a carrier substance, 19% of water, 4% of modified starch and 4% of sodium carboxymethyl cellulose. The specific combinations are shown in Table 4. The volatile organic matter A is selected from one of N-furfuryl pyrrole, 4-hydroxy-2, 5-dimethyl-3 (2H) -furanone, methyl furfuryl disulfide, 4- (2-furyl) -3-butene-2-one, difurfuryl ether, 2, 6-dimethyl thiophenol, 3-acetylthio-2-methyl furan, gamma-valerolactone, ethyl levulinate, 2-acetyl-5-methyl furan, tetrahydrofurfuryl alcohol, furfuryl isopropyl sulfide, 2-thiofuroic acid methyl ester, 2-acetyl furan, furoic acid methyl ester, furfuryl alcohol, furfuryl methyl sulfide, furfuryl mercaptan, 2-methyltetrahydrofuran-3-one and furfuryl methyl ether, and the organic acid is selected from one of acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, enanthic acid, caprylic acid and pelargonic acid.
The preparation method of the slow-release antibacterial mildew-proof composition comprises the following steps:
(1) Preparing a mildew-proof antibacterial mixed solution: mixing the volatile organic matter A with organic acid, adding water and modified starch, and performing vortex treatment to obtain a mixed solution;
(2) Granulating: mixing the mixed solution, the carrier substance and the sodium carboxymethyl cellulose, and granulating by adopting an extrusion method to obtain the slow-release antibacterial and mildew-proof composition.
Comparative example 6
Comparative example 6 was 28 antibacterial substances of 1% concentration by mass of single ingredient, respectively N-furfuryl pyrrole, 4-hydroxy-2, 5-dimethyl-3 (2H) -furanone, methyl furfuryl disulfide, 4- (2-furyl) -3-buten-2-one, difurfuryl ether, 2, 6-dimethylbenzene thiophenol, 3-acetylthio-2-methyl furan, gamma-valerolactone, ethyl levulinate, 2-acetyl-5-methyl furan, tetrahydrofurfuryl alcohol, furfuryl isopropyl sulfide, methyl 2-thiofuroate, 2-acetyl furan, methyl furoate, furfuryl alcohol, furfuryl methyl sulfide, furfuryl mercaptan (also known as caffealdehyde), 2-methyltetrahydrofuran-3-one, furfuryl methyl ether, acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, enanthic acid, caprylic acid, pelargonic acid.
Product effect test
1. Antibacterial effect of slow-release antibacterial mildew-proof composition
In order to facilitate visual evaluation of the antibacterial performance of the slow-release antibacterial and mildew-proof composition, the slow-release antibacterial and mildew-proof composition is tested by adopting a microorganism inhibition zone radius test method.
The bacteriostasis circle method of microorganism is adopted: 20 μl of the slow-release bacteriostatic and mildewproof composition prepared in example 1 was added dropwise to the sterile dried filter paper sheet. The filter paper sheet was placed on a patch inoculated with a concentration of 5X 10 5 -5×10 6 cfu/mL of mold (Aspergillus niger, aspergillus flavus and Penicillium italicum) plates, blank groups were filter paper sheets with 20. Mu.L of distilled water added dropwise. Then the treated plate is placed in a constant temperature incubator at 37 ℃ for culturing for 48-72 hours. The diameter of the zone of inhibition was observed and measured and recorded, the results of which are shown in the following table. Water was used as a blank.
TABLE 3 radius of inhibition zone (unit: mm) for day 1, 30 of slow-release antibacterial and mildew-proof composition
TABLE 4 radius of inhibition zone (unit: mm) on day 1 of sustained release antibacterial mildewproof composition of example 10
From the results, on the 1 st day, the radius of the antibacterial circle of the slow-release antibacterial mildew-proof composition containing the single active ingredient furfural or the derivative thereof is distributed at 15-35mm; containing a single active ingredient C 2 -C 9 The radius of the antibacterial ring of the slow-release antibacterial mildew-proof composition of the organic acid is distributed at 2-10mm; the radius of the inhibition zone of the slow-release antibacterial mildew-proof composition of examples 1-10 is distributed at 18-47mm. It can be seen that the slow-release antibacterial and mildew-proof compositions of examples 1-10 have higher inhibition effect on mildew than single oneThe mildew resistance of the components shows that the organic acid improves the bacteriostatic effect of the slow-release bacteriostatic mildew-resistant composition when the organic acid is mixed with furfural or derivatives thereof.
TABLE 5 radius of inhibition zone (unit: mm) at day 30 of sustained release antibacterial mildewproof composition of example 10
From the results, on the 30 th day, the radius of the single furfural and the derivative mildew-proof antibacterial ring thereof is distributed at 7-34mm; the single organic acid does not show antibacterial effect after being placed for 30 days in a mildew-proof way; the radius of the inhibition zone of the slow-release antibacterial mildew-proof composition prepared in example 10 is distributed between 12 and 47mm. The inhibition effect of the slow-release antibacterial mildew-proof composition on mildew is greatly higher than that of single component after the slow-release antibacterial mildew-proof composition is placed for 30 days, which indicates that the organic acid can improve the antibacterial effect of the slow-release antibacterial mildew-proof composition when the organic acid is mixed with furfural or derivatives thereof.
TABLE 6 percent reduction in zone of inhibition radius (%)
From the above results, it can be seen that the radius of the inhibition zone of the slow-release inhibition mildew-proof composition containing the single active ingredient furfural or the derivative thereof is reduced by 73% at the 30 th day, wherein the radius of the inhibition zone of the slow-release inhibition mildew-proof composition containing more than 50% of the single component is reduced by 15%; the radius of the antibacterial circle of the slow-release antibacterial mildew-proof composition containing single active component organic acid is reduced by 100 percent at 30 days; the radius of the inhibition zone of the slow-release antibacterial and mildew-proof composition is reduced by up to 48%, wherein the radius of the inhibition zone of the slow-release antibacterial and mildew-proof composition exceeding 50% is reduced by less than 20%, and a phenomenon that the radius of the inhibition zone of a small part of slow-release antibacterial and mildew-proof composition is not reduced is shown. After the organic acid is mixed with furfural or derivatives thereof, the organic acid is helpful for prolonging the maintenance time of the antibacterial efficacy of the slow-release antibacterial mildew-proof composition.
2. Mildew-proof effect of slow-release antibacterial mildew-proof composition in food
Toast bread without any additive was made, and individual toasts were slit and filled into heat-sealed bags, each bag having a toast grammage of 20g. Then, the slow-release antibacterial and mildew-proof composition of the embodiment 10 is weighed and respectively placed in the heat-seal bags, and each bag contains 1.5g of the slow-release antibacterial and mildew-proof composition. Each group was stored at room temperature, the amount of the long-noded mold was observed and recorded at different times, and the long-noded mold rates at 15 th and 30 th days were calculated, and the experimental results are shown in the following table.
Table 7 Chang mold rate (%)
From the results, the toast long mould rate of the single furfural and the derivative slow-release antibacterial mould-proof composition is 76% on the 15 th day; wherein, the toast long mould rate of the single organic acid slow-release antibacterial mould-proof composition is up to 100 percent; the sustained-release antibacterial and mildew-proof composition of example 10 has a maximum of 56% of the mould of the toast. And the toast with 40% of the 160 groups of slow-release antibacterial and mildew-proof composition forming agents has no mildew growth phenomenon within 15 days, and the mildew growth rate is 0%. After the organic acid is mixed with furfural or derivatives thereof, the organic acid can improve the inhibition effect of the slow-release antibacterial mildew-proof composition on the mildew in toast.
Table 8 Chang mold rate (%)
From the results, the toast long mould rate of the single furfural and the derivative slow-release antibacterial mould-proof composition of the furfural is up to 88% on the 30 th day; the sustained-release antibacterial and mildew-proof composition of example 10 had a long mold rate of at most 64%, and the toast with 65% of the sustained-release antibacterial and mildew-proof composition in group 160 had a long mold rate of not more than 20% within 30 days, and the toast with 7% of the sustained-release antibacterial and mildew-proof composition forming agent did not show a long mold phenomenon. After the organic acid is mixed with furfural or derivatives thereof, the organic acid can improve the inhibition effect of the slow-release antibacterial mildew-proof composition on the mildew in toast.
3. Mildew-proof effect of slow-release mildew-proof antibacterial composition with different proportions
And (3) testing the antibacterial effect of the slow-release antibacterial mildew-proof composition by adopting a detection method of a microbial inhibition zone on the 1 st day and the 30 th day respectively. Toast bread without any additive was made, and individual toasts were slit and filled into heat-sealed bags, each bag having a toast grammage of 20g. And then respectively weighing the slow-release antibacterial and mildew-proof compositions, respectively placing 1.5g of the slow-release antibacterial and mildew-proof compositions in the heat-seal bags, storing each group at room temperature, observing and recording the amount of the long toast mildew at different time, and calculating the long toast mildew rates at 15 th and 30 th days, wherein the experimental results are shown in the table below.
Table 9 mildew and bacteria inhibiting effects of controlled release mildew and bacteria inhibiting compositions of different ratios
From examination of the results in tables 3 and 9, it is evident from comparative examples 1 to 3 that increasing the content of 2-acetyl-5-methylfuran and hexanoic acid in the mildew-proof antibacterial composition increases the radius of the inhibition zone, and the mildew-proof effect in toast application increases. Comparative example 4 and example 5 increase the ratio of 2-acetyl-5-methyl furan, the slow release mildew-proof antibacterial composition increases the zone radius on the first day, but decreases the zone radius on the 30 th day. In the toast mildew-resistant application, neither toast was mould-proof on day 15, and the mould-proof rate of toast increased on day 30.
Comparative examples 1 to 5 were observed, and comparative examples 1, 2, 4 and 5 all had antibacterial effects in the zone radius test, and comparative example 3 had poor antibacterial effects. Comparative examples 2 and 4, although having a bacteriostatic effect, did not show a good mold-proof effect in toast application. Comparative example 5 has an antibacterial effect, has a good mold-proof effect in toast application, but does not show a mold-inhibiting effect by slow release.
Table 10 mildew and bacteria proofing effects of Furfural and octanoic acid in mildew and bacteria proofing compositions in different ratios
From the above results, comparative examples 6 to 10 keep the total amount of bacteriostatic substances unchanged, increase the proportion of furfural, and increase the radius of the bacteriostatic circle of the mildew-proof bacteriostatic composition on the first day; and then compared with the mildew-proof and bacteriostatic composition with the octanoic acid or the furfural as the bacteriostatic substance in the comparative example 6, the mildew-proof and bacteriostatic composition with the octanoic acid and the furfural can be found that the radius of the bacteriostatic zone of the mildew-proof and bacteriostatic composition with the octanoic acid is larger than that of the single mildew-proof and bacteriostatic composition with the octanoic acid. By increasing the proportion of furfural, the radius of the inhibition zone of the mildew-proof and antibacterial composition on the 30 th day is increased relative to the reduction rate, and the increase amount of the mildew-proof and antibacterial composition on the 30 th day and the 15 th day in toast is increased. Therefore, the antibacterial effect of the mildew-proof antibacterial composition can be improved by increasing the amount of furfural, but the long-term antibacterial effect of the mildew-proof antibacterial composition is reduced along with the reduction of the octanoic acid proportion, which indicates that the organic acid can improve the inhibition effect of the slow-release antibacterial composition on mould in toast.
Claims (11)
1. The slow-release antibacterial mildew-proof composition is characterized by comprising an antibacterial component and a carrier substance, wherein the antibacterial component comprises volatile organic matter A and organic acid;
the volatile organic compound A is furfural and/or furfural derivatives;
the organic acid is one or more of acetic acid, propionic acid, butyric acid, valeric acid, caproic acid, heptanoic acid, caprylic acid and nonanoic acid.
2. The slow-release antibacterial and mildew-proof composition according to claim 1, wherein the molar ratio of volatile organic compound a to organic acid is 1:0.1-10.
3. The slow-release antibacterial and mildew-proof composition according to claim 1, comprising the following components in percentage by mass:
0.05-10% of volatile organic matter A, 0.05-10% of organic acid and 80-99% of carrier material.
4. The sustained-release antibacterial and mildewproof composition according to claim 1, wherein the furfural derivative is one or more of N-furfurylpyrrole, 4-hydroxy-2, 5-dimethyl-3 (2H) -furanone, methylfurfuryl disulfide, 4- (2-furyl) -3-buten-2-one, difurfuryl ether, 2, 6-dimethylbenzene thiophenol, 3-acetylthio-2-methyl furan, gamma valerolactone, ethyl levulinate, 2-acetyl-5-methyl furan, tetrahydrofurfuryl alcohol, furfuryl isopropyl sulfide, 2-thiofuroic acid methyl ester, 2-acetyl furan, furfuryl methyl ester, furfuryl alcohol, furfuryl methyl sulfide, furfuryl mercaptan, 2-methyltetrahydrofuran-3-one, furfuryl methyl ether.
5. The slow-release antibacterial and mildew-proof composition according to claim 1, wherein the carrier material is one or more of zeolite, diatomite, quartz sand and natural high molecular polysaccharide.
6. The slow-release antibacterial and mildew-proof composition according to claim 1, wherein the slow-release antibacterial and mildew-proof composition is one of granules, pills, active films and tablets.
7. The slow-release bacteriostatic and mildew-resistant composition according to claim 1, further comprising water and an auxiliary agent.
8. A slow release bacteriostatic and mildewproof composition according to claim 1 wherein said adjuvants include emulsifiers and/or binders.
9. A method for preparing a slow-release bacteriostatic and mildewproof composition as claimed in any one of claims 1 to 8, which is characterized by comprising the following steps:
and mixing the components, and forming to obtain the slow-release antibacterial mildew-proof composition.
10. Use of a slow-release bacteriostatic and mildew-proof composition according to any one of claims 1-8 in the field of bacteriostatic and mildew-proof of food.
11. A bacteriostatic and mildew-proof method for prolonging the shelf life of food, characterized by comprising the following steps:
a slow release bacteriostatic and mildew-resistant composition according to any one of claims 1 to 8, which is placed inside a food packaging bag.
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| CN116850789B (en) * | 2023-09-05 | 2024-01-02 | 杭州尚善若水环保科技有限公司 | Cleaning agent mixture and application thereof in cleaning reverse osmosis membrane |
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