CN116508017A - 计算药物靶标选择 - Google Patents

计算药物靶标选择 Download PDF

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Publication number
CN116508017A
CN116508017A CN202180074273.9A CN202180074273A CN116508017A CN 116508017 A CN116508017 A CN 116508017A CN 202180074273 A CN202180074273 A CN 202180074273A CN 116508017 A CN116508017 A CN 116508017A
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China
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public
drug
target
drug target
character
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Chinese (zh)
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丹尼尔·詹姆斯·克劳瑟
大卫·纳加内斯·卡隆
吉列尔莫·塞拉诺·纳赫拉
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Aix Saianxia Artificial Intelligence Co ltd
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Aix Saianxia Artificial Intelligence Co ltd
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H70/00—ICT specially adapted for the handling or processing of medical references
    • G16H70/40—ICT specially adapted for the handling or processing of medical references relating to drugs, e.g. their side effects or intended usage
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F16/00—Information retrieval; Database structures therefor; File system structures therefor
    • G06F16/30—Information retrieval; Database structures therefor; File system structures therefor of unstructured textual data
    • G06F16/33—Querying
    • G06F16/332—Query formulation
    • G06F16/3325—Reformulation based on results of preceding query
    • G06F16/3326—Reformulation based on results of preceding query using relevance feedback from the user, e.g. relevance feedback on documents, documents sets, document terms or passages
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F16/00—Information retrieval; Database structures therefor; File system structures therefor
    • G06F16/30—Information retrieval; Database structures therefor; File system structures therefor of unstructured textual data
    • G06F16/35—Clustering; Classification
    • G06F16/353—Clustering; Classification into predefined classes
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F16/00—Information retrieval; Database structures therefor; File system structures therefor
    • G06F16/30—Information retrieval; Database structures therefor; File system structures therefor of unstructured textual data
    • G06F16/35—Clustering; Classification
    • G06F16/355—Creation or modification of classes or clusters
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F16/00—Information retrieval; Database structures therefor; File system structures therefor
    • G06F16/30—Information retrieval; Database structures therefor; File system structures therefor of unstructured textual data
    • G06F16/38—Retrieval characterised by using metadata, e.g. metadata not derived from the content or metadata generated manually
    • G06F16/382—Retrieval characterised by using metadata, e.g. metadata not derived from the content or metadata generated manually using citations
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F16/00—Information retrieval; Database structures therefor; File system structures therefor
    • G06F16/90—Details of database functions independent of the retrieved data types
    • G06F16/93—Document management systems
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F40/00—Handling natural language data
    • G06F40/20—Natural language analysis
    • G06F40/279—Recognition of textual entities
    • G06F40/289—Phrasal analysis, e.g. finite state techniques or chunking
    • G06F40/295—Named entity recognition
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N20/00—Machine learning
    • G06N20/10—Machine learning using kernel methods, e.g. support vector machines [SVM]
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    • G06—COMPUTING OR CALCULATING; COUNTING
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    • G06N20/00—Machine learning
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    • G06N3/044—Recurrent networks, e.g. Hopfield networks
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    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
    • G06N3/044—Recurrent networks, e.g. Hopfield networks
    • G06N3/0442—Recurrent networks, e.g. Hopfield networks characterised by memory or gating, e.g. long short-term memory [LSTM] or gated recurrent units [GRU]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
    • G06N3/045—Combinations of networks
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
    • G06N3/045—Combinations of networks
    • G06N3/0455—Auto-encoder networks; Encoder-decoder networks
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/08—Learning methods
    • G06N3/088—Non-supervised learning, e.g. competitive learning
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/08—Learning methods
    • G06N3/0895—Weakly supervised learning, e.g. semi-supervised or self-supervised learning
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/08—Learning methods
    • G06N3/09—Supervised learning
    • G—PHYSICS
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    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/08—Learning methods
    • G06N3/091—Active learning
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/70—Machine learning, data mining or chemometrics
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H70/00—ICT specially adapted for the handling or processing of medical references
    • G16H70/20—ICT specially adapted for the handling or processing of medical references relating to practices or guidelines

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  • Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Data Mining & Analysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Artificial Intelligence (AREA)
  • Software Systems (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Evolutionary Computation (AREA)
  • Medical Informatics (AREA)
  • Databases & Information Systems (AREA)
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  • Computing Systems (AREA)
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  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Chemical & Material Sciences (AREA)
  • Primary Health Care (AREA)
  • Bioethics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Audiology, Speech & Language Pathology (AREA)
  • Business, Economics & Management (AREA)
  • General Business, Economics & Management (AREA)
  • Library & Information Science (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
CN202180074273.9A 2020-10-29 2021-10-29 计算药物靶标选择 Pending CN116508017A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2017177.3 2020-10-29
GB2017177.3A GB2600687A (en) 2020-10-29 2020-10-29 Computational drug target selection
PCT/GB2021/052813 WO2022096861A2 (en) 2020-10-29 2021-10-29 Computational drug target selection

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Publication Number Publication Date
CN116508017A true CN116508017A (zh) 2023-07-28

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US (1) US20230352193A1 (https=)
EP (1) EP4238097A2 (https=)
JP (1) JP2023547964A (https=)
KR (1) KR20230128266A (https=)
CN (1) CN116508017A (https=)
GB (1) GB2600687A (https=)
WO (1) WO2022096861A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202304213D0 (en) 2023-03-23 2023-05-10 Exscientia Ai Ltd Computational drug target selection
KR20250045561A (ko) 2023-09-25 2025-04-02 주식회사 엘지에너지솔루션 충전 관리 장치 및 그것의 동작 방법

Citations (2)

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Publication number Priority date Publication date Assignee Title
CN107533563A (zh) * 2015-05-29 2018-01-02 英特尔公司 用于动态自动化内容发现的技术
CN108427702A (zh) * 2017-10-23 2018-08-21 平安科技（深圳）有限公司 目标文档获取方法及应用服务器

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JP5347878B2 (ja) * 2009-09-29 2013-11-20 富士通株式会社 文献間関係解析装置、該プログラム、及び該方法
CN109074420B (zh) * 2016-05-12 2022-03-08 豪夫迈·罗氏有限公司 用于预测靶向药物治疗疾病的效果的系统
JP7237574B2 (ja) * 2018-12-27 2023-03-13 オムロンヘルスケア株式会社 血圧測定装置
US11721441B2 (en) * 2019-01-15 2023-08-08 Merative Us L.P. Determining drug effectiveness ranking for a patient using machine learning

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107533563A (zh) * 2015-05-29 2018-01-02 英特尔公司 用于动态自动化内容发现的技术
CN108427702A (zh) * 2017-10-23 2018-08-21 平安科技（深圳）有限公司 目标文档获取方法及应用服务器

Non-Patent Citations (5)

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BOB JA SCHIJVENAARS ET AL.: "Thesaurus-based disambiguation of gene symbols", 《BMC BIOINFORMATICS》, vol. 6, 16 June 2005 (2005-06-16), pages 1 - 9 *
FARAG SAAD ET AL.: "Improving Named Entity Recognition for Biomedical and Patent Data Using Bi-LSTM Deep Neural Network Models", 《NLDB 2020》, 17 July 2020 (2020-07-17), pages 25 - 26 *
MARTIN KRALLINGER ET AL.: ""Information Retrieval and Text Mining Technologies for Chemistry"", 《CHEMICAL REVIEWS》, vol. 117, no. 12, 5 May 2017 (2017-05-05), pages 7726 - 7736 *
QI WANG: ""A Bibiliometric Model for Identifying Emerging Research Topics"", HTTPS://ARXIV.ORG/ABS/1707.03599, 12 July 2017 (2017-07-12), pages 2 - 9 *
UDO HAHN ET AL.: "Mining the pharmacogenomics literatureça survey of the state of the art", 《BRIEFINGS IN BIOINFORMATICS》, vol. 3, no. 4, 24 July 2012 (2012-07-24), pages 460 - 494 *

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GB202017177D0 (en) 2020-12-16
JP2023547964A (ja) 2023-11-14
GB2600687A (en) 2022-05-11
US20230352193A1 (en) 2023-11-02
KR20230128266A (ko) 2023-09-04
WO2022096861A3 (en) 2022-08-25
EP4238097A2 (en) 2023-09-06
WO2022096861A2 (en) 2022-05-12

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