CN116430042B - Simple nasopharyngeal swab antigen detection device and detection method - Google Patents
Simple nasopharyngeal swab antigen detection device and detection method Download PDFInfo
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- CN116430042B CN116430042B CN202310400109.3A CN202310400109A CN116430042B CN 116430042 B CN116430042 B CN 116430042B CN 202310400109 A CN202310400109 A CN 202310400109A CN 116430042 B CN116430042 B CN 116430042B
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- 238000001514 detection method Methods 0.000 title claims abstract description 61
- 239000000427 antigen Substances 0.000 title claims abstract description 42
- 102000036639 antigens Human genes 0.000 title claims abstract description 42
- 108091007433 antigens Proteins 0.000 title claims abstract description 42
- 239000007788 liquid Substances 0.000 claims abstract description 62
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 57
- 238000003786 synthesis reaction Methods 0.000 claims abstract description 57
- 238000003860 storage Methods 0.000 claims abstract description 33
- 238000002955 isolation Methods 0.000 claims abstract description 19
- 235000009161 Espostoa lanata Nutrition 0.000 claims abstract description 13
- 240000001624 Espostoa lanata Species 0.000 claims abstract description 13
- 238000000197 pyrolysis Methods 0.000 claims abstract description 8
- 238000002347 injection Methods 0.000 claims abstract description 5
- 239000007924 injection Substances 0.000 claims abstract description 5
- 238000005070 sampling Methods 0.000 claims description 23
- 229920000742 Cotton Polymers 0.000 claims description 14
- 230000002194 synthesizing effect Effects 0.000 claims description 12
- 239000006166 lysate Substances 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 238000007789 sealing Methods 0.000 claims description 5
- 210000003928 nasal cavity Anatomy 0.000 claims description 4
- 239000012780 transparent material Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 239000007779 soft material Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000004448 titration Methods 0.000 abstract description 9
- 241000700605 Viruses Species 0.000 abstract description 6
- 239000000243 solution Substances 0.000 description 12
- 241000711573 Coronaviridae Species 0.000 description 5
- 230000009089 cytolysis Effects 0.000 description 5
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 3
- 235000017491 Bambusa tulda Nutrition 0.000 description 3
- 241001330002 Bambuseae Species 0.000 description 3
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 3
- 239000011425 bamboo Substances 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000005336 cracking Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 210000002345 respiratory system Anatomy 0.000 description 2
- 238000004891 communication Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000002906 medical waste Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/165—Coronaviridae, e.g. avian infectious bronchitis virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/10—Detection of antigens from microorganism in sample from host
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a simple nasopharyngeal swab antigen detection device and a detection method, belonging to the technical field of biological detection; the device comprises a sample synthesis cylinder, a supporting body, antigen detection test paper and a liquid storage tube, wherein the sample synthesis cylinder is provided with a cylinder cover, and a sample injection hole and a connecting hole are formed in the cylinder cover; the bearing body is arranged in the connecting hole and can move along the depth direction of the connecting hole, and a first accommodating groove and a second accommodating groove are formed in the bearing body; the antigen detection test paper is arranged in the second accommodating groove, one end of the antigen detection test paper, which is close to the sample synthesis barrel, is provided with an isolation film, the isolation film is positioned at the opening of the second accommodating groove, the bottom of the inner barrel of the sample synthesis barrel is provided with a sharp bulge, and the isolation film is positioned below the isolation film; one end of the liquid storage tube, which is arranged in the sample synthesis cylinder, is provided with a cotton ball, the other end of the liquid storage tube is provided with a liquid inlet control structure, and the liquid storage tube is filled with pyrolysis liquid; the invention can effectively solve the problem that the accurate result is not detected and the virus is diffused because the extracted liquid is easily dripped outside the sample titration area.
Description
Technical Field
The invention relates to the technical field of biological detection, in particular to a simple nasopharyngeal swab antigen detection device and a detection method.
Background
Coronaviruses are NA viruses with envelope and linear single-strand positive strand genome, and are a large class of viruses widely existing in nature, and are mainly transmitted through respiratory tract droplets, respiratory tract secretions and direct contact.
The novel coronavirus antigen detection kit is one of the main detection means at the present stage, the principle is mainly to utilize the principle of specific binding of antigen and antibody, and the antigen can be detected through the antibody, so that the detection of new coronavirus in a sample is proved, the novel coronavirus detection kit sold on the market based on the principle is made of a plurality of types, the existing coronavirus detection kit sold on the market is a manual handheld disposable sampler, after sampling, a lysate is firstly put into to prepare an extracting solution, then the extracting solution is dripped into a sample titration area of an antigen detection reagent card, and due to the fact that the sample titration area of the antigen detection reagent card is smaller, when a detection staff has slight shaking of arms, the extracting solution is likely to be dripped out of the sample titration area, so that the detection of incorrect results is caused, viruses are likely to be contained in the extracting solution dripped out of the sample titration area, and the viruses are likely to be diffused. Meanwhile, the used sampling cotton stick is used as medical waste, and secondary pollution can be caused by improper treatment operation.
The foregoing background is only for the purpose of facilitating an understanding of the principles and concepts of the invention and is not necessarily in the prior art to the present application and is not intended to be used as an admission that such background is not entitled to antedate such novelty and creativity by the present application without undue evidence prior to the present application.
Disclosure of Invention
It is an object of the present disclosure to provide a simple nasopharyngeal swab antigen detection device that overcomes at least one of the drawbacks of the prior art.
In order to solve the technical problems, the embodiment of the application discloses the following technical scheme:
a simple nasopharyngeal swab antigen detection device, comprising:
the sample synthesis cylinder is provided with a cylinder cover, and a sample injection hole and a connecting hole are formed in the cylinder cover;
the bearing body is arranged in the connecting hole and can move along the depth direction of the connecting hole, and a first accommodating groove and a second accommodating groove are formed in the bearing body;
the antigen detection test paper is arranged in the second accommodating groove, an isolation film is arranged at one end of the antigen detection test paper, which is close to the sample synthesis barrel, the isolation film is positioned at the opening of the second accommodating groove, a sharp bulge is arranged on the bottom of the inner barrel of the sample synthesis barrel, and the isolation film is positioned below the isolation film;
and one end of the liquid storage tube, which is arranged in the sample synthesis cylinder, is provided with a cotton ball, the other end of the liquid storage tube is provided with a liquid inlet control structure, and the liquid storage tube is filled with pyrolysis liquid.
Preferably, the embodiment of the application further discloses: the sample inlet is provided with a rubber plug.
Preferably, the embodiment of the application further discloses: the simple nasopharyngeal swab antigen detection device further comprises: and when the sampling cotton stick is completely sampled, the sampling cotton stick extends into the sample synthesizing cylinder through the sample inlet.
Preferably, the embodiment of the application further discloses: the bottom of the supporting body is a columnar body, external threads are arranged on the columnar body, and internal threads matched with the external threads on the columnar body are arranged on the hole wall of the connecting hole.
Preferably, the embodiment of the application further discloses: the column body is also provided with a first limiting ring and a second limiting ring, the second limiting ring is far away from the sample synthesis barrel compared with the first limiting ring, and the manufacturing material of the first limiting ring is brittle material.
Preferably, the embodiment of the application further discloses: the liquid inlet control structure is a sealing cover.
Preferably, the embodiment of the application further discloses: the liquid storage tube is far away from one end of the sample synthesis barrel is sealed, and the liquid inlet control structure is as follows: and the breaking nicks are arranged on the outer wall of the liquid storage tube.
Preferably, the embodiment of the application further discloses: the bottom wall of the sample synthesis barrel is made of hard materials, and the middle part of the circumferential side wall of the sample synthesis barrel is made of soft materials.
Preferably, the embodiment of the application further discloses: the sample synthesis cylinder is made of transparent materials.
The detection method adopting the simple nasopharyngeal swab antigen detection device comprises the following steps of:
s1, a sampling cotton stick subjected to nasal cavity sampling enters the inside of a sample synthesizing cylinder from a sample inlet of a cylinder cover; the cracking liquid flows out of the liquid storage tube and falls into the sample synthesizing cylinder by utilizing the liquid inlet control structure;
s2, screwing the columnar body of the supporting body into the connecting hole, screwing the columnar body into a position abutting against the first limiting ring, and then extruding the soft wall of the sample synthesis barrel to enable the pyrolysis liquid on the cotton ball of the liquid storage pipe to fully fall into the sample synthesis barrel;
s3, screwing the columnar body of the supporting body to a position abutting against the second limiting ring, so that the sharp protrusions on the bottom wall of the inside of the sample synthesis cylinder destroy the isolation film, and the lysate inside the sample synthesis cylinder is fully contacted with the antigen detection test paper to finish detection.
One or more technical solutions provided in the embodiments of the present application at least have the following technical effects or advantages:
in the embodiment of the application, nasal cavity sampling can be performed through the sampling cotton stick, and the sampled sampling cotton stick enters the sample synthesizing cylinder from the sample injection hole of the cylinder cover; and the lysate flows out of the liquid storage tube and falls into the sample synthesis tube by utilizing the liquid inlet control structure. Then the columnar body of the bearing body is screwed into the connecting hole and is screwed to the position abutting against the first limiting ring, and then the soft wall is extruded, so that the pyrolysis liquid on the cotton ball of the liquid storage tube fully falls into the sample synthesis cylinder. And screwing the columnar body of the supporting body to a position abutting against the second limiting ring, so that the sharp protrusions on the bottom wall of the inside of the sample synthesis cylinder destroy the isolation film, and the lysate inside the sample synthesis cylinder is fully contacted with the antigen detection test paper to finish detection. Therefore, the problem that the virus is easy to spread due to incorrect detection caused by the fact that the extraction liquid drops to the sample titration area without manual operation can be effectively solved, the problem that the sample titration area is smaller due to the fact that the antigen detection reagent card is slightly shaken when the arms of detection personnel appear, and the sample titration area is possibly dripped with the extraction liquid is solved, and in addition, the sample cotton stick can be detected without being taken out, so that other objects can be effectively prevented from being polluted due to the sample cotton stick taken out of the lysis solution.
In conclusion, compared with the prior art, the method is simpler and more convenient to operate, and meanwhile, the problem that accurate detection results cannot be obtained due to the fact that extraction liquid is easily dripped outside a sample titration zone is effectively solved.
In this application embodiment, the sample introduction hole is furnished with the rubber stopper, can effectively keep the inside of sample synthetic section of thick bamboo not polluted by the outside.
In this application embodiment, sample synthetic section of thick bamboo adopts transparent material preparation to form, conveniently observes the inside of sample synthetic section of thick bamboo, carries out the sampling operation.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions of the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it being understood that like reference numerals denote like elements throughout the drawings. In the drawings, the dimensions of some of the features may be modified for clarity of understanding.
FIG. 1 is a schematic diagram of a simple nasopharyngeal swab antigen detection device according to an embodiment of the present invention;
fig. 2 is a schematic structural view of a carrier according to an embodiment of the present invention;
fig. 3 is a top view of a carrier in an embodiment of the invention;
fig. 4 is a sectional view of B-B in fig. 3.
FIG. 5 is a schematic view of a sample synthesizing cartridge according to an embodiment of the present invention;
FIG. 6 is a schematic top view of a sample synthesis cartridge according to an embodiment of the present invention;
fig. 7 is a cross-sectional view A-A of fig. 6.
Reference numerals illustrate:
10. a sample synthesis cartridge; 11. a cylinder cover; 111. a sample inlet; 112. a connection hole; 12. a sharp protrusion; 20. a carrier; 201. a first accommodating groove; 202. a second accommodating groove; 203. a separation film; 204. a columnar body; 205. a first stop collar; 206. a second limiting ring; 30. antigen detection test paper; 31. a liquid storage tube; 311. sealing cover; 312. cotton ball.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It should be noted that, in the description of the present invention, terms such as "medium," "upper," "lower," "transverse," "inner," and the like indicate directions or positional relationships based on the directions or positional relationships shown in the drawings, which are merely for convenience of description, and do not indicate or imply that the apparatus or elements must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present invention.
Furthermore, it should be noted that, in the description of the present invention, unless explicitly specified and limited otherwise, the terms "disposed," "mounted," "connected" and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; may be a mechanical connection; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention can be understood by those skilled in the art according to the specific circumstances.
Examples:
referring to fig. 1-7, this embodiment discloses a simple nasopharyngeal swab antigen detection device, comprising: the sample synthesis tube 10, the carrier 20, the antigen detection test paper 30 and the liquid storage tube 31, wherein the sample synthesis tube 10 is provided with a tube cover 11, the tube cover 11 is detachably arranged on the sample synthesis tube 10 through the matching of internal threads and external threads, and the tube cover 11 is provided with a sample injection hole 111 and a connecting hole 112; the supporting body 20 is installed in the connecting hole 112 and can move along the hole depth direction of the connecting hole 112, and a first accommodating groove 201 and a second accommodating groove 202 are formed on the supporting body 20; the antigen detection test paper 30 is arranged in the second accommodating groove 202, an isolation film 203 is arranged at one end of the antigen detection test paper 30, which is close to the sample synthesis barrel 10, the isolation film 203 is positioned at the opening of the second accommodating groove 202, a sharp protrusion 12 is arranged on the inner barrel bottom of the sample synthesis barrel 10, and is positioned below the isolation film 203; the cotton ball 312 is arranged at one end of the liquid storage tube 31 in the sample synthesis barrel 10, the liquid inlet control structure is arranged at the other end of the liquid storage tube 31, the cracking liquid is contained in the liquid storage tube 31, the cross section of the second containing groove 202 in the depth direction is inconsistent, the cross section close to the opening is circular, the isolating film 203 is convenient to destroy, and the cross section of other parts can be determined according to the cross section of the antigen detection test paper 30.
The sample inlet 111 is provided with a rubber plug or other cover, so that the inside of the sample synthesizing cylinder 10 can be effectively kept from being polluted by the outside.
The simple nasopharyngeal swab antigen detection device further comprises: the sampling cotton stick extends into the sample synthesizing cylinder 10 through the sampling hole 111 when the sampling cotton stick is sampled.
Referring to fig. 3, the bottom end of the supporting body 20 is a cylindrical body 204, an external thread is provided on the cylindrical body 204, and an internal thread matching with the external thread on the cylindrical body 204 is provided on the wall of the connecting hole 112, so that the supporting body 20 can move along the depth direction of the connecting hole 112.
Referring to fig. 3, the column 204 is further provided with a first stop collar 205 and a second stop collar 206, the second stop collar 206 is further away from the sample synthesis tube 10 than the first stop collar 205, the first stop collar 205 is made of a brittle material, when the tube cover 11 abuts against the first stop collar 205, the column 204 continues to be screwed into the sample synthesis tube 10, the first stop collar 205 is damaged, and is completely separated from the column 204, so that the column 204 is not hindered from being screwed into.
Referring to fig. 1 and fig. 4, in some embodiments, the liquid inlet control structure is a sealing cover 311, when in use, the sealing cover 311 is unscrewed, and the pressure difference between the atmospheric pressure and the pressure in the liquid storage tube 31 is used to make the pyrolysis liquid enter the cotton ball 312 at the other end, which should be noted as follows: the liquid storage tube 31 stores a large amount of the lysis solution, and the cotton ball 312 adsorbs only a part of the lysis solution, and a large part of the lysis solution flows into the sample synthesis cartridge 10. Of course, in other embodiments, the end of the liquid storage tube 31 away from the sample synthesis cartridge 10 may be sealed, and the liquid inlet control structure is implemented as follows: the breaking notch is arranged on the outer wall of the liquid storage tube 31, and when in use, one end of the liquid storage tube 31 is broken along the breaking notch, so that air enters the liquid storage tube 31, and the cracking liquid enters the cotton ball 312 at the other end by utilizing the difference between the atmospheric pressure and the air pressure in the liquid storage tube 31.
The bottom wall of the sample synthesis barrel 10 is made of hard materials, and the middle part of the circumferential side wall of the sample synthesis barrel 10 is made of soft materials, so that the pyrolysis liquid adsorbed on the cotton balls 312 is conveniently extruded into the sample synthesis barrel 10, and waste is reduced.
The sample synthesizing cylinder 10 is made of transparent materials, so that the inside of the sample synthesizing cylinder 10 can be conveniently observed, and sampling operation can be performed.
The embodiment also discloses a detection method of the simple nasopharyngeal swab antigen detection device, which comprises the following steps:
s1, a sampling cotton stick subjected to nasal cavity sampling enters the inside of a sample synthesizing barrel 10 from a sampling hole 111 of a barrel cover; the lysate is flowed out of the reservoir 31 into the sample synthesis cartridge 10 by the liquid inlet control structure.
S2, screwing the columnar body 204 of the carrier 20 into the connecting hole 112 to a position abutting against the first limiting ring 205, and then squeezing the soft wall of the sample synthesis barrel 10 to enable the lysis solution on the cotton ball 312 of the liquid storage tube 31 to fully fall into the sample synthesis barrel 10.
S3, screwing the columnar body 204 of the carrier 20 to a position abutting against the second limiting ring 206, so that the sharp protrusions 12 on the bottom wall of the interior of the sample synthesis barrel 10 destroy the isolation film 203, and the lysate in the interior of the sample synthesis barrel 10 is fully contacted with the antigen detection test paper 30 to complete detection.
The invention and its embodiments have been described above with no limitation, and the actual construction is not limited to the embodiments of the invention as shown throughout. In summary, if one of ordinary skill in the art is informed by this disclosure, a structural manner and an embodiment similar to the technical solution should not be creatively devised without departing from the gist of the present invention.
Claims (6)
1. A simple nasopharyngeal swab antigen detection device, which is characterized in that: comprising the following steps:
a sample synthesis barrel (10), wherein the sample synthesis barrel (10) is provided with a barrel cover (11), and a sample injection hole (111) and a connecting hole (112) are formed in the barrel cover (11);
the supporting body (20), the supporting body (20) is installed in the connecting hole (112) and can move along the hole depth direction of the connecting hole (112), and a first accommodating groove (201) and a second accommodating groove (202) are formed in the supporting body (20);
the antigen detection test paper (30), the antigen detection test paper (30) is arranged in the second accommodating groove (202), an isolation film (203) is arranged at one end of the antigen detection test paper (30) close to the sample synthesis barrel (10), the isolation film (203) is positioned at the opening of the second accommodating groove (202), a sharp protrusion (12) is arranged on the inner barrel bottom of the sample synthesis barrel (10), and the isolation film is positioned below the isolation film (203);
a liquid storage tube (31), wherein one end of the liquid storage tube (31) arranged in the sample synthesis cylinder (10) is provided with a cotton ball (312), the other end is provided with a liquid inlet control structure, and the liquid storage tube (31) is filled with a pyrolysis liquid;
the bottom end of the supporting body (20) is a columnar body (204), an external thread is arranged on the columnar body (204), an internal thread matched with the external thread on the columnar body (204) is arranged on the hole wall of the connecting hole (112), a first limiting ring (205) and a second limiting ring (206) are further arranged on the columnar body (204), the second limiting ring (206) is far away from the sample synthesis barrel (10) compared with the first limiting ring (205), and the manufacturing material of the first limiting ring (205) is a brittle material;
one end of the liquid storage tube (31) far away from the sample synthesis barrel (10) is sealed, and the liquid inlet control structure is as follows: a breaking notch arranged on the outer wall of the liquid storage tube (31); the bottom wall of the sample synthesis barrel (10) is made of a hard material, and the middle part of the circumferential side wall of the sample synthesis barrel (10) is made of a soft material.
2. The simple nasopharyngeal swab antigen detection device as claimed in claim 1, wherein: the sample inlet (111) is provided with a rubber plug.
3. A simple nasopharyngeal swab antigen detection device as claimed in claim 1 or claim 2, wherein: the simple nasopharyngeal swab antigen detection device further comprises: and when the sampling of the sampling cotton stick is finished, the sampling cotton stick extends into the sample synthesizing cylinder (10) through the sample inlet (111).
4. The simple nasopharyngeal swab antigen detection device as claimed in claim 1, wherein: the liquid inlet control structure is a sealing cover (311).
5. The simple nasopharyngeal swab antigen detection device as claimed in claim 1, wherein: the sample synthesis barrel (10) is made of transparent materials.
6. A method of detecting using the simple nasopharyngeal swab antigen detection apparatus of claim 1, wherein: the method comprises the following steps:
s1, a sampling cotton stick subjected to nasal cavity sampling enters the inside of a sample synthesizing cylinder (10) from a sampling hole (111) of a cylinder cover; the lysate flows out of the liquid storage tube (31) and falls into the sample synthesis tube (10) by utilizing the liquid inlet control structure;
s2, screwing the columnar body (204) of the supporting body (20) into the connecting hole (112) to a position where the columnar body is abutted against the first limiting ring (205), and then extruding the soft wall of the sample synthesis barrel (10) to enable the pyrolysis liquid on the cotton ball (312) of the liquid storage tube (31) to fully fall into the sample synthesis barrel (10);
s3, screwing the columnar body (204) of the supporting body (20) to a position abutting against the second limiting ring (206) to enable the sharp protrusions (12) on the bottom wall of the interior of the sample synthesis barrel (10) to destroy the isolation film (203), and enabling the lysate in the interior of the sample synthesis barrel (10) to fully contact with the antigen detection test paper (30) to finish detection.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202310400109.3A CN116430042B (en) | 2023-04-14 | 2023-04-14 | Simple nasopharyngeal swab antigen detection device and detection method |
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| CN202310400109.3A CN116430042B (en) | 2023-04-14 | 2023-04-14 | Simple nasopharyngeal swab antigen detection device and detection method |
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| CN116430042B true CN116430042B (en) | 2024-04-05 |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6248294B1 (en) * | 1998-04-15 | 2001-06-19 | Frederic L. Nason | Self contained diagnostic test unit |
| WO2012000734A1 (en) * | 2010-05-31 | 2012-01-05 | Copan Italia S.P.A. | Test kit |
| JP2017026554A (en) * | 2015-07-27 | 2017-02-02 | Ｓｏｌｉｚｅ株式会社 | Specimen sampling tool, detection container and inspection device |
| CN211402158U (en) * | 2020-07-29 | 2020-09-01 | 南京黎明生物制品有限公司 | Reagent strip device of dual biological safety protection |
| KR102264289B1 (en) * | 2020-10-15 | 2021-06-15 | 이호진 | Sample insertion type diagnostic kit |
| CN113484514A (en) * | 2021-03-25 | 2021-10-08 | 江苏硕世生物科技股份有限公司 | Test paper detection auxiliary device |
| WO2022099757A1 (en) * | 2020-11-11 | 2022-05-19 | 南京黎明生物制品有限公司 | Test strip processing apparatus |
| CN218727334U (en) * | 2022-10-17 | 2023-03-24 | 青岛菩提慧生医学检验有限公司 | Novel coronavirus detection kit |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050106753A1 (en) * | 2003-07-11 | 2005-05-19 | Oakville Trading Hong Kong Limited | Sanitary fluid collection, application and storage device and methods of use of same |
| US20230037035A1 (en) * | 2021-07-27 | 2023-02-02 | Taiwan Swabs Technology Company | Biochemical detection device |
-
2023
- 2023-04-14 CN CN202310400109.3A patent/CN116430042B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6248294B1 (en) * | 1998-04-15 | 2001-06-19 | Frederic L. Nason | Self contained diagnostic test unit |
| WO2012000734A1 (en) * | 2010-05-31 | 2012-01-05 | Copan Italia S.P.A. | Test kit |
| JP2017026554A (en) * | 2015-07-27 | 2017-02-02 | Ｓｏｌｉｚｅ株式会社 | Specimen sampling tool, detection container and inspection device |
| CN211402158U (en) * | 2020-07-29 | 2020-09-01 | 南京黎明生物制品有限公司 | Reagent strip device of dual biological safety protection |
| KR102264289B1 (en) * | 2020-10-15 | 2021-06-15 | 이호진 | Sample insertion type diagnostic kit |
| WO2022099757A1 (en) * | 2020-11-11 | 2022-05-19 | 南京黎明生物制品有限公司 | Test strip processing apparatus |
| CN113484514A (en) * | 2021-03-25 | 2021-10-08 | 江苏硕世生物科技股份有限公司 | Test paper detection auxiliary device |
| CN218727334U (en) * | 2022-10-17 | 2023-03-24 | 青岛菩提慧生医学检验有限公司 | Novel coronavirus detection kit |
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