CN116421468B - Composite probiotics preparation device and preparation process thereof - Google Patents
Composite probiotics preparation device and preparation process thereof Download PDFInfo
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- CN116421468B CN116421468B CN202310710219.XA CN202310710219A CN116421468B CN 116421468 B CN116421468 B CN 116421468B CN 202310710219 A CN202310710219 A CN 202310710219A CN 116421468 B CN116421468 B CN 116421468B
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- 239000006041 probiotic Substances 0.000 title claims abstract description 110
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 110
- 239000002131 composite material Substances 0.000 title claims abstract description 93
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 239000007788 liquid Substances 0.000 claims abstract description 121
- 230000000529 probiotic effect Effects 0.000 claims abstract description 84
- 239000007921 spray Substances 0.000 claims abstract description 55
- 239000011248 coating agent Substances 0.000 claims abstract description 52
- 238000000576 coating method Methods 0.000 claims abstract description 52
- 239000000243 solution Substances 0.000 claims abstract description 44
- 238000005507 spraying Methods 0.000 claims abstract description 25
- 238000001514 detection method Methods 0.000 claims abstract description 22
- 241000193749 Bacillus coagulans Species 0.000 claims abstract description 18
- 229940054340 bacillus coagulans Drugs 0.000 claims abstract description 18
- 238000010438 heat treatment Methods 0.000 claims abstract description 16
- 239000007864 aqueous solution Substances 0.000 claims abstract description 13
- 239000000843 powder Substances 0.000 claims abstract description 12
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000002156 mixing Methods 0.000 claims abstract description 10
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract description 5
- 239000000835 fiber Substances 0.000 claims abstract description 5
- 229960003531 phenolsulfonphthalein Drugs 0.000 claims abstract description 5
- 230000007246 mechanism Effects 0.000 claims description 58
- 230000007306 turnover Effects 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 238000012544 monitoring process Methods 0.000 claims description 10
- 230000001276 controlling effect Effects 0.000 claims description 9
- 239000003638 chemical reducing agent Substances 0.000 claims description 8
- 238000001704 evaporation Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 238000011161 development Methods 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000004083 survival effect Effects 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 230000008020 evaporation Effects 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 230000000149 penetrating effect Effects 0.000 claims 1
- 241000894006 Bacteria Species 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 3
- 239000001856 Ethyl cellulose Substances 0.000 description 5
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 5
- 229920001249 ethyl cellulose Polymers 0.000 description 5
- 235000019325 ethyl cellulose Nutrition 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000012266 salt solution Substances 0.000 description 2
- 241000186018 Bifidobacterium adolescentis Species 0.000 description 1
- 241000186016 Bifidobacterium bifidum Species 0.000 description 1
- 241000186012 Bifidobacterium breve Species 0.000 description 1
- 241001608472 Bifidobacterium longum Species 0.000 description 1
- 241000186015 Bifidobacterium longum subsp. infantis Species 0.000 description 1
- 208000035240 Disease Resistance Diseases 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- 244000199866 Lactobacillus casei Species 0.000 description 1
- 235000013958 Lactobacillus casei Nutrition 0.000 description 1
- 241000194020 Streptococcus thermophilus Species 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000181 anti-adherent effect Effects 0.000 description 1
- 229940002008 bifidobacterium bifidum Drugs 0.000 description 1
- 229940004120 bifidobacterium infantis Drugs 0.000 description 1
- 229940009291 bifidobacterium longum Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 208000028774 intestinal disease Diseases 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 229940017800 lactobacillus casei Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/005—Coating of tablets or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention relates to the technical field of preparation of probiotics, and discloses a composite probiotic preparation device and a preparation process thereof, wherein the composite probiotic preparation device comprises a coating box, and a container, a liquid spraying unit, a ph detection unit, a heating unit and a control unit are arranged in the coating box; a container for storing the composite probiotic tablet; the composite probiotic tablet comprises a tablet prepared from bacillus coagulans powder; the liquid spraying unit comprises a liquid A spray head and a liquid B spray head, wherein the liquid A spray head is used for spraying liquid A on the surface of the composite probiotic tablet; the solution A comprises a mixed aqueous solution of coating solution and phenol red, wherein the coating solution is prepared by mixing ethyl fibers with the aqueous solution; the input end of the liquid A spray head is communicated with the liquid A, and the output end of the liquid A spray head is correspondingly arranged with the composite probiotic tablets in the container; the composite probiotics prepared by the preparation process disclosed by the invention have the advantages of large number of living bacteria and small loss.
Description
Technical Field
The invention relates to the field of preparation of probiotics, in particular to a preparation device and a preparation process of composite probiotics.
Background
The compound probiotics are prepared by mixing a plurality of probiotics, wherein bacillus coagulans belongs to one type of beneficial bacteria, can regulate the balance of microbial flora in intestinal tracts, improve the immunity and disease resistance of organisms, reduce the occurrence of intestinal diseases, and has the optimum growth ph value of: 6.6-7.0.
The aqueous dispersion coating technology is to disperse the coating material in the form of nano-scale particles in water, then coat the probiotics, and the coating material is coated on the surface of the probiotics tablet, so that the probiotics can be ensured to enter the gastrointestinal environment of human body to be released at a constant rate, and the probiotics can be prevented from being directly contacted with the external environment to be deactivated.
The coating material is prepared by mixing ethyl cellulose and other auxiliary materials such as plasticizer, anti-adhesion agent and the like with an aqueous solution, however, when the surface of the composite probiotic tablet is coated, the coating liquid needs to be sprayed onto the surface of the composite probiotic tablet, then the coating liquid on the surface of the tablet is heated to evaporate water, the temperature rise can cause the concentration of hydroxyl in the ethyl cellulose aqueous solution on the surface of the probiotic tablet to increase, the alkalinity of the ethyl cellulose aqueous solution is further higher, the ph value is increased even to exceed 8, and for the bacillus coagulans component in the composite probiotic tablet, after the ph value is higher than 8, the growth of part of bacillus coagulans is inhibited or inactivated, so that the quantity of the bacillus coagulans in the finally prepared probiotic tablet is greatly reduced.
Disclosure of Invention
The invention provides a preparation device and a preparation process of composite probiotics, which solve the technical problem that in the related art, when a composite probiotic tablet is coated by an aqueous solution of ethyl cellulose, the pH value changes due to the temperature rise, and bacillus coagulans is inactivated.
The invention provides a composite probiotics preparation device which comprises a coating box, wherein a container, a liquid spraying unit, a ph detecting unit, a heating unit and a control unit are arranged in the coating box;
a container for storing the composite probiotic tablet;
the composite probiotic tablet comprises a tablet prepared from bacillus coagulans powder;
the liquid spraying unit comprises a liquid A spray head and a liquid B spray head, wherein the liquid A spray head is used for spraying liquid A on the surface of the composite probiotic tablet; the solution A comprises a mixed aqueous solution of coating solution and phenol red, wherein the coating solution is prepared by mixing ethyl fibers with the aqueous solution;
the input end of the liquid A spray head is communicated with the liquid A, and the output end of the liquid A spray head is correspondingly arranged with the composite probiotic tablets in the container;
a heating unit for evaporating the water of the liquid A sprayed on the surface of the composite probiotic tablet;
the ph detection unit is used for outputting a real-time ph value of the solution A on the surface of the composite probiotic tablet based on the color development reaction of the phenol red solution and the coating solution;
the liquid B spray head is used for spraying the liquid B onto the surface of the composite probiotic tablet to be combined with the liquid A, balancing the ph value of the liquid A, enabling the ph value of the liquid A to be in a ph safety range, communicating the input end of the liquid B spray head with the liquid B, and arranging the output end of the liquid B spray head corresponding to the composite probiotic tablet in the container; the solution B is ph regulator solution;
the ph safety range refers to a preset ph range for survival of bacillus coagulans;
and the control unit is used for controlling the liquid A spray head to spray the liquid A onto the composite probiotic tablet firstly and then controlling the liquid B spray head to spray the liquid B based on the real-time ph value monitoring result output by the ph detection unit until the real-time ph value monitoring result output by the ph detection unit of the liquid A is within a safe ph value range.
In a preferred embodiment, the container comprises a tablet plate, wherein a plurality of placing grooves matched with the composite probiotic tablets are formed in the tablet plate, a first hole penetrates through the center of each placing groove, and when the composite probiotic tablets are placed in the placing grooves, the surfaces of the composite probiotic tablets are exposed out of the placing grooves.
In a preferred embodiment, a biaxial driving unit is mounted on the suitcase, the biaxial driving unit comprises a Y-axis driving mechanism, a first mounting plate is mounted at the output end of the Y-axis driving mechanism, an X-axis driving mechanism is mounted on the first mounting plate, a second mounting plate is mounted at the output end of the X-axis driving mechanism, a connecting frame is mounted on the second mounting plate, and the liquid spraying unit is mounted on the connecting frame.
In a preferred embodiment, the Y-axis driving mechanism comprises a first frame, a first motor is mounted on the first frame, the output end of the first motor is connected with a first screw rod, a first sliding table which moves in a reciprocating mode along the axial direction of the first screw rod is mounted on the shaft of the first screw rod, and a first mounting plate is mounted on the first sliding table.
In a preferred embodiment, the X-axis driving mechanism comprises a second frame, a second motor is mounted on the second frame, the output end of the second motor is connected with a second screw rod, and a second sliding table which reciprocates along the second screw rod in the axial direction is mounted on the shaft of the second screw rod.
In a preferred embodiment, the jacking turnover mechanism for turning over the composite probiotics is arranged in the coating box, the jacking turnover mechanism comprises a top plate, a reset piece is arranged on the top plate, one end of the reset piece is fixedly connected with the coating box, a top rod is arranged on the top plate, a second hole which is eccentrically arranged is penetrated in the placing groove, the top rod is correspondingly arranged with the second hole, a cam driving mechanism is arranged in the coating box, the output end of the cam driving mechanism is connected with the top plate, and the cam driving mechanism is used for driving the top plate to vertically reciprocate.
In a preferred embodiment, the top side of the suitcase is provided with a feeding machine, the bottom side of the suitcase is provided with a discharging pipe, the side of the suitcase away from the heating unit is provided with a convection tube, and the bottom of the suitcase is provided with a supporting frame.
In a preferred embodiment, the coating box is provided with a turnover mechanism for turnover of the tablet board to pour the composite probiotic tablet, the turnover mechanism comprises a motor III, the output end of the motor III is connected with a speed reducer, and the output end of the speed reducer is connected with the tablet board.
In a preferred embodiment, the dual-shaft driving unit further comprises a first drag chain and a second drag chain, wherein two ends of the first drag chain are respectively connected with the Y-axis driving mechanism and the X-axis driving mechanism, and two ends of the second drag chain are respectively connected with the Y-axis driving mechanism and the X-axis driving mechanism.
A process for preparing composite probiotics, comprising the following steps:
s1, mixing and grinding bacillus coagulans powder and other probiotics powder to prepare tablets;
s2, spraying the solution A onto the surface of the composite probiotic tablet through a solution A spray head, and starting a heating unit to evaporate the water of the solution A;
s3, a ph detection unit of a ph detection unit monitors the ph value of the liquid A on the surface of the composite probiotic tablet in real time;
s4, based on the ph value of the liquid A obtained by monitoring of the ph detection unit, controlling the liquid B nozzle to spray the liquid B to the surface of the composite probiotic tablet to be mixed with the liquid A, and regulating the ph of the liquid A in the water evaporation process, so that the ph is always within a ph safety range.
The invention has the beneficial effects that:
the surface of the composite probiotic tablet is coated with a layer of ethylcellulose coating film, so that the composite probiotic tablet can avoid direct contact with the outside when entering the gastrointestinal part of a human body, is less sensitive to temperature and moisture in air, and therefore, living bacteria can be maintained for a long time without attenuation, and the composite probiotic tablet can be stored for a long time at normal temperature, cannot be deactivated after entering the human body, and can play an ideal curative effect.
The composite probiotics prepared by the preparation process disclosed by the invention have the advantages of large number of living bacteria and small loss.
Drawings
FIG. 1 is a schematic view showing the external structure of a production apparatus of the present invention.
FIG. 2 is a schematic diagram showing the front view of the production apparatus of the present invention.
Fig. 3 is a schematic diagram showing the configuration of the cooperation of the biaxial drive unit and the liquid ejecting unit of the present invention.
Fig. 4 is a schematic perspective view of a biaxial driving unit according to the present invention.
Fig. 5 is a schematic structural view of a tablet plate of the present invention.
Fig. 6 is an enlarged schematic view of the structure of fig. 2 a in accordance with the present invention.
Fig. 7 is a schematic diagram of the structure of the M-M view of fig. 3 according to the present invention.
Fig. 8 is a schematic diagram of the structure of the present invention at the N-N view angle in fig. 3.
Fig. 9 is a flow chart of the preparation process of the present invention.
In the figure: 1. a coat box; 11. a feeding machine; 12. discharging pipes; 13. a convection tube; 14. a support frame; 2. a tablet plate; 21. a placement groove; 22. a first hole; 23. a second hole; 3. a liquid spraying unit; 31. a, a liquid spray nozzle; 32. a liquid B spray head; 4. a biaxial driving unit; 41. a Y-axis driving mechanism; 411. a first frame; 412. a first motor; 413. a first screw rod; 414. a sliding table I; 42. an X-axis driving mechanism; 421. a second frame; 422. a second motor; 423. a second screw rod; 424. a sliding table II; 43. a first mounting plate; 44. a second mounting plate; 441. a connecting frame; 45. a drag chain I; 46. a drag chain II; 5. a ph detection unit; 6. a heating unit; 7. a jacking turn-over mechanism; 71. a top plate; 72. a reset member; 73. a push rod; 74. a cam driving mechanism; 8. a turnover mechanism; 81. a third motor; 82. a speed reducer.
Detailed Description
The subject matter described herein will now be discussed with reference to example embodiments. It is to be understood that these embodiments are merely discussed so that those skilled in the art may better understand and implement the subject matter described herein and that changes may be made in the function and arrangement of the elements discussed without departing from the scope of the disclosure herein. Various examples may omit, replace, or add various procedures or components as desired. In addition, features described with respect to some examples may be combined in other examples as well.
As shown in fig. 1-8, a composite probiotic preparation device comprises a coating box 1, wherein a container, a liquid spraying unit 3, a ph detecting unit 5, a heating unit 6 and a control unit are arranged in the coating box 1;
a container for storing the composite probiotic tablet;
the composite probiotic tablet comprises a tablet prepared from bacillus coagulans powder;
the liquid spraying unit 3 comprises a liquid A spray head 31 and a liquid B spray head 32, wherein the liquid A spray head 31 is used for spraying liquid A on the surface of the composite probiotic tablet; the solution A comprises a mixed aqueous solution of coating solution and phenol red, wherein the coating solution is prepared by mixing ethyl fibers with the aqueous solution;
the input end of the liquid A spray head 31 is communicated with the liquid A, and the output end of the liquid A spray head 31 is correspondingly arranged with the composite probiotic tablets in the container;
a heating unit 6 for evaporating the moisture of the liquid a sprayed onto the surface of the composite probiotic tablet;
the ph detection unit 5 outputs a real-time ph value of the solution A on the surface of the composite probiotic tablet based on the color development reaction of the phenol red solution and the coating solution;
the liquid B spray head 32 is used for spraying the liquid B onto the surface of the composite probiotic tablet to combine with the liquid A, balancing the ph value of the liquid A, enabling the ph value of the liquid A to be in a ph safety range, communicating the input end of the liquid B spray head 32 with the liquid B, and arranging the output end of the liquid B spray head 32 corresponding to the composite probiotic tablet in the container; the solution B is ph regulator solution;
the ph safety range refers to a preset ph range for survival of bacillus coagulans;
and the control unit controls the liquid A spray head 31 to spray the liquid A onto the composite probiotic tablet, and then controls the liquid B spray head 32 to spray the liquid B based on the real-time ph monitoring result output by the ph detection unit 5 until the real-time ph monitoring result of the liquid A output by the ph detection unit 5 is within a safe ph range.
It should be noted that, the inside of the coating box 1 is a sterile environment; the compound probiotic tablet comprises a tablet prepared by mixing Bacillus coagulans powder and other probiotic powder (such as any one or more of Bifidobacterium bifidum, bifidobacterium infantis, bifidobacterium longum, bifidobacterium breve, bifidobacterium adolescentis, lactobacillus acidophilus, lactobacillus casei, and Streptococcus thermophilus); the solution A comprises 20% of mixed aqueous solution of ethyl fiber, plasticizer, anti-adhesive and phenol red, and the solution B comprises ph regulator solution (for example, metal salt solution of a series of adjustable weak base solutions such as calcium carbonate solution, sodium carbonate solution and the like, and only needs to ensure that the metal salt solution does not influence the film formation of probiotics and coating solution); the ph safety range refers to a preset ph range (ph is 6.8 in the environment) which is most suitable for the survival of bacillus coagulans; the heating unit 6 is a hot air blower.
It should be further noted that, the ph detection unit 5 includes a non-contact sensor, by using the principle that the color development of the phenol red solution in different ph environments is different, the color change color level of the solution after the coating solution with different ph values reacts with the phenol red solution is set, and then the ph value corresponding to the color level of different colors is defined according to the color level of the solution with different ph values, as a calibration, the color calibration is input into the processing system, and the colorimetric procedure is edited; based on the color information of the A liquid on the surface of the composite probiotic tablet monitored by the non-contact sensor, transmitting the information to a processing system; and then carrying out color analysis and comparison based on the color change image information of the liquid A and calibration made in advance to obtain a colorimetric result, outputting a ph value, and controlling the liquid B spray head 32 to spray the liquid B based on the value to neutralize the liquid A and balance the ph environment.
In this embodiment, the implementation scenario specifically includes: placing the composite probiotic tablet with bacillus coagulans on a container, spraying liquid A on the surface of the composite probiotic tablet through a liquid A spray head 31, then starting a heating unit 6, evaporating water in the liquid A, and controlling a liquid B spray head 32 to spray liquid B on the surface of the composite probiotic tablet when a ph detection unit 5 monitors that the ph value of the liquid A is increased until a ph detection result of the liquid A output by the ph detection unit 5 is within a safe ph value range.
In an embodiment of the present invention, the ph detecting unit 5 may also use a non-contact photoelectric ph detecting method and a sensor used in the method of chinese patent document, application No. CN200810100909.9 to perform non-contact real-time monitoring of ph of the liquid a.
In one embodiment of the invention, the container comprises a tablet plate 2, a plurality of placing grooves 21 matched with the composite probiotic tablets are formed on the tablet plate 2, a first hole 22 is formed in the center of the placing groove 21, and when the composite probiotic tablets are placed in the placing groove 21, the surfaces of the composite probiotic tablets are exposed from the placing groove 21.
In one embodiment of the present invention, the two-axis driving unit 4 is mounted on the suitcase 1, the two-axis driving unit 4 includes a Y-axis driving mechanism 41, a first mounting plate 43 is mounted on an output end of the Y-axis driving mechanism 41, an X-axis driving mechanism 42 is mounted on the first mounting plate 43, a second mounting plate 44 is mounted on an output end of the X-axis driving mechanism 42, a connecting frame 441 is mounted on the second mounting plate 44, and the liquid spraying unit 3 is mounted on the connecting frame 441.
It should be noted that, the biaxial driving unit 4 drives the liquid spraying unit 3 to move on the X and Y axes, so that the speed of spraying the liquid a and the liquid B and the degree of adhesion of the liquid a and the liquid B on the surface of the composite probiotic tablet can be automatically adjusted based on the drying speed and the specific conditions.
In one embodiment of the present invention, the Y-axis driving mechanism 41 includes a first frame 411, a first motor 412 is mounted on the first frame 411, an output end of the first motor 412 is connected to a first screw 413, a first sliding table 414 that reciprocates along an axial direction of the first screw 413 is mounted on a shaft of the first screw 413, and the first mounting plate 43 is mounted on the first sliding table 414.
In one embodiment of the present invention, the X-axis driving mechanism 42 includes a second frame 421, a second motor 422 is mounted on the second frame 421, an output end of the second motor 422 is connected to a second screw 423, and a second sliding table 424 that reciprocates axially along the second screw 423 is mounted on an axis of the second screw 423.
In one embodiment of the invention, a jacking turnover mechanism 7 for turning over the composite probiotics is arranged in the coating box 1, the jacking turnover mechanism 7 comprises a top plate 71, a reset piece 72 is arranged on the top plate 71, one end of the reset piece 72 is fixedly connected with the coating box 1, a top rod 73 is arranged on the top plate 71, a second hole 23 eccentrically arranged is penetrated in the placing groove 21, the top rod 73 is arranged corresponding to the second hole 23, a cam driving mechanism 74 is arranged in the coating box 1, the output end of the cam driving mechanism 74 is connected with the top plate 71, and the cam driving mechanism 74 is used for driving the top plate 71 to vertically reciprocate.
In this embodiment, the implementation scenario specifically includes: after coating is completed on one side surface of the composite probiotic tablet, the cam driving mechanism 74 drives the top plate 71 and the top rod 73 to move upwards, the eccentric top moves the composite probiotic tablet to drive the composite probiotic tablet to turn over 180 degrees, and the composite probiotic tablet is pushed into the adjacent placing groove 21 from the placing groove 21 (as shown in fig. 5), so that coating on the other side of the tablet is facilitated.
In one embodiment of the invention, the top side of the coating tank 1 is provided with a feeding machine 11, the bottom side of the coating tank 1 is provided with a discharging pipe 12, the side of the coating tank 1 away from the heating unit 6 is provided with a convection pipe 13, and the bottom of the coating tank 1 is provided with a supporting frame 14.
The turnover mechanism 8 for turnover the tablet plate 2 to pour the composite probiotic tablet is arranged on the packing box 1, the turnover mechanism 8 comprises a motor III 81, the output end of the motor III 81 is connected with a speed reducer 82, and the output end of the speed reducer 82 is connected with the tablet plate 2.
The dual-shaft driving unit 4 further comprises a first drag chain 45 and a second drag chain 46, wherein two ends of the first drag chain 45 are respectively connected with the Y-axis driving mechanism 41 and the X-axis driving mechanism 42, and two ends of the second drag chain 46 are respectively connected with the Y-axis driving mechanism 41 and the X-axis driving mechanism 42.
In this embodiment, the implementation scenario specifically includes: when the coating of the two side surfaces of the composite probiotic tablet is completed, the turnover mechanism 8 drives the tablet plate 2 to rotate by taking the output shaft of the speed reducer 82 as an axis, and the composite probiotic tablet on the tablet plate 2 is turned over and poured into the blanking pipe 12.
As shown in fig. 9, a preparation process of the composite probiotics comprises the following steps:
s1, mixing and grinding bacillus coagulans powder and other probiotics powder to prepare tablets;
s2, spraying the solution A onto the surface of the composite probiotic tablet through a solution A spray head 31, and starting a heating unit 6 to evaporate the water of the solution A;
s3, a ph detection unit 5 monitors the ph value of the A liquid on the surface of the composite probiotic tablet in real time;
and S4, based on the ph value of the liquid A obtained by monitoring by the ph detection unit 5, controlling the liquid B spray head 32 to spray the liquid B to the surface of the composite probiotic tablet to be mixed with the liquid A, and regulating the ph value of the liquid A in the water evaporation process, so that the ph value is always within the ph value safety range.
The embodiment has been described above with reference to the embodiment, but the embodiment is not limited to the above-described specific implementation, which is only illustrative and not restrictive, and many forms can be made by those of ordinary skill in the art, given the benefit of this disclosure, are within the scope of this embodiment.
Claims (9)
1. The preparation device of the composite probiotics is characterized by comprising a coating box (1), wherein a container, a liquid spraying unit (3), a ph detecting unit (5), a heating unit (6) and a control unit are arranged in the coating box (1);
a container for storing the composite probiotic tablet;
the composite probiotic tablet comprises a tablet prepared from bacillus coagulans powder;
the liquid spraying unit (3) comprises a liquid A spray head (31) and a liquid B spray head (32), wherein the liquid A spray head (31) is used for spraying liquid A on the surface of the composite probiotic tablet; the solution A comprises a mixed aqueous solution of coating solution and phenol red, wherein the coating solution is prepared by mixing ethyl fibers with the aqueous solution;
the input end of the liquid A spray head (31) is communicated with the liquid A, and the output end of the liquid A spray head (31) is correspondingly arranged with the composite probiotic tablets in the container;
a heating unit (6) for evaporating the water of the liquid A sprayed onto the surface of the composite probiotic tablet;
the ph detection unit (5) outputs a real-time ph value of the solution A on the surface of the composite probiotic tablet based on the color development reaction of the phenol red solution and the coating solution;
the liquid B spray head (32) is used for spraying liquid B onto the surface of the composite probiotic tablet to be combined with liquid A, balancing the ph value of the liquid A, enabling the ph value of the liquid A to be in a ph safety range, the input end of the liquid B spray head (32) is communicated with the liquid B, and the output end of the liquid B spray head (32) is correspondingly arranged with the composite probiotic tablet in the container; the solution B is ph regulator solution;
the ph safety range refers to a preset ph range for survival of bacillus coagulans;
the control unit is used for controlling the liquid A spray head (31) to spray the liquid A onto the composite probiotic tablet firstly, and then controlling the liquid B spray head (32) to spray the liquid B based on the real-time ph value monitoring result output by the ph detection unit (5) until the real-time ph value monitoring result output by the ph detection unit (5) is in a safe ph value range;
the container comprises a tablet plate (2), a plurality of placing grooves (21) matched with the composite probiotic tablets are formed in the tablet plate (2), a first hole (22) is formed in the center of the placing groove (21) in a penetrating mode, and when the composite probiotic tablets are placed in the placing groove (21), the surfaces of the composite probiotic tablets are exposed out of the placing groove (21).
2. The composite probiotic preparation device according to claim 1, characterized in that the coating box (1) is provided with a double-shaft driving unit (4), the double-shaft driving unit (4) comprises a Y-shaft driving mechanism (41), an output end of the Y-shaft driving mechanism (41) is provided with a first mounting plate (43), an X-shaft driving mechanism (42) is provided with a first mounting plate (43), an output end of the X-shaft driving mechanism (42) is provided with a second mounting plate (44), a connecting frame (441) is provided with a second mounting plate (44), and the liquid spraying unit (3) is provided with a connecting frame (441).
3. The device for preparing composite probiotics according to claim 2, characterized in that the Y-axis driving mechanism (41) comprises a first frame (411), a first motor (412) is mounted on the first frame (411), an output end of the first motor (412) is connected with a first screw rod (413), a first sliding table (414) which moves axially and reciprocally along the first screw rod (413) is mounted on an axis of the first screw rod (413), and the first mounting plate (43) is mounted on the first sliding table (414).
4. A compound probiotic preparation device according to claim 3, wherein the X-axis driving mechanism (42) comprises a second frame (421), a second motor (422) is mounted on the second frame (421), an output end of the second motor (422) is connected with a second screw rod (423), and a second sliding table (424) which axially reciprocates along the second screw rod (423) is mounted on an axis of the second screw rod (423).
5. The composite probiotic preparation device according to claim 4, wherein a jacking turnover mechanism (7) for turning over the composite probiotics is arranged in the coating box (1), the jacking turnover mechanism (7) comprises a top plate (71), a reset piece (72) is arranged on the top plate (71), one end of the reset piece (72) is fixedly connected with the coating box (1), a top rod (73) is arranged on the top plate (71), a second hole (23) eccentrically arranged is penetrated in the placing groove (21), the top rod (73) is correspondingly arranged with the second hole (23), a cam driving mechanism (74) is arranged in the coating box (1), and the output end of the cam driving mechanism (74) is connected with the top plate (71), and the cam driving mechanism (74) is used for driving the top plate (71) to vertically reciprocate.
6. The composite probiotic preparation device according to claim 5, characterized in that a feeding machine (11) is installed on one side of the top of the coating box (1), a discharging pipe (12) is installed on one side of the bottom of the coating box (1), a convection pipe (13) is installed on one side of the coating box (1) far away from the heating unit (6), and a supporting frame (14) is installed on the bottom of the coating box (1).
7. The composite probiotic preparation device according to claim 6, characterized in that a turnover mechanism (8) for overturning the tablet plate (2) to pour the composite probiotic tablet is mounted on the coating box (1), the turnover mechanism (8) comprises a motor III (81), the output end of the motor III (81) is connected with a speed reducer (82), and the output end of the speed reducer (82) is connected with the tablet plate (2).
8. The composite probiotic preparation device according to claim 7, wherein the dual-shaft driving unit (4) further comprises a first drag chain (45) and a second drag chain (46), two ends of the first drag chain (45) are respectively connected with the Y-axis driving mechanism (41) and the X-axis driving mechanism (42), and two ends of the second drag chain (46) are also respectively connected with the Y-axis driving mechanism (41) and the X-axis driving mechanism (42).
9. The process for preparing a composite probiotic preparation device according to any one of claims 1 to 8, comprising the steps of:
s1, mixing and grinding bacillus coagulans powder and other probiotics powder to prepare tablets;
s2, spraying the solution A onto the surface of the composite probiotic tablet through a solution A spray head (31), and starting a heating unit (6) to evaporate the water of the solution A;
s3, a ph detection unit (5) monitors the ph value of the solution A on the surface of the composite probiotic tablet in real time;
s4, based on the ph value of the liquid A obtained by monitoring of the ph detection unit (5), controlling the liquid B nozzle (32) to spray the liquid B to the surface of the composite probiotic tablet to be mixed with the liquid A, and regulating the ph value of the liquid A in the water evaporation process, wherein the ph value is always within the ph safety range.
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| CN116421468A (en) | 2023-07-14 |
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