CN116407264A

CN116407264A - Catheter, catheter assembly and plugging ablation system

Info

Publication number: CN116407264A
Application number: CN202111678372.6A
Authority: CN
Inventors: 吴能标; 王坤; 李建民
Original assignee: Hangzhou Dinova EP Technology Co Ltd
Current assignee: Hangzhou Dinova EP Technology Co Ltd
Priority date: 2021-12-31
Filing date: 2021-12-31
Publication date: 2023-07-11
Also published as: WO2023125268A1

Abstract

The invention provides a catheter, a catheter assembly and a plugging ablation system. The catheter is used for implanting the plugging ablation device into a patient and comprises a connector, a tube body and a conductor; the far end of the connector is detachably connected with the plugging ablation device; the proximal end of the connector is connected with the pipe body, the distal end of the connector is detachably connected with the plugging ablation device, the plugging device is moved to a preset position in a patient through the pipe body and the connector, and after plugging is realized, the connector is operated to be separated from the plugging ablation device, and the plugging ablation device is injected into the patient. The electric conductor is electrically connected with the connector and is used for providing electric energy for the plugging ablation device so as to be used for ablation. The electric connector is beneficial to reducing the influence of the connection of the electric conductor on the connector on the inner diameter and the outer diameter of the connector, so that electric energy is provided for the connector on the basis that the wall thickness of the conduit is not increased or the degree of increase is small.

Description

Catheter, catheter assembly and plugging ablation system

Technical Field

The invention relates to the technical field of medical instruments, in particular to a catheter, a catheter assembly and a plugging ablation system.

Background

Atrial fibrillation (abbreviated as atrial fibrillation) is the most common sustained arrhythmia. The incidence of atrial fibrillation increases with age, and the incidence of atrial fibrillation can reach 10% for people over 75 years old. When the atria are in atrial fibrillation, the atrial activation frequency reaches 300-600 times/minute, the heartbeat frequency is often rapid and irregular, and the atria lose effective contractile function. The left auricle contraction force is reduced during atrial fibrillation, and the morphological characteristics of the left auricle and the small muscle Liang Tuao in the left auricle are uneven, so that the blood flow in the left auricle generates vortex and the flow velocity is reduced, and thrombosis is promoted. More than Fang Xieshuan% of patients with non-valvular ward fibrillation are present in the left atrial appendage. Cerebral embolism, i.e. cerebral apoplexy, can be formed by entering cerebral arterial vessels through aortic vessels after thrombus is shed.

Some atrial fibrillation patients may benefit from active left atrial appendage electrical isolation (left atrial appendage isolation, LAAI). The left auricle is electrically isolated and mostly adopts ablation treatment, and the ablation treatment comprises various aspects: in one aspect, thermal ablation such as radio frequency ablation, laser ablation, microwave ablation, thermal mass ablation, etc., and in addition, pulse ablation utilizing the principle of bioelectroporation.

The left atrial appendage electrical isolation can be achieved on a left atrial appendage occluder, that is, an ablation component for electrical ablation is added on the left atrial appendage occluder to form a left atrial appendage occlusion ablation device, the ablation component needs to be electrically connected with a delivery catheter of the left atrial appendage occlusion ablation device, and an electrical conductor and a connecting piece, such as a wire and a connector, which are electrically connected with the ablation component need to be added in the delivery catheter, so that the wall thickness of the delivery catheter is increased.

However, the wall thickness of the delivery catheter is limited by various factors, on one hand, the outer diameter of the delivery catheter is limited by the left atrial appendage occlusion device and the puncture incision, and on the other hand, the inner diameter of the channel of the delivery catheter needs to meet the requirement that instruments such as a mapping catheter and a guiding guide wire can pass through, so that the design difficulty of the delivery catheter matched with the left atrial appendage occlusion ablation device is high.

Disclosure of Invention

The invention aims to provide a catheter which is used for supplying electric energy to the catheter without increasing the outer diameter of the catheter.

In order to solve the technical problems, the invention adopts the following technical scheme:

according to one aspect of the present invention, there is provided a catheter for implanting a plugged ablation device in a patient, comprising a connector, a tube, and an electrical conductor; the distal end of the connector is detachably connected with the plugging ablation device; when the connector is connected with the plugging ablation device, the connector is electrically connected with the plugging ablation device; the proximal end of the connector is provided with an extension channel; the distal end of the tube body is fixedly arranged at the proximal end of the connector; the electric conductor extends along the axial direction of the pipe body; the far end of the electric conductor penetrates through the extension channel and is electrically connected with the connector for conveying electric energy to the connector.

According to another aspect of the present invention, there is provided a catheter assembly comprising a first catheter and a second catheter, both of which are the above-mentioned catheters; the second catheter is wrapped on the periphery of the first catheter, and the distal end of the first catheter can exceed the distal end of the second catheter.

According to another aspect of the present invention, there is provided an occlusion ablation system comprising an occlusion ablation device and at least one catheter as described above; the plugging ablation device is used for plugging tissue defects and can ablate the tissues by utilizing electric energy; the plugging ablation device is detachably connected to the far end of the connector, and the catheter is used for conveying and releasing the plugging ablation device to a tissue defect position and can transmit ablation electric energy to the plugging ablation device.

According to the technical scheme, the invention has at least the following advantages and positive effects:

according to the invention, the proximal end of the connector is connected with the tube body, the distal end of the connector is detachably connected with the plugging ablation device, and the plugging device is conveyed to a preset position in a patient body through the tube body and the connector for release, so that the tissue defect can be plugged. The electric conductor is electrically connected with the connector and is used for providing electric energy for the plugging ablation device so as to be used for ablation.

The conductor is worn to establish in the extension passageway of connector, is favorable to reducing the conductor and leads to the fact the influence to the internal diameter and the external diameter of connector at the connection epaxial connection to on the basis that catheter wall thickness does not increase, or the degree of increase is less, provide the electric energy for the connector.

The catheter assembly comprises a first catheter and a second catheter, wherein the first catheter and the second catheter are respectively provided with a connector, and the two connectors can respectively supply power for the plugging ablation device so as to transmit the same or different ablation electric energy to the plugging ablation device.

Drawings

Fig. 1 is a schematic view of the structure of a first embodiment of the catheter of the present invention.

Fig. 2 is a schematic structural view of a connector according to a first embodiment of the catheter of the present invention.

Fig. 3 is a schematic view showing a part of the structure of a first embodiment of the catheter of the present invention, in which the catheter body is cut in the radial direction.

Fig. 4 is a schematic view showing a part of the structure of a second embodiment of the catheter of the present invention, in which the catheter body is cut in the radial direction.

Fig. 5 is a schematic structural view of a connector according to a second embodiment of the catheter of the present invention.

Fig. 6 is a schematic view showing a part of the structure of a third embodiment of the catheter of the present invention, in which the catheter body is cut in the radial direction.

Fig. 7 is a schematic structural view of a connector according to a third embodiment of the catheter of the present invention.

Fig. 8 is a schematic view of a portion of a connector according to a fourth embodiment of the catheter of the present invention, wherein the catheter body is radially cut.

Fig. 9 is a schematic cross-sectional view of a fifth embodiment of the catheter of the invention.

Fig. 10 is a schematic view showing a part of the construction of a fifth embodiment of the catheter of the present invention.

Fig. 11 is a schematic cross-sectional view of a sixth embodiment of the catheter of the invention.

Fig. 12 is a schematic cross-sectional view of a seventh embodiment of the catheter of the invention.

Fig. 13 is a schematic cross-sectional view of an eighth embodiment of the catheter of the present invention.

Fig. 14 is a schematic view of the structure of an embodiment of a catheter assembly of the present invention.

Fig. 15 is a schematic view of a structure of an occluding ablation device.

Fig. 16 is a schematic cross-sectional view of another embodiment of a catheter assembly of the present invention.

Fig. 17 is a schematic view of a connector according to the present invention.

The reference numerals are explained as follows: 10. a first conduit; 20. a second conduit; 100. a connector; 110. an inner cavity; 120. an extension channel; 130. a connection part; 140. a plug-in part; 150. a step; 160. a hollowed-out window; 170. a fixing groove; 180. a pressing member; 190. a ring bulge; 200. a tube body; 201. an outer layer; 202. an extension tube; 210. an inner layer; 220. an outer layer; 230. a woven mesh; 240. a PTFE layer; 250. an inner wall; 260. an outer wall; 280. an insulating layer; 290. a lumen; 300. an electric conductor; 310. an insulating sleeve; 400. a connector; 420. an extension channel; 430. a connection part; 440. a plug-in part; 441. a spring plate; 442. a plug section; 50. plugging the ablation device; 510. a sealing part; 520. an anchor portion; 530. a connecting piece; 540. a first ablating member; 550. a second ablating member; 560. a first conductor; 570. and a second conductor.

Detailed Description

Exemplary embodiments that embody features and advantages of the present invention will be described in detail in the following description. It will be understood that the invention is capable of various modifications in various embodiments, all without departing from the scope of the invention, and that the description and illustrations herein are intended to be by way of illustration only and not to be construed as limiting the invention.

In the description of the present application, it should be understood that the terms "center," "longitudinal," "transverse," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," etc. indicate or are based on the orientation or positional relationship shown in the drawings, merely for convenience of description and to simplify the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present application. Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more of the described features. In the description of the present application, the meaning of "a plurality" is two or more, unless explicitly defined otherwise.

For ease of description and understanding, in the field of interventional medical devices, the end of the medical device implanted in the human or animal body that is closer to the operator is generally referred to as the "proximal end", the end that is farther from the operator is referred to as the "distal end", and the "proximal end" and "distal end" of any component of the medical device are defined in accordance with this principle. The position of the left atrium entering the left auricle is defined as the mouth of the left auricle, and the position of the left auricle adjacent to the left auricle mouth is defined as the neck of the left auricle. "axial" generally refers to the longitudinal direction of a medical device when delivered, and "radial" generally refers to the direction of the medical device perpendicular to its "axial" direction, and defines the "axial" and "radial" directions of any component of the medical device in accordance with this principle.

The application provides a plugging ablation system, which comprises a catheter and a plugging ablation device; the occluding ablation device is attached to and detachable from the distal end of the catheter. The catheter is used for conveying and releasing the plugging ablation device to the tissue defect and can transmit ablation electric energy to the plugging ablation device. The plugging ablation device is used for plugging tissue defects and can ablate the tissues by utilizing electric energy; the plugging ablation device is detachably connected to the distal end of the connector.

When the occlusion is performed, the catheter moves to the far end, the occlusion ablation device is driven to be conveyed to the left auricle, the occlusion ablation device is released and unfolded in the left heart, and the mouth of the left auricle is occluded. The catheter provides ablation electric energy for the plugging ablation device, and the plugging ablation device can ablate the inner wall of the left auricle, so that plugging and ablation of the left auricle are completed. It can be understood that the embodiment of the invention is described by taking the plugging and ablating device as a left auricle plugging and ablating device as an example, namely, the plugging and ablating device is used for plugging the mouth of the left auricle, so that cerebral embolism is prevented from being formed by entering a cerebral arterial vessel through an aortic vessel after thrombus in the left auricle is shed. The plugging ablation device is also used for electrically ablating tissues, such as left atrial appendage tissues, so that the purpose of treating atrial fibrillation is achieved through left atrial appendage electrical isolation. The electrical ablation may be in the form of pulsed ablation, radiofrequency ablation, or microwave ablation, among others. It can be appreciated that the plugging ablation device in the embodiments of the present application may also be used for plugging and electrically ablating other tissues in a patient, and the specific plugging and ablating positions are not limited.

Fig. 1 is a schematic view of the structure of a first embodiment of the catheter of the present invention. Fig. 2 is a schematic structural view of a connector according to a first embodiment of the catheter of the present invention. Fig. 3 is a schematic view showing a part of the structure of a first embodiment of the catheter of the present invention, in which the catheter body is cut in the radial direction.

Referring to fig. 1 to 3, the present embodiment provides a catheter detachably connected to a plugging ablation device for delivering and releasing the plugging ablation device into a patient, and for delivering ablation power to the plugging ablation device, the plugging ablation device being for plugging a tissue defect and for ablating the tissue using the ablation power delivered via the catheter. The catheter comprises a connector 100 for connecting the plugging ablation device, a tube body 200 connected to one end of the connector 100 back to the plugging ablation device, and a conductor 300 penetrating through the tube body 200. The distal end of the electrical conductor 300 is electrically connected to the header 100. The distal end of connector 100 is removably attached to and electrically connected to the occluding ablation device. The distal end of the tube body 200 is fixedly disposed at the proximal end of the connector 100, and the tube body 200 extends in the axial direction.

A blocking ablation device is attached to the connector 100 and can be detached from the distal end of the connector 100. When the plugging is performed, the pushing tube 200 moves to the distal end, the connector 100 is driven to move to the distal end, the connector 100 conveys the plugging ablation device to the left auricle, the plugging ablation device is released and unfolded in the left auricle, and the mouth of the left auricle is plugged. The conductor 300 provides ablation electric energy to the plugging ablation device through the connector 100, and the plugging ablation device ablates the inner wall of the left auricle by using the ablation electric energy transmitted by the catheter, so that plugging and ablation of the left auricle are completed. After performing the occlusion ablation, the catheter and the occlusion ablation device are separated and withdrawn from the body. The catheter and the plugging ablation device can be used for realizing plugging and ablation simultaneously in one operation.

As shown in fig. 3, the connector 100 is provided with an inner cavity 110 that is penetrated in the axial direction, and the inner cavity 110 penetrates the proximal end and the distal end of the connector 100 in the axial direction. The tube body 200 is a tubular structure with a lumen 290 arranged inside, the inner cavity 110 of the connector 100 is communicated with the lumen 290 of the tube body 200, and the inner cavity 110 and the lumen 290 form a channel for a mapping catheter, a guiding guide wire and the like to pass through, so that the mapping catheter or the guiding guide wire can penetrate into the channel from the proximal end of the tube body 200 and extend to the distal end of the plugging ablation device.

The radial cross section of the coupling head 100 is circular, and the outer circumference of the tube body 200 is circular, so as to facilitate the movement of the coupling head 100 and the tube body 200 in the delivery sheath. To ensure that lumen 110 of connector 100 and lumen 290 of tube 200 have sufficient space in the radial direction for a mapping catheter, guide wire, etc. to pass through, and the outer diameter of outer diameter tube 200 of connector 100 is small enough to pass through a corresponding vessel or tissue, resulting in a limited wall thickness of the catheter in which connector 100 is disposed.

The proximal end of the connector 100 is provided with an extension channel 120, and the distal end of the electrical conductor 300 is disposed in the extension channel 120 in a penetrating manner and electrically connected to the connector 100 for supplying electrical energy to the connector 100. The proximal end of the connector 100 is provided with an extension channel 120 for the conductor 300 to connect and pass through, and through the penetration of the conductor 300 in the extension channel 120, the conductor 300 is fully or partially accommodated in the extension channel 120 along the radial direction of the conductor, so that the connector 100 is provided with electric energy on the basis that the wall thickness of the catheter is not increased or the degree of increase is small.

The connector 100 includes a connection portion 130 and a plug portion 140 protruding from a distal end of the connection portion 130; the connection portion 130 and the plug portion 140 extend in the axial direction; the plug portion 140 is configured to removably couple with the occluding ablation device. The pipe body 200 is connected to the connection part 130.

The extension channel 120 is formed at a proximal end of the connection portion 130, so that the electrical conductor 300 can be inserted through and electrically connected to the connection portion 130 from the proximal end.

In this embodiment, the connection portion 130 and the plug portion 140 are both tubular, the outer diameter of the connection portion 130 is larger than the outer diameter of the plug portion 140, and a step 150 is formed between the connection portion 130 and the plug portion 140. In some embodiments, the size between the outer diameter of the connection part 130 and the outer diameter of the socket part 140 is not limited, and a ring groove, which is circumferentially disposed around the axis of the coupling head 100 at the outer circumference of the coupling head 100 for fixing the distal end of the tube body 200, is formed between the connection part 130 and the socket part 140.

The connector 100 is made of conductive material, and the insertion portion 140 of the connector 100 extends into the plugging ablation device in the axial direction and is detachably connected to the plugging ablation device. In this embodiment, the outer periphery of the plugging portion 140 is provided with external threads for threaded connection of the plugging ablation device, and the plugging ablation device is detachably connected. It will be appreciated that in other embodiments, the removable connection of the hub 140 to the occluding ablation device is not limited to a threaded connection.

In this embodiment, the outer peripheral surface of the connecting portion 130 is provided with a guiding groove to form the extension channel 120. The guide groove is opened at the proximal end of the connection part 130. The distal end of the electrical conductor 300 is inserted into the extension channel 120 and connected to the extension channel 120 to electrically connect the connector 100. In other embodiments, the connecting portion 130 is provided with holes through its proximal and distal faces to form the extension channel 120.

In this embodiment, the guide groove is formed on the outer circumference of the connection portion 130 and extends in the axial direction. In some embodiments, the guide groove is formed on the outer circumference of the connection part 130, and the guide groove is shaped as an arc, a fold line, or a spiral line. In other embodiments, the guide groove is opened on the inner circumferential surface of the connection part 130.

In this embodiment, the extension channel 120 extends through the distal end of the connection 130, and in some embodiments, the distal end of the extension channel 120 does not extend through the distal end of the connection 130.

Referring again to fig. 1-3, the electrical conductor 300 extends along the axial direction of the tube 200, with the electrical conductor 300 being located within the tube 200. The distal end of the conductive body 300 is connected to the peripheral wall (e.g., the side wall or the bottom wall of the guide groove) of the extension channel 120 by welding, pasting, or heat-fusing, etc., to electrically connect the connector 100.

The conductor 300 is a wire, which is a metal wire or an enamel wire. The distal end of the lead is attached to the peripheral wall of the extension channel 120 by welding, adhesive, or the like. The position beyond the distal end of the wire can be mutually insulated from the connector, for example, an insulating layer is arranged on part of the surface beyond the distal end of the wire, and the insulating layer can be insulating paint, insulating sleeve or insulating sleeve is arranged outside the insulating paint. The distal end of the lead is electrically connected to the connector, so that the insulating layer at the distal end of the lead is peeled off, and the metal conductive portion is exposed to electrically connect to the connector. It will be appreciated that in some embodiments, the portion of the surface of the wire that contacts connector 100 is electrically conductive. Optionally, the portion of the wire where the insulation is provided is fixedly connected to the connector, such as by adhesive or hot melt connection.

The portion of the wire facing away from connector 100 is located within the tube diameter of tube 200 or within the wall thickness of the tube.

The diameter of the wire is smaller than the width of the extension channel 120 so that the extension channel 120 can accommodate the wire. In some embodiments, the depth of extension channel 120 in the radial direction is greater than the diameter of the wire to ensure that the distal end of the wire is received within extension channel 120 without extending radially outward of connector 100 beyond the outer perimeter of connector 100, thereby not increasing the thickness of the overlap of connector 100 and electrical conductor 300. In some embodiments, the extension channel 120 is an interference fit with the wire in the circumferential width direction to clamp the wire.

Referring again to fig. 1 to 3, the pipe body 200 includes an inner layer 210, and an outer layer 220 coated on the outer circumference of the inner layer 210; the distal end of the inner layer 210 extends into the inner cavity 110 of the connector 100 and is attached to the inner periphery of the connector 100; the outer layer 220 covers the outer circumference of the connection portion 130, and covers the connection portion 130 and a portion of the conductor 300 located at the connection head 100.

The connection portion 130 and the insertion portion 140 of the connector 100 are both tubular structures. The distal end of the inner layer 210 is disposed in the inner cavity 110 of the connector 100 in a penetrating manner, and the outer circumferential surface of the inner layer 210 abuts against the inner circumferential wall of the inner cavity 110 of the connector 100. The inner cavity 110 of the connector 100 is formed with a step surface between the connecting portion 130 and the inserting portion 140, the inner diameter of the connecting portion 130 is larger than the inner diameter of the inserting portion 140, the inner peripheral wall of the connecting portion 130 is sleeved on the outer periphery of the inner layer 210, and the inner cavity of the inserting portion 140 is communicated with the cavity of the inner layer 210.

The distal outer periphery of the inner layer 210 is attached to the inner periphery of the connection portion 130; the inner peripheral wall of the inner layer 210 is flush with the inner peripheral wall of the plug-in portion 140, so that no step exists on the surface of the inner wall of the catheter, threading of a guide wire or other catheters is facilitated, damage to the inner layer 210 is avoided in the process of internally threading the guide wire or catheters, falling of inner layer materials into a patient is avoided, and product safety is improved.

The outer layer 220 of the pipe body 200 is made of thermoplastic material, and the outer layer 220 is heat-fused and covers the connection portion 130 of the connector 100. The outer layer 220 covers the step 150 between the connection part 130 and the socket part 140 to effectively secure the reliability of the connection between the pipe body 200 and the coupling head 100.

The outer layer 220 of the tube body 200 is made of a plastic material such as PA, PEBAX, HDPE and nylon.

In this embodiment, the portion of the conductor 300 away from the joint 100 is located within the wall thickness of the pipe body 200. Specifically, the electrical conductor 300 is located between the inner layer 210 and the outer layer 220, and when the outer layer 220 covers the inner layer 210, a portion of the electrical conductor 300 away from the connection head 100 is covered between the inner layer 210 and the outer layer 220.

In some embodiments, the portion of electrical conductor 300 distal from connector 100 is located within lumen 290 of tube 200.

Fig. 4 is a schematic view showing a part of the structure of a second embodiment of the catheter of the present invention, in which the catheter body is cut in the radial direction. Fig. 5 is a schematic structural view of a connector according to a second embodiment of the catheter of the present invention.

Referring to fig. 4 and 5, in the present embodiment, the catheter includes a connector 100 for connecting to the plugging ablation device, a tube 200 connected to an end of the connector 100 opposite to the plugging ablation device, and an electrical conductor 300 penetrating the tube 200. The distal end of the electrical conductor 300 is electrically connected to the header 100. The distal end of connector 100 is removably attached to and electrically connected to the occluding ablation device. The distal end of the connector 100 is used for connecting with a plugging ablation device, the distal end of the tube body 200 is fixedly arranged at the proximal end of the connector 100, and the tube body 200 extends along the axial direction.

The connector 100 is provided with an inner cavity 110 which is penetrated along the axial direction, and the inner cavity 110 is penetrated along the axial direction through the proximal end and the distal end of the connector 100.

The proximal end of the connector 100 is provided with an extension channel 120, and the distal end of the electrical conductor 300 is disposed in the extension channel 120 in a penetrating manner and electrically connected to the connector 100 for supplying electrical energy to the connector 100.

The pipe body 200 comprises an inner layer 210 and an outer layer 220 coated on the outer periphery of the inner layer 210, wherein the distal end of the inner layer 210 extends into the connector 100 and is attached to the inner periphery of the connector 100; the outer layer 220 covers the outer circumference of the connection portion 130 and covers the portion of the conductor 300 located at the connection head 100.

The structures and connection relationships of the connector 100, the pipe 200, and the conductor 300 are referred to the structures of the connector 100, the pipe 200, and the conductor 300 in the first embodiment, and are not described herein.

The present embodiment differs from the first embodiment in that:

the connecting portion 130 has a hollow window 160 radially extending through the inner cavity 110. In this embodiment, the hollowed-out windows 160 are disposed in a plurality along the circumferential direction of the connecting portion 130 at intervals. In some embodiments, the hollowed-out window 160 is provided as a single piece. In other embodiments, the plurality of hollow windows 160 are disposed on the connecting portion 130 in a staggered manner.

When the outer layer 220 is heat-fused and covers the connecting portion 130, the outer layer 220 of the pipe body 200 passes through the hollow window 160 and is heat-fused and connected to the inner layer 210, so as to enhance the connection stability and reliability between the pipe body 200 and the connector 100.

In this embodiment, the outer diameter of the connection portion 130 is larger than the outer diameter of the socket portion 140, and a step surface 150 is formed between the connection portion 130 and the socket portion 140, and the step surface 150 is connected between the outer peripheral wall of the connection portion 130 and the outer peripheral wall of the socket portion 140. The distal end of the extension channel 120 penetrates the step surface 150, and the distal end of the electrical conductor 300 penetrates the extension channel 120 to be fixed (such as winding, welding, etc.) on the outer surface of the socket 140 or the step surface 150, so that the connection of the electrical conductor 300 is more stable.

The distal end of the tube 200 is coated with a wall thickness D at the location of the connection 130, and the wall thickness diameter D of the tube 200 at the location not connected to the connection 130 is less than 0.2mm. That is, the distance between the inner peripheral surface of the inner layer 210 and the outer periphery of the outer layer 220 is d at a position of the pipe body 200 distant from the joint 100; the distance between the inner circumferential surface of the inner layer 210 and the outer circumferential surface of the outer layer 220 at the portion of the pipe body 200 connected to the connection portion 130 is D.

Fig. 6 is a schematic view showing a part of the structure of a third embodiment of the catheter of the present invention, in which the catheter body is cut in the radial direction. Fig. 7 is a schematic structural view of a connector according to a third embodiment of the catheter of the present invention.

Referring to fig. 6 and 7, in the present embodiment, the catheter includes a connector 100 for connecting to the plugging ablation device, a tube 200 connected to an end of the connector 100 opposite to the plugging ablation device, and an electrical conductor 300 penetrating the tube 200. The distal end of the electrical conductor 300 is electrically connected to the header 100. The distal end of connector 100 is removably attached to and electrically connected to the occluding ablation device. The distal end of the connector 100 is used for connecting with a plugging ablation device, the distal end of the tube body 200 is fixedly arranged at the proximal end of the connector 100, and the tube body 200 extends along the axial direction.

The connector 100 is provided with an inner cavity 110 which is penetrated along the axial direction, and the inner cavity 110 is penetrated along the axial direction through the proximal end and the distal end of the connector 100. The proximal end of the connector 100 is provided with an extension channel 120, and the distal end of the electrical conductor 300 is disposed in the extension channel 120 in a penetrating manner and electrically connected to the connector 100 for supplying electrical energy to the connector 100. The connector 100 includes a connection portion 130 and a plug portion 140 protruding from a distal end of the connection portion 130; the connection portion 130 and the plug portion 140 extend in the axial direction; the plug portion 140 is configured to removably couple with the occluding ablation device. The pipe body 200 is connected to the connection part 130.

In this embodiment, the outer peripheral surface of the connecting portion 130 is provided with a guiding groove to form the extension channel 120. The guide groove is opened at the proximal end of the connection part 130, and penetrates the distal end of the connection part 130. The pipe body 200 comprises an inner layer 210 and an outer layer 220 coated on the outer periphery of the inner layer 210, wherein the distal end of the inner layer 210 extends into the connector 100 and is attached to the inner periphery of the connector 100; the outer layer 220 covers the outer circumference of the connection portion 130 and covers the portion of the conductor 300 located at the connection head 100.

The structures and connection relationships of the connector 100, the pipe 200, and the conductor 300 are referred to the structures of the connector 100, the pipe 200, and the conductor 300 in the second embodiment, and are not described herein.

The present embodiment differs from the second embodiment in that:

the connector 100 is provided with a fixing groove 170 at the distal end of the extension channel 120, and the extension direction of the fixing groove 170 is different from the extension direction of the extension channel 120; the distal end of the extension channel 120 communicates with the stationary slot 170.

In this embodiment, the outer diameter of the connection portion 130 is larger than the outer diameter of the insertion portion 140, a ring protrusion 190 is protruding from the outer periphery of the insertion portion 140 at the distal end of the connection portion 130, the ring protrusion 190 extends around the axial direction of the insertion portion 140, the ring protrusion 190 and the connection portion 130 are disposed at intervals along the axial direction, and a fixing groove 170 is formed between the ring protrusion 190 and the connection portion 130.

In the present embodiment, the fixing groove 170 is disposed on the outer circumferential surface of the connection part 130 around the axial line circumference of the connection part 130. In some embodiments, the securing slot 170 can be other than a circumferential ring-shaped structure, with the securing slot 170 being a helical structure.

The connecting portion 130 has a hollow window 160 extending radially therethrough to the cavity 110. In this embodiment, the hollowed-out windows 160 are disposed in a plurality along the circumferential direction of the connecting portion 130 at intervals.

Referring again to fig. 6 and 7, the electrical conductor 300 extends along the axial direction of the tube body 200, and the electrical conductor 300 is located within the tube body 200. The electrical conductor 300 is a wire and the distal end of the electrical conductor 300 extends out of the extension channel 120. The portion of the distal end of the electrical conductor 300 that passes out of the extension channel 120 is wound in the fixing groove 170.

The conducting wire is a metal wire. The metal part of the distal end of the wire is wound in the fixing groove 170, the surface of the wire wound in the fixing groove 170 is conductive, the insulating layer is disposed, the conductive contact area between the wire and the connector 100 is increased, and the stability of connection between the conductor 300 and the connector 100 is improved.

The depth of the fixing groove 170 in the radial direction is greater than the depth of the extension passage 120 in the radial direction so as to wind the wire in the fixing groove 170 in a plurality of turns to enhance the reliability and stability of the connection of the wire in the fixing groove 170. The depth of the fixed slot 170, and the depth of the extension channel 120, are the dimensions they each occupy in the radial direction. Specifically, in some embodiments, the fixing groove 170 is formed at the connection portion between the connection portion 130 and the plug portion 170, and the forming of the fixing groove 170 is not affected by the wall thickness of the connection portion 130, so that the fixing groove 170 can be set to a greater depth, i.e. the depth of the fixing groove 170 is greater than the thickness of the connection portion 130. In a specific embodiment, the fixing groove 170 extends radially toward the inner circumference of the socket part 140 and penetrates to the socket part 140.

The width of the fixing groove 170 is adapted to the diameter of the wire so as to press the wire between the two side walls of the fixing groove 170, the wire is wound in the fixing groove 170, and other fixing methods are not needed to fix the wire and the connector 100. In the present embodiment, the fixing groove 170 is circumferentially arranged in a direction perpendicular to the axial direction of the joint head 100, and the width of the fixing groove 170 is the dimension that it occupies in the axial direction.

The diameter of the wire is smaller than the width of the extension channel 120 so that the extension channel 120 can accommodate the wire. In some embodiments, the depth of extension channel 120 in the radial direction is greater than the diameter of the wire to ensure that the portion of the wire within extension channel 120 is received within extension channel 120 without facing radially outward of connector 100 toward the outer perimeter of connector 100, thereby not increasing the thickness where connector 100 and electrical conductor 300 overlap.

Referring to fig. 8, in this embodiment, the catheter includes a connector 100 for connecting to the plugging ablation device, a tube 200 connected to an end of the connector 100 opposite to the plugging ablation device, and an electrical conductor 300 penetrating the tube 200. The distal end of the electrical conductor 300 is electrically connected to the header 100. The distal end of connector 100 is removably attached to and electrically connected to the occluding ablation device. The distal end of the connector 100 is used for connecting with a plugging ablation device, the distal end of the tube body 200 is fixedly arranged at the proximal end of the connector 100, and the tube body 200 extends along the axial direction.

The present embodiment differs from the second embodiment in that:

the outer diameter of the connection part 130 is larger than that of the insertion part 140, and the connector 100 further includes a pressing member 180 connected to the outer circumference of the insertion part 140, wherein the pressing member 180 is located at the distal end side of the connection part 130 and spaced from the distal end surface of the connection part 130. The distal end of the electrical conductor 300 is fixedly disposed in the space between the pressing member 180 and the connection part 130, specifically, the electrical conductor 300 is a wire which is clamped between the pressing member 180 and the connection part 130. It should be noted that, the interval between the connection portion 130 and the pressing member 180 may be understood as the fixing groove 170 in the above embodiment.

In this embodiment, the outer periphery of the plugging portion 140 is provided with an external thread, and the pressing member 180 is a nut screwed on the plugging portion 140. The outer diameter of the pressing member 180 is not greater than the outer diameter of the connection part 130.

Fig. 9 is a schematic cross-sectional view of a fifth embodiment of the catheter of the invention. Fig. 10 is a schematic view showing a part of the construction of a fifth embodiment of the catheter of the present invention.

Referring to fig. 9 and 10, in the present embodiment, the catheter includes a connector 100 for connecting to the plugging ablation device, a tube 200 connected to an end of the connector 100 facing away from the plugging ablation device, and an electrical conductor 300 penetrating the tube 200. The distal end of the electrical conductor 300 is electrically connected to the header 100. The distal end of connector 100 is removably attached to and electrically connected to the occluding ablation device. The distal end of the connector 100 is used for connecting with a plugging ablation device, the distal end of the tube body 200 is fixedly arranged at the proximal end of the connector 100, and the tube body 200 extends along the axial direction.

The structures and connection relationships of the connector 100, the pipe 200, and the conductor 300 are referred to the structures of the connector 100, the pipe 200, and the conductor 300 in the third embodiment or the fourth embodiment, and are not described herein.

The present embodiment is different from the third and fourth embodiments in that:

in this embodiment, the tube body 200 further includes a mesh-grid braid 230, where the mesh-grid braid 230 wraps the outer periphery of the inner layer and extends along the axis of the inner layer 210; mesh 230 is heat staked between inner layer 210 and outer layer 220. In this embodiment, the mesh 230 is a metal mesh. In some embodiments, mesh 230 is made of other materials.

The distal end of the inner layer 210 and the distal end of the mesh braid 230 are inserted into the inner cavity 110 of the connector 100, and the mesh braid 230 is attached to the inner peripheral wall of the inner cavity 110 of the connector 100. In the embodiment where mesh 230 is made of a metal material, mesh 230 and connector 100 are insulated from each other. For example, an insulating material is sandwiched between the mesh 230 and the connector 100, for example, an insulating device is sandwiched between the mesh 230 and the connector 100, or an insulating layer is provided on the surfaces of the mesh 230 and the connector 100.

The inner cavity 110 of the connector 100 is formed with a step surface between the connecting portion 130 and the inserting portion 140, the inner diameter of the connecting portion 130 is larger than the inner diameter of the inserting portion 140, the connecting portion 130 is sleeved on the outer periphery of the inner layer 210, and the inner cavity of the inserting portion 140 is communicated with the cavity of the inner layer 210. The outer layer 220 of the pipe body 200 is made of thermoplastic material, and the outer layer 220 is heat-fused and covers the connection portion 130 of the connector 100.

When the outer layer 220 is heat-fused and coated on the connecting portion 130, the outer layer 220 can penetrate through the woven mesh 230 to be heat-fused and connected with the inner layer 210, so that the conductor 300 is pressed on the surface of the inner layer 210 on the basis of ensuring that the pipe body 200 has enough structural strength, the conductor 300 is prevented from bending towards the outer layer 220, and after heat-fusion shaping, the conductor 300 is caused to be at different positions in the axial direction and is not equidistant from the outer surface of the pipe body, particularly, a part of the conductor 300 is nearer to the outer surface of the pipe body, the conductor is easily exposed from the outer surface of the pipe body, or electric spark is easily generated on the surface of the pipe body when the conductor 300 transmits a high-voltage signal.

The outer layer 220 passes through the hollow window 160 at the hollow window 160 of the connecting portion 130 to connect the woven mesh 230 and the inner layer 210 by hot melting, so that the connection between the connector 100 and the pipe body is more compact and reliable.

The portion of the electrical conductor 300 remote from the connector 100 is located within the wall thickness of the tube 200. In this embodiment, the portion of the conductor 300 away from the connector 100 is sandwiched between the mesh 230 and the inner layer 210. In some embodiments, the portion of electrical conductor 300 distal from connector 100 is sandwiched between mesh braid 230 and outer layer 220 of body 200.

As shown in fig. 9, the fixing groove 170 is formed at the connection portion between the connection portion 130 and the plug portion 140, and the fixing groove 170 extends radially toward the inner periphery of the plug portion 140. Specifically, the plug portion 140 on both sides in the axial direction of the fixing groove 170 is flush with the outer circumferential wall of the connection portion 130, specifically, the portion of the plug portion 140 distal to the fixing groove 170 is a convex ring, the outer circumferential wall of the convex ring is not flush with the outer circumferential wall of the distal end of the plug portion 140, the outer diameter of the convex ring is larger than the outer diameter of the plug portion 140, the inner circumferential wall of the convex ring is flush with the inner circumferential wall of the distal end of the plug portion 140, the inner circumferential wall of the connection portion 130 at the position adjacent to the fixing groove 170 in the axial direction is flush with the inner circumferential wall of the plug portion 140, further, the distal inner circumferential wall of the connection portion 130 is flush with the inner circumferential wall of the distal end of the plug portion 140, and therefore, the depth of the fixing groove 170 extends from the outer circumferential wall of the connection portion 130 to a depth close to the inner circumferential wall of the plug portion 140, and the depth of the fixing groove 170 is larger than the thickness of the connection portion and than the thickness of the distal end of the plug portion (the portion excluding the convex ring in the plug portion).

In other embodiments, the outer peripheral wall of the collar may have an outer diameter smaller than the outer peripheral wall of the connection portion 130 and larger than the outer peripheral wall of the distal end of the insertion portion 140. In other embodiments, the inner peripheral wall of the connecting portion 130 axially adjacent to the fixing groove 170 has an inner diameter smaller than the inner diameter of the distal end of the connecting portion and larger than the inner diameter of the distal end of the connecting portion.

Referring to fig. 11, in this embodiment, the catheter includes a connector 100 for connecting to the plugging ablation device, a tube 200 connected to an end of the connector 100 opposite to the plugging ablation device, and an electrical conductor 300 penetrating the tube 200. The distal end of the electrical conductor 300 is electrically connected to the header 100. The distal end of connector 100 is removably attached to and electrically connected to the occluding ablation device. The distal end of the connector 100 is used for connecting with a plugging ablation device, the distal end of the tube body 200 is fixedly arranged at the proximal end of the connector 100, and the tube body 200 extends along the axial direction.

The connector 100 is provided with an inner cavity 110 which is penetrated along the axial direction, and the inner cavity 110 is penetrated along the axial direction through the proximal end and the distal end of the connector 100. The tube body 200 has a tubular structure with a lumen 290 formed therein, the inner cavity 110 of the connector 100 is communicated with the lumen 290 of the tube body 200, and a channel for passing a mapping catheter, a guiding guide wire and the like is formed between the inner cavity 110 and the lumen 290.

The connector 100 is made of conductive material, and the insertion portion 140 of the connector 100 extends into the plugging ablation device in the axial direction and is detachably connected to the plugging ablation device. The outer circumference of the insertion part 140 is provided with external threads to be screwed with the plugging ablation device. The structure of the connector 100 refers to the structure of the connector 100 in any of the above embodiments, and will not be described herein.

The electrical conductor 300 extends along the axial direction of the tube body 200, and the electrical conductor 300 is positioned within the lumen of the tube body 200. The distal end of the conductive body 300 is inserted into the connection portion 130 and is connected to the connection portion 130 by welding, pasting, hot melting, or the like to electrically connect the connection head 100.

The conductive body 300 is a conductive wire, the conductive wire is a metal wire, the distal end of the conductive wire is disposed in the extension channel 120, and the portion of the conductive wire facing away from the connector 100 is disposed in the lumen 290 of the tube body 200. In some embodiments, the connector 100 is provided with the fixing groove 170 of the above embodiment, and the distal end of the electrical conductor 300 is fixed in the fixing groove 170.

In this embodiment, the distal end of the tube 200 includes an integrally formed inner wall 250 and outer wall 260; the inner wall 250 and the outer wall 260 are disposed at a radial interval, and the proximal end of the inner wall 250 and the outer wall 260 are integrally connected; the connection 130 is clamped between the inner wall 250 and the outer wall 260.

The pipe body 200 is made of PA, PEBAX, HDPE and the like, the distal end of the outer wall 260 protrudes inward in the radial direction, and the distal end of the outer wall 260 is overlapped on the step between the connection part 130 and the socket part 140, thereby enhancing the stability of the connection of the pipe body 200 and the connection head 100. The pipe body 200 is integrally formed, the pipe body 200 and the connector 100 are not required to be connected in a hot melting mode, a corresponding hollowed-out window is not required to be formed on the connector 100, and the production and processing procedures are saved, so that the production efficiency is improved, and the production cost is reduced.

Referring to fig. 12, in this embodiment, the catheter includes a connector 100 for connecting to the plugging ablation device, a tube 200 connected to an end of the connector 100 opposite to the plugging ablation device, and an electrical conductor 300 penetrating the tube 200. The distal end of the electrical conductor 300 is electrically connected to the header 100. The distal end of connector 100 is removably attached to and electrically connected to the occluding ablation device. The distal end of the connector 100 is used for connecting with a plugging ablation device, the distal end of the tube body 200 is fixedly arranged at the proximal end of the connector 100, and the tube body 200 extends along the axial direction.

In the present embodiment, the structures and connection relationships of the connector 100, the tube 200 and the conductor 300 refer to the structures of the connector 100, the tube 200 and the conductor 300 in the sixth embodiment of the catheter, and are not described herein.

The wire as the conductor 300 in the present embodiment is covered with the insulating sheath 310 at the outer periphery thereof, so that the loss of energy can be reduced. And when the catheter moves in the human body component, the damage to the human body can be effectively avoided. It should be noted that, in any of the above embodiments, the insulation sleeve 310 wrapped around the outer circumference of the wire can reduce energy loss and effectively avoid damage to the human body.

Referring to fig. 11 to 13, in the present embodiment, the catheter includes a connector 100 for connecting to the plugging ablation device, a tube 200 connected to an end of the connector 100 opposite to the plugging ablation device, and an electrical conductor 300 penetrating the tube 200. The distal end of the electrical conductor 300 is electrically connected to the header 100. The distal end of connector 100 is removably attached to and electrically connected to the occluding ablation device. The distal end of the connector 100 is used for connecting with a plugging ablation device, the distal end of the tube body 200 is fixedly arranged at the proximal end of the connector 100, and the tube body 200 extends along the axial direction.

The connector 100 is provided with an inner cavity 110 which is penetrated along the axial direction, and the inner cavity 110 is penetrated along the axial direction through the proximal end and the distal end of the connector 100. The tube body 200 has a tubular structure with a lumen 290 formed therein, the inner cavity 110 of the connector 100 is communicated with the lumen 290 of the tube body 200, and a channel for passing a mapping catheter, a guiding guide wire, etc. is formed between the inner cavity 110 and the lumen 290.

In this embodiment, a plurality of lumens 290 are disposed in the tube body 200, the conductive body 300 is a conductive wire, the distal end of the conductive wire is disposed in the connection portion 130, and the portion of the conductive wire facing away from the connector 100 is disposed in one lumen 290 of the tube body 200. Other lumens 290 are used for the passage of mapping catheters or guide wires, etc., and multiple lumens 290 do not interfere with each other.

In the related art, two ablation assemblies are provided on the plugging ablation device for transmitting the same or different ablation power, and in some embodiments, one is connected to the positive output end of the signal source output, and the other is connected to the negative output end of the signal source.

The application provides a plugging ablation system, which comprises a catheter and a plugging ablation device, wherein the catheter is provided by the embodiment of the application; the occluding ablation device is attached to and detachable from the distal end of the catheter. The catheter is used for conveying and releasing the plugging ablation device to the tissue defect and can transmit ablation electric energy to the plugging ablation device. The occlusion ablation device is used for occluding a tissue defect and can ablate the tissue by utilizing electric energy, and in some embodiments, the occlusion ablation device can selectively ablate or map the tissue; the plugging ablation device is detachably connected to the distal end of the connector.

Fig. 15 is a schematic view of a structure of an occluding ablation device.

Referring to fig. 15, the present application provides an occlusive ablation device 50, where the portion of the occlusive ablation device 50 proximal to the catheter is a sealing portion 510 and the portion distal to the catheter is an anchoring portion 520. Taking fig. 1 as an example, in fig. 1, a proximal portion (lower side surface) is a sealing portion 510, a distal portion (upper side portion) is an anchoring portion 520, and the sealing portion 510 and the anchoring portion 520 are connected by a connecting member 530.

The plugging ablation device 50 is provided with an ablation member, specifically, the sealing portion 510 is provided with a first ablation member 540, and the anchoring portion 520 is provided with a second ablation member 550; the sealing portion 510 is provided with a first electrical conductor 560 electrically connected to the first ablating member, and the anchoring portion 520 is provided with a second electrical conductor 570 electrically connected to the second ablating member 550. The catheter assembly provided in this embodiment of the present application correspondingly provides a first catheter and a second catheter to supply power to the first electrical conductor 560 and the second electrical conductor 570, respectively. It should be noted that, in some embodiments, only the sealing portion 510 is provided with an ablation element or only the anchoring portion 520 is provided with an ablation element, and the corresponding sealing portion 510 or anchoring portion 520 is provided with an electrical conductor. The first electrical conductor 560 and the second electrical conductor 570 are disposed at intervals in the axial direction, the first electrical conductor 560 is disposed on the proximal end side of the second electrical conductor 570, specifically, the first electrical conductor 560 is disposed on the proximal end of the sealing portion 510, and the second electrical conductor 570 is disposed on the distal end of the connecting member 530.

The first ablating member 540 and the second ablating member 550 are configured to deliver the same or different ablative electrical energy to tissue. The first ablating member 540 and the second ablating member 550 are configured to be electrically connected to the catheter via an electrical conductor, respectively, to thereby deliver two types of same or different ablative energy. The first ablating member 540 and the second ablating member 550 can also be used for electrophysiological signal mapping. For example, in one period, both the first and

second ablators

540, 550 are used for ablation, and in another period, both the first and

second ablators

540, 550 are used for mapping, or portions of the first and

second ablators

540, 550 are used for ablation at all times, and portions of the first and

second ablators

540, 550 are used for mapping at all times.

It should be noted that, the ablation energy in this embodiment may be pulse energy, radio frequency energy, microwave energy, etc., and is not specifically limited herein.

The first ablating member 540 may be a conductive metal skeleton on the sealing portion 510, or may be an electrode disposed on the sealing portion 510. Similarly, the second ablating member 550 may be a metal skeleton on the anchor 520 or an electrode provided on the anchor 50. The electrode is in the form of a ring electrode, a dot electrode, a rod electrode and the like. In the configuration shown in fig. 1, the first ablating member 540 is an at least partially conductive metal skeleton on the sealing portion 510, and the second ablating member 550 is an electrode disposed on the anchoring portion 520, the electrode being in the form of a wire or sheet disposed circumferentially around the anchoring portion.

The positions of the first and second

ablative members

540 and 550 are not limited, that is, both of the ablative portions may be disposed at the sealing portion 510, or may be disposed at the anchoring portion 520, and the specific implementation forms of the first and second

ablative members

540 and 550 are not limited. Accordingly, the specific arrangement positions of the first conductor 560 and the second conductor 570 are not limited.

The first conductor 560 and the second conductor 570 may be part of the connector 530, or may be separately provided on the connector 530. The first electrical conductor 560 is connected to the proximal end of the sealing portion 510. It will be appreciated that at least one portion of the connector 530 may be made of an insulating material to ensure that the first and second ablating members 540,550 are insulated from each other and the sealing portion 510 is insulated from the anchoring portion 520.

It will be appreciated that, for clarity of illustration of the placement of the first electrical conductor 560 and the second electrical conductor 570, the cover is omitted from the device drawings, i.e., at least one cover may be provided in the occlusive ablation device for blocking the removal of thrombus from the left atrial appendage into the left atrium. The specific coating position may be set at the anchoring portion and/or the sealing portion, and is not limited.

The present embodiment provides a plugging ablation device with two ablation members, it can be appreciated that the plugging ablation device may be provided with only one ablation member, such as the first ablation member 540, and the first electrical conductor in the plugging ablation device is used to connect the connector 100 at the distal end of the catheter, so as to enable electrical connection with an external energy source.

In some embodiments, the occluding ablation device is provided with more than two ablative elements, and accordingly, each ablative element may be provided with an electrical conductor for connection to a corresponding catheter.

It will be appreciated that the plugging ablation device provided in this embodiment is a double-disc structure, i.e. the sealing portion and the anchoring portion are both disc-shaped, and in some embodiments the plugging ablation device is a single-disc structure (e.g. plunger-like) or a multiple-disc structure (e.g. three-disc or more). In this embodiment, the sealing portion is made by a braiding process, and the anchoring portion is made by a cutting process, and it is understood that the manufacturing process of the sealing portion and the anchoring portion is not limited, and the sealing portion and the anchoring portion may be made by a braiding process or a cutting process, respectively.

Referring to fig. 14 and 16, the present embodiment provides a catheter assembly for use with the occlusive ablation device provided in fig. 1, i.e., the distal end of the catheter assembly is used to connect the occlusive ablation device 50 and deliver and release the occlusive ablation device 50 into the patient, and the catheter assembly is also used to deliver the same or different ablative electrical energy to two ablative elements in the occlusive ablation device 50.

Specifically, the catheter assembly includes a first catheter 10 and a second catheter 20, both of which are referred to as the catheters in any of the embodiments described above for the first catheter 10 and the second catheter 20. The structures and connection relationships of the connectors 100, the tube 200, and the conductors 300 of the first and

second conduits

10 and 20 refer to the structures of the connectors 100, the tube 200, and the conductors 300 in any of the above embodiments, and are not described herein.

In this embodiment, the second catheter 20 is wrapped around the outer circumference of the first catheter 10, and the distal end of the first catheter 10 can exceed the distal end of the second catheter 20. Specifically, the distal end of the body 200 of the first catheter 10 can extend beyond the distal end of the body 200 of the second catheter 20; the two connectors 100 are arranged at intervals along the axial direction, and one connector 100 is connected to the distal end of the tube body 200 of the first catheter 10; the other connector 100 is connected to the distal end of the tube body 200 of the second catheter 20; the two connectors 100 are connected to corresponding conductors 300, respectively.

Both connectors 100 are detachably connected to the plugging ablation device for delivering the same or different ablation power to the plugging ablation device. The connector 100 of the first catheter 10 is adapted to connect to the second electrical conductor 570 of the occluding and ablating device 50 and the connector 100 of the second catheter 20 is adapted to connect to the first electrical conductor 560 of the occluding and ablating device 50. In some embodiments, two connectors 100 are used to transmit the output energy of the positive and negative delivery ends, respectively, of the external ablation energy generation device.

The first catheter 10 and the second catheter 20 can perform relative movement to drive the two connectors 100 to be separated from the plugging ablation device respectively. In this embodiment, the connector 100 is detachably connected to the plugging ablation device by means of a threaded connection. The first catheter 10 can slide axially and rotate radially relative to the second catheter 20 to drive the two connectors 100 to separate from the plugging ablation device. In one embodiment, the connectors 100 are axially detachably connected to the plugging ablation device, and the first catheter 10 can slide axially relative to the second catheter 20 to drive the two connectors 100 to separate from the plugging ablation device.

In this embodiment, the outer circumference of the tube body 200 of the first catheter 10 is provided with an insulating layer 280, and the insulating layer 280 covers at least the proximal end portion of the connector 100 on the first catheter 10 to increase the breakdown voltage between the first catheter 10 and the second catheter 20, thereby facilitating the transmission of high-voltage pulse energy. The insulating layer 280 may be a heat-shrinkable film with a smaller dielectric constant such as ET or PTFE, and the insulating layer 280 is sleeved on the outer periphery of the tube body 200 of the first catheter 10. Alternatively, the insulating layer 280 is one or more insulating coatings, such as a parylene coating, a PTFE coating, a PI coating, etc., applied to the proximal portion of the connector 100 on the first catheter 10. In some embodiments, insulating layer 280 covers the proximal end of connector 100, such as the connection portion of connector 100, and may extend proximally of first tube 10 to cover a greater extent. In some embodiments, the inner or outer circumference of the second conduit 20 is provided with an insulating layer as described above, which covers at least the proximal end of the connector 100 in the second conduit 20.

The two connectors 100 are correspondingly connected with two conductors 300, and the conductors 300 connected with the connectors 100 on the second conduit 20 are clamped between the pipe body 200 of the first conduit 10 and the pipe body 200 of the second conduit 20; the electric conductor 300 connected to the connector 100 on the first catheter 10 is sandwiched between the tube 200 of the first catheter 10 and the corresponding mesh braid 230.

In this embodiment, the first catheter 10 includes a connector 100 for connecting to an ablation blocking device, a tube 200 connected to an end of the connector 100 facing away from the ablation blocking device, and an electrical conductor 300 penetrating the tube 200. The second catheter 20 comprises a connector 100 for connecting an ablation occlusion device, a tube 200 connected to an end of the connector 100 facing away from the ablation occlusion device, and an electrical conductor 300 penetrating the tube 200.

In this embodiment, the structures of the connectors 100 and the conductors 300 of the first and

second conduits

10 and 20 and the structures of the connectors 100 and the conductors 300 in the previous conduit assembly embodiment are not described herein.

The first catheter 10 and the second catheter 20 in this embodiment are different from those in the previous catheter assembly embodiment in that:

The body 200 of the first catheter 10 includes an outer layer 201, a mesh-grid braid 230 bonded to the inner peripheral wall of the outer layer 201, and an inner layer 240 bonded to the inner peripheral surface of the mesh-grid braid. The inner layer 240 may be made of a PTFE film.

The body 200 of the second catheter 10 includes only an extension tube 202. The extension tube 202 is sleeved on the outer periphery of the outer layer 201, and the distal end of the outer layer 201 extends distally beyond the extension tube 202. The body 200 of the first catheter 10 and the body 200 of the second catheter 20 are integrally formed, so that the two connectors 100 can be driven to be separated from the plugging ablation device at the same time. Specifically, the extension pipe 202 and the first extension pipe 201 are integrally molded such that the extension pipe 202 and the first extension pipe 201 are provided as one body.

The electrical conductor 300 on the first catheter 10 is sandwiched between the outer layer 201 and the corresponding mesh 230, or between the mesh 230 and the inner layer 240. The electrical conductor 300 of the second catheter 10 is sandwiched between the extension tube 202 and the outer layer 201.

It will be appreciated that the present embodiment provides a catheter form in which one conductor and two conductors are disposed in a corresponding occlusion ablation device, and in an embodiment in which more than two conductors are disposed in an occlusion ablation device, a split nesting design may be added to a plurality of catheters with reference to the embodiment of fig. 14, or a nesting design in which a plurality of catheters are integrally formed with a connector with reference to the embodiment of fig. 16.

Fig. 17 is a schematic view of a connector according to the present invention.

Referring to fig. 17, the present embodiment provides a connector 400, and the connector 400 may be used in place of the connector 100 in any of the above embodiments. The connector 400 includes a connection portion 430 and a plug portion 440 protruding from a distal end of the connection portion 430; the connection portion 430 and the socket portion 440 extend in the axial direction; the plug 440 is adapted to be removably coupled to the occluding ablation device. The connecting portion 430 is provided with an extension channel 420.

The insertion portion 440 includes a spring 441, and the spring 441 is configured to expand or contract radially with respect to the connection portion 430 to connect or disconnect with the plugging ablation device.

In the present embodiment, the plug portion 440 includes two plug segments 442 disposed at intervals along the axial direction, and a plurality of elastic sheets 441 disposed between the two plug segments 442; a plug section 442 is connected to the distal end of the connection portion 430; two ends of the plurality of elastic sheets 441 are respectively connected with two plug-in sections 442; the plurality of spring plates 441 are distributed around the axis of the inserting portion 440. The plug portion 440 and the plugging ablation device are detachably connected by using the elastic force of the elastic sheet 441. When the catheter is connected with or disconnected from the plugging ablation device, the catheter only needs to be moved along the axial direction, and the catheter does not need to be rotated.

In the application, the conductor 300 is arranged in the extension channel (120, 420) of the connector (100, 400) in a penetrating way, so that the connection of the conductor 300 on the connector (100, 400) can not influence the inner diameter and the outer diameter of the connector (100, 400), and the connector (100, 400) is provided with electric energy on the basis of not increasing the outer diameter of the catheter.

The connector 100 in any of the embodiments of the present application may be replaced with the connector 400. The connection portion 440 of the connector 400 may adopt all specific technical solutions of the connection portion in the connector 100, which are not described herein.

The specific technical solutions in the above embodiments can be mutually used without contradiction.

While the invention has been described with reference to several exemplary embodiments, it is to be understood that the terminology used is intended to be in the nature of words of description and of limitation. As the present invention may be embodied in several forms without departing from the spirit or essential characteristics thereof, it should also be understood that the above-described embodiments are not limited by any of the details of the foregoing description, but rather should be construed broadly within its spirit and scope as defined in the appended claims, and therefore all changes and modifications that fall within the meets and bounds of the claims, or equivalences of such meets and bounds are therefore intended to be embraced by the appended claims.

Claims

1. A catheter for implanting an occluding ablation device in a patient, comprising:

the distal end of the connector is detachably connected with the plugging ablation device; when the connector is connected with the plugging ablation device, the connector is electrically connected with the plugging ablation device; the proximal end of the connector is provided with an extension channel;

The distal end of the tube body is fixedly arranged at the proximal end of the connector;

an electrical conductor extending in an axial direction of the tube body; the far end of the electric conductor penetrates through the extension channel and is electrically connected with the connector for conveying electric energy to the connector.

2. The catheter of claim 1, wherein the connector comprises a connection portion and a socket portion protruding distally of the connection portion; the connecting part and the inserting part extend along the axial direction; the plugging part is used for being detachably connected with the plugging ablation device; the extension channel is arranged at the proximal end of the connecting part, and the pipe body is connected to the connecting part.

3. The catheter of claim 2, wherein the extension channel is a guide groove opened on an outer circumferential surface of the connection portion.

4. The catheter according to claim 2, wherein the connector is provided with a fixing groove at a distal end of the extension channel, and an extension direction of the fixing groove is different from an extension direction of the extension channel; the distal end of the extension channel is communicated with the fixed groove, and the electric conductor is a wire; the distal end of the conductor is fixed in the fixing groove.

5. The catheter according to claim 4, wherein the fixing groove is provided circumferentially on an outer peripheral surface of the connecting portion around an axis of the connecting portion; the part of the far end of the electric conductor, which penetrates out of the extension channel, is wound in the fixing groove.

6. The catheter of claim 4, wherein the depth of the fixation groove in the radial direction is greater than the depth of the extension channel in the radial direction.

7. The catheter of claim 6, wherein the fixing groove is formed at a connection portion of the connection portion and the insertion portion; the fixing groove extends radially toward an inner periphery of the insertion portion.

8. The catheter of claim 4, wherein the width of the fixation groove edge is adapted to the diameter of the guide wire to compress the guide wire between the fixation groove sidewalls.

9. The catheter of claim 4, wherein a step is formed between the distal end of the connector and the hub, a boss is provided on the outer circumference of the hub at the distal end of the connector, the boss extends around the axis of the hub, the boss and the step are spaced apart, and the fixing groove is formed between the boss and the step.

10. A catheter as in claim 3, wherein the extension channel extends through a distal end of the connection portion; the distal end of the electrical conductor passes out of the extension channel; the distal end of the conductor is connected to the outer periphery of the connection portion or to the distal end face of the connection portion.

11. The catheter of claim 10, wherein the connector further comprises a compression member attached to the outer periphery of the plug portion, the proximal end face of the compression member being compressed against the electrical conductor to compress the electrical conductor between the compression member and the connector portion.

12. The catheter of claim 2, wherein a lumen is provided within the tube, and wherein a distal end of the tube is wrapped around the outer circumference of the connection.

13. The catheter of claim 12, wherein the distal end of the tube has a wall thickness D at the location of the connection and the tube has a wall thickness D at the location of the connection, wherein D-D <0.2mm.

14. The catheter according to claim 12, wherein the connector is provided with an axially through cavity, the cavity being in communication with the lumen of the tube; the pipe body comprises an inner layer and an outer layer coated on the periphery of the inner layer; the distal end of the inner layer extends into the inner cavity of the connector and is attached to the inner periphery of the connector; the outer layer covers the periphery of the connecting portion.

15. The catheter of claim 14, wherein the connection portion and the hub are each tubular; the external diameter of the connecting part is larger than that of the inserting part.

16. The catheter of claim 15, wherein a distal outer periphery of the inner layer is affixed to an inner periphery of the connection portion; the inner peripheral wall of the inner layer is flush with the inner peripheral wall of the plug-in connection part.

17. The catheter of claim 14, wherein a hollowed-out window penetrating through the inner cavity is radially formed in the outer periphery of the connecting portion, and the outer layer of the catheter body is connected to the inner layer through the hollowed-out window in a hot-melt manner.

18. The catheter of claim 14, wherein the tube further comprises a mesh braid wrapped around the outer circumference of the inner layer and extending along the axis of the inner layer; the woven mesh is connected between the inner layer and the outer layer in a hot melt manner; the part of the conductor, which is far away from the connector, is clamped between the woven mesh and the outer layer or between the woven mesh and the inner layer.

19. The catheter of claim 2, wherein the distal end of the tube comprises integrally formed inner and outer walls; the inner wall and the outer wall are arranged at intervals along the radial direction, and the proximal end of the inner wall is connected with the outer wall into a whole; the connecting part is clamped between the inner wall and the outer wall; the electric conductor is a wire, and the part of the electric conductor far away from the connector is positioned in the pipe cavity of the pipe body or in the wall thickness range of the pipe body.

20. The catheter of claim 19, wherein a plurality of lumens are provided within the catheter body, wherein a portion of the electrical conductor distal from the connector is received within one of the lumens.

21. The catheter of claim 2, wherein the hub is provided with external threads on its outer circumference for connection with a plugging ablation device.

22. The catheter of claim 18, wherein the mesh is insulated from the connector.

23. The catheter of claim 4, wherein the wire surface is covered with an insulating sleeve.

24. A catheter assembly comprising a first catheter and a second catheter, both of which are the catheter of any one of claims 1-23; the second catheter is wrapped on the periphery of the first catheter, and the distal end of the first catheter can exceed the distal end of the second catheter.

25. The catheter assembly of claim 24, wherein the outer circumference of the body of the first catheter is provided with an insulating layer covering at least a proximal portion of the connector on the first catheter.

26. The catheter assembly of claim 24, wherein the first catheter is axially slidable relative to the second catheter and radially rotatable to drive the corresponding connector to separate from the occlusion ablation device, respectively.

27. The catheter assembly of claim 24, wherein the tube of the first catheter and the tube of the second catheter are integrally provided.

28. A plugging ablation system comprising a plugging ablation device and at least one catheter according to any one of claims 1-23; the plugging ablation device is used for plugging tissue defects and can ablate the tissues by utilizing electric energy; the plugging ablation device is detachably connected to the far end of the connector, and the catheter is used for conveying and releasing the plugging ablation device to a tissue defect position and can transmit ablation electric energy to the plugging ablation device.