WO2022171045A1

WO2022171045A1 - Left atrial appendage occlusion and ablation system

Info

Publication number: WO2022171045A1
Application number: PCT/CN2022/075298
Authority: WO
Inventors: 李建民; 尤岩; 吴能标; 丘家明
Original assignee: 杭州德诺电生理医疗科技有限公司
Priority date: 2021-02-09
Filing date: 2022-01-31
Publication date: 2022-08-18
Also published as: CN217772490U; CN114903587A

Abstract

A left atrial appendage occlusion and ablation system. The left atrial appendage occlusion and ablation system comprises an occlusion and ablation apparatus (100) and a delivery apparatus (200); the occlusion and ablation apparatus (100) comprises a support body, an ablation assembly (20), and a conductive connection member (30), the support body being able to radially expand and contract; the ablation assembly (20) is arranged on the support body; the conductive connection member (30) is electrically connected between the delivery apparatus (200) and the ablation assembly (20); and the conductive connection member (30) and the delivery apparatus (200) achieve mutual connection or separation by means of relative rotation.

Description

Left atrial appendage closure and ablation system

technical field

The invention relates to the field of medical devices, in particular to a left atrial appendage occlusion and ablation system.

Background technique

Atrial fibrillation (atrial fibrillation for short) is the most common sustained cardiac arrhythmia. The incidence of atrial fibrillation increases with age, reaching 10% of people over the age of 75.

Because of its special shape and structure, the left atrial appendage is not only the most important site for thrombosis in atrial fibrillation (AF), but also one of the key areas for its occurrence and maintenance. The left atrial appendage occlusion and ablation device uses a special occluder to occlude the left atrial appendage, so as to prevent atrial fibrillation and thromboembolism. It is a less invasive and less time-consuming treatment method developed in recent years.

At present, in the related art, a left atrial appendage occlusion and ablation device has been developed, which is usually implanted into the mouth of the left atrial appendage through a delivery device. The left atrial appendage occlusion and ablation device is provided with an ablation component for electrically ablating the tissue of the left atrial appendage. , in which a plug-and-pull separation scheme is adopted between the ablation component and the conductive cable in the delivery device, that is, after the left atrial appendage ablation occluder is implanted to the target position and the ablation is completed, the surgeon needs to pull the conductive cable to the proximal end to The ablation component is separated from the conductive cable, and the subsequent conductive cable is withdrawn from the body along with the delivery device.

However, in the process of separating the conductive cable from the ablation component, if the conductive cable is detached from the left atrial appendage occlusion and ablation device only if the pulling force is large, the left atrial appendage occlusion and ablation device is easily pulled through the conductive cable, thereby causing the left atrial appendage to be occluded. The ablation device is displaced; if the surgeon's pulling force is too small, the conductive cable and the ablation component are not easily separated. Therefore, the manufacturing process accuracy of the connection position between the ablation component and the conductive cable should be very high, and it is necessary to avoid insufficient connection strength between the two leading to unstable electrical connection, and excessive connection strength between the two leading to the separation process. The conductive cable is broken, or the left atrial appendage closure and ablation device is displaced after separation.

SUMMARY OF THE INVENTION

In order to solve the above-mentioned technical problems, the present invention adopts the following technical solutions:

According to one aspect of the present invention, the present invention provides a left atrial appendage occlusion and ablation system. The left atrial appendage occlusion and ablation system includes an occlusion and ablation device and a delivery device. The occlusion and ablation device is implanted and occluded in the left atrial appendage. At the opening, the delivery device is used to deliver the occlusion and ablation device to the opening of the left atrial appendage; the occlusion and ablation device comprises: a support frame capable of radial expansion and contraction, and used to block the opening of the left atrial appendage; ablation an assembly, arranged on the support frame, and used for transmitting ablation electrical energy to the left atrial appendage tissue and/or collecting electrophysiological signals of the left atrial appendage tissue; a conductive connector for electrically connecting the delivery device and the ablation component between; the conductive connector and the conveying device are connected or disconnected from each other through relative rotation.

As can be seen from the above technical solutions, the embodiments of the present invention have the following advantages and positive effects:

In the left atrial appendage occlusion and ablation system of the present invention, the occlusion and ablation device is used to cooperate with the delivery device, the delivery device is used to deliver the occlusion and ablation device to the opening of the left atrial appendage, and the occlusion and ablation device is used to implant and seal the left atrial appendage. Heart open. The occlusion and ablation device includes a support frame, an ablation component and a conductive connector; the conductive connector is electrically connected to the delivery device and the ablation component, and the conductive connector and the delivery device are connected or disconnected from each other through relative rotation, thereby avoiding Axial plug-in separation leads to the problem that the manufacturing process precision of the connection position between the ablation component and the delivery device must be very high, which in turn helps to reduce the manufacturing process precision requirements.

Description of drawings

FIG. 1 is a schematic structural diagram of a left atrial appendage occlusion and ablation system according to a first embodiment of the present invention.

FIG. 2 is a schematic view of the structure of the conveying device and the conductive connector in FIG. 1 .

FIG. 3 is another structural schematic diagram of the conveying device and the conductive connecting piece in FIG. 2 .

FIG. 4 is a schematic structural diagram of the clamping sleeve of the conductive connector in FIG. 3 .

FIG. 5 is a schematic three-dimensional structural diagram of the conductive connector in FIG. 3 .

FIG. 6 is a schematic three-dimensional structural diagram of the clamping jaw of the conductive connector in FIG. 5 .

FIG. 7 is another structural schematic diagram of the conductive connector.

FIG. 8 is a schematic structural diagram of a conveying device matched with the conductive connector in FIG. 7 .

FIG. 8a is a schematic three-dimensional structural diagram of another alternative of the conducting member of the delivery device in FIG. 8 .

Fig. 8b is a top view of the conductive member shown in Fig. 8a.

FIG. 8c is a schematic three-dimensional structural diagram of the conducting member shown in FIG. 8a from another angle.

FIG. 8d is a schematic three-dimensional structural diagram of another alternative of the conducting member of the delivery device in FIG. 8 .

Figure 8e is a top view of the conductive member shown in Figure 8d.

FIG. 8f is a schematic three-dimensional structural diagram of the conducting member shown in FIG. 8d from another angle.

FIG. 9 is a schematic three-dimensional structural diagram of another alternative of the conducting member of the delivery device in FIG. 8 .

FIG. 10 is a top view of the conductive member shown in FIG. 9 .

FIG. 11 is a schematic three-dimensional structural diagram of the conducting member shown in FIG. 9 from another angle.

FIG. 12 is another three-dimensional schematic diagram of the conductive connector.

Fig. 13 is a side view of the conductive connector of Fig. 12, wherein only one snap groove is shown.

FIG. 14 is a schematic structural diagram of a conductive member matched with the conductive connector in FIG. 12 .

FIG. 15 is a schematic view of the assembly of the conductive connecting member of FIG. 12 and the conductive member of FIG. 14 .

16 is a schematic structural diagram of a left atrial appendage occlusion and ablation system according to a second embodiment of the present invention.

FIG. 17 is a schematic structural diagram of a left atrial appendage occlusion and ablation system provided by a third embodiment of the present invention.

FIG. 18 is a schematic structural diagram of a left atrial appendage occlusion and ablation system according to a fourth embodiment of the present invention.

FIG. 19 is a schematic structural diagram of a left atrial appendage occlusion and ablation system provided by a fifth embodiment of the present invention.

FIG. 20 is a schematic structural diagram of a left atrial appendage occlusion and ablation system provided by a sixth embodiment of the present invention.

FIG. 21 is a schematic structural diagram of a left atrial appendage occlusion and ablation system provided by a seventh embodiment of the present invention.

FIG. 22 is a schematic structural diagram of the conveying device in FIG. 21 .

23 is a schematic structural diagram of a left atrial appendage occlusion and ablation system according to an eighth embodiment of the present invention.

FIG. 24 is a schematic diagram of the structure of the conveying device and the conductive connector in FIG. 23 .

FIG. 25 is a schematic structural diagram of a left atrial appendage occlusion and ablation system provided by the ninth embodiment of the present invention.

FIG. 26 is a schematic structural diagram of the delivery device of the left atrial appendage occlusion and ablation system in FIG. 25 .

FIG. 27 is another structural schematic diagram of the delivery device and the conductive connector of the left atrial appendage occlusion and ablation system in FIG. 25 .

FIG. 28 is a schematic structural diagram of a left atrial appendage occlusion and ablation system according to a tenth embodiment of the present invention.

FIG. 29 is a schematic structural diagram of the occlusion and ablation device of the left atrial appendage occlusion and ablation system provided by the eleventh embodiment of the present invention.

FIG. 30 is a schematic structural diagram of the occlusion and ablation device of the left atrial appendage occlusion and ablation system according to the twelfth embodiment of the present invention.

FIG. 31 is a schematic structural diagram of the occlusion and ablation device of the left atrial appendage occlusion and ablation system provided by the thirteenth embodiment of the present invention.

FIG. 32 is a schematic structural diagram of the occlusion and ablation device of the left atrial appendage occlusion and ablation system provided by the fourteenth embodiment of the present invention.

FIG. 33 is a schematic structural diagram of the occlusion and ablation device of the left atrial appendage occlusion and ablation system provided by the fifteenth embodiment of the present invention.

FIG. 34 is a schematic structural diagram of a delivery device matched with the occlusion and ablation device shown in FIG. 33 .

FIG. 35 is a schematic structural diagram of a left atrial appendage occlusion and ablation system provided by the sixteenth embodiment of the present invention.

FIG. 36 is a schematic structural diagram of the occlusion and ablation device of the left atrial appendage occlusion and ablation system provided by the seventeenth embodiment of the present invention.

FIG. 37 is a schematic structural diagram of the occlusion and ablation device of the occlusion and ablation system provided by the eighteenth embodiment of the present invention.

Detailed ways

Exemplary embodiments embodying the features and advantages of the present invention will be described in detail in the following description. It should be understood that the present invention can have various changes in different embodiments without departing from the scope of the present invention, and the descriptions and drawings therein are essentially used for illustration rather than limitation this invention.

In the description of this application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", " rear, left, right, vertical, horizontal, top, bottom, inside, outside, clockwise, counterclockwise, etc., or The positional relationship is based on the orientation or positional relationship shown in the accompanying drawings, which is only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, Therefore, it should not be construed as a limitation on this application.

In addition, the terms "first" and "second" are only used for descriptive purposes, and should not be construed as indicating or implying relative importance or implying the number of indicated technical features. Thus, features defined as "first", "second" may expressly or implicitly include one or more of said features. In the description of the present application, "plurality" means two or more, unless otherwise expressly and specifically defined.

In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installed", "connected" and "connected" should be understood in a broad sense, for example, it may be a fixed connection or a detachable connection Connection, or integral connection; can be mechanical connection, can also be electrical connection; can be directly connected, can also be indirectly connected through an intermediate medium, can be internal communication between two elements. For those of ordinary skill in the art, the specific meanings of the above terms in this application can be understood in specific situations.

It should be noted that the features in the embodiments of the present invention may be combined with each other without conflict.

The left atrial appendage occlusion and ablation system according to the embodiment of the present invention includes an occlusion and ablation device and a delivery device. The left atrial appendage occlusion and ablation device is used to implant and seal the opening of the left atrial appendage, and to perform electrical ablation of the left atrial appendage tissue. The delivery device is used to deliver the left atrial appendage occlusion and ablation device to the opening of the left atrial appendage, and to transmit ablation energy to the left atrial appendage occlusion and ablation device.

Definition Interpretation:

Left atrial appendage opening: The junction of the left atrium and the left atrial appendage.

Proximal and distal ends: after the left atrial appendage occlusion and ablation device is implanted at the opening of the left atrial appendage, the proximal end of the component in the left atrial appendage occlusion and ablation device is the end of the component close to the left atrium, and the distal end of the component is the component close to the left atrium. The deep end of the heart ear. For the delivery device, along the delivery channel of the left atrial appendage occlusion and ablation device, the proximal end of the component in the delivery device is the end of the component close to the operator, and the distal end of the component is the end of the component away from the operator.

Insulation treatment: An insulating layer is formed on the surface of the part to insulate that part of the part. Specifically, the methods of insulation treatment include: coating insulation coating materials at the positions to be insulation treatment, coating materials including but not limited to parylene coating, PTFE (Poly-tetra-fluoroethylene, polytetrafluoroethylene) coating layer, PI (Polyimide, polyimide) coating; or, covering the insulating film at the position to be insulated, the film material includes but not limited to FEP (Fluorinated-ethylene-propylene, perfluoroethylene-propylene copolymer), PU (polyurethane, polyurethane), ETFE (ethylene-tetra-fluoro-ethylene, ethylene-tetrafluoroethylene copolymer), PFA (Polyfluoroalkoxy, tetrafluoroethylene-perfluoroalkoxy vinyl ether copolymer), PTFE , PEEK (poly-ether-ether-ketone, polyether ether ketone, polyether ether ketone, polyether ether ketone, polyether ether ketone), silica gel; or, in the position where insulation treatment is required to wear an insulating sleeve, the material of the insulating sleeve includes but is not limited to FEP, PU, ETFE, PFA , PTFE, PEEK, silicone.

The left atrial appendage occlusion and ablation system provided in the embodiments of the present invention is used to implant the occlusion device into the mouth of the left atrial appendage, and can ablate the left atrial appendage tissue, for example, by pulse ablation, radiofrequency ablation, or microwave ablation. Pulse ablation uses a high-intensity pulsed electric field to cause irreversible electrical breakdown of the cell membrane, which is called irreversible electroporation (IRE) in the medical field. The high-voltage pulse sequence produces less heat and does not require saline flushing for cooling, which can effectively reduce the occurrence of gas explosion, eschar and thrombosis. The pulse ablation treatment time is short, the treatment time of applying a group of pulse sequences is less than 1 minute, and the whole ablation time is generally not more than 5 minutes. And because the response thresholds of different tissues to the pulsed electric field are different, it provides the possibility to ablate the myocardium without disturbing other adjacent tissues, thereby avoiding accidental injury to the tissues adjacent to the left atrial appendage. In addition, compared with other energies, pulse ablation does not require heat conduction to ablate deep tissue, and all cardiomyocytes distributed above a certain electric field intensity will undergo electroporation, which reduces the requirement for catheter ablation pressure during ablation. Therefore, even if the occlusion and ablation device does not completely fit the inner wall of the left atrial appendage after entering the left atrial appendage, the IRE ablation effect will not be affected. The ablation components that apply pulse energy (such as the first ablation element and the second ablation element in the following) can also collect intracardiac electrical signals. The absolute refractory period of myocardial contraction, so as not to interfere with the heart rate and reduce sudden arrhythmias; after the ablation operation, it can also be judged by the intracardiac signal whether the tissue is completely electrically isolated.

For the first embodiment, refer to the structures shown in FIG. 1 and FIG. 2 .

FIG. 1 is a schematic structural diagram of a left atrial appendage occlusion and ablation system according to Embodiment 1 of the present invention. FIG. 2 is a schematic structural diagram of the conveying device 200 and the conductive connector 30 in FIG. 1 .

Referring to FIG. 1 and FIG. 2 , the left atrial appendage occlusion and ablation system according to the embodiment of the present invention includes an occlusion and ablation device 100 and a delivery device 200 . The occlusion ablation device 100 is used to implant and occlude the opening of the left atrial appendage. The delivery device 200 is used to deliver the occlusion and ablation device 100 to the opening of the left atrial appendage, and to transmit ablation electrical energy to the occlusion and ablation device 100 . The delivery device 200 and the occlusion and ablation device 100 are connected or disconnected from each other through relative rotation in the circumferential direction, and the delivery device 200 can transmit ablation power to the occlusion and ablation device 100 when connected.

After the occlusion and ablation device 100 is implanted into the opening of the left atrial appendage and the ablation operation is completed, the delivery device 200 and the occlusion and ablation device 100 are rotated relative to each other until they are separated from each other, and the mechanical and electrical connections are released. The occlusion ablation device 100 remains in the patient. Compared with the axial insertion and extraction separation solution in the related art, it avoids that the operator's pulling force is too small to be separated during the insertion and extraction process, and the delivery device 200 and the occlusion and ablation device 100 are separated from each other by relying on a larger pulling force, resulting in occlusion. The problem of displacement of the ablation device 100 and the breakage of the conductive cable in the delivery device 200 occurs, which reduces the requirement on the operator's separation pulling force in the process of separating the occlusion and ablation device 100, and reduces the delivery device 200 and the occlusion and ablation device. The requirements for the manufacturing process accuracy of the electrical connection positions between 100 and 100 improve the stability and safety of the system separation process.

Referring to FIG. 1 , in this embodiment, the occlusion and ablation device 100 is a single-disc structure, and the occlusion and ablation device 100 includes a support body, an ablation component 20 and a conductive connector 30 . The support body may be a support frame with a plurality of mesh holes formed on the support frame, and the support body may also be a balloon, which can be sealed and fixed to the left atrial appendage after being filled with a medium. The following description will be given by taking the support body as the support frame 10 as an example, and it can be understood that the following support frame 10 can be replaced by a balloon if there is no contradiction.

The support frame 10 is a grid-like frame structure which is cut or woven. The central axis of the support frame 10 is an axis extending from the proximal end to the distal end, and the support frame 10 is configured to be able to expand radially outward relative to the central axis, and to contract radially inward relative to the central axis, thereby forming a flexible A skeletal structure that expands or contracts radially.

The support frame 10 can be cut from a pipe made of elastic metal, or woven from a metal wire, or processed by partial weaving combined with partial pipe cutting. The two parts with different processes can be welded, bonded, melted, Stitched or fastened to each other by means of connectors. The material of the support frame 10 is a metal or a non-metal material, preferably a shape memory metal material, such as a nickel-titanium alloy material. In this embodiment, the support frame 10 is formed by cutting and shaping a nickel-titanium alloy pipe.

The proximal end of the support framework 10 is connected to the delivery device 200 . In the support frame 10 , the part of the support frame 10 close to the conveying device 200 is the sealing part 11 , and the part far from the conveying device 200 is the anchoring part 12 , and the sealing part 11 is connected to the anchoring part 12 . That is, the proximal part of the supporting frame 10 is the sealing part 11 , the distal part of the supporting frame 10 is the anchoring part 12 , and the sealing part 11 and the anchoring part 12 are an integral structure.

In this embodiment, the support frame 10 is in the shape of a plug, the proximal end is used to connect the delivery device, and is a sealing structure, and the distal end is open, that is, the distal end of the anchoring portion 12 is an open structure. It can be understood that, in some other embodiments, the distal end of the support frame 10 can also adopt a closed structure. In some embodiments, the occlusion and ablation device 100 includes at least one flow blocking membrane disposed on the support frame 10 . The blocking membrane is arranged on the inner side and/or the outer side of the support frame 10, and is used to block the thrombus inside the left atrial appendage from flowing out from the mouth of the left atrial appendage to the left atrium.

The ablation assembly 20 is disposed on the support frame 10, and the ablation assembly 20 is used for electrical connection with the distal end of the delivery device 200, and transmits ablation electrical energy to the inner wall of the left atrial appendage tissue to perform tissue ablation. The ablation assembly 20 can also be used for electrophysiological signal mapping, thereby realizing other functions such as cardiac mapping.

In this embodiment, the ablation assembly 20 may be an ablation electrode additionally disposed on the support frame 10, and the material of the ablation electrode may be platinum, iridium, gold, silver or other medical metals that can be used for interventional therapy. In this embodiment, the ablation electrode is a ring electrode. It can be understood that the ablation electrode can be not only a ring electrode, but also a sheet electrode, a point electrode, a strip electrode or a spherical electrode. Specific restrictions. Ablation electrodes can be used for both ablation and electrophysiological signal mapping.

In some embodiments, a portion of the support frame 10 may also be used directly as the ablation assembly 20 . Specifically, the support frame 10 is made of a metal conductive material, the exposed part of the metal on the support frame 10 is used as the ablation component 20 , the surface of the rest of the support frame 10 is insulated, and the ablation component 20 conducts an electrical signal to make the ablation component 20 The exposed part is ablated. The insulating treatment method can be performed by vacuum coating the surface of the conductive wire/rod to form an insulating coating, or other insulating methods mentioned above for insulating treatment.

It can be understood that the number and location of the ablation components 20 can be reasonably arranged as required.

It should be noted that, the ablation energy in this embodiment may be pulse, radio frequency, microwave, etc., which is not specifically limited here.

Please refer to FIG. 1 to FIG. 2 , the conductive connector 30 is disposed on the support frame 10 , the conductive connector 30 is used for conductive connection with the ablation component 20 , and the conductive connector 30 is used for connecting with the distal end of the delivery device 200 through circumferential The connection and disengagement are realized in the way of relative rotation. The delivery device 200 transmits ablation energy to the conductive connector 30 and through the conductive connector 30 to the ablation assembly 20 for tissue ablation.

After the tissue ablation is completed, the conductive connector 30 can be circumferentially disengaged from the distal end of the delivery device 200 , and the conductive connector 30 , the support frame 10 and the ablation component 20 remain in the left atrial appendage, which reduces the process of separating and occluding the ablation device 100 . The requirements on the operator's operation in the process reduce the requirements on the manufacturing process precision of the connection position between the delivery device 200 and the ablation assembly 20, and improve the stability and safety during the separation process of the system. In this embodiment, the conductive connecting member 30 is a tubular structure, and an inner thread structure is provided on the inner wall of the conductive connecting member 30 . The delivery device 200 includes a conducting member 210 , and an outer thread is provided on the outer peripheral wall of the conducting member 210 . The conductive member 210 is used for screw connection and electrical connection with the conductive connection member 30 , that is, the conductive member 210 can be connected to and disconnected from the conductive connection member 30 by means of screw-rotating connection.

It can be understood that, in some other embodiments, the internal and external thread structures on the conductive connector 30 and the delivery device 200 can be interchanged, that is, the conductive connector 30 is provided with external threads, and accordingly, the conductive member 210 of the delivery device 200 is provided with external threads. There are internal threads that cooperate with the external threads of the conductive connector 30 .

In this embodiment, the conductive connector 30 is disposed on the proximal end side of the support frame 10 , and the ablation component 20 is disposed near the proximal end side of the support frame 10 .

Further, in the present embodiment, the conductive connecting member 30 passes through the proximal end surface of the supporting frame 10 , the distal end of the conductive connecting member 30 protrudes from the distal side of the proximal end surface of the supporting frame 10 , and the The proximal end protrudes proximally of the proximal end face of the support frame 10 . That is, some of the conductive connectors 30 are arranged on the proximal side of the proximal end surface of the support frame 10 , and other parts are arranged at the distal side of the proximal end surface of the support frame 10 . In other embodiments, the proximal end surface of the conductive connector 30 may be flush with the proximal end surface of the supporting frame 10, or the proximal end surface of the conductive connector 30 may be disposed at the distal end relative to the proximal end surface of the supporting frame 10, that is, the conductive The connector 30 is concavely disposed on the proximal surface of the support frame 10 , that is, the conductive connector 30 does not protrude from the proximal end surface of the support frame 10 .

In this embodiment, the ablation assembly 20 includes an ablation electrode additionally disposed on the support frame 10 , and the ablation electrode can be electrically connected to the conductive connection member 30 through a first wire 201 .

Further, in this embodiment, the first wires 201 are connected to the distal ends of the conductive connecting members 30 , so the first wires 201 can be distributed inside the support frame 10 . Therefore, after the conductive member 210 of the delivery device 200 is separated from the conductive connection member 30 in the circumferential direction, the first lead wire 201 will not be exposed from the proximal end of the support frame 10, thus effectively reducing the possibility of device thrombosis.

Specifically, the first wire 201 may be made of the same material as the ablation electrode, or further extended from the end of the ablation electrode. The connection between the first wire 201 and the conductive connector 30 can be achieved by at least one of the following methods, such as welding, bonding, wrapping, overlapping, or using an additional crimping member to crimp the first wire 201 between the conductive connection 30 and the crimp.

FIG. 3 is another structural schematic diagram of the conveying device 200 and the conductive connecting member 30 in FIG. 2 . FIG. 4 is a schematic structural diagram of the clamping sleeve 31 of the conductive connector 30 in FIG. 3 . FIG. 5 is a schematic three-dimensional structural diagram of the conductive connector 30 in FIG. 3 .

Please refer to FIGS. 3 to 5 , and in conjunction with FIG. 1 , the structure of the delivery device 200 of this embodiment is similar to that of the delivery device 200 of the embodiment of FIG. 2 , and both can be applied to the occlusion and ablation device 100 of the embodiment of FIG. However, the structure of the conducting member 210 in this embodiment is different. In addition, the structure of the conductive connection member 30 of this embodiment is also different from that of the conductive connection member 30 in the embodiment of FIG. 2 . The electrical connection between the conveying device 200 and the conductive connector 30 in the embodiment of FIG. 2 is based on a screw connection, and the electrical connection between the conveying device 200 and the conductive connector 30 in the embodiment of FIG. 3 is based on the claw connection method.

Specifically, in this embodiment, the conductive connector 30 includes a clamping sleeve 31 and a clamping jaw 32 . Wherein, the clamping sleeve 31 is provided on the support frame 10 , and is provided through the center of the proximal end surface of the support frame 10 . The proximal end of the support frame 10 can be fixed on the outer wall of the clamping sleeve 31 by melting, gluing or using other additional fixing means. It should be noted that, in some other embodiments, the clamping sleeve 31 may also be provided at the distal end of the support frame 10 or at other positions.

In this embodiment, the clamping sleeve 31 is made of insulating material, that is, the clamping sleeve 31 is an insulating and non-conductive structure. It should be noted that, in some other embodiments, the clamping sleeve 31 can also be made of conductive material.

A receiving cavity 311 is formed in the clamping sleeve 31 through its distal end, and at least the inner diameter of the inner wall of the distal end of the clamping sleeve 31 is gradually reduced from the proximal end to the distal end, so that the inner wall of the distal end of the clamping sleeve 31 forms a proximal end The large tapered wall 3111 at the distal end makes the diameter of the distal end cavity of the receiving cavity 311 gradually decrease in the direction from the proximal end to the distal end.

Referring to FIG. 4 , further, in this embodiment, the inner wall of the proximal end of the clamping sleeve 31 forms a cylindrical wall 3112 whose inner diameter remains unchanged from the proximal end to the distal end. The distal end of the cylindrical wall 3112 is in contact with the proximal end of the conical wall 3111 , and the cylindrical wall 3112 and the conical wall 3111 jointly enclose a receiving cavity 311 . It should be noted that, the inner wall of the clamping sleeve 31 may only be provided with a tapered wall 3111 .

Please refer to FIGS. 3 to 5 , and in conjunction with FIG. 1 , the clamping claw 32 is movably disposed in the receiving cavity 311 of the clamping sleeve 31 , and the clamping claw 32 is made of conductive material. The clamping jaws 32 are used for connecting with the conductive member 210 and electrically connected with the conductive member 210 . At the same time, the clamping jaw 32 can also be used to clamp the first lead 201. The first lead 201 extends from the distal end of the receiving cavity 311 and is electrically connected to the ablation component 20, so that the conductive member 210 can provide ablation energy for the ablation component 20.

Referring to FIG. 5 a , the clamping jaw 32 includes a base 320 and a plurality of claw arms 321 movably disposed at the distal end of the base 320 . The plurality of claw arms 321 are arranged at intervals in the circumferential direction. There is a gap 322 between two adjacent claw arms 321 . The outer wall of the claw arm 321 faces the tapered wall 3111 , and the outer wall of the claw arm 321 has an arc-shaped surface 323 matched with the tapered wall 3111 . The outer wall of the claw arm 321 is used to abut against the tapered wall 3111 . The plurality of claw arms 321 can move in the radial direction to be retracted from each other. When the plurality of claw arms 321 are folded together, a fixing hole 324 is formed around the center of the plurality of claw arms 321 for accommodating the first wire 201 . The diameter of the fixing hole 324 is not larger than the diameter of the first wire 201. Therefore, when the plurality of claw arms 321 are folded together, the plurality of claw arms 321 can clamp the first wire 201 on the first wire 201. inside the fixing hole 324 . Referring to FIG. 3 , in some embodiments, the proximal end of the clamping sleeve 31 is provided with an internal thread, and the distal peripheral wall of the conducting member 210 is provided with a corresponding external thread. The outer thread of the distal end of the conducting member 210 is threadedly connected with the proximal end of the clamping sleeve 31 , so that the distal end of the conducting member 210 can extend into the receiving cavity 311 and abut the clamping jaw 32 .

Under the pressing action of the conducting member 210 , the base 320 of the clamping claw 32 moves to the distal side in the receiving cavity 311 , and drives the claw arm 321 to move toward the distal end relative to the clamping sleeve 31 . Since the cavity diameter of the distal end of the receiving cavity 311 of the clamping sleeve 31 gradually decreases in the direction from the proximal end to the distal end, the outer wall surface of each claw arm 321 is pressed by the tapered wall 3111 in the radial direction. The axes are close to each other, so that the plurality of claw arms 321 can be moved closer to each other, and the first lead wire 201 located between the plurality of claw arms 321 can be clamped. The other end of the first lead wire 201 is connected to the ablation component 20 to realize conduction The element 210 transmits ablation power to the ablation assembly 20 through the jaws 32 and the first wire 201 . The proximal end of the first wire 201 extends to the fixing hole 324 of the clamping jaw 32 and is located in the receiving cavity 311 of the clamping sleeve 31. After the conductive member 210 is separated from the conductive connecting member 30, the proximal end of the first wire 201 will not Emergence from the proximal end of the conductive connector 30 reduces the likelihood of device thrombosis.

Preferably, each claw arm 321 is an equally divided block with a frustum-shaped structure evenly divided along the circumferential direction. In this embodiment, the number of the claw arms 321 is three, and each claw arm 321 is divided into three equal parts in the shape of a truncated cone. It is understandable that the claw arms 321 may not be equally divided into blocks, as long as the plurality of claw arms 321 can be brought close to each other and together define a fixing hole 323 for clamping the first wire 201 .

Preferably, the base 320 is cylindrical. The axial distal end surface of the base 320 is used to abut the claw arm 321 , and the axial proximal end of the base 320 is used to receive the abutment of the conducting member 210 . It can be understood that the outer peripheral surface of the base 320 is preferably adapted to the inner wall of the proximal end of the clamping sleeve 31 . When the inner wall of the proximal end of the clamping sleeve 31 is a tapered surface, the base 320 is preferably in the shape of a truncated cone so as to be compatible with the clamping sleeve 31 . of the proximal inner wall.

Referring to FIGS. 3 and 4 , in this embodiment, a limiting portion 312 may be protruded on the inner wall of the clamping sleeve 31 , the limiting portion 312 is located at the proximal end of the inner wall of the receiving cavity 311 , and a hole is formed in the center of the limiting portion 312 313 , the hole diameter of the through hole 313 is smaller than the outer diameter of the clamping claw 32 , so that the clamping claw 32 can be restricted to move in the receiving cavity 311 through the limiting portion 312 . At the same time, the conducting member 210 can extend into the receiving cavity 311 through the through hole 313 and abut against the clamping jaw 32, thereby pushing the base 320 of the clamping jaw 32 to move to the distal side in the receiving cavity 311, and the base 320 drives the claw arm while moving. 321 moves to the distal end, because the circumferential outer surface of each claw arm 321 abuts against the conical inner wall of the clamping sleeve 31 , and then moves closer to each other to clamp the first lead 201 , so as to transmit ablation power to the ablation assembly 20 .

In this embodiment, the limiting portion 312 is annularly disposed on the inner side of the clamping sleeve 31 in a circumferential direction, and is used for limiting the clamping jaw 32 at the proximal end. In a modified embodiment, the limiting portion 312 includes at least one limiting sub-portion protruding on the inner surface of the clamping sleeve 31 for limiting the clamping jaw 32 at the proximal end of the clamping jaw 32 . In the case of sub-sections, the adjacent position-limiting sub-sections are spaced apart from each other, and the specific shape of each position-limiting sub-section is not limited.

Referring to FIGS. 3 to 5 , in this embodiment, the conducting member 210 includes a main body portion 2101 and a resisting portion 2102 protruding from the distal end of the main body portion 2101 . The portion 2102 protrudes beyond the distal end surface of the main body portion 2101 . The radial dimension of the abutting portion 2102 is smaller than that of the main body portion 2101 , so when the distal end of the main body portion 2101 is threadedly connected to the clamping sleeve 31 , the abutting portion 2102 can extend through the through hole 313 into the receiving cavity 311 and abut against the clamping jaw 32 The electrical connection between the two is realized, and the clamping jaws 32 are pushed to move to the distal side in the receiving cavity 311 , so that each claw arm 321 abuts against the inner wall of the clamping sleeve 31 , and is then reversely squeezed by the inner wall of the clamping sleeve 31 . , and then close to each other and clamp the first wire 201 .

FIGS. 7 and 8 are schematic views of another structure of the conductive connector 30 and the delivery device 200 . FIG. 7 shows the conductive connector 30 , and FIG. 8 shows a conveying device matched with the conductive connector 30 in FIG. 7 .

The delivery device 200 in this embodiment is similar in structure to the delivery device 200 in the embodiment in FIG. 2 , and can also be applied to the occlusion and ablation device 100 in the embodiment in FIG. 1 , but the structure of the conducting member 210 in this embodiment is different. In addition, the structure of the conductive connection member 30 of this embodiment is also different from that of the conductive connection member 30 in the embodiment of FIG. 2 . Specifically, the connection between the conveying device 200 and the conductive connector 30 in the embodiment of FIG. 2 is based on a screw connection, while the connection between the conveying device 200 and the conductive connector 30 in this embodiment is based on a card Buckle connection.

Please refer to FIG. 7 for details. In this embodiment, the conductive connecting member 30 is cylindrical and includes an annular side wall 304 . At least one snap hole 305 is formed on the annular side wall 304 . Preferably, there are multiple snap holes 305, and the multiple snap holes 305 are evenly spaced along the circumferential direction. Each snap hole 305 penetrates the annular sidewall 304 in the radial direction. Referring to FIG. 8 , in this embodiment, the conducting member 210 of the conveying device 200 includes a main body portion 2101 and at least one elastic piece 2103 disposed on the periphery of the main body portion 2101 . The main body portion 2101 is also cylindrical, and its outer diameter is slightly smaller than the The inner diameter of the conductive connector 30 . The at least one elastic piece 2103 is adapted to fit with the at least one snap hole 305 . The number of the elastic pieces 2103 is equal to that of the buckle holes 305 , and the circumferential positions of the elastic pieces 2103 are also in one-to-one correspondence with the circumferential positions of the buckle holes 305 .

The surface of at least one circumferential side of the elastic piece 2103 is arc-shaped. Specifically, the elastic piece 2103 is in the shape of an arc, which protrudes and extends outward relative to the outer surface of the main body portion 2101 . In this embodiment, both ends of the elastic sheet 2103 in the circumferential direction are connected to the main body portion 2101 , and the central portion in the circumferential direction protrudes outward along the radial direction of the main body portion 2101 , that is, the part between the two circumferential ends of the elastic sheet 2103 is away from the main body. The direction of the axis of the portion 2101 is convex. The elastic piece of this embodiment is preferably bent in a C shape. Preferably, the elastic piece 2103 may be integrally punched from the material of the wall of the main body portion 2101 , so the wall portion of the main body portion 2101 is formed with a punching hole corresponding to the position of the elastic piece 2103 .

When connecting, the main body 2101 of the conductive member 210 is inserted into the conductive connector 30 , and the elastic pieces 2103 of the conductive member 210 are clamped into the buckle holes 305 of the conductive connector 30 . In this way, the connection between the conductive member 210 and the conductive connector 30 is realized. Connection. Since the elastic piece 2103 is axially restricted in the snap hole 305, the distal movement of the conducting member 210 in the axial direction can drive the conductive connecting member 30 to move distally, so as to achieve the purpose of delivering the occlusion and ablation device.

When the conveying device 200 needs to be withdrawn, that is, when the conducting member 210 needs to be separated from the conductive connecting member, it is only necessary to rotate the conducting member 210 relative to the conducting connecting member 30 to deform the elastic piece 2103 and disengage the buckle hole 305. When the elastic piece 2103 After disengaging from the snap hole 305, the delivery device 200 can be removed in the axial direction. Specifically, in this embodiment, the rotation of the conductive member 210 relative to the conductive connection member 30 in a clockwise or counterclockwise direction can achieve separation between the conductive member 210 and the conductive connection member 30 .

In this embodiment, the connection and separation between the conducting member 210 and the conductive connecting member 30 are realized by the cooperation of the elastic sheet 2103 and the snap hole 305 , and the separation is realized by the relative rotation between the two. It can be understood that, in other modified embodiments, the positions of the elastic pieces and the snap holes can be interchanged, that is, the elastic pieces are arranged on the conductive connecting member 30 and the snap holes are arranged on the conductive member 210, and the above-mentioned transportation can also be realized by such arrangement. The purpose of occluding the ablation device and separating by relative rotation is achieved. After the snap hole 305 is assembled with the elastic piece 2103 , the annular side wall 304 around the snap hole 305 passes through the inner side of the elastic piece 2103 . The protruding direction facilitates the mutual snap fit between the snap hole 305 and the elastic piece 2103 .

Figures 8a-8c show another variation of the conductor 210 of the delivery device of Figure 8 . The conductive member 210 of this embodiment is also suitable for mating with the conductive connecting member 30 shown in FIG. 7 . This embodiment is similar to the conducting member 210 in the embodiment of FIG. 8 , and also includes a cylindrical body portion 2101 . The difference between this embodiment and the conducting member in the embodiment of FIG. 8 is that the shape of the elastic piece 2103 is different.

Specifically, in this embodiment, the elastic piece 2103 includes two convex portions 2103a and a concave portion 2103b connected between the two convex portions 2103a, and a concave portion 2103b is formed at the connection between the two convex portions 2103a. The two protruding parts 2103 a are arranged at intervals along the circumferential direction, and the protruding part 2103 a and the concave part 2103 b protrude in opposite directions along the radial direction of the main body part 2101 . The two convex portions 2103a are respectively located on both sides of the concave portion 2103b, and preferably, the two convex portions 2103a are symmetrically arranged. In this embodiment, each protruding portion 2103a is substantially U-shaped, its opening is toward the axis side of the main body portion 2101 , and the closed end away from the main body portion 2101 is arc-shaped. The adjacent arm portions (hereinafter defined as inner arm portions) of the two protruding portions 2103 a are connected to each other and are connected to each other near the radially inner side of the main body portion 2101 . The connection point of the two inner arm portions is located on the radially outer side of the radially outer surface of the main body portion 2101 , or is located on the radially inner side of the radially inner surface of the main body portion 2101 , or is parallel to the radially inner surface or the outer surface of the main body portion 2101 together. The arms of the two convex portions 2103a facing away from each other (hereinafter defined as the outer arm portions) are directly connected to the outer surface of the main body portion 2101, and extend in an arc shape in the direction away from the main body portion 2101. The outer arm is in the shape of a convex arc. In this embodiment, the elastic pieces 2103 as a whole form a roughly 3-shaped structure. In this embodiment, the two outer arm portions in the convex arc shape can abut against the hole walls on both sides of the buckle hole 305 in the circumferential direction. After the elastic piece 2103 enters the buckle hole 305 , the convex outer arm portion protrudes out from the buckle hole 305 , and the hole walls on both sides of the buckle hole 305 in the circumferential direction can just be caught between the elastic piece 2103 and the main body 2101 . The position is convenient for the alignment of the elastic piece 2103 with the snap hole 305; and when the occlusion and ablation device is not anchored to the wall of the left atrial appendage, the conductive connecting member 30 can rotate synchronously with the conducting member 210.

In addition, the arrangement of the recess 2103b facilitates the deformation of the elastic piece 2103 when subjected to force, especially the deformation in the radial direction, which facilitates the combination and disengagement of the elastic piece 2103 and the buckle hole 305 when the conducting member 210 and the conductive connecting member 30 rotate relative to each other.

It can be understood that, the two arm portions of the two convex portions 2103a facing away from each other may also be inwardly concave (protruding toward one side of the axis of the main body portion 2101 ) arc shape. In addition, the two convex portions of the elastic piece 2103 may also be asymmetrical structures, for example, the two convex portions have different curvatures, and those skilled in the art should understand that such deformations can also achieve the purpose of circumferential coupling and disengagement. In other modified embodiments, the elastic piece 2103 is provided with more than two convex portions 2103a, and a concave portion 2103b is provided between two adjacent convex portions 2103a.

Figures 8d-8f show another variation of the conductor 210 of Figures 8a-8c. The conductive member 210 of this embodiment is also suitable for mating with the conductive connecting member 30 shown in FIG. 7 . This embodiment is similar to the conducting member 210 in the embodiment of FIGS. 8a-8c, and also includes a cylindrical body portion 2101. As shown in FIG. The elastic piece 2103 includes two

convex portions

2103c, 2103d and a concave portion 2103e connected between the two

convex portions

2103c, 2103d. The two

convex portions

2103c and 2103d are respectively located on both sides of the concave portion 2103e , and the inner arms of the two

convex portions

2103c and 2103d are spaced apart from each other and connected at the radial inner side of the main body portion 2101 . The connection point of the two inner arm portions is located on the radially outer side of the radially outer surface of the main body portion 2101 , or is located on the radially inner side of the radially inner surface of the main body portion 2101 , or is parallel to the radially inner surface or the outer surface of the main body portion 2101 together. The outer arm portions of the two

convex portions

2103c and 2103d are both directly connected to the outer surface of the main body portion 2101 .

The difference between this embodiment and the conducting member of the embodiment shown in FIGS. 8a-8c is that the shapes of the two

protrusions

2103c and 2103d of the elastic sheet 2103 are different.

Specifically, in this embodiment, the two protruding

portions

2103c and 2103d include a first protruding portion 2103c and a second protruding portion 2103d. The outer arm portion of the first protruding portion 2103c has an arc shape, and the outer arm portion of the second protruding portion 2103d has a flat shape. The side of the outer arm portion of the second convex portion 2103d away from the first convex portion 2103 is a flat surface. In other words, one side of the elastic piece 2103 in the circumferential direction is formed as a convex arc surface, and the other side is formed as a flat surface. Preferably, the two arm portions of the first convex portion 2103c and the inner arm portion of the second convex portion 2103d both extend obliquely in the same direction, as shown in the figure, both extend in a clockwise direction.

In this embodiment, the first protruding portion 2103c is in the shape of a ratchet, and one end of the first protruding portion 2103c away from the outer surface of the main body portion 2101 forms a tine structure. The second protruding portion 2103d is in an inverted V shape, its open end faces the axis side of the main body portion 2101 , and the closed end away from the radially outer surface of the main body 2101 forms a tine structure. In a modified embodiment, the outer arm portion of the second convex portion 2103d is arc-shaped (eg, extending from the surface of the main body portion 2101 in a clockwise or counterclockwise direction away from the axis of the main body portion 2101 ). In a modified embodiment, the inner arm portion of the second protruding portion 2103d may be arc-shaped, such as protruding in a direction away from the axis of the main body 2101 , that is, outwardly protruding, or protruding in a direction close to the axis of the main body 2101 , i.e., inwardly concave . In this embodiment, in addition, after projecting the conducting member 210 in the axial direction along the radial direction, the projection of the elastic piece 2103 is entirely located within the range of the buckle hole 305 .

In this embodiment, the circumferential side of the elastic piece 2103 is a plane, which can prevent the elastic piece 2103 from rotating and disengaging in a clockwise direction relative to the buckle hole 305, but can only be disengaged in a counterclockwise direction, which improves the connection safety. In addition, the side surface is set as a plane, so that after projecting along the radial direction to the axial direction, the projection of the elastic piece 2103 falls into the range of the buckle hole 305, so that after the elastic piece 2103 is radially compressed, the elastic piece can be deformed toward the buckle hole, which is The elastic pieces 2103 provide more deformation space to prevent the compressed elastic pieces 2103 from interfering with the circumferential hole wall of the buckle hole 305 during the separation process of the conductive connecting member 30 and the conducting member 210 , so that the separation is smoother.

In the figure, each elastic piece 2103 is formed with two sharp corners on the circumferential edge, which is convenient for compression and expansion in the radial direction, and facilitates the release and combination of the elastic piece 2103 and the buckle hole 305 . In the modified embodiment, the circumferential edge of the elastic piece 2103 is an arc structure.

Among the four arms of the elastic piece 2103 , except for the planar arms, the other three arms have the same inclination direction, specifically extending clockwise from the main body 2101 and protruding away from the main body 2101 , which is convenient for the conducting member 210 When the conductive connector 30 rotates relative to the circumferential direction, the elastic piece 2103 is released from the buckle hole 305 .

In the modified embodiment, the elastic piece 2103 is provided with a convex portion, and the convex portion is provided with the outer arm portion of the first convex portion 2103c and the outer arm portion of the second convex portion 2103d in this embodiment.

Figures 9-11 illustrate another variation of the conductor 210 of the delivery device of Figure 8 . FIG. 21 is a schematic diagram of the assembled first conductive member 210 and the conductive connecting member 30 . The conductive member 210 of this embodiment is also suitable for mating with the conductive connecting member 30 shown in FIG. 7 . This embodiment is similar to the conducting member 210 in the embodiment of FIG. 8 , and also includes a cylindrical body portion 2101 . The difference between this embodiment and the conducting member of the embodiment in FIG. 8 is that in this embodiment, a pawl 2104 is used to replace the elastic piece 2103 in FIG. The pawl 2104 is an elastic member, which can be elastically deformed when subjected to force.

Specifically, the number and position of the pawls 2104 also correspond to the snap holes 305 . The pawls 2104 are generally wedge-shaped blocks, and are arranged protruding from the annular outer surface of the main body portion 2101 . In some embodiments, the pawls 2104 are protruding from the annular inner surface of the main body portion 2101 and are arranged along the circumferential direction of the main body portion 2101 . , the thickness of the pawl 2104 (ie the dimension along the radial direction of the main body portion 2101 ) gradually increases from the first side (left side in the figure) to the second side (right side in the figure) in the circumferential direction. Preferably, the minimum thickness of the pawl 2104 is 0, that is, two sides in the circumferential direction of the radially outer surface thereof are respectively provided with a side surface, and both side surfaces are connected with the main body portion 2101 . The first side of the radially outer surface of the pawl 2104 is directly connected to the outer surface of the main body portion 2101 . More preferably, the first side of the radial surface of the pawl 2104 is tangent to the surface of the body portion 2101 , and in this embodiment, the first side of the radially outer surface of the pawl 2104 is tangent to the outer surface of the body portion 2101 . The second side of the radially outer surface of the pawl 2104 is connected to the outer surface of the main body portion 2101 through a limiting surface 2105 . Preferably, the limiting surface 2105 protrudes and extends from the outer surface of the body portion 2101 toward the radially outer side of the body portion 2101 .

When connecting, the main body 2101 of the conductive member 210 is inserted into the conductive connector 30 , and the pawl 2104 of the conductive member 210 is clamped into the buckle hole 305 of the conductive connector 30 . In this way, the connection between the conductive member 210 and the conductive connector 30 is realized. connection between. If the position of the pawl 2104 is not aligned with the buckle hole 305 when the conductive member 210 is inserted, it is only necessary to rotate the conductive member 210 clockwise in FIG. 10 . The pawl 2104 can be snapped into the snap hole 305 to realize the connection between the conductive member 210 and the conductive connection member 30 . Since the pawl 2104 is axially limited in the snap hole 305 , the distal movement of the conducting member 210 in the axial direction can drive the conductive connecting member 30 to move distally, so as to achieve the purpose of delivering the occlusion and ablation device.

When the conveying device needs to be withdrawn, that is, when the conducting member 210 needs to be separated from the conductive connecting member 30, it is only necessary to rotate the conducting member 210 clockwise relative to the conducting connecting member 30 to make the pawl 2104 disengage from the buckle hole 305, After the pawl 2104 is disengaged from the locking hole 305, the conveying device can be removed in the axial direction. In this embodiment, the first side of the radially outer surface of the pawl 2104 is tangent to the outer surface of the main body portion 2101 , which facilitates the separation of the pawl 2104 from the buckle hole 305 more smoothly, thereby facilitating the conducting member 210 Separation from conductive connections 30 .

In this embodiment, the connection and separation between the conducting member 210 and the conductive connecting member 30 are realized through the cooperation of the ratchet pawl 2104 and the snap hole 305 , and the separation is realized by the relative rotation between the two. It can be understood that in other modified embodiments, the positions of the pawl and the snap hole can be interchanged, that is, the pawl is provided on the conductive connecting member 30, and the snap hole is provided on the conductive member 210, and this arrangement can also achieve The above-mentioned delivery of the occlusion ablation device and the relative rotation achieve the purpose of separation.

12 to 15 are still another structural schematic diagrams of the conductive connecting member 30 and the conducting member 210 . 12 and 13 show the conductive connector 30 . FIG. 14 shows a conductive member 210 matched with the conductive connector 30 in FIG. 12 . FIG. 15 is an assembly view of the conductive connecting member 30 of FIG. 12 and the conductive member 210 of FIG. 14 .

The conductive member 210 and the conductive connection member 30 in this embodiment are similar in structure to the conductive member 210 and the conductive connection member 30 in the embodiment of FIGS. 7 and 8 . The difference is that in this embodiment, the protrusion 2106 and the buckle groove 306 are matched with each other, and the protrusion 2106 can slide along the buckle groove 306 .

Please refer to FIGS. 12 and 13 for details. In this embodiment, the conductive connecting member 30 is also cylindrical and includes an annular side wall 304 . At least one snap groove 306 is formed on the annular side wall 304 . Preferably, there are a plurality of snap grooves 306, and the plurality of snap grooves 306 are evenly spaced along the circumferential direction. Each snap groove 306 penetrates the annular sidewall 304 in the radial direction.

Specifically, please refer to FIG. 13 , for the sake of clarity, only one of the latching grooves 306 is shown in the figure, and the visible structure of the other latching groove 306 is omitted. The snap groove 306 includes an inlet section 3061, a limit section 3062, and a connection section 3063 connected between the inlet section and the limit section.

The inlet section 3061 penetrates the axial proximal end face of the annular side wall 304 of the conductive connector 30 and extends toward the other axial end (distal end), and may extend axially along the annular side wall 304, or relative to the axial direction of the annular side wall 304 The axial oblique extension.

The limiting section 3062 extends between the two axial ends of the annular side wall 304 of the conductive connector 30 , and may extend along the axial direction of the annular side wall 304 , or extend obliquely relative to the axial direction of the annular side wall 304 .

The connecting section 3063 is disposed away from the proximal and distal surfaces of the annular side wall 304 of the conductive electrical connector 30 , the connecting section 3063 extends along the circumferential direction of the conductive connector 30 , and one end of the connecting section 3063 is connected to the annular side wall of the inlet section 3061 away from the annular One end of the proximal end surface of 304 is connected to one end (proximal end or distal end) of the limiting segment 3062 at the other end of the connecting segment 3063 .

The inlet section 3061 extends from the proximal end face of the annular side wall 304 toward the distal end to the middle of the annular side wall 304 , and the inlet section 3061 penetrates through the proximal end face of the annular side wall 304 to form an opening. The connecting section 3063 extends circumferentially from the distal end of the inlet section 3061 . The limiting segment 3063 extends from one end of the connecting segment 3063 away from the inlet segment 3061 toward the proximal end. One end of the limiting section 3062 away from the connecting section 3063 is located in the middle of the annular side wall 304 , that is, it does not penetrate through the bottom end face of the annular side wall 304 . In this embodiment, the inlet section 3061 extends in the axial direction, and the connecting section 3063 extends in the circumferential direction. The limiting section 3062 extends in the axial direction. Both the limiting section 3062 and the inlet section 3061 are located at the proximal end side of the connecting section 3063 , and the length of the limiting section 3062 is smaller than the length of the inlet section 3061 . Specifically, as shown in FIG. 12 , the snap groove 306 is substantially J-shaped. In other embodiments, the limiting segment 3062 is located on the distal side of the connecting segment 3063 .

Referring to FIG. 14 , the conducting member 210 includes a main body portion 2101 and at least one protrusion 2106 disposed on the periphery of the main body portion 2101 , and the main body portion 2101 is cylindrical. Its outer diameter is slightly smaller than the inner diameter of the conductive connecting piece 30 . The at least one protrusion 2106 is adapted to fit with the at least one snap groove 306 . The number of the protrusions 2106 is equal to the number of the locking grooves 306 , and the circumferential positions of the protrusions 2106 also correspond one-to-one with the circumferential positions of the locking grooves 306 . Specifically, in this embodiment, the protrusion 2106 is cylindrical, and its outer diameter is slightly smaller than the width of the buckle groove 306 , and the width of the buckle groove 306 is a dimension perpendicular to its extending direction.

15, when connecting, align the conductive member 210 with the conductive connector 30 in the axial direction, wherein the protrusion 2106 is aligned with the inlet section 3061 of the snap groove 306, and push the conductive member 210 toward the distal end in the axial direction, the conductive member The main body portion 2101 of the 210 is inserted into the conductive connector 30, the protrusion 2106 enters from the opening of the inlet section 3061, and slides along the inlet section 3061 with the further displacement of the conductive member 210 towards the distal end until it reaches the other end of the inlet section 3061, At this time, the conducting member 210 is rotated in the circumferential direction. In this embodiment, the conducting member 210 is rotated counterclockwise, so that the protrusion 2106 slides along the connecting section 3063 until the protrusion 2106 reaches the end of the connecting section 3063 away from the inlet section 3061. , and then the conducting member 210 is further retracted toward the proximal end, and the protrusion 2106 enters the limiting section 3062 . Limiting segment 3062 limits circumferential movement of protrusion 2106 . Therefore, at this time, the relative movement in the circumferential direction between the conducting member 210 and the conductive connecting member 30 is prevented, but at this time, the movement of the conducting member 210 toward the distal end can drive the conductive connecting member to move together, so that the occlusion and ablation device can also be delivered. the goal of.

When the delivery device needs to be withdrawn, that is, the conducting member 210 needs to be separated from the conductive connecting member 30, it is only necessary to push the conducting member 210 to the distal side in the axial direction, so that the protrusion 2106 of the conducting member 210 is slid to align with the connecting section 3063 , and then turn the conducting member 210 clockwise to make the protrusion 2106 slide along the connecting section 3063 until it is aligned with the inlet section 3061. At this time, pull the conducting member 210 in the axial direction to the proximal side, so that the conducting member 210 can be connected with the conductive member 210. Separation of the connector 30 .

In this embodiment, the connection and separation between the conducting member 210 and the conductive connecting member 30 are realized by the cooperation of the protrusion 2106 and the snap groove 306 , and the separation is realized by relative rotation in the circumferential direction between the two. It can be understood that, in other modified embodiments, the positions of the protrusions and the snap grooves can be interchanged, that is, the protrusions are provided on the conductive connecting member 30, and the snap grooves are provided on the conductive member 210, and this arrangement can also achieve the above purpose. In the embodiment in which the snap groove is provided in the conducting member 210 , the inlet section 3061 penetrates the axial distal end surface of the conducting member 210 and extends toward the other end (proximal end) in the axial direction, and the limiting section 3062 is located at two axial directions of the conducting member 210 . extending between the ends, the connecting section 3063 is disposed away from the axial end face of the conducting member 210, the connecting section 3063 extends in the circumferential direction, one end of the connecting section 3063 is connected to the end of the inlet section 3061 that is far away from the conducting member 210, and the other end of the connecting section 3063 is connected One end of the limiting section 3062 .

In the above embodiments of FIGS. 7-8, 8a-8c, 8d-8f, 9-11, and 12-15, if the conductive connecting member 30 is made of conductive material, the mechanical connection and the electrical connection can be simultaneously realized through the above-mentioned snap connection . In some embodiments, the conductive connection member 30 may also be a non-conductive material. In this case, the conductive connection member 30 of each of the above embodiments may be configured to include the jaws in the embodiment of FIG. The distal end of the main body portion 2101 of the member 210 is provided with a resisting portion. That is, in the embodiment of FIG. 3, the threaded connection structure between the clamping sleeve 31 and the conducting member 210 is replaced with any one of FIGS. 7-8, 8a-8c, 8d-8f, 9-11, and 12-15 The snap-fit connection structure of the embodiment.

For the second embodiment, refer to the structure shown in FIG. 16 .

Please refer to FIG. 16 , in conjunction with FIG. 1 , the structure of the left atrial appendage occlusion and ablation system of the present embodiment is similar to that of the left atrial appendage occlusion and ablation system of the embodiment of FIG. Closed, distally open cup-like structure. The main difference between this embodiment and the occlusion and ablation device 100 in the embodiment of FIG. 1 is that the manufacturing process of the support frame 10 is different.

In this embodiment, the support frame 10 is woven to form a grid-like frame structure by a weaving process. More specifically, the side wall of the support frame 10 in this embodiment is a straight cylinder. In the embodiment of FIG. 1 , the side wall of the support frame 10 is an arc surface, and the radial dimensions at different axial positions are different. However, between the occlusion and ablation device 100 and the delivery device 200 in this embodiment, the screw connection between the delivery device 200 and the conductive connector 30 in the embodiment of FIG. In the example, the clamping claw connection between the conveying device 200 and the conductive connecting member 30 realizes the circumferential rotation disengagement. The snap-fit connection structure of any one of the embodiments in Figs. 7-8, 8a-8c, 8d-8f, 9-11, and 12-15 can also be used to realize the circumferential rotation disengagement. Therefore, in the manner of each embodiment in this application, the manufacturing process of the embodiment is not limited.

For the third embodiment, refer to the structure shown in FIG. 17 .

Please refer to FIG. 17 , in conjunction with FIG. 16 , the structure of the left atrial appendage occlusion and ablation system of the present embodiment is similar to that of the left atrial appendage occlusion and ablation system of the embodiment of FIG. The main difference between the occlusion and ablation device of this embodiment and the occlusion and ablation device 100 of the embodiment of FIG. 16 is that the structure of the support frame 10 is slightly different.

In this embodiment, both the proximal end and the distal end of the support frame 10 are closed cage structures. The conductive connector 30 is disposed on the proximal surface of the support frame 10 . The center of the distal surface of the support frame 10 is further provided with a distal connector 111 , and the distal connector 111 is accommodated inside the support frame 10 .

It should be noted that, between the occlusion and ablation device 100 and the delivery device 200 in this embodiment, the screw connection in the embodiment of FIG. 2 , the claw connection in the embodiment of FIG. 8c, 8d-8f, 9-11, and 12-15 any one of the embodiments of the snap-fit connection structure to achieve circumferential rotation disengagement.

It can be understood that, in some other embodiments, the conductive connector 30 may also be provided on the distal surface of the support frame 10 . At this time, the proximal end surface of the support frame 10 is provided with a proximal end connecting piece, and the delivery device 200 passes through the proximal end connecting piece, and then rotates and disengages from the conductive connecting piece 30 in the circumferential direction.

For the fourth embodiment, refer to the structure shown in FIG. 18 .

Please refer to FIG. 18 , in conjunction with FIG. 17 , the structure of the left atrial appendage occlusion and ablation system of the present embodiment is similar to that of the left atrial appendage occlusion and ablation system of the embodiment of FIG. same. The main difference between the occlusion and ablation device of this embodiment and the occlusion and ablation device 100 of the embodiment in FIG. 17 is that the structure of the support frame 10 is different.

In this embodiment, the support frame 10 adopts a double-disc grid-like frame structure formed by weaving. The support frame 10 includes a sealing portion 11 at the proximal end for closing the opening of the left atrial appendage and an anchoring portion 12 at the distal end for anchoring to the inner wall of the left atrial appendage. Both the sealing part 11 and the anchoring part 12 are in the shape of a mesh disk.

In this embodiment, the sealing portion 11 is a double-layer mesh disk structure formed by a weaving process. That is, the mesh disk structure of the sealing portion 11 includes a disk surface located on the proximal side and a disk surface located on the distal side. In this embodiment, the sealing portion 11 and the anchoring portion 12 are both made of conductive materials, such as nickel-titanium braided wire. After the sealing portion 11 and the anchoring portion 12 are braided and shaped respectively, they are connected together through the skeleton connector 130 . , at least part of the skeleton connecting member 130 is made of insulating material, so as to prevent the sealing part 11 and the anchoring part 12 from conducting electricity with each other. In some embodiments, when the sealing portion 11 and the anchoring portion 12 do not need to be insulated from each other, for example, when at least one of the two is made of insulating material, the skeleton connecting member 130 may have conductive properties, For example, it is made of metal material, which will not destroy the insulating properties between the two discs.

It should be noted that, in some embodiments, both the sealing portion 11 and the anchoring portion 12 can be obtained by a weaving process or a cutting process.

In this embodiment, the ablation assembly 20 may be disposed on the sealing portion 11 or may be disposed on the anchoring portion 12 . The ablation assembly 20 may be an ablation electrode additionally disposed on the sealing part 11 or the anchoring part 12 , or a part of the skeleton in the sealing part 11 or the anchoring part 12 may be used as the ablation assembly 20 . It can be understood that, as the skeleton of the ablation assembly 20 and the ablation electrode, the first wire can be used for power transmission.

The sealing part 11 and the anchoring part 12 can be made of the same material or different materials. In the case where the sealing part 11 and the anchoring part 12 are both made of conductive materials, in order to avoid electrical connection between the two, the skeleton connector 130 may be an insulating connector, that is, at least part of the skeleton connector 130 is made of insulating material production.

In this embodiment, the conductive connecting member 30 is disposed at the center of the proximal end surface of the sealing portion 11 . In some embodiments, the conductive connector 30 can also be provided on the distal surface of the sealing part 11 , or on the proximal end or the distal end of the anchoring part 12 .

It should be noted that the threaded structure in the embodiment of FIG. 2, the claw-type structure in the embodiment of FIG. 3, or the threaded structure in the embodiment of FIG. 8c, 8d-8f, 9-11, and 12-15 any one of the embodiments of the snap-fit connection structure to achieve circumferential rotation disengagement.

Specifically, the sealing portion 11 is in the shape of a plug, and the sealing portion 11 includes a proximal disk surface, a distal disk surface, and an intermediate portion connected between the proximal disk surface and the distal disk surface. The proximal disk is used for connecting the conductive connector 30 , and the distal disk is used for connecting with the skeleton connector 130 . The space occupied by the sealing portion 11 in the axial direction is relatively large, which is convenient for the sealing portion 11 to block the mouth of the left atrial appendage. The blocking membrane is disposed on the inner side and/or the outer side of the proximal disk surface of the sealing portion 11 , and is used to block the thrombus inside the left atrial appendage from flowing out of the left atrial appendage orifice to the left atrium.

The proximal disk surface of the anchoring portion 12 is used to connect the skeleton connecting member 130, and the center of the proximal disk surface of the anchoring portion 12 is connected to the skeleton connecting member 130. The main body of the anchoring portion 12 is a folded structure. Specifically, the anchoring portion 12 includes The inner support wall 125 , the outer support wall 126 and the inner curved wall 127 are connected in sequence. The inner support wall 125 , the outer support wall 126 and the inner curved wall 127 are all mesh structures obtained by weaving braided wires, all of which are formed with mesh holes, and the three can be integrally woven.

The inner support wall 125 extends along the proximal end and the distal end. The radial dimension of the inner support wall 125 increases gradually from the proximal end to the distal end, is trumpet-shaped, and forms a bell mouth at the distal end. The outer support wall 126 extends between the proximal end and the distal end, and the outer support wall 126 is disposed radially outside the inner support wall 125 for abutting against and being fixed on the tissue surface of the inner wall of the left atrial appendage. The proximal end of the outer support wall 126 is connected to the proximal end of the inner curved wall 127, the inner curved wall 127 extends obliquely between the proximal end and the distal end, and the distal end of the inner curved wall 127 is distant from the center of the anchor portion 12 relative to its proximal end The axis is closer. The inwardly curved wall 127 is disposed in the inner cavity enclosed between the inner support wall 125 and the outer support wall 126 to prevent the proximal end of the outer support wall 126 from damaging the tissue.

For the fifth embodiment, refer to the structure shown in FIG. 19 .

Please refer to FIG. 19 , and in conjunction with FIG. 17 , the structure of the left atrial appendage occlusion and ablation system of the present embodiment is similar to that of the left atrial appendage occlusion and ablation system of the embodiment of FIG. 17 . Both the proximal and distal ends are closed structures. The main difference between the left atrial appendage occlusion and ablation system of this embodiment and the embodiment of FIG. 17 is that the arrangement position of the conductive connection member 30 is different, and the delivery device 200 is different.

In this embodiment, the ablation assembly 20 may be an ablation electrode additionally disposed on the support frame 10 , or a part of the support frame 10 may be directly used as the ablation assembly 20 . The ablation electrode and the conductive connector 30 may be electrically connected by wires. The ablation assembly 20 is positioned proximate the distal end of the support frame 10 .

The distal end of the support frame 10 is provided with a distal connector, and the proximal end is provided with a proximal connector 112 . The distal connector serves as the conductive connector 30 , and the proximal connector is used to achieve a mechanical connection with the delivery device 200 . In this embodiment, the delivery device 200 includes an inner tube 220 and an outer tube 230 arranged inside and outside, and the inner tube 220 is movably passed through a channel in the outer tube 230 . Preferably, the inner tube 220 and the outer tube 230 are arranged coaxially. The outer tube 230 is set as a non-conductive structure, and the distal end of the outer tube 230 is detachably connected to the proximal connector of the support frame 10. The connection method is not limited, and the threaded connection method in the embodiment of FIG. - The snap-fit connection structure of any one of the embodiments of 8c, 8d-8f, 9-11, and 12-15. The inner tube 220 is set as a conductive structure, the inner tube 220 is used as the conducting member 210 , and the distal end of the inner tube 220 is electrically connected to the conductive connecting member 30 of the support frame 10 . Between the conductive connector 30 and the distal end of the inner tube 220, the screw-type structure of the embodiment of FIG. 2, the claw-type structure of the embodiment of FIG. 3, or the threaded structure of the embodiment of FIG. 11, and the snap-fit connection structure of any one of the embodiments of 12-15 to achieve circumferential rotation disengagement.

In some embodiments, the distal connector includes a proximal piece and a distal piece. Wherein, the proximal part is insulated, and the distal part is conductive. The proximal end piece is used to bundle the distal end of the skeleton connected to the anchoring portion 12, and the distal end piece is used to conduct conductive connection with the inner tube 220, so as to facilitate the insulation between the ablation electrode and the support skeleton 10, and the support skeleton 10 can be connected to the ablation electrode. They are insulated from each other, for example, the parts that are in contact with each other are insulated.

For the sixth embodiment, refer to the structure shown in FIG. 20 .

Please refer to FIG. 20 , in conjunction with FIG. 19 , the structure of the left atrial appendage occlusion and ablation system of the present embodiment is similar to that of the left atrial appendage occlusion and ablation system of the embodiment of FIG. 19 . 200 includes an inner and outer casing arrangement, preferably an inner tube 220 and an outer tube 230 arranged coaxially. The main difference between this embodiment and the embodiment of FIG. 19 is that the manufacturing process of the support frame 10 is different.

In this embodiment, the support frame 10 adopts a grid-like frame structure which is integrally cut. The conductive connector 30 is arranged at the center of the distal surface of the support frame 10 as a distal connector of the support frame 10 .

The outer tube 230 is set as a non-conductive structure, and the distal end of the outer tube 230 is detachably connected to the proximal connector of the support frame 10, and the connection method is not limited. The inner tube 220 is set as a conductive structure, the inner tube 220 is used as the conducting member 210 , the distal end of the inner tube 220 is electrically connected with the conductive connecting member 30 at the distal end of the support frame 10 , and the conductive connecting member 30 is accommodated on the distal surface of the supporting frame 10 . near side. Between the conductive connector 30 and the distal end of the inner tube 220, the screw-type structure of the embodiment of FIG. 2, the claw-type structure of the embodiment of FIG. 3 or the claw-type structure of the embodiment of FIG. 11, and the snap-fit connection structure of any one of the embodiments of 12-15 to achieve circumferential rotation disengagement.

It should be noted that, in this embodiment, the ablation assembly 20 may be an ablation electrode additionally disposed on the support frame 10 , or a part of the frame in the support frame 10 may be used as the ablation assembly 20 . The ablation electrode and the conductive connector 30 may be electrically connected by wires.

In this embodiment, the radial dimension of the sealing portion is larger than that of the anchoring portion, which facilitates the sealing of the sealing portion at the opening of the left atrial appendage and improves the sealing performance of the sealing portion.

For the seventh embodiment, please refer to the structures of FIGS. 21 and 22 .

FIG. 21 is a schematic structural diagram of a left atrial appendage occlusion and ablation system provided by the seventh embodiment of the present invention. FIG. 22 is a schematic structural diagram of the conveying device 200 in FIG. 21 .

Please refer to FIGS. 21 and 22 , and in conjunction with FIG. 19 , the structure of the left atrial appendage occlusion and ablation system of the present embodiment is similar to that of the left atrial appendage occlusion and ablation system of the embodiment of FIG. 19 . Outer casing arrangement, preferably inner tube 220 and outer tube 230 arranged coaxially. The main difference between this embodiment and the embodiment of FIG. 19 lies in the structure of the support frame 10 .

The sealing portion 11 is in the shape of a double-layer mesh disk, and in some embodiments, the sealing portion 11 may also be in the shape of a single-layer mesh disk. The anchoring portion 12 is in the shape of a plunger, and the ablation component 20 is a series of point electrodes disposed on the anchoring portion 12 .

A frame connecting piece is arranged between the sealing part 11 and the anchoring part 12 , and the frame connecting piece is tubular, and a channel is arranged in the middle.

In this embodiment, the conductive connecting member 30 is disposed at the center of the distal end of the anchoring portion 12 . The conductive connecting member 30 can adopt the screw-type structure of the embodiment of FIG. 2 or the claw-type structure of the embodiment of FIG. 3 to realize the circumferential rotation disengagement from the distal end of the inner tube 220 .

The outer tube 230 is set as a non-conductive structure, and the distal end of the outer tube 230 is detachably connected to the proximal connector of the support frame 10, and the connection method is not limited. The inner tube 220 is set as a conductive structure, the inner tube 220 is used as the conducting member 210, the distal end of the inner tube 220 passes through the connecting member between the sealing part 11 and the anchoring part 12, and the conductive connecting member 30 is electrically connected, and the conductive connecting member 30 is accommodated in the support frame 10 and is located at the proximal side of the distal end surface of the support frame 10 .

In this embodiment, the ablation assembly 20 is disposed on the anchoring portion 12 , and in a modified embodiment, the ablation assembly can also be disposed on the sealing portion 11 . The ablation assembly 20 may be an ablation electrode additionally disposed on the sealing part 11 or the anchoring part 12 , or a part of the skeleton in the sealing part 11 or the anchoring part 12 may be used as the ablation assembly 20 .

Referring to FIG. 22 , in this embodiment, the conveying device 200 includes an inner tube 220 and an outer tube 230 arranged inside and outside. The outer tube 230 is configured as a non-conductive structure, and the inner tube 220 is configured as a conductive structure. The inner tube 220 serves as the conducting member 210 for electrical connection with the conductive connecting member 30 . The structure between the inner tube 220 and the conductive connector 30 may adopt the threaded structure in the embodiment of FIG. 2 , the claw structure in the embodiment of FIG. 3 , or the structure shown in FIGS. 7-8 , 8a-8c, 8d - The snap-fit connection structure of any one of the embodiments of 8f, 9-11, and 12-15.

It should be noted that the conveying device 200 of the present embodiment is also applicable to the respective embodiments of FIG. 19 and FIG. 20 , unless there is a contradiction.

For the eighth embodiment, please refer to the structures of FIGS. 23 and 24 .

23 is a schematic structural diagram of a left atrial appendage occlusion and ablation system according to an eighth embodiment of the present invention. FIG. 24 is a schematic structural diagram of the conveying device 200 and the conductive connector 30 in FIG. 23 .

Please refer to FIGS. 23 and 24 , and in conjunction with FIG. 1 , the left atrial appendage occlusion and ablation system of this embodiment is similar in structure to the left atrial appendage occlusion and ablation system of the embodiment of FIG. 1 , and the occlusion and ablation device 100 is basically the same. The main difference between the occlusion and ablation device of this embodiment and the occlusion and ablation device 100 of the embodiment of FIG. 1 is that the number of ablation components is different.

In this embodiment, the ablation assembly includes a first ablation member 21 and a second ablation member 22 . The first ablation member 21 and the second ablation member 22 are provided on the support frame 10 in a mutually insulated manner.

The first ablation member 21 and the second ablation member 22 are used to electrically connect with the delivery device 200 through the conductive connection member 30 respectively, so as to transmit two same or different ablation energies, or can also be used for electrophysiological signal mapping. For example, in one period, both the first ablation element 21 and the second ablation element 22 are used for ablation, and in another period, both the first ablation element 21 and the second ablation element 22 are used for mapping, or part of the ablation assembly 20 is always used for ablation, and partial ablation assembly 20 is always used for mapping.

The first ablation member 21 may be an ablation electrode additionally disposed on the support frame 10 , or may be at least part of the frame structure of the support frame 10 . The second ablation member 22 may be an ablation electrode additionally disposed on the support frame 10 , or may be at least part of the frame structure of the support frame 10 .

Referring to FIG. 23 , in this embodiment, the first ablation member 21 is a partial skeleton structure supporting the sealing portion 11 in the skeleton 10 . The second ablation member 22 is an ablation electrode additionally disposed on the support frame 10 , and the second ablation member 22 is connected to the conductive connection member 30 through the second wire 202 .

It can be understood that, in some embodiments, the first ablation member 21 may also be a partial skeleton structure supporting the anchoring portion 12 in the skeleton 10 .

It should be noted that, in some other embodiments, the first ablation member 21 may also be an ablation electrode disposed on the support frame 10 , and the second ablation member 22 may also adopt a partial frame structure of the support frame 10 .

Referring to FIG. 24 , in this embodiment, the conductive connecting member 30 can be formed in one piece. The conductive connector 30 includes a first conductive portion 301 and a second conductive portion 302 that are insulated and connected to each other and integrally formed. The first conductive portion 301 and the second conductive portion 302 are respectively electrically connected to the delivery device 200, and further can be used to transmit two same or different ablation energies, or can also be used for electrophysiological signal mapping.

Referring to FIGS. 23 and 24 , the first conductive portion 301 and the second conductive portion 302 are arranged to be insulated from each other, and the first conductive portion 301 is used for electrical connection with the first ablation member 21 to transmit ablation energy to the first ablation member 21 . The second conductive portion 302 is used for electrical connection with the second ablation member 22 to transmit ablation energy to the second ablation member 22 . The first conductive portion 301 and the second conductive portion 302 cooperate to transmit two same or different ablation energies to the first ablation member 21 and the second ablation member 22, and after the ablation is completed, the first conductive portion 301 and the delivery Circumferential rotation and separation are performed between the devices 200 and between the second conductive portion 302 and the conveying device 200, respectively. It should be noted that different ablation energies may refer to ablation energies with different parameters, such as different polarities.

Referring to FIG. 24 , in this embodiment, the conducting member 210 of the conveying device 200 includes a first conducting portion 211 and a second conducting portion 212 , and the first conducting portion 211 and the second conducting portion 212 are insulated from each other.

Referring to FIG. 24 , in this embodiment, the first conductive portion 301 and the second conductive portion 302 are both tubular structures. Both the first conductive portion 301 and the second conductive portion 302 are provided with internal thread structures. Meanwhile, the outer peripheries of the first conducting portion 211 and the second conducting portion 212 are both provided with external threads. The first conducting portion 211 is provided on the proximal side of the second conducting portion 212 . The first conductive portion 211 is screwed and electrically connected to the first conductive portion 301 , thereby realizing the circumferential rotational connection and electrical connection between the first conductive portion 211 and the first conductive portion 301 . The second conductive portion 212 is screwed and electrically connected to the second conductive portion 302 , thereby realizing the circumferential rotational connection and electrical connection between the second conductive portion 212 and the second conductive portion 302 . Therefore, the ablation energy can be transmitted to the first conductive part 301 and the second conductive part 302 and then to the first ablation element 21 and the second ablation element 22 through the first conductive part 211 and the second conductive part 212 independently of each other.

Referring to FIG. 24 , in this embodiment, the first conducting portion 211 and the second conducting portion 212 of the conducting member 210 are tubular structures that are insulated from each other and integrally formed. The first conducting portion 211 and the second conducting portion 212 are both disposed at the distal end of the delivery device 200 , and the first conducting portion 211 is located on the proximal side of the second conducting portion 212 .

In the present embodiment, the first conductive portion 301 is provided on the proximal side of the second conductive portion 302 and is spaced apart from the second conductive portion 302 in the axial direction. An insulating section 303 is provided between the first conductive portion 301 and the second conductive portion 302 , so that the first conductive portion 301 and the second conductive portion 302 are connected in isolation. For example, the conductive metal material and the insulating material are connected together by means of melting, bonding, clipping, etc. to form the first conductive portion 301 , the insulating section 303 and the second conductive portion 302 in an integrated structure.

It should be noted that, in some embodiments, the first conductive portion 301 and the second conductive portion 302 may also be arranged at intervals in the circumferential direction. For example, the first conductive portion 301 and the second conductive portion 302 use different arc-shaped tube walls in the circumferential direction of the same tubular structure as the first conductive portion 301 and the second conductive portion 302, respectively, and the first conductive portion 301 and the second conductive portion. The tube wall structure between 302 is an insulating area, thereby electrically isolating the first conductive portion 301 and the second conductive portion 302 .

It should also be noted that, in some other embodiments, the first conductive portion 301 and the second conductive portion 302 may also adopt a split structure, as described in detail below.

Referring to FIGS. 23 and 24 , in this embodiment, a part of the skeleton structure of the sealing portion 11 is used as the first ablation member 21 , and the first ablation member 21 conducts electricity through the skeleton structure in the sealing portion 11 and is then electrically connected to the first conductive portion 301 . The ablation electrode disposed on the support frame 10 serves as the second ablation member 22 , and the second ablation member 22 is electrically connected to the second conductive portion 302 through the second wire 202 .

It can be understood that, the first ablation member 21 may also use an ablation electrode, and the ablation electrode and the first conductive portion 301 are connected through a first wire. Alternatively, the second ablation member 22 may also adopt a partial skeleton structure of the anchoring portion 12 and be connected and electrically connected to the second conductive portion 302 .

It should be noted that the first wire is used to connect between the ablation electrode and the first conductive part 301, or the second wire 202 is used to connect between the ablation electrode and the second conductive part 302. After the delivery device 200 is released, the first The guide wire and the second guide wire 202 will not be exposed from the proximal end of the sealing portion 11 , so the possibility of the occurrence of thrombosis of the device can be effectively reduced.

Referring to FIG. 23 , in this embodiment, the first conductive portion 301 and the second conductive portion 302 are both disposed on the proximal side of the support frame 10 , and the first ablation member 21 and the second ablation member 22 are both close to the support frame 10 . Near-end settings. Further, the first conductive portion 301 is disposed on the proximal end surface of the supporting frame 10 and extends proximally from the proximal end surface of the self-supporting frame 10, that is, protrudes outward from the proximal end surface of the self-supporting frame 10, and the second conductive portion 302 is connected to the proximal end surface of the self-supporting frame 10. The insulating section 303 is disposed on the distal side of the proximal end face of the support frame 10 and is received in the lumen formed by the support frame 10 . In some embodiments, the first conductive portion 301 , the second conductive portion 302 and the insulating section 303 may all be disposed on the proximal side of the proximal end surface of the support frame 10 , or may all be disposed on the distal side of the proximal end surface.

In some other embodiments, the first conductive part 301 and the second conductive part 302 may also be disposed at the distal end of the support skeleton 10 , correspondingly, at least one of the first ablation member 21 and the second ablation member 22 is close to the support frame The remote setting of 10 will not be repeated here.

Please refer to FIG. 23 to FIG. 24 , the insulating section 303 between the first conductive portion 301 and the second conductive portion 302 is a protruding annular insulating structure, and the protruding annular insulating structure is disposed near the sealing portion 11 . The distal side of the end surface is disposed between the sealing portion 11 and the second conductive portion 302 , so as to avoid electrical connection between the sealing portion 11 and the second conductive portion 302 .

It should be noted that, the insulating section 303 may also be provided without protruding. Specifically, the outer peripheral wall surface of the insulating section 303 may be flush with the outer peripheral wall surfaces of the first conductive portion 301 and the second conductive portion 302 .

Referring to FIG. 24 , in this embodiment, the first conducting portion 211 and the second conducting portion 212 in the conveying device 200 are tubular structures that are insulated from each other and integrally formed. The first conducting portion 211 and the second conducting portion 212 are both disposed at the distal end of the delivery device 200 , and the first conducting portion 211 is located on the proximal side of the second conducting portion 212 .

It can be understood that, in some other embodiments, the first conducting portion 211 and the second conducting portion 212 may also adopt a split structure.

For the ninth embodiment, refer to the structures shown in FIGS. 25 and 26 .

FIG. 25 is a schematic structural diagram of a left atrial appendage occlusion and ablation system provided by the ninth embodiment of the present invention. FIG. 26 is a schematic structural diagram of the conveying device 200 in FIG. 25 .

Referring to FIGS. 25 to 26 , in the left atrial appendage occlusion and ablation system provided in this embodiment, the occlusion and ablation device 100 is a single-disc structure. The occlusion and ablation device 100 includes a support frame 10 , a conductive connection member, a first ablation member 21 and a second ablation member 22 . The conductive connector includes a first conductive portion 301 and a second conductive portion 302 . The conducting member of the conveying device 200 includes a first conducting portion 211 and a second conducting portion 212 which are insulated from each other.

Referring to FIG. 25 , in this embodiment, the support frame 10 adopts a grid-like frame structure which is integrally cut. The difference from the support frame 10 in the eighth embodiment is that the distal end of the support frame 10 is a closed structure. Meanwhile, the first conductive portion 301 and the second conductive portion 302 are mutually independent structures, that is, the first conductive portion 301 and the second conductive portion 302 are provided separately. The first conductive portion 301 is disposed at the proximal end of the support frame 10 , and the second conductive portion 302 is disposed at the distal end of the support frame 10 .

In some other embodiments, the support frame 10 may also adopt a mesh-like frame structure formed by weaving.

Referring to FIG. 25 , in the support frame 10 , the proximal end portion of the support frame 10 is the sealing portion 11 , and the proximal end of the sealing portion 11 is bundled and connected to the first conductive portion 301 . The distal end portion of the support frame 10 is the anchoring portion 12 , and the distal end of the anchoring portion 12 is bundled and connected to the second conductive portion 302 . The distal end of the sealing portion 11 is connected to the proximal end of the anchoring portion 12 .

In some embodiments, an insulating connector is provided between the second conductive part 302 and the support frame 10 to connect the second conductive part 302 and the support frame 10 in an insulating manner. At this time, the support frame 10 can conduct electricity as a whole while maintaining the connection with the support frame 10 . The second conductive portion 302 is electrically isolated.

It can be understood that an insulating connector may also be provided between the first conductive portion 301 and the support frame 10, so that the first conductive portion 301 is connected to the support frame 10 in an insulating manner. At this time, the support frame 10 can conduct electricity as a whole while maintaining It is electrically isolated from the first conductive portion 301 .

Referring to FIG. 25 , in this embodiment, the first ablation member 21 is a partial skeleton structure supporting the proximal end of the frame 10 , that is, at least part of the proximal end side of the sealing portion 11 serves as the first ablation member 21 . The second ablation member 22 is a partial skeleton structure supporting the distal end of the skeleton 10 , that is, at least a part of the distal side of the anchoring portion 12 serves as the second ablation member 22 . The support frame 10 is provided with an insulating segment 23a between the first ablation member 21 and the second ablation member 22, that is, the frame in the connection area between the sealing portion 11 and the anchoring portion 12 is used as the insulating segment 23a, as shown in FIG. 25 . The skeleton structure in 23a is insulated, so as to electrically isolate the first ablation member 21 from the second ablation member 22 .

In some embodiments, the skeleton structure in the insulating segment 23a may be made of insulating polymer materials, such as metal conductive material as the first ablation member 21 and second ablation member 22, and the insulating polymer material as the middle In the insulating section 23a, the metal conductive material and the insulating polymer material are connected by a melting process.

Referring to FIG. 26 , in this embodiment, the first conducting portion 211 and the second conducting portion 212 are of the aforementioned split structure. Specifically, the first conducting portion 211 and the second conducting portion 212 are nested inside and outside. The first conducting portion 211 is a tubular structure, the second conducting portion 212 is movably penetrated in the first conducting portion 211 , and the second conducting portion 212 and the first conducting portion 211 are electrically isolated from each other. Preferably, the first conducting part 211 and the second conducting part 212 are arranged coaxially. The proximal ends of the second conduction part 212 and the first conduction part 211 can be connected to the same external ablation energy source or to different external ablation energy sources, so that the first conduction part 211 and the second conduction part 212 can transmit the same or different ablation energy .

Referring to FIGS. 25 and 26 , the distal end of the first conducting portion 211 is threadedly and electrically connected to the first conducting portion 301 , and further provides ablation energy to the first ablation element 21 through the first conducting portion 31 . The distal end of the second conducting portion 212 passes through the center of the first conducting portion 301 and protrudes into the support frame 10, and the distal end of the second conducting portion 212 is screwed and electrically connected to the second conducting portion 302, and further The second ablation member 22 is provided with ablation energy through the second conductive portion 302 .

The distal ends of the first conducting portion 211 and the second conducting portion 212 are connected to the first conducting portion 301 or the second conducting portion 302 by means of threads, so as to facilitate the connection between the first conducting portion 211 and the first conducting portion 211 after the tissue ablation is completed. The conducting portion 301 is rotated and disengaged, and the second conducting portion 212 and the second conducting portion 302 are rotated and disengaged.

FIG. 27 is another structural schematic diagram of the second conductive portion 302 and the conveying device 200 in FIG. 25 .

Please refer to FIG. 27 , in conjunction with FIGS. 25 and 26 , the conveying device 200 of this embodiment is similar in structure to the conveying device 200 in FIG. 26 , and the conveying device 200 includes a first conducting portion 211 and a second conducting portion 212 . The first conducting portion 211 and the second conducting portion 212 are nested inside and outside, preferably, the first conducting portion 211 and the second conducting portion 212 are coaxially arranged. The second conducting portion 212 is movably penetrated in the first conducting portion 211 .

The first conductive portion 301 is disposed at the proximal end of the support frame 10 , and the second conductive portion 302 is disposed at the distal end of the support frame 10 . The first conducting portion 211 is electrically and rotatably connected to the first conducting portion 301 , and the second conducting portion 212 is electrically and rotatably connected to the second conducting portion 302 . The main difference between this embodiment and the conveying device 200 in FIG. 26 is that the connection structure of the second conducting portion 212 and the second conducting member 302 is different.

Specifically, referring to FIG. 27 , in this embodiment, the structure of the second conductive portion 302 is the same as that of the conductive connecting member 30 shown in FIGS. 3 to 5 , and the structure of the second conductive portion 212 is the same as that shown in FIG. 3 . The conductive member 210 is the same, and the second conductive portion 302 and the second conductive portion 212 are electrically connected through a claw-type connection. For the specific structures and connection relationships of the second conductive portion 302 and the second conductive portion 212 , reference may be made to the related descriptions in FIGS. 3 to 5 , which will not be repeated here.

For the tenth embodiment, please refer to the structure of FIG. 28 .

Please refer to FIG. 28 , and in conjunction with FIG. 21 , the left atrial appendage occlusion and ablation system provided in this embodiment is similar in structure to the left atrial appendage occlusion and ablation system of the embodiment of FIG. 21 . The shape and structure of the support frame of the 21 embodiment are the same. The difference between the occlusion and ablation device of this embodiment and the occlusion and ablation device of FIG. 21 is that the ablation assembly includes a first ablation member 21 and a second ablation member 22 , and correspondingly, the conductive connection member includes a first conductive portion 301 and a second ablation member guide portion 302 . In addition, the delivery device of this embodiment also includes a first conducting portion 211 and a second conducting portion 212 .

In this embodiment, the first ablation member 21 is provided on the sealing portion 11 , and the second ablation member 22 is provided on the anchor portion 12 . The first ablation member 21 may adopt at least a partial skeleton structure of the sealing portion 11 , or may adopt an ablation electrode disposed on the sealing portion 11 . Similarly, the second ablation member 22 may adopt at least part of the skeleton structure of the anchoring portion 12 , and may also adopt an ablation electrode disposed on the anchoring portion 12 .

The first conductive portion 301 is arranged on the sealing portion 11, and the second conductive portion 302 is arranged on the anchoring portion 12. The sealing portion 11 and the anchoring portion 12 are connected by a skeleton connecting piece 130, and the skeleton connecting piece 130 is an insulating material. , thereby insulating and isolating the sealing portion 11 from the anchoring portion 12 . At the same time, the skeleton connecting member 130 can also be used for insulating connection between the first conductive part 301 and the second conductive part 302 , and for insulating the first ablation part 21 and the second ablation part 22 .

In this embodiment, the first conductive portion 301 is disposed at the proximal end of the sealing portion 11 , and the distal end of the first conductive portion 211 is electrically and rotatably connected to the first conductive portion 301 .

The second conductive portion 302 may be disposed at the proximal end of the anchor portion 12 , or the second conductive portion 302 may be disposed at the distal end of the anchor portion 12 , or the second conductive portion 302 may be disposed at the proximal end and the distal end of the anchor portion 12 In the meantime, without limitation, in this embodiment, the second conductive portion 302 is provided at the distal end of the anchor portion 12 . The second conductive portion 212 penetrates through the first conductive portion 211 , passes through the frame connecting member 130 , and extends into the support frame 10 to be electrically connected to and rotatably connected to the second conductive portion 302 .

The first conductive portion 301 is electrically connected to the first ablation member 21 , and the first conductive portion 211 can transmit ablation energy to the first ablation member 21 through the first conductive portion 301 . The second conductive portion 302 is electrically connected to the second ablation member 22 , such as through a second wire, and the second conductive portion 212 can transmit ablation energy to the second ablation member 22 through the second conductive portion 302 . The first ablation element 21 and the second ablation element 22 are used to transmit electrical ablation energy with different parameters.

It should be noted that, in some other embodiments, the first ablation member 21 and the second ablation member 22 may both be disposed on the anchor portion 12, and in this case, the first conductive portion 301 and the second conductive portion 302 are respectively disposed on The proximal end and the distal end of the anchoring portion 12, and the first conductive portion 301 and the second conductive portion 302 are insulated from each other. The connecting piece is realized, or a skeleton made of insulating material is arranged on the sealing part 11 or the anchoring part 12 . In some embodiments, the first conductive portion 301 and the second conductive portion 302 are provided at the same end of the anchor portion 12, or both are provided integrally.

It can be understood that, in some other embodiments, the first ablation member 21 and the second ablation member 22 may also be both disposed on the sealing portion 11 , and in this case, the first conductive portion 301 and the second conductive portion 302 are respectively provided on the sealing portion 11 . The proximal and distal ends of the portion 11 . In addition, the first conductive portion 301 and the second conductive portion 302 are insulated from each other, and the implementation of the insulation can refer to the foregoing solution. In some embodiments, the first conductive portion 301 and the second conductive portion 302 are provided at the same end of the sealing portion 11 , or both are provided integrally.

Referring to FIG. 28 , in this embodiment, the first conducting portion 211 and the second conducting portion 212 are nested inside and outside. The first conducting portion 211 is tubular, the second conducting portion 212 is movably penetrated in the first conducting portion 211 , and the second conducting portion 212 and the first conducting portion 211 are electrically isolated from each other.

The conveying apparatus of this embodiment may adopt the structure of the conveying apparatus 200 shown in FIG. 26 . That is, the first conductive portion 211 is screwed and electrically connected to the first conductive portion 301 , and the second conductive portion 212 is screwed and electrically connected to the second conductive portion 302 . After the tissue ablation is completed, the first conducting portion 211 and the first conducting portion 301 are circumferentially separated from each other, and the second conducting portion 212 and the second conducting portion 302 are circumferentially separated from each other.

As an alternative, the conveying device of this embodiment can also adopt the structure of the conveying device shown in FIG. 27 , and correspondingly, the second conductive portion of this embodiment is configured in the shape of the second conductive portion shown in FIG. 27 . That is, the first conductive portion 211 is screwed and electrically connected to the first conductive portion 301. After the first conductive portion 211 is combined with the first conductive portion 301, the inner cavity of the first conductive portion 301 still retains the second conductive portion 212. Passing through the channel, the second conducting portion 212 passes through the channel formed inside the first conducting portion 301 , is threadedly connected with the clamping sleeve 31 of the second conducting portion 302 , and abuts against the clamping jaw 32 of the second conducting portion 302 and is connected with it. Make electrical connections. After the tissue ablation is completed, the second conducting portion 212 and the clamping sleeve 31 of the second conducting portion 302 are rotated and disengaged relative to the circumferential direction, and the first conducting portion 211 and the first conducting portion 301 are rotated and disengaged relative to the circumferential direction.

In some embodiments, the first conductive portion 301 may also adopt the claw-type structure shown in FIG. 27 , and the claw-type first conductive portion 301 retains a channel through which the second conductive portion 212 can pass.

It should be noted that, in some other embodiments, the first conducting portion 211 and the second conducting portion 212 may also adopt a structure that is insulated from each other and integrally formed. In this case, the first conducting portion 211 is located at the proximal end of the second conducting portion 212 side. For details, reference may be made to the structure of the conveying device 200 in the embodiment of FIG. 24 , which will not be repeated here.

For the eleventh embodiment, please refer to the structure of FIG. 29 .

FIG. 29 is a schematic structural diagram of an occlusion and ablation device 100 according to an eleventh embodiment of the present invention.

Please refer to FIG. 29 , in conjunction with FIG. 28 , the occlusion and ablation device 100 provided in this embodiment is similar in structure to the occlusion and ablation device 100 of the embodiment of FIG. 28 , and the support frame 10 is a double-disc structure. The main difference between the occlusion and ablation device of this embodiment and the embodiment of FIG. 28 is that in the support frame 10 of this embodiment, the structure of the sealing part 11 , the structure of the anchoring part 12 , and the gap between the sealing part 11 and the anchoring part 12 connection structure is different. In addition, the positions of the first conductive portion 301 and the second conductive portion 302 are also different from those in FIG. 28 .

Referring to FIG. 29 , in this embodiment, the sealing portion 11 adopts a grid-like skeleton structure formed by weaving, and the cross-section of the sealing portion 11 is formed in a trapezoidal structure. The size of the seal portion 11 in the present embodiment in the axial direction is larger than that of the seal portion 11 in FIG. 28 . Specifically, the sealing portion 11 is further provided with an intermediate portion between the proximal disk surface and the distal disk surface. The disk surface on the proximal side and the disk surface on the far side are roughly flat, and the radial dimension of the disk surface on the distal side is smaller than that on the disk surface on the proximal side. It is attached to the tissue at the opening of the left atrial appendage to improve the adherence performance of the sealing portion 11 .

The sealing part 11 is provided with a first ablation member 21 . The sealing part 11 may be a part of the skeleton structure conductive or the whole skeleton as the first ablation member 21 . The conductive skeleton in the sealing portion 11 is in direct contact with the first conductive member 301 to conduct electricity. In a preferred embodiment, the first conductive member 301 is also used to condense the proximal end of the skeleton structure in the proximal disk surface of the sealing portion 11 . In a variant embodiment, an ablation electrode may also be provided on the sealing portion 11 and electrically connected to the first conducting portion 211 through a first wire fitting.

The anchoring portion 12 adopts a skeleton structure formed by integral cutting. The anchor portion 12 is provided with a second ablation member 22 . The anchor 12 may be part of the skeleton or the entire skeleton as the second ablation member 22 . Alternatively, an ablation electrode may be provided on the anchoring portion 12 and electrically connected to the second conducting portion 212 through a second wire fitting.

In this embodiment, the anchoring portion 12 includes a plurality of main rods 121 and a plurality of anchor rods 122 , and the plurality of anchor rods 122 are arranged around the outer circumference of the plurality of main rods 121 . The plurality of main rods 121 are arranged at intervals in the circumferential direction, and gradually spread from the proximal end to the distal end, forming a shape similar to a horn, and an opening toward the distal end is formed between the plurality of main rods 121 . The distal end of the anchor rod 122 is connected to the distal end of the main rod 121 , and the anchor rod 122 extends from the distal end of the main rod 121 to the proximal direction.

In this embodiment, the end of the anchor rod 122 away from the main rod 121 is bent and extended toward the center side and toward the distal end to form a return hook structure. And the end of any anchoring rod 122 away from the main rod 121 is connected with the corresponding end of an adjacent anchoring rod 122 , thereby maintaining the distance between the adjacent anchoring rods 122 and improving the anchoring portion 12 overall structural strength.

As shown in FIG. 29 , in this embodiment, a strut 123 is formed between the distal end of the main rod 121 and the anchor rod 122 . The distal end of the main rod 121 is connected with at least two struts 123, the two struts 123 extend in different directions, and are respectively connected with different anchor rods 122, thereby forming a plurality of main rods 121 and a plurality of anchor rods 122 Circumferentially connected skeleton structure.

In this embodiment, a frame connecting member 130 is provided between the sealing portion 11 and the anchoring portion 12 , and at least part of the frame connecting member 130 is made of insulating material, so as to insulate the sealing portion 11 and the anchoring portion 12 . connect.

In some embodiments, the first conductive member 301 is disposed at the proximal end of the sealing part 11 , and the first conductive part 301 is used for electrical connection with the first conductive part 211 , and at the same time, the space between the ablation device 100 and the delivery device 200 is occluded. mechanical connection. The proximal end of the braided wire of the sealing portion 11 is bundled and connected to the first conductive portion 301 . The distal end of the braided wire of the sealing portion 11 is bundled and connected to a distal connecting piece 111 . The distal connecting member 111 is connected to the proximal end of the skeleton connecting member 130, for example, by means of screw connection, or adhesion, snap connection, snap connection, interference fit and the like. Specifically, the distal connector 111 can be a double-layer steel sleeve, and the distal end of the frame in the sealing portion 11 can be contained in the gap between the double-layer steel sleeves. In some embodiments, the double-layer steel sleeve and the frame are connected Additional need for welding to fix. In some embodiments, the distal end of the skeleton of the sealing portion 11 is fixed to the distal connecting member 111 by welding, bonding, snap-fitting or the like.

Please refer to FIG. 29 , one end of the anchoring portion 12 is bundled and connected to the second conductive portion 302 , and the second conductive portion 302 is connected to the distal end of the skeleton connecting member 130 , and the two can be screwed or bonded or clamped therebetween. , snap connection, interference fit, etc. Therefore, insulation connection between the distal connector 111 and the conductive connector 30 can be performed through the skeleton connector 130 .

It should be noted that, the first conductive portion 301 , the distal end connector 111 and the skeleton connector 130 are all tubular structures, and the inner channel can allow the second conductive portion 212 to pass through, so that the second conductive portion 212 can pass through the first conductive portion 212 . After a conductive portion 301 , the distal connecting piece 111 and the skeleton connecting piece 130 , are electrically connected to the second conducting portion 302 and connected rotatably.

It can be understood that, the distal connecting piece 111 at the distal end of the sealing portion 11 may be made of conductive material, or may be made of insulating material.

Referring to FIG. 29 , in some embodiments, the skeleton connecting member 130 may include a plurality of connecting members connected in sequence in the axial direction, the proximal ends of the plurality of connecting members are connected with the sealing portion 11 , and the plurality of connecting members The distal end is connected to the second conductive part 302 . And among the plurality of connectors of the skeleton connector 130, at least one connector is made of insulating material.

Please refer to FIG. 29 , and in conjunction with FIG. 26 , the occlusion and ablation device 100 of this embodiment can be matched with the delivery device 200 of the embodiment of FIG. 26 to realize electrical connection and rotational connection between the occlusion and ablation device 100 and the delivery device 200 . At this time, the first conductive portion 211 is screwed and electrically connected to the first conductive portion 301 , and the second conductive portion 212 is screwed to and electrically connected to the second conductive portion 302 . After the tissue ablation is completed, the first conducting portion 211 and the first conducting portion 301 are rotated and separated in the circumferential direction, and the second conducting portion 212 and the second conducting portion 302 are circumferentially separated from each other, thereby realizing the occlusion and ablation device 100 and the delivery device 200. electrical connection between and turn the connection.

Please refer to FIG. 29 , and in conjunction with FIG. 27 , the occlusion and ablation device 100 of this embodiment can be matched with the first conduction part 211 and the second conduction part 212 of the embodiment of FIG. 27 to realize the occlusion and ablation device 100 and the delivery device 200 between electrical and rotational connections. At this time, the first conductive portion 211 is screwed and electrically connected to the first conductive portion 301 , the second conductive portion 212 is screwed to the clamping sleeve 31 of the second conductive portion 302 , and is connected to the clamping jaw 32 of the second conductive portion 302 . electrical connection. After the tissue ablation is completed, the first conducting portion 211 and the first conducting portion 301 are rotated and disengaged in the circumferential direction, and the second conducting portion 212 and the clamping sleeve 31 of the second conducting portion 302 are rotated and disengaged in the circumferential direction, thereby realizing the closure and ablation device 100 . The electrical connection and the rotational connection between the delivery device 200.

It should be noted that the occlusion and ablation device 100 in this embodiment can also be matched with the delivery device 200 in the embodiment of FIG. 24 to realize electrical connection and rotational connection between the occlusion and ablation device 100 and the delivery device 200 . If not contradictory, the occlusion and ablation device 100 of this embodiment can be matched with the delivery device 200 provided by various embodiments of the present application.

It can be understood that, in the alternative embodiment of FIGS. 28 and 29 , only one set of ablation components may be provided, and one conductive connector may be provided accordingly, for example, the conductive connector is the second conductive connector in FIG. 28 or FIG. 29 . Section 302. In this case, the delivery device 200 includes an inner tube 220 and an outer tube 230 arranged coaxially inside and outside. The outer tube 230 is configured as a non-conductive structure for connection with the proximal connector. The inner tube 220 is configured as a conductive structure, and the inner tube 220 is used as a conductive member 210 for electrically connecting with the conductive connecting member. Specifically, the claw-type structure in the embodiment of FIG. 3 may be adopted between the inner tube 220 of the conveying device 200 and the conductive connecting member. The ablation component is electrically connected to the conductive connector through a wire. Alternatively, the delivery device may also adopt the structure in the embodiment of FIG. 2 or FIG. 22 to achieve electrical connection and circumferential rotational connection between the occlusion and ablation device 100 and the delivery device 200 .

In some embodiments, only one set of ablation components is provided, and one conductive connector is correspondingly provided, for example, the conductive connector is the first conductive portion 301 in FIG. 28 or FIG. 29 . In this case, the delivery device 200 includes a conductive member 210 as shown in FIG. 2 for electrical connection with the conductive connection member.

In the twelfth embodiment, refer to the structure shown in FIG. 30 .

FIG. 30 is a schematic structural diagram of the occlusion and ablation device 100 provided by the twelfth embodiment 5 of the present invention.

Please refer to FIG. 30 , in conjunction with FIG. 29 , the occlusion and ablation device 100 provided in this embodiment is similar in structure to the occlusion and ablation device 100 of the embodiment of FIG. 29 . The main difference of this embodiment lies in the structure of the second ablation member 22 and the connection structure between the sealing part 11 and the anchoring part 12 .

Referring to FIG. 30 , in this embodiment, the second ablation member 22 is an ablation electrode disposed on the anchor portion 12 . Part of the skeleton or the entire skeleton of the sealing portion 11 is used as the first ablation member 21 .

The ablation electrode is bent and extended along the circumferential direction of the anchor portion 12 to form an annular band-shaped ablation electrode. Specifically, the second ablation member 22 may adopt a substantially zigzag structure or a wavy structure formed by bending a conductive wire, and is fixed and surrounds the anchoring portion 12 by welding, bonding, suturing, other fixing members participating in the fixing, etc. Circumferential arrangement.

It should be noted that, in other embodiments, the second ablation member 22 may be implemented in the form of a point electrode, a ring electrode, a rod electrode, a catheter provided with electrodes, and the like. The first ablation member 21 may also use an ablation electrode disposed on the sealing portion 11 .

Referring to FIG. 30 , in this embodiment, a frame connecting member 130 is provided between the sealing portion 11 and the anchoring portion 12 . The frame connecting member 130 includes a first connecting member 131 , a second connecting member 132 and a third connecting member 133 which are connected in sequence along the axial direction.

The first connecting member 131 is disposed at the distal end of the sealing portion 11 . The braided wire at the distal end of the sealing portion 11 is bundled and connected to the first connector 131 .

In this embodiment, the first conductive portion 301 is provided at the proximal end of the sealing portion 11 , and the proximal end of the braided wire of the sealing portion 11 is bundled and connected to the first conductive portion 301 . The distal end of the sealing portion 11 is provided with a distal connector 111. The distal connector 111 and the first connector 131 can adopt the structure of inner and outer steel sleeves as described above. The distal connector 111 is located on the inner side, and the first connector 131 is located on the outside, and further sandwiches and bundles the distal end of the braided wire of the sealing portion 11 between the distal connecting piece 111 and the first connecting piece 131 . The first conductive portion 210 of the delivery device 200 can be directly electrically connected to the first conductive portion 301 and screwed.

It can be understood that, in some other embodiments, the first conductive portion 301 may also be provided at the distal end of the sealing portion 11 , and the first conductive portion 301 and the first connecting member 131 adopt the structure of inner and outer connection, and the first conductive portion 301 is located on the inner side, and the first connecting member 131 is located on the outer side, so that the distal end of the braided wire of the sealing portion 11 is sandwiched and bundled between the first conductive portion 301 and the first connecting member 131 . The first conductive portion 210 of the delivery device 200 can extend into the sealing portion 11 , and is electrically and threadedly connected to the first conductive portion 301 at the distal end of the sealing portion 11 .

It should be noted that, the first connecting member 131 may be made of insulating material or conductive material, which is not limited herein.

Referring to FIG. 30 , the proximal end of the second connecting member 132 is connected to the first connecting member 131 , for example, through screw connection, or adhesion, snap connection, snap connection, interference fit and the like. The proximal end of the third connecting member 133 is connected to the distal end of the second connecting member 132 , for example, through screw connection, or adhesion, snap connection, snap connection, interference fit and the like. One end of the anchoring portion 12 is constricted and connected to the third connecting piece 133 .

In some embodiments, the third connecting member 133 may adopt a double-layer sleeve structure, so as to bundle the end of the anchoring portion 12 and sandwich it between the double-layer sleeves.

In some embodiments, both the second connecting member 132 and the third connecting member 133 are made of insulating material, or one of the second connecting member 132 and the third connecting member 133 is made of insulating material, so that the sealing portion 11 can be An insulating connection is formed with the anchor portion 12 .

In some embodiments, the second connecting member 132 and the third connecting member 133 may adopt a one-piece tubular structure and be made of insulating material. The end of the anchoring portion 12 is bundled and fixed on the outer peripheral wall of the one-piece tubular structure, and is connected by structures such as interference fit connection, hook, etc., or by bonding or melting.

Please refer to FIG. 30 , the second conductive portion 302 is disposed at the distal end of the third connecting member 133 , specifically, is disposed on the inner side of the third connecting member 133 , and the second conductive portion 302 is electrically connected to the second ablation member 22 through a second wire . Preferably, the third connecting member 133 is made of insulating material, so as to ensure that the second conductive portion 302 and the third connecting member 133 and the skeleton in the anchoring portion 12 are insulated from each other, avoiding the second ablation member 22 and the anchoring portion 12 . The skeletons in the conductors conduct electricity to each other.

The second conducting part 212 of the conveying device 200 can pass through the channels formed in the first connecting part 131 , the second connecting part 132 and the third connecting part 133 , protrude into the third connecting part 133 , and connect with the second conducting part 302 . Electrically connected and screwed. Furthermore, after the tissue ablation is completed, the second conducting portion 212 and the second conducting portion 302 are rotated and disengaged in the circumferential direction, and the first conducting portion 211 and the first conducting portion 301 are rotated and disengaged in the circumferential direction.

Please refer to FIG. 30 , and in conjunction with FIGS. 24 , 26 and 27 , the occlusion and ablation device 100 of this embodiment can use the first conduction part 211 and the second conduction part 212 of the embodiment in FIG. 24 to cooperate to achieve occlusion and ablation For the electrical connection and rotational connection between the device 100 and the delivery device 200 , the delivery device 200 in the embodiment shown in FIG. 26 or FIG. 27 can also be used to cooperate to realize the electrical connection and rotational connection between the occlusion and ablation device 100 and the delivery device 200 . .

The thirteenth embodiment, refer to the structure shown in FIG. 31 .

FIG. 31 is a schematic structural diagram of the occlusion and ablation device 100 provided by the thirteenth embodiment of the present invention.

Please refer to FIG. 31 and in conjunction with FIG. 30 , the occlusion and ablation device 100 provided in this embodiment is similar in structure to the occlusion and ablation device 100 in the embodiment of FIG. 30 . A first connecting piece 131 , a second connecting piece 132 and a third connecting piece 133 are arranged between the sealing portion 11 and the anchoring portion 12 in sequence along the axial direction. The main difference of this embodiment is that the end of the anchoring portion 12 and the sealing portion 11 are connected differently.

Referring to FIG. 31 , in this embodiment, the end of the anchoring portion 12 is sandwiched between the second connecting member 132 and the third connecting member 133 . Both the second connector 132 and the third connector 133 are insulating connectors. Preferably, the end of the anchoring portion 12 is bundled and sleeved on the outer circumference of the second connecting member 132 .

Please refer to FIG. 31 , in conjunction with FIGS. 24 , 26 and 27 , the occlusion and ablation device 100 of this embodiment can also use the first conducting portion 211 and the second conducting portion 212 of the embodiment in FIG. 24 to cooperate to achieve occlusion Electrical and rotational connections between ablation device 100 and delivery device 200 . Or use the delivery device 200 of the embodiment in FIG. 26 or FIG. 27 to cooperate to realize the electrical connection and rotational connection between the occlusion and ablation device 100 and the delivery device 200 .

For the fourteenth embodiment, refer to the structure shown in FIG. 32 .

FIG. 32 is a schematic structural diagram of the occlusion and ablation device 100 provided by the fourteenth embodiment of the present invention.

Please refer to FIG. 32 , in conjunction with FIG. 29 , the occlusion and ablation device 100 provided in this embodiment is similar in structure to the occlusion and ablation device 100 of the embodiment of FIG. 29 . Compared with the occlusion and ablation device 100 in the embodiment of FIG. 29 , the main difference of this embodiment is that the sealing part 11 and the anchoring part 12 of the occlusion and ablation device 100 are provided with first connecting members which are sequentially connected in the axial direction. 131 , the second connecting piece 132 and the third connecting piece 133 ; in addition, in this embodiment, the anchoring portion 12 uses an ablation electrode additionally disposed on the skeleton structure as the second ablation piece 22 , and the second ablation piece 22 is connected to the anchor The skeleton structures of the parts 12 are insulated from each other.

Referring to FIG. 32 , in the present embodiment, a fourth connecting member 134 is disposed between the third connecting member 133 and the second conductive portion 302 , and the fourth connecting member 134 is made of insulating material for connecting the third connecting member 133 to the second conductive portion 302 . An insulating connection is formed between the second conductive parts 302 .

Referring to FIG. 32 , in this embodiment, the third connecting member 133 is made of conductive material, and is used for constricting the end of the anchoring portion 12 . The second connecting member 132 is made of insulating material, and is used to form an insulating connection between the sealing portion 11 and the anchoring portion 12 . The first connecting piece 131 is used to condense the distal end of the sealing portion 11 . The first connecting member 131 may be made of insulating material or conductive material, which is not limited herein. The fourth connecting member 134 is made of insulating material, and is used to form an insulating connection between the third connecting member 133 and the second conductive portion 302 .

Referring to FIG. 32 , in this embodiment, the first conductive portion 301 is disposed at the proximal end of the sealing portion 11 , that is, the proximal end of the sealing portion 11 is bundled and connected to the first conductive portion 301 . The distal end of the sealing portion 11 is connected between a distal connecting piece 111 and the first connecting piece 131 . It can be understood that, in other embodiments, the first conductive portion 301 is provided at the distal end of the sealing portion 11 , and the proximal end of the sealing portion 11 is bundled and connected to a proximal connecting member 112 .

Further, the fourth connecting member 134 is disposed on the inner side of the third connecting member 133 . The second conductive portion 302 is disposed on the inner side of the fourth connecting member 134, and the connection between the two can be screwed, or bonded, snap-fit, snap-fit, or interference fit. The second conducting portion 212 of the delivery device 200 can pass through the axially extending channel formed by the first connecting piece 131 , the second connecting piece 132 , the third connecting piece 133 and the fourth connecting piece 134 , and extend into the fourth connecting piece 134 . inside, and is electrically connected and screwed to the second conductive portion 302 . Furthermore, after the tissue ablation is completed, the second conducting portion 212 and the clamping sleeve 31 of the second conducting portion 302 are rotated and separated from each other in the circumferential direction.

Please refer to FIG. 32 , and in conjunction with FIGS. 24 , 26 and 27 , the occlusion and ablation device 100 of this embodiment can also use the first conducting portion 211 and the second conducting portion 212 of the embodiment in FIG. 24 to cooperate to achieve occlusion Electrical and rotational connections between ablation device 100 and delivery device 200 . Alternatively, the delivery device 200 of the embodiment shown in FIG. 26 or FIG. 27 can be used to cooperate to realize the electrical connection and rotational connection between the occlusion and ablation device 100 and the delivery device 200 .

In the fifteenth embodiment, refer to the structures shown in FIGS. 33 and 34 .

FIG. 33 is a schematic structural diagram of the occlusion and ablation device 100 provided by the fifteenth embodiment of the present invention.

Please refer to FIG. 33 , in conjunction with FIG. 29 , the occlusion and ablation device 100 provided in this embodiment is similar in structure to the occlusion and ablation device 100 of the embodiment of FIG. 29 . The main difference is that the structure between the sealing part 11 and the first conductive part 301 is different.

Referring to FIG. 33 , in this embodiment, the first conductive portion 301 is disposed at the distal end of the sealing portion 11 . The distal end of the sealing part 11 is connected to the first conductive part 301 in a converging manner. At the same time, the proximal end of the sealing portion 11 is constricted and connected to a proximal connecting piece 112 , and the proximal connecting piece 112 may be made of a conductive material or an insulating material, which is used to connect with the delivery device 200 . Remove the connection. In addition, one end of the anchoring portion 12 is bundled and connected to the second conductive portion 302, and the second conductive portion 302 is connected to the distal end of the skeleton connecting member 130, for example, by screw connection, or bonding, snap connection, and snap connection. , interference fit, etc. The first conductive portion 301 is connected to the proximal end of the skeleton connecting member 130 , for example, through screw connection, or adhesion, snap connection, snap connection, interference fit, and the like. Therefore, the first conductive portion 301 and the second conductive portion 302 are insulated and connected through the skeleton connecting member 130 . FIG. 34 is a schematic structural diagram of the delivery device 200 matched with the occlusion and ablation device 100 in FIG. 33 .

Please refer to FIG. 34 and in conjunction with FIG. 33 , the delivery device 200 provided in this embodiment is compatible with the occlusion and ablation device 100 of the embodiment of FIG. 33 . In this embodiment, the delivery device 200 includes an inner tube 220 and an outer tube 230 that are coaxially arranged inside and outside. The first conducting portion 211 and the second conducting portion 212 are integrally formed at the distal end of the inner tube 220, and the first conducting portion 211 is located at the distal end of the inner tube 220. On the proximal side of the second conducting portion 212 , the first conducting portion 211 and the second conducting portion 212 are arranged at intervals, and the first conducting portion 211 and the second conducting portion 212 are insulated from each other.

In some embodiments, the first conducting portion 211 and the second conducting portion 212 are two mutually insulated threaded segments disposed at the distal end of the inner tube 220 , and the first conducting portion 211 and the second conducting portion 212 can be used for transmission Two different ablation energies.

Referring to FIGS. 33 and 34 , when the delivery device 200 of this embodiment is connected to the occlusion and ablation device 100 of the embodiment of FIG. 33 , the distal end of the outer tube 230 is connected to the proximal connector 112 at the proximal end of the sealing portion 11 . Circumferential rotation is connected. The first conductive portion 211 on the inner tube 220 is circumferentially rotated and electrically connected to the first conductive portion 301 at the distal end of the sealing portion 11 . The second conductive portion 212 on the inner tube 220 and the second conductive portion 302 on the anchor portion 12 are circumferentially rotationally connected and electrically connected.

After the tissue ablation is completed, the outer tube 230 can be circumferentially disengaged from the proximal connector 112 , the first conductive portion 211 on the inner tube 220 can be circumferentially separated from the first conductive portion 301 , and the second conductive portion 220 The conductive portion 212 may be rotationally disengaged from the second conductive portion 302 in the circumferential direction.

It should be noted that, in some embodiments, the inner tube 220 may also adopt a split structure, such as the structure of the first conducting portion 211 and the second conducting portion 212 in FIGS. 26 and 27 . That is, the above-mentioned manner of circumferential rotation connection may be a threaded connection manner, a clamping claw manner, or other circumferential rotation connection manners commonly used in the art.

Sixteenth embodiment, refer to the structure shown in FIG. 35 .

FIG. 35 is a schematic structural diagram of the occlusion and ablation device 100 provided by the sixteenth embodiment of the present invention.

Please refer to FIG. 35 , in conjunction with FIG. 33 , the occlusion and ablation device 100 provided in this embodiment is similar in structure to the occlusion and ablation device 100 of the embodiment of FIG. 33 , the main difference is that the first ablation member 21 and the second ablation member 22 are both provided on the anchor portion 12 .

Referring to FIG. 35 , in this embodiment, the first ablation member 21 and the second ablation member 22 are both fixed on the peripheral wall of the anchoring portion 12 in the form of ablation electrodes. In addition, the first ablation member 21 and the second ablation member 22 are insulated and spaced apart from each other.

It should be noted that, in some other embodiments, the first ablation member 21 and the second ablation member 22 may also be formed by conductive parts of the skeleton structure of the anchoring portion 12 . Or one of them is conductively formed by part of the skeleton structure of the anchoring part 12 , and the other is formed by using an ablation electrode disposed on the outer peripheral wall of the anchoring part 12 .

Referring to FIG. 35 , the first conductive portion 301 is disposed at the distal end of the sealing portion 11 , and the distal end of the sealing portion 11 is constricted and connected to the first conductive portion 301 . Meanwhile, the sealing portion 11 may be made of insulating material. The proximal end of the sealing portion 11 is constricted and connected to a proximal end connecting piece 112, and the proximal end connecting piece 112 is a tubular structure with a channel formed therein. The end of the anchoring portion 12 is connected to the second conductive portion 302 in a bundle. A frame connecting member 130 is disposed between the first conducting portion 301 and the second conducting portion 302 .

The first conductive part 301 can be electrically connected to the first ablation part 21 through a first wire, the second conductive part 302 can be electrically connected to the second ablation part 22 through a second wire, and the first ablation part 21 and the skeleton of the anchoring part 12 The structures can be insulated from each other, the second ablation member 22 and the skeleton structure of the anchoring part 12 can be insulated from each other, and the anchoring part 12 can be made of insulating material. In some embodiments, the inner part of the second conductive part 302 is electrically conductive, so as to be electrically connected between the second wire and the second conductive part; the outer part of the second conductive part 302 is insulated to ensure the second wire and the anchoring part 12 skeleton insulation.

Please refer to FIG. 35 , and in conjunction with FIG. 34 , the occlusion and ablation device 100 of this embodiment can also be matched with the delivery device 200 of the embodiment in FIG. Electrical and rotational connections between delivery devices 200 .

In some embodiments, an ablation element may also be provided on the sealing portion 11 , which may be at least part of the skeleton structure in the sealing portion 11 for transmitting ablation power to the tissue, or an ablation electrode may be provided on the peripheral wall of the sealing portion 11 . At this time, the proximal connecting piece 112 at the proximal end of the sealing portion 11 is also made of conductive material, so that the distal end of the outer tube can be connected and electrically connected with the proximal connecting piece 112 in the circumferential direction so as to pass through the proximal connecting piece 112 delivers ablation energy to the conductive portion or ablation electrode on the sealing portion 11 .

In some embodiments, the sealing portion 11 may be made of insulating material, and a skeleton connecting member 130 is further provided between the distal end of the sealing portion 11 and the first conductive portion 301 . The skeleton connector 130 is made of insulating material and is arranged on the outer side of the distal end of the sealing part 11 , the first conductive part 301 is arranged on the inner side of the distal end of the sealing part 11 , and the first conductive part 301 and the skeleton connector 130 form an inner and outer casing In the structure, the first conductive portion 301 is located on the inner side, the skeleton connecting member 130 is located on the outer side, and the distal end of the sealing portion 11 is bundled and connected to the outer periphery of the skeleton connecting member 130 .

In some embodiments, the sealing portion 11 is made of a conductive material, and a conductive connecting member is used to constrict the distal end of the sealing portion 11 . In this case, an insulating member with an insulating material needs to be arranged between the conductive connecting member and the first conductive portion 301 . The performance backbone connector 130 is electrically isolated.

For the seventeenth embodiment, refer to the structure shown in FIG. 36 .

FIG. 36 is a schematic structural diagram of the occlusion and ablation device 100 provided by the seventeenth embodiment of the present invention.

Please refer to FIG. 36 and in conjunction with FIG. 33 , the occlusion and ablation device 100 provided in this embodiment is similar in structure to the occlusion and ablation device 100 of the embodiment of FIG. 33 . The main difference is that the first ablation member 21 and the second ablation member 22 are both disposed on the sealing portion 11 .

Referring to FIG. 36 , in this embodiment, the first ablation member 21 and the second ablation member 22 are both fixed on the outer peripheral wall of the sealing portion 11 in the form of ablation electrodes. In addition, the first ablation member 21 and the second ablation member 22 are insulated and spaced apart from each other. Specifically, the first ablation member 21 and the second ablation member 22 are electrode rings arranged at a distance from each other.

It should be noted that, in other embodiments, the first ablation member 21 and the second ablation member 22 may also be formed by conductive parts of the skeleton structure of the sealing portion 11 . Or one of them is conductively formed by part of the skeleton structure of the sealing part 11 , and the other is formed by an ablation electrode disposed on the outer peripheral wall of the sealing part 11 .

Referring to FIG. 36 , in this embodiment, the proximal end of the sealing portion 11 is bundled and connected to the proximal connecting member 112 . The distal end of the sealing part 11 is connected to the first conductive part 301 in a converging manner. The first ablation member 21 is electrically connected to the first conductive portion 301 .

A frame connecting member 130 is provided between the sealing portion 11 and the anchoring portion 12 . The end of the anchoring portion 12 is constricted and connected to the outer periphery of the frame connecting member 130 . The frame connecting member 130 includes a plurality of connecting members which are axially connected in sequence. It can be understood that, the frame connecting member 130 can also adopt an integrally formed tubular structure.

The second conductive portion 302 is disposed at the distal end of the skeleton connecting member 130 and is insulated from the first conductive portion 301 . The second ablation member 22 is electrically connected to the second conductive portion 302 .

Please refer to FIG. 36 , and in conjunction with FIG. 34 , the occlusion and ablation device 100 of this embodiment can also be matched with the delivery device 200 of the embodiment in FIG. Electrical and rotational connections between delivery devices 200 .

In other embodiments, the first conductive portion 301 may also be provided at the proximal end of the sealing portion 11 . Specifically, the proximal end of the sealing portion 11 is bundled and connected to the first conductive portion 301 . The second conductive portion 302 may be provided at the distal end of the sealing portion 11 , and specifically, the distal end of the sealing portion 11 is connected to the second conductive portion 302 in a bundle. The surface of the sealing portion 11 is insulated or made of insulating material, so that the first conductive portion 301 and the second conductive portion 302 are insulated from each other, and the first ablation member 21 and the second ablation member 22 on the sealing portion 11 are insulated from each other. Meanwhile, the first ablation member 21 is electrically connected to the first conductive portion 301 , and the second ablation member 22 is electrically connected to the second conductive portion 302 , thereby providing ablation energy for the first ablation member 21 and the second ablation member 22 respectively.

The frame connecting member 130 includes a first connecting member 131 , a second connecting member 132 and a third connecting member 133 which are connected in sequence along the axial direction. The first connecting member 131 is used to bind the distal end of the skeleton structure in the sealing portion 11 together with the first conductive portion 301 , the third connecting member 133 is used to fixedly connect with one end of the anchoring portion 12 , and the second conductive portion 302 is disposed on the The distal ends of the three connectors 133 . The second connecting piece 132 is connected between the first connecting piece 131 and the third connecting piece 133 .

The insulation between the first conductive part 301 and the second conductive part 302 is achieved by the skeleton connecting member 130, for example, at least one of the first connecting member 131, the second connecting member 132 and the third connecting member 133 is insulated. The two connecting pieces 132 are at least surface insulated, or are made of insulating materials. Under the condition that at least the surface of the third connecting member 133 is insulated, the anchoring portion 12 can be insulated from the first conductive portion 301 and the second conductive portion 302 from each other. In this embodiment, the sealing portion 11 may be made of insulating material, or the surface of the skeleton structure thereof may be treated with insulating treatment.

For the eighteenth embodiment, refer to the structure shown in FIG. 37 .

FIG. 37 is a schematic structural diagram of an occlusion and ablation device 100 according to an eighteenth embodiment of the present invention.

Please refer to FIG. 2627 , in conjunction with FIGS. 22 and 33 , the occlusion and ablation device 100 provided in this embodiment is similar in structure to the occlusion and ablation device 100 in the embodiments of FIGS. 22 and 33 . The sealing portion 11 is a skeleton structure formed by weaving. The anchoring portion 12 adopts a skeleton structure formed by integral cutting. The first ablation member 21 is provided on the sealing portion 11 , and the second ablation member 22 is provided on the anchor portion 12 . Compared with the occlusion and ablation device 100 in the embodiments of FIGS. 22 and 33 , the main difference between the occlusion and ablation device 100 in this embodiment is that the skeleton structures of the sealing portion 11 and the anchoring portion 12 are different.

Referring to FIG. 37 , in some embodiments, the sealing portion 11 uses part or all of the skeleton to conduct electricity to form the first ablation member 21 . The anchoring portion 12 uses part or all of the skeleton to conduct electricity to form the second ablation member 22 . It can be understood that the first ablation member 21 may include an ablation electrode disposed on the sealing portion 11 , and the second ablation member 22 may include an ablation electrode disposed on the anchor portion 12 .

In the occlusion and ablation device 100 of the embodiments shown in FIGS. 22 and 33 , the entire longitudinal section of the sealing portion 11 is in a trapezoidal structure. The distal and proximal disk surfaces of the sealing portion 11 are approximately planar. In this embodiment, the entire longitudinal section of the sealing portion 11 is in a tapered structure, the distal surface of the sealing portion 11 is a tapered surface, and the proximal surface of the proximal surface of the sealing portion 11 is a flat surface. It can be understood that, in some other embodiments, the proximal face disk of the sealing portion 11 may also be an arc-shaped surface or a conical surface.

In this embodiment, the anchoring portion 12 includes a plurality of main rods 121 , a plurality of anchor rods 122 , and a plurality of struts 123 connected between the main rods 121 and the anchor rods 122 . The distal end of each main rod 121 is connected to at least two supporting rods 123, the two supporting rods 123 extend in different directions, and are respectively connected to an anchor rod 122, so that a plurality of main rods 121 and a plurality of anchor rods 122 A skeletal structure is formed that is connected circumferentially around. The struts 123 can be used to improve the radial support force of the anchoring portion 12 while ensuring that the adjacent anchoring rods 122 maintain a preset distance. The support frame 10 is not easily entangled with each other during loading and releasing of the support frame 10 .

In the occlusion and ablation device 100 in the embodiments of FIGS. 22 and 33 , the end of the anchor rod 122 away from the main rod 121 is connected to the end of an adjacent anchor rod 122 away from the main rod 121 . In this embodiment, the end of the anchor rod 122 away from the main rod 121 is a free end, and the free end of the anchor rod 122 is bent toward the center side from the end of the anchor rod 122 away from the support rod 123 and toward the distal end Bend extension.

In this embodiment, the strut 123 is located at the most distal end of the anchoring portion 12 . When the outer periphery of the anchoring portion 12 is wound with the ablation electrode, it is beneficial to keep the adjacent anchoring rods 122 at a preset distance.

In some embodiments, the sealing part 11 and the anchoring part 12 are provided with a skeleton connector 130, which can be any of the skeleton connectors 130 in the occlusion and ablation device 100 shown in FIGS. 18 to 25 and 36 . structure, which will not be repeated here.

In some embodiments, the sealing portion 11 is provided with a first conductive portion 301, and the anchor portion 12 is provided with a second conductive portion 302, wherein the structures of the first conductive portion 301 and the second conductive portion 302 can be any of the foregoing The structures of the first conductive portion 301 and the second conductive portion 302 of the embodiment will not be repeated here. The skeleton connector 130 may be disposed between the first conductive portion 301 and the second conductive portion 302 .

It can be understood that, the specific technical solutions provided by the above embodiments can be mutually applicable in the case where there is no mutual exclusion, and the occlusion and ablation device and the delivery device provided by each embodiment can be used in any combination in the case that they are not mutually exclusive. For example, the threaded connection between any conductive connecting piece and the conducting piece can be replaced by the snap connection provided by the above embodiments, and the threaded connection between any conductive part and the corresponding conductive part can be replaced by the snap connection provided by the above embodiments The support frame in the occlusion and ablation device can also be replaced by the support frame of different shapes or structures in the above-mentioned other embodiments, which will not be repeated here. The conductors shown in FIGS. 7-15 only show the portion of the conductor for interconnecting with the conductive connection, ie only the distal end of the conductor is shown, and the proximal portion of the conductor is not shown.

While the present invention has been described with reference to a number of exemplary embodiments, it is to be understood that the terminology used is of description and illustration, and not of limitation. Since the invention can be embodied in many forms without departing from the spirit or spirit of the invention, it is to be understood that the above-described embodiments are not limited to any of the foregoing details, but are to be construed broadly within the spirit and scope defined by the appended claims Therefore, all changes and modifications that come within the scope of the claims or their equivalents should be covered by the appended claims.

Claims

A left atrial appendage occlusion and ablation system, characterized in that it comprises a occlusion and ablation device and a delivery device, the occlusion and ablation device is implanted and occluded at the opening of the left atrial appendage, and the delivery device is used to seal the sealing and ablation device. The occlusion ablation device is delivered to the opening of the left atrial appendage;

The occlusion and ablation device includes:

The support body can radially expand and contract, and is used to block the opening of the left atrial appendage;

an ablation component, arranged on the support body, and used for transmitting ablation electrical energy to the left atrial appendage tissue and/or collecting electrophysiological signals of the left atrial appendage tissue;

A conductive connector is used for electrical connection between the delivery device and the ablation component; the conductive connector and the delivery device are connected or disconnected from each other through relative rotation.
The left atrial appendage occlusion and ablation system according to claim 1, wherein the delivery device comprises a conductive member, the conductive member is used for electrical connection with the conductive connection member, and is connected to or disconnected from each other through rotational connection .
The left atrial appendage occlusion and ablation system according to claim 2, wherein the distal end of the conducting member is threadedly connected to the conducting connecting member.
The left atrial appendage occlusion and ablation system according to claim 2, wherein the conductive connecting member comprises a clamping claw and a clamping sleeve; the clamping sleeve is provided on the support body, and the clamping claw is movable is arranged in the clamping sleeve; the conducting member is threadedly connected to the clamping sleeve, and the distal end of the conducting member extends into the clamping sleeve to abut against the clamping claw and is conductively connected, and the conducting member The abutment of the piece against the jaws can make the jaws close to each other to clamp the wire, and the ends of the wire away from the jaws are used to electrically connect the ablation assembly.
The left atrial appendage occlusion and ablation system according to claim 4, wherein a receiving cavity is formed in the clamping sleeve through the proximal end and the distal end thereof, and the cavity diameter of the distal end of the receiving cavity is from the proximal end to the distal end. The distal end gradually becomes smaller;

The clamping claw is movably arranged in the receiving cavity, the clamping claw comprises a base and a plurality of claw arms movably arranged at the distal end of the base, and the plurality of claw arms are arranged at intervals along the circumferential direction and are adjacent to each other. A gap is formed between the claw arms; the claw arms are used to abut against the inner wall of the distal end of the clamping sleeve;

The abutting of the conducting member to the clamping jaws can make the plurality of jaw arms close to each other to clamp the wire.
The left atrial appendage occlusion and ablation system according to claim 4 or 5, wherein the clamping sleeve is made of insulating material; the conducting member comprises a main body part and a resisting part protruding from the distal end of the main body part ;

The outer wall of the distal end of the main body portion is in threaded connection with the clamping sleeve, and the abutting portion extends into the receiving cavity and abuts against the clamping claw.
The left atrial appendage occlusion and ablation system according to any one of claims 4-6, wherein a limiting portion is protruded on the inner wall of the clamping sleeve, and the limiting portion is located at the proximal end of the inner wall of the receiving cavity , a hole is formed in the center of the limiting portion;

The distal end of the conducting member can extend into the receiving cavity through the through hole and abut against the clamping claw, so as to push the clamping claw to move to the distal side in the receiving cavity.
The left atrial appendage occlusion and ablation system according to claim 2, wherein the conductive connecting member and the conductive member are connected through a snap hole and an elastic sheet to cooperate with each other, and the conductive member and the conductive connecting member are connected to each other. The relative rotation between the two can make the elastic piece snap into the snap hole or disengage from the snap hole.
The left atrial appendage occlusion and ablation system according to claim 8, wherein the surface of at least one circumferential side of the elastic piece is arc-shaped.
The left atrial appendage occlusion and ablation system according to any one of claims 8 or 9, wherein the elastic sheet is disposed on the main body portion of the conductive connecting member or the conducting member, and both ends of the elastic sheet in the circumferential direction Both are connected to the main body, and the part between the two ends in the circumferential direction of the elastic sheet protrudes in a direction away from or close to the axis of the main body along the radial direction of the main body.
The left atrial appendage occlusion and ablation system according to any one of claims 8 to 10, wherein the elastic piece comprises two convex parts and a concave part connected between the two convex parts, and the two convex parts are spaced apart in the circumferential direction It is provided that the convex portion and the concave portion protrude in opposite directions along the radial direction of the main body portion.
The left atrial appendage occlusion and ablation system according to claim 12, wherein one of the two convex portions comprises an outer arm portion connected to the main body portion, and the outer arm portion moves away from the main body portion The direction of the axis is convex.
The left atrial appendage occlusion and ablation system according to claim 11 or 12, wherein one of the two convex portions comprises an outer arm portion connected to the main body portion, and the outer arm portion is flat.
The left atrial appendage occlusion and ablation system according to claim 2, wherein the conductive connecting member and the conducting member are connected through a snap hole and a pawl, wherein the pawl is an elastic component, and the Rotation of the conducting member relative to the conductive connecting member in a first direction can enable the pawl to be engaged in or disengaged from the locking hole.
The left atrial appendage occlusion and ablation system according to claim 14, wherein the conducting member further comprises a main body portion, the pawl is protrudingly disposed on the circumferential surface of the main body portion, and the pawl is a wedge-shaped block The radial surface of the pawl is tangent to the surface of the body portion.
The left atrial appendage occlusion and ablation system according to claim 2, wherein the conductive connecting member and the conductive member are connected to each other through a snap groove and a protrusion, and the conductive member and the conductive connecting member are connected to each other. The relative rotation and relative movement of the protrusions can make the protrusions snap into the snap grooves or disengage from the snap grooves.
The left atrial appendage occlusion and ablation system according to claim 18, wherein the snap groove is disposed on the conductive connecting member or the conductive member, and the snap groove comprises an entrance section, a limit section and a connection A connecting section between the inlet section and the limiting section, the inlet section passing through the axial end face of the conductive connecting piece or the conducting piece and extending toward the other end in the axial direction, the limiting section at the conductive connecting piece The connecting section extends between the axial ends of the conductive piece or the conducting piece, the connecting section is disposed away from the axial end face of the conductive connecting piece or the conducting piece, the connecting section extends in the circumferential direction, and the connecting section One end of the inlet section is connected to one end of the inlet section away from the end face of the conductive connecting piece or the conducting piece, and the other end of the connecting section is connected to one end of the limiting section.
The left atrial appendage occlusion and ablation system according to any one of claims 2 to 17, wherein the support body comprises a proximal connector, and the conductive connector is located on the distal side of the proximal connector, The delivery device includes an inner tube and an outer tube, the inner tube movably passes through the outer tube, the distal end of the inner tube is set as the conducting member, and the distal end of the inner tube is connected to the conductive connecting member Connection or disconnection is achieved by relative rotation.
The left atrial appendage occlusion and ablation system according to claim 2, wherein,

The conductive connector includes a first conductive portion and the second conductive portion that are insulated from each other;

The ablation assembly includes a first ablation member and a second ablation member which are insulated from each other and provided on the support body;

the first conductive portion and the second conductive portion are respectively electrically connected to the first ablation member and the second ablation member;

Both the first conductive portion and the second conductive portion are connected to or disconnected from the conveying device through relative rotation.
The left atrial appendage occlusion and ablation system according to claim 19, wherein the first conductive part and the second conductive part are an integral structure insulated from each other.
The left atrial appendage occlusion and ablation system according to claim 19, wherein the first conductive portion and the second conductive portion are integrally disposed with an insulating connection portion therebetween, so that the first conductive portion is connected to the The second conductive parts are connected to each other in insulation.
The left atrial appendage occlusion and ablation system according to any one of claims 19 to 21, wherein the conducting member comprises a first conducting portion and a second conducting portion that are insulated from each other, and the first conducting portion is used for connecting with The first conductive parts are electrically connected, and are connected or disconnected from each other through rotational connection; the second conductive parts are used for electrical connection with the second conductive parts, and are connected or disconnected from each other by rotational connection.
The left atrial appendage occlusion and ablation system according to claim 22, wherein the first conduction part and the second conduction part are an integral structure insulated from each other.
The left atrial appendage occlusion and ablation system according to claim 22, wherein the first conductive portion is disposed on the proximal side of the second conductive portion, the first conductive portion is an outer tube, and the second conductive portion is an outer tube. The second conducting portion is an inner tube, and the second conducting portion is movably penetrated in the first conducting portion.
The left atrial appendage occlusion and ablation system according to claim 23 or 24, wherein the first conducting portion is connected with the first conducting portion by screwing or snapping, and the second conducting portion is connected with the first conducting portion. The two conductive parts are screwed or snap-connected.
The left atrial appendage ablation system according to claim 25, wherein the snap connection is realized by one of the following methods:

a) A snap hole and an elastic piece that cooperate with each other are provided between the conducting member and the conductive connecting piece. When the conducting piece and the conducting connecting piece rotate relative to each other, the elastic piece can be snapped into the snapping piece hole or disengage from the snap hole;

b) A snap hole and a ratchet pawl are arranged between the conducting member and the conducting connecting member. When the conducting member and the conducting connecting member rotate relative to each other, the ratcheting claw can be snapped into the snap holes or disengagement from said snap holes; and

c) A snap groove and a protrusion that cooperate with each other are provided between the conductive member and the conductive connector, and the protrusion can slide along the snap groove, and the conductive member and the conductive connector are in contact with each other. The relative rotation and relative movement can make the protrusion snap into the snap groove or disengage from the snap groove.
The left atrial appendage occlusion and ablation system according to claim 24, wherein the second conductive part comprises a clamping claw and a clamping sleeve; the clamping sleeve is arranged on the support body, and the clamping claw is movable The second conducting part is threadedly connected to the clamping sleeve, and the distal end of the second conducting part extends into the clamping sleeve to abut against the clamping claw and conduct electricity connection, the second conducting portion against the clamping jaws can make the clamping jaws close to each other to clamp the wire, and the ends of the wire away from the clamping jaws are used to electrically connect the second ablation components.
The left atrial appendage occlusion and ablation system according to claim 27, wherein a receiving cavity is formed in the clamping sleeve through a proximal end and a distal end thereof, and the diameter of the distal end of the receiving cavity is from the proximal end to the distal end. The distal end gradually becomes smaller;

The clamping claw is movably arranged in the receiving cavity, the clamping claw comprises a base and a plurality of claw arms movably arranged at the distal end of the base, and the plurality of claw arms are arranged at intervals along the circumferential direction and are adjacent to each other. A gap is formed between the claw arms; the claw arms are used to abut against the inner wall of the distal end of the clamping sleeve;

The abutting of the second conducting portion to the clamping jaws can make the plurality of jaw arms close to each other to clamp the wire.
The left atrial appendage occlusion and ablation system according to claim 27 or 28, wherein the clamping sleeve is made of an insulating material; the second conducting part comprises a main body part and a bearing protruding from the distal end of the main body part holding department;

The outer wall of the distal end of the main body portion is in threaded connection with the clamping sleeve, and the abutting portion extends into the receiving cavity and abuts against the clamping claw.
The left atrial appendage occlusion and ablation system according to any one of claims 27-29, wherein a limiting portion is protruded on the inner wall of the clamping sleeve, and the limiting portion is located at the proximal end of the inner wall of the receiving cavity , a hole is formed in the center of the limiting portion;

The distal end of the second conducting portion can extend into the receiving cavity through the through hole and abut with the clamping claw, so as to push the clamping claw to move to the distal end side in the receiving cavity.
The left atrial appendage occlusion and ablation system according to any one of claims 1 to 30, wherein the ablation assembly comprises at least part of the support body, or comprises an ablation electrode disposed on the support body.
The left atrial appendage occlusion and ablation system according to any one of claims 1 to 31, wherein the support body comprises a sealing part at the proximal end for closing the opening of the left atrial appendage and a sealing part at the distal end for sealing the opening of the left atrial appendage. An anchoring part for anchoring the inner wall of the left atrial appendage;

The ablation assembly is provided on the sealing portion and/or the anchoring portion.
The left atrial appendage occlusion and ablation system according to any one of claims 19 to 31, wherein the support body comprises a sealing part at the proximal end for closing the opening of the left atrial appendage and an anchor at the distal end for anchoring The anchoring part of the inner wall of the left atrial appendage;

The first ablation piece and the first conductive portion are arranged on the sealing portion, and the second ablation piece is arranged on the anchor portion.
The left atrial appendage occlusion and ablation system according to claim 32 or 33, wherein the sealing part or the end of the anchoring part is bundled and connected to the conductive connector.
The left atrial appendage occlusion and ablation system according to any one of claims 32 to 34, wherein the sealing portion and the anchoring portion are both disc-shaped structures, and the sealing portion and the anchoring portion are both disc-shaped structures. The parts are connected by at least one insulating connecting piece.
The left atrial appendage occlusion and ablation system according to claim 35, wherein the at least one insulating connecting piece comprises two insulating connecting pieces, and one end of the anchoring portion is sandwiched between the two insulating connecting pieces between.
The left atrial appendage occlusion and ablation system according to claim 36, wherein the end of the anchoring portion is fixed by a metal piece, and the metal piece is sandwiched between the two insulating connecting pieces.