CN116392561B - Traditional Chinese medicine composition for treating cough caused by damp-heat invading lung and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating cough caused by damp-heat invading lung and preparation method thereof Download PDFInfo
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- CN116392561B CN116392561B CN202310617287.1A CN202310617287A CN116392561B CN 116392561 B CN116392561 B CN 116392561B CN 202310617287 A CN202310617287 A CN 202310617287A CN 116392561 B CN116392561 B CN 116392561B
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Abstract
The invention discloses a traditional Chinese medicine composition for treating cough caused by damp-heat invading lung, which is prepared from the following raw materials in parts by weight: 5-25 parts of wine baical skullcap root, 5-25 parts of cardamom, 2-18 parts of honeysuckle, 5-25 parts of weeping forsythia, 5-25 parts of wrinkled gianthyssop herb, 2-18 parts of peppermint, 5-25 parts of heartleaf houttuynia herb, 2-18 parts of thunberg fritillary bulb, 2-18 parts of platycodon root, 5-25 parts of officinal magnolia bark, 2-18 parts of blackberry lily, 5-25 parts of radix isatidis, 5-25 parts of virgate wormwood herb, 5-25 parts of talcum, 5-25 parts of common monkshood mother root, 5-25 parts of grassleaf sweetflag rhizome, 5-25 parts of stir-fried hyacinth bean and 1-9 parts of liquorice. The composition is used for treating cough caused by damp-heat invading lung, and is accompanied with symptoms such as pharyngeal discomfort, chest distress, epigastric fullness, aversion to cold, heaviness of head and body, hypodynamia and the like, and has obvious clinical curative effect.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating cough caused by damp-heat invading lung.
Background
With warming climate, change of eating habit and change of season climate, cough caused by damp-heat invading lung is more and more increased, and the cough has the susceptibility and the lesion tendency to cause other diseases. Cough due to damp-heat (i.e. cough caused by damp-heat invading lung) is caused by damp-heat evil blocking lung qi and damp-heat viscosity affecting the dispersing and descending of lung. Cough of damp-heat type is evident in the evening or night, and aggravates cough due to temperature changes or tiredness. Cough of damp-heat type can occur all the year round, and generally has good prognosis, and if the cough is not treated in time or is not treated by mistake, the cough is difficult to heal for a long time or is easy to cause other symptoms. In traditional Chinese medicine, the ' damp-heat syndrome ' is recorded in ' damp-heat disease, cough is not safe at all, and even asthma cannot sleep. Therefore, the pathogenesis of the damp-heat type cough is related to the cough caused by damp-heat accumulation caused by damp-heat invasion of the lung or lung lesions caused by damp-heat due to the exogenous damp-heat and spleen and stomach dysfunction.
The research history of traditional Chinese medicine for treating cough, especially cough caused by damp-heat invading lung is long, for example, clinical research of cough damp-heat stagnation lung syndrome after infection by Fufei Hua Shi Zhi Tang (Ding Zhaohui) published in 2015 in the 7 th volume 33 of J.traditional Chinese medicine clinical research, a traditional Chinese medicine prescription for treating cough caused by damp-heat stagnation lung type is disclosed, the curative effect is superior to that of traditional Chinese medicine conventional treatment, but adverse reactions such as stomach discomfort, dizziness and the like still exist, the curative effect is still required to be further improved, and a better curative effect and safer traditional Chinese medicine preparation for treating cough caused by damp-heat invading lung is required to be clinically urgently provided, and the life quality of patients is improved.
Disclosure of Invention
In order to solve the problems, the invention provides a traditional Chinese medicine composition for treating cough caused by damp-heat invading lung, which is prepared from the following raw materials in parts by weight:
5-25 parts of wine baical skullcap root, 5-25 parts of cardamom, 2-18 parts of honeysuckle, 5-25 parts of weeping forsythia, 5-25 parts of wrinkled gianthyssop herb, 2-18 parts of peppermint, 5-25 parts of heartleaf houttuynia herb, 2-18 parts of thunberg fritillary bulb, 2-18 parts of platycodon root, 5-25 parts of officinal magnolia bark, 2-18 parts of blackberry lily, 5-25 parts of radix isatidis, 5-25 parts of virgate wormwood herb, 5-25 parts of talcum, 5-25 parts of common monkshood mother root, 5-25 parts of grassleaf sweetflag rhizome, 5-25 parts of stir-fried hyacinth bean and 1-9 parts of liquorice.
Further, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight:
10-20 parts of wine baical skullcap root, 10-20 parts of cardamon, 5-15 parts of honeysuckle, 10-20 parts of weeping forsythia, 10-20 parts of wrinkled gianthyssop herb, 5-15 parts of peppermint, 10-20 parts of heartleaf houttuynia herb, 5-15 parts of thunberg fritillary bulb, 5-15 parts of platycodon root, 10-20 parts of officinal magnolia bark, 5-15 parts of blackberry lily, 10-20 parts of indigowoad root, 10-20 parts of virgate wormwood herb, 10-20 parts of talcum, 10-20 parts of common monkshood mother root, 10-20 parts of grassleaf sweetflag rhizome, 10-20 parts of stir-fried hyacinth bean and 1-6 parts of liquorice.
Further, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight:
15 parts of wine baical skullcap root, 15 parts of cardamom, 10 parts of honeysuckle, 15 parts of weeping forsythia, 15 parts of wrinkled gianthyssop herb, 10 parts of peppermint, 15 parts of heartleaf houttuynia herb, 10 parts of thunberg fritillary bulb, 10 parts of platycodon root, 15 parts of officinal magnolia bark, 10 parts of blackberry lily, 15 parts of Indigowoad root, 15 parts of virgate wormwood herb, 15 parts of talcum, 15 parts of common clematis stem, 15 parts of grassleaf sweelflag rhizome, 15 parts of stir-fried hyacinth bean and 3 parts of liquorice.
Furthermore, the preparation is prepared by taking medicinal powder of the raw material medicine or water or organic solvent extract of the raw material medicine as an active ingredient and adding pharmaceutically acceptable auxiliary materials.
Further, the formulation is an oral formulation; the oral preparation is mixture, granule, capsule, tablet, oral liquid or syrup.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:
(1) Weighing the raw materials according to the proportion;
(2) Extracting the raw materials with water, filtering the extractive solution, concentrating, standing, packaging, and sterilizing.
Further, the times of extraction in the step (2) are 2 times, the extraction time is 33 minutes each time, and the water adding multiple is 7.8 times; the concentration is to be carried out until the relative density at 70 ℃ is not lower than 1.06; the standing is refrigeration standing.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating cough caused by damp-heat invading the lung.
Further, the medicine is a medicine for treating cough caused by damp-heat invading the lung.
The traditional Chinese medicine composition consists of eighteen medicines of wine baical skullcap root, round cardamon seed, honeysuckle, weeping forsythiae capsule, wrinkled gianthyssop herb, peppermint, heartleaf houttuynia herb, thunberg fritillary bulb, platycodon root, officinal magnolia bark, blackberry lily, indigowoad root, virgate wormwood herb, talcum, common akebia stem, grassleaf sweelflag rhizome, stir-fried hyacinth bean and liquoric root. It is indicated for damp-warm disease, epidemic disease, pathogenic qi stagnation and damp-heat affecting lung. When the damp-heat is exchanged and steamed, the head and the body are heavy and the body are weak; chest oppression and epigastric fullness can occur due to obstruction of the middle-jiao of dampness; the heat toxin is accumulated upwards, so thirst, sore throat and cough; when damp-heat is downward flowing, urine is scanty and reddish, or diarrhea and stranguria; white or thick greasy or dry yellow coating is the sign of retention of qi in the interior due to damp-heat. For relieving exterior syndrome, resolving dampness, clearing heat and relieving cough. In the recipe, baical skullcap root, cardamon, talcum and capillary artemisia are used, wherein Baical skullcap root has the effects of clearing heat and drying dampness, clearing fire and detoxicating, cardamon has the effects of promoting qi circulation and removing dampness, talcum has the effects of promoting diuresis and clearing summer-heat, capillary artemisia has the effects of clearing damp-heat and relieving jaundice, and four medicines are combined and the pathogenesis of damp-heat is combined together, so that the Baical skullcap root is taken as a monarch drug. The damp-heat is retained and is easy to block the qi movement, so grassleaved sweetflag rhizome, wrinkled giant hyssop, officinal magnolia bark and stir-fried hyacinth bean are used as ministerial drugs for promoting qi circulation, eliminating dampness, strengthening spleen and regulating middle warmer, and promoting qi circulation; akebia stem, caulis Akebiae has the effects of clearing heat, promoting diuresis and treating stranguria, and guiding damp-heat from urination to benefit the effects of clearing heat and promoting diuresis. Because of the upward attack of heat toxin and the swelling and sore throat, fructus forsythiae, blackberry lily, fritillaria, peppermint, honeysuckle, radix isatidis, houttuynia cordata and platycodon grandiflorum are added, and the effects of clearing heat and detoxicating, relieving cough and relieving sore throat are combined. The medicines are combined together to play the roles of relieving exterior syndrome, resolving dampness, clearing heat and relieving cough. Can be used for treating symptoms caused by damp-heat invading lung such as pharyngeal discomfort, cough, chest distress, gastric fullness, aversion to cold, heaviness of head and body, debilitation, etc., with remarkable clinical curative effect.
It should be apparent that, in light of the foregoing, various modifications, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.
The above-described aspects of the present invention will be described in further detail below with reference to specific embodiments in the form of examples. It should not be understood that the scope of the above subject matter of the present invention is limited to the following examples only. All techniques implemented based on the above description of the invention are within the scope of the invention.
Detailed Description
EXAMPLE 1 preparation of the composition of the invention
The formula comprises the following components: 15 parts of wine baical skullcap root, 15 parts of cardamom, 10 parts of honeysuckle, 15 parts of weeping forsythia, 15 parts of wrinkled gianthyssop herb, 10 parts of peppermint, 15 parts of heartleaf houttuynia herb, 10 parts of thunberg fritillary bulb, 10 parts of platycodon root, 15 parts of officinal magnolia bark, 10 parts of blackberry lily, 15 parts of Indigowoad root, 15 parts of virgate wormwood herb, 15 parts of talcum, 15 parts of common clematis stem, 15 parts of grassleaf sweelflag rhizome, 15 parts of stir-fried hyacinth bean and 3 parts of liquorice.
The preparation method comprises the following steps: weighing the raw materials according to the proportion, adding 7.8 times of water, decocting and extracting for 2 times, each time for 33min, filtering, concentrating the filtrate until the relative density is not lower than 1.06 (70 ℃), refrigerating and standing for 24-72 h, pouring and sterilizing to obtain the solution.
EXAMPLE 2 preparation of the medicament of the invention
The formula comprises the following components: 10 parts of wine radix scutellariae, 10 parts of cardamon, 5 parts of honeysuckle, 10 parts of weeping forsythia, 10 parts of wrinkled gianthyssop herb, 5 parts of peppermint, 10 parts of heartleaf houttuynia herb, 5 parts of thunberg fritillary bulb, 5 parts of platycodon root, 10 parts of officinal magnolia bark, 5 parts of blackberry lily, 10 parts of radix isatidis, 10 parts of virgate wormwood herb, 10 parts of talcum, 10 parts of common clematis stem, 10 parts of grassleaf sweelflag rhizome, 10 parts of stir-fried hyacinth bean and 1 part of liquorice
The preparation method comprises the following steps: weighing the raw materials according to the proportion, adding 7.8 times of water, decocting and extracting for 2 times, each time for 33min, filtering, concentrating the filtrate until the relative density is not lower than 1.06 (70 ℃), refrigerating and standing for 24-72 h, pouring and sterilizing to obtain the solution.
EXAMPLE 3 preparation of the medicament of the invention
The formula comprises the following components: 20 parts of wine baical skullcap root, 20 parts of cardamon, 15 parts of honeysuckle, 20 parts of weeping forsythia, 20 parts of wrinkled gianthyssop herb, 15 parts of peppermint, 20 parts of heartleaf houttuynia herb, 15 parts of thunberg fritillary bulb, 15 parts of platycodon root, 20 parts of officinal magnolia bark, 15 parts of blackberry lily, 20 parts of indigowoad root, 20 parts of virgate wormwood herb, 20 parts of talcum, 20 parts of common clematis stem, 20 parts of grassleaf sweelflag rhizome, 20 parts of stir-fried hyacinth bean and 6 parts of liquorice
The preparation method comprises the following steps: weighing the raw materials according to the proportion, adding 7.8 times of water, decocting and extracting for 2 times, each time for 33min, filtering, concentrating the filtrate until the relative density is not lower than 1.06 (70 ℃), refrigerating and standing for 24-72 h, pouring and sterilizing to obtain the solution.
EXAMPLE 4 preparation of the medicament of the invention
The formula comprises the following components: 5 parts of wine baical skullcap root, 5 parts of cardamon, 2 parts of honeysuckle, 5 parts of weeping forsythia, 5 parts of wrinkled gianthyssop herb, 2 parts of peppermint, 5 parts of heartleaf houttuynia herb, 2 parts of thunberg fritillary bulb, 2 parts of platycodon root, 5 parts of officinal magnolia bark, 2 parts of blackberry lily, 5 parts of indigowoad root, 5 parts of virgate wormwood herb, 5 parts of talcum, 5 parts of common clematis stem, 5 parts of grassleaf sweelflag rhizome, 5 parts of stir-fried hyacinth bean and 1 part of liquorice.
The preparation method comprises the following steps: weighing the raw materials according to the proportion, adding 7.8 times of water, decocting and extracting for 2 times, each time for 33min, filtering, concentrating the filtrate until the relative density is not lower than 1.06 (70 ℃), refrigerating and standing for 24-72 h, pouring and sterilizing to obtain the solution.
EXAMPLE 5 preparation of the medicament of the invention
The formula comprises the following components: 25 parts of wine baical skullcap root, 25 parts of cardamom, 18 parts of honeysuckle, 25 parts of weeping forsythia, 25 parts of wrinkled gianthyssop herb, 18 parts of peppermint, 25 parts of heartleaf houttuynia herb, 18 parts of thunberg fritillary bulb, 18 parts of platycodon root, 25 parts of officinal magnolia bark, 18 parts of blackberry lily, 25 parts of indigowoad root, 25 parts of virgate wormwood herb, 25 parts of talcum, 25 parts of common clematis stem, 25 parts of grassleaf sweelflag rhizome, 25 parts of stir-fried hyacinth bean and 9 parts of liquorice.
The preparation method comprises the following steps: weighing the raw materials according to the proportion, adding 7.8 times of water, decocting and extracting for 2 times, each time for 33min, filtering, concentrating the filtrate until the relative density is not lower than 1.06 (70 ℃), refrigerating and standing for 24-72 h, pouring and sterilizing to obtain the solution.
The beneficial effects of the present invention are described below by test examples
Test example 1 clinical efficacy of the Chinese medicinal composition of the present invention
1. Clinical data
The test group selects 70 cases of cough caused by damp-heat invading the lung or accompanied by discomfort of the throat, chest distress, epigastric fullness, aversion to cold, heaviness of the head and body, hypodynamia and the like which are collected and treated by the clinic of the traditional Chinese medicine hospital in south China filling city in 1 month to 2022, and all patients are checked and confirmed to be damp-heat invading the lung. 36 men and 34 women; age 22-68 years, average age (50.6.+ -. 5.2) years.
1.1 diagnostic criteria
1.1.1 diagnostic criteria
Cough with sound, or cough with itching throat. Cough due to exogenous pathogenic factors, and acute onset of disease may be accompanied by exterior syndrome such as cold and heat. Cough due to internal injury can be accompanied with asthma due to repeated attack of exogenous pathogenic factors with longer disease course. The total number of blood leukocytes and neutrophils increase in the acute phase. Auscultation of both lungs may be audible and the breathing sounds thickened, or accompanied by dry and wet rotten sounds. X-ray examination of lung, normal or thickening of lung texture.
1.1.2 Condition Classification of syndromes
Cough syndrome in Chinese people's republic of China, which is the traditional Chinese medicine industry standard for diagnosing traditional Chinese medicine disease, is characterized by wind-cold attacking the lung, wind-heat attacking the lung, dryness-evil damaging the lung, phlegm-heat obstructing the lung, liver-fire attacking the lung, phlegm-dampness obstructing the lung, lung yin deficiency and lung qi deficiency. The clinically involved damp-heat invading lung consists of the various symptoms, and is specifically composed of the following symptoms:
wind-heat invading the lung: cough with coarse breath, sticky or yellow phlegm, sore throat, cough with hoarseness, fever, slight aversion to wind and cold, and slight thirst. A red tongue tip, a thin white or yellow coating and a superficial and rapid pulse.
Dryness injures the lung: dry cough with little phlegm, difficult expectoration, dry nasopharynx and dry mouth. A red tongue tip, a thin and yellow coating, little body fluid and a thready and rapid pulse.
Phlegm-heat obstructing the lung: cough with coarse breath, thick and yellow sputum, dysphoria with dry mouth. A red tongue with yellow and greasy coating and a slippery and rapid pulse.
Phlegm dampness accumulating in the lung: the cough with heavy and turbid sound, profuse and white phlegm, severe morning sickness, chest oppression and epigastric fullness and anorexia. A white and greasy coating and a slippery pulse.
1.2 inclusion criteria
Cases meeting the 1.1 diagnostic criteria were included.
2. Therapeutic method
Test group: the pharmaceutical of the composition of the present invention is administered.
The specific administration method is as follows: the composition of the composition example 1 is decocted and extracted, 7.8 times of water by weight of the composition is added, the decoction is carried out for 33 minutes, the filtration is carried out, the two filtrates are combined, the concentration is carried out to a proper amount (about 1200 ml), the oral administration is carried out, one dose is carried out for two days, the dosage is 200ml each time, the content of the crude drug is 23.5g, and the curative effect statistics is carried out after two weeks of continuous administration.
3. Observation of curative effect
3.1 Standard of efficacy
Clinical efficacy standards according to the traditional Chinese medical science evidence diagnosis efficacy standard (ZY/T001.1-94) of the people's republic of China can be divided into 3 classes:
(1) and (3) curing: the clinical signs of cough disappeared; cough with internal injury is clinically cured by more than two weeks of non-originators.
(2) Improvement: cough is relieved, and sputum is reduced.
(3) The method is characterized in that: the symptoms were not significantly altered.
3.2 therapeutic Effect
As shown in the table:
conclusion of the test: the traditional Chinese medicine has the advantages that 70 patients treated by the traditional Chinese medicine are cured by 58 cases, 12 cases are improved, 0 cases are not effective, the cure rate is 82.86%, the effective rate reaches 100%, no adverse reaction occurs at present, and the result shows that the traditional Chinese medicine has reasonable formula, has obvious curative effect on cough caused by damp-heat invading the lung, and is worthy of clinical popularization and application.
Claims (8)
1. A traditional Chinese medicine composition for treating cough caused by damp-heat invading lung is characterized in that: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
5-25 parts of wine baical skullcap root, 5-25 parts of cardamom, 2-18 parts of honeysuckle, 5-25 parts of weeping forsythia, 5-25 parts of wrinkled gianthyssop herb, 2-18 parts of peppermint, 5-25 parts of heartleaf houttuynia herb, 2-18 parts of thunberg fritillary bulb, 2-18 parts of platycodon root, 5-25 parts of officinal magnolia bark, 2-18 parts of blackberry lily, 5-25 parts of radix isatidis, 5-25 parts of virgate wormwood herb, 5-25 parts of talcum, 5-25 parts of common monkshood mother root, 5-25 parts of grassleaf sweetflag rhizome, 5-25 parts of stir-fried hyacinth bean and 1-9 parts of liquorice.
2. The traditional Chinese medicine composition according to claim 1, wherein: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
10-20 parts of wine baical skullcap root, 10-20 parts of cardamon, 5-15 parts of honeysuckle, 10-20 parts of weeping forsythia, 10-20 parts of wrinkled gianthyssop herb, 5-15 parts of peppermint, 10-20 parts of heartleaf houttuynia herb, 5-15 parts of thunberg fritillary bulb, 5-15 parts of platycodon root, 10-20 parts of officinal magnolia bark, 5-15 parts of blackberry lily, 10-20 parts of indigowoad root, 10-20 parts of virgate wormwood herb, 10-20 parts of talcum, 10-20 parts of common monkshood mother root, 10-20 parts of grassleaf sweetflag rhizome, 10-20 parts of stir-fried hyacinth bean and 1-6 parts of liquorice.
3. The traditional Chinese medicine composition according to claim 2, wherein: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
15 parts of wine baical skullcap root, 15 parts of cardamom, 10 parts of honeysuckle, 15 parts of weeping forsythia, 15 parts of wrinkled gianthyssop herb, 10 parts of peppermint, 15 parts of heartleaf houttuynia herb, 10 parts of thunberg fritillary bulb, 10 parts of platycodon root, 15 parts of officinal magnolia bark, 10 parts of blackberry lily, 15 parts of Indigowoad root, 15 parts of virgate wormwood herb, 15 parts of talcum, 15 parts of common clematis stem, 15 parts of grassleaf sweelflag rhizome, 15 parts of stir-fried hyacinth bean and 3 parts of liquorice.
4. The traditional Chinese medicine composition according to any one of claims 1-3, which is characterized in that: the preparation is prepared by taking medicinal powder of the raw materials or water or organic solvent extracts of the raw materials as active ingredients and adding pharmaceutically acceptable auxiliary materials.
5. The traditional Chinese medicine composition according to claim 4, wherein: the preparation is an oral preparation; the oral preparation is mixture, granule, capsule, tablet, oral liquid or syrup.
6. The method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 5, which is characterized in that: it comprises the following steps:
(1) Weighing the raw materials according to the proportion of claim 1;
(2) Extracting the raw materials with water, filtering the extractive solution, concentrating, standing, packaging, and sterilizing.
7. The method of manufacturing according to claim 6, wherein: the times of extraction in the step (2) are 2 times, the extraction time is 33 minutes each time, and the water adding multiple is 7.8 times; the concentration is to be carried out until the relative density at 70 ℃ is not lower than 1.06; the standing is refrigeration standing.
8. The use of the traditional Chinese medicine composition according to any one of claims 1-6 in preparing a medicament for treating cough caused by damp-heat invading lung.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103463536A (en) * | 2013-08-26 | 2013-12-25 | 荣成市科学技术情报研究所 | Traditional Chinese medicine composition for treating wind-heat affecting lung |
| CN113368198A (en) * | 2021-07-13 | 2021-09-10 | 哈尔滨珍宝制药有限公司 | Pharmaceutical composition for treating wind-heat affecting lung and preparation method and application thereof |
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| CN103463536A (en) * | 2013-08-26 | 2013-12-25 | 荣成市科学技术情报研究所 | Traditional Chinese medicine composition for treating wind-heat affecting lung |
| CN113368198A (en) * | 2021-07-13 | 2021-09-10 | 哈尔滨珍宝制药有限公司 | Pharmaceutical composition for treating wind-heat affecting lung and preparation method and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| 甘露消毒丹加减治疗慢性咽炎(湿热型)临床观察;路军章等;中国中医药信息杂志;-;第13卷(第10期);80-81 * |
| 甘露消毒丹治疗儿科诸疾验案;马文红;中医儿科杂志;-;第4卷(第06期);35-37 * |
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