CN116355753A - Biological product extraction instrument - Google Patents
Biological product extraction instrument Download PDFInfo
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- CN116355753A CN116355753A CN202310338545.2A CN202310338545A CN116355753A CN 116355753 A CN116355753 A CN 116355753A CN 202310338545 A CN202310338545 A CN 202310338545A CN 116355753 A CN116355753 A CN 116355753A
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- plate
- biological product
- movable plate
- motor
- electromagnet disc
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- 238000000605 extraction Methods 0.000 title claims abstract description 25
- 239000011324 bead Substances 0.000 claims abstract description 31
- 230000001105 regulatory effect Effects 0.000 claims description 12
- 230000001276 controlling effect Effects 0.000 claims description 3
- 238000003825 pressing Methods 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 abstract description 19
- 108020004707 nucleic acids Proteins 0.000 abstract description 19
- 150000007523 nucleic acids Chemical class 0.000 abstract description 19
- 238000002360 preparation method Methods 0.000 abstract description 8
- 206010011409 Cross infection Diseases 0.000 abstract description 5
- 206010029803 Nosocomial infection Diseases 0.000 abstract description 5
- 230000000379 polymerizing effect Effects 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 51
- 238000000034 method Methods 0.000 description 12
- 238000004140 cleaning Methods 0.000 description 6
- 239000006185 dispersion Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 2
- 238000005336 cracking Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 238000010557 suspension polymerization reaction Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000002457 bidirectional effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 239000003398 denaturant Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 238000007886 magnetic bead extraction Methods 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
- C12N15/1013—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by using magnetic beads
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Abstract
The invention discloses a biological product extractor, and belongs to the technical field of nucleic acid extraction equipment. The biological product extraction instrument comprises a bearing unit and a horizontally adjustable eccentric vibration module, wherein the bearing unit comprises an electromagnet disc, a temperature adjusting element and a first movable plate which are sequentially arranged from top to bottom, the electromagnet disc is used for placing a type plate containing magnetic beads, and the electromagnet disc is electrically connected with a control module and used for controlling the magnetic phase of the electromagnet disc; the temperature adjusting element is used for adjusting the temperature of the type plate above the electromagnetic disc; the output end of the horizontal adjustable eccentric vibration module is connected with the first movable plate and is used for shaking the type plate above the electromagnet disc. The invention has the functions of adjusting the magnetic field module for polymerizing and dispersing the magnetic beads, shaking uniformly and adjusting the temperature, avoids adding and taking out biological products among various devices, reduces the cross infection of the biological products, and improves the preparation efficiency and quality of the biological products.
Description
Technical Field
The invention relates to the technical field of nucleic acid extraction equipment, in particular to a biological product extractor.
Background
The magnetic bead method nucleic acid extraction is a novel nucleic acid extraction technology with nano biological magnetic beads as carriers, nucleic acid molecules can be specifically identified and combined with silicon hydroxyl groups on the surfaces of the magnetic beads, and the nucleic acid molecules are aggregated or dispersed under the action of an external magnetic field, so that the manual operation procedures of centrifugation, supernatant extraction and the like in the traditional nucleic acid extraction process are thoroughly eliminated, and the automatic extraction of nucleic acid is realized. The method is widely applied to various fields such as clinical disease diagnosis, blood transfusion safety, forensic identification, environmental microorganism detection, food safety detection, molecular biology research and the like.
The magnetic bead method nucleic acid extraction process generally comprises: the method comprises four main steps of cracking, combining, washing and eluting, wherein each step can be realized by a plurality of different methods singly or jointly, the cell cracking liquid in the magnetic bead method is a protein denaturant, the cells of animals, plants and pathogenic microorganisms can be cracked, the protein combined with nucleic acid is denatured, the nucleic acid is released in a free way, the magnetic beads can specifically adsorb the nucleic acid, impurities such as proteins except the nucleic acid are removed through washing, and the nucleic acid solution with high purity and concentration can be obtained by dissociating the nucleic acid adsorbed on the magnetic beads through the eluent, and can be used for PCR amplification, enzyme digestion, molecular hybridization and the like.
However, the whole process of shaking, rinsing, and cleaning the magnetic beads to obtain, for example, nucleic acid products requires many steps, and is borne by complex mechanical structures and a plurality of modules in an automated process, so that not only is there a risk of biological cross-contamination, but also the preparation efficiency of biological products is reduced.
For this reason, it is desirable to provide a biological product extractor to solve the above-mentioned problems.
Disclosure of Invention
The invention aims to provide a biological product extractor which has the functions of adjusting a magnetic field module for polymerizing and dispersing magnetic beads, shaking uniformly and adjusting temperature, avoids adding and taking out biological products among various devices, reduces cross infection of the biological products and improves the preparation efficiency and quality of the biological products.
In order to achieve the above object, the following technical scheme is provided:
a biological product extractor comprising:
the bearing unit comprises an electromagnet disc, a temperature regulating element and a first movable plate which are sequentially arranged from top to bottom, wherein the electromagnet disc is used for placing a type plate containing magnetic beads, and the electromagnet disc is electrically connected with the control module and used for controlling the magnetic phase of the electromagnet disc; the temperature adjusting element is used for adjusting the temperature of the type plate above the electromagnet disc;
the output end of the horizontal adjustable eccentric vibration module is connected with the first movable plate and is used for shaking the type plate above the electromagnet disc.
As the alternative scheme of biological product extraction appearance, the adjustable eccentric vibration module of level includes motor and the eccentric shaft that sets up along vertical direction, the output shaft of motor is fixed to be provided with the installation piece, set up along radial first bar hole that extends on the installation piece, the upper end of eccentric shaft with first movable plate rotates to be connected, the lower extreme of eccentric shaft with first bar hole is connected, just the axis of eccentric shaft with the axis non-coaxial line setting of the output shaft of motor.
As an alternative of the biological product extractor, the side wall of the mounting block is provided with a second bar-shaped hole, the second bar-shaped hole is communicated with the first bar-shaped hole, and a fastener penetrates through the second bar-shaped hole to be connected with the lower end of the eccentric shaft.
As an alternative scheme of the biological product extractor, a bearing pressing plate is arranged on an output shaft of the motor, and a threaded hole is formed in the mounting block and used for mounting the balancing weight.
As the alternative scheme of biological product extraction appearance, be provided with the organic board on the casing of motor, the upper surface of machine board is provided with along the first linear guide rail of first direction extension, bear the weight of the unit still include the second movable plate, the lower terminal surface of second movable plate slide set up in on the first linear guide rail, the up end of second movable plate is provided with along the second linear guide rail of second direction extension, the lower terminal surface of first movable plate slide set up in on the second linear guide rail.
As an alternative scheme of the biological product extraction instrument, the upper surface of the machine plate is parallel and is provided with two first linear guide rails at intervals, and the upper end surface of the second movable plate is parallel and is provided with two second linear guide rails at intervals.
As an alternative scheme of the biological product extractor, the second movable plate is provided with an avoidance hole for passing through an output shaft of the motor.
As an alternative scheme of the biological product extraction instrument, the biological product extraction instrument further comprises a bottom plate, wherein the bottom of the motor is arranged on the bottom plate, a circuit board module is arranged on the bottom plate, and the circuit board module is electrically connected with the temperature regulating element.
As an alternative to the biological product extractor, a heat shield is provided between the temperature adjusting element and the first movable plate.
As alternatives to the biological product extractor, the types of plates include 96 shallow plates, 24 plates, 48 plates, and 96 deep plates. .
Compared with the prior art, the invention has the beneficial effects that:
the biological product extractor provided by the invention has the advantages that the type plate containing the magnetic beads and the culture solution is arranged on the electromagnetic disc, and the electromagnetic disc can realize the adjustment between magnetic phases so as to reflect the adsorption and release of the magnetic beads, thereby realizing the two states of enrichment and dispersion of the magnetic beads and the control of matrix, realizing the modulation of the magnetic phases of different magnetic bead separation types, and being compatible with various templates; mapping to biological products, namely removing nonspecific attachments in different culture solutions, enriching the attachments to magnetic beads for further cleaning until the cleaning step is finished, and releasing the biological products from the magnetic beads to realize solid-liquid separation.
The output end of the horizontally adjustable eccentric vibration module is connected with the first movable plate, and the two-way adjustment of the amplitude and the vibration frequency can be compatible with various templates and shake the templates above the electromagnetic disc, so that the culture solution is fully and uniformly mixed without any external machinery.
The temperature regulating element of the biological product extractor provided by the invention can realize rapid temperature rise and temperature reduction in different periods, realize high-efficiency change of time resolution of temperature, and combine with magnetic bead rinsing and temperature rise to lead biological products (nucleic acid-DNA) to be separated from magnetic beads and improve recovery efficiency.
In summary, the biological product extractor provided by the invention has the functions of adjusting the magnetic field module for magnetic bead polymerization dispersion, shaking up by vibration and adjusting temperature, avoids adding and taking out biological products among various devices, reduces cross infection of the biological products, and improves the preparation efficiency and quality of the biological products.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following description will briefly explain the drawings needed in the description of the embodiments of the present invention, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to the contents of the embodiments of the present invention and these drawings without inventive effort for those skilled in the art.
FIG. 1 is a front view of a biological product extractor in an embodiment of the present invention;
FIG. 2 is an enlarged view of a portion of FIG. 1 at A;
FIG. 3 is a cross-sectional view of a biological product extractor in an embodiment of the present invention;
FIG. 4 is an exploded view of a biological product extractor according to an embodiment of the present invention;
fig. 5 is an assembly schematic of a motor, eccentric shaft and dynamic balance weight disc in an embodiment of the invention.
Reference numerals:
1. an electromagnet disc; 2. a temperature adjusting element; 3. a first movable plate; 4. a class plate; 5. a motor; 6. an eccentric shaft; 7. a mounting block; 71. a first bar-shaped hole; 72. a second bar-shaped hole; 73. a threaded hole; 8. a fastener; 9. a bearing pressing plate; 10. a machine plate; 11. a first linear guide rail; 12. a second movable plate; 121. avoidance holes; 13. a second linear guide rail; 14. a bottom plate; 15. a circuit board module; 16. a heat insulating plate; 17. a first slider; 18. a second slider; 19. and (3) a bearing.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments of the present invention. The components of the embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the invention, as presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It should be noted that: like reference numerals and letters denote like items in the following figures, and thus once an item is defined in one figure, no further definition or explanation thereof is necessary in the following figures.
In the description of the present invention, it should be noted that, directions or positional relationships indicated by terms such as "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., are directions or positional relationships based on those shown in the drawings, or are directions or positional relationships conventionally put in use of the inventive product, are merely for convenience of describing the present invention and simplifying the description, and are not indicative or implying that the apparatus or element to be referred to must have a specific direction, be configured and operated in a specific direction, and thus should not be construed as limiting the present invention. Furthermore, the terms "first," "second," "third," and the like are used merely to distinguish between descriptions and should not be construed as indicating or implying relative importance. In the description of the present invention, unless otherwise indicated, the meaning of "a plurality" is two or more.
In the description of the present invention, it should also be noted that, unless explicitly specified and limited otherwise, the terms "disposed", "connected" and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected or integrally connected; either mechanically or electrically. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.
In the present invention, unless expressly stated or limited otherwise, a first feature "above" or "below" a second feature may include both the first and second features being in direct contact, as well as the first and second features not being in direct contact but being in contact with each other through additional features therebetween. Moreover, a first feature being "above," "over" and "on" a second feature includes the first feature being directly above and obliquely above the second feature, or simply indicating that the first feature is higher in level than the second feature. The first feature being "under", "below" and "beneath" the second feature includes the first feature being directly under and obliquely below the second feature, or simply means that the first feature is less level than the second feature.
Embodiments of the present invention are described in detail below, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to like or similar elements or elements having like or similar functions throughout. The embodiments described below by referring to the drawings are illustrative only and are not to be construed as limiting the invention.
On the way of developing life science automation, the method of magnetic bead extraction is widely applied to all automation equipment for extracting life products as a means for cell sorting, protein purification and nucleic acid enrichment, and is an essential and core automation module in the field.
However, the whole process of shaking, rinsing, cleaning, and obtaining, for example, nucleic acid products, of the magnetic beads requires many steps, and is carried by complicated mechanical structures and a plurality of modules in an automated process, and the flux and the preparation efficiency thereof remain unsolved. There is a discrepancy between the efficiency of the preparation process and the quality of the biological product (protein, nucleic acid, cell) obtained.
In order to avoid the addition and removal of biological products between various devices, not only reduce cross-infection of biological products, but also improve the preparation efficiency and quality of biological products, the present embodiment provides a biological product extraction apparatus, and details of the present embodiment are described below in detail with reference to fig. 1 to 5. In this embodiment, the biological product extractor includes a carrier unit and a horizontally adjustable eccentric vibration module. The bearing unit comprises an electromagnet disc 1, a temperature regulating element 2 and a first movable plate 3 which are sequentially arranged from top to bottom, wherein the electromagnet disc 1 is used for placing a type plate 4 containing magnetic beads, and the electromagnet disc 1 is electrically connected with the control module and used for controlling the magnetic phase of the electromagnet disc 1; the temperature adjusting element 2 is used to adjust the temperature of the type plate 4 above the electromagnet disc 1. The output end of the horizontal adjustable eccentric vibration module is connected with the first movable plate 3 and is used for shaking the type plate 4 above the electromagnet disc 1. The type of plate 4 mentioned in this embodiment includes 96 shallow plates, 24 plates, 48 plates, 96 deep plates, and the like. Wherein, due to the different sizes of the type plates 4 of different specifications, when the 24-orifice plate and the 48-orifice plate are required to be installed, the upper electromagnet disc 1 needs to be replaced or adapted.
In short, the biological product extractor provided by the invention has the advantages that the type plate 4 containing magnetic beads and culture solution is placed on the electromagnet disc 1, and the electromagnet disc 1 can realize adjustment between magnetic phases so as to reflect the adsorption and release of the magnetic beads, thereby realizing the two states of enrichment and dispersion of the magnetic beads and the control of matrix, realizing the modulation of the magnetic phases of different magnetic beads in separate types, and being compatible with various types of plates 4; mapping to biological products, namely removing nonspecific attachments in different culture solutions, enriching the attachments to magnetic beads for further cleaning until the cleaning step is finished, and releasing the biological products from the magnetic beads to realize solid-liquid separation. The output end of the horizontal adjustable eccentric vibration module is connected with the first movable plate 3, and through the bidirectional adjustment of the amplitude and the vibration frequency, the horizontal adjustable eccentric vibration module can be compatible with various types of plates 4 and shake the type plates 4 above the electromagnet plates 1, so that the culture solution is fully uniformly mixed, and no external machine is needed. The temperature regulating element 2 can realize rapid temperature rise and temperature reduction in different periods, realize high-efficiency change of time resolution of temperature, and combine with magnetic bead rinsing and temperature rise to enable biological products (nucleic acid-DNA) to be separated from the magnetic beads, so that recovery efficiency is improved. In summary, the biological product extractor provided by the invention has the functions of adjusting the magnetic field module for magnetic bead polymerization dispersion, shaking up by vibration and adjusting temperature, avoids adding and taking out biological products among various devices, reduces cross infection of the biological products, and improves the preparation efficiency and quality of the biological products.
Further, the horizontally adjustable eccentric vibration module comprises a motor 5 and an eccentric shaft 6 which are arranged along the vertical direction, an output shaft of the motor 5 is fixedly provided with a mounting block 7, a first strip-shaped hole 71 which extends along the radial direction is formed in the mounting block 7, the upper end of the eccentric shaft 6 is rotationally connected with the first movable plate 3, the lower end of the eccentric shaft 6 is connected with the first strip-shaped hole 71, and the axis of the eccentric shaft 6 and the axis of the output shaft of the motor 5 are arranged in a non-coaxial line. The amplitude and frequency of the eccentric vibrations of the type plate 4 are regulated by radially regulating the position of the lower end of the eccentric shaft 6 in the first bar-shaped hole 71 and the rotation speed of the motor 5. Two threaded holes 73 in the mounting block 7 can be used for the mounting of the balancing weight.
Further, the side wall of the mounting block 7 is provided with a second bar-shaped hole 72, the second bar-shaped hole 72 is communicated with the first bar-shaped hole 71, a fastener 8 passes through the second bar-shaped hole 72 to be connected with the lower end of the eccentric shaft 6, and the fastener 8 can be, but is not limited to, a pin, a bolt or the like. In this embodiment, the eccentric shaft 6 is firmly fitted to the eccentric position of the mounting block 7 by a pin passing through the second bar-shaped hole 72 to be partially connected with the eccentric shaft 6 located in the first bar-shaped hole 71.
Further, a bearing press plate 9 is mounted on the output shaft of the motor 5, the bearing press plate 9 being adapted to be mounted in a position defining a bearing 19. The threaded hole 73 on the mounting block 7 can be used for mounting the balancing weight according to actual conditions, so that the rotation influence of the mounting block 7 and the eccentric shaft 6 on the output shaft of the motor 5 is reduced, and the output shaft of the motor 5 is dynamically balanced in a rotating state.
Further, an organic board 10 is disposed on the casing of the motor 5, a first linear guide 11 extending along a first direction (X direction) is disposed on the upper surface of the organic board 10, the bearing unit further includes a second movable board 12, a second slider 18 fixedly disposed on a lower end surface of the second movable board 12 is slidably disposed on the first linear guide 11, a second linear guide 13 extending along a second direction (Y direction) is disposed on an upper end surface of the second movable board 12, and a first slider 17 fixedly disposed on a lower end surface of the first movable board 3 is slidably disposed on the second linear guide 13.
Specifically, the upper surface of the machine plate 10 is parallel and provided with two first linear guide rails 11 at intervals, and the upper end surface of the second movable plate 12 is parallel and provided with two second linear guide rails 13 at intervals. The second movable plate 12 is provided with a relief hole 121 for passing through the output shaft of the motor 5 to avoid structural interference.
Further, the biological product extraction apparatus further comprises a bottom plate 14, and the bottom of the motor 5 is mounted on the bottom plate 14. The larger surface area of the bottom plate 14 facilitates the smooth placement of the biological product extractor onto the laboratory table. The circuit board module 15 is mounted on the bottom plate 14, and the circuit board module 15 is electrically connected with the temperature adjusting element 2, so that the temperature adjusting element 2 can heat or refrigerate.
Further, a heat insulation plate 16 is arranged between the temperature adjusting element 2 and the first movable plate 3, so that the temperature can only heat or refrigerate the type plate 4 on the electromagnet disc 1 upwards, the downward transmission of the temperature is isolated, and the temperature influence of the temperature adjusting element 2 on the first movable plate 3 is reduced.
Note that the above is only a preferred embodiment of the present invention and the technical principle applied. It will be understood by those skilled in the art that the present invention is not limited to the particular embodiments described herein, but is capable of various obvious changes, rearrangements and substitutions as will now become apparent to those skilled in the art without departing from the scope of the invention. Therefore, while the invention has been described in connection with the above embodiments, the invention is not limited to the embodiments, but may be embodied in many other equivalent forms without departing from the spirit or scope of the invention, which is set forth in the following claims.
Claims (10)
1. A biological product extractor, comprising:
the bearing unit comprises an electromagnet disc (1), a temperature regulating element (2) and a first movable plate (3) which are sequentially arranged from top to bottom, wherein the electromagnet disc (1) is used for placing a type plate (4) containing magnetic beads, and the electromagnet disc (1) is electrically connected with the control module and used for controlling the magnetic phase of the electromagnet disc (1); the temperature regulating element (2) is used for regulating the temperature of the type plate (4) above the electromagnet disc (1);
the output end of the horizontal adjustable eccentric vibration module is connected with the first movable plate (3) and is used for shaking the type plate (4) above the electromagnet disc (1).
2. The biological product extraction instrument according to claim 1, wherein the horizontally adjustable eccentric vibration module comprises a motor (5) and an eccentric shaft (6) which are arranged along the vertical direction, an output shaft of the motor (5) is fixedly provided with a mounting block (7), a first bar-shaped hole (71) extending along the radial direction is formed in the mounting block (7), the upper end of the eccentric shaft (6) is rotationally connected with the first movable plate (3), the lower end of the eccentric shaft (6) is connected with the first bar-shaped hole (71), and the axis of the eccentric shaft (6) and the axis of the output shaft of the motor (5) are arranged in a non-coaxial line.
3. The biological product extraction instrument according to claim 2, characterized in that the side wall of the mounting block (7) is provided with a second bar-shaped hole (72), the second bar-shaped hole (72) is communicated with the first bar-shaped hole (71), and a fastener (8) is connected with the lower end of the eccentric shaft (6) through the second bar-shaped hole (72).
4. The biological product extractor according to claim 2, characterized in that the output shaft of the motor (5) is provided with a bearing pressing plate (9), and the mounting block (7) is provided with a threaded hole (73) for mounting a balancing weight.
5. The biological product extraction instrument according to claim 2, characterized in that an organic plate (10) is arranged on a casing of the motor (5), a first linear guide rail (11) extending along a first direction is arranged on an upper surface of the organic plate (10), the bearing unit further comprises a second movable plate (12), a lower end surface of the second movable plate (12) is slidably arranged on the first linear guide rail (11), a second linear guide rail (13) extending along a second direction is arranged on an upper end surface of the second movable plate (12), and a lower end surface of the first movable plate (3) is slidably arranged on the second linear guide rail (13).
6. The biological product extraction instrument according to claim 5, wherein the upper surface of the machine plate (10) is parallel and provided with two first linear guide rails (11) at intervals, and the upper end surface of the second movable plate (12) is parallel and provided with two second linear guide rails (13) at intervals.
7. The biological product extraction apparatus according to claim 5, characterized in that the second moving plate (12) is provided with a relief hole (121) for passing through the output shaft of the motor (5).
8. The biological product extraction instrument according to claim 2, further comprising a base plate (14), wherein the bottom of the motor (5) is mounted on the base plate (14), and wherein a circuit board module (15) is mounted on the base plate (14), and wherein the circuit board module (15) is electrically connected to the temperature regulating element (2).
9. The biological product extraction instrument according to any one of claims 1-8, characterized in that a heat shield (16) is arranged between the temperature regulating element (2) and the first moving plate (3).
10. The biological product extractor according to any of the claims 1-8, characterized in that the type plate (4) comprises a 96 shallow plate, a 24 plate, a 48 plate and a 96 deep plate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310338545.2A CN116355753A (en) | 2023-03-31 | 2023-03-31 | Biological product extraction instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310338545.2A CN116355753A (en) | 2023-03-31 | 2023-03-31 | Biological product extraction instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116355753A true CN116355753A (en) | 2023-06-30 |
Family
ID=86930843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310338545.2A Pending CN116355753A (en) | 2023-03-31 | 2023-03-31 | Biological product extraction instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116355753A (en) |
-
2023
- 2023-03-31 CN CN202310338545.2A patent/CN116355753A/en active Pending
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