CN1163127A - 葛根素及其提取方法 - Google Patents
葛根素及其提取方法 Download PDFInfo
- Publication number
- CN1163127A CN1163127A CN 96115754 CN96115754A CN1163127A CN 1163127 A CN1163127 A CN 1163127A CN 96115754 CN96115754 CN 96115754 CN 96115754 A CN96115754 A CN 96115754A CN 1163127 A CN1163127 A CN 1163127A
- Authority
- CN
- China
- Prior art keywords
- puerarin
- crude product
- water
- extracting method
- column chromatography
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 title claims abstract description 60
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 title claims abstract description 60
- 238000000034 method Methods 0.000 title claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- 229920002647 polyamide Polymers 0.000 claims abstract description 20
- 239000004952 Polyamide Substances 0.000 claims abstract description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000001035 drying Methods 0.000 claims abstract description 14
- 239000000284 extract Substances 0.000 claims abstract description 10
- 238000000605 extraction Methods 0.000 claims abstract description 10
- 238000007670 refining Methods 0.000 claims abstract description 8
- 238000010828 elution Methods 0.000 claims abstract description 6
- 239000000463 material Substances 0.000 claims abstract description 4
- 239000012043 crude product Substances 0.000 claims description 32
- 238000004440 column chromatography Methods 0.000 claims description 16
- 238000002425 crystallisation Methods 0.000 claims description 13
- 230000008025 crystallization Effects 0.000 claims description 13
- 238000002386 leaching Methods 0.000 claims description 12
- 239000012141 concentrate Substances 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 8
- 238000004587 chromatography analysis Methods 0.000 claims description 7
- 239000003480 eluent Substances 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 6
- 230000001476 alcoholic effect Effects 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 4
- 239000008367 deionised water Substances 0.000 claims description 4
- 229910021641 deionized water Inorganic materials 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 238000000746 purification Methods 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 239000006286 aqueous extract Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- 238000012869 ethanol precipitation Methods 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 238000011084 recovery Methods 0.000 claims description 2
- 238000001953 recrystallisation Methods 0.000 claims description 2
- 238000001694 spray drying Methods 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 239000002594 sorbent Substances 0.000 claims 1
- -1 crushing Substances 0.000 abstract description 2
- 238000001556 precipitation Methods 0.000 abstract description 2
- 241000219780 Pueraria Species 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 description 4
- 208000024172 Cardiovascular disease Diseases 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 206010020772 Hypertension Diseases 0.000 description 2
- 244000046146 Pueraria lobata Species 0.000 description 2
- 235000010575 Pueraria lobata Nutrition 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 206010037844 rash Diseases 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 206010028836 Neck pain Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Images
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN96115754A CN1061344C (zh) | 1996-04-25 | 1996-04-25 | 葛根素及其提取方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN96115754A CN1061344C (zh) | 1996-04-25 | 1996-04-25 | 葛根素及其提取方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1163127A true CN1163127A (zh) | 1997-10-29 |
CN1061344C CN1061344C (zh) | 2001-01-31 |
Family
ID=5122976
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN96115754A Expired - Lifetime CN1061344C (zh) | 1996-04-25 | 1996-04-25 | 葛根素及其提取方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1061344C (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1299694C (zh) * | 2005-03-09 | 2007-02-14 | 董诗文 | 一种解酒保肝的黄酮组合物及其用途 |
CN101560201B (zh) * | 2009-05-15 | 2011-07-20 | 卓宇哲 | 从葛根中萃取葛根素及多种医药成分的工艺 |
CN103224491A (zh) * | 2013-05-22 | 2013-07-31 | 天津道谷生物科技有限公司 | 以水为溶媒提取高纯葛根素的方法 |
CN108610335A (zh) * | 2016-12-13 | 2018-10-02 | 丹阳市香逸林果专业合作社 | 一种葛根素的提取工艺 |
CN111072646A (zh) * | 2019-12-27 | 2020-04-28 | 四川省玉鑫药业有限公司 | 一种葛根素精制的方法 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1314404C (zh) * | 2004-06-02 | 2007-05-09 | 冯成铨 | 一种具有保健预防作用的保健霜及制备方法 |
CN103371342A (zh) * | 2012-04-28 | 2013-10-30 | 殷庆章 | 一种葛根萃取的方法 |
-
1996
- 1996-04-25 CN CN96115754A patent/CN1061344C/zh not_active Expired - Lifetime
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1299694C (zh) * | 2005-03-09 | 2007-02-14 | 董诗文 | 一种解酒保肝的黄酮组合物及其用途 |
CN101560201B (zh) * | 2009-05-15 | 2011-07-20 | 卓宇哲 | 从葛根中萃取葛根素及多种医药成分的工艺 |
CN103224491A (zh) * | 2013-05-22 | 2013-07-31 | 天津道谷生物科技有限公司 | 以水为溶媒提取高纯葛根素的方法 |
CN108610335A (zh) * | 2016-12-13 | 2018-10-02 | 丹阳市香逸林果专业合作社 | 一种葛根素的提取工艺 |
CN111072646A (zh) * | 2019-12-27 | 2020-04-28 | 四川省玉鑫药业有限公司 | 一种葛根素精制的方法 |
Also Published As
Publication number | Publication date |
---|---|
CN1061344C (zh) | 2001-01-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1066055C (zh) | 从竹叶中提取黄酮类化合物浸膏或粉剂的生产方法 | |
CN101704867A (zh) | 一种柚皮苷或橙皮苷的制备方法 | |
CN101619107A (zh) | 黄芪多糖的提取方法 | |
CN102526315A (zh) | 一种荔枝核有效部位群提取物的制备方法 | |
CN1061344C (zh) | 葛根素及其提取方法 | |
CN1393443A (zh) | 用显齿蛇葡萄植物生产二氢杨梅树皮素的方法 | |
CN105732741A (zh) | 紫苏叶提取花色苷和熊果酸的方法 | |
CN1057093C (zh) | 一种提取葛根素的方法 | |
CN1082409A (zh) | 医用天然水蛭素的提取方法 | |
CN114796070A (zh) | 一种具有修复功能抗炎抗过敏疗伤花的组合物及制备方法 | |
CN1057398A (zh) | 藿香正气液体口服制剂的制备方法 | |
CN1313458C (zh) | 桑枝总黄酮提取方法 | |
CN1060050C (zh) | 一种加味双黄连药剂及其制备方法 | |
CN1150027A (zh) | 一种提取白菊花有效成分的方法 | |
CN1199676C (zh) | 一种清热解毒消肿,抗菌抗病毒消炎的兽用中草药注射液 | |
CN1154849A (zh) | 制取葛根素的方法 | |
CN1032405C (zh) | 一种灯盏花注射液制备工艺 | |
CN1283634C (zh) | 毛喉鞘蕊花提取物及其制备方法和用途 | |
CN110295086A (zh) | 一种从沙棘果油中提纯棕榈油酸的方法 | |
CN1324044C (zh) | 一种从女贞叶中提取熊果酸的方法 | |
CN1094291A (zh) | 鱼腥草口服液 | |
CN1297753A (zh) | 一种用作镇静安眠药品或保健品的海带制品的制备方法 | |
CN1413642A (zh) | 提取真菊药用成分的方法及提取物 | |
CN1075609A (zh) | 西瓜翠提取物的提取方法 | |
CN1051859A (zh) | 雷公藤提取物及其β-环糊精包合物的制备工艺 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: BEIJING RUIDE MEYER TECHNOLOGY DEVELOPMENT CO., L Free format text: FORMER OWNER: ZHAO AIPING Effective date: 20080516 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20080516 Address after: Beijing City, Changping District science and Technology Park white floating Springs Road No. 10, building 610611 Beikong Patentee after: Beijing Reed Technology Development Co., Ltd. Address before: No. ten, No. 89, Ji'nan, Shandong Patentee before: Zhao Aiping |
|
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Qingdao Jinfeng Pharmaceutical Co., Ltd. Assignor: Beijing Reed Technology Development Co., Ltd. Contract fulfillment period: 2009.5.6 to 2012.5.5 contract change Contract record no.: 2009110000114 Denomination of invention: Extraction and application of Lobed Kudzuvine Granted publication date: 20001208 License type: General permission Record date: 2009.5.21 |
|
LIC | Patent licence contract for exploitation submitted for record |
Free format text: COMMON LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.5.6 TO 2012.5.5; CHANGE OF CONTRACT Name of requester: QINGDAO JINFENG PHARMACEUTICAL CO., LTD. Effective date: 20090521 |
|
CX01 | Expiry of patent term |
Granted publication date: 20010131 |
|
EXPY | Termination of patent right or utility model |