CN116272369A - Tangential flow filtration system - Google Patents
Tangential flow filtration system Download PDFInfo
- Publication number
- CN116272369A CN116272369A CN202211591625.0A CN202211591625A CN116272369A CN 116272369 A CN116272369 A CN 116272369A CN 202211591625 A CN202211591625 A CN 202211591625A CN 116272369 A CN116272369 A CN 116272369A
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- Prior art keywords
- tangential flow
- circulating
- filtration system
- tank
- flow filtration
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000009295 crossflow filtration Methods 0.000 title claims abstract description 35
- 239000007788 liquid Substances 0.000 claims abstract description 70
- 239000000463 material Substances 0.000 claims abstract description 15
- 239000012530 fluid Substances 0.000 claims description 31
- 238000001802 infusion Methods 0.000 claims description 26
- 230000001502 supplementing effect Effects 0.000 claims description 12
- 230000020169 heat generation Effects 0.000 abstract description 5
- 238000010008 shearing Methods 0.000 abstract description 5
- 230000002779 inactivation Effects 0.000 abstract description 2
- 239000012528 membrane Substances 0.000 description 10
- 230000001105 regulatory effect Effects 0.000 description 9
- 238000001914 filtration Methods 0.000 description 7
- 229920002521 macromolecule Polymers 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000008569 process Effects 0.000 description 5
- 230000001276 controlling effect Effects 0.000 description 4
- 238000010992 reflux Methods 0.000 description 4
- 238000007599 discharging Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 150000003384 small molecules Chemical class 0.000 description 3
- 230000009849 deactivation Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012527 feed solution Substances 0.000 description 1
- 238000002637 fluid replacement therapy Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 238000001471 micro-filtration Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
- B01D65/10—Testing of membranes or membrane apparatus; Detecting or repairing leaks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B37/00—Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B65/00—Details peculiar to packaging machines and not otherwise provided for; Arrangements of such details
Abstract
The invention discloses a tangential flow filtration system which comprises a circulating tank, a circulating pump, a tangential flow filter and a temperature control device, wherein the circulating tank and the tangential flow filter are connected to form a circulating loop, the circulating pump is arranged on the circulating loop and used for providing power for the circulating flow of materials in the circulating loop, the circulating tank is connected with a pressurizing device, the pressurizing device is used for increasing and maintaining the pressure inside the circulating tank to provide the pressure required by the tangential flow filter, and the temperature control device is used for controlling the temperature of feed liquid in the circulating loop. The tangential flow filtration system has the advantages of reducing heat generation, avoiding material liquid inactivation caused by higher shearing force, reducing the lift of the circulating pump and the like.
Description
Technical Field
The invention relates to the technical field of food and medicine packaging mechanical equipment, in particular to a tangential flow filtration system.
Background
Tangential flow filtration (including microfiltration and ultrafiltration) is a common downstream separation technique for biopharmaceuticals, commonly found in clarification of feed streams, buffer displacement, and product concentration. As shown in fig. 1, the existing tangential flow filtration system comprises: a tangential flow filter having a set of membrane modules therein, large molecules or particles being trapped upstream by the membrane modules, small molecules passing through the membrane modules and downstream; the circulating pump is used for driving feed liquid to tangentially flow along the surface of the membrane and wash the surface of the membrane so as to reduce the membrane filtration resistance; a fluid infusion pump; a circulation tank; a set of temperature control device (a tank jacket is used for controlling the temperature, or a reflux end is arranged on an online heat exchanger); the pressure regulating valve is positioned at the reflux end and used for controlling the average transmembrane pressure difference of the filtering membrane to be used as the driving force of filtering; corresponding valves and pipelines and meters. The working process of the existing tangential flow filtration system comprises the following steps: the material liquid is pumped into the circulating tank body through the liquid supplementing pump, the material liquid enters the circulating pump through the tank bottom valve, then enters the tangential flow filter, and then returns to the tank body through the pressure regulating valve. The small molecule feed solution passes through the membrane module of the tangential flow filter and enters downstream for separation. In the working process, the circulating tank body is kept at normal pressure, the circulating pump provides tangential flow velocity, and the system adjusts the rotating speed of the circulating pump according to the set flow velocity requirement so as to achieve the set flow velocity. At the same time, the system adjusts the TMP to a set value by using a pressure regulating valve at the return end of the tangential flow filter according to the set TMP requirement.
Existing tangential flow filtration systems suffer from the following drawbacks:
1) On one hand, the pressure regulating valve can generate higher pressure drop at two ends of the pressure regulating valve, so that the heat generation is high, and the temperature rise of the feed liquid is obvious; on the other hand, the feed liquid passes through the pressure regulating valve to generate higher back pressure, the flow channel is suddenly reduced, a high-speed flow area is provided, and higher shearing force is generated, so that macromolecular products of the feed liquid are deactivated or degraded.
2) Tangential flow filtration provides tangential flow rate through the circulation pump with a small line pressure loss of tangential flow, typically less than 0.5bar g, but due to TMP requirements the circulation pump is forced to provide a higher pump outlet pressure, typically 1-3bar g, requiring a higher lift of the circulation pump.
Disclosure of Invention
The invention aims to solve the technical problems of overcoming the defects of the prior art and providing a tangential flow filtration system which can reduce heat generation, avoid the deactivation of feed liquid caused by higher shearing force and reduce the lift of a circulating pump.
In order to solve the technical problems, the invention adopts the following technical scheme:
the tangential flow filtration system comprises a circulation tank, a circulation pump, a tangential flow filter and a temperature control device, wherein the circulation tank and the tangential flow filter are connected to form a circulation loop, the circulation pump is arranged on the circulation loop and used for providing power for the circulation flow of materials in the circulation loop, the circulation tank is connected with a pressurizing device, the pressurizing device is used for increasing and maintaining the internal pressure of the circulation tank to provide the pressure required by the tangential flow filter, and the temperature control device is used for controlling the temperature of feed liquid in the circulation loop.
As a further improvement of the above technical scheme:
the pressurizing device includes a compressed air supply part and a pressurizing valve, and the compressed air supply part is connected with the circulation tank through the pressurizing valve.
And a pressurizing pipe is connected between the compressed air supply part and the circulating tank, and the pressurizing valve is arranged on the pressurizing pipe.
The temperature control device is arranged on the circulation loop.
The temperature control device is arranged on the circulating tank.
The pipeline between the liquid outlet of the circulating tank and the inlet of the tangential flow filter is provided with a first pressure gauge and a flowmeter, and the pipeline between the outlet of the tangential flow filter and the liquid return port of the circulating tank is provided with a second pressure gauge.
The tangential flow filtration system further comprises a control module, and the circulating pump, the first pressure gauge, the flowmeter and the second pressure gauge are all electrically connected with the control module.
The circulating tank is also connected with a liquid supplementing device, and the liquid supplementing device is electrically connected with a temperature control device.
The fluid infusion device comprises a fluid infusion part, a fluid infusion pipe and a fluid infusion pump, wherein the fluid infusion part is connected with the circulating tank through the fluid infusion pipe, and the fluid infusion pump is arranged on the fluid infusion pipe and is electrically connected with the control module.
The tangential flow filter is connected with a liquid draining component, a third pressure gauge is arranged on a pipeline between the liquid draining component and the tangential flow filter, and the third pressure gauge is electrically connected with the control module.
Compared with the prior art, the invention has the advantages that:
the tangential flow filtration system of the invention, working process: the pressurizing means maintains the pressure inside the circulation tank at a suitable value to provide the pressure required by the tangential flow filter; the circulating pump is started to enable materials in the circulating loop to circularly flow, namely, feed liquid enters the tangential flow filter from the bottom outlet of the circulating tank, small molecular materials are filtered by the tangential flow filter, and then the feed liquid enters the circulating tank from the tangential flow filter outlet. Compared with the existing tangential flow filtration system, the tangential flow filtration system has the advantages that firstly, a circulating tank and a pressure regulating valve at the reflux end of the tangential flow filter are omitted, heat generation is reduced, and the material liquid inactivation caused by high shearing force can be avoided; secondly, the lift of the circulating pump is reduced.
Drawings
FIG. 1 is a schematic diagram of a prior tangential flow filtration system.
FIG. 2 is a schematic diagram of the tangential flow filtration system of the present invention.
The reference numerals in the drawings denote:
1. a circulation tank; 11. a fluid supplementing device; 111. a fluid replacement component; 112. a fluid supplementing pipe; 113. a fluid supplementing pump; 2. a circulation pump; 3. tangential flow filters; 31. a liquid discharging part; 32. a third pressure gauge; 33. a membrane module; 34. a macromolecule feed liquid backflow space; 35. filtering out the small molecule feed liquid; 36. a liquid outlet pipe; 37. a circulation pipe; 4. a temperature control device; 5. a pressurizing device; 51. a compressed air supply part; 52. a pressurization valve; 53. a pressurizing tube; 54. an air filter; 6. a first pressure gauge; 7. a flow meter; 8. a second pressure gauge; 9. and a control module.
Detailed Description
The invention will be described in further detail with reference to the drawings and the specific examples.
As used in this disclosure and in the claims, the terms "a," "an," "the," and/or "the" are not specific to a singular, but may include a plurality, unless the context clearly dictates otherwise. The terms "first," "second," and the like, as used in this disclosure, do not denote any order, quantity, or importance, but rather are used to distinguish one element from another. Likewise, the word "comprising" or "comprises", and the like, means that elements or items preceding the word are included in the element or item listed after the word and equivalents thereof, but does not exclude other elements or items. The terms "connected" or "connected," and the like, are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect.
Fig. 2 shows an embodiment of the tangential flow filtration system of the present invention, which comprises a circulation tank 1, a circulation pump 2, a tangential flow filter 3 and a temperature control device 4, wherein the circulation tank and the tangential flow filter 3 are connected to form a circulation loop, the circulation pump 2 is arranged on the circulation loop to power the circulation flow of the material in the circulation loop, the circulation tank 1 is connected with a pressurizing device 5, the pressurizing device 5 increases and maintains the pressure inside the circulation tank 1 to provide the pressure required by the tangential flow filter 3, and the temperature control device 4 is used for controlling the temperature of the material liquid in the circulation loop.
The tangential flow filtration system works as follows: the pressurizing means 5 keeps the internal pressure of the circulation tank 1 at a suitable value to provide the pressure required by the tangential flow filter 3; the circulating pump 2 is started to enable materials in the circulating loop to circulate, namely, feed liquid enters the tangential flow filter 3 from the bottom outlet of the circulating tank 1, small molecular materials are filtered out by the tangential flow filter 3, and then the feed liquid enters the circulating tank 1 from the outlet of the tangential flow filter 3. Compared with the existing tangential flow filtration system, the tangential flow filtration system has the advantages that firstly, the pressure regulating valves at the reflux ends of the circulating tank 1 and the tangential flow filter 3 are omitted, heat generation is reduced, and the material liquid deactivation caused by higher shearing force can be avoided; secondly, the lift of the circulating pump 2 is reduced.
Specifically, the bottom of the circulation tank 1 is provided with a liquid outlet, the side part is provided with a liquid return port, a membrane component 33 is arranged in the tangential flow filter 3, the membrane component 33 divides the interior of the tangential flow filter 3 into a macromolecule liquid return space 34 and a micromolecule liquid filtering space 35, the macromolecule liquid return space 34 is provided with an inlet and an outlet, the liquid outlet of the circulation tank 1 is connected with the inlet of the macromolecule liquid return space 34 through a liquid outlet pipe 36, and the outlet of the macromolecule liquid return space 34 is connected with the liquid return port of the circulation tank 1 through a circulation pipe 37. The temperature control device 4 is arranged on the circulation circuit, in particular on the circulation pipe 37. The circulation pump 2 is arranged on the outlet pipe 36 or the circulation pipe 37, in this embodiment the circulation pump 2 is arranged on the outlet pipe 36. Of course, in other embodiments, the temperature control device 4 may be disposed on the circulation tank 1, equivalent to tank jacket temperature control.
In the present embodiment, the pressurizing device 5 includes a compressed air supply member 51 and a pressurizing valve 52, and the compressed air supply member 51 is connected to the circulation tank 1 through the pressurizing valve 52. By opening the pressurization valve 52 and activating the compressed air supply means 51, the pressure in the circulation tank 1 can be raised and maintained. Specifically, a pressurizing pipe 53 is connected between the compressed air supply member 51 and the circulation tank 1, and a pressurizing valve 52 is provided on the pressurizing pipe 53.
In this embodiment, the pressurizing pipe 53 is connected to the top of the circulation tank 1. The pressurizing pipe 53 is further provided with an air filter 54 to clean the pressurized air entering the circulation tank 1.
In this embodiment, a first pressure gauge 6 and a flow meter 7 are disposed on a pipeline between the liquid outlet of the circulation tank 1 and the inlet of the tangential flow filter 3, and a second pressure gauge 8 is disposed on a pipeline between the outlet of the tangential flow filter 3 and the liquid return port of the circulation tank 1. The first pressure gauge 6 is used for measuring the pressure value in the pipeline between the liquid outlet of the circulation tank 1 and the inlet of the tangential flow filter 3, i.e. measuring the pressure value in the liquid outlet pipe 36, and the flow meter 7 is used for measuring the flow rate of the liquid in the pipeline between the liquid outlet of the circulation tank 1 and the inlet of the tangential flow filter 3, i.e. measuring the flow rate of the liquid in the liquid outlet pipe 36. The second pressure gauge 8 is used to measure the pressure value in the pipe between the outlet of the tangential flow filter 3 and the return port of the circulation tank 1, i.e. in the circulation pipe 37.
In this embodiment, the tangential flow filtration system further comprises a control module 9, and the circulation pump 2, the first pressure gauge 6, the flow meter 7 and the second pressure gauge 8 are all electrically connected to the control module 9. The control module 9 can adjust the power of the pressurizing device 5 according to the pressure values measured by the first pressure gauge 6 and the second pressure gauge 8, so that the pressure value in the circulation loop is in a proper range to maintain the filtering effect of the tangential flow filter 3. The control module 9 can adjust the power of the circulation pump 2 according to the flow value measured by the flow meter 7 so that the flow in the circulation loop is in a proper range.
In this embodiment, the circulation tank 1 is further connected with a fluid-supplementing device 11, and the fluid-supplementing device 11 is electrically connected with the control module 9. The fluid replenishing device 11 is used for replenishing the circulating tank 1 with fluid. A liquid level sensor can be arranged in the circulating tank 1 and is electrically connected with the control module 9. When the liquid level sensor detects that the liquid level is at a low level, the control module 9 enables the liquid supplementing device 11 to be started, liquid is supplemented to the circulating tank 1, and when the liquid level is at a high level, the control module 9 enables the liquid supplementing device 11 to be stopped.
In this embodiment, the fluid infusion device 11 includes a fluid infusion part 111, a fluid infusion tube 112, and a fluid infusion pump 113, the fluid infusion part 111 is connected to the circulation tank 1 through the fluid infusion tube 112, and the fluid infusion pump 113 is disposed on the fluid infusion tube 112 and electrically connected to the control module 9. When the liquid level sensor detects that the liquid level is at a low level, the control module 9 enables the liquid supplementing pump 113 to be started, and supplements the circulating tank 1 with liquid, and when the liquid level is at a high level, the control module 9 enables the liquid supplementing pump 113 to be stopped.
In this embodiment, the tangential flow filter 3 is connected with a drain member 31, and a third pressure gauge 32 is disposed on a pipe between the drain member 31 and the tangential flow filter 3, and the third pressure gauge 32 is electrically connected with the control module 9. Specifically, the liquid discharging member 31 is connected to the small molecular weight feed liquid filtering space 35 of the tangential flow filter 3 for discharging the feed liquid in the small molecular weight feed liquid filtering space 35.
The bottom of the circulating tank 1 is provided with a bottom valve, and is connected with a circulating pump 2 through the bottom valve.
The tangential flow filtration system of the present invention comprises the following process steps:
1. the circulation tank 1 is kept at normal pressure at the beginning, and a valve at the bottom of the circulation tank 1 is opened to enable the circulation tank 1, the circulation pump 2 and the tangential flow filter 3 to form an open loop;
2. starting the circulating pump 2 to provide tangential flow velocity, and adjusting the rotating speed of the circulating pump 2 according to the set flow velocity requirement to reach the set flow velocity and reach a steady state;
3. the pressurization valve 52 is opened to form an open flow path.
4. Compressed air is introduced into the circulating tank 1, and the pressure in the circulating tank 1 is regulated by a pressurizing valve 52 according to the set transmembrane pressure difference set value (TMP) and the actual transmembrane pressure difference value (TMP, 6,8, 32 are calculated) for comparison, so that the TMP reaches the set value;
5. fresh buffer solution is replenished into the circulating tank 1 through the replenishing device 11, the replenishing flow rate is controlled by the weight of the circulating tank 1 (optional), and dialysis is performed until the process end point is reached after the stable state is reached; or concentrating until reaching the process end point after reaching the stable state;
6. stopping fluid infusion, depressurizing the circulating tank 1, and recovering to normal pressure;
7. stopping the circulation pump 2;
8. and (5) recycling the product.
While the invention has been described in terms of preferred embodiments, it is not intended to be limiting. Many possible variations and modifications of the disclosed technology can be made by anyone skilled in the art, or equivalent embodiments with equivalent variations can be made, without departing from the scope of the invention. Therefore, any simple modification, equivalent variation and modification of the above embodiments according to the technical substance of the present invention shall fall within the scope of the technical solution of the present invention.
Claims (10)
1. Tangential flow filtration system, including circulation tank (1), circulating pump (2), tangential flow filter (3) and temperature control device (4), its characterized in that: the circulating tank (1) is connected with the tangential flow filter (3) to form a circulating loop, the circulating pump (2) is arranged on the circulating loop and is used for providing power for circulating flow of materials in the circulating loop, the circulating tank (1) is connected with a pressurizing device (5), the pressurizing device (5) is used for increasing and maintaining the internal pressure of the circulating tank (1) to provide the pressure required by the tangential flow filter (3), and the temperature control device (4) is used for controlling the temperature of the material liquid in the circulating loop.
2. The tangential flow filtration system of claim 1, wherein: the pressurizing device (5) comprises a compressed air supply part (51) and a pressurizing valve (52), wherein the compressed air supply part (51) is connected with the circulating tank (1) through the pressurizing valve (52).
3. The tangential flow filtration system of claim 2, wherein: a pressurizing pipe (53) is connected between the compressed air supply part (51) and the circulating tank (1), and the pressurizing valve (52) is arranged on the pressurizing pipe (53).
4. A tangential flow filtration system as defined in claim 3, wherein: the temperature control device (4) is arranged on the circulation loop.
5. A tangential flow filtration system as defined in claim 3, wherein: the temperature control device (4) is arranged on the circulating tank (1).
6. The tangential flow filtration system of any of claims 1-5, wherein: the device is characterized in that a first pressure gauge (6) and a flowmeter (7) are arranged on a pipeline between a liquid outlet of the circulation tank (1) and an inlet of the tangential flow filter (3), and a second pressure gauge (8) is arranged on a pipeline between an outlet of the tangential flow filter (3) and a liquid return port of the circulation tank (1).
7. The tangential flow filtration system of claim 6, wherein: the tangential flow filtration system further comprises a control module (9), and the circulating pump (2), the first pressure gauge (6), the flowmeter (7) and the second pressure gauge (8) are all electrically connected with the control module (9).
8. The tangential flow filtration system of claim 7, wherein: the circulating tank (1) is also connected with a liquid supplementing device (11), and the liquid supplementing device (11) is electrically connected with the temperature control device (4).
9. The tangential flow filtration system of claim 8, wherein: the fluid infusion device (11) comprises a fluid infusion part (111), a fluid infusion pipe (112) and a fluid infusion pump (113), wherein the fluid infusion part (111) is connected with the circulating tank (1) through the fluid infusion pipe (112), and the fluid infusion pump (113) is arranged on the fluid infusion pipe (112) and is electrically connected with the control module (9).
10. The tangential flow filtration system of claim 7, wherein: the tangential flow filter (3) is connected with a liquid draining component (31), a third pressure gauge (32) is arranged on a pipeline between the liquid draining component (31) and the tangential flow filter (3), and the third pressure gauge (32) is electrically connected with the control module (9).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211591625.0A CN116272369A (en) | 2022-12-12 | 2022-12-12 | Tangential flow filtration system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211591625.0A CN116272369A (en) | 2022-12-12 | 2022-12-12 | Tangential flow filtration system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116272369A true CN116272369A (en) | 2023-06-23 |
Family
ID=86829359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211591625.0A Pending CN116272369A (en) | 2022-12-12 | 2022-12-12 | Tangential flow filtration system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116272369A (en) |
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2022
- 2022-12-12 CN CN202211591625.0A patent/CN116272369A/en active Pending
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