CN116251143A - Pharmaceutical composition for accelerating wound healing and removing scars and application thereof - Google Patents
Pharmaceutical composition for accelerating wound healing and removing scars and application thereof Download PDFInfo
- Publication number
- CN116251143A CN116251143A CN202111498234.XA CN202111498234A CN116251143A CN 116251143 A CN116251143 A CN 116251143A CN 202111498234 A CN202111498234 A CN 202111498234A CN 116251143 A CN116251143 A CN 116251143A
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- Prior art keywords
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- wound healing
- pharmaceutical composition
- accelerating wound
- scars
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a group of traditional Chinese medicines, in particular to a medicine composition for accelerating healing of burns and scalds wound surfaces and application thereof. A pharmaceutical composition for accelerating wound healing and removing scars, comprising an extract of the following components: radix Arnebiae, coptidis rhizoma, scutellariae radix, cortex Phellodendri, mume fructus, catechu, borneolum Syntheticum, and Cera flava. A method for preparing a pharmaceutical composition for accelerating wound healing and removing scars, comprising the following steps: a) Preparation of lithospermum extract: b) Decocting Coptidis rhizoma, scutellariae radix and cortex Phellodendri in molten Cera flava respectively to obtain three pastes, which are Coptidis rhizoma paste, scutellariae radix paste and cortex Phellodendri paste. c) Extracting mume fructus and Catechu with ethanol, filtering to obtain medicinal liquid, decocting the medicines prepared in steps a, b and c together, concentrating under reduced pressure to obtain soft extract, continuously stirring during decoction, removing fire, adding Borneolum Syntheticum 10 parts with slow fire, decocting for 15-30 min, and naturally cooling to obtain burn and scald ointment. The invention aims to provide a pharmaceutical composition for accelerating wound healing and removing scars, and a traditional Chinese medicine external medicine which is fast in wound healing and difficult to leave scars.
Description
Technical Field
The invention relates to a group of traditional Chinese medicines, in particular to a medicine composition for accelerating healing of burns and scalds wound surfaces and application thereof.
Background
Burn and scald is a common injury in daily life and production labor, the pain of patients is obvious, the wound surface is easy to be infected and healed for a long time, the common conventional treatment is poor in curative effect, and scars are easy to be left. The severity of the burn and scald is mainly judged according to the position and the area size of the burn and scald and the depth of the burn and scald. Burns and scalds are serious in the head and face parts or not in the head and face parts, but the burns and scalds are large in area and deep in depth and are generally divided into three degrees according to the depth: 1. burn and scald at one time: the epidermis is only injured, the injured skin is reddish, swollen and hot and spicy and painful, but no blisters appear. 2. Second degree burn and scald: injury to dermis, local redness and swelling, fever, and pain, and obvious blisters. 3. Three-degree burn and scald: the whole skin, including the underlying fat, bones and muscles, is damaged, the skin is darkened and necrotic, and instead the pain is not intense, as many nerves are damaged together. The disease is long, the disease is repeatedly caused, the disease is relatively intractable, and the physical and mental health, life and work of patients are seriously affected. At present, various medicines for treating burns and scalds are mainly divided into paste, liquid, foam and the like. Such as: the antibacterial spray mainly comprises "Beijing Wan hong" and "wet burn ointment", and is mainly used for activating blood and detoxicating, detumescence and relieving pain, removing necrotic tissue and promoting granulation, and is used for mild water, fire scald and wound surface fester. However, the above drugs have the following disadvantages: jingwanhong is used for treating second degree burns and scalds, has a slow curative effect and can heal only after about 25 days of clinical test; and the improper use can cause a plurality of side effects, such as easy suppuration infection and difficult healing of wounds, and easy scar leaving, and the medicinal powder has various defects of difficult debridement. In particular to an external preparation which can accelerate the wound healing and is not easy to leave scars.
Disclosure of Invention
The invention aims to provide a pharmaceutical composition for accelerating wound healing and removing scars, and a traditional Chinese medicine external medicine which is fast in wound healing and difficult to leave scars. A pharmaceutical composition for accelerating wound healing and removing scars, comprising an extract of the following components: radix Arnebiae, coptidis rhizoma, scutellariae radix, cortex Phellodendri, mume fructus, catechu, borneolum Syntheticum, and Cera flava.
Further, each part of the medicine composition for accelerating the healing of the burn and scald wound comprises the following raw materials in parts by weight: 40-50 parts of lithospermum, 20-30 parts of coptis chinensis, 20-30 parts of radix scutellariae, 20-30 parts of cortex phellodendri, 20-30 parts of dark plum fruit, 10-20 parts of catechu, 10-20 parts of borneol and 30-40 parts of beeswax.
Further, the paint comprises the following components in parts by weight: 50 parts of lithospermum, 20 parts of coptis chinensis, 20 parts of radix scutellariae, 20 parts of cortex phellodendri, 30 parts of dark plum fruit, 20 parts of catechu, 10 parts of borneol and 30-40 parts of beeswax.
Further, the invention also provides a pharmaceutical composition for accelerating wound healing and removing scars, which comprises the following steps:
a) Preparation of lithospermum extract:
weighing 50 parts of lithospermum, cleaning, removing impurities, drying, crushing, and sieving with a 100-mesh sieve to obtain the Chinese herbal medicine crushed material.
Soaking radix Arnebiae crushed material in sesame oil for more than 1 hr, heating in water bath at 45-60deg.C for 30min-1 hr, and has good fractionation effect to prevent water vapor from entering radix Arnebiae extract. Decocting radix Arnebiae extract at 45-60deg.C for 30-45 min, and centrifuging to obtain radix Arnebiae oil.
The added traditional Chinese medicine natural indigo 10 parts has cold property and salty taste, and can clear away heat and toxic materials, cool blood and remove spots, purge fire and calm convulsion and stop bleeding. Its advantages are high effect on treating wound, and long service life.
b) Respectively decocting 20 parts of coptis chinensis, 20 parts of radix scutellariae and 20 parts of cortex phellodendri in melted beeswax for 30min to obtain three pastes which are respectively coptis chinensis paste, radix scutellariae paste and cortex phellodendri paste for standby.
c) Extracting mume fructus 30 parts and Catechu 20 parts with 75% ethanol of 12BV for 1.5 hr, filtering to obtain medicinal liquid, and extracting the residue with 75% ethanol for 1 hr.
Filtering to obtain medicinal liquid, mixing the two medicinal liquids, recovering ethanol under reduced pressure, and concentrating the medicinal liquid.
d) Placing the medicines prepared in a, b and c together, decocting, concentrating under reduced pressure to obtain soft extract, and heating the extract in water bath at 70-90deg.C for 30-45 min while avoiding water vapor. Continuously stirring during the decocting process, then removing fire, adding 10 parts of borneol, slowly decocting for 15-30 minutes with small fire, and naturally cooling to obtain the burn and scald ointment.
Further, pearl powder can be added in the preparation process of the pharmaceutical composition for accelerating wound healing and removing scars.
Furthermore, 10 parts of schizonepeta spike and 10 parts of stir-fried burdock are added in the preparation process of the medicine composition for accelerating wound healing and removing scars so as to permeate toxin and regulate yin and yang.
The invention has scientific formula and reasonable compatibility, and the components are synergistic in synergy, has the effects of promoting granulation, removing putrefaction, relieving pain and itching, clearing heat and detoxicating, and having no toxic or side effect, can improve the regeneration capability of the skin tissue at the wound, promote the rapid growth of new skin and is not easy to leave scars. In the formula, lithospermum is taken as a monarch drug, the lithospermum is taken as a monarch drug for clearing heat and detoxicating, activating blood and removing stasis, and desmodium, baical skullcap root, coptis chinensis and amur corktree bark are taken as ministerial drugs, so that the effects of clearing heat and drying dampness, cooling blood and detoxicating, diminishing inflammation and relieving pain, inhibiting bacterial growth, promoting cell growth and repairing are achieved, and scalding is better relieved and skin is repaired; the combined spicebush root and the catechu borneol are used as adjuvant drugs, and play roles in promoting blood circulation, detumescence, promoting tissue regeneration and pain, relieving exterior and interior, clearing heat and relieving pain and promoting tissue regeneration, promoting blood circulation and removing obstruction in channels, and promoting skin repair in the treatment.
Detailed Description
The technical scheme of the invention is further explained below by combining specific embodiments.
Example 1:
the invention aims to provide a pharmaceutical composition for accelerating wound healing and removing scars, and a traditional Chinese medicine external medicine which is fast in wound healing and difficult to leave scars. A pharmaceutical composition for accelerating wound healing and removing scars, comprising an extract of the following components: 50 parts of lithospermum, 10 parts of natural indigo, 20 parts of coptis chinensis, 20 parts of radix scutellariae, 20 parts of amur corktree bark, 30 parts of dark plum fruit, 20 parts of catechu, 10 parts of borneol and 30-40 parts of beewax.
a) Preparation of lithospermum extract:
weighing 50 parts of lithospermum, cleaning, removing impurities, drying, crushing, and sieving with a 100-mesh sieve to obtain the Chinese herbal medicine crushed material.
Soaking radix Arnebiae crushed material in sesame oil for more than 1 hr, heating in water bath at 45-60deg.C for 30min-1 hr, and has good fractionation effect to prevent water vapor from entering radix Arnebiae extract. Decocting radix Arnebiae extract at 45-60deg.C for 30-45 min, and centrifuging to obtain radix Arnebiae oil.
The added traditional Chinese medicine natural indigo 10 parts has cold property and salty taste, and can clear away heat and toxic materials, cool blood and remove spots, purge fire and calm convulsion and stop bleeding. Its advantages are high effect on treating wound, and long service life.
b) Respectively decocting 20 parts of coptis chinensis, 20 parts of radix scutellariae and 20 parts of cortex phellodendri in melted beeswax for 30min to obtain three pastes which are respectively coptis chinensis paste, radix scutellariae paste and cortex phellodendri paste for standby.
c) Extracting mume fructus 30 parts and Catechu 20 parts with 75% ethanol of 12BV for 1.5 hr, filtering to obtain medicinal liquid, and extracting the residue with 75% ethanol for 1 hr.
Filtering to obtain medicinal liquid, mixing the two medicinal liquids, recovering ethanol under reduced pressure, and concentrating the medicinal liquid.
And (3) placing the medicines prepared in the steps a, b and c together, decocting, decompressing and concentrating to thick paste, heating and decocting the extract in a water bath at a proper temperature of 70-90 ℃ for 30-45 minutes, continuously stirring in the decoction process, then removing fire, adding 10 parts of borneol, decocting slowly with small fire for 15-30 minutes, and naturally cooling to obtain the burn and scald ointment.
Example 2:
a pharmaceutical composition for accelerating wound healing and removing scars, comprising an extract of the following components: 50 parts of lithospermum, 20 parts of coptis chinensis, 20 parts of radix scutellariae, 20 parts of cortex phellodendri, 10 parts of indigo naturalis, 30 parts of dark plum fruit, 20 parts of catechu, 10 parts of borneol and 30-40 parts of beeswax.
The invention also provides a pharmaceutical composition for accelerating wound healing and removing scars, which comprises the following steps:
a) Preparation of lithospermum extract:
weighing 50 parts of lithospermum, cleaning, removing impurities, drying, crushing, and sieving with a 100-mesh sieve to obtain the Chinese herbal medicine crushed material.
Soaking radix Arnebiae crushed material in sesame oil for more than 1 hr, heating in water bath at 45-60deg.C for 30min-1 hr, and has good fractionation effect to prevent water vapor from entering radix Arnebiae extract. Decocting radix Arnebiae extract at 45-60deg.C for 30-45 min, and centrifuging to obtain radix Arnebiae oil.
The added traditional Chinese medicine natural indigo 10 parts has cold property and salty taste, and can clear away heat and toxic materials, cool blood and remove spots, purge fire and calm convulsion and stop bleeding. Its advantages are high effect on treating wound, and long service life.
b) Respectively decocting 20 parts of coptis chinensis, 20 parts of radix scutellariae and 20 parts of cortex phellodendri in melted beeswax for 30min to obtain three pastes which are respectively coptis chinensis paste, radix scutellariae paste and cortex phellodendri paste for standby.
c) Extracting mume fructus 30 parts and Catechu 20 parts with 12BV75% ethanol for 1.5 hr, filtering to obtain medicinal liquid, and extracting residues with 75% ethanol for 1 hr
Filtering to obtain medicinal liquid, mixing the two medicinal liquids, recovering ethanol under reduced pressure, and concentrating the medicinal liquid.
And (3) placing the medicines prepared in the steps a, b and c together, decocting, decompressing and concentrating to thick paste, heating and decocting the extract in a water bath at a proper temperature of 70-90 ℃ for 30-45 minutes, continuously stirring in the decoction process, then removing fire, adding 10 parts of borneol, decocting slowly with small fire for 15-30 minutes, and naturally cooling to obtain the burn and scald ointment.
Pearl powder can be added in the preparation process of the pharmaceutical composition for accelerating wound healing and removing scars.
In the preparation process of the medicine composition for accelerating wound healing and removing scars, 10 parts of schizonepeta spike and 10 parts of stir-fried burdock can be added for toxin permeation and yin and yang leveling.
The technical scheme of the invention is used for clinic and achieves better treatment effect:
case 1: liu Mou female, 35 years old, hot oil of left hand burns for two hours. Before administration, the skin at the scalded part is red and swollen, and three peanut-sized blisters are formed. After the wound surface is disinfected, the blister is broken, the exudates are discharged, the skin is reserved, the three pastes of the invention are applied on the surface of the blister, and the three pastes are Chinese medicinal compositions of coptis paste, baikal skullcap root paste and phellodendron bark paste, the pain is relieved after 10 minutes, the pain is completely relieved after 30 minutes, the burn and scald paste is immediately given to a patient, the burn and scald paste is remarkably improved for 6 days, and the burn and scald is healed after 7-10 days. The medicine is changed three times a day, and the patient is healed in three days without scars.
Case 2: jin Mou men, 63 years old, have a history of diabetes of 13 years. The burn and scald medicine is used for diabetic foot in 11 months and 10 days in 2020. Before administration, the joints of the fingers and toes of the right foot of the patient are provided with skin crumbling of 2cm x 1cm and exudation is more. After debridement and disinfection treatment, the burn and scald medicine is smeared, the wound surface is exposed, the medicine is changed three times a day, and the wound is healed after 13 days without leaving scars.
Case 3: tian Mou a man, age 6, is scalded by boiled water for two hours on the back, two degrees to two degrees deep, and the skin damage area is 4cm by 4cm. Before administration, the skin at the burn is broken, flaky large blisters are formed, and epidermis is separated. After the wound surface disinfection treatment, the exudates in the blisters are discharged, the skin is reserved, and more exudates are obtained. After debridement and disinfection treatment, the burn and scald medicine is smeared, the wound surface is exposed, the medicine is changed three times a day, and the wound is healed after 10 days without leaving scars.
Case 4: wang Mou A, 32 years old, scalded left side shank lateral part by boiled water, scalded surface of wound 5cm 3cm, there is a plurality of blisters, severe pain, apply the three paste of the invention on the surface of blister, it is Chinese medicinal composition of cream, radix Scutellariae paste, cortex Phellodendri paste to be the rhizoma Coptidis, pain lighten after 10 minutes, after 30 minutes, not painful at all, the surface of wound red swelling subsides obviously after 12 hours, give this burn and scald paste to patient immediately, 6 days are obviously improved, cure in 7-10 days.
To sum up: the invention has scientific formula and reasonable compatibility, and the components are synergistic in synergy, has the effects of promoting granulation, removing putrefaction, relieving pain and itching, clearing heat and detoxicating, and having no toxic or side effect, can improve the regeneration capability of the skin tissue at the wound, promote the rapid growth of new skin and is not easy to leave scars.
Claims (9)
1. A pharmaceutical composition for accelerating wound healing and removing scars, characterized in that: an extract comprising the following components: radix Arnebiae, coptidis rhizoma, scutellariae radix, cortex Phellodendri, mume fructus, catechu, borneolum Syntheticum, and Cera flava.
2. A pharmaceutical composition for accelerating wound healing and removing scars as claimed in claim 1, wherein: the medicine composition comprises the following raw materials in parts by weight: 40-50 parts of lithospermum, 20-30 parts of coptis chinensis, 20-30 parts of radix scutellariae, 20-30 parts of cortex phellodendri, 20-30 parts of dark plum fruit, 10-20 parts of catechu, 10-20 parts of borneol and 30-40 parts of beeswax.
3. A pharmaceutical composition for accelerating wound healing and removing scars as claimed in claim 2, wherein: comprises the following components in parts by weight: 50 parts of lithospermum, 20 parts of coptis chinensis, 20 parts of radix scutellariae, 20 parts of cortex phellodendri, 30 parts of dark plum fruit, 20 parts of catechu, 10 parts of borneol and 30-40 parts of beeswax.
4. A pharmaceutical composition for accelerating wound healing and removing scars as claimed in claim 3, wherein: also comprises 10 parts of natural indigo.
5. A pharmaceutical composition for accelerating wound healing and removing scars as claimed in claim 3, wherein: further comprises: 10 parts of schizonepeta spike and 10 parts of fried burdock fruit.
6. A method for preparing a pharmaceutical composition for accelerating wound healing and removing scars, comprising the following steps:
a) Preparation of lithospermum extract:
weighing radix Arnebiae, cleaning, removing impurities, drying, pulverizing, and sieving with 100 mesh sieve to obtain pulverized material of radix Arnebiae. Soaking pulverized radix Arnebiae in sesame oil for more than 1 hr, heating in water bath at 45-60deg.C for 30min-1 hr while preventing water vapor from entering radix Arnebiae extract, decocting radix Arnebiae extract at 45-60deg.C for 30-45 min, and centrifuging to obtain radix Arnebiae oil.
b) Decocting Coptidis rhizoma, scutellariae radix and cortex Phellodendri in molten Cera flava for 30min to obtain three pastes respectively, which are Coptidis rhizoma paste, scutellariae radix paste and cortex Phellodendri paste.
c) Extracting mume fructus and Catechu with ethanol for 1.5 hr, filtering to obtain medicinal liquid, extracting the residue with ethanol for 1 hr, filtering to obtain medicinal liquid, mixing the medicinal liquids, recovering ethanol under reduced pressure, and concentrating the medicinal liquid.
And (3) placing the medicines prepared in the steps a, b and c together, decocting, decompressing and concentrating to thick paste, decocting the extract at a proper temperature of 70-90 ℃ for 30-45 minutes, continuously stirring in the decoction process, then removing fire, adding 10 parts of borneol, slowly decocting for 15-30 minutes with small fire, and naturally cooling to obtain the burn and scald ointment.
7. A method of preparing a pharmaceutical composition for accelerating wound healing and removing scars according to claim 6, wherein: pearl powder can be added in the preparation process of the pharmaceutical composition for accelerating wound healing and removing scars.
8. A method of preparing a pharmaceutical composition for accelerating wound healing and removing scars according to claim 6, wherein: in the preparation process of the medicine composition for accelerating wound healing and removing scars, 10 parts of schizonepeta spike and 10 parts of stir-fried burdock can be added for toxin permeation and yin and yang leveling.
9. The use of a pharmaceutical composition for accelerating wound healing and removing scars as claimed in claim 6, wherein: can be used for repairing diabetic foot skin injury.
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