CN116236549A - Antibacterial gel for females and preparation process - Google Patents
Antibacterial gel for females and preparation process Download PDFInfo
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- CN116236549A CN116236549A CN202310002112.XA CN202310002112A CN116236549A CN 116236549 A CN116236549 A CN 116236549A CN 202310002112 A CN202310002112 A CN 202310002112A CN 116236549 A CN116236549 A CN 116236549A
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Abstract
The invention discloses antibacterial gel for females and a preparation process thereof, and relates to the technical field of antibacterial gel; in order to enhance the therapeutic effect; the antibacterial gel comprises the following traditional Chinese medicine raw materials: radix Sophorae Flavescentis, coptidis rhizoma, fructus Cnidii, bombyx Batryticatus, propolis, radix Angelicae sinensis, herba Leonuri, rubi fructus, cortex Phellodendri, herba Saussureae Involueratae, kochiae fructus, fructus Gleditsiae Abnormalis, cortex moutan, radix Pulsatillae, radix Stemonae, rhizoma anemarrhenae, cortex Dictamni Radicis, long Dancao, flos Chrysanthemi Indici, myrrha, carthami flos, flos persicae, semen Impatientis, and herba Rosmarini officinalis; the process comprises the following steps: mixing the traditional Chinese medicine raw materials; cleaning; decocting with purified water; filtering to extract liquid medicine; sterilizing; adding preservative according to a certain proportion; preparing solution of sodium carboxymethylcellulose with purified water as matrix, and soaking uniformly. The antibacterial gel not only plays a role in antibacterial, but also has good treatment effect on various colpitis symptoms such as female common gynecological diseases, pruritus vulvae, leucorrhea, peculiar smell and the like.
Description
Technical Field
The invention relates to the technical field of antibacterial gel, in particular to antibacterial gel for females and a preparation process thereof.
Background
Part of people suffer from the defects of living habit, living environment and lack of health care on bodies, so that some female diseases are entangled, and the diseases are not cured for a long time, so that great inconvenience is brought to normal life and work.
The gynecological antibacterial gel is used for preventing and treating gynecological inflammatory diseases, and has the effects of diminishing inflammation, sterilizing and protecting vaginal mucosa tissue.
Through retrieval, the patent with the Chinese patent application number of CN202111002350.8 discloses antibacterial gel, and relates to the technical field of traditional Chinese medicines, and the raw materials of the antibacterial gel comprise the following components: kuh-seng, honeysuckle, wild chrysanthemum, glabrous greenbrier rhizome, rhizoma polygonati, astragalus, fructus cnidii, fructus kochiae, radix stemonae, fructus forsythiae, peppermint, hedyotis, barbed skullcap herb, cortex dictamni, cordate houttuynia and cortex moutan; the preparation of the antibacterial gel comprises the following steps: (1) raw material selection; (2) decocting the medicinal materials; (3) filtering the liquid medicine; (4) detecting the liquid medicine; (5) gel preparation; (6) filling and marking; and (7) packaging and warehousing. The bacteriostasis gel in the above patent has the following disadvantages: although the Chinese medicinal composition has a certain antibacterial effect, the Chinese medicinal composition has the functions of clearing heat, eliminating dampness, dispelling wind, relieving itching and the like, and therefore, the Chinese medicinal composition has a still need to be improved.
Disclosure of Invention
The invention aims to solve the defects in the prior art, and provides antibacterial gel for females and a preparation process thereof.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
a bacteriostatic gel for women comprises the following traditional Chinese medicine raw materials: radix Sophorae Flavescentis, coptidis rhizoma, fructus Cnidii, bombyx Batryticatus, propolis, radix Angelicae sinensis, herba Leonuri, rubi fructus, cortex Phellodendri, herba Saussureae Involueratae, kochiae fructus, fructus Gleditsiae Abnormalis, cortex moutan, radix Pulsatillae, radix Stemonae, rhizoma anemarrhenae, cortex Dictamni Radicis, long Dancao, flos Chrysanthemi Indici, myrrha, carthami flos, flos persicae, semen Impatientis, and herba Rosmarini officinalis.
Preferably: the bacteriostatic gel further comprises: sodium benzoate, sodium carboxymethylcellulose, purified water.
A preparation process of antibacterial gel for females, which comprises the following steps:
s1: mixing the traditional Chinese medicine raw materials;
s2: cleaning;
s3: decocting with purified water;
s4: filtering to extract liquid medicine;
s5: sterilizing;
s6: adding preservative according to a certain proportion;
s7: preparing solution of sodium carboxymethylcellulose with purified water as matrix, and soaking uniformly;
s8: adding the base solution into the base material according to the proportion of 1:1.5 to 2.5, and then is in gel state after being evenly stirred;
s9: filling and sub-packaging to obtain the final product.
Further preferred is: in the step S6, the preservative specifically adopts sodium benzoate, and the addition amount of the preservative accounts for 2.5-3.5% of the total mass.
As a preferred embodiment of the present invention: in the step S7, the concentration of sodium carboxymethyl cellulose of the solution is controlled to be 5-7%.
Further preferred as the present invention is: in the step S3, the decocting method comprises the following steps: the first stage is carried out for 30min, and the temperature of the first stage is controlled to be 70-90 ℃; the second stage is 60min, the second stage is controlled at 100deg.C, the third stage is 30min, and the first stage is controlled at 60-80deg.C.
As still further aspects of the invention: the method comprises the following steps:
s1: mixing the traditional Chinese medicine raw materials;
s2: cleaning;
s3: decocting with purified water;
s4: filtering to extract liquid medicine;
s5: sterilizing;
s6: adding preservative according to a certain proportion;
s7: preparing solution of sodium carboxymethylcellulose with purified water as matrix, and soaking uniformly;
s8: adding the base solution into the base material according to the proportion of 1:2, after being uniformly stirred, the mixture becomes gel;
s9: filling and sub-packaging to obtain the final product.
Based on the scheme: in the step S6, the preservative specifically adopts sodium benzoate, and the addition amount of the preservative accounts for 3% of the total mass.
Preferred on the basis of the foregoing scheme: in the step S7, the concentration of sodium carboxymethyl cellulose of the solution is controlled to be 6%.
Further preferred on the basis of the foregoing scheme is: in the step S3, the decocting method comprises the following steps: the first stage is carried out for 30min, and the temperature of the first stage is controlled at 80 ℃; the second stage is 60min, the second stage is controlled at 100deg.C, the third stage is 30min, and the first stage is controlled at 70deg.C.
The beneficial effects of the invention are as follows:
1. the antibacterial gel not only plays a role in antibacterial, but also has good treatment effect on various vaginitis symptoms such as female common gynecological diseases, pruritus vulvae, leucorrhea, peculiar smell and the like.
2. By adding various traditional Chinese medicine components such as fructus cnidii, cortex dictamni and the like, the antibacterial gel has the effects of clearing heat and drying dampness, dispelling wind and relieving itching and detoxifying, and can effectively relieve discomfort of a user after being used.
Drawings
FIG. 1 is a flow chart of a process for preparing a bacteriostatic gel for females according to the present invention;
FIG. 2 is a graph showing the relationship between the preservative addition amount and the preservative effect of the invention;
FIG. 3 is a graph showing the relationship between the ratio of the stock solution to the matrix and the gel morphology.
Detailed Description
The technical scheme of the patent is further described in detail below with reference to the specific embodiments.
Example 1:
a bacteriostatic gel for women comprises the following traditional Chinese medicine raw materials: radix Sophorae Flavescentis, coptidis rhizoma, fructus Cnidii, bombyx Batryticatus, propolis, radix Angelicae sinensis, herba Leonuri, rubi fructus, cortex Phellodendri, herba Saussureae Involueratae, kochiae fructus, fructus Gleditsiae Abnormalis, cortex moutan, radix Pulsatillae, radix Stemonae, rhizoma anemarrhenae, cortex Dictamni Radicis, long Dancao, flos Chrysanthemi Indici, myrrha, carthami flos, flos persicae, semen Impatientis, and herba Rosmarini officinalis.
Furthermore, the bacteriostatic gel further comprises: sodium benzoate, sodium carboxymethylcellulose, purified water.
A preparation process of antibacterial gel for females, which comprises the following steps:
s1: mixing the traditional Chinese medicine raw materials;
s2: cleaning;
s3: decocting with purified water;
s4: filtering to extract liquid medicine;
s5: sterilizing;
s6: adding preservative according to a certain proportion;
s7: preparing solution of sodium carboxymethylcellulose with purified water as matrix, and soaking uniformly;
s8: adding the base solution into the base material according to the proportion of 1:1.5, after being uniformly stirred, the mixture becomes gel;
s9: filling and sub-packaging to obtain the final product.
In the step S6, the preservative specifically adopts sodium benzoate, and the addition amount of the preservative accounts for 2.5% of the total mass.
In the step S7, the concentration of sodium carboxymethyl cellulose of the solution is controlled to be 5%.
In the step S3, the decocting method includes: the first stage is carried out for 30min, and the temperature of the first stage is controlled at 70 ℃; the second stage is 60min, the second stage is controlled at 100deg.C, the third stage is 30min, and the first stage is controlled at 80deg.C.
Example 2:
a bacteriostatic gel for women comprises the following traditional Chinese medicine raw materials: radix Sophorae Flavescentis, coptidis rhizoma, fructus Cnidii, bombyx Batryticatus, propolis, radix Angelicae sinensis, herba Leonuri, rubi fructus, cortex Phellodendri, herba Saussureae Involueratae, kochiae fructus, fructus Gleditsiae Abnormalis, cortex moutan, radix Pulsatillae, radix Stemonae, rhizoma anemarrhenae, cortex Dictamni Radicis, long Dancao, flos Chrysanthemi Indici, myrrha, carthami flos, flos persicae, semen Impatientis, and herba Rosmarini officinalis.
Furthermore, the bacteriostatic gel further comprises: sodium benzoate, sodium carboxymethylcellulose, purified water.
A preparation process of antibacterial gel for females, which comprises the following steps:
s1: mixing the traditional Chinese medicine raw materials;
s2: cleaning;
s3: decocting with purified water;
s4: filtering to extract liquid medicine;
s5: sterilizing;
s6: adding preservative according to a certain proportion;
s7: preparing solution of sodium carboxymethylcellulose with purified water as matrix, and soaking uniformly;
s8: adding the base solution into the base material according to the proportion of 1:2.5, after being uniformly stirred, the mixture becomes gel;
s9: filling and sub-packaging to obtain the final product.
In the step S6, the preservative specifically adopts sodium benzoate, and the addition amount of the preservative accounts for 3.5% of the total mass.
In the step S7, the concentration of sodium carboxymethyl cellulose of the solution is controlled to be 7%.
In the step S3, the decocting method includes: the first stage is carried out for 30min, and the temperature of the first stage is controlled at 90 ℃; the second stage is 60min, the second stage is controlled at 100deg.C, the third stage is 30min, and the first stage is controlled at 60deg.C.
Example 3:
a bacteriostatic gel for women comprises the following traditional Chinese medicine raw materials: radix Sophorae Flavescentis, coptidis rhizoma, fructus Cnidii, bombyx Batryticatus, propolis, radix Angelicae sinensis, herba Leonuri, rubi fructus, cortex Phellodendri, herba Saussureae Involueratae, kochiae fructus, fructus Gleditsiae Abnormalis, cortex moutan, radix Pulsatillae, radix Stemonae, rhizoma anemarrhenae, cortex Dictamni Radicis, long Dancao, flos Chrysanthemi Indici, myrrha, carthami flos, flos persicae, semen Impatientis, and herba Rosmarini officinalis.
Furthermore, the bacteriostatic gel further comprises: sodium benzoate, sodium carboxymethylcellulose, purified water.
A preparation process of antibacterial gel for females, which comprises the following steps:
s1: mixing the traditional Chinese medicine raw materials;
s2: cleaning;
s3: decocting with purified water;
s4: filtering to extract liquid medicine;
s5: sterilizing;
s6: adding preservative according to a certain proportion;
s7: preparing solution of sodium carboxymethylcellulose with purified water as matrix, and soaking uniformly;
s8: adding the base solution into the base material according to the proportion of 1:2, after being uniformly stirred, the mixture becomes gel;
s9: filling and sub-packaging to obtain the final product.
In the step S6, the preservative specifically adopts sodium benzoate, and the addition amount of the preservative is 3% of the total mass.
In the step S7, the concentration of sodium carboxymethyl cellulose of the solution is controlled to be 6%.
In the step S3, the decocting method includes: the first stage is carried out for 30min, and the temperature of the first stage is controlled at 80 ℃; the second stage is 60min, the second stage is controlled at 100deg.C, the third stage is 30min, and the first stage is controlled at 70deg.C.
The antibacterial gel prepared by the preparation process can be directly injected into a focus in vagina during treatment and use, so that the treatment effect can be achieved.
The antibacterial gel prepared by the invention has good treatment effect on various colpitis symptoms such as female common gynecological diseases, pruritus vulvae, leucorrhea, peculiar smell and the like, and ensures the use experience of users.
In order to improve the product quality, the following experiments were performed on the product:
experiment one:
the rest conditions are controlled unchanged, and the addition amount of sodium benzoate is only changed, so that the obtained product is evaluated, and the following conclusion is obtained:
| preservative addition amount | 2.50％ | 2.75％ | 3.00％ | 3.25％ | 3.50％ |
| Antiseptic effect | 88.87％ | 92.96％ | 96.45％ | 96.84％ | 97.01％ |
From the above, the amount of the preservative added is proportional to the preservative effect, and when the amount of the preservative added is 3% or more of the total mass, the preservative effect is not greatly different, so that the amount of the preservative added is preferably controlled to be 3%.
Experiment II:
the other conditions are controlled unchanged, the ratio of the stock solution to the matrix is only changed, the gel form of the obtained product is evaluated (smearing effect, preservation effect and extrusion effect from the package), and the result is scored, so that the following conclusion is obtained:
| ratio of stock solution to matrix | 1：1.5 | 1：1.75 | 1：2 | 1：2.25 | 1：2.5 |
| Gel morphology scoring | 77 | 89 | 96 | 94 | 88 |
From the above, the ratio of stock solution to matrix has a clear relationship to the final gel morphology, when the ratio of stock solution to matrix is 1:2, the gel morphology is optimal, therefore, it is preferable that the ratio of stock solution to matrix should be controlled at 1:2.
the foregoing is only a preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art, who is within the scope of the present invention, should make equivalent substitutions or modifications according to the technical scheme of the present invention and the inventive concept thereof, and should be covered by the scope of the present invention.
Claims (10)
1. A bacteriostatic gel for women is characterized by comprising the following traditional Chinese medicine raw materials: radix Sophorae Flavescentis, coptidis rhizoma, fructus Cnidii, bombyx Batryticatus, propolis, radix Angelicae sinensis, herba Leonuri, rubi fructus, cortex Phellodendri, herba Saussureae Involueratae, kochiae fructus, fructus Gleditsiae Abnormalis, cortex moutan, radix Pulsatillae, radix Stemonae, rhizoma anemarrhenae, cortex Dictamni Radicis, long Dancao, flos Chrysanthemi Indici, myrrha, carthami flos, flos persicae, semen Impatientis, and herba Rosmarini officinalis.
2. A bacteriostatic gel for females according to claim 1, characterized in that it further comprises: sodium benzoate, sodium carboxymethylcellulose, purified water.
3. A process for preparing a bacteriostatic gel for females according to claim 1 or 2, characterized by the following steps:
s1: mixing the traditional Chinese medicine raw materials;
s2: cleaning;
s3: decocting with purified water;
s4: filtering to extract liquid medicine;
s5: sterilizing;
s6: adding preservative according to a certain proportion;
s7: preparing solution of sodium carboxymethylcellulose with purified water as matrix, and soaking uniformly;
s8: adding the base solution into the base material according to the proportion of 1:1.5 to 2.5, and then is in gel state after being evenly stirred;
s9: filling and sub-packaging to obtain the final product.
4. The preparation process of the antibacterial gel for women according to claim 3, wherein in the step S6, the preservative specifically adopts sodium benzoate, and the addition amount of the preservative is 2.5-3.5% of the total mass.
5. The process for preparing a bacteriostatic gel for females according to claim 4, wherein in step S7, the concentration of sodium carboxymethyl cellulose of the solution is controlled to be 5-7%.
6. The preparation process of the antibacterial gel for women according to claim 5, wherein in the step S3, the decocting method is as follows: the first stage is carried out for 30min, and the temperature of the first stage is controlled to be 70-90 ℃; the second stage is 60min, the second stage is controlled at 100deg.C, the third stage is 30min, and the first stage is controlled at 60-80deg.C.
7. A process for preparing a bacteriostatic gel for females according to claim 3, characterized by the following steps:
s1: mixing the traditional Chinese medicine raw materials;
s2: cleaning;
s3: decocting with purified water;
s4: filtering to extract liquid medicine;
s5: sterilizing;
s6: adding preservative according to a certain proportion;
s7: preparing solution of sodium carboxymethylcellulose with purified water as matrix, and soaking uniformly;
s8: adding the base solution into the base material according to the proportion of 1:2, after being uniformly stirred, the mixture becomes gel;
s9: filling and sub-packaging to obtain the final product.
8. The preparation process of the antibacterial gel for women according to claim 7, wherein in the step S6, the preservative specifically adopts sodium benzoate, and the addition amount of the preservative is 3% of the total mass.
9. The process for preparing a bacteriostatic gel for females according to claim 8, wherein in said step S7, the concentration of sodium carboxymethyl cellulose of said solution is controlled to be 6%.
10. The preparation process of the antibacterial gel for women according to claim 9, wherein in the step S3, the decocting method is as follows: the first stage is carried out for 30min, and the temperature of the first stage is controlled at 80 ℃; the second stage is 60min, the second stage is controlled at 100deg.C, the third stage is 30min, and the first stage is controlled at 70deg.C.
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