CN116223830A

CN116223830A - Sample analyzer

Info

Publication number: CN116223830A
Application number: CN202111479634.6A
Authority: CN
Inventors: 汪云; 陈宇; 程蛟; 贾腾
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2021-12-06
Filing date: 2021-12-06
Publication date: 2023-06-06

Abstract

The present disclosure relates to a sample analyzer. The sample analyzer comprises a cleaning tank, wherein the cleaning tank is provided with a cleaning chamber with an opening at one end, a part to be cleaned is inserted into the cleaning chamber through the opening for cleaning, and the cleaning tank is provided with a liquid outlet for supplying liquid into the cleaning chamber; the liquid path system comprises a liquid supply source, a pumping mechanism and a first control valve which are sequentially connected through a connecting pipeline, wherein the pumping mechanism pressurizes liquid from the liquid supply source; one end of the first control valve is connected with the pumping mechanism, and the other end of the first control valve is communicated with the liquid outlet; a first buffer piece is arranged between the first control valve and the pumping mechanism, and the first buffer piece reduces the pressure of liquid flowing to the first control valve from the pumping mechanism when the first control valve is switched to be opened; and/or a second buffer piece is arranged between the first control valve and the liquid outlet, and the second buffer piece reduces the pressure of the liquid flowing from the first control valve to the liquid outlet when the first control valve is switched to be off. Which provides a pressure-stable liquid flow to the cleaning chamber, which can improve the cleaning effect of the parts to be cleaned.

Description

Sample analyzer

Technical Field

The present disclosure relates to the technical field of medical devices, and more particularly, to a sample analyzer.

Background

When the sample needle/reagent needle or the stirring rod is cleaned by using the fountain type cleaning pool, the liquid hanging amount after cleaning is a key performance index, and the excessive liquid hanging amount can cause the problems of needle liquid throwing, poor sample adding precision, dilution of a tested sample and the like, so that the test result is influenced. The liquid outlet direction and the liquid flow rate of the cleaning liquid at the liquid outlet of the cleaning tank are important influencing factors for influencing the liquid hanging amount of the sample needle/reagent needle or the stirring rod after cleaning.

In the existing cleaning pipeline, the pressure of a cleaning liquid supply source is generally kept, the on-off of the cleaning liquid in the fountain type cleaning pool is controlled through the switch of a valve, the pressure of water in the pipeline can generate mutation in the opening and closing processes of the valve, a water hammer phenomenon is formed, the flow of liquid at the liquid outlet of the cleaning pool is caused to be severely fluctuated, and then a sample needle/reagent needle tip or the tail end of a stirring rod is formed to hang liquid, so that the cleaning effect is poor. At present, no prior art exists for controlling the liquid outlet direction and the liquid flow rate by stabilizing the pressure of the liquid at the liquid outlet of the cleaning tank, so that the hanging liquid of a sample needle/reagent needle or a stirring rod is reduced, and the cleaning effect of the cleaning tank is improved.

Disclosure of Invention

The present disclosure is provided to solve the above-mentioned problems occurring in the prior art.

The need is felt for a sample analyzer, under the condition that the structure setting of the cleaning tank is not changed, through reasonably arranging the buffer element in the liquid path system, when the control valve in the liquid path system is switched to the on or off state, the pressure of the liquid at the liquid outlet of the cleaning tank for supplying the liquid to the cleaning chamber can not be changed drastically, the influence of the water hammer phenomenon is lightened, the liquid supply of the part to be cleaned in the cleaning chamber is ensured to be under stable liquid pressure and liquid outlet direction, the problem of hanging the part to be cleaned is reduced, and the cleaning effect is improved.

According to the sample analyzer of the present disclosure, including the washing pond, the washing pond is provided with one end open-ended wash chamber, waits to wash the part and insert through the opening wash in the wash chamber, the washing pond is provided with to the liquid outlet of the indoor confession liquid of washing. The sample analyzer according to the present disclosure further comprises a liquid path system including a liquid supply source, a pumping mechanism, and a first control valve connected in sequence by a connecting line, wherein the pumping mechanism is for pressurizing liquid from the liquid supply source; one end of the first control valve is connected with the pumping mechanism, and the other end of the first control valve is communicated with the liquid outlet; and, a first buffer member is provided between the first control valve and the pumping mechanism, the first buffer member being for reducing the pressure of the liquid flowing from the pumping mechanism to the first control valve when the first control valve is switched to be open; and/or a second buffer piece is arranged between the first control valve and the liquid outlet, and the second buffer piece is used for reducing the pressure of the liquid flowing from the first control valve to the liquid outlet when the first control valve is switched to be switched off.

According to the sample analyzer of various embodiments of the present disclosure, under the condition that the structure of the cleaning tank is not changed, only the first buffer member is arranged in the liquid path system to buffer the sudden pressure change generated when the control valve is opened, and the second buffer member is arranged in the liquid path system to buffer the sudden pressure change generated when the control valve is closed, so that the influence of the water hammer phenomenon is eliminated as much as possible, the pressure and the water outlet direction of the liquid at the liquid outlet of the cleaning tank are kept stable, the liquid hanging amount of the part to be cleaned can be reduced without additional steps and waiting time, the aim of improving the cleaning effect of the cleaning tank can be achieved, the sample to be tested and the sample to be mixed to be detected next time can be prevented from being polluted by the hanging liquid, and the accuracy of the detection result of the sample analyzer and the detection efficiency of the sample analyzer are improved.

Drawings

In the drawings, which are not necessarily drawn to scale, like numerals may describe similar components in different views. The accompanying drawings illustrate various embodiments by way of example in general and not by way of limitation, and together with the description and claims serve to explain the disclosed embodiments. Wherever possible, the same reference numbers will be used throughout the drawings to refer to the same or like parts. Such embodiments are illustrative and not intended to be exhaustive or exclusive of the present apparatus or method.

Fig. 1 shows a functional block diagram of a first example of a sample analyzer according to an embodiment of the present disclosure.

Fig. 2 shows a partial structural composition diagram of a first example of a sample analyzer according to an embodiment of the present disclosure.

Fig. 3 is a schematic diagram showing a partial structure of a second example of a sample analyzer according to an embodiment of the present disclosure.

Fig. 4 is a schematic diagram showing a partial structure of a third example of a sample analyzer according to an embodiment of the present disclosure.

Detailed Description

In order to better understand the technical solutions of the present disclosure, the following detailed description of the present disclosure is provided with reference to the accompanying drawings and the specific embodiments. Embodiments of the present disclosure will be described in further detail below with reference to the drawings and specific embodiments, but not by way of limitation of the present disclosure. The order in which the steps are described herein by way of example should not be construed as limiting if there is no necessity for a relationship between each other, and it should be understood by those skilled in the art that the steps may be sequentially modified without disrupting the logic of each other so that the overall process is not realized.

Moreover, those of ordinary skill in the art will appreciate that the drawings are provided herein for illustrative purposes and that the drawings are not necessarily drawn to scale.

Unless the context clearly requires otherwise, throughout the description and the claims, the words "comprise", "comprising", and the like are to be construed in an inclusive sense as opposed to an exclusive or exhaustive sense; that is, it is the meaning of "including but not limited to".

In the description of the present disclosure, it is to be understood that the terms "first," "second," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance. Furthermore, in the description of the present disclosure, unless otherwise indicated, the meaning of "a plurality" is two or more.

The embodiments of the present disclosure provide a sample analyzer, and the structure and main operation principle of the sample analyzer will be described with reference to fig. 1 and 2.

Fig. 1 shows a functional block diagram of a first example of a sample analyzer according to an embodiment of the present disclosure. As shown in fig. 1, the sample analyzer includes at least one functional module 10, an input module 20, a display module 30, a memory 40, a processor 50, and an alarm module 60, which are described below, respectively.

Each functional module 10 is used for performing at least one function required in the sample analysis process, and the functional modules 10 cooperate together to perform the sample analysis to obtain a sample analysis result.

Fig. 2 is a partial structural composition diagram of a first example of a sample analyzer according to an embodiment of the present disclosure. The sample analyzer of fig. 2 exemplifies the functional module 10 of the sample analyzer of fig. 1. For example, the functional module 10 may include a sample block 11, a reagent block 13, a reaction mechanism 16, a mixing mechanism 15, a sample dispensing mechanism 12, a reagent dispensing mechanism 14, a measurement mechanism 17, and the like.

Wherein the sample part 11 is used for carrying a sample. In some embodiments, the sample component 11 may include a sample distribution module (SDM, sample Delivery Module) and a front end rail; in other embodiments, the sample part 11 may also be a sample tray comprising at least one sample site where a sample container, such as a sample tube, may be placed, wherein the sample container is adapted to receive a sample, and the sample tray may be arranged to be moved to a corresponding position, e.g. a position for the sample dispensing mechanism 12 to aspirate the sample, by rotating its tray structure.

The reagent component 13 is adapted to carry a reagent and comprises at least one sample site for placing a reagent container for holding the reagent. In some embodiments, the reagent component 13 may be a reagent disk, where the reagent disk is provided in a disk-shaped structure and has a plurality of positions for carrying reagent containers, and the reagent component 13 can rotate and drive the reagent containers carried by the reagent component to rotate to a specific position, for example, a position where the reagent is sucked by the reagent dispensing mechanism 14.

The reaction mechanism 16 includes at least one placement site for placing a reaction vessel and incubating a reaction solution prepared from a sample and a reagent in the reaction vessel. For example, the reaction mechanism 16 may be a reaction disk having a disk-like configuration with one or more placement sites for placement of reaction cups, the reaction disk being capable of rotating and driving the reaction cups in its placement sites for scheduling reaction cups within the reaction disk and incubating reaction fluids in the reaction cups.

The mixing mechanism 15 is used for mixing the reaction liquid to be mixed in the reaction cup. The number of mixing mechanisms 15 may be one or more. In some embodiments, the mixing mechanism 15 may include a stirring rod driving mechanism and a stirring rod, where the stirring rod driving mechanism may drive the stirring rod to move so as to mix the reaction solution to be mixed in the reaction cup. In the above case, the member to be cleaned further includes a stirring rod.

The sample dispensing mechanism 12 is used to aspirate and discharge a sample into a reaction cup to be loaded. For example, the sample dispensing mechanism 12 may comprise a first moving member (not shown) and a sample needle (not shown) provided on the first moving member, wherein the first moving member may be used to drive the sample needle for a two-dimensional or three-dimensional movement such that the sample needle moves between a sample position and a placement position to aspirate a sample carried by the sample member 11 through the sample needle at the sample position and to discharge the sample to a cuvette to be loaded at the placement position.

The reagent dispensing mechanism 14 includes a second moving member and a reagent needle provided on the second moving member. The second moving member is for driving the sample needle to move between the reagent site and the placement site to aspirate a reagent at the reagent site through the reagent needle and discharge the reagent at the placement site. The part to be cleaned comprises a sample needle and/or a reagent needle, and the opening of the cleaning pool is positioned on the moving track of the sample needle and/or the reagent needle. In some embodiments, the reagent needle may be moved in two or three dimensions spatially by a two or three dimensional drive mechanism so that the reagent needle may be moved to aspirate the reagent carried by the reagent component 13 and to move to and discharge the reagent to the cuvette to be probed.

The measurement means 17 is for measuring a reaction solution to be measured. In some embodiments, the measurement mechanism 17 may be, for example, a light measurement component, which may be used to perform light measurement on the incubated reaction solution, so as to obtain reaction data of the sample, including detecting the luminescence intensity of the reaction solution to be measured, and calculating the concentration of the component to be measured in the sample through a calibration curve. In some embodiments, the assay mechanism 17 may be separately disposed outside of the reaction mechanism 16.

The above is some illustration of the functional module 10, and the sample analyzer in the above example may also have other components and structures, such as an input module 20 for receiving user input, a display module 30 for displaying information, and the input module 20 and the display module 30 may be integrated. In some embodiments, the sample analyzer itself may incorporate a display module, and in some embodiments, the sample analyzer may also be connected to a computer device (e.g., a computer) for displaying information via a display unit (e.g., a display screen) of the computer device. The sample analyzer in this example may further have a memory 40 and a processor 50, wherein the memory 40 may store data and programs required for various operations of the sample analyzer for sample analysis, and the processor 50 may be a CPU, GPU or other chip having arithmetic capability, which may implement the operations required for various functions of the sample analyzer by executing the programs in the memory 40 and utilizing the relevant data therein. The alarm module 60 is used for sending out corresponding alarm information according to preset rules.

According to the sample analyzer of the embodiment of the disclosure, after the sample is collected by the sample needle, after the reagent is discharged by the reagent needle, and after the reaction liquid is uniformly mixed by the stirring rod, the sample is required to enter the cleaning tank to be cleaned under the driving of the corresponding moving part/driving mechanism so as to wash away residual sample, reagent or reaction liquid and the like, so as to be used for sampling next time, sucking the reagent, uniformly mixing the reaction liquid and the like. In addition to the outer wall of the sample needle and the reagent needle being cleaned by the cleaning liquid in the cleaning tank, it is generally necessary to inject the cleaning liquid into the sample needle and the reagent needle by a member such as a syringe to clean the inner wall thereof. Thus, in some embodiments, the functional module 10 further includes a wash basin for outer wall washing of components such as sample needles, reagent needles, stirring rods waiting to be washed in the sample analyzer, and a fluid path system for providing washing fluid to the wash basin and the syringe required for inner wall washing, etc. The details of the wash tank and the fluid circuit system described above will be described with an emphasis on FIG. 3.

Fig. 3 is a schematic diagram showing a partial structure of a second example of a sample analyzer according to an embodiment of the present disclosure. The sample analyzer 100 shown in fig. 3 comprises a washing tank 101 and a liquid path system 102, wherein the washing tank 101 is provided with a washing chamber 103 with one end opened, and a liquid outlet 104 for supplying liquid into the washing chamber 103, wherein the liquid outlet 104 is positioned at the bottom of the washing tank 101, and the opening 105 is positioned at the top of the washing tank 101. When the sample needle, the reagent needle, the stirring bar wait for the cleaning member (not shown) to be cleaned after the operations of sampling, sucking and discharging the reagent, mixing the reaction liquid, and the like, is brought above the cleaning bath 101 by the corresponding moving member or driving mechanism (not shown), and then inserted into the cleaning chamber 103 through the opening 105, and cleaned with the cleaning liquid supplied from the liquid outlet 104.

In some embodiments, the fluid circuit system 102 may include a fluid supply 108 and a pumping mechanism 109, wherein the pumping mechanism 109 is configured to pressurize fluid from the fluid supply 108, and the static pressure of the pressurized fluid may be, for example, 50 kilopascals, and the pressure of the fluid at the fluid outlet 104 required to clean the components to be cleaned may be, for example, 5 kilopascals, for example, so that a pressure regulating feature may be provided in the fluid circuit system 102 to enable the fluid to drop an initial high pressure value to a desired lower pressure value during flow through the fluid circuit system 102.

In some embodiments, the fluid circuit system 102 may further include a first control valve 110 having one end connected to the pumping mechanism 109 and another end in communication with the fluid outlet 104. As shown in fig. 3, the liquid supply source 108, the pumping mechanism 109, and the first control valve 110 may be connected in sequence through the first connection pipe 106, the second connection pipe 107, and the like. In some embodiments, the first control valve 110 may be, for example, a solenoid valve, and may be switched between an on state and an off state, where the sample needle, the reagent needle, and the stirring rod wait for the cleaning component to be cleaned, and the above components to be cleaned are in suitable positions, for example, have entered the cleaning chamber, the first control valve 110 may be switched from off to on under the unified control of a processor (not shown) of the sample analyzer 100, and the duration of the opening may be appropriately set according to the specific requirements of the components to be cleaned. It is noted that the pressure of the liquid flowing therethrough may be reduced when the first control valve 110 is opened, and by way of example only, the pressure is reduced by 15% -20% or more after the liquid passes through the first control valve 110.

It is noted that, since the opening and closing of the first control valve 110 (e.g. a solenoid valve) is very rapid, e.g. even between milliseconds and hundreds of milliseconds, the pressure of the liquid at the first control valve 110 will suddenly increase or suddenly stop at the moment of opening and closing, and due to the inertia of the pressure liquid flow, a liquid flow shock wave, i.e. a water hammer, will be likely to occur, and the pressure and flow rate of the liquid will also suddenly change, which will be transmitted along the liquid path system 102 to the liquid outlet 104. In the sample analyzer 100, the first buffer 111 and/or the second buffer 112 may be further provided at one side or both sides of the first control valve 110. In some embodiments, a first buffer 111 may be provided between the first control valve 110 and the pumping mechanism 109 for reducing the pressure of the liquid flowing by the pumping mechanism 109 to the first control valve 110 when the first control valve 110 is switched to open. In other embodiments, the second buffer member 112 may be disposed between the first control valve 110 and the liquid outlet 104, for reducing the pressure of the liquid flowing from the first control valve 110 to the liquid outlet 104 when the first control valve 110 is switched off, specifically, when the first control valve 110 is switched to the off state at a relatively high speed, the forward water hammer effect will make the flow rate and the pressure of the liquid between the first control valve 110 and the liquid outlet 104 suddenly change, and the second buffer member 112 may reduce the sudden change of the flow rate and the pressure, so that the pressure of the liquid reaching the liquid outlet 104 remains relatively stable, and thus the flow rate and the liquid outlet direction of the liquid are also more stable, in particular, for the spa-type cleaning tank, the cleaning liquid may stably maintain a desired laminar flow state during the cleaning process, and bubbles are not easy to generate.

The first buffer member 111 and the second buffer member 112 may be implemented by any member having a liquid flow rate and pressure regulating effect and a combination thereof, for example, in some embodiments, the first buffer member 111 may include a first buffer pipe 111a, one end of the first buffer pipe 111a is connected to the first control valve 110, the other end of the first buffer pipe 111a is connected to the pumping mechanism 109 via the first connection pipe 106, and an elastic modulus of the first buffer pipe 111a is smaller than an elastic modulus of the first connection pipe 106.

The "elastic modulus" is a generic term describing a physical quantity of a substance or elastomer, and means that, in the elastic deformation stage, an external force is applied to the material, so that the shape of the elastomer is changed (referred to as "deformation"), and the stress and strain thereof are in a proportional relationship (i.e. conform to hooke's law), that is, the proportional coefficient obtained by dividing the stress of the elastomer in a unidirectional stress state by the strain in the direction is the "elastic modulus".

As described above, the first buffer tube 111a has a smaller elastic modulus than the first connecting tube 106, and thus when the pressure of the liquid in the tube suddenly changes, the first buffer tube 111a is deformed more greatly, so that the fluctuation of the pressure can be absorbed more greatly, and the pressure of the liquid in the end of the first buffer tube 111a, i.e., the tube at and downstream of the first control valve 110, tends to be stabilized.

In some embodiments, the inner diameter of the first buffer tube 111a is greater than the inner diameter of the first connecting tube 106, and therefore, when the outer diameters of the two are equal, the first buffer tube 111a has a correspondingly thinner tube wall. For connecting pipes of different inner diameters, a first connecting piece 113 may be connected between the first buffer pipe 111a and the first connecting pipe 106, for example, the first connecting piece 113 may comprise a pressure regulating valve having a function of regulating the pressure after the valve, i.e. by setting an adjusting mechanism in the pressure regulating valve, etc., the reducing amplitude of the liquid pressure after flowing through the pressure regulating valve is controlled, for example only, the pressure regulating valve may be set to 15% -25% of the pressure before the valve, etc., the specific amplitude and value should be set in coordination according to the setting of the respective components in the liquid path system 102, so as to ensure that the liquid pressure in the liquid path system 102 exhibits a relatively uniform multi-stage stepwise drop, instead of a broken-off drop at the individual components, such setting may reduce the impact on the pipes and components in the liquid path system 102, and may enable the cleaning liquid to reach the liquid outlet 104 at a more stable flow rate and stepwise reduced pressure. In particular, for the fountain type washing tank, the washing liquid can be stably maintained in an ideal laminar state during washing, and bubbles and the like are not easily generated.

In other embodiments, the second buffer member 112 may be disposed in the fluid path system 102, and may be disposed separately or simultaneously with the first buffer member 111. In some embodiments, the second buffer member 112 may include a second buffer tube 112a, one end of which is connected to the first control valve 110, and the other end of which is connected to the liquid outlet 104 via the second connection tube 107, and the elastic modulus of the second buffer tube 112a is smaller than that of the second connection tube 107. Therefore, when the pressure of the liquid reaching the second buffer pipe 112a is suddenly changed due to the opening or closing of the first control valve 110, the second buffer pipe 112a absorbs the fluctuation of the liquid pressure therein with a large elastic deformation, thereby making the pressure of the liquid in the end of the second buffer pipe 112a and the pipes downstream thereof more stable.

In some embodiments, the inner diameter of the second buffer tube 112a is greater than the inner diameter of the second connecting tube 107, and therefore, when the outer diameters of the two are equal, the first buffer tube 111a has a correspondingly thinner tube wall. To connect pipes of different inner diameters, a second connection 114 may be connected between the second buffer pipe 112a and the second connection pipe 107, for example the second connection 114 may comprise a reducer union comprising a first end and a second end, the inner diameter of the first end of which is smaller than the inner diameter of the second end, the second connection pipe 107 being connected to the first end of the reducer union and the second buffer pipe 112a being connected to the second end of the reducer union.

In other embodiments, the second connecting member 114 may be other components capable of connecting pipes with different inner diameters, such as the pressure regulating valve, and similarly, the first connecting member 113 for connecting the first buffer pipe 111a and the first connecting pipe 106 may also include other components capable of connecting pipes with different inner diameters, such as a reducing joint, where the reducing joint may be further provided with a buffer chamber including, but not limited to, a buffer mechanism such as a pressure spring, and the like, and is not limited thereto.

In some embodiments, the first buffer pipe 111a and the second buffer pipe 112a may be made of an elastic pipe based on PVC, and when the wall of the PVC elastic pipe is thin, it may have a small elastic modulus, and when the pressure of the liquid in the pipe changes, the PVC elastic thin-wall pipe may buffer the abrupt liquid pressure with a large elastic deformation.

Fig. 4 is a schematic diagram showing a partial structure of a third example of a sample analyzer according to an embodiment of the present disclosure. The sample analyzer 200 shown in fig. 4 has a washing tank 101 similar to the sample analyzer 100 shown in fig. 3, and includes a liquid outlet 104 at the bottom of the washing tank 101, an opening 105 at the top of the washing tank 101, and a washing chamber 103, and functions and configurations thereof are the same as those of the corresponding components of the sample analyzer 100 in fig. 3, and are not repeated herein.

The liquid path system 202 of the sample analyzer 200 may include a liquid supply source 108, a pumping mechanism 109, and a first control valve 110, which are sequentially connected through a first connection pipe 106 and a second connection pipe 107, etc., similar to the sample analyzer 100 of fig. 3, and a first buffer member 111 and a first connection member 113, etc., for connecting the first connection pipe 106 and the first buffer member 111, which may be disposed between the first control valve 110 and the pumping mechanism 109, whose functions and configurations are the same as those of the corresponding components of the sample analyzer 100 of fig. 3, and are not repeated herein.

In other embodiments, the liquid path system 202 of the sample analyzer 200 may further include a second control valve 203, a third control valve 204, a first injector 205, and a second injector 206, where one end of the first control valve 110 is connected to the pumping mechanism 109, and the other end of the first control valve may be divided into three paths, and the first path is still connected to the liquid outlet 104 through the second buffer member 112, the second connection member 114, and the second connection pipe 107 in order to supply the cleaning solution to the cleaning chamber 103; the second path may be connected to the sample needle 207 via the second control valve 203 and the first syringe 205 in sequence, for example, a cleaning liquid for cleaning the residue on the inner wall thereof may be supplied to the sample needle 207; the third path may be connected to the reagent needle 208 via the third control valve 204 and the second syringe 206 in turn, for example, a cleaning liquid for cleaning the residues of the inner wall thereof may be supplied to the reagent needle 208. Wherein the reagent needle 208 may use a different washing tank (not shown) than the washing tank 101 at the time of washing. Further, it is to be noted that, on the liquid path from the outlet end of the first control valve 110 to the first syringe 205 and the liquid path from the outlet end of the first control valve 110 to the second syringe 206, a pressure buffer member (not shown) for buffering a change in the liquid pressure in the liquid path may be provided in accordance with the cleaning requirements of the inner walls of the sample needle 207 and the reagent needle 208.

In the case of having a plurality of control valves as described above, the first control valve 110, the second control valve 203 and the third control valve 204 may be cooperatively controlled to be opened and closed under unified control of a processor (not shown) of the sample analyzer 200 according to a preset timing in accordance with the cleaning requirements of the inner wall and the outer wall of the sample needle 207, the reagent needle 208, and the stirring bar waiting cleaning member.

According to the sample analyzer disclosed by the embodiment of the disclosure, as the components for reducing the liquid pressure in the pipeline and the buffer piece for buffering and adjusting the pressure fluctuation when the liquid pressure in the pipeline suddenly changes are distributed on the path of the liquid path system, the pressure can be reduced stepwise in the flowing process of the pressurized cleaning liquid in the liquid path system, and the pressure of the liquid flowing to the liquid outlet can be ensured to be kept stable. When the inner wall and the outer wall of the sample needle, the reagent needle and the stirring rod waiting for the cleaning component are cleaned by the cleaning liquid with stable pressure, the cleaning liquid can stably maintain an ideal laminar flow state, and bubbles and the like are not easy to generate, so that the problem of hanging liquid is greatly reduced or avoided, pollution of the hanging liquid to a sample or a sample to be tested and the like detected next time is avoided, the accuracy of the detection result of the sample analyzer is improved, and the detection efficiency of the sample analyzer is improved.

Furthermore, although exemplary embodiments have been described herein, the scope thereof includes any and all embodiments having equivalent elements, modifications, omissions, combinations (e.g., of the various embodiments across schemes), adaptations or alterations based on the present disclosure. Elements in the claims are to be construed broadly based on the language employed in the claims and are not limited to examples described in the present specification or during the practice of the present application, which examples are to be construed as non-exclusive. It is intended, therefore, that the specification and examples be considered as exemplary only, with a true scope and spirit being indicated by the following claims and their full scope of equivalents.

The above description is intended to be illustrative and not restrictive. For example, the above-described examples (or one or more aspects thereof) may be used in combination with each other. For example, other embodiments may be used by those of ordinary skill in the art upon reading the above description. In addition, in the above detailed description, various features may be grouped together to streamline the disclosure. This is not to be interpreted as an intention that the disclosed features not being claimed are essential to any claim. Rather, the disclosed subject matter may include less than all of the features of a particular disclosed embodiment. Thus, the following claims are hereby incorporated into the detailed description as examples or embodiments, with each claim standing on its own as a separate embodiment, and it is contemplated that these embodiments may be combined with one another in various combinations or permutations. The scope of the invention should be determined with reference to the appended claims, along with the full scope of equivalents to which such claims are entitled.

The above embodiments are only exemplary embodiments of the present disclosure, and are not intended to limit the present invention, the scope of which is defined by the claims. Various modifications and equivalent arrangements of parts may be made by those skilled in the art, which modifications and equivalents are intended to be within the spirit and scope of the present disclosure.

Claims

1. A sample analyzer, the sample analyzer comprising:

the cleaning tank is provided with a cleaning chamber with an opening at one end, a part to be cleaned is inserted into the cleaning chamber through the opening for cleaning, and the cleaning tank is provided with a liquid outlet for supplying liquid into the cleaning chamber;

the liquid path system comprises a liquid supply source, a pumping mechanism and a first control valve which are sequentially connected through a connecting pipeline,

the pumping mechanism is for pressurizing liquid from the liquid supply;

one end of the first control valve is connected with the pumping mechanism, and the other end of the first control valve is communicated with the liquid outlet; and, in addition, the processing unit,

a first buffer is arranged between the first control valve and the pumping mechanism and is used for reducing the pressure of liquid flowing to the first control valve by the pumping mechanism when the first control valve is switched to be opened; and/or

And a second buffer piece is arranged between the first control valve and the liquid outlet and is used for reducing the pressure of liquid flowing from the first control valve to the liquid outlet when the first control valve is switched to be switched off.

2. The sample analyzer of claim 1, wherein the first buffer comprises a first buffer tube, one end of the first buffer tube is connected to the first control valve, the other end of the first buffer tube is connected to the pumping mechanism via a first connecting tube, and an elastic modulus of the first buffer tube is smaller than an elastic modulus of the first connecting tube.

3. The sample analyzer of claim 2, wherein the first buffer tube has an inner diameter greater than an inner diameter of the first connecting tube, and a first connector is connected between the first buffer tube and the first connecting tube.

4. The sample analyzer of claim 3, wherein the first connector comprises a pressure regulating valve.

5. The sample analyzer of claim 1, wherein the second buffer comprises a second buffer tube, one end of the second buffer tube is connected to the first control valve, the other end of the second buffer tube is connected to the liquid outlet via a second connecting tube, and the elastic modulus of the second buffer tube is smaller than the elastic modulus of the second connecting tube.

6. The sample analyzer of claim 5, wherein the second buffer tube has an inner diameter greater than an inner diameter of the second connecting tube, and a second connector is connected between the second buffer tube and the second connecting tube.

7. The sample analyzer of claim 6, wherein the second connector comprises a reducer union comprising a first end and a second end, the first end having an inner diameter that is smaller than an inner diameter of the second end; the second connecting pipeline is connected with the first end, and the second buffer pipeline is connected with the second end.

8. The sample analyzer of claim 2 or 5, wherein the first buffer tube and/or the second buffer tube is formed from a PVC-based elastic tube.

9. The sample analyzer of claim 1, wherein the liquid outlet is located at the bottom of the wash tank and the opening is located at the top of the wash tank.

10. The sample analyzer of claim 1, further comprising:

a sample component comprising at least one sample site for placement of a sample container for holding a sample;

a reagent component comprising at least one sample site for placement of a reagent container for holding a reagent;

the reaction mechanism comprises at least one placement position, wherein the placement position is used for placing a reaction container and incubating a reaction liquid in the reaction container, and the reaction liquid is prepared from the sample and a reagent;

the mixing mechanism is used for uniformly mixing the reaction liquid in the reaction cup;

a sample dispensing mechanism including a first moving member and a sample needle provided on the first moving member; the first moving part is used for driving the sample needle to move between the sample position and the placement position so as to suck the sample at the sample position and discharge the sample at the placement position through the sample needle;

a reagent dispensing mechanism including a second moving member and a reagent needle provided on the moving member; the second moving component is used for driving the sample needle to move between the reagent position and the placement position so as to suck reagent at the reagent position and discharge the reagent at the placement position through the reagent needle, the component to be cleaned comprises the sample needle and/or the reagent needle, and an opening of the cleaning pool is positioned on a moving track of the sample needle and/or the reagent needle;

and the measuring mechanism is used for measuring the reaction liquid to be measured.

11. The sample analyzer of claim 10, wherein the mixing mechanism comprises a stirring rod driving mechanism and a stirring rod, the stirring rod driving mechanism drives the stirring rod to move so as to mix the reaction liquid to be mixed in the reaction cup, and the part to be cleaned further comprises the stirring rod.

12. The sample analyzer of claim 10, wherein the fluid path system further comprises a second control valve, a third control valve, a first syringe and a second syringe, wherein one end of the first control valve is connected to the pumping mechanism, the other end is divided into three paths, the first path is connected to the fluid outlet, the second path is sequentially connected to the sample needle through the second control valve and the first syringe, and the third path is sequentially connected to the reagent needle through the third control valve and the second syringe.