CN116184922A - Pipetting control method, pipetting control device, computer equipment and storage medium - Google Patents

Pipetting control method, pipetting control device, computer equipment and storage medium Download PDF

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Publication number
CN116184922A
CN116184922A CN202310186977.6A CN202310186977A CN116184922A CN 116184922 A CN116184922 A CN 116184922A CN 202310186977 A CN202310186977 A CN 202310186977A CN 116184922 A CN116184922 A CN 116184922A
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China
Prior art keywords
pipetting
information
parameters
pipetting device
configuration parameters
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CN202310186977.6A
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Chinese (zh)
Inventor
吕修袁
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Suzhou HYC Technology Co Ltd
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Suzhou HYC Technology Co Ltd
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Priority to CN202310186977.6A priority Critical patent/CN116184922A/en
Publication of CN116184922A publication Critical patent/CN116184922A/en
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    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B19/00—Programme-control systems
    • G05B19/02—Programme-control systems electric
    • G05B19/04—Programme control other than numerical control, i.e. in sequence controllers or logic controllers
    • G05B19/05—Programmable logic controllers, e.g. simulating logic interconnections of signals according to ladder diagrams or function charts
    • G05B19/054—Input/output
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B2219/00—Program-control systems
    • G05B2219/10—Plc systems
    • G05B2219/11—Plc I-O input output
    • G05B2219/1103—Special, intelligent I-O processor, also plc can only access via processor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
    • Y02P90/02—Total factory control, e.g. smart factories, flexible manufacturing systems [FMS] or integrated manufacturing systems [IMS]

Abstract

The present application relates to a pipetting control method, apparatus, computer device, storage medium and computer program product. The method comprises the following steps: acquiring communication configuration information, pipetting device configuration parameters, pipetting material parameters and task execution sequence parameters; generating layout information of the pipetting equipment according to the pipetting material parameters; generating execution logic information according to the configuration parameters of the pipetting device and the pipetting device layout information; based on the communication configuration information, selecting corresponding execution logic information according to the task execution sequence parameters, sending the execution logic information to a first control end, and sending the layout information of the pipetting equipment to a second control end; the first control end is used for executing corresponding pipetting operations based on pipetting device configuration parameters and execution logic information; the second control end is used for executing corresponding layout operation based on the liquid transfer equipment layout information. By adopting the method, the pipetting can be automatically controlled.

Description

Pipetting control method, pipetting control device, computer equipment and storage medium
Technical Field
The present application relates to the field of automation control technology, and in particular, to a pipetting control method, apparatus, computer device, storage medium and computer program product.
Background
With the vigorous development of the biomedical industry, the demand of the biomedical reagent experimental automation market corresponding to the vigorous development of the biomedical industry is also becoming larger and larger.
In the related art, control and information interaction of the large-scale pipetting device is realized by using a PLC (Programmable Logic Controller ), but the use of the PLC requires a large amount of signal interaction and intervention of a third party program.
Disclosure of Invention
In view of the foregoing, it is desirable to provide a pipetting control method, apparatus, computer device, computer-readable storage medium and computer program product capable of automatically controlling pipetting.
In a first aspect, the present application provides a pipetting control method, where the method includes:
acquiring communication configuration information, pipetting device configuration parameters, pipetting material parameters and task execution sequence parameters;
generating layout information of the pipetting equipment according to the pipetting material parameters;
generating execution logic information according to the configuration parameters of the pipetting device and the pipetting device layout information;
based on the communication configuration information, sending task execution sequence parameters, pipetting device configuration parameters and logic information to a first control end, and sending the pipetting device layout information to a second control end; the first control end is used for selecting corresponding execution logic information and configuration parameters of the pipetting device according to the task execution sequence parameters to execute corresponding pipetting operations; the second control end is used for executing corresponding layout operation based on the liquid transfer equipment layout information.
In one embodiment, the generating the execution logic information according to the configuration parameters of the pipetting device and the pipetting device layout information includes:
receiving pulse information;
determining initial position information according to the pulse information;
generating target position information according to the initial position information and the pipetting device layout information;
and generating execution logic information according to the configuration parameters of the pipetting device and the target position information.
In one embodiment, after the obtaining the configuration parameters of the pipetting device, the method includes:
carrying out accuracy judgment on the configuration parameters of the pipetting device;
the performing accuracy judgment on the configuration parameters of the pipetting device includes:
when the configuration parameters of the pipetting device are within the preset parameter range, generating execution logic information according to the configuration parameters of the pipetting device, the layout information of the pipetting device and the pipetting material parameters;
and when the configuration parameters of the pipetting device are not in the preset parameter range, re-acquiring the configuration parameters of the pipetting device.
In one embodiment, the pipetting material parameters include floor data and rack data; generating the layout information of the pipetting device according to the pipetting material parameter parameters comprises the following steps:
Acquiring consumable data when the bottom plate data and the bracket data meet a first preset matching condition;
and when the consumable data and the bracket data meet a second preset matching condition, generating the layout information of the pipetting equipment.
In one embodiment, the method further comprises acquiring a status semaphore;
and generating an alarm signal according to the state signal quantity.
In one embodiment, the pipetting device configuration parameters include a pipetting configuration parameter, a pipette tip loading parameter, a pipette tip unloading parameter, a pipetting parameter and a pipetting parameter.
In a second aspect, the present application also provides a pipetting control device. The device comprises:
the acquisition module is used for acquiring communication configuration information, pipetting device configuration parameters, pipetting material parameters and task execution sequence parameters;
the layout module is used for generating layout information of the pipetting equipment according to the pipetting material parameters;
the logic module is used for generating execution logic information according to the configuration parameters of the pipetting device and the pipetting device layout information;
the control module is used for selecting corresponding execution logic information according to the task execution sequence parameters based on the communication configuration information, sending the execution logic information to the first control end, and sending the liquid transfer equipment layout information to the second control end; the first control end is used for executing corresponding pipetting operations based on pipetting device configuration parameters and execution logic information; the second control end is used for executing corresponding layout operation based on the liquid transfer equipment layout information.
In a third aspect, the present application also provides a computer device. The computer device comprises a memory storing a computer program and a processor implementing the steps of the method of any of the embodiments described above when the processor executes the computer program.
In a fourth aspect, the present application also provides a computer-readable storage medium. The computer readable storage medium having stored thereon a computer program which, when executed by a processor, implements the steps of the method of any of the embodiments described above.
In a fifth aspect, the present application also provides a computer program product. The computer program product comprising a computer program which, when executed by a processor, implements the steps of the method of any of the embodiments described above.
According to the pipetting control method, the pipetting control device, the computer equipment, the storage medium and the computer program product, the server firstly obtains the communication configuration information, the pipetting equipment configuration parameters, the pipetting material parameters and the task execution sequence parameters, then generates pipetting equipment layout information according to the pipetting material parameters, generates execution logic information according to the pipetting equipment configuration parameters and the pipetting equipment layout information, finally selects corresponding execution logic information according to the task execution sequence parameters based on the communication configuration information, and sends the execution logic information to the first control end, and sends the pipetting equipment layout information to the second control end; the first control end is used for executing corresponding pipetting operations based on pipetting device configuration parameters and execution logic information; the second control end is used for executing corresponding layout operation based on the layout information of the pipetting equipment, so that the first control end and the second control end can perform corresponding operation according to each parameter sent by the server, no intervention of a third-party program is needed, and the interaction process of the server and the terminal is simplified.
Drawings
FIG. 1 is a diagram of an application environment of a pipetting control method in one embodiment;
FIG. 2 is a flow chart of a pipetting control method in one embodiment;
FIG. 3 is a schematic diagram of the generation of placement information for a pipetting device in one embodiment;
FIG. 4 is a schematic diagram of the steps of a liquid control method in one embodiment;
FIG. 5 is a block diagram showing the construction of a pipetting control device in one embodiment;
fig. 6 is an internal structural diagram of a computer device in one embodiment.
Detailed Description
In order to make the objects, technical solutions and advantages of the present application more apparent, the present application will be further described in detail with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the present application.
The pipetting control method provided by the embodiment of the application can be applied to an application environment shown in fig. 1. Wherein the terminal 102 communicates with the server 104 via a network. The data storage system may store data that the server 104 needs to process. The data storage system may be integrated on the server 104 or may be located on a cloud or other network server. Firstly, a server acquires communication configuration information, a pipetting device configuration parameter, a pipetting material parameter and a task execution sequence parameter; then, generating layout information of the pipetting equipment according to the pipetting material parameters; generating execution logic information according to the configuration parameters of the pipetting device and the layout information of the pipetting device; finally, based on the communication configuration information, selecting corresponding execution logic information according to the task execution sequence parameters, sending the execution logic information to a first control end of the terminal 102, and sending the layout information of the pipetting equipment to a second control end of the terminal 102; the first control end is used for executing corresponding pipetting operations based on pipetting device configuration parameters and execution logic information; the second control end is used for executing corresponding layout operation based on the layout information of the pipetting equipment. The terminal 102 may be, but is not limited to, various pipetting robots, pipetting workstations, pipetting devices, and the like. The server 104 may be a personal computer, a notebook computer, a smart phone, a tablet computer, an internet of things device, and a portable wearable device, and the internet of things device may be a smart speaker, a smart television, a smart air conditioner, a smart vehicle device, and the like. The portable wearable device may be a smart watch, smart bracelet, headset, or the like.
In one embodiment, as shown in fig. 2, a pipetting control method is provided, which is described by taking the application of the method to the server 104 in fig. 1 as an example, and includes the following steps:
s202, acquiring communication configuration information, pipetting device configuration parameters, pipetting material parameters and task execution sequence parameters.
The communication configuration information refers to a set of communication configurations required for signal interaction between the server and the terminal, such as an IP address, a port number, a signal scanning period, device status acquisition, device manipulation, and the like.
The configuration parameters of the pipetting device refer to configuration parameters of various devices used in the pipetting process. Illustratively, the pipette tip is required to be completed during pipetting, and thus pipetting device configuration parameters may be set to parameters required to perform a pipette tip action, such as pipette position selection, pipette type, pipette volume parameter setting, pipette control axis parameter setting, etc.
The pipetting material parameters refer to consumable materials used in pipetting process, such as bottom plate and bracket.
The task execution sequence parameters are parameters for controlling each action in the pipetting process, and exemplary task execution sequence parameters include cycle step frequency setting, pipette tip position selection, clamping jaw carrying position selection and the like. For example, the task execution sequence parameter may be to perform a tip loading action first and then a tip unloading action.
Optionally, the server may set corresponding front end modules for various parameters, and the user may input parameters corresponding to each module at the front end interface, where the server may obtain the configuration parameters of the pipetting device set by the user for each module at the front end.
Optionally, the pipetting device configuration parameters include a pipetting configuration parameter, a pipette tip loading parameter, a pipette tip unloading parameter, a pipetting parameter and a pipetting parameter.
The pipetting configuration parameters are used for controlling parameters of the terminal to execute pipetting, and exemplary pipetting configuration parameters include parameters such as speed parameters, pipetting quantity and the like corresponding to each step, pipetting position parameters and the like.
The parameters of the suction head are parameters for controlling the terminal to execute suction head loading actions, and exemplary parameters include suction head specification parameters, position parameters, motion height configuration, suction head selection of different types and the like.
The unloading suction head parameters refer to parameters for controlling the terminal to execute the action of unloading suction heads, and exemplary unloading suction head parameters comprise parameters such as suction head specification parameters, position parameters, motion height configuration, suction head selection of different types and the like.
The liquid suction parameters refer to parameters for sucking liquid by the control terminal, and exemplary liquid suction parameters include liquid suction position selection, liquid suction groove type, liquid suction volume parameter setting and liquid suction control shaft parameter setting.
The liquid separation parameters refer to parameters for liquid separation by the control terminal, and exemplary liquid separation parameters include liquid separation position selection, liquid separation consumable selection, liquid separation volume parameter setting, liquid separation control axis parameter setting, sample blowing, mixing parameter setting and the like.
S204, generating the layout information of the pipetting equipment according to the pipetting material parameters.
The layout information of the pipetting devices refers to an information set for laying out materials in the process of performing pipetting, such as the placement position, the placement direction, the material specification and the like of various devices.
Exemplary parameters include data of the bottom plate and data of the bracket. The server generates the placement information of the pipetting device based on the parameters included in the bottom plate data and the parameters included in the holder data, e.g. the user selects a bottom plate of model I and a holder of model II, and the server generates the placement information of the pipetting device based on the bottom plate data and the holder data.
Optionally, the server may perform a matching determination on the pipetting parameters, and when the pipetting parameters match, the server may generate pipetting device layout information. When the pipetting parameters are not matched, the server can acquire the pipetting parameters again until the pipetting parameters are matched to generate pipetting equipment layout information.
S206, generating execution logic information according to the configuration parameters of the pipetting device and the layout information of the pipetting device.
The execution logic information refers to logic information of each execution action in the pipetting process, and for example, the server may first calculate the position of the first row of pipettes on the bottom plate, then sequentially calculate the positions of the second row of pipettes and the third row of pipettes … …, and then generate the execution logic information according to the arrangement sequence of the small holes, for example, pipetting the first row first, and then sequentially pipetting the subsequent rows. In other embodiments, the server pipettes the first, third, and fifth rows and generates corresponding execution logic information.
Optionally, the server first generates execution action information according to the pipetting device layout information, and then generates execution logic information according to pipetting device configuration parameters and the execution action information.
The server calculates an initial position for executing the action according to the layout information of the pipetting devices, and generates execution action information according to the layout information of the pipetting devices, for example, the server executes the action of sucking the pipette of the first row firstly and then executes the action of sucking the pipette of the first row sequentially. Then, execution logic information is generated in combination with the pipetting device configuration parameters. Illustratively, execution logic information is generated in conjunction with the execution altitude and the execution action information. The running height refers to the height of the terminal executing sucker.
S208, based on the communication configuration information, sending task execution sequence parameters, pipetting device configuration parameters and logic information to the first control end and sending pipetting device layout information to the second control end; the first control end is used for selecting corresponding execution logic information and configuration parameters of the pipetting device according to the task execution sequence parameters to execute corresponding pipetting operations; the second control end is used for executing corresponding layout operation based on the layout information of the pipetting equipment.
The first control end refers to a port for performing pipetting operations; the second control end refers to a port for arranging consumables. Illustratively, the first control end may be a pipetting arm and the first control end may be a handling arm.
Optionally, the server first establishes a communication connection between the server and the terminal according to the communication configuration information. And then the server sends various information and parameters to the corresponding execution end, and the execution end executes corresponding actions according to the parameters after acquiring the corresponding parameters.
For example, assuming that the task execution sequence parameter is to execute the suction head loading action first and then execute the suction head unloading action, the server sends the execution logic information corresponding to the suction head loading and the suction head unloading and the corresponding configuration parameter of the pipetting device to the first control end according to the task execution sequence parameter, and the first control end selects the corresponding execution logic information and the configuration parameter of the pipetting device to execute the corresponding pipetting operation according to the task execution sequence parameter. For example, firstly, according to the corresponding execution logic information of the suction head and the corresponding configuration parameters of the pipetting device, for example, the first control end performs the suction head grabbing with 50cm movement height (50 cm movement height is a parameter in the configuration parameters of the pipetting device) at the position A in combination with the execution logic information and the configuration parameters of the pipetting device, and then installs the corresponding suction head on the suction pipe at the position B, the position C and the position D of the bottom plate in sequence. After the first control end executes the action of installing the suction head, the first control end executes the corresponding action according to the execution logic information corresponding to the suction head and the pipetting configuration parameters.
Alternatively, the server may encapsulate each port according to the communication configuration information, and then the server may communicate with the terminal based on the port. The method specifically comprises initializing singlechip communication, data transmission and interface monitoring, absolute relative motion interface, zeroing motion interface, motion related parameter setting and reading interface, equipment state real-time receiving and uploading interface, jog motion executing interface, IO input/output signal acquisition and setting interface and the like.
In the above pipetting control method, the server firstly obtains the communication configuration information, the pipetting device configuration parameters, the pipetting material parameters and the task execution sequence parameters, then generates pipetting device layout information according to the pipetting material parameters, generates execution logic information according to the pipetting device configuration parameters and the pipetting device layout information, finally selects corresponding execution logic information according to the task execution sequence parameters based on the communication configuration information, sends the execution logic information to the first control end, and sends the pipetting device layout information to the second control end; the first control end is used for executing corresponding pipetting operations based on pipetting device configuration parameters and execution logic information; the second control end is used for executing corresponding layout operation based on the layout information of the pipetting equipment, so that the first control end and the second control end can perform corresponding operation according to each parameter sent by the server, no intervention of a third-party program is needed, and the interaction process of the server and the terminal is simplified.
In one embodiment, the generating the execution logic information according to the configuration parameters of the pipetting device and the pipetting device layout information includes: receiving pulse information; determining initial position information according to the pulse information; generating target position information according to the initial position information and the liquid transfer equipment layout information; and generating execution logic information according to the configuration parameters of the pipetting device and the target position information.
The initial position information refers to initial position information determined on the bottom plate, and when the bottom plate is a micro-pore plate, the initial position information may be the position of the first row of pores on the micro-pore plate, and then the position information may be the coordinates of the position of the first row of pores on the micro-pore plate; the target position information refers to position information corresponding to all the small holes on the bottom plate, wherein the target position information comprises position information of the first row of small holes and position information of the rest small holes.
Optionally, the server receives the pulse information sent by the motor, and then converts the pulse information to determine initial position information, namely, the position of the first row of holes on the bottom plate, and because the layout information of the pipetting device includes rules of the device, the distance between each row of holes can be obtained, and then the position information of all the holes on the bottom plate, namely, the target position information, can be obtained according to the initial position information and the layout information of the pipetting device.
The conversion of the pulse information by the server refers to conversion between the millimeter value on the bottom plate corresponding to the initial position information and the pulse value received by the motor end, and the proportional relationship may be 1000, for example: 1, i.e. the pulse information sent by the motor indicates 1000 pulses, the converted millimeter value on the floor is 1mm.
Optionally, after generating the target position information according to the pipetting device layout information, the server generates execution action information according to the target position information, and then generates execution logic information according to pipetting device configuration parameters and the execution action information.
The server generates execution motion information, for example, first executing a pipette tip loading motion on a pipette at a first row of positions, then executing a pipette tip loading motion on a pipette at a second row of positions, and then generating execution logic information, for example, executing a pipette tip loading motion at a high speed of 50cm motion height in combination with pipetting device configuration parameters, based on the target position information.
In the above embodiment, after generating the target position information, the server generates the execution logic information according to the configuration parameter of the pipetting device and the target position information, so that the first control end can directly execute the corresponding action according to the execution logic information after obtaining the execution logic information, thereby simplifying the pipetting operation process.
In one embodiment, after the obtaining the configuration parameters of the pipetting device, the method includes: carrying out accuracy judgment on configuration parameters of the pipetting device; accuracy judgment is carried out on configuration parameters of the pipetting device, and the method comprises the following steps: when the configuration parameters of the pipetting device are within the preset parameter range, generating execution logic information according to the configuration parameters of the pipetting device, the layout information of the pipetting device and the pipetting material parameters; and when the configuration parameters of the pipetting device are not in the preset parameter range, re-acquiring the configuration parameters of the pipetting device.
The preset parameter range refers to a preset range of configuration parameters of the pipetting device, and is a basis for judging whether the configuration parameters of the pipetting device are accurate.
Optionally, after obtaining the configuration parameters of the pipetting device, the server may determine the accuracy of the configuration parameters of the pipetting device. Specifically, when the configuration parameters of the pipetting device are within the preset parameter range, generating execution logic information according to the configuration parameters of the pipetting device, the layout information of the pipetting device and the parameters of the pipetting material; and when the configuration parameters of the pipetting device are not in the preset parameter range, re-acquiring the configuration parameters of the pipetting device.
Optionally, each execution action in the configuration parameters of the pipetting device, that is, pipetting, pipette tip loading, pipette tip unloading, pipetting and pipetting corresponds to a corresponding preset parameter range, and the preset parameter range corresponding to each execution action can be set according to the actual execution action.
For example, the range of the preset parameter corresponding to the pipetting is [1,10], and when the parameter corresponding to the pipetting obtained by the server is 12, the range of the preset parameter is exceeded, so that the parameter corresponding to the pipetting needs to be obtained again until the range of the preset parameter is met.
Optionally, when the configuration parameters of the pipetting device are not in the preset parameter range, the server pops up the prompt information, and the user can input the strived pipetting device parameters according to the prompt information.
In the embodiment, the server performs accuracy judgment on the configuration parameters of the pipetting device, so that the parameters of the pipetting device input into the server can be ensured to be accurate, and pipetting operation failure caused by inaccurate parameters is reduced.
In one embodiment, the pipetting material parameters include floor data and rack data; generating pipetting device layout information according to pipetting material parameter parameters, comprising: when the bottom plate data and the bracket data meet a first preset matching condition, consumable data are acquired; and when the consumable data and the bracket data meet a second preset matching condition, generating the layout information of the pipetting equipment.
The first preset matching condition is a preset judging condition for judging whether the bottom plate data and the bracket data are matched or not. The first preset matching condition may be a parameter range or a preset threshold value; the second preset matching condition is a preset judging condition for judging whether the consumable data and the bracket data are matched or not. The second preset matching condition may be a parameter range or a preset threshold.
The server obtains the base plate data and the bracket data, judges whether the base plate data and the bracket data are matched according to a first preset matching condition, and continuously executes the step of obtaining consumable data when the base plate data are matched with the bracket data. After the step of acquiring the consumable data, the server judges whether the consumable data is matched with the bracket data, and when the consumable data is matched with the bracket data, the server generates the layout information of the pipetting equipment.
When the bottom plate data is not matched with the bracket data, the server returns error information to acquire the next bracket data until the acquired bracket data meets a first preset matching condition; and when the consumable data is not matched with the bracket data, acquiring lower consumable data until the acquired consumable data accords with a first preset matching condition. FIG. 3, which may be combined with FIG. 3, is a schematic diagram illustrating the generation of placement information for a pipetting device in one embodiment.
In the above embodiment, the server may sequentially perform matching judgment on the base plate data and the support data, and on the support data and the consumable data, and only when the base plate data and the support data are matched with the consumable data, the layout information of the pipetting device may be generated, so that the pipetting operation may be ensured to be completed in a proper way.
In one embodiment, the method further comprises acquiring a status semaphore; and generating an alarm signal according to the state signal quantity.
The state signal quantity refers to the signal quantity sent by the terminal in the running process. Alternatively, the state semaphores sent by the different components are of different types, e.g. the state semaphore sent by the first control terminal may be an alpha-type semaphore state quantity; the state signal quantity sent by the second control terminal may be a β -type signal state quantity.
Optionally, the server extracts a type identifier in the state semaphore and then distinguishes the type of the semaphore according to the type identifier. The type identifier is carried in the finger state semaphore and is used for distinguishing the identifier of the state semaphore type by the server.
The server generates a corresponding alarm signal according to the state signal quantity, wherein the alarm signal plays a role in warning in the pipetting process.
Alternatively, the alarm signal may be cleared after the server has handled the exception condition.
In the above embodiment, the server generates the corresponding alarm signal according to the status signal quantity, so as to play a role in warning the user, so that the user can intervene in the pipetting process in time.
In an exemplary embodiment, with reference to fig. 4, fig. 4 is a schematic diagram of the steps of a liquid control method in one embodiment.
First, the server initializes the terminal configuration, such as initializing device communications, device parameters, and device status reset to a waiting state. Edit data, i.e., communication configuration information and control axis configuration information, is then acquired. The control shaft configuration information is used for controlling the parameter setting of the relevant information of each control shaft, and comprises a shaft number, a shaft name, a screw pitch, a pulse ratio, a maximum and minimum speed, acceleration and deceleration time, a zero return initial speed, an approaching speed and a positive limit position and a negative limit position. Note that the communication configuration information and the control axis configuration information need to be configured only once.
Next, the server acquires the editing scheme, i.e., the input parameters of each module, such as the configuration parameters of the liquid apparatus, the parameters of the pipetting materials, and the execution sequence parameters of the tasks, and then generates the pipetting device layout information for the pipetting material parameters, and the process of specifically generating the pipetting device layout information can refer to the steps described in any one of the embodiments above. And judging whether the scheme is editable or not, namely judging the accuracy of the parameters of each module, generating execution logic information by each module when the scheme is editable, and finally transmitting each module parameter, task execution sequence parameter and execution logic information to the terminal by the server based on the edit data, wherein the terminal selects the corresponding execution logic information and each module parameter according to the task execution sequence parameter for execution.
In the embodiment, the logic flow is easy to control, compared with the traditional PLC control equipment, the hardware cost is reduced, the upper computer developer is easier to comprehensively control all flow designs of the equipment, complicated signal interaction is omitted relative to the PLC, the software and the hardware can directly perform interactive operation, the intervention of a third-party program is omitted, and the later maintenance personnel are easier to control and modify.
It should be understood that, although the steps in the flowcharts related to the embodiments described above are sequentially shown as indicated by arrows, these steps are not necessarily sequentially performed in the order indicated by the arrows. The steps are not strictly limited to the order of execution unless explicitly recited herein, and the steps may be executed in other orders. Moreover, at least some of the steps in the flowcharts described in the above embodiments may include a plurality of steps or a plurality of stages, which are not necessarily performed at the same time, but may be performed at different times, and the order of the steps or stages is not necessarily performed sequentially, but may be performed alternately or alternately with at least some of the other steps or stages.
Based on the same inventive concept, the embodiment of the application also provides a pipetting control device for realizing the pipetting control method. The implementation of the solution provided by the device is similar to the implementation described in the above method, so the specific limitations in one or more embodiments of the pipetting control device provided below may be referred to above for limitations of the pipetting control method, and will not be repeated here.
In one embodiment, as shown in fig. 5, there is provided a pipetting control device comprising: an acquisition module 100, a layout module 200, a logic module 300, and a control module 400, wherein:
the acquisition module 100 is configured to acquire communication configuration information, a pipetting device configuration parameter, a pipetting material parameter, and a task execution sequence parameter.
The layout module 200 is used for generating the layout information of the pipetting device according to the pipetting material parameters.
The logic module 300 is configured to generate execution logic information according to the configuration parameters of the pipetting device and the pipetting device layout information.
The control module 400 is configured to send the task execution sequence parameter, the pipetting device configuration parameter and the logic information to the first control end and send the pipetting device layout information to the second control end based on the communication configuration information; the first control end is used for selecting corresponding execution logic information and configuration parameters of the pipetting device according to the task execution sequence parameters to execute corresponding pipetting operations; the second control end is used for executing corresponding layout operation based on the layout information of the pipetting equipment.
In one embodiment, the logic module 300 includes:
and the receiving unit is used for receiving the pulse information.
And the position determining unit is used for determining initial position information according to the pulse information.
And the target position unit is used for generating target position information according to the initial position information and the liquid transferring equipment layout information.
And the logic generation unit is used for generating execution logic information according to the configuration parameters of the pipetting device and the target position information.
In one embodiment, the apparatus further comprises:
and the accuracy judgment module is used for accurately judging the configuration parameters of the pipetting device.
In one embodiment, the accurate determination module includes:
and the first range judging unit is used for generating execution logic information according to the configuration parameters of the pipetting device, the layout information of the pipetting device and the pipetting material parameters when the configuration parameters of the pipetting device are in the preset parameter range.
And the second range judging unit is used for acquiring the configuration parameters of the pipetting device again when the configuration parameters of the pipetting device are not in the preset parameter range.
In one embodiment, the layout module 200 includes:
and the consumable acquisition unit is used for acquiring consumable data when the bottom plate data and the bracket data meet a first preset matching condition.
And the layout generating unit is used for generating the layout information of the pipetting equipment when the consumable data and the bracket data meet the second preset matching condition.
In one embodiment, the apparatus further comprises:
and the signal acquisition unit is used for acquiring the state signal quantity.
And the alarm generating unit is used for generating an alarm signal according to the state signal quantity.
The respective modules in the pipetting control apparatus described above may be realized in whole or in part by software, hardware, and a combination thereof. The above modules may be embedded in hardware or may be independent of a processor in the computer device, or may be stored in software in a memory in the computer device, so that the processor may call and execute operations corresponding to the above modules.
In one embodiment, a computer device is provided, which may be a server, the internal structure of which may be as shown in fig. 6. The computer device includes a processor, a memory, an Input/Output interface (I/O) and a communication interface. The processor, the memory and the input/output interface are connected through a system bus, and the communication interface is connected to the system bus through the input/output interface. Wherein the processor of the computer device is configured to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system, computer programs, and a database. The internal memory provides an environment for the operation of the operating system and computer programs in the non-volatile storage media. The database of the computer device is used for storing configuration information, configuration parameters of the pipetting device, pipetting material parameters and task execution sequence parameters. The input/output interface of the computer device is used to exchange information between the processor and the external device. The communication interface of the computer device is used for communicating with an external terminal through a network connection. The computer program is executed by a processor to implement a pipetting control method.
It will be appreciated by those skilled in the art that the structure shown in fig. 6 is merely a block diagram of some of the structures associated with the present application and is not limiting of the computer device to which the present application may be applied, and that a particular computer device may include more or fewer components than shown, or may combine certain components, or have a different arrangement of components.
In one embodiment, a computer device is provided comprising a memory and a processor, the memory having stored therein a computer program, the processor when executing the computer program performing the steps of: acquiring communication configuration information, pipetting device configuration parameters, pipetting material parameters and task execution sequence parameters; generating layout information of the pipetting equipment according to the pipetting material parameters; generating execution logic information according to the configuration parameters of the pipetting device and the layout information of the pipetting device; based on the communication configuration information, sending task execution sequence parameters, pipetting device configuration parameters and logic information to a first control end, and sending pipetting device layout information to a second control end; the first control end is used for selecting corresponding execution logic information and configuration parameters of the pipetting device according to the task execution sequence parameters to execute corresponding pipetting operations; the second control end is used for executing corresponding layout operation based on the layout information of the pipetting equipment.
In one embodiment, the processor, when executing the computer program, generates execution logic information according to the pipetting device configuration parameters and the pipetting device layout information, including: receiving pulse information; determining initial position information according to the pulse information; generating target position information according to the initial position information and the liquid transfer equipment layout information; and generating execution logic information according to the configuration parameters of the pipetting device and the target position information.
In one embodiment, after obtaining the pipetting device configuration parameters implemented when the processor executes the computer program, it comprises: carrying out accuracy judgment on configuration parameters of the pipetting device; accuracy judgment is carried out on configuration parameters of the pipetting device, and the method comprises the following steps: when the configuration parameters of the pipetting device are within the preset parameter range, generating execution logic information according to the configuration parameters of the pipetting device, the layout information of the pipetting device and the pipetting material parameters; and when the configuration parameters of the pipetting device are not in the preset parameter range, re-acquiring the configuration parameters of the pipetting device.
In one embodiment, the pipetting material parameters implemented when the processor executes the computer program include floor data and rack data; generating pipetting device layout information according to pipetting material parameter parameters, comprising: when the bottom plate data and the bracket data meet a first preset matching condition, consumable data are acquired; and when the consumable data and the bracket data meet a second preset matching condition, generating the layout information of the pipetting equipment.
In one embodiment, the implementation of the computer program when executed by the processor further includes: acquiring a state signal quantity; and generating an alarm signal according to the state signal quantity.
In one embodiment, the pipetting device configuration parameters include a pipetting configuration parameter, a pipette tip loading parameter, a pipette tip unloading parameter, a pipetting parameter and a pipetting parameter.
In one embodiment, a computer readable storage medium is provided having a computer program stored thereon, which when executed by a processor, performs the steps of: acquiring communication configuration information, pipetting device configuration parameters, pipetting material parameters and task execution sequence parameters; generating layout information of the pipetting equipment according to the pipetting material parameters; generating execution logic information according to the configuration parameters of the pipetting device and the layout information of the pipetting device; based on the communication configuration information, sending task execution sequence parameters, pipetting device configuration parameters and logic information to a first control end, and sending pipetting device layout information to a second control end; the first control end is used for selecting corresponding execution logic information and configuration parameters of the pipetting device according to the task execution sequence parameters to execute corresponding pipetting operations; the second control end is used for executing corresponding layout operation based on the layout information of the pipetting equipment.
In one embodiment, the computer program, when executed by the processor, generates execution logic information according to pipetting device configuration parameters and pipetting device layout information, comprising: receiving pulse information; determining initial position information according to the pulse information; generating target position information according to the initial position information and the liquid transfer equipment layout information; and generating execution logic information according to the configuration parameters of the pipetting device and the target position information.
In one embodiment, after obtaining pipetting device configuration parameters, which is implemented when the computer program is executed by the processor, comprises: carrying out accuracy judgment on configuration parameters of the pipetting device; accuracy judgment is carried out on configuration parameters of the pipetting device, and the method comprises the following steps: when the configuration parameters of the pipetting device are within the preset parameter range, generating execution logic information according to the configuration parameters of the pipetting device, the layout information of the pipetting device and the pipetting material parameters; and when the configuration parameters of the pipetting device are not in the preset parameter range, re-acquiring the configuration parameters of the pipetting device.
In one embodiment, the pipetting material parameters implemented when the computer program is executed by the processor include floor data and rack data; generating pipetting device layout information according to pipetting material parameter parameters, comprising: when the bottom plate data and the bracket data meet a first preset matching condition, consumable data are acquired; and when the consumable data and the bracket data meet a second preset matching condition, generating the layout information of the pipetting equipment.
In one embodiment, the computer program when executed by the processor further comprises: acquiring a state signal quantity; and generating an alarm signal according to the state signal quantity.
In one embodiment, the pipetting device configuration parameters implemented when the computer program is executed by the processor include a pipetting configuration parameter, a pipette tip loading parameter, a pipette tip unloading parameter, a pipette tip loading parameter, and a pipetting parameter.
In one embodiment, a computer program product is provided comprising a computer program which, when executed by a processor, performs the steps of: acquiring communication configuration information, pipetting device configuration parameters, pipetting material parameters and task execution sequence parameters; generating layout information of the pipetting equipment according to the pipetting material parameters; generating execution logic information according to the configuration parameters of the pipetting device and the layout information of the pipetting device; based on the communication configuration information, sending task execution sequence parameters, pipetting device configuration parameters and logic information to a first control end, and sending pipetting device layout information to a second control end; the first control end is used for selecting corresponding execution logic information and configuration parameters of the pipetting device according to the task execution sequence parameters to execute corresponding pipetting operations; the second control end is used for executing corresponding layout operation based on the layout information of the pipetting equipment.
In one embodiment, the computer program, when executed by the processor, generates execution logic information according to pipetting device configuration parameters and pipetting device layout information, comprising: receiving pulse information; determining initial position information according to the pulse information; generating target position information according to the initial position information and the liquid transfer equipment layout information; and generating execution logic information according to the configuration parameters of the pipetting device and the target position information.
In one embodiment, after obtaining pipetting device configuration parameters, which is implemented when the computer program is executed by the processor, comprises: carrying out accuracy judgment on configuration parameters of the pipetting device; accuracy judgment is carried out on configuration parameters of the pipetting device, and the method comprises the following steps: when the configuration parameters of the pipetting device are within the preset parameter range, generating execution logic information according to the configuration parameters of the pipetting device, the layout information of the pipetting device and the pipetting material parameters; and when the configuration parameters of the pipetting device are not in the preset parameter range, re-acquiring the configuration parameters of the pipetting device.
In one embodiment, the pipetting material parameters implemented when the computer program is executed by the processor include floor data and rack data; generating pipetting device layout information according to pipetting material parameters, comprising: when the bottom plate data and the bracket data meet a first preset matching condition, consumable data are acquired; and when the consumable data and the bracket data meet a second preset matching condition, generating the layout information of the pipetting equipment.
In one embodiment, the computer program when executed by the processor further comprises: acquiring a state signal quantity; and generating an alarm signal according to the state signal quantity.
In one embodiment, the pipetting device configuration parameters implemented when the computer program is executed by the processor include a pipetting configuration parameter, a pipette tip loading parameter, a pipette tip unloading parameter, a pipette tip loading parameter, and a pipetting parameter.
It should be noted that, the user information (including, but not limited to, user equipment information, user personal information, etc.) and the data (including, but not limited to, data for analysis, stored data, presented data, etc.) referred to in the present application are information and data authorized by the user or sufficiently authorized by each party, and the collection, use and processing of the related data are required to comply with the related laws and regulations and standards of the related countries and regions.
Those skilled in the art will appreciate that implementing all or part of the above described methods may be accomplished by way of a computer program stored on a non-transitory computer readable storage medium, which when executed, may comprise the steps of the embodiments of the methods described above. Any reference to memory, database, or other medium used in the various embodiments provided herein may include at least one of non-volatile and volatile memory. The nonvolatile Memory may include Read-Only Memory (ROM), magnetic tape, floppy disk, flash Memory, optical Memory, high density embedded nonvolatile Memory, resistive random access Memory (ReRAM), magnetic random access Memory (Magnetoresistive Random Access Memory, MRAM), ferroelectric Memory (Ferroelectric Random Access Memory, FRAM), phase change Memory (Phase Change Memory, PCM), graphene Memory, and the like. Volatile memory can include random access memory (Random Access Memory, RAM) or external cache memory, and the like. By way of illustration, and not limitation, RAM can be in the form of a variety of forms, such as static random access memory (Static Random Access Memory, SRAM) or dynamic random access memory (Dynamic Random Access Memory, DRAM), and the like. The databases referred to in the various embodiments provided herein may include at least one of relational databases and non-relational databases. The non-relational database may include, but is not limited to, a blockchain-based distributed database, and the like. The processors referred to in the embodiments provided herein may be general purpose processors, central processing units, graphics processors, digital signal processors, programmable logic units, quantum computing-based data processing logic units, etc., without being limited thereto.
The technical features of the above embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The above examples only represent a few embodiments of the present application, which are described in more detail and are not to be construed as limiting the scope of the present application. It should be noted that it would be apparent to those skilled in the art that various modifications and improvements could be made without departing from the spirit of the present application, which would be within the scope of the present application. Accordingly, the scope of protection of the present application shall be subject to the appended claims.

Claims (10)

1. A pipetting control method, characterized by being applied to a server, the method comprising:
acquiring communication configuration information, pipetting device configuration parameters, pipetting material parameters and task execution sequence parameters;
generating layout information of the pipetting equipment according to the pipetting material parameters;
generating execution logic information according to the configuration parameters of the pipetting device and the pipetting device layout information;
Based on the communication configuration information, sending task execution sequence parameters, pipetting device configuration parameters and logic information to a first control end, and sending the pipetting device layout information to a second control end; the first control end is used for selecting corresponding execution logic information and configuration parameters of the pipetting device according to the task execution sequence parameters to execute corresponding pipetting operations; the second control end is used for executing corresponding layout operation based on the liquid transfer equipment layout information.
2. The method of claim 1, wherein generating execution logic information based on the pipetting device configuration parameters and the pipetting device layout information comprises:
receiving pulse information;
determining initial position information according to the pulse information;
generating target position information according to the initial position information and the pipetting device layout information;
and generating execution logic information according to the configuration parameters of the pipetting device and the target position information.
3. The solution according to claim 1, characterized in that after the acquisition of the pipetting device configuration parameters, it comprises:
carrying out accuracy judgment on the configuration parameters of the pipetting device;
The performing accuracy judgment on the configuration parameters of the pipetting device includes:
when the configuration parameters of the pipetting device are within the preset parameter range, generating execution logic information according to the configuration parameters of the pipetting device, the layout information of the pipetting device and the pipetting material parameters;
and when the configuration parameters of the pipetting device are not in the preset parameter range, re-acquiring the configuration parameters of the pipetting device.
4. The method of claim 1, wherein the pipetting material parameters include floor data and rack data; generating the layout information of the pipetting device according to the pipetting material parameter parameters comprises the following steps:
acquiring consumable data when the bottom plate data and the bracket data meet a first preset matching condition;
and when the consumable data and the bracket data meet a second preset matching condition, generating the layout information of the pipetting equipment.
5. The method according to claim 1, wherein the method further comprises:
acquiring a state signal quantity;
and generating an alarm signal according to the state signal quantity.
6. The method of any one of claims 1 to 5, wherein the pipetting device configuration parameters include a pipetting configuration parameter, a pipette tip loading parameter, a pipette tip unloading parameter, a pipette tip loading parameter, and a pipetting parameter.
7. A pipetting control device, the device comprising:
the acquisition module is used for acquiring communication configuration information, pipetting device configuration parameters, pipetting material parameters and task execution sequence parameters;
the layout module is used for generating layout information of the pipetting equipment according to the pipetting material parameters;
the logic module is used for generating execution logic information according to the configuration parameters of the pipetting device and the pipetting device layout information;
the control module is used for sending the task execution sequence parameters, the pipetting device configuration parameters and the logic information to the first control end based on the communication configuration information, and sending the pipetting device layout information to the second control end; the first control end is used for selecting corresponding execution logic information and configuration parameters of the pipetting device according to the task execution sequence parameters to execute corresponding pipetting operations; the second control end is used for executing corresponding layout operation based on the liquid transfer equipment layout information.
8. A computer device comprising a memory and a processor, the memory storing a computer program, characterized in that the processor implements the steps of the method of any of claims 1 to 6 when the computer program is executed.
9. A computer readable storage medium, on which a computer program is stored, characterized in that the computer program, when being executed by a processor, implements the steps of the method of any of claims 1 to 6.
10. A computer program product comprising a computer program, characterized in that the computer program, when being executed by a processor, implements the steps of the method of any of claims 1 to 6.
CN202310186977.6A 2023-03-01 2023-03-01 Pipetting control method, pipetting control device, computer equipment and storage medium Pending CN116184922A (en)

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