CN116184648A - Slide glass scanning device - Google Patents
Slide glass scanning device Download PDFInfo
- Publication number
- CN116184648A CN116184648A CN202310116620.0A CN202310116620A CN116184648A CN 116184648 A CN116184648 A CN 116184648A CN 202310116620 A CN202310116620 A CN 202310116620A CN 116184648 A CN116184648 A CN 116184648A
- Authority
- CN
- China
- Prior art keywords
- scanning
- linear
- slide
- lens
- photoelectric component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/361—Optical details, e.g. image relay to the camera or image sensor
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/365—Control or image processing arrangements for digital or video microscopes
Landscapes
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Multimedia (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Mechanical Optical Scanning Systems (AREA)
Abstract
The invention discloses a slide glass scanning device, which relates to the technical field of scanning devices, and comprises a linear photoelectric component and a cylindrical lens, wherein the cylindrical lens is fixed at the scanning end of the linear photoelectric component, and the middle part of the cross section of the cylindrical lens is thicker than the two side parts. The invention realizes information acquisition of the glass slide by utilizing the linear photoelectric component through the columnar lens, the whole process can scan the glass slide only by moving along the linear direction, the whole scanning process is faster, the structure is simple, and the manufacturing cost is low.
Description
Technical Field
The invention relates to the technical field of scanning devices, in particular to a slide scanning device.
Background
The materials to be observed are collected on a glass slide, and observed by a microscope, which is a common method for researching the microscopic world. For example, in the case of examination, red blood cells, secretions, etc. are smeared on a slide glass, and observed with a microscope to examine morphological abnormal cells or bacterial infection, etc. For example, in pathology, a sample is cut into an ultrathin section, then the ultrathin section is shoal on a glass slide, and the ultrathin section is observed by a microscope, so that canceration or other lesions are diagnosed. Therefore, the specimen of the slide is preserved, which is a necessary task. For example, the slide glass of the pathology positive sample needs to be stored for more than 20 years, so that the slide glass is convenient for archiving and research and use.
Conventionally, glass slide samples have been mounted with special glue, such as neutral gum, to isolate the air and prevent damage to the sample due to oxidation. The original preservation method has a plurality of defects, such as large occupied space, need to be maintained by special persons and the like. With the development of digital technology, digital slicing systems have emerged. In popular terms, the prepared slide glass is scanned by an automatic scanning microscope under a specified magnification to form clear pictures of various fields of view, and finally a digital image containing all scanning areas is synthesized by a computer. Thus, the tangible slide can be converted into a digital image for long-term storage.
The advent of digital slicing systems has fundamentally changed the traditional methods of preserving slides. The method has the advantages of small occupied space, extremely long preservation time, no change of sample images along with the time, convenience in automatic analysis of the images and the like, and has become a future trend.
As can be seen from the foregoing, the key technology of the digital slicing system is the scanning system. The working principle and method of the scanning system directly determine the quality and efficiency of the digital slide. Especially for large batches of slides, and more particularly to the quality and efficiency of the scan.
A typical digital slicing system consists of four parts, namely an optical imaging system, a digital imaging system, a servo system and a computer system. The optical imaging system optically amplifies the glass slide to clear images by means of a servo system, the digital imaging system performs photoelectric conversion to generate digital images, and finally the computer system performs synthesis processing. It can be seen that the optical imaging system is a data source, and directly determines the image quality and the data quality.
The existing optical imaging systems are all mature optical microscope systems. On the one hand, because the optical microscopy technology is already very mature, and on the other hand, the quality of the optical system can be fully ensured.
Originally, the microscope was designed to fit the human eye, and therefore a circular lens was used, resulting in a natural circular field of view. The current digital slicing system directly borrows the optical structure of the conventional microscope, so that the circular image has to be processed.
The disadvantages of circular fields of view are numerous:
1) The microscope objective lens needs to be moved frequently to ensure continuous photographing;
2) Because the slide glass scanning area is a two-dimensional plane, the microscope objective lens needs to move in the X-Y two axial directions to ensure that the area is not missed;
3) As only one circular area can be shot at a time, the non-coincident areas of two adjacent fields of view are practically omitted, and if the non-coincident areas are not omitted, a large number of coincident scanning can be only carried out;
4) Because the current microscope adopts a round lens, the microscope is of a single-lens structure, that is, only one round lens can be used for sweeping one round lens, and multi-view synchronous scanning cannot be achieved;
the above list only a few drawbacks.
It can be seen that the current microscope system is developed to cater for human eyes, rather than for automatic scanning, so that the current digital slicing system has low scanning efficiency and complex servo structure. Scanning a standard slide, at current common speeds, is done for an average of 5 minutes, failing to meet the current huge slide count. And the synchronous scanning of a plurality of instruments is adopted, so that the use cost is obviously greatly increased, and the method is not a fundamental way for solving the problem.
Therefore, there is an urgent need in the market for a slide scanning device to solve the above-mentioned problems.
Disclosure of Invention
The invention aims to provide a glass slide scanning device which is used for solving the technical problems in the prior art and can realize the technical effect of rapid scanning by utilizing a linear photoelectric component and a cylindrical lens.
In order to achieve the above object, the present invention provides the following solutions:
the invention discloses a slide glass scanning device which comprises a linear photoelectric component and a columnar lens, wherein the columnar lens is fixed at the scanning end of the linear photoelectric component, the middle part of the cross section of the columnar lens is thicker than the two side parts, and the linear photoelectric component can drive the columnar lens to move along a straight line.
Preferably, the linear electro-optical component is a linear CCD in a scanner.
Compared with the prior art, the invention has the following technical effects:
the invention can scan the glass slide without dead angle by utilizing the linear movement of the linear photoelectric component and the columnar lens, the whole process only needs to move along one direction, the scanning working efficiency is higher, the whole structure is simple, and the manufacturing cost is low.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic view of a slide scanning device according to an embodiment of the present invention;
in the figure: 1-a linear optoelectronic component; 2-lenticular lens.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The invention aims to provide a glass slide scanning device which is used for solving the technical problems in the prior art and can realize the technical effect of rapid scanning by utilizing a linear photoelectric component and a cylindrical lens.
In order that the above-recited objects, features and advantages of the present invention will become more readily apparent, a more particular description of the invention will be rendered by reference to the appended drawings and appended detailed description.
As shown in fig. 1, the present embodiment provides a slide scanning device, which includes a linear photoelectric component 1 and a lenticular lens 2, wherein the linear photoelectric component 1 is a conventional scanning mechanism having a long strip shape, and the lenticular lens 2 is fixed at a scanning end of the linear photoelectric component 1. The length of the columnar lens 2 is larger than or equal to the width of the glass slide to be scanned, the specific size can be adjusted according to the width of the glass slide, the middle part of the cross section of the columnar lens 2 is thicker than the two side parts, and the cross section shape of the columnar lens is the same as that of the traditional convex lens, so that the scanning range of the linear photoelectric component 1 is increased, and the problem of leakage scanning is avoided. The linear photoelectric component 1 can drive the cylindrical lens 2 to move along a straight line, and compared with the bidirectional movement of the X-Y axis of the existing microscope structure, the structure reduces the movement path, thereby improving the working efficiency.
In actual use, the linear photoelectric component 1 is utilized to drive the cylindrical lens 2 to synchronously move, and the cylindrical lens 2 is utilized to improve the scanning range of the linear photoelectric component 1. Since the length of the lenticular lens 2 and the linear electro-optical element 1 is longer than the width of the region to be scanned, scanning is only required in one direction, and no dead angle is generated. After the scanning is finished, the linear photoelectric component 1 transmits scanning information to a computer for information processing.
In the present embodiment, the linear photoelectric component 1 is a linear CCD in the scanner, and the lenticular lens 2 is disposed between the linear CCD and the carrier glass of the scanner. In actual use, the lenticular lens 2 can increase the scanning range of the linear CCD for the object to be scanned on which the glass is carried, and it can move in synchronization with the linear CCD.
Furthermore, the linear electro-optical component 1 may also be a linear scanner, which uses a manual grip or other means to scan the item to be scanned. Of course, the linear electro-optical component 1 may be other scanning devices, and is not limited to the linear CCD or the linear scanner in the present embodiment.
The principles and embodiments of the present invention have been described in this specification with reference to specific examples, the description of which is only for the purpose of aiding in understanding the method of the present invention and its core ideas; also, it is within the scope of the present invention to be modified by those of ordinary skill in the art in light of the present teachings. In view of the foregoing, this description should not be construed as limiting the invention.
Claims (2)
1. A slide scanning device, characterized by: the linear photoelectric component and the columnar lens are fixed at the scanning end of the linear photoelectric component, the middle part of the cross section of the columnar lens is thicker than the two side parts, and the linear photoelectric component can drive the columnar lens to move along a straight line.
2. The slide scanning device of claim 1, wherein: the linear electro-optical component is a linear CCD in the scanner.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310116620.0A CN116184648A (en) | 2023-01-30 | 2023-01-30 | Slide glass scanning device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310116620.0A CN116184648A (en) | 2023-01-30 | 2023-01-30 | Slide glass scanning device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116184648A true CN116184648A (en) | 2023-05-30 |
Family
ID=86437889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310116620.0A Pending CN116184648A (en) | 2023-01-30 | 2023-01-30 | Slide glass scanning device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116184648A (en) |
-
2023
- 2023-01-30 CN CN202310116620.0A patent/CN116184648A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Voie et al. | Orthogonal‐plane fluorescence optical sectioning: Three‐dimensional imaging of macroscopic biological specimens | |
| US6320174B1 (en) | Composing microscope | |
| US8059336B2 (en) | Rapid microscope scanner for volume image acquisition | |
| CN101375786B (en) | Fluorescence endoscopic imaging method and device | |
| CN204188877U (en) | Based on the panoramic scanning device of the micro-image of photoetching slide | |
| US20120120221A1 (en) | Body Fluid Analyzing System and an Imaging Processing Device and Method for Analyzing Body Fluids | |
| CN104111242A (en) | Three dimensional pixel super-resolution microscopic imaging method | |
| CA2641635A1 (en) | Method and apparatus and computer program product for collecting digital image data from microscope media-based specimens | |
| TWI817063B (en) | Digital imaging system and method | |
| CN111406218B (en) | Fixed datum edge system for slide loading and unloading | |
| CN111183387B (en) | Opposed edge system for scanning and processing glass slides | |
| JP2020525848A (en) | Adjustable slide stage for different size slides | |
| CN106324820A (en) | Image processing-based automatic focusing method applied to dual-channel fluorescence optical microscopic imaging | |
| CN111665617A (en) | Focusing method and system | |
| US11373366B2 (en) | Method for improving modeling speed of digital slide scanner | |
| CN108937909B (en) | Layer-selecting blood flow speckle imaging device and method based on lamellar light | |
| CN109061865A (en) | It is a kind of can auto-focusing more multiplying power microscopic structures | |
| CN116184648A (en) | Slide glass scanning device | |
| CN111175301B (en) | Clear image acquisition method for sheath flow microscopic full-thickness flow channel cells | |
| US20200358946A1 (en) | Methods and Systems for Single Frame Autofocusing Based on Color-Multiplexed Illumination | |
| CN203083858U (en) | Device for remotely obtaining digital slice from glass slice | |
| CN110243827B (en) | Rapid three-dimensional imaging method suitable for light transparent sample | |
| US7476831B2 (en) | Microscopic imaging system having an optical correcting element | |
| CN112345317B (en) | Liquid-based cell slide scanning and reading mechanism and using method thereof | |
| CN209656982U (en) | A kind of automatic focusing mechanism for micro-vision system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |