CN116144123A - Chlorinated butyl rubber plug for in-vitro diagnostic reagent and preparation method thereof - Google Patents
Chlorinated butyl rubber plug for in-vitro diagnostic reagent and preparation method thereof Download PDFInfo
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- CN116144123A CN116144123A CN202310147832.5A CN202310147832A CN116144123A CN 116144123 A CN116144123 A CN 116144123A CN 202310147832 A CN202310147832 A CN 202310147832A CN 116144123 A CN116144123 A CN 116144123A
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- butyl rubber
- chlorinated butyl
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- 229920005556 chlorobutyl Polymers 0.000 title claims abstract description 78
- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 62
- 238000000338 in vitro Methods 0.000 title claims abstract description 62
- 238000002360 preparation method Methods 0.000 title abstract description 16
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 57
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims abstract description 40
- 239000006229 carbon black Substances 0.000 claims abstract description 40
- 239000011787 zinc oxide Substances 0.000 claims abstract description 29
- LLMZOZPIRWJOPO-UHFFFAOYSA-N C(C)(C)(CC)C12C(C3C(C=C1)(O)S3)S2 Chemical compound C(C)(C)(CC)C12C(C3C(C=C1)(O)S3)S2 LLMZOZPIRWJOPO-UHFFFAOYSA-N 0.000 claims abstract description 25
- 239000000395 magnesium oxide Substances 0.000 claims abstract description 24
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims abstract description 24
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000005995 Aluminium silicate Substances 0.000 claims abstract description 20
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 235000012211 aluminium silicate Nutrition 0.000 claims abstract description 20
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims abstract description 20
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000004408 titanium dioxide Substances 0.000 claims abstract description 20
- 238000004806 packaging method and process Methods 0.000 claims description 21
- 239000002994 raw material Substances 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 11
- 238000004140 cleaning Methods 0.000 claims description 10
- 238000003801 milling Methods 0.000 claims description 10
- 230000008569 process Effects 0.000 claims description 10
- 238000004080 punching Methods 0.000 claims description 10
- 238000005475 siliconizing Methods 0.000 claims description 10
- 238000004073 vulcanization Methods 0.000 abstract description 8
- 229920001971 elastomer Polymers 0.000 abstract description 6
- 238000004132 cross linking Methods 0.000 abstract description 2
- 238000009776 industrial production Methods 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 9
- 239000000126 substance Substances 0.000 description 3
- 206010018910 Haemolysis Diseases 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- CMHURKNPNRMCAL-UHFFFAOYSA-N [O-2].O.[Mg+2].S Chemical compound [O-2].O.[Mg+2].S CMHURKNPNRMCAL-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229920005557 bromobutyl Polymers 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920005555 halobutyl Polymers 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D39/00—Closures arranged within necks or pouring openings or in discharge apertures, e.g. stoppers
- B65D39/0005—Closures arranged within necks or pouring openings or in discharge apertures, e.g. stoppers made in one piece
- B65D39/0041—Bungs, e.g. wooden or rubber, for barrels or the like
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/36—Sulfur-, selenium-, or tellurium-containing compounds
- C08K5/37—Thiols
- C08K5/375—Thiols containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2217—Oxides; Hydroxides of metals of magnesium
- C08K2003/222—Magnesia, i.e. magnesium oxide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2296—Oxides; Hydroxides of metals of zinc
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Mechanical Engineering (AREA)
- Dental Preparations (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
The invention discloses a chlorinated butyl rubber plug for an in-vitro diagnostic reagent and a preparation method thereof, belonging to the technical field of medical equipment. The chlorinated butyl rubber plug for the in-vitro diagnostic reagent comprises the following components in parts by weight: 100 parts of chlorinated butyl rubber, 60-80 parts of calcined kaolin, 1-3 parts of titanium dioxide, 0.2-0.4 part of carbon black, 4-6 parts of zinc oxide, 0.4-0.8 part of magnesium oxide, 5-7 parts of talcum powder, 4-6 parts of white carbon black and 0.8-1 part of p-tert-amyl phenol disulfide. The invention provides a rubber plug capable of meeting the requirements of in-vitro diagnostic reagents, a vulcanization system of p-tert-amyl phenol disulfide, zinc oxide and magnesium oxide is the technical core of the invention, residual molecular volatile matters after vulcanization are less, a vulcanization crosslinking structure is compact, and the prepared rubber plug has good biocompatibility with the in-vitro diagnostic reagents of the Siemens technology; the preparation method is simple and is suitable for industrial production.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to a chlorinated butyl rubber plug for an in-vitro diagnostic reagent and a preparation method thereof.
Background
Currently, halogenated butyl rubber used in medical packaging is mainly chlorinated butyl rubber and brominated butyl rubber. The chlorinated butyl rubber has the advantages of heat resistance, ozone resistance, chemical corrosion resistance medium resistance, low air permeability and the like, but has relatively low activity, slightly larger selection limitation of a vulcanization system and severe technical requirements of a production process.
The technology of the Siemens' femto requires a chlorinated butyl rubber plug for in-vitro diagnostic reagents, and entrusts the applicant to develop products. According to the chemical characteristics of the in-vitro diagnostic reagent provided by the Siemens technology, the inventor finds that the conventional chlorinated butyl rubber plug of a sulfur-magnesium oxide or phenolic resin-zinc oxide vulcanization system cannot meet the requirement of the in-vitro diagnostic reagent on compatibility.
Disclosure of Invention
The invention aims to overcome the technical defects, and provides a chlorinated butyl rubber plug for an in-vitro diagnostic reagent and a preparation method thereof, which solve the technical problem of poor compatibility between the chlorinated butyl rubber plug and the in-vitro diagnostic reagent in the prior art.
The invention provides a chlorinated butyl rubber plug for an in-vitro diagnostic reagent, which comprises the following raw materials in parts by weight: 100 parts of chlorinated butyl rubber, 60-80 parts of calcined kaolin, 1-3 parts of titanium dioxide, 0.2-0.4 part of carbon black, 4-6 parts of zinc oxide, 0.4-0.8 part of magnesium oxide, 5-7 parts of talcum powder, 4-6 parts of white carbon black and 0.8-1 part of p-tert-amyl phenol disulfide.
The invention also provides a preparation method of the chlorinated butyl rubber plug for the in-vitro diagnostic reagent, which comprises the following steps:
the chlorinated butyl rubber plug for the in-vitro diagnostic reagent is obtained by proportioning according to the proportion and then sequentially carrying out the processes of banburying, open milling, preforming, vulcanizing, punching, cleaning and siliconizing, inner packaging and outer packaging.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, the rubber plug capable of meeting the requirements of the in-vitro diagnostic reagent of the Siemens technology is provided through the formula design, the vulcanization system of p-tert-amyl phenol disulfide, zinc oxide and magnesium oxide is the technical core of the invention, residual molecular volatile matters after vulcanization are less, the vulcanization crosslinking structure is compact, and the prepared rubber plug has good biocompatibility with the in-vitro diagnostic reagent of the Siemens technology; the preparation method is simple and is suitable for industrial production.
Detailed Description
The present invention will be described in further detail with reference to the following examples in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
The invention provides a chlorinated butyl rubber plug for an in-vitro diagnostic reagent, which comprises the following raw materials in parts by weight: 100 parts of chlorinated butyl rubber, 60-80 parts of calcined kaolin, 1-3 parts of titanium dioxide, 0.2-0.4 part of carbon black, 4-6 parts of zinc oxide, 0.4-0.8 part of magnesium oxide, 5-7 parts of talcum powder, 4-6 parts of white carbon black and 0.8-1 part of p-tert-amyl phenol disulfide.
Preferably, the mass ratio of p-tert-amylphenol disulfide to zinc oxide is (0.15 to 0.25): 1, more preferably (0.16 to 0.2): 1.
Preferably, the mass ratio of magnesium oxide to zinc oxide is (0.1 to 0.15): 1, more preferably (0.12 to 0.14): 1.
Preferably, the chlorinated butyl rubber plug for the in vitro diagnostic reagent comprises the following raw materials in parts by weight: 100 parts of chlorinated butyl rubber, 70 parts of calcined kaolin, 2 parts of titanium dioxide, 0.3 part of carbon black, 5 parts of zinc oxide, 0.5 to 0.7 part of magnesium oxide, 5 to 6 parts of talcum powder, 4 to 6 parts of white carbon black and 0.8 to 1 part of p-tert-amylphenol disulfide.
Preferably, the chlorinated butyl rubber plug for the in vitro diagnostic reagent comprises the following raw materials in parts by weight: 100 parts of chlorinated butyl rubber, 70 parts of calcined kaolin, 2 parts of titanium dioxide, 0.3 part of carbon black, 5 parts of zinc oxide, 0.7 part of magnesium oxide, 5 parts of talcum powder, 4 parts of white carbon black and 1 part of p-tertiary amyl phenol disulfide.
Preferably, the chlorinated butyl rubber plug for the in vitro diagnostic reagent comprises the following raw materials in parts by weight: 100 parts of chlorinated butyl rubber, 70 parts of calcined kaolin, 2 parts of titanium dioxide, 0.3 part of carbon black, 5 parts of zinc oxide, 0.5 part of magnesium oxide, 6 parts of talcum powder, 6 parts of white carbon black and 0.8 part of p-tertiary amyl phenol disulfide.
Preferably, the chlorinated butyl rubber plug for the in vitro diagnostic reagent comprises the following raw materials in parts by weight: 100 parts of chlorinated butyl rubber, 70 parts of calcined kaolin, 2 parts of titanium dioxide, 0.3 part of carbon black, 5 parts of zinc oxide, 0.6 part of magnesium oxide, 6 parts of talcum powder, 5 parts of white carbon black and 0.9 part of p-tertiary amyl phenol disulfide.
The invention also provides a preparation method of the chlorinated butyl rubber plug for the in-vitro diagnostic reagent, which comprises the following steps:
the chlorinated butyl rubber plug for the in-vitro diagnostic reagent is obtained by proportioning according to the proportion and then sequentially carrying out the processes of banburying, open milling, preforming, vulcanizing, punching, cleaning and siliconizing, inner packaging and outer packaging.
In the following examples of the present invention, the raw materials are as follows: chlorinated butyl rubber plug CIIR1240, calcined kaolin (inner Mongolian New), titanium dioxide (Nanjtai whitening industry), zinc oxide (Shanghai Beijing chemical industry), magnesium oxide (Shanxi Ganying), carbon black N774 (Xinjiang ya Clar), talcum powder (Gui Lingui Guangdong), white carbon black (Wuxi Heng), p-tert-pentylphenol disulfide V710 (Holland import).
Example 1
The chlorinated butyl rubber plug for the in-vitro diagnostic reagent comprises the following raw materials in parts by weight: 100 parts of chlorinated butyl rubber, 70 parts of calcined kaolin, 2 parts of titanium dioxide, 0.3 part of carbon black, 5 parts of zinc oxide, 0.7 part of magnesium oxide, 5 parts of talcum powder, 4 parts of white carbon black and 1 part of p-tertiary amyl phenol disulfide.
The preparation method of the chlorinated butyl rubber plug for the in-vitro diagnostic reagent comprises the following steps:
the chlorinated butyl rubber plug for the in-vitro diagnostic reagent is obtained by proportioning according to the proportion and then sequentially carrying out the processes of banburying, open milling, preforming, vulcanizing, punching, cleaning and siliconizing, inner packaging and outer packaging.
Example 2
The chlorinated butyl rubber plug for the in-vitro diagnostic reagent comprises the following raw materials in parts by weight: 100 parts of chlorinated butyl rubber, 70 parts of calcined kaolin, 2 parts of titanium dioxide, 0.3 part of carbon black, 5 parts of zinc oxide, 0.5 part of magnesium oxide, 6 parts of talcum powder, 6 parts of white carbon black and 0.8 part of p-tertiary amyl phenol disulfide.
The preparation method of the chlorinated butyl rubber plug for the in-vitro diagnostic reagent comprises the following steps:
the chlorinated butyl rubber plug for the in-vitro diagnostic reagent is obtained by proportioning according to the proportion and then sequentially carrying out the processes of banburying, open milling, preforming, vulcanizing, punching, cleaning and siliconizing, inner packaging and outer packaging.
Example 3
The chlorinated butyl rubber plug for the in-vitro diagnostic reagent comprises the following raw materials in parts by weight: 100 parts of chlorinated butyl rubber, 70 parts of calcined kaolin, 2 parts of titanium dioxide, 0.3 part of carbon black, 5 parts of zinc oxide, 0.6 part of magnesium oxide, 6 parts of talcum powder, 5 parts of white carbon black and 0.9 part of p-tertiary amyl phenol disulfide.
The preparation method of the chlorinated butyl rubber plug for the in-vitro diagnostic reagent comprises the following steps:
the chlorinated butyl rubber plug for the in-vitro diagnostic reagent is obtained by proportioning according to the proportion and then sequentially carrying out the processes of banburying, open milling, preforming, vulcanizing, punching, cleaning and siliconizing, inner packaging and outer packaging.
Comparative example 1
The chlorinated butyl rubber plug for the in-vitro diagnostic reagent comprises the following raw materials in parts by weight: 100 parts of chlorinated butyl rubber, 70 parts of calcined kaolin, 2 parts of titanium dioxide, 0.3 part of carbon black, 5 parts of zinc oxide, 6 parts of talcum powder, 5 parts of white carbon black and 0.9 part of p-tertiary amyl phenol disulfide.
The preparation method of the chlorinated butyl rubber plug for the in-vitro diagnostic reagent comprises the following steps:
the chlorinated butyl rubber plug for the in-vitro diagnostic reagent is obtained by proportioning according to the proportion and then sequentially carrying out the processes of banburying, open milling, preforming, vulcanizing, punching, cleaning and siliconizing, inner packaging and outer packaging.
Comparative example 2
The chlorinated butyl rubber plug for the in-vitro diagnostic reagent comprises the following raw materials in parts by weight: 100 parts of chlorinated butyl rubber, 70 parts of calcined kaolin, 2 parts of titanium dioxide, 0.3 part of carbon black, 4.5 parts of zinc oxide, 1.1 parts of magnesium oxide, 6 parts of talcum powder, 5 parts of white carbon black and 0.9 part of p-tertiary amyl phenol disulfide.
The preparation method of the chlorinated butyl rubber plug for the in-vitro diagnostic reagent comprises the following steps:
the chlorinated butyl rubber plug for the in-vitro diagnostic reagent is obtained by proportioning according to the proportion and then sequentially carrying out the processes of banburying, open milling, preforming, vulcanizing, punching, cleaning and siliconizing, inner packaging and outer packaging.
Comparative example 3
The chlorinated butyl rubber plug for the in-vitro diagnostic reagent comprises the following raw materials in parts by weight: 100 parts of chlorinated butyl rubber, 70 parts of calcined kaolin, 2 parts of titanium dioxide, 0.3 part of carbon black, 5 parts of zinc oxide, 0.6 part of magnesium oxide, 6 parts of talcum powder, 5 parts of white carbon black and 0.6 part of p-tertiary amyl phenol disulfide.
The preparation method of the chlorinated butyl rubber plug for the in-vitro diagnostic reagent comprises the following steps:
the chlorinated butyl rubber plug for the in-vitro diagnostic reagent is obtained by proportioning according to the proportion and then sequentially carrying out the processes of banburying, open milling, preforming, vulcanizing, punching, cleaning and siliconizing, inner packaging and outer packaging.
Comparative example 4
The chlorinated butyl rubber plug for the in-vitro diagnostic reagent comprises the following raw materials in parts by weight: 100 parts of chlorinated butyl rubber, 70 parts of calcined kaolin, 2 parts of titanium dioxide, 0.3 part of carbon black, 5 parts of zinc oxide, 0.6 part of magnesium oxide, 6 parts of talcum powder, 5 parts of white carbon black and 1.3 parts of p-tertiary amyl phenol disulfide.
The preparation method of the chlorinated butyl rubber plug for the in-vitro diagnostic reagent comprises the following steps:
the chlorinated butyl rubber plug for the in-vitro diagnostic reagent is obtained by proportioning according to the proportion and then sequentially carrying out the processes of banburying, open milling, preforming, vulcanizing, punching, cleaning and siliconizing, inner packaging and outer packaging.
Test group
The chlorinated butyl rubber stoppers obtained in examples 1 to 3 and comparative examples 1 to 4 were subjected to performance test, and the results are shown in tables 1 to 2. Wherein, the in vitro diagnostic reagent is provided by the Siemens technology.
TABLE 1
| Compatibility of | |
| Example 1 | Compliance with |
| Example 2 | Compliance with |
| Example 3 | Compliance with |
| Comparative example 1 | Is not in line with |
| Comparative example 2 | Is not in line with |
| Comparative example 3 | Is not in line with |
| Comparative example 4 | Is not in line with |
TABLE 2
| Example 1 | Example 2 | Example 3 | |
| Pyrogens | Compliance with | Compliance with | Compliance with |
| Hemolysis | Compliance with | Compliance with | Compliance with |
| Acute toxicity | Compliance with | Compliance with | Compliance with |
| Clarity and color | Compliance with | Compliance with | Compliance with |
| pH change value | ＜1.0 | ＜1.0 | ＜1.0 |
| Absorbance of ultraviolet light | ＜0.1 | ＜0.1 | ＜0.1 |
| Easily oxidized material | ＜3.0ml | ＜3.0ml | ＜3.0ml |
As can be seen from the tables 1-2, the rubber plug obtained by the formula of the embodiment of the invention has various performances meeting the relevant regulations, which proves that the rubber plug prepared by the embodiment of the invention can well meet the requirements of the in-vitro diagnostic reagent of the Siemens technology.
The above-described embodiments of the present invention do not limit the scope of the present invention. Any other corresponding changes and modifications made in accordance with the technical idea of the present invention shall be included in the scope of the claims of the present invention.
Claims (10)
1. The chlorinated butyl rubber plug for the in-vitro diagnostic reagent is characterized by comprising the following raw materials in parts by weight: 100 parts of chlorinated butyl rubber, 60-80 parts of calcined kaolin, 1-3 parts of titanium dioxide, 0.2-0.4 part of carbon black, 4-6 parts of zinc oxide, 0.4-0.8 part of magnesium oxide, 5-7 parts of talcum powder, 4-6 parts of white carbon black and 0.8-1 part of p-tert-amyl phenol disulfide.
2. The chlorinated butyl rubber stopper for in vitro diagnostic reagent according to claim 1, wherein the mass ratio of p-tert-amylphenol disulfide to zinc oxide is (0.15 to 0.25): 1.
3. The chlorinated butyl rubber stopper for in vitro diagnostic reagent according to claim 1, wherein the mass ratio of p-tert-amylphenol disulfide to zinc oxide is (0.16 to 0.2): 1.
4. The chlorinated butyl rubber stopper for in vitro diagnostic reagent according to claim 1, wherein the mass ratio of magnesium oxide to zinc oxide is (0.1 to 0.15): 1.
5. The chlorinated butyl rubber stopper for in vitro diagnostic reagent according to claim 1, wherein the mass ratio of magnesium oxide to zinc oxide is (0.12 to 0.14): 1.
6. The chlorinated butyl rubber stopper for in vitro diagnostic reagent according to claim 1, wherein the chlorinated butyl rubber stopper for in vitro diagnostic reagent comprises the following raw materials in parts by weight: 100 parts of chlorinated butyl rubber, 70 parts of calcined kaolin, 2 parts of titanium dioxide, 0.3 part of carbon black, 5 parts of zinc oxide, 0.5 to 0.7 part of magnesium oxide, 5 to 6 parts of talcum powder, 4 to 6 parts of white carbon black and 0.8 to 1 part of p-tert-amylphenol disulfide.
7. The chlorinated butyl rubber stopper for in vitro diagnostic reagent according to claim 1, wherein the chlorinated butyl rubber stopper for in vitro diagnostic reagent comprises the following raw materials in parts by weight: 100 parts of chlorinated butyl rubber, 70 parts of calcined kaolin, 2 parts of titanium dioxide, 0.3 part of carbon black, 5 parts of zinc oxide, 0.7 part of magnesium oxide, 5 parts of talcum powder, 4 parts of white carbon black and 1 part of p-tertiary amyl phenol disulfide.
8. The chlorinated butyl rubber stopper for in vitro diagnostic reagent according to claim 1, wherein the chlorinated butyl rubber stopper for in vitro diagnostic reagent comprises the following raw materials in parts by weight: 100 parts of chlorinated butyl rubber, 70 parts of calcined kaolin, 2 parts of titanium dioxide, 0.3 part of carbon black, 5 parts of zinc oxide, 0.5 part of magnesium oxide, 6 parts of talcum powder, 6 parts of white carbon black and 0.8 part of p-tertiary amyl phenol disulfide.
9. The chlorinated butyl rubber stopper for in vitro diagnostic reagent according to claim 1, wherein the chlorinated butyl rubber stopper for in vitro diagnostic reagent comprises the following raw materials in parts by weight: 100 parts of chlorinated butyl rubber, 70 parts of calcined kaolin, 2 parts of titanium dioxide, 0.3 part of carbon black, 5 parts of zinc oxide, 0.6 part of magnesium oxide, 6 parts of talcum powder, 5 parts of white carbon black and 0.9 part of p-tertiary amyl phenol disulfide.
10. A method for preparing a chlorinated butyl rubber stopper for an in vitro diagnostic reagent according to any one of claims 1 to 10, comprising the steps of:
the chlorinated butyl rubber plug for the in-vitro diagnostic reagent is obtained by proportioning according to the proportion and then sequentially carrying out the processes of banburying, open milling, preforming, vulcanizing, punching, cleaning and siliconizing, inner packaging and outer packaging.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202310147832.5A CN116144123A (en) | 2023-02-22 | 2023-02-22 | Chlorinated butyl rubber plug for in-vitro diagnostic reagent and preparation method thereof |
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| CN202310147832.5A CN116144123A (en) | 2023-02-22 | 2023-02-22 | Chlorinated butyl rubber plug for in-vitro diagnostic reagent and preparation method thereof |
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| WO2015136792A1 (en) * | 2014-03-12 | 2015-09-17 | 電気化学工業株式会社 | Rubber composition and vulcanized product thereof |
| CN109679240A (en) * | 2018-12-28 | 2019-04-26 | 江阴市海华橡塑有限公司 | A kind of medicinal chlorinated butyl rubber plug and its production technology |
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2023
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| US3880821A (en) * | 1972-11-24 | 1975-04-29 | Polysar Ltd | Halogenated butyl rubber of improved scorch characteristics |
| WO2007050071A1 (en) * | 2005-10-27 | 2007-05-03 | Exxonmobil Chemical Patents, Inc. | Thermoplastic elastomer composition and process for producing same |
| CN101305046A (en) * | 2005-11-09 | 2008-11-12 | 埃克森美孚化学专利公司 | Thermoplastic elastomer compositions and methods for making the same |
| JP2013047010A (en) * | 2012-10-31 | 2013-03-07 | Yokohama Rubber Co Ltd:The | Laminate of thermoplastic polymer composition having low air permeability and pneumatic tire using same as inner liner |
| WO2015136792A1 (en) * | 2014-03-12 | 2015-09-17 | 電気化学工業株式会社 | Rubber composition and vulcanized product thereof |
| CN109679240A (en) * | 2018-12-28 | 2019-04-26 | 江阴市海华橡塑有限公司 | A kind of medicinal chlorinated butyl rubber plug and its production technology |
| CN111019254A (en) * | 2019-12-23 | 2020-04-17 | 山东省药用玻璃股份有限公司 | Brominated butyl rubber plug for alkali-resistant medicine and preparation method thereof |
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