CN116136534A

CN116136534A - Sample analysis device and detection method

Info

Publication number: CN116136534A
Application number: CN202111358181.1A
Authority: CN
Inventors: 甘泉; 钟勇锋; 张奇奇
Original assignee: Edan Instruments Inc
Current assignee: Edan Instruments Inc
Priority date: 2021-11-16
Filing date: 2021-11-16
Publication date: 2023-05-19

Abstract

The application provides a sample analysis device and a protein detection method, wherein the sample analysis device comprises a shell and a protein detection device. The protein detection apparatus is provided in the housing, including: the protein reaction mechanism comprises at least two protein reactors, and is provided with a detection channel for detecting a sample to be detected in the detection channel; the protein detection mechanism can detect samples to be detected in the at least two protein reactors in sequence. The at least two protein reactors can move relative to the protein detection mechanism, so that one protein detection mechanism can detect a plurality of protein reactors, and the detection result is more accurate.

Description

Sample analysis device and detection method

Technical Field

The present disclosure relates to the field of blood testing, and in particular, to a sample analysis device and a testing method.

Background

Blood tests generally include blood routine tests and Protein tests, such as blood routine +C-Reactive Protein (CRP), blood routine +serum amyloid A (SAA), blood routine +CRP +SAA, or even more parameters, such as Procalcitonin (PCT), IL6, and the like.

Different reagents are needed for different protein detection, and the different reagents cannot be mixed, in the existing integrated machine for blood routine and multiple protein combined detection, different protein detection mechanisms are usually arranged for different protein reactors, that is to say, the same sample is detected in different detection channels, so that relative deviation exists, and therefore, the consistency of multi-channel measurement is difficult to ensure by adopting a multi-channel detection technology. And the cost of multiple protein detection mechanisms can be relatively high. In general, in order to increase the speed of parameter measurement, more detection devices need to be configured, which undoubtedly increases the cost of the instrument.

Disclosure of Invention

One aspect of the present application provides a sample analysis apparatus for testing a blood sample to obtain a test parameter. The sample analysis device includes a housing and a protein detection apparatus. The protein detection apparatus is disposed within the housing, comprising: the device comprises a protein reaction mechanism and a protein detection mechanism, wherein the protein reaction mechanism comprises at least two protein reactors, and is provided with a detection channel for detecting a sample to be detected in the detection channel; the at least two protein reactors and the protein detection mechanism can perform relative movement, so that the at least two protein reactors sequentially enter the detection channel, and the protein detection mechanism sequentially detects samples to be detected in the at least two protein reactors.

In yet another aspect, the present application provides a sample detection method applied to a sample analysis device. The sample analysis equipment comprises a shell and a specific protein detection device, wherein the specific protein detection device is arranged in the body, the specific protein detection device comprises a protein reaction mechanism and a protein detection mechanism, the protein reaction mechanism comprises at least two protein reactors, the at least two protein reactors are used for bearing samples to be detected, and the protein detection mechanism is provided with a detection channel. The protein detection method comprises the following steps: the at least two protein reactors and the protein detection mechanism perform relative movement, so that the at least two protein reactors sequentially enter the detection channel; the protein detection mechanism sequentially detects the sample to be detected in the corresponding protein reactor entering the detection channel so as to obtain protein parameters.

The application provides a sample analysis device, wherein protein reaction mechanism set up in on the protein detection mechanism, including at least two protein reactors, at least two protein reactors can with the protein detection mechanism takes place relative motion, makes at least two protein reactors be located in the detection passageway of protein detection mechanism. Therefore, one protein detection mechanism can detect a plurality of protein reactors to obtain a plurality of protein detection parameters, and the detection result is more accurate because only one protein detection mechanism can reduce the systematic error caused by the detection of a plurality of protein detection mechanisms. In addition, the application only sets up a protein detection mechanism, can reduce the cost of sample analysis equipment.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings that are required to be used in the embodiments will be briefly described below. It is apparent that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained from these drawings without inventive effort for a person of ordinary skill in the art.

FIG. 1 is a block diagram of a sample analysis device according to one embodiment of the present application;

FIG. 2 is a schematic perspective view of the sample analyzer shown in FIG. 1;

FIG. 3 is a schematic perspective view of a portion of the sample analyzer shown in FIG. 1;

FIG. 4 is a schematic diagram showing the structure of the blood conventional reactor in FIG. 1;

FIG. 5 is a schematic diagram showing a three-dimensional structure of the protein detection apparatus in FIG. 1;

FIG. 6 is a schematic diagram showing the three-dimensional structure of the protein reaction mechanism in FIG. 5;

FIG. 7 discloses an exploded view of the protein reaction mechanism of FIG. 6;

FIG. 8 is a schematic perspective view of the base of FIG. 9;

FIG. 9 is a schematic diagram showing the relative linear motion of at least two protein reactors and a protein detection mechanism;

FIG. 10 is a schematic diagram showing the relative circular motion of at least two protein reactors and a protein detection mechanism;

FIG. 11 is a schematic diagram showing a perspective structure of the protein detection mechanism in FIG. 5;

FIG. 12 discloses an exploded view of the protein detection mechanism of FIG. 11;

FIG. 13 is a schematic perspective view of the main body of FIG. 12;

FIG. 14 discloses a schematic structural view of the mounting bracket of FIG. 5;

FIG. 15 is a schematic view of the support body of FIG. 5;

FIG. 16 is a schematic diagram showing the structure of the sample collection and distribution device of FIG. 1;

FIG. 17 is a schematic diagram showing a structure of the protein reagent supplying apparatus of FIG. 1;

FIG. 18 is a flow chart of a method for testing a blood sample according to an embodiment of the present application;

FIG. 19 discloses a flowchart of step S102 in FIG. 18;

FIG. 20 is a flowchart of step S103 in FIG. 18;

fig. 21 discloses a flowchart of step S104 in fig. 18.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. It will be apparent that the described embodiments are only some, but not all, of the embodiments of the present application. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the present disclosure.

Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment may be included in at least one embodiment of the present application. The appearances of such phrases in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. Those of skill in the art will explicitly and implicitly appreciate that the embodiments described herein may be combined with other embodiments.

It should be noted that the terms "first," "second," and the like herein are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more of the described features.

In this context, the orientations of "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "upper", "lower" may be used. It is to be understood that the terms "center," "longitudinal," "transverse," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like, herein refer to an orientation or positional relationship based on that shown in the drawings, merely for convenience of description and to simplify the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be configured and operated in a particular orientation, and therefore are not to be construed as limiting of the present application.

The terms "disposed on," "connected to," "mounted to," and the like herein may refer to two elements or objects, such as a and B, being in direct contact with "disposed," "connected," "mounted," and the like, as well as to two elements or objects being in indirect contact with "disposed," "connected," "mounted," and the like, via another element or object, such as C, and the like.

Next, a sample analysis device using a blood detection technique is described. The blood detection technology is a detection technology for obtaining blood routine detection parameters and protein detection parameters after the blood routine reaction reagent and the specific protein reaction reagent react with a sample to be detected, and provides information and decision basis for disease prediction, diagnosis, prevention, treatment and prognosis.

Monolithic structure-sample analysis device 100

Referring to fig. 1-3, fig. 1 discloses a block diagram of a sample analysis device 100 according to an embodiment of the present application, fig. 2 discloses a schematic perspective view of the sample analysis device 100 in fig. 1, and fig. 3 discloses a schematic perspective view of a part of the structure of the sample analysis device 100 in fig. 1. The sample analysis apparatus 100 may include a housing 10, a blood routine testing device 20, a protein testing device 30, a sample collection and dispensing device 40, a reagent supply device 50, a drive device 60, and a control system 70. The blood routine detecting device 20, the protein detecting device 30, the sample collecting and dispensing device 40, the reagent supplying device 50, the driving device 60 and the control system 70 are all arranged on the casing 10 and are located in the casing 10.

The blood routine testing device 20 is used for performing blood routine testing on a blood sample. The sample collection and distribution device 40 is used for collecting and transporting the blood sample and distributing the collected blood sample to the blood routine testing device 20 and/or the protein testing device 30 in a desired amount. The reagent supplying apparatus 50 is used to supply various reagents to be mixed with the blood sample and dispense the corresponding reagents to the blood routine detecting apparatus and/or the protein detecting apparatus 30. The control system 70 may be used to control the sample collection and distribution device 40 to collect and distribute blood samples, to control the reagent supply device 50 to supply corresponding reagents to the blood routine testing device 20 and/or the protein testing device 30, and to control the protein testing device 30 to test the blood samples and obtain protein testing parameters based on the testing signals. The control system may also control the blood routine testing device 20 to test the blood sample and obtain blood routine parameters based on the test signals.

Additionally, in some embodiments, the sample analysis apparatus 100 may further include a sample introduction mechanism 80 mounted on the housing 10 and located outside the housing 10 for providing a blood sample to the blood routine testing device 20 and/or the protein testing device 30.

In addition, in some embodiments, the sample analysis apparatus 100 may further include a waste liquid collecting device 90 mounted on the housing 10 for collecting waste liquid generated during or after the detection, such as blood sample reaction liquid, surplus reagent, and the like.

Additionally, in some embodiments, the sample analysis device 100 may further include a display and/or a keyboard or the like that may be electrically connected to the control system 70 to input control instructions to the sample analysis device 100, e.g., the control system 70, via the input device, to enable the sample analysis device 100 to perform routine blood testing and control of at least one specific protein test on the blood sample via the control system 70, e.g., to enable a user to select a corresponding test mode, e.g., routine blood testing mode, protein testing mode (including CRP, SAA, PCT, IL6, etc.), via the display, to enable the sample analysis device 100 to perform a corresponding test.

Additionally, in some embodiments, the sample analysis device 100 may further include an output device such as a display, printer, etc. that may be electrically connected to the control system 70 to output the detected parameters of the sample analysis device 100 via the output device. Of course, a memory storing the detection parameters may also be provided within the sample analysis device 100.

In some embodiments, the sample analysis apparatus 100 may further include a power supply system for providing power to the blood routine testing device 20, the protein testing device 30, the sample collection and distribution device 40, the reagent supply device 50, the control system 70, and the like.

Housing 10

Referring to fig. 2-3, the housing 10 may be integrally formed of a rigid material such as plastic, metal, etc. The housing 10 may include a housing base 11 and a housing sidewall 12 connected to the housing base 11. The housing base 11 and the housing side wall 12 may be integrally formed or detachable, and may be connected by one of screwing, fastening, welding, bonding, plugging, etc. The housing base 11 and the housing side wall 12 may have plate-like structures, but may have other shapes, and details thereof are omitted. Wherein, the blood routine detecting device 20, the protein detecting device 30, the sample collecting and dispensing device 40, the reagent supplying device 50, etc. are all mounted on the housing base 11. Specifically, the housing base 11 may include a first surface 110, and the blood routine testing device 20, the protein testing device 30, the sample collection and distribution device 40, and the reagent supplying device 50 may be disposed on the first surface 110 at intervals. The sample acquisition and distribution device 40, sample introduction mechanism 80, and control system 70 may be mounted to the housing sidewall 12.

In some embodiments, the housing 10 may further include a housing top plate 13 connected to the housing base 11 and the housing side wall 12 to form a closed housing 10 with the housing base 11 and the housing side wall 12. The housing 10 may define a containing space surrounded by the housing base 11, the housing side wall 12 and the housing top plate 13, where the containing space may accommodate the blood routine detecting device 20, the protein detecting device 30, the sample collecting and distributing device 40, the reagent supplying device 50, the control system 70, etc. to protect the internal structure of the sample analyzing apparatus 100, and also reduce the interference of external factors (such as ambient light) to the detecting process. The top plate 13 of the housing may have a plate-like structure, but may have other shapes, and will not be described in detail.

Blood routine detection device 20

Referring to fig. 1 and 4, the blood routine testing device 20 includes at least one blood routine reactor 21 and a blood routine testing mechanism 22 disposed on a housing 10, such as a housing base 11. At least one blood conventional reactor 21 can be used for providing a reaction place for a sample to be tested, can be repeatedly used and saves materials. In performing routine blood tests, a blood sample and corresponding reagents may be added to at least one routine blood reactor 21. When a large number of samples to be detected are needed to be detected, the samples to be detected can be added into the plurality of blood conventional reactors 21, so that the detection efficiency is improved. In some embodiments, each blood conventional reactor 21 has a first injection port 210 for injecting a sample, and the first injection port 210 may be opened on top of the blood conventional reactor 21 to facilitate receiving a sample to be measured. The side wall of each blood conventional reactor 21 may be provided with at least one first connection port 211, for example, the side wall of the blood conventional reactor 21 in fig. 4 is provided with two connection ports 211. The first connection port 211 may be used to communicate the blood conventional reactor 21 with the reagent supply 50 via a line to obtain at least one reagent or wash fluid (e.g., a hemolyzing agent or latex reagent or diluent). A first liquid outlet 212 may be provided at the bottom of each blood conventional reactor 21 for discharging waste liquid.

The blood routine detection mechanism 22 may be electrically connected to the control system 70 to perform blood routine measurements on the blood sample reaction fluid added to the at least one blood routine reactor 21 under the control of the control system 70 to obtain the at least one blood routine parameter. The blood routine parameters may include at least one or more combinations of WBC (White blood cell) five classification results, WBC count and morphology parameters, HGB (Hemoglobin) functional measurements, RBC (Red blood cell) and PLT (platelet) count and morphology parameters, and the blood routine test items may be increased or decreased as needed during the actual blood routine test. The blood routine detection mechanism 22 may be an optical detection mechanism or an impedance detection mechanism.

Protein detection apparatus 30

The protein detection device 30 may be disposed in the housing 10 at a distance from the blood routine detection device 20, and disposed on the same side of the sample collection and distribution device 40, to provide samples to be tested for the protein detection device 30 and the blood routine detection device 20, respectively. Referring also to fig. 5, the protein detection apparatus 30 may include a protein reaction mechanism 31 disposed on the housing 10 and a protein detection mechanism 32 connected to the protein reaction mechanism 31. The protein reaction mechanism 31 is used for carrying a sample to be tested, and in some embodiments, provides a reaction site for the sample to be tested and the reagent. The protein reaction mechanism 32 is provided with a detection channel for detecting a sample to be detected in the protein reaction mechanism 31.

Referring also to fig. 6-8, in some embodiments, the protein reaction mechanism 31 includes a base 311 disposed on the protein detection mechanism 32, a reactor mounting assembly 314 coupled to the drive 60, at least two protein reactors 315 mounted on the reactor mounting assembly 314, and a target position detector 318 mounted on the base 311.

Wherein the base 311 includes a base plate 3111 mounted on the protein detection mechanism 32 and a side plate 3112 connected to the base plate 3111. The base plate 3111 and the side plate 3112 may be of an integrated structure or of a detachable structure, and are not particularly limited herein.

In some embodiments, the substrate 3111 is disposed on a side of the protein detection mechanism 32 remote from the housing base 11. The base plate 3111 may be provided with mounting holes 31110. The substrate 3111 may be made of a rigid material such as plastic, metal, or the like. The substrate 3111 may have a plate-like structure, but may have other shapes, and will not be described in detail.

The side plate 3112 extends toward a side away from the protein detection mechanism 32 with respect to the base plate 3111. The side plates 3112 may be made of a rigid material such as plastic, metal, or the like. The side plate 3112 may include a side plate body 31121 and a side plate edge 31122 connected to the side plate body 31121, the side plate edge 31122 surrounding the side plate body 31121. The side plate body 31121 may be provided with mounting holes 31123. The side panel edge 31122 can cooperate with the side panel body 31121 and other panel bodies to form a receiving cavity to protect the target position detector 318 and the like located within the receiving cavity.

The reactor mounting assembly 314 is used to mount at least two protein reactors. The reactor mounting assembly 314 may include a mount 3141 mounted to the drive 60 and a carrier 3142 mounted to the mount 3141.

The fixing member 3141 includes a fixing member main body 3141a and a crimping member 3141b connected to the driving device 60.

The holder body 3141a may have a Z-type structure. One end of the fixing member body 3141a and the pressing member 3141b may be connected and fixed to the timing belt by screwing, inserting, fastening, welding, bonding, or the like. In some embodiments, the fastener body 3141a may be made of a rigid material such as plastic, metal, etc., and is not particularly limited herein.

The bearing mechanism 3142 is mounted on the mount body 3141a, specifically, may be mounted on the other end of the mount body 3141 a. The bearing 3142 may be made of a rigid material such as plastic, metal, etc. The bearing mechanism 3142 may have a plate-like structure, but may also have other shapes, which will not be described in detail. The carrier 3142 may be provided with at least two openings 3142a such that each protein reactor 315 is mounted to the carrier 3142 through a respective opening 3142 a. At least two openings 3142a are in one-to-one correspondence with at least two protein reactors 315.

At least two protein reactors 315 are configured to carry a sample to be tested and are movable, e.g., in a linear or circular motion, relative to the protein detection mechanism 32. In some embodiments, at least two protein reactors 315 may be configured to be stationary relative to housing base 11 and protein detection mechanism 21 may be configured to be movable relative to housing base 11. In other embodiments, the protein detection mechanism 32 may be configured to be stationary relative to the housing base 11 and the at least two protein reactors 315 may be configured to be movable relative to the housing base 11. In other embodiments, both the protein detection mechanism 32 and the at least two protein reactors 315 may be configured to be movable relative to the housing base 11.

At least two protein reactors 315 may be connected to the drive 60 via a reactor mounting assembly 314. The drive 60 moves at least two protein reactors 315 by driving the reactor mounting assembly 314.

Specifically, in some embodiments, protein reactor 315 includes a support 3151 disposed on reactor mounting assembly 314 and a reactor body 3152 coupled to an opening of support 3151. The support portion 3151 extends from the connection with the reactor body 3152 in a direction away from the reactor body 3152, so that the support portion 3151 and the reactor body 3152 may form a T-shaped structure. The reactor body 3152 and the support portion 3151 may be mounted on the bearing mechanism 3142 through the opening 3142a in cooperation.

In some embodiments, the protein reactor 315 has a second injection port 3150 for injecting a sample and a reagent to be tested, and the at least one second injection port 3150 and the at least one first injection port 210 may be in line. At least one second connection port 3153 is formed on the side wall of the protein reactor 315, the second connection port 3153 may be used to enable the protein reactor 315 to be communicated with a reagent supply system through a pipeline so as to obtain at least one reaction reagent or cleaning solution (such as a hemolysis agent or a latex reagent or a diluent), and a second liquid outlet 3154 may be formed on the bottom of the protein reactor 315 so as to drain the waste liquid.

In some embodiments, at least two protein reactors 315 may perform different specific protein tests and may also perform the same specific protein test, so in this embodiment, different protein test parameters may be obtained simultaneously by one blood sample according to needs, or the same plurality of protein test parameters may be obtained, which is simple and convenient to operate, and the same specific protein test or different specific protein tests may be performed simultaneously on different blood samples, i.e. the present application may implement simultaneous measurement of specific protein tests of a plurality of samples by one blood sample tester, thereby improving test efficiency. In some embodiments, the number of protein reactors 315 may be 2, 3, 4, 5, 6, or 7, etc., and is not particularly limited herein and may be set as desired.

The target position detector 318 may be mounted to the base 311 by screwing, plugging, snapping, welding, bonding, or the like. In some embodiments, the target position detector 318 may be mounted to the side plate 3112 of the base 311 through mounting holes 31123. The target position detector 318 may be used to detect the position of the protein reactor 315, in particular, to determine whether the protein reactor 315 is located in a detection channel. In other embodiments, the target position detector 318 may be a sensor such as a photoelectric sensor or a mechanical switch such as a micro switch, etc., without limitation.

The protein detection mechanism 32 is disposed on the housing base 11, and the protein detection mechanism 32 is provided with a detection channel for detecting a sample to be detected located in the detection channel. The protein detection mechanism 32 is electrically connected to the control system 70, and can detect the blood sample reaction liquid in the protein reactor 15 under the control of the control system 70 to obtain at least one protein parameter, such as a CRP detection parameter, a SAA detection parameter, a PCT detection parameter, an IL6 detection parameter, and the like.

Referring also to fig. 11-13, the protein detection mechanism 32 may include a body 323, an optical emitter 324, and an optical receiver 325. Wherein an optical emitter 324 is disposed on the body 323 and located at one side of the body 323 for emitting an optical signal. The optical receiver 325 is disposed on the main body 323 and is disposed at the other side of the main body 323 and spaced apart from the optical transmitter 324, for receiving the optical signal emitted from the optical transmitter 324.

The body 323 is formed with a groove 3230, and the groove 3230 can house at least two protein reactors 315. At least two protein reactors 315 are movable within the channel relative to the protein detection mechanism 32. In particular, at least two protein reactors 315 may be guided along a channel 3230 by a drive 60. A portion of the groove 3230 may serve as a detection channel.

The direction of extension of the groove 3230 coincides with the direction of movement of the at least two protein reactors 315 relative to the protein detection mechanism 32, and may be linear or curved, and specifically may be designed as desired. It is understood that the groove 3230 may be linear or circular, and when the groove 3230 is linear, the at least two protein reactors 315 may move linearly along the groove 3230, and when the groove 3230 is circular, the at least two protein reactors 315 may move circularly along the groove 3230.

In some embodiments, the main body 323 includes a first mounting body 3231, a second mounting body 3232 disposed at a distance from the first mounting body 3231, and a connection portion 3233 connected between the first mounting body 3231 and the second mounting body 3232. The first mounting body 3231, the second mounting body 3232 and the connecting portion 3233 can form an integrally formed structure.

The first mounting body 3231 is provided with first light transmission holes 32310 in an arrangement direction of the first and second mounting

bodies

3231 and 3232, and the first light transmission holes 32310 correspond to the optical emitters 324, and can be used to pass optical signals emitted from the optical emitters 324 and reach the protein reactor 315 in the groove 3230.

The second mounting body 3232 is provided with second light transmission holes 32320 in an arrangement direction of the first mounting body 3231 and the second mounting body 3232. The second light transmitting hole 32320 corresponds to the optical receiver 325, and is operable to transmit the optical signal emitted from the optical emitter 324 therethrough and to enable the transmitted optical signal to be received by the optical receiver 325.

In some embodiments, a second bar-shaped hole 32330 can be provided in the middle of the connecting portion 3233 to yield at least two protein reactors 315. The second strip aperture 32330 can cooperate with at least two protein reactors 315 such that at least two protein reactors 315 extend into the second strip aperture 32330, and at least two protein reactors 315 can be moved within the second strip aperture 32330. In some embodiments, the second strip-shaped aperture 32330 extends in a direction consistent with the direction of movement of the at least two protein reactors 315 relative to the protein detection mechanism 32, and may be linear or curvilinear. In some embodiments, the second strip aperture 32330 may also be omitted in cases where the connection 3233 does not require the provision of the second strip aperture 32330 to yield at least two protein reactors 315. Of course, in some embodiments, the connecting portion 3233 may be provided with a second bar-shaped hole 32330, or may be provided with other shaped holes or grooves similar to the second bar-shaped hole 32330, in order to perform some function, such as saving material, reducing weight, etc.

In some embodiments, the base 311 may be disposed on the main body 323, specifically, the base plate 3111 is mounted on the first mounting body 3231, and the side plate 3112 extends away from the first mounting body 3231 relative to the base plate 3111.

The optical emitter 324 is disposed on one side of the groove 3230. In some embodiments, the optical emitter 324 may be mounted on a side of the first mounting body 3231 away from the second mounting body 3232 by one of screwing, buckling, welding, bonding, plugging, and the like, and corresponds to the first light holes 32310. The optical transmitter 324 may be electrically connected to the control system 70 and may transmit optical signals under the control of the control system 70. The optical signal emitted from the optical emitter 324 passes through the first light holes 32310, the grooves and the second light holes 32320 and then enters the optical receiver 325 to be received. In some embodiments of the present application, optical emitter 324 may be a laser emitter for emitting laser light.

The optical receiver 325 is disposed on the other side of the groove 3230. In some embodiments, the optical receiver 325 may be mounted on a side of the second mounting body 3232 away from the first mounting body 3231 by one of screwing, buckling, welding, bonding, plugging, and the like, and corresponds to the second light transmitting hole 32320. The optical receiver 325 may be electrically connected to the control system 70 to transmit a received optical signal, such as light intensity, to the control system 70. The control system 70 converts the received optical signal into a concentration signal to obtain a corresponding protein detection parameter. The optical receiver 325 and the optical transmitter 324 may form the detection channel described above, which refers to a transmission path of an optical signal from the optical transmitter 324 to the optical receiver 325.

In some embodiments, referring to fig. 5 and 13-14, protein detection apparatus 30 may also be mounted within housing 10 by mounting brackets 33 and supports 34.

In some embodiments, the mounting bracket 33 may include a first bracket 331 mounted on the housing 10, a second bracket 332 connected to a side of the first bracket 331, and a third bracket 333 connected to a side of the first bracket 331 and spaced apart from the second bracket 332. The second bracket 332 and the third bracket 333 may respectively form an L-shaped structure with the first bracket 331 for being mounted to the fixed support 34.

In some embodiments, the support 34 may be mounted to the mounting bracket 33 by a second bracket 332 and a third bracket 333. Specifically, the support 34 may be mounted to the second bracket 332 and the third bracket 333 at a side remote from the first bracket 331. The support 34 may be made of a rigid material such as plastic, metal, etc. The supporting body 34 may have a plate-like structure, but may have other shapes, which will not be described in detail. The middle portion of the support 34 may be provided with a first strip-shaped hole 340 to allow for the indexing of at least two protein reactors 315. The first strip-shaped aperture 340 may cooperate with at least two protein reactors 315 such that at least two protein reactors 315 extend into the first strip-shaped aperture 340, or such that at least two protein reactors 315 slide within the first strip-shaped aperture 340. In some embodiments, the first strip-shaped hole 340 extends in a direction consistent with the sliding direction of the at least two protein reactors 315 relative to the protein detection mechanism 32, and may be straight or curved. In some embodiments, the first strip-shaped holes 340 may also be omitted in cases where the support 34 does not need to be provided with the first strip-shaped holes 340 to yield at least two protein reactors 315. Of course, in some embodiments, the support 34 may be provided with a first bar-shaped hole 340, or may be provided with other shaped holes or grooves similar to the first bar-shaped hole 340, in order to perform some function, such as saving material, reducing weight, etc.

Wherein, the first mounting body 3231, the second mounting body 3232 and the connecting portion 3233 are disposed on a side of the supporting body 34 away from the mounting bracket 33. Specifically, the connection portion 3233 may be mounted on a side of the support 34 away from the mounting bracket 33 by a connection structure such as a bolt, a screw, a plug structure, or a buckle structure. Of course, the connection portion 3233 may be attached to the side of the support 34 away from the mounting bracket 33 by welding, bonding, or the like. Further, in this embodiment, the side plate 3112 extends toward a side away from the first attachment body 3231 with respect to the base plate 3111. The protein detecting mechanism 32 is provided on the support 34 and is fixed to the housing 10 by a mounting bracket 33

In addition, in some embodiments, the protein detection apparatus 30 further includes a housing assembly disposed on the protein reaction mechanism for protecting the protein reaction mechanism 31 and the protein detection mechanism 32, and also reducing interference of external factors to the detection process. The housing assembly may be made of a rigid material such as plastic, metal, etc.

When the protein detection apparatus 30 performs protein detection on a sample to be detected, the sample to be detected may be added to the protein reactor 315, and a reaction reagent may be added through the second connection port 3153; then, the driving device 60 drives at least two protein reactors 315 to perform relative motion relative to the protein detection mechanism 32, so that the corresponding protein reactors 315 are positioned in the detection channel; the optical signal emitted by the optical emitter passes through the protein reactor 315 positioned in the groove after passing through the first light hole; the optical signal passes through the protein reactor 315 and then passes through the second light hole, and is received by the optical receiver, the optical receiver sends the received optical signal to the control system, and the control system calculates the corresponding protein parameter according to the received optical signal.

Sample acquiring and dispensing device 40

The sample collection and distribution device is movably connected to the shell and is used for collecting and distributing the sample to be tested. In some embodiments, the sample collection and distribution device 40 may be coupled to the control system 70 and may be used to collect and distribute a sample to be tested to the at least one blood conventional reactor 21 of the blood conventional detection device 20 and the at least two protein reactors 315 of the protein detection device 30 described above. The sample collection and distribution device 40 is disposed on the same side of the blood routine testing device 20 and the protein testing device 30, and conveniently provides a sample to be tested to at least one blood routine reactor 21 and at least two protein reactors 315 of the protein testing device 30. In some embodiments, the path of movement of the sample acquisition and distribution device 40 is a straight line, and the blood routine testing device 20, the reagent supply device 50, and the protein testing device 30 are distributed along the path of movement of the sample acquisition and distribution device.

Referring to fig. 16, in some embodiments, the sample collection and distribution device 40 may include a fixed bracket (not shown) disposed in the housing 10, a first moving mechanism 41 mounted on the fixed bracket, a second moving mechanism 42 mounted on the first moving mechanism 41, and a sample needle 43 mounted in the second moving mechanism 42.

The fixing bracket is used to mount and fix the first moving mechanism 41, the second moving mechanism 42 and the sample needle on the housing base 11, i.e., the first moving mechanism 41, the second moving mechanism 42 and the sample needle 43 may be mounted on the housing base 11 through the fixing bracket.

In some embodiments, the first moving mechanism 42 is configured to move the sample needle 43 in a horizontal direction, which is a direction parallel to the first surface 110 of the housing base 11, such as an X-direction or a Y-direction. The first movement mechanism is electrically connected to the control system 70, and in a set measurement mode, the control system 70 can control the first movement mechanism 41 to drive the sample needle 43 to move in the horizontal direction so that the sample needle 43 is located at the sample sucking position above the test tube, the blood conventional reactor 21 or the second injection port 3150 above the at least one protein reactor 315. The first moving mechanism 41 may include a second guide rail disposed on the housing 10 in a horizontal direction, a second slider disposed on a side of the second guide rail away from the fixed bracket and slidably connected to the second guide rail, a second driving member disposed on a side of the fixed bracket away from the protein detecting device 30, and a second synchronization assembly disposed on the fixed bracket. The second guide rail may be used to cooperate with the second slider to support and guide the reciprocating motion in a given direction relative to the protein detection apparatus 30 by a second moving mechanism 42 mounted on the first moving mechanism 41. The second drive member may be adapted to be electrically connected to the control system 70 and may be movable under the control of the control system 70. The second synchronizing assembly is connected to the second driving member, and is used for installing the second moving mechanism 42, and can be driven by the second driving member to drive the second moving mechanism 42 installed on the second synchronizing assembly to slide reciprocally along the extending direction of the second guide rail, so that the sample needle 43 is located at the sample sucking position, or at the sample dispensing position above the second injection port 3150 of the protein reactor 315 or the first injection port 210 of the blood routine reactor 21. The specific structure and operation principle of the first moving mechanism 41 may refer to the driving device 60 described above, and will not be described herein.

In some embodiments, the second movement mechanism 42 is used to move the sample needle 43 in a vertical direction, which refers to a direction perpendicular to the first surface 110 of the housing base 11, such as the Z-direction. The second movement mechanism 42 is electrically connected to the control system 70, and in the set measurement mode, the control system 70 can control the second movement mechanism 42 to drive the sample needle 43 to move in the vertical direction. The second moving mechanism 42 may include a movable support 421 disposed on a side of the second guide rail away from the fixed support through a second slider, a transmission mechanism 423 disposed on the movable support 421, and a third guide rail 422 disposed on the movable support 421 and connected to the transmission mechanism 423. Wherein the movable support 421 is slidable on the second guide rail by the second driving member and the second synchronizing assembly so that the sample needle 43 mounted on the second moving mechanism 42 can move in a horizontal direction, for example, in the X-direction. The drive mechanism 423 is electrically connected to the control system 70 and is operable to drive the sample needle 43 in a vertical direction, e.g. in the Z-direction, under control of the control system 70. The third guide rail 422 has an extension direction perpendicular to the extension direction of the second guide rail, and can be used to guide the sample needle 43 to perform a reciprocating linear motion in a vertical direction, for example, in the Z direction, so that the sample needle 43 can collect a sample to be measured.

In some embodiments, the sample needle 43 is disposed on the third guide rail 422 and can move relative to the movable rack 421 in a vertical direction under the action of the driving mechanism 423. The sample needle 43 may be introduced into the blood conventional reactor 21 or the at least one protein reactor 315 for collecting the sample to be measured in a test tube, and the sample to be measured in the sample needle 43 is distributed into the blood conventional reactor 21 or the at least one protein reactor 315.

In some embodiments, the sample acquisition and dispensing device 40 may further include a sample needle swab 44 disposed around the sample needle 43, the sample needle swab 44 being operable to clean the outer wall of the sample needle 43, the sample needle swab 44 providing liquid through a liquid path support module (not shown) to clean the outer wall of the sample needle while the cleaned liquid is pumped away when the sample needle 43 is in motion. In the embodiment of the present application, the liquid path support module is used to provide liquid path support for the sample analysis device 100, so as to be able to provide liquid required for sample processing and detection. Specifically, after the sample is collected, a small amount of sample is inevitably adhered to the outside of the sample needle 43, and when the sample needle 43 is driven to rise by the second moving mechanism 42, the swab cleans the outer wall of the sample needle, so that quantitative influence of the outer wall sample is avoided.

Specifically, in some embodiments, the workflow of the sample acquisition and distribution device 40 is: the second driver may drive the second synchronizing assembly under the control of the control system 70; under the action of the second synchronizing assembly, the movable bracket 421 can move along the second guide rail in the horizontal direction to a direction approaching to the test tube through the second sliding block, so that the sample needle 43 positioned on the movable bracket 421 moves to the sample sucking position; the transmission mechanism 423 drives the sample needle 43 to move along the third guide rail 422 to the test tube in the direction close to the test tube in the vertical direction to the sample sucking position, and the sample needle 43 can suck a preset amount of sample to be stored in the sample needle 43 through the power provided by the liquid path support module, so that the sample collecting action is completed; the driving mechanism 423 drives the sample needle 43 to move along the third guide rail 422 in a direction away from the test tube in a vertical direction, so that the sample needle 43 positioned on the movable bracket 421 moves to a sample sucking position; the second driving piece can drive the second synchronous component to move; under the action of the second synchronizing assembly, the movable support 421 can move along the second guide rail in a direction away from the test tube by the second slider, so that the sample needle 43 on the movable support 421 can move to a sample dispensing position above the first injection port 210 of the blood conventional reactor 21 or the second injection ports 3150 of the at least two protein reactors 315; the driving mechanism 423 drives the sample needle 43 to approach the corresponding blood conventional reactor 21 or at least two protein reactors 315 along the third guide rail 422 in the vertical direction, and when the needle tip of the sample needle 43 reaches the corresponding blood conventional reactor 21 or at least two protein reactors 315, the liquid path support module provides power to quantitatively push out the sample stored in the sample needle 43, and the sample is added into the blood conventional reactor 21 or at least two protein reactors 315 to complete the sample distribution action.

It should be noted that, the horizontal moving direction may be any direction parallel to the first surface of the housing base 11, for example, may be an X direction, a Y direction, or both the X direction and the Y direction, for example, by adding a transmission rail in both the X direction and the Y direction, and adding a Y direction transmission device, the moving mechanism (such as the movable bracket 134) can move in the X direction and the Y direction; for another example, the X-direction transmission may be replaced by a rotation device that rotates in a horizontal plane.

Reagent supplying apparatus 50

Referring to fig. 17, the reagent supplying apparatus 50 includes a blood conventional reagent supplying apparatus 51 provided on the housing base 11 and a protein reagent supplying apparatus 52 provided on the housing base 11. The reagent supplying apparatus 50 may be disposed between the blood routine detecting apparatus 20 and the protein detecting apparatus 30 so as to supply the detecting reagent to the blood routine detecting apparatus 20 and the protein detecting apparatus 30. The blood routine reagent supply device 51 is electrically connected to the control system 70 for supplying various reagents for performing blood routine tests to the at least one blood routine reactor 32 in the blood routine test apparatus 20 under the influence of the control system 70. The protein reagent supplying apparatus 52 is electrically connected to the control system 70 for supplying various reagents for performing specific protein detection to at least two protein reactors 315 in the protein detecting apparatus 30 under the action of the control system 70. The most commonly used reagents include two classes: one is a treatment reagent for performing basic treatment on a blood sample, such as a hemolysis agent, a diluent, etc., and the other is a latex reagent for detecting a specific protein, such as a C-reactive protein latex, a serum amyloid a latex, etc.

In some embodiments, the protein reagent delivery device 52 includes a pretreatment reagent delivery mechanism 521 and a latex reagent delivery mechanism 522 disposed on the housing 10. Wherein the pretreatment reagent supply mechanism 521 and the latex reagent supply mechanism 522 are independent of each other to avoid mutual contamination of the reagent in the pretreatment reagent supply mechanism 521 and the reagent in the latex reagent supply mechanism 522.

The pretreatment reagent supply mechanism 521 is configured to supply the corresponding treatment reagents to the at least two protein reactors 315, respectively. The pretreatment reagent supply mechanism 521 includes a first power mechanism, a first control valve, and a pretreatment reagent container connected to a pipeline. Wherein the pipeline is further connected to at least two protein reactors 315 via a second connection port 3153. The first power mechanism and first control valve are coupled to a control system 70 for placing a pretreatment reagent container. The first power mechanism is used for injecting the pretreatment reagent in the pretreatment reagent container into the pipeline. In some embodiments, the first power mechanism may be a fixed displacement pump, syringe, cylinder, or negative pressure source. The first control valve is adapted to be opened and closed under the control of the control system 70 to inject the desired pretreatment reagents into at least two specific protein reaction vessels 320 via tubing under the influence of the first power mechanism. In some embodiments, the number of pretreatment reagent containers may be plural, and the number of corresponding first power mechanisms may be plural. The number of the first control valves may be set as needed, and is not particularly limited herein.

The latex reagent supply mechanism 522 is configured to supply corresponding latex reagents to at least two protein reactors 315. The latex reagent supply mechanism 522 includes a second power mechanism, a second control valve, a latex reagent container 5220, and a reagent needle mechanism 5221 coupled to the control system 70. The latex reagent container 5220 is used for placing latex reagent, the latex reagent container 5220 has an extraction port 5221 for extracting reagent, and the reagent needle mechanism 5221 is configured to be capable of planar rotational movement and linear movement under the control of the control system 70 to reach the extraction port 5221 and the second injection port 3150. The second power mechanism and second control valve are used to inject latex reagent into at least two specific protein reaction vessels 3150 through the reagent needle mechanism 5221 under the control of the control system 70. In some embodiments, the number of latex reagent containers 5220 can be multiple, as can the number of corresponding second power mechanisms. The number of the second control valves may be set as needed, and is not particularly limited herein.

The reagent needle mechanism 5221 is used to collect the reagent in the latex reagent supply mechanism 522 and dispense the reagent to the at least one protein reactor 315 as desired. In some embodiments of the present application, the reagent needle mechanism 5221 can be further used to stir the blood reaction solution in the at least two protein reactors 315, so that the blood reaction solution in the at least two protein reactors 315 is more uniform, and the detection result is more accurate.

In some embodiments, the workflow of the protein reagent feeding apparatus 50 is: the control system 70 controls the first power mechanism and the first control valve to inject a desired pretreatment reagent into at least two specific protein reaction containers 320 through the pipeline, the control system 70 controls the reagent needle mechanism 5221 to perform a planar rotation motion and a vertical motion according to instructions of a measurement mode to move the reagent needle mechanism 5221 to the extraction port 5221 and the second injection port 3150, and collects and dispenses at least one latex reagent into at least one protein reactor 315 through the reagent needle mechanism 5221 by controlling the second power mechanism and the second control valve.

Drive device 60

In some embodiments, the driving device 60 is configured to drive the at least two protein reactors 315 and the protein detection mechanism 32 to perform a relative motion, such as a relative linear motion or a relative circular motion. In some embodiments, the driving device 60 is electrically connected to the control system 70, and can drive the at least two protein reactors 315 to move relative to the protein detection mechanism 32 under the control of the control system 70, so that the at least two protein reactors 315 are sequentially located in the detection channel of the protein detection mechanism 32.

In some embodiments, the drive device 60 is coupled to the protein reaction mechanism 31 for driving the movement of at least two protein reactors 315 relative to the housing 10. In this embodiment, the protein detection mechanism 32 is immobilized relative to the housing 10 such that at least two protein reactors 315 are in relative motion with the protein detection mechanism 32.

In some embodiments, the drive device 60 may drive the at least two protein reactors 315 in relative linear motion with respect to the housing 10. Referring to fig. 6-7, the drive 60 includes a first rail 63 and a first slider 64 mounted on a reactor mounting assembly 314. The first rail 63 may be mounted to the base plate 3111 through mounting holes 31110.

The driving device 60 includes a first driving member 61 disposed on one side of the side plate 3112, and a first synchronization assembly 62 disposed on the other side of the side plate 3112 and connected to the first driving member 61. The driving device 60 may also be mounted to the side plate 3112 through mounting holes 31123.

The first driving member 61 may be specifically connected and fixed to the side plate 3112 by screwing, plugging, buckling, welding, bonding, or the like. The first driving member 61 may be a motor. The output shaft of the motor may extend through the side plate 3112 and into the other side of the side plate 3112, and further connect with the first synchronization assembly 62. In an embodiment, the first driving member 61 may be another power source capable of driving the first synchronization assembly 62 to move, which will not be described in detail. The first driver 61 is electrically connected to the control system 70 for movement under the control of the control system 70.

The first synchronizing assembly 62 includes a first driving wheel 62a, a first driven wheel 62b and a first synchronizing mechanism 62c on a side facing away from the first drive member 61. The first synchronizing assembly 62 is movable under the influence of the first drive 61.

The first driving wheel 62a is disposed on the output shaft of the first driving member 61, and the rotation shaft of the first driving wheel 62a is disposed parallel to the output shaft of the first driving member 61.

The first driven wheel 62b may be disposed at a distance from the first driving wheel 62a, and a rotation axis of the first driven wheel 62b is disposed in parallel with an output shaft of the first driving member 61.

The first synchronization mechanism 62c is provided in contact with the first driving wheel 62a and the first driven wheel 62 b. In some embodiments, the first synchronization mechanism 62c may be a synchronous belt, and a synchronous belt sleeve is disposed outside the first driving wheel 62a and the first driven wheel 62 b. The reactor mounting assembly 314 may be mounted to the first synchronization mechanism 62c and at least two protein reactors 315 are coupled to the first synchronization mechanism 62c via the reactor mounting assembly 314. The first synchronization assembly 62 is driven by the first driving member 61 to move at least two protein reactors 315. Specifically, in some embodiments, the mount body 3141a and the clasp 3141b are provided on the first synchronization mechanism 62 c. In some embodiments, the fastener body 3141a and the clasp are disposed on either side of the timing belt.

The first driving wheel 62a rotates when the first driving member 61 is turned on. The first synchronization mechanism 62c moves under the action of the first driving wheel 62a and drives the first driven wheel 62b to synchronously rotate.

At least two protein reactors 315 may be connected to the drive 60 via a reactor mounting assembly 314. The drive 60 moves at least two protein reactors 415 by driving the reactor mounting assembly 314. In some embodiments, at least two protein reactors 315 are connected to the first synchronization mechanism 62c by a reactor mounting assembly 314. The first synchronization assembly 62 is driven by the first driving member 61 to move at least two protein reactors 315.

The first guide rail 63 may be mounted on the base 311 by screwing, plugging, buckling, welding, bonding, or the like. In some embodiments, the first rail 63 may be mounted to the base plate 3111 through mounting holes 31110. The extending direction of the first guide rail 63 and the extending direction of the timing belt are parallel to the extending direction of the groove 3230.

The first slider 64 is slidingly connected to the first rail 63 and to at least two protein reactors 315. In some embodiments, the first slider 64 may be U-shaped and define a recess 640. The first slider 64 is slidably coupled to the first rail 63 via the groove 640. The first slider 64 may be screwed, inserted, snapped, welded, glued, etc. onto the carrier 3142. In some embodiments, the first slider 64 is disposed on a side of the bearing mechanism 3142 away from the fixing member 3141. The at least two protein reactors 315 can be guided to do linear motion relative to the housing along the extending direction of the first guide rail by the cooperation of the first slider 64 and the first guide rail 63, so that the at least two protein reactors sequentially enter the detection channel.

The present application can guide the at least two protein reactors 315 to do reciprocating rectilinear motion relative to the protein detection mechanism 32 according to a given direction by sliding the first slider 64 on the first guide rail 63, so that one of the at least two protein reactors 315 is located in a detection channel of the protein detection mechanism 32, so as to realize detection of the blood sample reaction liquid in the at least two protein reactors 315 by the one protein detection mechanism 32, and obtain protein parameter detection.

In some embodiments, the number of at least two protein reactors 315 is 3, labeled a, b, and c, respectively, as shown in fig. 9, and the at least two protein reactors 315 and the protein detection mechanism 32 may perform a relative linear motion, which is specifically described as follows: the driving device 60 drives the 3 protein reactors 315a, 315b and 315c to slide along the extending direction of the first guide rail 63 through the first sliding block 64 under the control of the control system 70, so that the protein reactor 315a is positioned in a detection channel of the protein detection mechanism 32, and the protein detection mechanism 32 completes detection of a sample to be detected in the protein reactor a through the optical emitter 324 and the optical receiver 325 under the control of the control system 70; the driving device 60 drives the 3 protein reactors 315a, 315b and 315c to slide along the extending direction of the first guide rail 63 through the first sliding block 64 under the control of the control system 70, so that the protein reactor 315b is located in a detection channel of the protein detection mechanism 32, and the protein detection mechanism 32 completes detection of a sample to be detected in the protein reactor 315b through the optical emitter 324 and the optical receiver 325 under the control of the control system 70; the driving device 60 drives the 3 protein reactors 315a, 315b and 315c to slide along the extending direction of the first guide rail 63 through the first slider 64 under the control of the control system 70, so that the protein reactor 315c is located in the detection channel of the protein detection mechanism 32, and the protein detection mechanism 32 completes the detection of the sample to be detected in the protein reactor 315b through the optical emitter 324 and the optical receiver 325 under the control of the control system 70, so that protein detection parameters of the sample to be detected in the 3 protein reactors can be obtained.

In other embodiments, the driving device 60 includes a disc 65, where the disc 65 defines at least two limiting holes for mounting at least two protein reactors 315, and the at least two limiting holes are disposed in one-to-one correspondence with the at least two protein reactors 315. The disk 65 is electrically connected to the control system 70 and is rotatable under the influence of the control system 70. The rotation of the disc 65 may drive the at least two protein reactors 315 to perform a relative circular motion with respect to the housing 10, so that the at least two protein reactors 315 and the protein detection mechanism 32 perform a relative circular motion. As shown in fig. 10, the 3

protein reactors

315a, 315b, 315c may move along a circle to reduce the volume of the sample analysis apparatus 100, making the sample analysis apparatus 100 compact as a whole.

In addition, in other embodiments, the driving device 60 is connected to the protein detecting mechanism 32, and is used for driving the protein detecting mechanism 32 to perform a relative motion, such as a relative linear motion or a relative circular motion, relative to the housing 10. In this embodiment, at least two protein reactors 315 are immobilized relative to housing 10 such that relative movement of protein detection mechanism 32 and at least two protein reactors 315 occurs.

Control system 70

The control system 70 is coupled to the sample collection and distribution device 40, the blood routine detection device, the protein detection device 30 and the reagent supply device 50, and the control system 70 is configured to configure at least one protein detection mode for at least one protein reactor, control the sample collection and distribution device 40 to collect a sample to be detected according to the detection mode of the sample to be detected and distribute the collected sample to the blood routine reactor 21 and/or the at least two protein reactors 315, control the reagent supply device 50 to provide corresponding reagents for the corresponding blood routine reactor 21 and/or the at least two protein reactors 315 in the detection mode, so as to react with the sample to be detected distributed to the blood routine reactor 21 and/or the at least two protein reactors 315 to form a sample reaction liquid, control the at least two protein reactors 315 to perform relative movement with the protein detection mechanism 32, or control the sample reaction liquid in the blood routine reactor 21 and/or the at least two protein detection mechanism 315 to perform detection to obtain corresponding blood routine detection parameters and/or at least two specific protein reaction parameters.

It should be noted that the above embodiments of the present application are merely exemplary, and that the blood sample does not necessarily include all the devices, mechanisms, or elements, etc. described above, and that some devices, mechanisms, or elements, etc. may be omitted or added according to actual needs without changing the essential structure of the present application.

Also provided in some embodiments of the present application is a method of performing sample analysis based on the sample analysis device 100 described above. Referring to fig. 18, the specific steps may be as follows:

step S101, at least one protein reactor is configured with a corresponding protein detection mode.

In some embodiments, the control system can configure at least one protein reactor with a corresponding protein detection mode, such as a C-reactive protein detection mode or a serum amyloid A detection mode, as desired. For example, when there is only one sample to be tested and only one protein parameter needs to be obtained, the control system may configure the corresponding protein detection mode for only one of the specific protein detectors.

In some embodiments, when there are multiple samples to be tested or different specific protein detection needs to be performed on the same sample to be tested, the control system may configure the at least two protein reactors with corresponding protein detection modes. In some embodiments, the control system may configure at least two protein reactors with the same protein detection mode, e.g., both configured with a C-reactive protein detection mode or both configured with a serum amyloid a detection mode. In other embodiments, the control system may configure at least two protein reactors with different protein detection modes, respectively. For example: the control system configures a C-reactive protein detection mode for one of the protein reactors and a serum amyloid a detection mode for the other protein reactor.

Step S102, the sample collection and distribution device collects samples to be tested.

In some embodiments, as shown in fig. 19, step S102 may include the following steps:

step S1021: the first moving mechanism moves the sample needle to a sample sucking position;

the second driving piece can drive the second synchronous component to move under the control of the control system; under the action of the second synchronous component, the movable support can move along the second guide rail in the horizontal direction to the direction close to the test tube through the second sliding block, so that the sample needle on the movable support can move to a sample sucking position.

Step S1022: the second moving mechanism moves the sample needle into the test tube at the sample sucking position;

in some embodiments, under the control of the control system, the transmission mechanism in the second moving mechanism can drive the sample needle to approach the test tube along the third guide rail in the vertical direction, so that the sample needle on the movable support can be moved into the test tube at the sample sucking position.

Step S1023: the sample needle sucks a preset amount of sample to be detected and stores the sample inside the sample needle.

In some embodiments, the sample needle can absorb a preset amount of sample by the power provided by the liquid path support module, and the sample is stored in the sample needle, so that the sample collection action is completed.

Step S103: the sample collecting and distributing device distributes a sample to be tested to at least one corresponding protein reactor;

in some embodiments, referring to fig. 20, step S103 includes the steps of:

step S1031: the second moving mechanism moves the sample needle to a sample sucking position;

in some embodiments, under the control of the control system, the drive mechanism drives the sample needle to move along the third rail in a direction away from the test tube in a vertical direction, thereby moving the sample needle located in the movable rack to the sample aspirating position.

Step S1032: a first movement mechanism moves a sample needle in the sample collection and dispensing device to a sample dispensing position above a second injection port of the respective at least one protein reactor;

in some embodiments, the second driving member may drive the second synchronizing assembly to move under the control of the control system, and the movable rack may move in a horizontal direction away from the test tube along the second guide rail by the second slider under the action of the second synchronizing assembly, so that the sample needle on the movable rack moves to a sample dispensing position above the second injection port of the corresponding protein reactor. The control system controls the sample needle to move to the upper part of the corresponding protein reactor, and the sample needle can be divided into the following specific cases according to actual needs: when only one blood sample only needs to obtain one protein detection parameter, the control system controls the sample needle to move to the position above the corresponding protein reactor; when only one blood sample needs to obtain at least two protein detection parameters, the control system controls the sample needle to move to the position above the corresponding at least two protein reactors; when there are at least two blood samples to be obtained to one protein detection parameter, the control system controls the sample needle to move over the corresponding at least two protein reactors.

It will be appreciated that the sample needle is not moved to the sample dispensing position over the second injection port of at least two protein reactors simultaneously, but is moved to one of the two positions after dispensing of the sample is completed and then to the other position for dispensing of the sample.

Step S1033: a second moving mechanism moves the sample needle into the corresponding at least one protein reactor;

in some embodiments, the drive mechanism in the second movement mechanism drives the sample needle vertically along the third rail into the respective at least one protein reactor under control of the control system.

Step S1034: the sample needle quantifies the sample to be measured stored inside the sample needle into at least one protein reactor.

In some embodiments, after the tip of the sample needle reaches the corresponding at least one protein reactor, the control system controls the liquid path support module to provide power to quantitatively push out the sample to be measured stored in the sample needle, and the sample is added into the corresponding at least one protein reactor to complete the sample distribution action.

It should be noted that, when the blood routine test is needed, step S103 further includes controlling the sample collection and distribution device by the control system to distribute the sample to be tested to the blood routine reactor.

In step S104, the reagent supplying apparatus supplies the reaction reagent to the corresponding at least one protein reactor according to the configuration protein detection mode.

In some embodiments, referring to fig. 21, step S104 may include the steps of:

step S1041: a pretreatment reagent supply mechanism for dispensing a pretreatment reagent into the respective at least one protein reactor;

the control system controls the first power mechanism and the first control valve to inject the desired pretreatment reagents into at least two specific protein reaction vessels 320 via tubing.

Step S1042: the reagent needle dispenses the latex reagent in the latex reagent supply mechanism into the corresponding at least one protein reactor according to the configured protein detection mode.

The control system may dispense the respective latex reagent into the respective at least one protein reactor according to a predetermined detection pattern.

Specifically, in some embodiments, the control system controls the reagent needle mechanism to perform planar rotation motion according to the instruction of the measurement mode so as to move the reagent needle to the extraction port, then controls the vertical movement mechanism to drive the reagent needle mechanism to move vertically into the at least one latex reagent container 5220, and drives the reagent needle mechanism to collect at least one latex reagent, for example, C-reactive protein latex or serum amyloid a latex, through controlling the second power mechanism and the second control valve, and stores the latex reagent in the reagent needle mechanism to collect the latex reagent; the control system controls movement of the reagent needle mechanism 5221 in a vertical direction away from the latex reagent container 5220 and then controls the reagent needle to perform a planar rotational movement to move the reagent needle mechanism to the second injection port and drive the reagent needle by controlling the second power mechanism and the second control valve to dispense a desired amount of at least one latex reagent into the at least one protein reactor. It will be appreciated that when multiple latex reagents need to be collected, the multiple latex reagents are not collected at the same time to prevent interference of the multiple latex reagents.

Step S105: the at least two protein reactors and the protein detection mechanism perform relative movement, so that the at least two protein reactors sequentially enter the detection channel;

in some embodiments, the drive means drives the protein detection mechanism in a movement relative to the housing under the control of the control system, wherein the at least two protein reactors remain stationary relative to the housing such that the at least two protein reactors move relative to the protein detection mechanism into the detection channel in sequence. In other embodiments, the drive means drives the at least two protein reactors in relation to the housing under the control of the control system, wherein the protein detection mechanism remains stationary in relation to the housing such that the at least two protein reactors move in relation to the protein detection mechanism into the detection channel in sequence. The target position detector may simultaneously detect whether a corresponding protein reactor is located in the detection channel and adjust the corresponding protein reactor not located in the detection channel such that the corresponding protein reactor is located in the detection channel such that the optical signal emitted by the optical emitter is able to pass through the corresponding protein reactor and be received by the optical receiver. In some embodiments, when it is desired to detect a sample to be detected in at least two protein reactors, the control system controls the at least two protein reactors to move relative to the protein detection mechanism, so that the at least two protein reactors sequentially move into the detection channel of the protein detection mechanism.

Step S106: the protein detection mechanism sequentially detects the sample to be detected in the corresponding protein reactor entering the detection channel to obtain protein parameters.

Under the control of the control system, the optical signal light emitter emits optical signals, and the optical signals penetrate through the blood sample reaction liquid in the corresponding protein reactor. The optical receiver receives an optical signal transmitted through the blood sample reaction liquid. The optical signals are received by the control system and processed to form corresponding protein parameters.

In this application embodiment, two at least protein reactors and protein detection mechanism can take place relative movement to make a protein detection mechanism detectable sample that awaits measuring in a plurality of protein reactors, on the one hand can reduce because the different systematic error that brings of protein detection mechanism, detection data is more accurate, on the other hand also can reduce the cost of protein detection mechanism, has avoided the waste of material.

The order of the steps is not limited to the above-described embodiment, and all the steps are not necessarily included, and for example, in some examples, only steps S101, S105, and S106 may be included. In practical application, the appropriate steps and sequences may be selected for testing according to the product structure and the requirements for testing blood samples, and the like, and are not particularly limited herein.

It should be noted that, in the blood sample detection apparatus in the above embodiment utilized in the method for detecting a blood sample in the present application, the positions, materials, dimensions, functions, etc. of the element structures involved in the detection method may be the same as those in the embodiment of the blood sample detection apparatus in the present application, and details thereof will be omitted herein.

While the foregoing is directed to the preferred embodiments of the present application, it will be appreciated by those skilled in the art that changes and modifications may be made without departing from the principles of the present application, such changes and modifications are also intended to be included within the scope of the present application.

Claims

1. A sample analysis apparatus for testing a blood sample to obtain a test parameter, comprising:

a housing; and

protein detection apparatus, set up in the casing, include:

the protein reaction mechanism comprises at least two protein reactors and is used for accommodating a sample to be tested; and

the protein detection mechanism is provided with a detection channel and is used for detecting a sample to be detected in the detection channel;

the at least two protein reactors and the protein detection mechanism can perform relative movement, so that the at least two protein reactors sequentially enter the detection channel, and the protein detection mechanism sequentially detects samples to be detected in the at least two protein reactors.

2. The sample analysis device of claim 1, wherein the relative motion between the at least two protein reactors and the protein detection mechanism is linear or circular.

3. The sample analysis device of claim 1, further comprising a drive means coupled to the protein reaction mechanism for driving the at least two protein reactors in motion relative to a housing to which the protein detection mechanism is secured.

4. A sample analysis apparatus as claimed in claim 3, wherein the drive means comprises a turntable for carrying the at least two protein reactors and is configured to drive the at least two protein reactors in a circular motion relative to the housing such that the at least two protein reactors enter the detection channel in sequence.

5. A sample analysis device as claimed in claim 3, in which the drive means comprises:

the first guide rail is arranged on the shell; and

the first sliding block is in sliding connection with the first guide rail and is connected with the at least two protein reactors, so that the at least two protein reactors are guided to do linear motion relative to the shell along the extending direction of the first guide rail through the matching of the first sliding block and the first guide rail, and the at least two protein reactors sequentially enter the detection channel.

6. The sample analysis device of claim 1, wherein the protein detection mechanism defines a channel, a portion of which serves as the detection channel;

the at least two protein reactors are configured to be movable within the channel relative to the protein detection mechanism.

7. The sample analysis device of claim 6, wherein the channel is linear and the at least two protein reactors are relatively linear along the channel; or alternatively, the process may be performed,

the groove is in a circular ring shape, and the at least two protein reactors can do relative circular motion along the groove.

8. The sample analysis device of claim 1, further comprising a drive means coupled to the protein detection mechanism for driving the protein detection mechanism in motion relative to the housing, the at least two protein reactors being secured to the housing.

9. The sample analysis device of claim 1, further comprising: the control system is arranged on the shell and electrically connected with the protein detection device, and is used for controlling the protein detection mechanism to move relative to the at least two protein reactors and controlling the protein detection mechanism to detect a sample to be detected in the protein reactors in the detection channel so as to obtain protein parameters.

10. The sample analysis device of claim 1, further comprising:

the sample collecting and distributing device is movably connected with the shell and is used for collecting and distributing the sample to be tested;

the blood routine detection device is arranged in the shell and is used for carrying out blood routine detection;

a reagent supply device arranged in the shell and used for providing a reagent for the sample to be tested; and

the blood routine detection device, the reagent supply device and the protein detection device are distributed along the moving path of the sample collecting and distributing device.

11. The blood sample detection method is applied to sample analysis equipment and is characterized by comprising a shell and a specific protein detection device, wherein the specific protein detection device is arranged in the shell and comprises a protein reaction mechanism and a protein detection mechanism, the protein reaction mechanism comprises at least two protein reactors, the at least two protein reactors are used for bearing a sample to be detected, and the protein detection mechanism is provided with a detection channel;

The protein detection method comprises the following steps:

the at least two protein reactors and the protein detection mechanism perform relative movement, so that the at least two protein reactors sequentially enter the detection channel;

the protein detection mechanism sequentially detects the sample to be detected in the corresponding protein reactor entering the detection channel so as to obtain protein parameters.

12. The method according to claim 11, wherein in the step of relatively moving the at least two protein reactors and the protein detecting mechanism, the relative movement between the at least two protein reactors and the protein detecting mechanism is linear movement or circular movement.

13. The method of claim 11, wherein the sample analysis device further comprises a drive device coupled to the protein reaction mechanism;

the step of enabling the at least two protein reactors to enter the detection channel in sequence comprises the following steps of:

the driving device drives the at least two protein reactors to move relative to the shell; wherein the protein detection mechanism is held stationary relative to the housing such that the at least two protein reactors move relative to the protein detection mechanism into the detection channel in sequence.

14. The method of claim 11, wherein the sample analysis device further comprises a control system coupled to the protein reaction mechanism and the protein detection mechanism, the method further comprising, prior to the step of moving the at least two protein reactors and the protein detection mechanism relative to each other:

the control system configures corresponding protein detection modes for at least two protein reactors;

in the relative movement step of the at least two protein reactors and the protein detection mechanism, the control system controls the at least two protein reactors to perform relative linear movement or relative circular movement relative to the shell so that the at least two protein reactors sequentially enter the protein detection mechanism; wherein the protein detection mechanism remains stationary relative to the housing; or (b)

The control system controls the protein detection mechanism to perform relative linear motion or relative circular motion relative to the shell so that the at least two protein reactors sequentially enter the protein detection mechanism; wherein the at least two protein reactors remain stationary relative to the housing.