CN116115722A - Traditional Chinese medicine composition eye ointment for preventing and treating hyperopia of children and teenagers and preparation method thereof - Google Patents

Traditional Chinese medicine composition eye ointment for preventing and treating hyperopia of children and teenagers and preparation method thereof Download PDF

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CN116115722A
CN116115722A CN202310226025.2A CN202310226025A CN116115722A CN 116115722 A CN116115722 A CN 116115722A CN 202310226025 A CN202310226025 A CN 202310226025A CN 116115722 A CN116115722 A CN 116115722A
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chinese medicine
traditional chinese
children
eye ointment
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CN116115722B (en
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张惠珍
狄浩浩
冯思颉
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Henan University of Technology
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Abstract

The invention discloses a traditional Chinese medicine composition eye ointment for preventing and treating hyperopia of children and teenagers and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine composition eye ointment for preventing and treating the hyperopia of the children and the teenagers comprises the following components in parts by weight: traditional Chinese medicine mixture: 47-79 parts of auxiliary materials: 421-579 parts; the traditional Chinese medicine mixture comprises the following components: radix rehmanniae Preparata, semen Cuscutae, radix Paeoniae alba, fructus Lycii, rhizoma Ligustici Chuanxiong, curcuma rhizome, folium Artemisiae Argyi, flos Chrysanthemi Indici, herba Senecionis Scandentis, pericarpium Citri Reticulatae viride, rhizoma Acori Graminei, and Margarita powder; the auxiliary materials comprise the following components: stearic acid, glyceryl monostearate, liquid paraffin, white vaseline, triethanolamine, glycerol, tween, methyl benzoate, potassium sorbate and Lithargyrum powder. Aiming at the pathogenesis of presbyopia caused by congenital deficiency of children and teenagers, the invention provides the traditional Chinese medicine formula paste for tonifying liver and kidney, tonifying qi and blood, dredging meridian passage and inducing resuscitation and improving eyesight, which is matched with a special use method, is self-taken by children, and is safe and effective.

Description

Traditional Chinese medicine composition eye ointment for preventing and treating hyperopia of children and teenagers and preparation method thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicine preparation, and in particular relates to traditional Chinese medicine composition eye ointment for preventing and treating hyperopia of children and teenagers and a preparation method thereof.
Background
Unlike myopia, the cause of childhood presbyopia is not overuse of the eye, but a congenital condition that begins at the fetal stage. Children with hyperopia develop slowly, have difficulty in looking far and near, and have greater daily eye pressure. In addition, the social information network is rapidly developed, the short-distance ocular tension is larger and larger in life, study and work of people, the school of children and teenagers is heavy, the ocular time and intensity are greatly increased before, so that serious ocular fatigue, eyeball pain, dizziness, nausea and other discomfort can be easily caused for children and teenagers with hyperopia, and serious hyperopia is often accompanied with amblyopia and strabismus. The children's life, study and growth are greatly influenced.
Currently, methods for preventing and treating presbyopia include wearing glasses, laser surgery, and the like. Besides the defect of treating the symptoms without treating the root causes, the laser surgery has potential side effects on eyes. The method for preventing and treating presbyopia by traditional Chinese medicine comprises acupuncture points, eye plaster, massage, etc. The traditional Chinese medicine of the eye ointment is insufficient in compatibility of medicines and is not specific, and the prescription is general and is used for all patients with ametropia including presbyopia. In fact, the causes of childhood presbyopia and myopia are fundamentally different. Myopia is caused by overuse of the eyes, while hyperopia is congenital disease, liver and kidney deficiency, deficiency of qi and blood, and inability to see eyes. Presbyopia has its own specific pathogenesis, and should be treated by syndrome differentiation alone and the prescription should be dispatched alone.
At present, no traditional Chinese medicine formula eye cream specially aiming at independent dialectical treatment of congenital presbyopia of children and teenagers exists, and the invention can fill the gap. The eye ointment has unique formula, is safe and convenient to use, can effectively promote the rehabilitation of presbyopia of children and teenagers, and can help the eyesight health of children.
Disclosure of Invention
Aiming at the pathogenesis of presbyopia caused by congenital deficiency of children and teenagers, the invention provides the traditional Chinese medicine formula paste for tonifying liver and kidney, tonifying qi and blood, dredging meridian passage and inducing resuscitation and improving eyesight, which is matched with a special use method, is self-taken by children, and is safe and effective.
In order to achieve the technical purpose, the invention adopts the following technical scheme.
A traditional Chinese medicine composition eye ointment for preventing and treating children and teenagers from hyperopia is prepared from a traditional Chinese medicine composition and auxiliary materials in parts by weight:
47-79 parts of a traditional Chinese medicine mixture,
421-579 parts of auxiliary materials.
A traditional Chinese medicine composition eye ointment for preventing and treating children and teenagers from hyperopia is prepared from a traditional Chinese medicine mixture and auxiliary materials in parts by weight:
63 parts of a Chinese medicinal mixture,
500 parts of auxiliary materials.
The traditional Chinese medicine mixture comprises the following components in parts by weight:
Figure BDA0004118477740000021
the traditional Chinese medicine mixture comprises the following components in parts by weight:
Figure BDA0004118477740000022
Figure BDA0004118477740000031
the traditional Chinese medicine mixture comprises the following components in parts by weight:
Figure BDA0004118477740000032
wherein, the auxiliary materials comprise the following components in parts by weight:
Figure BDA0004118477740000033
wherein, the auxiliary materials comprise the following components in parts by weight:
Figure BDA0004118477740000034
Figure BDA0004118477740000041
a preparation method of a traditional Chinese medicine composition eye ointment for preventing and treating hyperopia of children and teenagers comprises the following steps:
(1) The Chinese medicinal composition is prepared by decocting the filtrate: mixing radix rehmanniae Preparata, semen Cuscutae, radix Paeoniae alba, fructus Lycii, rhizoma Ligustici Chuanxiong, curcuma rhizome, folium Artemisiae Argyi, flos Chrysanthemi Indici, herba Senecionis Scandentis, pericarpium Citri Reticulatae viride and rhizoma Acori Graminei, decocting in water for 2 times (1 hr each time), mixing decoctions, and filtering with 400 mesh sieve to obtain Chinese medicinal decoction;
(2) Preparing presbyopia ointment: mixing stearic acid, glyceryl monostearate, liquid paraffin and white vaseline to obtain an oil phase, mixing the Chinese medicinal decoction, triethanolamine, glycerol, tween, methyl benzoate and potassium sorbate to obtain water phase, respectively heating the oil phase and water phase to 85deg.C in water, slowly pouring the oil phase into the water phase, stirring to obtain cream with milky yellow and semisolid, cooling the cream to 55deg.C, adding Margarita powder and Lithargyrum powder, and stirring for 2 hr until the cream is condensed.
Compared with the prior art, the invention has the beneficial effects that:
aiming at the specific pathogenesis of presbyopia of children and teenagers, the invention has the advantages of full and specific syndrome differentiation, low price of traditional Chinese medicine prescription, convenient use, safety and effectiveness.
The principal drugs in the invention are prepared rehmannia root and semen cuscutae, which are good drugs for tonifying deficiency, and have definite effect and mild effect. The children and teenagers hyperopia are congenital deficiency, liver and kidney deficiency, prepared rehmannia root, semen cuscutae liver and kidney deficiency and eye fluid, liquid, qi and blood deficiency, and the two components are monarch drugs, and the dosage is the largest. Far and near objects are unclear, so that the far and near objects are more prone to eyestrain than a near eye, qi, blood and body fluid are more prone to deficiency, channels and collaterals around eyes are blocked, and eyes cannot be seen. In the formula, white peony root, medlar supplements qi and blood, nourishes liver and kidney, szechuan lovage rhizome, turmeric and wormwood activate blood and remove stasis, warm meridians and dredge collaterals, and the medicines are ministerial medicines, and the dosage is slightly inferior to that of monarch medicines. Overuse of the eyes causes qi stagnation and fluid consumption in the eyes, deficiency of liver and kidney, and hyperactivity of fire due to yin deficiency. In the formula, the wild chrysanthemum flower, the groundsel herb, the heat and the toxin are cleared, the fire is discharged, the liver is calmed and the eyesight is improved; pearl powder for suppressing hyperactive liver, subsiding yang, nourishing liver yin, and improving eyesight. Qing Pi, with the actions of activating qi and resolving stagnation, is good at Shu Ganyu. The four are adjuvant drugs with small dosage. The grassleaf sweelflag rhizome has the advantages of pungent and fragrant smell, bitter and dry taste, warmth and general, and mild action, is suitable for children and teenagers to refresh and restore consciousness, and is the drug with the minimum dosage.
The presbyopia ointment of the invention is used in the following way, 3 times a day for 5 minutes each time. The eye ointment is applied on the periphery of the eye, and the index finger starts from the Ming acupoint of the eye of the eyebrow and goes from the upper orbit to the Tongziliao acupoint of the eyebrow, then goes to the temple, goes to the lower orbital margin, goes to the four-white acupoint, and finally goes to the inner canthus of the inner side of the nose, and then the index finger presses, is retracted and stays at the acupoint, and self feels soreness and distending pain.
Detailed Description
The invention is further described below in connection with specific embodiments.
Example 1
(one), articles preparation
1 stage of electronic balance;
1 stove;
1 pan;
2 beakers;
1 stage of stirrer;
2 thermometer at 100deg.C.
Secondly, preparing a Chinese medicinal composition water decoction filtrate
9 g of prepared rehmannia root, 9 g of semen cuscutae, 6 g of white paeony root, 6 g of medlar, 6 g of szechuan lovage rhizome, 6 g of turmeric, 6 g of wormwood, 3 g of wild chrysanthemum flower, 3 g of groundsel, 3 g of green tangerine peel and 3 g of grassleaf sweelflag rhizome;
the above components are placed in 10 times of water and decocted for 2 times, each time for 1 hour, the decocted liquid is combined and filtered by a 400-mesh sieve, and 1000 milliliters of Chinese medicinal composition water decocted filtrate is obtained.
(III) preparing presbyopia ointment
1. Stearic acid 100 g
2. Glyceryl monostearate 50 g
3. Liquid paraffin 50 g
4. White vaseline 100 g
5. 1000 ml of Chinese medicine decoction filtrate
6. Triethanolamine 50 g
7. Glycerol 100 g
8. Tween 10 g
9. Methyl paraben 5 g
10. Potassium sorbate 5 g
11. Pearl powder 3 g
12. Lithargyrum powder 30 g
Placing the components 1, 2, 3 and 4 in a beaker to form an oil phase; the components 5, 6, 7, 8, 9, 10 were placed in another beaker to be aqueous. And heating the two beakers to 85 ℃ in a water-proof manner at the same time, slowly pouring the oil phase into the water phase, and continuously stirring until the paste is milky yellow in the process, wherein the semisolid is the emulsified paste. Cooling the paste to 55deg.C, grinding the components 11 and 12 into powder, adding, and stirring for 2 hr until the paste is condensed.
And (3) notes:
1. ultraviolet lamp sterilization is needed for 2 hours in the manufacturing environment;
2. the container is manufactured by high-pressure sterilization;
3. the paste is stirred in the same direction so as to avoid whipping.
Example 2
(one), articles preparation
1 stage of electronic balance;
1 stove;
1 pan;
2 beakers;
1 stage of stirrer;
2 thermometer at 100deg.C.
Secondly, preparing a Chinese medicinal composition water decoction filtrate
6 g of prepared rehmannia root, 12 g of semen cuscutae, 5 g of white peony root, 7 g of medlar, 5 g of ligusticum wallichii, 7 g of turmeric, 5 g of wormwood, 2 g of wild chrysanthemum flower, 4 g of senecio scandens, 2 g of green tangerine peel and 4 g of grassleaf sweelflag rhizome;
the above components are placed in 10 times of water and decocted for 2 times, each time for 1 hour, the decocted liquid is combined and filtered by a 400-mesh sieve, and 1000 milliliters of Chinese medicinal composition water decocted filtrate is obtained.
(III) preparing presbyopia ointment
1. Stearic acid 90 g
2. Glyceryl monostearate 40 g
3. 40 g of liquid paraffin
4. White vaseline 90 g
5. 1000 ml of Chinese medicine decoction filtrate
6. Triethanolamine 40 g
7. Glycerol 90 g
8. Tween 8 g
9. Methyl paraben 3 g
10. Potassium sorbate 2 g
11. Pearl powder 2 g
12. Lithargyrum powder 15 g
Placing the components 1, 2, 3 and 4 in a beaker to form an oil phase; the components 5, 6, 7, 8, 9, 10 were placed in another beaker to be aqueous. And heating the two beakers to 85 ℃ in a water-proof manner at the same time, slowly pouring the oil phase into the water phase, and continuously stirring until the paste is milky yellow in the process, wherein the semisolid is the emulsified paste. Cooling the paste to 55deg.C, grinding the components 11 and 12 into powder, adding, and stirring for 2 hr until the paste is condensed.
And (3) notes:
1. ultraviolet lamp sterilization is needed for 2 hours in the manufacturing environment;
2. the container is manufactured by high-pressure sterilization;
3. the paste is stirred in the same direction so as to avoid whipping.
Example 3
(one), articles preparation
1 stage of electronic balance;
1 stove;
1 pan;
2 beakers;
1 stage of stirrer;
2 thermometer at 100deg.C.
Secondly, preparing a Chinese medicinal composition water decoction filtrate
12 g of prepared rehmannia root, 6 g of semen cuscutae, 7 g of white peony root, 5 g of medlar, 7 g of ligusticum wallichii, 5 g of turmeric, 7 g of wormwood, 4 g of wild chrysanthemum flower, 2 g of groundsel, 4 g of green tangerine peel and 2 g of grassleaf sweelflag rhizome;
the above components are placed in 10 times of water and decocted for 2 times, each time for 1 hour, the decocted liquid is combined and filtered by a 400-mesh sieve, and 1000 milliliters of Chinese medicinal composition water decocted filtrate is obtained.
(III) preparing presbyopia ointment
1. Stearic acid 110 g
2. Glyceryl monostearate 60 g
3. Liquid paraffin 60 g
4. White vaseline 110 g
5. 1000 ml of Chinese medicine decoction filtrate
6. Triethanolamine 60 g
7. Glycerol 110 g
8. Tween 12 g
9. Methyl paraben 7 g
10. Potassium sorbate 7 g
11. Pearl powder 4 g
12. Lithargyrum powder 40 g
Placing the components 1, 2, 3 and 4 in a beaker to form an oil phase; the components 5, 6, 7, 8, 9, 10 were placed in another beaker to be aqueous. And heating the two beakers to 85 ℃ in a water-proof manner at the same time, slowly pouring the oil phase into the water phase, and continuously stirring until the paste is milky yellow in the process, wherein the semisolid is the emulsified paste. Cooling the paste to 55deg.C, grinding the components 11 and 12 into powder, adding, and stirring for 2 hr until the paste is condensed.
And (3) notes:
1. ultraviolet lamp sterilization is needed for 2 hours in the manufacturing environment;
2. the container is manufactured by high-pressure sterilization;
3. the paste is stirred in the same direction so as to avoid whipping.
Example 4
(one), articles preparation
1 stage of electronic balance;
1 stove;
1 pan;
2 beakers;
1 stage of stirrer;
2 thermometer at 100deg.C.
Secondly, preparing a Chinese medicinal composition water decoction filtrate
8 g of prepared rehmannia root, 10 g of semen cuscutae, 5 g of white peony root, 7 g of medlar, 5 g of ligusticum wallichii, 7 g of turmeric, 5 g of wormwood, 2 g of wild chrysanthemum flower, 4 g of senecio scandens, 2 g of green tangerine peel and 4 g of grassleaf sweelflag rhizome;
the above components are placed in 10 times of water and decocted for 2 times, each time for 1 hour, the decocted liquid is combined and filtered by a 400-mesh sieve, and 1000 milliliters of Chinese medicinal composition water decocted filtrate is obtained.
(III) preparing presbyopia ointment
1. Stearic acid 100 g
2. Glyceryl monostearate 50 g
3. Liquid paraffin 50 g
4. White vaseline 100 g
5. 1000 ml of Chinese medicine decoction filtrate
6. Triethanolamine 50 g
7. Glycerol 100 g
8. Tween 10 g
9. Methyl paraben 5 g
10. Potassium sorbate 5 g
11. Pearl powder 3 g
12. Lithargyrum powder 30 g
Placing the components 1, 2, 3 and 4 in a beaker to form an oil phase; the components 5, 6, 7, 8, 9, 10 were placed in another beaker to be aqueous. And heating the two beakers to 85 ℃ in a water-proof manner at the same time, slowly pouring the oil phase into the water phase, and continuously stirring until the paste is milky yellow in the process, wherein the semisolid is the emulsified paste. Cooling the paste to 55deg.C, grinding the components 11 and 12 into powder, adding, and stirring for 2 hr until the paste is condensed.
And (3) notes:
1. ultraviolet lamp sterilization is needed for 2 hours in the manufacturing environment;
2. the container is manufactured by high-pressure sterilization;
3. the paste is stirred in the same direction so as to avoid whipping.
Example 5
(one), articles preparation
1 stage of electronic balance;
1 stove;
1 pan;
2 beakers;
1 stage of stirrer;
2 thermometer at 100deg.C.
Secondly, preparing a Chinese medicinal composition water decoction filtrate
10 g of prepared rehmannia root, 8 g of semen cuscutae, 5 g of white peony root, 7 g of medlar, 5 g of ligusticum wallichii, 7 g of turmeric, 5 g of wormwood, 2 g of wild chrysanthemum flower, 4 g of senecio scandens, 2 g of green tangerine peel and 4 g of grassleaf sweelflag rhizome;
the above components are placed in 10 times of water and decocted for 2 times, each time for 1 hour, the decocted liquid is combined and filtered by a 400-mesh sieve, and 1000 milliliters of Chinese medicinal composition water decocted filtrate is obtained.
(III) preparing presbyopia ointment
1. Stearic acid 100 g
2. Glyceryl monostearate 50 g
3. Liquid paraffin 50 g
4. White vaseline 100 g
5. 1000 ml of Chinese medicine decoction filtrate
6. Triethanolamine 50 g
7. Glycerol 100 g
8. Tween 10 g
9. Methyl paraben 5 g
10. Potassium sorbate 5 g
11. Pearl powder 3 g
12. Lithargyrum powder 30 g
Placing the components 1, 2, 3 and 4 in a beaker to form an oil phase; the components 5, 6, 7, 8, 9, 10 were placed in another beaker to be aqueous. And heating the two beakers to 85 ℃ in a water-proof manner at the same time, slowly pouring the oil phase into the water phase, and continuously stirring until the paste is milky yellow in the process, wherein the semisolid is the emulsified paste. Cooling the paste to 55deg.C, grinding the components 11 and 12 into powder, adding, and stirring for 2 hr until the paste is condensed.
And (3) notes:
1. ultraviolet lamp sterilization is needed for 2 hours in the manufacturing environment;
2. the container is manufactured by high-pressure sterilization;
3. the paste is stirred in the same direction so as to avoid whipping.
Comparative example 1
(one), articles preparation
1 stage of electronic balance;
1 stove;
1 pan;
2 beakers;
1 stage of stirrer;
2 thermometer at 100deg.C.
Secondly, preparing a Chinese medicinal composition water decoction filtrate
Semen astragali complanati 9 g, semen cuscutae 9 g, radix paeoniae alba 6 g, fructus lycii 6 g, rhizoma ligustici wallichii 6 g, rhizoma curcumae longae 6 g, wormwood 6 g, green tangerine orange peel 3 g and rhizoma acori graminei 3 g;
the above components are placed in 10 times of water and decocted for 2 times, each time for 1 hour, the decocted liquid is combined and filtered by a 400-mesh sieve, and 1000 milliliters of Chinese medicinal composition water decocted filtrate is obtained.
(III) preparing presbyopia ointment
1. Stearic acid 100 g
2. Glyceryl monostearate 50 g
3. Liquid paraffin 50 g
4. White vaseline 100 g
5. 1000 ml of Chinese medicine decoction filtrate
6. Triethanolamine 50 g
7. Glycerol 100 g
8. Tween 10 g
9. Methyl paraben 5 g
10. Potassium sorbate 5 g
11. Pearl powder 3 g
12. Lithargyrum powder 30 g
Placing the components 1, 2, 3 and 4 in a beaker to form an oil phase; the components 5, 6, 7, 8, 9, 10 were placed in another beaker to be aqueous. And heating the two beakers to 85 ℃ in a water-proof manner at the same time, slowly pouring the oil phase into the water phase, and continuously stirring until the paste is milky yellow in the process, wherein the semisolid is the emulsified paste. Cooling the paste to 55deg.C, grinding the components 11 and 12 into powder, adding, and stirring for 2 hr until the paste is condensed.
And (3) notes:
1. ultraviolet lamp sterilization is needed for 2 hours in the manufacturing environment;
2. the container is manufactured by high-pressure sterilization;
3. the paste is stirred in the same direction so as to avoid whipping.
Description: comparative example 1 the same as in example 1 was repeated except that the prepared rehmannia root was replaced with semen astragali Complanati and the wild chrysanthemum flower and senecio in the prescription were deleted.
Comparative example 2
(one), articles preparation
1 stage of electronic balance;
1 stove;
1 pan;
2 beakers;
1 stage of stirrer;
2 thermometer at 100deg.C.
Secondly, preparing a Chinese medicinal composition water decoction filtrate
9 g of astragalus root, 9 g of ginseng, 6 g of angelica, 6 g of white peony root, 6 g of medlar, 6 g of turmeric, 6 g of wormwood, 3 g of wild chrysanthemum flower, 3 g of groundsel and 3 g of borneol. The above components are placed in 10 times of water and decocted for 2 times, each time for 1 hour, the decocted liquid is combined and filtered by a 400-mesh sieve, and 1000 milliliters of Chinese medicinal composition water decocted filtrate is obtained.
(III) preparing presbyopia ointment
1. Stearic acid 100 g
2. Glyceryl monostearate 50 g
3. Liquid paraffin 50 g
4. White vaseline 100 g
5. 1000 ml of Chinese medicine decoction filtrate
6. Triethanolamine 50 g
7. Glycerol 100 g
8. Tween 10 g
9. Methyl paraben 5 g
10. Potassium sorbate 5 g
11. Pearl powder 3 g
12. Lithargyrum powder 30 g
Placing the components 1, 2, 3 and 4 in a beaker to form an oil phase; the components 5, 6, 7, 8, 9, 10 were placed in another beaker to be aqueous. And heating the two beakers to 85 ℃ in a water-proof manner at the same time, slowly pouring the oil phase into the water phase, and continuously stirring until the paste is milky yellow in the process, wherein the semisolid is the emulsified paste. Cooling the paste to 55deg.C, grinding the components 11 and 12 into powder, adding, and stirring for 2 hr until the paste is condensed.
And (3) notes:
1. ultraviolet lamp sterilization is needed for 2 hours in the manufacturing environment;
2. the container is manufactured by high-pressure sterilization;
3. the paste is stirred in the same direction so as to avoid whipping.
Animal toxicity test
1. Acute periocular skin allergy test:
10 healthy guinea pigs with the age of 3 months are selected, the weight is 450-700g, and the male and female are half. The upper part of the guinea pig in the eyes was dehaired at about 1cm by 1cm in area 24 hours before administration. The presbyopia ointment of example 1 was uniformly smeared on the dehairing zone, the ointment and the eye ointment were removed after the fixation and closure with a medical non-irritating adhesive tape for 24 hours and 24 hours, the skin and systemic toxicant signs of the animals were observed for 7 days, and the animals were sacrificed by the neck pulling method after the test was completed to conduct general pathological observation.
Test results: the test animals did not die during the test period, the activities were fed normally, and no abnormalities were seen in the whole body skin. Cadavers were generally necropsied, and no obvious abnormalities were seen in heart, liver, spleen, lung, kidney.
Conclusion: guinea pig has no acute skin anaphylaxis to tested eye ointment
2. Acute conjunctival irritation test
6 healthy guinea pigs with the age of 3 months are selected, the weight is 450-700g, and the male and female are half. In the test, the water decoction of the traditional Chinese medicine composition obtained in the embodiment 1 of the application is placed to normal temperature, and is sucked by a sterile dropper, then 1 drop of the water decoction is dripped into the left eye of each guinea pig, and the right eye is used for comparison observation. 30min,1h,24h,48h,72h after dripping the test substance, and observing the conjunctival congestion of the eyes of the guinea pigs.
Test results: no ocular abnormalities were observed at each time point after instillation of the test article, and during the observation period, animals were fed normally with activity and no death.
Conclusion: the Chinese medicinal composition water decoction used in the application has no obvious irritation to guinea pig conjunctiva
Clinical data and preferences for presbyopia cream
1. Case sources
Collecting 160 hyperopic teenager patients from a certain ophthalmic hospital in Zhengzhou city from 11 months 2021 to 4 months 2022.
2. Diagnostic criteria and classification
Diagnostic criteria are formulated with reference to diagnosis and classification criteria for hyperopia in Chinese ophthalmology. The diagnosis criterion for hyperopia is a refractive error in which the eye, in a state of accommodation relaxation, after parallel rays pass through the refractive system of the eye, a focal point is formed behind the retina, and the axial length of the eyeball is smaller than the refractive power thereof.
Classification of hyperopia degree:
1) Mild presbyopia: farsightedness < +3.0D
2) Moderate presbyopia: hyperopia of +3.0D to +6.0D
3) High presbyopia: distance vision of > +6.0D
3. Exclusion criteria
1) Is not in compliance with the above diagnostic and inclusion criteria
2) Patients with other eye diseases and have influence on curative effect determination
3) Patients with other systemic diseases and mental diseases
4) Those undergoing other treatment methods
4. Grouping and treatment method
160 patients which are taken into observation are randomly divided into four groups according to the order of clinic visits, and all cases are completed in the whole process without falling cases. Before treatment, the comparison between the two groups of examination results has no statistical difference, and the data has comparability. Wherein, treatment of 1 group of 40 cases was given the presbyopia ointment treatment described in example 1, and applied 3 times daily over the observation period; treatment of group 2, 40 cases, with presbyopia ointment as described in comparative example 1, applied 3 times daily over the observation period; treatment of 3 groups of 40 cases, treatment with presbyopia ointment as described in comparative example 2 was given, and applied 3 times daily over the observation period; treatment of 4 groups of 40 cases, administration of cool compress gel with bosom and eye moistening effects, and application of cool compress gel with eye moistening effect was performed 3 times daily during observation period. After 2 months, the two groups of cases are subjected to index detection, and the curative effect is observed.
5. Effect determination
The use effect is divided into effective and ineffective.
The method is effective: the original subjective visual discomfort, such as blurred vision, eye soreness, eye distension, eye pain, headache and the like, disappears; or the wearing mirror power is reduced by more than 50 degrees; or the naked eyes are far away, and the near vision is improved by more than 0.1 compared with the prior art. Any one of the above steps is effective.
Invalidation: subjective visual discomfort such as blurred vision, eye soreness, eye distension, eye pain, headache, etc. still exists; or the lens wearing degree is unchanged; or the wearing power is deepened more forward; or the naked eyes are far away, and the near vision is not improved; or the naked eyes are far away, and the near vision is reduced by more than 0.1 compared with the front.
6. Statistical method
SPSS17.0 software was used for data processing. The pre-and post-treatment metering data of each group adopts paired t test, the comparison among groups adopts variance analysis, the test level a=0.05, and the difference is statistically significant when p is less than 0.05.
7. Observation result
Group of Eye ointment name Case (personal) Effective and effective Invalidation of Effective rate of
Treatment group 1 EXAMPLE 1 eye ointment 40 37 3 92.5%
Treatment group 2 Comparative example 1 eye ointment 40 32 8 80.0%
Treatment 3 groups Comparative example 2 eye ointment 40 31 9 77.5%
Treatment 4 groups Eye-moistening cold compress gel 40 28 12 70.0%
8. Conclusion(s)
The observation results show that the treatment of the treatment group 1 and the treatment group 2 can improve the clinical symptoms of teenager hyperopia patients, and compared with the eye-moistening cold compress gel, the treatment effect of the hyperopic ointment is more obvious. Also, the efficacy of comparative examples 1 and 2 was significantly lower than the ointment of example 1.
The foregoing is a further elaboration of the present invention in connection with the detailed description, and it is not intended that the invention be limited to the specific embodiments shown, but rather that a number of simple deductions or substitutions be made by one of ordinary skill in the art without departing from the spirit of the invention, should be considered as falling within the scope of the invention as defined in the appended claims.

Claims (8)

1. A traditional Chinese medicine composition eye ointment for preventing and treating children and teenagers from hyperopia is characterized by being prepared from a traditional Chinese medicine composition and auxiliary materials in parts by weight:
47-79 parts of a traditional Chinese medicine mixture,
421-579 parts of auxiliary materials.
2. The traditional Chinese medicine composition eye ointment for preventing and treating children and teenagers from hyperopia according to claim 2, which is characterized by being prepared from a traditional Chinese medicine mixture and auxiliary materials in parts by weight:
63 parts of a Chinese medicinal mixture,
500 parts of auxiliary materials.
3. The traditional Chinese medicine composition eye ointment for preventing and treating hyperopia of children and teenagers according to claim 1, wherein the eye ointment is characterized by: the traditional Chinese medicine mixture comprises the following components in parts by weight:
Figure FDA0004118477730000011
4. the traditional Chinese medicine composition eye ointment for preventing and treating hyperopia of children and teenagers according to claim 3, wherein the eye ointment is characterized in that: the traditional Chinese medicine mixture comprises the following components in parts by weight:
Figure FDA0004118477730000012
Figure FDA0004118477730000021
5. the traditional Chinese medicine composition eye ointment for preventing and treating hyperopia of children and teenagers according to claim 4, wherein the eye ointment is characterized by: the traditional Chinese medicine mixture comprises the following components in parts by weight:
Figure FDA0004118477730000022
6. the traditional Chinese medicine composition eye ointment for preventing and treating hyperopia of children and teenagers according to claim 1, wherein the eye ointment is characterized by: the auxiliary materials comprise the following components in parts by weight:
Figure FDA0004118477730000023
Figure FDA0004118477730000031
7. the traditional Chinese medicine composition eye ointment for preventing and treating hyperopia of children and teenagers according to claim 7, wherein the eye ointment is characterized in that: the auxiliary materials comprise the following components in parts by weight:
Figure FDA0004118477730000032
8. a method for preparing the traditional Chinese medicine composition eye ointment for preventing and treating hyperopia of children and teenagers according to any one of claims 1-7, which is characterized by comprising the following steps:
(1) The Chinese medicinal composition is prepared by decocting the filtrate: mixing radix rehmanniae Preparata, semen Cuscutae, radix Paeoniae alba, fructus Lycii, rhizoma Ligustici Chuanxiong, curcuma rhizome, folium Artemisiae Argyi, flos Chrysanthemi Indici, herba Senecionis Scandentis, pericarpium Citri Reticulatae viride and rhizoma Acori Graminei, decocting in water for 2 times (1 hr each time), mixing decoctions, and filtering with 400 mesh sieve to obtain Chinese medicinal decoction;
(2) Preparing presbyopia ointment: mixing stearic acid, glyceryl monostearate, liquid paraffin and white vaseline to obtain an oil phase, mixing the Chinese medicinal decoction, triethanolamine, glycerol, tween, methyl benzoate and potassium sorbate to obtain water phase, respectively heating the oil phase and water phase to 85deg.C in water, slowly pouring the oil phase into the water phase, stirring to obtain cream with milky yellow and semisolid, cooling the cream to 55deg.C, adding Margarita powder and Lithargyrum powder, and stirring for 2 hr until the cream is condensed.
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109620909A (en) * 2018-10-08 2019-04-16 车丽萍 Chinese medicine composition, Chinese medicine eye mask and its preparation and application
CN111450170A (en) * 2019-01-18 2020-07-28 任玉娟 Eyesight-improving and eye-protecting composition for children and application and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109620909A (en) * 2018-10-08 2019-04-16 车丽萍 Chinese medicine composition, Chinese medicine eye mask and its preparation and application
CN111450170A (en) * 2019-01-18 2020-07-28 任玉娟 Eyesight-improving and eye-protecting composition for children and application and preparation method thereof

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