CN116087539A

CN116087539A - Sample analyzer and control method thereof

Info

Publication number: CN116087539A
Application number: CN202111308840.0A
Authority: CN
Inventors: 李冬冬; 李爱博; 李鑫
Original assignee: Beijing Mindray Medical Instrument Co ltd; Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Beijing Mindray Medical Instrument Co ltd; Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2021-11-05
Filing date: 2021-11-05
Publication date: 2023-05-09

Abstract

The invention is suitable for the field of sample analysis equipment, and discloses a sample analyzer and a control method of the sample analyzer, wherein the sample analyzer comprises an analyzer execution main body and a controller; the analyzer execution body comprises a sample adding device and a sample detecting device: the sample adding device comprises a sample needle with a puncture function, wherein the sample needle is used for sucking and dispensing diluent and is used for puncturing a cap of the sample container to suck and dispense samples; the controller is configured to control the sample loading device to sequentially perform the following actions: firstly, controlling a sample needle to puncture a cap of a sample container to enter the sample container to suck a sample and store the sample in a sample adding device; then controlling the sample needle to absorb the diluent from the diluent device and store the diluent in the sample adding device; the sample needle is then controlled to dispense the diluent and at least a portion of the sample stored in the sample application device to the reaction vessel. The invention reduces the cost and the volume of the sample analyzer and is beneficial to improving the sample detection efficiency of the sample analyzer.

Description

Sample analyzer and control method thereof

Technical Field

The present invention relates to the field of sample analysis devices, and in particular, to a sample analyzer and a control method of the sample analyzer.

Background

A sample analyzer is provided in the conventional art, which performs sample detection items including sample detection items requiring dilution and sample detection items not requiring dilution. When a sample is added, the sample detection item requiring the diluent is required to collect the sample and the diluent respectively and to be dispensed into the reaction container. In the conventional art, the collection and dispensing of the sample and the diluent are separately performed by using two different sample needles, namely: the sample adding device is provided with two sample adding devices, each sample adding device comprises a sample needle, one sample needle is used for collecting and dispensing samples, and the other sample needle is used for collecting and dispensing diluent. This conventional solution has the following disadvantages in the specific application:

1) The provision of two sample application devices for one sample analyzer may lead to a complicated structure of the sample analyzer and may lead to an increase in cost and volume of the sample analyzer. In addition, since the sample application device for collecting and dispensing the diluent is in an idle state when executing the sample detection item that does not require the diluent, there is a serious problem of resource idle in use of the sample analyzer.

2) In order to avoid contamination, the sample container is generally provided with a rubber cap or a rubber stopper, and when the sample needle collects a sample from the sample container, the sample needle is required to pierce the cap of the sample container and extend into the sample container to suck the sample. And a sample in a sample container typically requires multiple sample testing items. In the prior art, the sampling of each sample detection item needs the sample needle to puncture the cap of the sample container once to suck the sample of one sample detection item, so that the sample needle needs to repeatedly puncture the cap of the sample container when sucking multiple samples of one sample container, and the cap made of rubber material is easy to generate scraps after repeated puncture, thereby easily causing the problem that the scraps block the sample needle. And the puncture times of the sample needle are too high, so that the abrasion and deformation risks of the sample needle are increased, and the service life of the sample needle is shortened.

Disclosure of Invention

A first object of the present invention is to provide a sample analyzer, which aims to solve the technical problems of complex structure, high cost and large volume of the sample analyzer caused by the fact that two sample needles are provided in the conventional technology, one sample needle is used for sucking and dispensing a sample, and the other sample needle is used for sucking and dispensing a diluent.

In order to achieve the above purpose, the invention provides the following scheme: a sample analyzer comprising an analyzer execution body and a controller;

the analyzer execution body comprises a sample device, a diluent device, a sample adding device, a reagent bearing device, a reagent dispensing device and a sample detection device:

the sample device is used for carrying a sample container loaded with a sample;

the diluent device is used for supplying diluent;

the sample adding device comprises a sample needle with a puncture function, wherein the sample needle is used for sucking and dispensing the diluent and is used for puncturing a cover cap of the sample container to suck the sample and dispense the sample;

the reagent carrying device is used for carrying a reagent container loaded with a reagent;

the reagent dispensing device is used for sucking reagent from the reagent container and dispensing the sucked reagent into the reaction container;

the sample detection device is used for performing sample detection on a first type of sample made of a sample, a diluent and a reagent in the reaction container, and is used for performing sample detection on a second type of sample made of the sample and the reagent in the reaction container;

the controller is used for controlling the analyzer execution body to execute sample detection items, wherein the sample detection items comprise diluted sample detection items requiring dilution and undiluted sample detection items not requiring dilution;

The controller is configured to control the loading device to sequentially perform the following actions:

firstly, controlling the sample needle to puncture a cap of the sample container into the sample container to suck the sample stored in the sample adding device;

then controlling the sample needle to absorb the diluent from the diluent device and store the diluent in the sample adding device;

controlling the sample needle to dispense the diluent and at least part of the sample stored in the sample adding device to the reaction container;

and the controller is further configured to: and controlling the completion time of each diluted sample detection item and the completion time of each undiluted sample detection item to be the same, and configuring the interval time of any two adjacent sample detection items to be the same.

A second object of the present invention is to provide a sample analyzer including an analyzer execution body and a controller;

the sample device is used for carrying a sample container loaded with a sample;

the diluent device is used for supplying diluent;

The sample adding device comprises a sample needle, wherein the sample needle is used for sucking and dispensing diluent and is used for sucking and dispensing samples;

firstly controlling the sample needle to suck a sample from the sample container and store the sample in the sample adding device;

And controlling the sample needle to dispense the diluent and at least part of the sample stored in the sample application device to the reaction container.

A third object of the present invention is to provide a control method of a sample analyzer, comprising:

controlling a sample needle with a puncturing function to puncture a cap of the sample container into the sample container to suck the sample and store the sample in the sample adding device;

controlling the sample needle to absorb the diluent from the diluent device and store the diluent in the sample adding device;

controlling the sample needle to dispense the diluent and at least a portion of the sample stored in the sample application device to the reaction vessel;

and the completion time of each diluted sample detection item and the completion time of each undiluted sample detection item are controlled to be the same, and the interval time of any two adjacent sample detection items is configured to be the same.

A fourth object of the present invention is to provide a control method of a sample analyzer, comprising:

controlling a sample sucking device to suck a sample from a sample container and store the sample in a sample feeding device;

controlling the sample needle to dispense the diluent and at least a portion of the sample stored in the sample application device to the reaction vessel.

According to the sample analyzer and the control method of the sample analyzer, the sample needle is used for sucking and dispensing the sample and the diluent at the same time, so that the structure of the sample analyzer is effectively simplified, the cost and the volume of the sample analyzer are reduced, and the phenomenon of idle and waste of resources is avoided. In addition, the invention firstly controls the sample needle to suck the sample from the sample container and store the sample in the sample adding device, and then controls the sample needle to suck the diluent from the diluent device and store the diluent in the sample adding device; and then controlling the sample needle to dispense the diluent and at least part of the sample stored in the sample adding device to the reaction container, so that the diluent and the sample in the diluted sample detection project can be dispensed in the same dispensing action, the dispensing action times of the sample needle can be reduced, the sample detection efficiency of the sample analyzer can be improved, and the sample detection flux of the sample analyzer can be improved.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to the structures shown in these drawings without inventive effort for a person skilled in the art.

Fig. 1 is a flow chart of a sampling and sample dividing control method of a sample analyzer according to an embodiment of the present invention;

FIG. 2 is a schematic diagram of the composition of a sample analyzer according to an embodiment of the present invention;

FIG. 3 is a schematic diagram of distribution positions of a sample loading device, a diluent device, a reaction vessel conveying assembly, a second cleaning device, a sampling position and a sample loading position according to an embodiment of the present invention;

FIG. 4 is a schematic diagram showing the connection of the sample adding device, the first cleaning device, the second cleaning device and the waste liquid tank according to the embodiment of the present invention;

FIG. 5 is a schematic view showing a state change of a sample needle provided in an embodiment of the present invention, wherein the sample needle has an air-to-spitting portion from a sample suction port and is wiped by a first cleaning device;

FIG. 6 is a schematic view showing a state change of a sample needle provided in an embodiment of the present invention, wherein the sample needle has a sample overflow from a sample suction port to a sample discharge port and is wiped by a first cleaning device;

FIG. 7 is a schematic diagram of the sample, the isolation gas column and the diluent stored in the sample needle according to the embodiment of the present invention.

Reference numerals illustrate: 100. a sample analyzer; 110. an analyzer execution body; 111. a sample device; 1111. sampling bits; 112. a diluent device; 113. a sample adding device; 1131. a sample needle; 1132. a sample suction pipeline; 1133. a motion driving device; 1134. a sampling syringe; 114. a reagent carrying device; 115. a reagent dispensing device; 116. a sample detection device; 117. an interfering substance detection device; 118. a reaction vessel feeding device; 1181. a sample adding position; 119. an incubation device; 101. a reaction vessel transport assembly; 1011. a clamping jaw; 102. a first cleaning device; 103. a second cleaning device; 1031. a cleaning pool; 1032. a cleaning liquid power device; 1033. a cleaning liquid supply device; 104. a waste liquid pool; 105. a cleaning device; 120. a controller; 130. a display device; 200. a sample; 300. air; 400. and (3) diluting the liquid.

Detailed Description

The following description of the embodiments of the present invention will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

It should be noted that all directional indications (such as up, down, left, right, front, and rear … …) in the embodiments of the present invention are merely used to explain the relative positional relationship between the components, the movement condition, etc. in a specific posture, and if the specific posture is changed, the directional indication is changed accordingly.

It will also be understood that when an element is referred to as being "mounted" or "disposed" on another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or be indirectly connected to the other element through intervening elements.

Furthermore, the description of "first," "second," etc. in this disclosure is for descriptive purposes only and is not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In addition, the technical solutions of the embodiments may be combined with each other, but it is necessary to base that the technical solutions can be realized by those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should be considered to be absent and not within the scope of protection claimed in the present invention.

As shown in fig. 1 to 7, a sample analyzer 100 according to an embodiment of the present invention includes an analyzer executing body 110 and a controller 120. The controller 120 is for controlling the analyzer execution body 110 to execute sample detection items including diluted sample detection items requiring the addition of the diluent 400 and undiluted sample detection items not requiring the addition of the diluent 400.

As one embodiment, the analyzer execution body 110 includes a sample device 111, a diluent device 112, a sample application device 113, a reagent carrying device 114, a reagent dispensing device 115, and a sample detection device 116. The sample device 111 is for carrying a sample container loaded with a sample 200; the diluent device 112 is used for supplying a diluent 400; the sample application device 113 includes a sample needle 1131, the sample needle 1131 for aspirating and dispensing the diluent 400 and for aspirating and dispensing the sample 200; the reagent carrying apparatus 114 is used for carrying a reagent container loaded with a reagent; the reagent dispensing device 115 is used to aspirate a reagent from a reagent container and dispense the aspirated reagent into a reaction container; the sample detection device 116 is used for performing detection on a first type of sample made of the sample 200, the diluent 400 and the reagent in the reaction vessel, and for performing detection on a second type of sample made of the sample 200 and the reagent in the reaction vessel. In this embodiment, one sample needle 1131 is used for sucking and dispensing the sample 200 and the diluent 400 at the same time, that is, the sample 200 and the diluent 400 are sucked and dispensed by one sample needle 1131, so that the structure of the sample analyzer 100 is effectively simplified, and the cost and the volume of the sample analyzer 100 are reduced.

As an embodiment: the controller 120 is configured to control the loading device 113 to sequentially perform the following actions: firstly, the sample needle 1131 is controlled to suck the sample 200 from the sample container and store the sample in the sample adding device 113; then, the sample needle 1131 is controlled to draw the diluent 400 from the diluent device 112 and store the diluent 400 in the sample adding device 113; the sample needle 1131 is then controlled to dispense the diluent 400 and at least a portion of the sample 200 stored in the sample application device 113 to the reaction vessel. In this embodiment, the dispensing of the diluent 400 and the sample 200 in the diluted sample detection item can be completed in the same dispensing operation, so that the number of dispensing operations of the sample needle 1131 can be reduced, and further the sample 200 detection efficiency of the sample analyzer 100 can be improved.

As one embodiment, the sample device 111 includes a sample injector for automatically transporting the sample container to a designated location. The sample injector has a sampling position 1111, a loading position and an unloading position, wherein the sampling position 1111 is used for the sample adding device 113 to draw the sample 200 from the sample container, the loading position is used for a user or other operators to place the sample container loaded with the sample 200 on the sample injector, and the unloading position is used for the user or other operators to take the sample container with the sample 200 collected from the sample injector. The design of the sample injector can be beneficial to realizing the mass detection of the sample 200, thereby being beneficial to improving the detection efficiency of the blood sample 200 and reducing the labor cost.

As one embodiment, the sample injector includes a loading area, an unloading area, a buffer area, and a transport mechanism, wherein the sampling bit 1111 is formed in the buffer area, the loading bit is formed in the loading area, the unloading bit is formed in the unloading area, and the loading area is used for placing a sample carrier loaded with the sample 200. The transport mechanism includes a first drive mechanism for driving the sample carrier to be transported from the loading zone to the buffer zone, a second drive mechanism for driving the sample carrier to move along the buffer zone, and a third drive mechanism for driving the sample carrier to be transported from the buffer zone to the unloading zone. The sample carrier is provided with a container mounting slot for insertion and positioning of a sample container. The working principle of the sample injector is as follows; firstly, placing a sample carrier loaded with a plurality of sample containers in a loading area, and pushing the sample carrier to a buffer area by a first driving mechanism; the second driving mechanism drives the sample bearing frame to transversely feed along the buffer area, in the transverse feeding process, the sample injector sequentially detects whether a cap exists on the sample container or not and rotates to scan codes, then the sample container moves to a sampling position 1111, and a sample suction device 113 sucks samples from the sample container at the sampling position 1111; after the sample is sucked, the sample carrier continues to transversely feed to the tail end of the buffer zone, and finally the third driving mechanism conveys the sample carrier from the buffer zone to the unloading zone.

As an embodiment, the sample injector is mainly used for carrying and conveying a sample container with a cap at the top, and the sampling position 1111 formed on the sample injector is a puncture sampling position 1111. The sample container is sealed by the cap, so that the sample container can be transported in batches, the adverse phenomena of sprinkling and splashing the blood sample 200 and even dumping the blood sample in the transporting process of the sample container can be avoided, and the long-term exposed placement of the blood sample 200 can be prevented from being polluted and spoiled.

As an embodiment, the sample device 111 further comprises a manual sample introduction cartridge. An open sampling bit 1111 is formed on the manual sample injection bin. The manual sampling bin is used for a user or other operators to manually place the sample container at the open sampling position 1111, in this embodiment, a puncture sampling position 1111 is formed on the sampler, and the open sampling position 1111 is formed on the manual sampling bin, so that the user or other operators can conveniently perform the queue insertion detection on the individual samples 200 according to actual conditions, so as to meet the rapid detection requirement of the emergency samples 200, and the manual sampling bin is preferably suitable for placing the sample container without a cap to bear the top opening. In this embodiment, the sample device 111 includes both a sample injector and a manual sample injection bin, however, in specific applications, the arrangement of the sample device 111 is not limited thereto, and for example, in alternative embodiments, the sample device 111 may include only a sample injector or only a manual sample injection bin.

In one embodiment, the diluent means 112 is a diluent 400 kit provided on the reagent carrier means 114. Of course, in particular applications, the diluent apparatus 112 may be other containers for the apparatus diluent 400, and the diluent apparatus 112 may be provided independently of the reagent carrying apparatus 114.

As one embodiment, the sample needle 1131 is a puncture needle having a puncture function, and the sample needle 1131 is used for sucking and dispensing the diluent 400, and is used for puncturing a cap of the sample container to suck the sample 200 and dispense the sample 200. The controller 120 is configured to: the sample needle 1131 can be controlled to pierce a capped sample container and draw the sample 200 from the sample container into the sample application device 113, and the sample needle 1131 can be controlled to draw the sample 200 from an uncapped sample container into the sample application device 113. The sample needle 1131 has a puncturing function specifically to: sample needle 1131 may pierce the cap of the sample container into the sample container. The sample needle 1131 has a piercing function that facilitates the sample analyzer 100 to either aspirate the sample 200 from a capped sample container or aspirate the sample 200 from a non-capped sample container. Of course, in a specific application, as an alternative embodiment, the sample needle 1131 may be provided as a non-puncturing needle without puncturing function, and the controller 120 is configured to: the sample needle 1131 can be controlled to aspirate the sample 200 from the uncapped sample container and store it in the sample application device 113.

As an embodiment, the sample application device 113 further includes a sampling tube 1132, a motion driving device 1133, and a sampling syringe 1134, where the sampling tube 1132 is connected to the sample needle 1131 and the sampling syringe 1134, and the sampling syringe 1134 is used to provide driving force for the sample needle 1131 to suck and discharge fluid. The sample needle 1131 is mounted on a motion drive 1133, and the motion drive 1133 can drive the sample needle 1131 to perform spatial motion so as to enable the sample needle 1131 to move to different stations, such as a standby station, a sampling station 1111, a diluent 400 station, a sample adding station 1181, a cleaning station, and the like.

As one embodiment, the motion driving device 1133 includes a rotation swing arm mechanism for driving the sample needle 1131 to perform a lifting motion, and a lifting mechanism for driving the sample needle 1131 to perform a rotation motion. The sampling sites 1111, the two sample addition sites 1181, and the pipetting sites of the diluent apparatus 112 are spaced apart on the rotational trajectory of the sample needle 1131. Of course, in a specific application, the manner of disposing the motion driving device 1133 is not limited thereto, and for example, the motion driving device 1133 may be a device capable of driving the sample needle 1131 to perform a spatial two-dimensional linear motion or a three-dimensional linear motion.

As an embodiment, the reagent carrying apparatus 114 is used for carrying reagent containers loaded with reagents. The reagent dispensing device 115 is used to aspirate a reagent from a reagent container and dispense the aspirated reagent into a reaction container. The reagent carrier 114 may in particular be disc-shaped, which may be used for carrying a plurality of reagent containers.

As one embodiment, the sample testing device 116 is used to perform tests on a first type of sample in the reaction vessel made of the sample 200, the diluent 400, and the reagent, and to perform tests on a second type of sample in the reaction vessel made of the sample 200 and the reagent. The sample detection device 116 includes at least one first illumination means for emitting light toward each reaction vessel loaded with a sample, and a plurality of first light receiving means for receiving light information generated after the light is transmitted, reflected, or scattered by the sample, respectively.

As an embodiment, the sample analyzer 100 further includes an interferent detection device 117, where the interferent detection device 117 is configured to perform interferent detection on the sample 200 to detect the quality of the sample 200, so as to facilitate improving the accuracy of the detection of the sample 200. The sample needle 1131 is also used to aspirate and dispense the sample 200 for detection of the interferent. The controller 120 is also configured to control the interferent detection device 117 to perform interferent detection. When an interfering object exists in the sample 200, interference can be caused to the detection result; for example, when there are interferents such as hemoglobin, bilirubin, and chyle in the sample 200, the interferents may interfere with the detection result of the sample 200 because they absorb light strongly. Hemoglobin, bilirubin, and chyle may be collectively referred to as HIL interference, where H refers to hemoglobin, I refers to bilirubin, and L refers to chyle.

In one embodiment, the interferent detection device 117 includes an interferent detection vessel and an interferent detection member for performing interferent detection on a third type of sample within the interferent detection vessel made up of a sample 200 or a mixture of a sample 200 and a diluent 400.

As an embodiment, the interfering substance detecting device 117 may share a first illumination means with the sample detecting device 116, the interfering substance detecting means including a second light receiving means; alternatively, the interfering substance detecting device 117 may not share the first illumination means with the sample detecting device 116, that is, the interfering substance detecting means may include the second illumination means and the second light receiving means independently of the sample detecting device 116.

As one embodiment, the sample analyzer 100 further includes a cleaning device 105, and the cleaning device 105 is configured to clean the sample needle 1131.

As one embodiment, the cleaning device 105 comprises a first cleaning device 102, the first cleaning device 102 being primarily used for cleaning the outer wall of the sample needle 1131. The first cleaning device 102 is a swab, the swab is mounted on a vertical guide rail of the sample adding device 113, the swab is provided with a cleaning hole for the sample needle 1131 to move up and down, and when the sample needle 1131 moves up and down in the cleaning hole, the swab can wipe and clean the outer wall of the sample needle 1131. In this embodiment, the swab is mounted on the sample loading device 113, so that the structure is compact, and after the sample needle 1131 is sucked, the sample needle 1131 can be lifted up to clean the sample needle 1131 in the first cleaning device 102, which is beneficial to saving time.

As one embodiment, when the sample needle 1131 is a puncture needle and the sample container has a cap closure, the controller 120 is further configured to: after the sample needle 1131 is controlled to draw the sample 200 from the sample container with the cap and the sample needle 1131 is controlled to be drawn out from the sample container, the sample needle 1131 is controlled to discharge part of the sample 200 to the first cleaning device 102; the first cleaning device 102 is used to clean the sample 200 discharged from the sample needle 1131. Because of the imbalance between the pressure within the capped sample container and the pressure of the external environment, when the sample needle 1131 aspirates the sample 200 from the cap of the sample container (i.e., the sample needle 1131 rises to disengage the cap), the aspiration port of the sample needle 1131 may spill a portion of the sample 200 or the aspiration port may aspirate a portion of the air 300, and the amount of air 300 that is aspirated into the sample needle 1131 or the spilled sample 200 may be indeterminate, which, if not processed, may affect the accuracy of dispensing the sample 200. In this embodiment, after the sample needle 1131 is withdrawn from the sample container, a part of the sample 200 is discharged to the first cleaning device 102 by controlling the sample needle 1131; the sample 200 ejected by the sample needle 1131 is washed by the first washing device 102, so that the sample sucking opening of the sample needle 1131 can be filled with the sample 200, and the outer wall of the sample needle 1131 can be free from sample 200 residues, so that the accuracy of dispensing the sample 200 is fully ensured.

As an embodiment, the cleaning device 105 further includes a second cleaning device 103, where the second cleaning device 103 primarily cleans the inner wall and the outer wall of the sample needle 1131 with a cleaning solution to eliminate the sample 200 and/or the diluent 400 remaining in the sample needle 1131. The second cleaning device 103 includes a cleaning reservoir 1031, a cleaning liquid supply device 1033, and a cleaning liquid power device 1032, the cleaning reservoir 1031 being connected to the cleaning liquid supply device 1033 through a cleaning line, the cleaning line being provided with the cleaning liquid power device 1032, the cleaning liquid power device 1032 being configured to drive the cleaning liquid to be transported from the cleaning liquid supply device 1033 to the cleaning reservoir 1031. The cleaning fluid power device 1032 may be a syringe or a liquid pump.

As an embodiment, the sample analyzer 100 further includes a waste liquid tank 104, and the first cleaning device 102 and the cleaning tank 1031 are connected to the waste liquid tank 104 by pipes, respectively. The waste liquid tank 104 is used to collect waste liquid discharged from the first cleaning device 102 and the cleaning tank 1031.

As an embodiment, the sample analyzer 100 further comprises an incubation device 119 and a reaction vessel transport assembly 101, the incubation device 119 being used for incubating the sample 200 or the sample 200 with the diluent 400 or the sample 200 with the reagent or the sample 200 with the diluent 400 in the reaction vessel. The reaction vessel transport assembly 101 is used to transport reaction vessels from the sample carrier device to the incubation device 119 and to move reaction vessels from the incubation device 119 to the sample detection device 116.

As one embodiment, the reactor vessel transport assembly 101 includes at least one jaw 1011 and a power means for driving each jaw 1011 to move. The clamping jaw 1011 is used for clamping the reaction vessel. Of course, in particular applications, the arrangement of the reactor vessel transport assembly 101 is not limited thereto, and for example, in an alternative embodiment, the reactor vessel transport assembly 101 may also include a conveyor track.

As an embodiment, the sample analyzer 100 further includes a cup-throwing device for throwing out the reaction container in which the detection of the sample 200 is completed, so as to implement recovery of the reaction container. When the reaction vessel receives the detection by the sample detection device 116, it is located at a detection site provided in the sample detection device 116. In order to ensure continuous operation of the sample testing device 116, the reaction vessel after each test is moved out of the test site so that the reaction vessel of the subsequent sample test item can be loaded onto the test site to be tested. The cup throwing device can be a part of the reaction vessel conveying assembly 101, namely, part of the mechanism of the reaction vessel conveying assembly 101 can be reused for the cup throwing device, so that the structure is simplified and the cost is reduced; of course, in alternative embodiments, the beaker device may also be a device separate from the reactor vessel transport assembly 101.

As one embodiment, the sample analyzer 100 further includes a display device 130, the display device 130 being electrically connected to the controller 120. The display device 130 may be a touch screen having both a display function and a touch function, or may be a display screen having a display function alone.

As an embodiment, the sample analyzer 100 further comprises a reaction vessel loading device 118, wherein the reaction vessel loading device 118 is provided with a sample loading position 1181, and the sample loading position 1181 is used for receiving the sample 200 and/or the diluent 400 by the reaction vessel.

As one embodiment, the controller 120 is configured to: controlling the sample needle 1131 to draw the sample 200 from the sample container and stored in the sample application device 113 at a time, wherein the sample 200 is greater than or equal to the sample 200 required by at least two sample detection items; and the sample needle 1131 is controlled to dispense the samples 200 stored in the sample loading device 113 to at least two reaction containers in accordance with the required amounts of the samples 200 for the respective sample detection items. In this embodiment, the amount of the sample 200 sucked by the sample needle 1131 from the sample container at a time is greater than or equal to the sample 200 required amount of at least two sample detection items, so that the number of times that the sample needle 1131 sucks the sample 200 from one sample container can be effectively reduced, thereby facilitating the reduction of the number of actions of the sample needle 1131, and thus facilitating the improvement of the working efficiency of the sample analyzer 100. In addition, when the sample needle 1131 is a puncture needle and the sample container is provided with a cap for sealing, in the embodiment, the number of times that the sample needle 1131 punctures the sample container can be reduced, so that on one hand, the risk that the sample needle 1131 is blocked by scraps is reduced, and on the other hand, the abrasion and deformation of the sample needle 1131 are reduced, and further, the service life of the sample needle 1131 is guaranteed; yet another aspect facilitates improving the operational efficiency of the sample analyzer 100.

As one embodiment, the controller 120 is configured to: the amount of sample 200 that is drawn from the sample container by the sample needle 1131 and stored in the sample application device 113 is controlled to be greater than or equal to the required amount of sample 200 for performing all sample testing items required for the sample 200 in the sample container. In this embodiment, the sampling of all sample detection items to be performed by the sample 200 in one sample container only needs to be performed once by the sample needle 1131, so that the number of times of sample sucking by the sample needle 1131 is greatly reduced. In addition, when the sample needle 1131 is a puncture needle and the sample container has a cap closure, the number of times the sample needle 1131 punctures the sample container can be minimized in the present embodiment.

As one embodiment, the controller 120 is further configured to control the sample needle 1131 to dispense the aspirated portion of the sample 200 to the interferent detection container, and the controller 120 is further configured to: the amount of the sample 200 sucked from the sample container by the sample needle 1131 and stored in the sample loading device 113 is controlled to be greater than or equal to the sum of the required amount of the sample 200 for performing all sample detection items of the sample 200 in the sample container and the required amount of the sample 200 for detecting the interfering substance. In this embodiment, the sample 200 of all sample detection items of the sample 200 is sucked and sucked with the sample 200 of the interfering object detection item together for one time, so that the puncture times of the sample needle 1131 can be reduced to the greatest extent, and the sample feeding component and the independent sample sucking flow are not required to be separately arranged for sucking and dispensing the sample 200 of the interfering object detection, thereby facilitating the simplification of the structure of the sample analyzer 100 and the improvement of the working efficiency of the sample analyzer 100.

As one embodiment, the controller 120 is further configured to: after controlling the sample needle 1131 to draw the sample 200 from the sample container into the sample application device 113 and before controlling the sample needle 1131 to draw the diluent 400 from the diluent device 112 into the sample application device 113, controlling the sample needle 1131 to draw air 300 to form a column of isolation air within the sample needle 1131; the controller 120 is further configured to: the sample needle 1131 is controlled to dispense the diluent 400, the separation gas column, and at least a portion of the sample 200 stored in the sample application device 113 to the reaction vessel. The adoption of the isolation air column can be beneficial to improving the accuracy of the split injection of the sample 200. Specifically, the diluent device 112 for carrying the diluent 400 is an open container, the diluent 400 is sucked normally under the ambient pressure, so that the problem of inaccurate liquid suction caused by unbalanced pressure inside and outside the diluent device 112 is avoided, the volume of the diluent 400 is accurate, and the volume of the isolated air column between the diluent 400 and the sample 200 is also determined, so that the dispensing of the sample 200 and the diluent 400 according to the method in the present embodiment can ensure that the volumes of the sample 200 and the diluent 400 are both accurate.

As one embodiment, the controller 120 is further configured to: before controlling the sample needle 1131 to draw the diluent 400 from the diluent device 112, determining whether the diluent 400 is required to be added to the sample detection item to be sampled; if so, the sample needle 1131 is controlled to draw the diluent 400 required by one sample detection item from the diluent device 112, and then the sample needle 1131 is controlled to dispense the drawn diluent 400 and at least part of the sample 200 into the reaction vessel; if not, the sample needle 1131 is controlled to dispense at least a portion of the aspirated sample 200 into the reaction vessel. In this embodiment, the sample loading operation of the diluted sample detection item and the undiluted sample detection item can be automatically realized without sorting the sample detection items to be executed by the sample 200, and the sample loading efficiency is high.

Specifically, the controller 120 is electrically connected to the sample device 111, the reagent carrying device 114, the sample adding device 113, the reagent dispensing device 115, the incubation device 119, the sample detecting device 116, the interferent detecting device 117, the reaction container conveying assembly 101, the reaction container feeding device 118, the display device 130 and the cup throwing device, respectively, and the controller 120 is configured to allocate the cooperation between the devices to complete the detection operation of each sample 200.

As one embodiment, the controller 120 is further configured to: and controlling the completion time of each diluted sample detection item and the completion time of each undiluted sample detection item to be the same. Because the steps required to be performed for different kinds of sample detection items in the sample analyzer 100 are substantially the same, the operations of loading the sample 200, incubating, loading the reagent, detecting the sample 200, and polishing the cup are sequentially performed, and resources of the sample analyzer 100, such as the sample loading device 113, the reagent dispensing device 115, the detecting device, and the polishing cup device, that require actual movements or operations to be performed, are limited in configuration due to cost. Under limited configuration conditions, the sample analyzer 100 may cause a conflict of related resources if detecting each sample detection item in which the detection completion time of the sample 200 is different. For example, the time length of completing the sample detection item performed in advance is longer, and the time length of completing the sample detection item performed in later is shorter, and the starting point time of the unfolding detection operation are different, but the ending point time of the ending detection operation may coincide. The reagent dispensing device 115 is in the case where it is necessary to add reagents to the sample detection items previously developed and to add reagents to the sample detection items later developed at the same time or within a short period of time, respectively; alternatively, the sample detection device 116 needs to perform the detection operation of two sample detection items at the same time or within a short period of time. In this embodiment, after the completion time periods of the different types of sample detection items are unified, resources can be sequentially allocated between the sample detection items, for example, the sample adding device 113 sequentially performs sample adding operation on the sample detection items, the incubation device 119 sequentially completes incubation operation of the reaction containers, the reagent dispensing device 115 sequentially dispenses reagents on the sample detection items, the sample detecting device 116 sequentially detects the sample detection items, and the cup throwing device sequentially throws out the reaction containers after detection. Therefore, each sample detection item developed in real time in the sample analyzer 100 provided in this embodiment does not occupy the same resource configuration at the same time, which is beneficial for the controller 120 to coordinate the cooperative work between the devices, so as to ensure that each sample detection item can complete the detection work within a preset uniform duration, thereby obtaining a constant sample 200 detection speed and sample 200 detection flux. It can be appreciated that in the present embodiment, the sample 200 detection flux of the sample analyzer 100 is obtained by simultaneously detecting a plurality of different sample detection items, which is closer to the requirement of the usage scenario.

As an embodiment, the operation flow of each sample detection item in the sample analyzer 100 is mainly completed based on the sequential operation sequence of the sample adding device 113, the incubation device 119, the reagent dispensing device 115, the sample detection device 116 and the cup throwing device, and the unified operation sequence enables the controller 120 to sequentially complete the resource allocation work of each device resource among different sample detection items, so as to ensure that each sample detection item in the sample analyzer 100 is sequentially performed.

As one embodiment, the completion time period of each sample detection item is: from the start time of the sample loading timing performed by the sample loading device 113 to the end time of the cup loading timing performed by the cup loading device. In an actual operation scenario, the starting timing time and the ending timing time of the sample detection item in the sample analyzer 100 may be set arbitrarily according to considerations such as convenience, identifiability, and consistency of timing. As long as the starting timing time is uniform for all sample detection items and the end timing time is uniform, the completion time of all sample detection items can be ensured to be consistent.

As one embodiment, the controller 120 is further configured to: the interval time of any two adjacent sample detection items is configured to be the same, so that the controller 120 is beneficial to controlling each device to start executing the operation of the next sample detection item within the same interval time, thereby being beneficial to realizing the orderly configuration of resources and avoiding the conflict phenomenon of the resource configuration.

As one embodiment, the sample analyzer 100 is a coagulation analyzer, and the reagent carrier 114 is configured to carry a first reagent container loaded with a first reagent and a second reagent container loaded with a second reagent; the first reagent is a mixed reagent and the second reagent is a trigger reagent. The reagent dispensing device 115 includes a first reagent dispensing mechanism including a first reagent needle for sucking a first reagent from a first reagent container and dispensing the sucked first reagent into a reaction container, and a second reagent dispensing mechanism; the second reagent dispensing mechanism comprises two second reagent needles which move independently of each other, and the two second reagent needles are used for alternately sucking the second reagent from the second reagent container and dispensing the sucked second reagent into the reaction container. The incubation means 119 is used for incubating the sample 200 or the sample 200 with a first reagent in a reaction vessel. The sample detection items comprise a double-reagent detection item and a single-reagent detection item; in the dual reagent test item, the reaction vessel requires the addition of a mixing reagent and a triggering reagent. In single reagent detection projects, the reaction vessel only needs to be added with a trigger reagent. Of course, in particular applications, the sample analyzer 100 may be other types of analyzers.

Sample detection items that sample analyzer 100 may accomplish include, but are not limited to, as an embodiment: plasma prothrombin Project (PT), activated partial thromboplastin project (APTT), fibrinogen project (FIB), thrombin project (TT), antithrombin iii project (AT iii), and the like. Wherein the activated partial thromboplastin (APTT) is typically a two-reagent test item, requiring the addition of a mixed reagent during incubation to prepare a sample.

The present embodiment also provides a control method of the sample analyzer 100, which includes the following steps:

s10, controlling a sample needle 1131 to draw a sample 200 from a sample container and store the sample in the sample adding device 113;

s20, controlling the sample needle 1131 to suck the diluent 400 from the diluent device 112 and store the diluent 400 in the sample adding device 113;

s30, the sample needle 1131 is controlled to dispense the diluent 400 and at least a part of the sample 200 stored in the sample loading device 113 into the reaction container.

As one embodiment, step S10 specifically includes: a sample needle 1131 with a puncturing function is controlled to puncture the cap of the sample container, and the sample 200 is sucked into the sample container and stored in the sample loading device 113. In this embodiment, the sample needle 1131 has a puncture function, and the sample container has a cap closure.

In one embodiment, in step S10, the sample needle 1131 is controlled to draw the sample 200 from the sample container in an amount greater than or equal to the sample 200 requirement of at least two sample test items in the sample application device 113; controlling the sample needle 1131 to dispense the diluent 400 and at least a portion of the sample 200 stored in the sample application device 113 to the reaction vessel includes: the sample needle 1131 is controlled to dispense the samples 200 stored in the sample application device 113 to at least two reaction containers in accordance with the required amounts of the samples 200 for the respective sample detection items.

In one embodiment, in step S10, the amount of sample 200 stored in the sample loading device 113 is controlled by the sample needle 1131 to draw the sample 200 from the sample container, which is greater than or equal to the required amount of sample 200 for performing all sample detection items required for the sample 200 in the sample container.

In one embodiment, in step S10, the sample needle 1131 is controlled to draw the sample 200 from the sample container and store it in the sample loading device 113, which is greater than or equal to the sum of the sample 200 requirement for performing all sample detection items on the sample 200 in the sample container and the sample 200 requirement for detecting the interfering substance; the control method further comprises the following steps: the sample needle 1131 is controlled to dispense the sample 200 stored in the sample application device 113 to the interference detection container.

In one embodiment, in step S10, the control of the sample needle 1131 to aspirate the sample 200 from the sample container and store it in the sample application device 113 includes: controlling the sample needle 1131 to pierce the cap of the sample container and draw the sample 200 from the sample container into the sample application device 113; controlling withdrawal of the sample needle 1131 from the sample container; the sample needle 1131 is controlled to eject a portion of the sample 200 to the first cleaning device 102.

In one embodiment, the control method further comprises, after controlling the sample needle 1131 to draw the sample 200 from the sample container and store it in the sample application device 113, and before controlling the sample needle 1131 to draw the diluent 400 from the diluent device 112 and store it in the sample application device 113: sample needle 1131 is controlled to draw air 300 to form a column of insulating air within sample needle 1131. In step S30, the control sample needle 1131 dispenses the diluent 400 and at least part of the sample 200 stored in the sample application device 113 into the reaction container, including: the sample needle 1131 is controlled to dispense the diluent 400, the separation gas column, and at least a portion of the sample 200 stored in the sample application device 113 to the reaction vessel.

As one embodiment, the sample separation control method further includes, before controlling the sample needle 1131 to draw the diluent 400 from the diluent device 112: judging whether a sample detection item to be loaded needs to be loaded with the diluent 400 or not; if so, controlling the sample needle 1131 to draw the diluent 400 required by the sample detection item from the diluent device 112 to be stored in the sample adding device 113, and controlling the sample needle 1131 to dispense the diluent 400 and at least part of the sample 200 stored in the sample adding device 113 to the reaction vessel; if not, the sample needle 1131 is controlled to dispense at least a portion of the aspirated sample 200 into the reaction vessel.

As one embodiment, the control method of the sample analyzer 100 further includes: and controlling the completion time of each diluted sample detection item and the completion time of each undiluted sample detection item to be the same.

As one embodiment, the control method of the sample analyzer 100 further includes: the interval time of any two adjacent sample detection items is configured to be the same.

The specific principle and implementation of the control method of the sample analyzer 100 provided in this embodiment are similar to those of the sample analyzer 100 described above, and will not be described in detail here.

The foregoing description is only of the preferred embodiments of the present invention and is not intended to limit the scope of the invention, and all equivalent structural changes made by the description of the present invention and the accompanying drawings or direct/indirect application in other related technical fields are included in the scope of the invention.

Claims

1. A sample analyzer, characterized by: comprises an analyzer execution body and a controller;

the sample device is used for carrying a sample container loaded with a sample;

The diluent device is used for supplying diluent;

2. A sample analyzer, characterized by: comprises an analyzer execution body and a controller;

the sample device is used for carrying a sample container loaded with a sample;

the diluent device is used for supplying diluent;

3. The sample analyzer of claim 1 or 2, wherein: the controller is configured to: controlling the sample needle to absorb the sample from the sample container once and store the sample in the sample adding device, wherein the sample amount is larger than or equal to the sample required amount of at least two sample detection items; and controlling the sample needle to dispense the samples stored in the sample adding device to at least two reaction containers according to the sample required amount of each sample detection item.

4. A sample analyzer as claimed in claim 3, wherein: the controller is configured to: the sample needle is controlled to suck the sample from the sample container and store the sample in the sample adding device at one time, and the sample amount is larger than or equal to the sample required amount of all sample detection projects required to be executed by the sample in the sample container.

5. The sample analyzer of claim 4, wherein: the sample analyzer further comprises an interferent detection device, wherein the interferent detection device comprises an interferent detection container and an interferent detection component, and the interferent detection component is used for executing interferent detection on a third type of sample which is prepared by mixing a sample or a sample and a diluent in the interferent detection container;

the controller is further configured to control the sample needle to dispense the aspirated portion of the sample to the interferent detection vessel, and the controller is further configured to: and controlling the sample needle to suck the sample from the sample container once and store the sample in the sample adding device, wherein the sample amount is larger than or equal to the sum of the sample requirement of all sample detection items required to be executed by the sample in the sample container and the sample requirement of the interference object detection.

6. The sample analyzer of claim 2, wherein: the sample needle is a puncture needle having a puncture function, and the controller is configured to: the sample needle is controllable to pierce a sample container with a cap and draw sample from the sample container into the sample application device, and the sample needle is controllable to draw sample from a sample container without the cap into the sample application device; or,

the sample needle is a non-puncturing needle without puncturing function, the controller is configured to: the sample needle can be controlled to aspirate a sample from a sample container without the cap and store it in the sample application device.

7. The sample analyzer of claim 6, wherein: the sample analyzer further comprises a first cleaning device,

when the sample needle is a puncture needle, the controller is further configured to: controlling the sample needle to discharge a part of the sample to the first cleaning device after controlling the sample needle to suck the sample from the sample container with the cap and controlling the sample needle to withdraw from the sample container;

the first cleaning device is used for cleaning away the sample discharged by the sample needle.

8. The sample analyzer of claim 1 or 2 or 6 or 7, wherein: the controller is further configured to: controlling the sample needle to draw air to form a column of isolation air within the sample needle after controlling the sample needle to draw sample from the sample container into the sample application device and before controlling the sample needle to draw diluent from the diluent device into the sample application device;

the controller is further configured to: controlling the sample needle to dispense the diluent, the isolation gas column and at least a portion of the sample stored in the sample application device to the reaction vessel.

9. The sample analyzer of claim 1 or 2 or 6 or 7, wherein: the controller is further configured to: before controlling the sample needle to absorb diluent from the diluent device, judging whether a sample detection item to be added with the sample needs to be added with the diluent or not;

if so, firstly controlling the sample needle to suck the diluent required by one sample detection item from the diluent device, and then controlling the sample needle to dispense the sucked diluent and at least part of the sample into the reaction container;

if not, controlling the sample needle to dispense at least part of the aspirated sample into the reaction vessel.

10. The sample analyzer of claim 2 or 6 or 7, wherein: the controller is further configured to: and controlling the completion time of each diluted sample detection item and the completion time of each undiluted sample detection item to be the same, and configuring the interval time of any two adjacent sample detection items to be the same.

11. A method for controlling a sample analyzer, comprising:

12. A method for controlling a sample analyzer, comprising:

controlling a sample needle to suck a sample from a sample container and store the sample in a sample adding device;

13. The control method of a sample analyzer according to claim 11 or 12, characterized in that: the control sample needle is used for sucking the sample from the sample container, wherein the amount of the sample stored in the sample adding device is larger than or equal to the sample required amount of at least two sample detection items;

the controlling the sample needle to dispense the diluent and at least a portion of the sample stored in the sample addition device to the reaction vessel comprises: and controlling the sample needle to dispense the samples stored in the sample adding device to at least two reaction containers according to the sample required amount of each sample detection item.

14. The method of controlling a sample analyzer of claim 13, wherein: the control sample needle draws sample from the sample container into the sample application device in an amount greater than or equal to the sample demand for performing all sample testing items required for sample in the sample container.

15. The method of controlling a sample analyzer of claim 14, wherein: the control sample needle sucks the sample from the sample container and stores the sample in the sample adding device, wherein the sample amount is larger than or equal to the sum of the sample required amount of all sample detection items required to be executed by the sample in the sample container and the sample required amount of the interference object detection;

The control method further includes:

and controlling the sample needle to dispense the sample stored in the sample adding device to the interference object detection container.

16. The method of controlling a sample analyzer of claim 12, wherein: the control sample needle draws a sample from a sample container and stores the sample in a sample loading device, comprising:

controlling the sample needle to pierce the cap of the sample container and draw sample from the sample container to be stored in the sample adding device;

controlling withdrawal of the sample needle from the sample container;

and controlling the sample needle to discharge part of the sample to the first cleaning device.

17. The control method of a sample analyzer according to claim 11 or 12, characterized in that:

the control method further comprises, after controlling the sample needle to draw a sample from the sample container and store it in a sample application device, and before controlling the sample needle to draw a diluent from the diluent device and store it in a sample application device: controlling the sample needle to draw air to form a column of insulating air within the sample needle;

the controlling the sample needle to dispense a diluent and at least a portion of a sample stored in the sample addition device to the reaction vessel, comprising: controlling the sample needle to dispense the diluent, the isolation gas column and at least a portion of the sample stored in the sample application device to the reaction vessel.

18. The control method of a sample analyzer according to claim 11 or 12, characterized in that:

the control method further comprises, before controlling the sample needle to draw diluent from within the diluent device:

judging whether a sample detection item to be loaded needs to be loaded with diluent or not;

if so, firstly controlling the sample needle to suck the diluent required by a sample detection item from the diluent device, storing the diluent in the sample adding device, and then controlling the sample needle to dispense the diluent and at least part of the sample stored in the sample adding device to the reaction container;

19. The method of controlling a sample analyzer of claim 12, wherein: the control method further includes: and controlling the completion time of each diluted sample detection item and the completion time of each undiluted sample detection item to be the same, and configuring the interval time of any two adjacent sample detection items to be the same.