CN116077611A

CN116077611A - Traditional Chinese medicine compound with yang warming and heart benefiting effects

Info

Publication number: CN116077611A
Application number: CN202211545715.6A
Authority: CN
Inventors: 曹洪欣; 张华敏; 唐丹丽; 刘寨华; 王兆博; 李金霞; 李同达; 冯玲; 申力; 刘莹; 曹洪福
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-12-01
Filing date: 2022-12-01
Publication date: 2023-05-09

Abstract

A Chinese herbal compound with the effects of warming yang and tonifying heart is characterized in that: comprises the following components: 5-30 parts of radix codonopsis pilosulae, 5-30 parts of dwarf lilyturf tuber, 5-15 parts of coptis chinensis, 5-30 parts of snakegourd fruit, 5-30 parts of allium macrostemon, 5-9 parts of pinellia tuber, 5-30 parts of cassia twig, 5-30 parts of red paeony root, 5-30 parts of poria cocos, 5-20 parts of szechuan lovage rhizome, 5-15 parts of liquorice, 5-15 parts of ginger and 5-15 parts of Chinese date. The invention can obviously improve the symptoms of coronary heart disease and angina pectoris, dilate coronary stenosis, greatly improve the clinical curative effect and long-term benefit of coronary heart disease diagnosis and treatment, has obvious clinical effect, and is safe and reliable.

Description

Traditional Chinese medicine compound with yang warming and heart benefiting effects

Technical Field

The invention relates to the technical field of prescriptions for coronary heart disease, in particular to a traditional Chinese medicine compound with yang warming and heart benefiting effects.

Background

Several limitations of current coronary heart disease treatment methods: the comprehensive benefit is poor: coronary lesions are a lengthy pathological evolution process, and common antiplatelet drugs cannot participate in the plaque formation process, and the simple lipid-lowering treatment is also a cup-made salary. The current interventional therapy widely used for coronary heart disease treatment can not significantly reduce the occurrence and death rate of myocardial infarction. We still need to explore better coronary heart disease treatment methods that benefit from the combination. The safety is not enough: most of the side effects of western medicines are beneficial to the western medicines. Aspirin is the most commonly used secondary preventive drug for coronary heart disease, but also greatly increases the risk of bleeding events of elderly patients, so that many elderly people are in an embarrassing situation of no drug availability. In addition, statins are the primary lipid-lowering drugs, but their widespread myolytic pain and impairment of liver function makes many patients prohibitive.

Disclosure of Invention

Technical problem to be solved

Aiming at the defects of the prior art, the invention provides a traditional Chinese medicine compound with the effects of warming yang and tonifying heart, which essentially solves the problems.

Technical proposal

In order to achieve the above purpose, the invention is realized by the following technical scheme:

a Chinese medicinal compound with yang warming and heart benefiting effects comprises the following components: 5-30 parts of radix codonopsis pilosulae, 5-30 parts of dwarf lilyturf tuber, 5-15 parts of coptis chinensis, 5-30 parts of snakegourd fruit, 5-30 parts of allium macrostemon, 5-9 parts of pinellia tuber, 5-30 parts of cassia twig, 5-30 parts of red paeony root, 5-30 parts of poria cocos, 5-20 parts of szechuan lovage rhizome, 5-15 parts of liquorice, 5-15 parts of ginger and 5-15 parts of Chinese date.

Preferably, the astragalus root is added by 10-60 parts for regulating chest distress and shortness of breath.

Preferably, 3-10 parts of schisandra chinensis, 10-50 parts of raw dragon bone, 10-50 parts of raw oyster and 10-50 parts of mother-of-pearl are added for regulating insomnia and palpitation.

Preferably, 10 parts of cassia twig are added, and all parts of coptis chinensis are removed, so that the Chinese medicinal composition is used for regulating aversion to cold and cold limbs.

Preferably, the bitter orange is added in an amount of 5-20 parts for regulating chest and abdomen fullness and oppression.

Preferably, 5 parts of coptis chinensis is added, and the total parts of dwarf lilyturf tuber are removed, so that the yellow and thick tongue coating is regulated.

Preferably, 5-20 parts of curculigo rhizome, 5-20 parts of eucommia ulmoides and 5-20 parts of morinda officinalis are added for regulating waist soreness, aversion to cold and weakness of lower limbs.

A compound decoction method is characterized in that:

step one, soaking a compound medicine in clear water before decocting;

step two, pouring the compound medicine into a marmite for first decoction after soaking, wherein the water adding amount exceeds the medicine surface by 10 cm;

step three, decocting the first decoction for 40 minutes after boiling, pouring out the first decoction, and reserving the first decocted compound medicine;

step four, performing second decoction on the compound medicine after the first decoction, wherein the second decoction water quantity is smaller than the first decoction water quantity, boiling, then decocting for 30 minutes, and pouring out the second decoction;

and fifthly, mixing the first decoction amount with the second decoction amount.

Preferably, the compound medicine in the first step is soaked for 30 minutes if the compound medicine is a leaf-type or grass-type Chinese medicine, and soaked for one hour if the compound medicine is a mineral-type Chinese medicine; the mineral Chinese medicinal materials include Os Draconis, concha Ostreae and Concha Margaritifera.

Preferably, the materials are boiled with strong fire when not boiled, and are boiled with small fire, and the materials are continuously stirred in the boiling process.

Advantageous effects

The invention greatly improves the clinical curative effect and long-term benefit of coronary heart disease diagnosis and treatment, has obvious clinical effect and is safe and reliable. The compound can greatly improve the symptoms of coronary heart disease and angina pectoris, and simultaneously improve pathological coronary stenosis and atheromatous plaque.

Detailed Description

The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

The compound common components of the invention are as follows: radix codonopsis pilosulae (5-30 g), radix ophiopogonis (5-30 g), coptis chinensis (5-15 g), snakegourd fruit (5-30 g), allium macrostemon (5-30 g), pinellia ternate (5-9 g), cassia twig (5-30 g), red paeony root (5-30 g), poria cocos (5-30 g), ligusticum wallichii (5-20 g), liquorice (5-15 g), ginger (5-15 g) and jujube (5-15 g). The components can be flexibly adjusted in practical application, and the specific adjustment method is as follows: for chest distress and short breath, radix astragali 10-60g can be added; for patients with insomnia and palpitation, 3-10g of fructus Schisandrae chinensis, 10-50g of Os Draconis, 10-50g of Concha Ostreae and 10-50g of Concha Margaritifera can be added; for those with severe cold limbs and pale tongue, 10g of ramulus Cinnamomi can be added and rhizoma Coptidis is removed; for chest and abdomen fullness and distention, fructus Aurantii Immaturus 5-20g is added; for those with yellow and thick tongue fur, 5g of coptis chinensis and ophiopogon root can be added; for patients with soreness of waist, aversion to cold and weakness of lower limbs, 5-20g of rhizoma Curculiginis, 5-20g of cortex Eucommiae and 5-20g of radix Morindae officinalis can be added.

The decoction method comprises the following steps:

preparation: the environment of the marmite, the clean water and the cooking range should be spacious and ventilated.

The decocting flow is as follows: before decocting, the Chinese medicinal materials are soaked in clear water, and generally leaf and grass Chinese medicinal materials can be soaked for about 30 min, and mineral substances (Os Draconis, concha Ostreae, concha Margaritifera) can be soaked for about one hr. After the soaking, the medicine is poured into a marmite for first decoction, and the water adding amount is preferably about 10 cm above the surface of the medicine. The second decoction should be reduced and the tonic Chinese medicinal should be added with water.

The decoction time is as follows: boiling the first decoction, and decocting for 40 minutes; the second decoction is boiled and decocted for 30 minutes. Wherein Os Draconis, concha Ostreae, and Concha Margaritifera are decocted for 30 min.

Mastering the fire: when not boiling, the mixture is boiled with intense fire (big fire) and then boiled with slow fire (small fire), and the mixture needs to be stirred frequently during the boiling process.

Number and amount of decoction: each pair of traditional Chinese medicine needs to be decocted twice, the dosage of each decoction is about 150 milliliters, the two decocted dosages are mixed together to be 300 milliliters, and the mixture is divided into 2 or 3 parts for each time in the morning (in the middle) and evening.

The compound prescription has the main advantages that:

(1) Obvious clinical effects: the compound is prepared by several decades of clinical researches and practices, and has remarkable clinical effect of treating coronary heart disease. Clinical studies show that the rate of improvement of the symptoms of angina pectoris reaches 90.0%, the average stenosis degree of coronary stenosis is reduced (16.45+/-31.25)% (P < 0.01) after treatment, and the 43 parts of the stenosis at 76 parts of more than or equal to 50% disappear or reverse.

(2) Basic research is full: animal experiments show that the method can reduce the Atherosclerosis (AS) model rabbit aortic atherosclerosis plaque area by 54-58%, obviously reduce AS model rat atherosclerosis index and improve AS pathological changes of coronary arteries and aorta. The action mechanism of the 'yang warming and heart tonifying method' for resisting AS is various, and early researches show that the 'yang warming and heart tonifying method' can obviously reduce the CHO and LDL-C levels of AS rabbits, raise the HDL-C level and lighten lipid infiltration; inhibiting NF- κB activation of AS rat, reducing CRP and IL-6 content, and inhibiting inflammatory reaction; regulating and controlling various coagulation factors, inhibiting platelet aggregation and adhesion, and resisting thrombosis; meanwhile, the AS rat PI3K/AKT signal path is mediated, eNOS expression is promoted, and simultaneously, ET-1, ox-LDL and Ang II are synthesized and released, so that endothelial cell injury is relieved. All the above studies suggest a remarkable therapeutic effect of the recipe on atherosclerosis.

Safety and reliability: the Chinese herbal medicine compound composition is a Chinese herbal medicine commonly used in clinic, and has thousands of years of application history. Adverse reactions were not found in the relevant clinical and basic studies. In conclusion, the method has reliable safety.

The chemical components of each traditional Chinese medicine are searched by using a TCMSP database (https:// tcmspw.com/tcmsp.php), and a 0B value (bioavailability) is more than or equal to 30% and a DL value (component similarity) is more than or equal to 0.18 as screening standards. The co-screening method contains 97 main medicinal compounds, and the details are shown in table 1.

TABLE 1 information table of the effective ingredients of the formulations

Naringenin belongs to flavonoid compounds, is one of main medicinal components of allium macrostemon, is a natural superoxide and peroxy radical scavenger, and has remarkable antioxidation and anti-inflammatory effects. Naringin inhibits proliferation and migration of VSMC (vascular smooth muscle cells) in vitro and proliferation of neointima and lipid streaks in vivo through MAPK/NF- κB signaling pathway. Naringin also reduces the severity of endothelial dysfunction by modulating NO bioavailability and oxidative stress, and protects infarcted and ischemia damaged myocardium by improving mitochondrial function.

Stigmasterol and beta-sitosterol exist in medicines such as radix codonopsis pilosulae, radix paeoniae rubrathe and rhizoma pinelliae, can competitively inhibit the absorption of cholesterol (TC), induce the expression of cholesterol transporter-ABCA/ABCG series proteins, inhibit the uptake of modified lipoprotein by macrophages in the inflammatory process, and thus inhibit the processes of intra-plaque inflammation and lipid deposition. Can regulate multiple pathways to play a role in protecting I/R myocardium, and reduce ischemia/reperfusion injury and myocardial apoptosis area after infarction. And a plurality of researches prove that the stigmasterol and the beta-sitosterol have the functions of delaying arteriosclerosis and reversing arterial plaque

Quercetin (quercetin) is one of main components of ginseng, allium macrostemon, coptis chinensis and liquorice, has active hydroxyl groups in the structure, can reduce the formation of Reactive Oxygen Species (ROS) by inhibiting nicotinamide adenine dinucleotide phosphate oxidase and xanthine oxidase, inhibit the activities of Cyclooxygenase (COX) and Lipoxygenase (LOX), regulate the signal activity in inflammatory response cells, and has various characteristics such as antioxidation, endothelial protection, vasodilation and the like. Studies have shown that after 2 months of treatment with quercetin, the IL-1b, TNF-a and IL-10 values of patients with coronary heart disease are reduced to varying degrees, whereas intravenous injection of quercetin can reduce the size of Acute Myocardial Infarction (AMI) necrosis. The coptis contains a plurality of important medicinal components such as berberine (berberine), berberine (coptisine), palmatine hydrochloride (palmatine) and the like, can activate PI3K-Akt channels, increase the content of HIF1Q, promote the HIF-1 channel-mediated Sphk2 transcription and AMPK phosphorylation, and thus protect the non-ischemic region of the heart.

The method is applied to clinic for over 20 years, is widely used for diagnosing and treating the coronary heart disease for nearly 1 ten thousand times, has obvious clinical effect, is safe and reliable, does not find obvious adverse reaction, and is favored by patients with the coronary heart disease. The traditional treatment method can not essentially treat the cause of coronary heart disease for a long time, so the clinical effect is not satisfactory. The composition can improve coronary heart disease and angina pectoris, and also improve pathological coronary stenosis and atheromatous plaque. The mean stenosis degree of coronary artery stenosis is reduced (16.45+/-31.25)% (P < 0.01) after treatment, and the 43 is disappeared or reversed in 76-site stenosis more than or equal to 50%.

Case 1: the patient, male, 58 years old, needs to take nitroglycerin for 1 year's relief due to chest distress, shortness of breath, acid deposition on the back, at the first diagnosis of 4 months and 9 days in 2012. Chest distress, shortness of breath, acid sinking of the back, aversion to cold, fever at night, bitter taste at the even mouth, pale tongue with ecchymosis, yellow and little body fluid coating, wiry and slippery pulse. Coronary angiography shows: 100% of the 1 st diagonal branch is blocked, 90% of the right coronary artery middle section is stenosed, and 80% of the left anterior descending branch middle section is stenosed. Electrocardiographic representation: STII, III, avF, v2-v6 move down. Blood pressure 170/100mmHg. The past history of hypertension was 10 years. Western diagnosis: coronary heart disease. Diagnosis of traditional Chinese medicine: chest stuffiness is caused by heart yang failing to control blood stasis and phlegm stagnation, and liver yang hyperactivity is treated by warming yang and tonifying heart, activating blood and resolving phlegm, and suppressing liver yang. The prescription comprises the following components: 30g of selfheal, 20g of cassia seed, 20g of dangshen, 15g of dwarf lilyturf tuber, 10g of coptis chinensis, 15g of purified pinellia tuber, 15g of snakegourd fruit, 15g of longstamen onion bulb, 15g of red paeony root, 15g of szechuan lovage rhizome, 15g of Indian buead, 30g of raw dragon bone (decocted first), 30g of raw oyster (decocted first) and 10g of liquoric root. 20 doses, 1 dose daily, are decocted in water and taken 3 times.

Two diagnoses at 2012, 4 and 28 days: chest distress and shortness of breath are alleviated, body heat is alleviated at night, but there is discomfort in the precordial region and acid deposition in the back at the afternoon. Blood pressure 130/100mmHg. A pale-red and slightly purple tongue with a coating Huang Hua and a slippery pulse. Above, os Draconis and Concha Ostreae are removed, and fructus Aurantii Immaturus 15g, caulis Bambusae in Taenia 15g, ramulus Cinnamomi 10g, and ramulus Uncariae cum Uncis 30g are added. 30 doses are decocted and taken as before.

Three diagnoses in 2012, 5 and 27 days: precordial discomfort, stopping taking nitroglycerin, shortness of breath, heavy back, nausea in the morning, and discomfort at the corners of the mouth. Blood pressure 140/95mmHg. Pale-red and slightly purple tongue with thin and yellow coating, smooth pulse. Fructus Aurantii Immaturus and ramulus Cinnamomi are removed from the upper part, and rhizoma Polygonati 15g, rhizoma Curculiginis 10g and Os Draconis 30g (decocted first) are added. 30 doses are decocted and taken as before.

Four diagnoses at 2012, 7, 1 and four days: all symptoms disappear, and no obvious discomfort is caused. Blood pressure 130/85mmHg. The medicine is continuously taken for 270 doses by the conservation therapy. Coronary CT for 27 sun-checks at 2013, 4, month: the 1 st diagonal stenosis (25% -49%), the middle of the right coronary artery and the middle of the left anterior descending branch were moderately severe (50% -89%) and the electrocardiogram was approximately normal. The patient is treated by the method, has no obvious discomfort after 5 years of diagnosis, has normal electrocardiograph and biochemical indexes, and has no occurrence of cardiovascular accidents.

In terms of: the patient can show symptoms of liver yang hyperactivity such as hypertension, bitter taste, and fever besides typical heart yang deficiency, blood stasis and phlegm coagulation, and Prunellae Spica, semen Cassiae, ramulus Uncariae cum Uncis, os Draconis, and Concha Ostreae are added to calm liver and suppress yang based on warming yang and benefiting heart, promoting blood circulation and eliminating phlegm. 2. In three cases, blood pressure is lowered, body heat is not obvious, but symptoms of yang deficiency and phlegm heat are obvious, so ramulus Cinnamomi and rhizoma Curculiginis are added to excite heart yang, fructus Aurantii Immaturus and caulis Bambusae in Taenia clear heat and resolve phlegm. The daemon therapy is used for more than 1 year, and the clinical symptoms, coronary stenosis degree and electrocardiogram are obviously improved.

Case 2 implementation: patients, men, 64 years old, need to take nitroglycerin to relieve due to chest distress and precordial pain, and the first diagnosis is made on 2 months and 23 days after activity, more than 2 months after activity. The following symptoms: chest distress, precordial pain, palpitation, back pain, abdominal distention and obvious afternoon. Coronary CT shows: the first diagonal branch is occluded (100%), the left anterior descending branch is severely stenosed (75% -89%), and the right coronary artery is moderately stenosed (50% -75%). Dynamic electrocardiogram: ventricular premature contraction 5253 times/24 h with bivariate rhythm. The past history of hypertension is 3 years, and the history of diabetes is 10 years. Blood pressure 148/88mmHg. A pale-red, slightly purple-white, yellow-yellow and thick coating on the tongue and a slippery and rapid pulse. Western diagnosis: coronary heart disease, hypertension, diabetes. Diagnosis of traditional Chinese medicine: chest stuffiness, obstruction of phlegm-heat, malnutrition of heart-mind, and the actions of relieving chest stuffiness, resolving phlegm, nourishing heart, restoring pulse, and tranquilizing mind. The prescription comprises the following components: 10g of codonopsis pilosula, 15g of dwarf lilyturf tuber, 10g of shizandra berry, 10g of coptis chinensis, 15g of purified pinellia tuber, 15g of snakegourd fruit, 15g of allium macrostemon, 15g of magnolia officinalis, 15g of immature bitter orange, 15g of poria cocos, 30g of selfheal, 30g of raw dragon bone (decocted first), 30g of raw oyster (decocted first), 30g of mother-of-pearl (decocted first) and 10g of liquorice. 30 doses, 1 dose daily, are decocted in water and taken for 3 times.

Two diagnoses in 2013, 4 and 12 days: back pain, palpitation, and subjective strength increase, sometimes chest pain and abdominal distention, and nitroglycerin is taken 2 times during the period. Dynamic electrocardiogram: ventricular extra-systole 1577 times/24 h, paroxysmal ST-T changes. Blood pressure is 128/88mmHg. Pale purple tongue with pale yellow and thick coating and slippery pulse. Above, removing fructus Schisandrae chinensis and Concha Margaritifera, adding ramulus Cinnamomi 10g and radix Sophorae Flavescentis 10g.30 doses are decocted and taken as before.

Three diagnoses in 2013, 7, 15 days: the administration of the preparation 90 times above the preparation reduces the times of chest pain, the palpitation basically disappears, and the pain in the precordial region is occasionally caused, and the nitroglycerin is taken for 1 time. Blood pressure 160/90mmHg. A purple tongue with white and thick coating and a slippery pulse. The prescription comprises the following components: ramulus Cinnamomi and fructus Aurantii Immaturus are removed from the upper part, and 10g of Saviae Miltiorrhizae radix, 30g of ramulus Uncariae cum Uncis and 30 doses are added.

Four diagnoses in 2013, 11, 3 and four days: 60 doses above are taken, the pain in the precordial region is basically eliminated, the palpitation is relieved, and the nitroglycerin is not taken. The decoction 120 doses are intermittently taken by the goats in the goats of 10 and 25 days in 2014: first diagonal branch, left anterior descending branch severe stenosis (75% -89%), right coronary artery moderate stenosis (50% -74%). The treatment is carried out by the conservation method, the patients with palpitation are treated by following the diagnosis for 3 years, the nitroglycerin is stopped taking, the biochemical indexes are normal, and no cardiovascular accident occurs.

In terms of: the patient is characterized by chest distress precordial pain and ventricular premature contraction, syndrome differentiation is mainly characterized by phlegm-heat blockage, on the basis of a yang warming and heart benefiting method, dragon bone, oyster and mother-of-pearl are sequentially added, heart is calm and palpitation is calm, chinese magnoliavine fruit and kuh-seng are used for heart nourishing and pulse recovery, magnolia officinalis and immature bitter orange regulate qi and reduce phlegm to regulate heart rhythm, precordial pain of the patient is basically eliminated after treatment, nitroglycerin is stopped taking, and dynamic electrocardiogram is rechecked to display that the ventricular premature contraction is obviously reduced, pulse promotion is not generated, and simultaneously the coronary artery stenosis degree is obviously reduced.

Implementation case 3: patients, men, age 48, were first diagnosed in 2013, 6, 23 days due to "short breath after activity, 1 year back sinking". The following symptoms: shortness of breath after activity, sinking back, aversion to cold, cold limbs, premature ejaculation, suspicion of anxiety and low emotion. Coronary angiography shows: the left anterior descending branch is more than 90% in middle section, the first diagonal branch is 100% occluded, the middle section of the circumflex branch is 50% in middle section, and the right coronary artery is 50% in middle section. Blood pressure 120/70mmHg. The tongue is dark, red, ecchymosis, yellow and white in coating and the pulse is wiry and slippery. Western diagnosis: coronary heart disease. Diagnosis of traditional Chinese medicine: chest stuffiness is caused by heart yang deficiency and stagnation of phlegm stasis, so it is indicated for yang-warming, heart-tonifying, blood-activating and phlegm-resolving. The prescription comprises the following components: 20g of codonopsis pilosula, 15g of dwarf lilyturf tuber, 7g of coptis chinensis, 15g of purified pinellia tuber, 15g of snakegourd fruit, 15g of allium macrostemon, 15g of poria cocos, 15g of red paeony root, 15g of szechuan lovage rhizome, 10g of cassia twig, 15g of immature bitter orange, 10g of common curculigo rhizome, 10g of epimedium herb, 30g of raw dragon bone (decocted first) and 10g of liquorice. 20 doses, 1 dose daily, are decocted in water and taken for 3 times.

Two diagnoses in 2013, 7 and 16 days: shortness of breath, sinking back, reduced anxiety, dizziness due to morning vision, sneeze, aversion to cold, tinnitus, sleep disturbance, and dribbling after urination. Blood pressure 118/82mmHg. The tongue is fat, dark red, slightly purple with white coating, little body fluid, and wiry and slow pulse. Removing ramulus Cinnamomi, rhizoma Curculiginis, herba Epimedii, fructus Aurantii Immaturus, and Os Draconis, and adding fructus Schisandrae 10g, rhizoma Polygonati 2g, periostracum Cicadae 15g, herba Schizonepetae 15g, and caulis Polygoni Multiflori 30g.30 doses are decocted before taking.

Three diagnoses in 2013, 8, 18 days: sneeze, sleep, dribbling after urine, blurred vision, and tinnitus with symptoms of heart condition, lower abdomen, waist and arm on both sides scattered on eczema, and constipation, and 1 time a day. Blood pressure is 128/70mmHg. Pale-red and slightly dark tongue with white coating and wiry and slippery pulse. Removing fructus Schisandrae chinensis, rhizoma Polygonati, periostracum Cicadae, herba Schizonepetae, and caulis Polygoni Multiflori, and adding radix Puerariae 20g, radix Sophorae Flavescentis 10g, kochiae fructus 15g, fructus Vitics Simplicifoliae 15g, and Eucommiae cortex 15g.30 doses are decocted and taken as before.

Four diagnoses in 2013, 9 and 21 days: skin eczema is not treated, but is sometimes treated by nasal obstruction and sneeze, and is sometimes painful in precordial region and comfortable. Blood pressure 130/80mmHg. The decoction is taken after 250 doses of the decoction. Coronary CT for 10 months and 14 days 2014: severe stenosis in the middle of the anterior left descending branch (75-89%), stenosis in the middle of the first diagonal, circumflex branch, and right coronary artery by 50%. The disease is stable after 2 years of diagnosis, and no cardiovascular accident occurs.

In terms of: the patient has the symptoms of anxiety and low emotion on the basis of coronary heart disease. The heart is mainly clear, and the heart yang failing to control can cause emotional changes, and the syndrome differentiation is mainly based on yang deficiency and phlegm stasis, and the yang warming and heart tonifying method is combined with the two immortals Shang Wenyang to benefit the heart, activate blood and resolve phlegm. In the second diagnosis, the patients have shortness of breath, no sinking back, reduced anxiety, but allergic rhinitis, and dribbling urine, and the periostracum Cicadae and herba Schizonepetae are used for dispelling pathogenic wind and desensitizing, and rhizoma Polygonati and fructus Schisandrae chinensis are used for reinforcing kidney and reducing urine. The three diagnosis and treatment are combined with eczema, and the kuh-seng, the fructus kochiae, the wind-dispelling and itching-relieving functions are used for clearing the head and eyes, and the eucommia ulmoides tonifies are used for reinforcing the curative effect. The daoyin treatment is more than 1 year, the first diagonal coronary occlusion is recanalized, and the rest stenosis degree is obviously reduced.

Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A Chinese herbal compound with the effects of warming yang and tonifying heart is characterized in that: comprises the following components: 5-30 parts of radix codonopsis pilosulae, 5-30 parts of dwarf lilyturf tuber, 5-15 parts of coptis chinensis, 5-30 parts of snakegourd fruit, 5-30 parts of allium macrostemon, 5-9 parts of pinellia tuber, 5-30 parts of cassia twig, 5-30 parts of red paeony root, 5-30 parts of poria cocos, 5-20 parts of szechuan lovage rhizome, 5-15 parts of liquorice, 5-15 parts of ginger and 5-15 parts of Chinese date.

2. The traditional Chinese medicine compound with the effects of warming yang and tonifying heart according to claim 1, which is characterized in that: radix astragali 10-60 parts can be added for regulating chest distress and short breath.

3. The traditional Chinese medicine compound with the effects of warming yang and tonifying heart according to claim 1, which is characterized in that: also comprises 3-10 parts of schisandra chinensis, 10-50 parts of raw dragon bone, 10-50 parts of raw oyster and 10-50 parts of mother-of-pearl for regulating insomnia and palpitation.

4. The traditional Chinese medicine compound with the effects of warming yang and tonifying heart according to claim 1, which is characterized in that: also add 10 parts of cassia twig, and remove all parts of coptis chinensis, and can be used for regulating aversion to cold and cold limbs.

5. The traditional Chinese medicine compound with the effects of warming yang and tonifying heart according to claim 1, which is characterized in that: fructus Aurantii Immaturus 5-20 parts can be added for regulating chest and abdomen fullness and oppression.

6. The traditional Chinese medicine compound with the effects of warming yang and tonifying heart according to claim 1, which is characterized in that: also adding 5 parts of coptis chinensis and removing all parts of dwarf lilyturf tuber for regulating the yellow and thick tongue fur.

7. The traditional Chinese medicine compound with the effects of warming yang and tonifying heart according to claim 1, which is characterized in that: also comprises 5-20 parts of rhizoma Curculiginis, 5-20 parts of cortex Eucommiae and 5-20 parts of radix Morindae officinalis for regulating soreness of waist, aversion to cold, and weakness of lower limbs.

8. A compound decoction method according to any one of claims 1-7, characterized in that:

step one, soaking a compound medicine in clear water before decocting;

9. The method of claim 8, wherein: the compound medicine in the first step is soaked for 30 minutes if the compound medicine is leaf-type or grass-type Chinese medicine, and soaked for one hour if the compound medicine is mineral-type Chinese medicine; the mineral Chinese medicinal materials include Os Draconis, concha Ostreae and Concha Margaritifera.

10. The method of claim 8, wherein: the method of claim 8, wherein: decocting with strong fire when not boiling, decocting with slow fire after boiling, and stirring continuously during the decoction.