CN116068210A

CN116068210A - Blood sample analyzer

Info

Publication number: CN116068210A
Application number: CN202111276251.9A
Authority: CN
Inventors: 方朝斌; 石汇林
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2021-10-29
Filing date: 2021-10-29
Publication date: 2023-05-05

Abstract

The invention is applicable to the field of blood sample analysis equipment, and discloses a blood sample analyzer, which comprises a shell, a rack, a sampling assembly and a blood routine detection assembly; the rack is arranged in the shell and comprises a front plate, a rear plate, a bottom plate and a top plate; the sampling assembly and the blood routine detection assembly are both arranged on the frame; the blood routine detection assembly comprises an impedance counting detection assembly, the impedance counting detection assembly comprises an impedance counting detection part and an impedance detection circuit board electrically connected with the impedance counting detection part, the impedance counting detection part is arranged between the front plate and the rear plate, the impedance counting detection part is adjacent to or abutted to the front plate, and the impedance detection circuit board is arranged on one side of the impedance counting detection part, which is opposite to the rear plate. The invention is beneficial to reducing the volume and the cost of the blood sample analyzer and facilitating the disassembly and the maintenance of the impedance detection circuit board by optimally designing the structural layout of the blood sample analyzer.

Description

Blood sample analyzer

Technical Field

The invention relates to the field of blood sample analysis equipment, in particular to a blood sample analyzer.

Background

A blood sample analyzer is a device for analyzing a blood sample. The blood sample analyzer provided by the traditional technology has the defects of large volume, high cost and inconvenient overhaul and maintenance due to unreasonable structural layout. Specifically, the conventional technology provides a blood sample analyzer, and the common position setting scheme of the impedance counting detection assembly comprises the following two types: the first is arranged in front of the front plate of the frame, and the second is arranged in the middle of the frame or near the rear plate. However, both of these positioning schemes have drawbacks in specific applications, which are embodied as follows:

1) The impedance counting detection assembly is arranged in front of the front plate, so that a liquid path connecting pipeline between the impedance counting detection assembly and other components is long, and the volume and the cost of the blood sample analyzer are large;

2) The impedance counting detection assembly is arranged in the middle of the frame or near the rear plate, so that the impedance detection circuit board on the impedance counting detection assembly is inconvenient to disassemble and maintain in the future.

Disclosure of Invention

The invention aims to provide a blood sample analyzer, which aims to solve the technical problem that the impedance counting detection assembly is unreasonable in position setting in the traditional technology.

In order to achieve the above purpose, the invention provides the following scheme: a blood sample analyzer comprising a housing, a frame, a sampling assembly, and a blood routine detection assembly;

the machine frame is arranged in the shell and comprises a front plate, a rear plate, a bottom plate and a top plate, wherein the front plate and the rear plate are respectively positioned on two opposite sides of the machine frame, the bottom plate and the top plate are both positioned between the front plate and the rear plate, and the top plate is arranged above the bottom plate at intervals;

the sampling assembly is mounted on the frame for collecting a blood sample from within a sample container and dispensing at least a portion of the collected blood sample to the blood routine testing assembly;

The blood routine detection assembly comprises an impedance counting detection assembly, wherein the impedance counting detection assembly is used for detecting red blood cell parameters and/or platelet parameters of a blood sample, the impedance counting detection assembly comprises an impedance counting detection component and an impedance detection circuit board electrically connected with the impedance counting detection component, the impedance counting detection component is arranged between the front board and the rear board, the impedance counting detection component is adjacent to or abutted to the front board, and the impedance detection circuit board is arranged on one side of the impedance counting detection component, which is opposite to the rear board.

According to the blood sample analyzer provided by the invention, the impedance counting detection component is arranged between the front plate and the rear plate, namely, the impedance counting detection component is arranged at the rear of the front plate, so that the liquid path connecting pipeline of the impedance counting detection component and other components is shorter, and the volume and cost of the blood sample analyzer are reduced. In addition, the impedance counting detection component is arranged adjacent to or abutted against the front plate, and the impedance detection circuit board is arranged on one side of the impedance counting detection component, which is opposite to the rear plate, so that no other component exists between the impedance detection circuit board and the front plate, the impedance detection circuit board is convenient to detach and maintain in the future, and the overhaul and maintenance efficiency of the impedance detection circuit board is improved.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to the structures shown in these drawings without inventive effort for a person skilled in the art.

FIG. 1 is an exploded schematic view of a blood sample analyzer provided in an embodiment of the present invention;

FIG. 2 is a perspective view of a blood sample analyzer according to an embodiment of the present invention;

FIG. 3 is a perspective view of a blood sample analyzer according to an embodiment of the present invention;

FIG. 4 is a perspective view of a blood sample analyzer according to an embodiment of the present invention with a housing removed;

FIG. 5 is a schematic front plan view of a blood sample analyzer according to an embodiment of the present invention with a housing removed;

FIG. 6 is a schematic plan view of a blood sample analyzer according to an embodiment of the present invention with a housing removed;

FIG. 7 is a schematic plan view of a blood sample analyzer according to an embodiment of the present invention with a housing removed;

FIG. 8 is an enlarged partial schematic view at A in FIG. 7;

FIG. 9 is a schematic rear plan view of a blood sample analyzer according to an embodiment of the present invention with a housing removed;

FIG. 10 is a schematic top plan view of a blood sample analyzer provided in an embodiment of the present invention with a housing removed;

FIG. 11 is an exploded view of a first embodiment of the present invention with a blood sample analyzer housing removed;

FIG. 12 is a second exploded view of a blood sample analyzer according to an embodiment of the present invention with a housing removed;

FIG. 13 is a schematic diagram showing the distribution of a sampling assembly, a hemoglobin detection assembly, and an optical detection reaction cell according to an embodiment of the present invention;

FIG. 14 is a schematic perspective view of a sample assembly and swab provided in accordance with embodiments of the present invention;

FIG. 15 is a perspective view of a frame according to an embodiment of the present invention;

FIG. 16 is a perspective view of another view of a frame provided by an embodiment of the present invention;

fig. 17 is a schematic perspective view of an assembly of a dye liquor reagent carrying assembly, a dye liquor reagent fixing assembly and a dye liquor reagent container according to an embodiment of the present invention;

fig. 18 is a schematic view showing a state that a dye liquor reagent carrying assembly provided by the embodiment of the invention carries a dye liquor reagent container sliding on a dye liquor reagent fixing assembly;

FIG. 19 is an exploded view of a power assembly provided in an embodiment of the present invention;

FIG. 20 is a schematic diagram illustrating assembly of a manifold and a sampling control valve set according to an embodiment of the present invention;

fig. 21 is a schematic diagram of a liquid path system of a blood sample analyzer according to an embodiment of the present invention.

Reference numerals illustrate: 1. a blood sample analyzer; 10. a housing; 11. a front shell; 111. a display screen; 112. a front case body; 1121. a third opening; 113. a door panel; 12. a rear case; 13. a top shell; 14. a bottom case; 15. a first side case; 16. a second side case; 20. a frame; 21. a front plate; 211. a first opening; 22. a rear plate; 221. a second opening; 23. a bottom plate; 24. a top plate; 25. a first side portion; 26. a second side portion; 27. a middle partition plate; 28. a first side plate; 29. a liquid path partition; 210. rotating the connecting plate; 30. a sampling assembly; 31. a sampling needle; 32. a motion driving device; 321. a lifting driving mechanism; 322. a horizontal driving mechanism; 33. a sample suction pipeline; 40. a blood routine detection component; 41. an impedance count detection component; 411. an impedance count detecting section; 4111. an impedance detection cell; 412. an impedance detection circuit board; 42. a hemoglobin detection assembly; 421. a first reaction tank; 422. a hemoglobin detection section; 43. an optical detection assembly; 431. a reaction cell for optical detection; 4311. a second reaction tank; 4312. a third reaction tank; 432. an optical detection member; 4321. a flow chamber; 44. preparing a control valve by a first sample; 45. a first sample preparation tube; 46. impedance sheath fluid bath; 47. impedance sheath fluid control valve bank; 48. sample preparation control valve group; 481. a second sample preparation control valve; 482. a third sample preparation control valve; 483. a fourth sample preparation control valve; 49. a second sample preparation tube; 410. a third sample preparation tube; 50. a dye liquor quantifying component; 60. a dye liquor reagent bearing assembly; 61. a carrying part; 62. a first sliding portion; 63. a baffle; 70. a dye liquor reagent fixing component; 71. a connection part; 72. a second sliding part; 73. a limit buffer member; 80. a swab; 90. cleaning a filter by a swab; 101. a blood sedimentation detection assembly; 102. a first syringe; 103. a second syringe; 104. a bus plate; 105. a sampling control valve group; 1051. a first control valve; 1052. a second control valve; 1053. a third control valve; 1054. a fourth control valve; 106. a diluent switching valve; 107. an optical sheath fluid delivery line; 108. an optical sheath fluid control valve; 109. a hydraulic pressure detection assembly; 201. a liquid path inlet and outlet interface assembly; 2011. a DR diluent inlet; 2012. an LD hemolytic agent inlet; 2013. an LH hemolytic agent inlet; 2014. DS diluent inlet; 2015. a waste liquid outlet; 202. a liquid detection assembly; 203. a dosing pump assembly; 204. a diluent reservoir; 205. a waste liquid pool; 206. a waste liquid pump assembly; 207. a waste valve assembly; 2071. RET Chi Feiye valve; 2072. DIFF Chi Feiye valve; 2073. a swab waste liquid valve; 2074. HGB Chi Feiye valve; 208. a DR diluent dosing valve; 2081. DR diluent quantitative air valve; 2082. LD hemolysis agent quantitative liquid valve; 2083. LH hemolytic agent quantitative liquid valve; 2084. LD hemolysis agent quantitative air valve; 2085. a LH hemolytic agent quantitative air valve; 209. a gas chamber; 301. a control valve assembly; 302. an isolation chamber; 303. an air pressure detection circuit board; 304. a radio frequency identification card reader; 305. a shielding assembly; 306. an RFID antenna; 307. a power supply assembly; 3071. a mounting shell; 3072. a power supply; 3073. a first heat radiation fan; 3074. an air inlet; 3075. an air outlet; 3076. a wire outlet; 3077. a power switch; 3078. a power socket; 308. a circuit board assembly; 3081. a main control board; 3082. a motherboard; 309. an air pump; 401. a second heat radiation fan; 2. dye liquor reagent container.

Detailed Description

The following description of the embodiments of the present invention will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

It should be noted that all directional indications (such as up, down, left, right, front, and rear … …) in the embodiments of the present invention are merely used to explain the relative positional relationship between the components, the movement condition, etc. in a specific posture, and if the specific posture is changed, the directional indication is changed accordingly.

As shown in fig. 1, 2 and 4, a blood sample analyzer 1 according to an embodiment of the present invention includes a housing 10, a frame 20, a sampling assembly 30 and a blood routine detecting assembly 40, wherein the frame 20 is disposed in the housing 10, and the sampling assembly 30 and the blood routine detecting assembly 40 are mounted on the frame 20. The housing 10 serves as an external component of the blood sample analyzer 1, which serves to ensure the aesthetic appearance of the blood sample analyzer 1 on the one hand, and to ensure the dustproof and waterproof effects of the internal components of the blood sample analyzer 1 on the other hand. The housing 20 is mainly used as a main support structure for the internal components of the blood sample analyzer 1. The sampling assembly 30 is mainly used for realizing the sampling and sample dispensing functions of the blood sample analyzer 1. The blood routine testing assembly 40 is primarily used to perform a sample testing function of the blood sample analyzer 1, which may perform the testing of at least one sample parameter on a blood sample.

Referring to fig. 2, 15 and 16, as an embodiment, the frame 20 includes a front plate 21, a rear plate 22, a bottom plate 23 and a top plate 24, the front plate 21 and the rear plate 22 being located at opposite sides of the frame 20, respectively, the bottom plate 23 and the top plate 24 being located between the front plate 21 and the rear plate 22, and the top plate 24 being spaced above the bottom plate 23. Specifically, the front plate 21 and the rear plate 22 are disposed in opposition at intervals in the horizontal direction, and the top plate 24 and the bottom plate 23 are disposed in opposition at intervals in the vertical direction. The front plate 21 is located at the front side of the frame 20 and is disposed close to the front of the blood sample analyzer 1, and the front of the blood sample analyzer 1 specifically refers to a portion of the blood sample analyzer 1 facing the user to facilitate the user to manipulate the blood sample analyzer 1. The rear plate 22 is located at the rear side of the frame 20, near the back of the blood sample analyzer 1.

Referring to fig. 2, 15 and 16, as one embodiment, the frame 20 further includes a first side 25 and a second side 26, the first side 25 and the second side 26 extending from opposite sides of the front plate 21 to the rear plate 22, respectively. In the present embodiment, the outer contour of the chassis 20 is substantially rectangular parallelepiped, and the front plate 21, the rear plate 22, the top plate 24, the bottom plate 23, the first side 25, and the second side 26 are located on six sides of the rectangular parallelepiped. Of course, the shape of the outer contour of the frame 20 is not limited thereto, and may be, for example, a pentagonal or hexagonal shape or other shape.

Referring to fig. 2, 15 and 16, as an embodiment, the first side 25 is a left side of the frame 20, the second side 26 is a right side of the frame 20, and the blood routine detection assembly 40 is located on the right side of the frame 20, however, in a specific application, the blood routine detection assembly 40 may be located on the left side of the frame 20 as an alternative embodiment.

Referring to fig. 2, 15 and 16, as an embodiment, the rack 20 further includes a middle partition 27, the middle partition 27 is respectively abutted against the front plate 21, the rear plate 22, the bottom plate 23 and the top plate 24, the middle partition 27 is spaced apart from the first side 25 and spaced apart from the second side 26, the sampling unit 30 is mounted on the middle partition 27, and the blood routine detecting unit 40 is disposed between the middle partition 27 and the second side 26. The middle partition 27 divides the housing 20 into two chambers, a left chamber and a right chamber.

Referring to fig. 2, 15 and 16, as an embodiment, the rack 20 further includes a first side plate 28, the first side plate 28 is in contact with the front plate 21, the rear plate 22, the bottom plate 23 and the top plate 24, respectively, and the first side plate 28 is disposed between the first side portion 25 and the middle partition 27, and the first side plate 28 is spaced from the middle partition 27 and from the first side portion 25.

Referring to fig. 2, 15 and 16, as an embodiment, the frame 20 further includes a liquid path partition 29, the liquid path partition 29 being provided between the top plate 24 and the bottom plate 23 in the vertical direction, and the liquid path partition 29 being provided between the middle partition 27 and the second side portion 26. The liquid path bulkhead 29 is connected to at least one of the front plate 21, the rear plate 22, and the middle bulkhead 27.

Referring to fig. 1 to 3, as one embodiment, the housing 10 includes a front case 11, a front plate 21 is positioned between the front case 11 and a rear plate 22, and the front case 11 is provided with a display screen 111. The display screen 111 may be a touch screen having both a display function and a touch function, or may be a screen having only a display function.

Referring to fig. 1 to 3, as an embodiment, the case 10 further includes a rear case 12, a top case 13, a bottom case 14, a first side case 15, and a second side case 16, the rear case 12 being spaced rearward of the front case 11, the top case 13 and the bottom case 14 extending from top and bottom ends of the front case 11 to the rear case 12, respectively, and the first side case 15 and the second side case 16 being located at left and right sides of the front case 11, respectively. In this embodiment, the front case 11, the rear case 12, the top case 13, the bottom case 14, the first side case 15 and the second side case 16 are six parts detachably connected to each other, so that the disassembly and maintenance of the internal parts of the blood sample analyzer 1 from different orientations are facilitated; of course, in specific applications, as an alternative embodiment, five of any adjacent two, any adjacent three, or any adjacent four of the front case 11, the rear case 12, the top case 13, the bottom case 14, the first side case 15, and the second side case 16 may be designed as an integral design or as a non-detachable connection structure.

Referring to fig. 4 and 11, as one embodiment, the blood routine detection assembly 40 includes an impedance count detection assembly 41, the impedance count detection assembly 41 being configured to detect red blood cell parameters and/or platelet parameters of a blood sample. Specifically, the impedance count detecting component 41 mainly detects parameters of particles by impedance method. The impedance count detecting assembly 41 includes an impedance count detecting section 411 and an impedance detecting circuit board 412 electrically connected to the impedance count detecting section 411. The impedance count detecting unit 411 is disposed between the front plate 21 and the rear plate 22, that is, the impedance count detecting unit 411 is disposed behind the front plate 21, so that the liquid path connecting pipeline between the impedance count detecting unit 41 and other components is shorter, thereby being beneficial to reducing the volume and cost of the blood sample analyzer 1.

Referring to fig. 4, 6, 11 and 15, as an embodiment, the impedance count detecting section 411 is adjacent to or abuts against the front plate 21, and the impedance detecting circuit board 412 is provided on a side of the impedance count detecting section 411 facing away from the rear plate 22. The front plate 21 has a rear surface of the front plate 21 disposed toward the rear plate 22, and the impedance count detecting section 411 is adjacent to or abutted against the front plate 21, specifically including the following cases: in the first embodiment, the impedance count detecting section 411 is disposed adjacent to the front plate 21, and there is a space between the impedance count detecting section 411 and the back surface of the front plate 21, and there is no other section except for the impedance detecting circuit board 412 which may exist and the connection section 71 for connecting the impedance detecting circuit board 412 and the impedance count detecting section 411; in the second embodiment, the impedance count detecting section 411 is provided in contact with the front plate 21, and there is no space between the impedance count detecting section 411 and the back surface of the front plate 21. Whether the impedance counting detecting component 411 is adjacent to or abuts against the front plate 21, since the impedance detecting circuit board 412 is disposed on the side of the impedance counting detecting component 411 opposite to the rear plate 22, no other component blocking exists between the impedance detecting circuit board 412 and the front plate 21, so that the impedance detecting circuit board 412 is convenient to disassemble and maintain in the future, and the overhaul and maintenance efficiency of the impedance detecting circuit board 412 is improved.

Referring to fig. 4, 6, 11 and 15, as an embodiment, the front plate 21 is provided with a first opening 211 therethrough, and the first opening 211 is disposed opposite to the impedance detecting circuit board 412 for providing a space for escape for mounting and dismounting the impedance detecting circuit board 412 on the impedance count detecting section 411. In a specific application, a user or other operator may detach and install the impedance detection circuit board 412 through the first opening 211 in front of the blood sample analyzer 1, thereby facilitating the maintenance and repair of the impedance detection circuit board 412.

Referring to fig. 4, 6, 11 and 15, as an embodiment, the impedance detecting circuit board 412 is at least partially disposed through the first opening 211, that is: the size of the first opening 211 is larger than that of the impedance detection circuit board 412, and the impedance detection circuit board 412 is embedded in the first opening 211, so that a user or other operators can detach and install the impedance detection circuit board 412 through the first opening 211, and the structural compactness of the blood sample analyzer 1 is improved. Of course, in a specific application, the relative position of the impedance detection circuit board 412 and the first opening 211 is not limited thereto, for example, as an alternative embodiment, the impedance detection circuit board 412 may be disposed behind the first opening 211 in a horizontal direction, that is: the impedance detection circuit board 412 is located between the first opening 211 and the impedance count detection component 411, and the first opening 211 is capable of passing through the impedance detection circuit board 412; alternatively, as another alternative embodiment, the impedance detecting circuit board 412 may be provided in front of the first opening 211 in the horizontal direction, that is: the first opening 211 is located between the impedance detection circuit board 412 and the impedance count detection section 411.

As an embodiment, the distance from the impedance count detecting section 411 to the bottom plate 23 is smaller than the distance from the top plate 24, that is, the impedance count detecting section 411 is disposed near the bottom of the chassis 20, and the impedance detecting circuit board 412 is disposed near the bottom of the chassis 20 corresponding to the first opening 211.

Referring to fig. 4, 6, 11 and 15, as an embodiment, the impedance count detecting section 411 is mounted on the base plate 23, that is, the impedance count detecting section 411 is supported and positioned by the base plate 23. Of course, in a specific application, the supporting and positioning manner of the impedance count detecting unit 411 is not limited thereto, and for example, as an alternative embodiment, the impedance count detecting unit 411 may be mounted on the front plate 21, or may be mounted on a stand 20 with a separate support plate.

Referring to fig. 4, 6, 11 and 15, as an embodiment, the impedance count detecting means 411 is located between the middle partition 27 and the second side 26, and the distance from the impedance count detecting means 411 to the second side 26 is smaller than the distance to the middle partition 27, that is, the impedance count detecting means 411 is located near the right lower side behind the front plate 21, which is advantageous for further improving the structural compactness of the product.

Referring to fig. 11 and 21, as an embodiment, the impedance counting detecting unit 411 includes an impedance detecting cell 4111 and two electrodes, the impedance detecting circuit board 412 includes a constant current source and an analyzing circuit, the impedance detecting cell 4111 is provided with a first chamber, a second chamber and a detecting hole, the first chamber is a main chamber of the detecting cell, a blood sample and a diluent first enter the first chamber, the detecting hole communicates the first chamber and the second chamber, and the detecting hole is a micropore with a smaller aperture. The two electrodes are respectively arranged in the first chamber and the second chamber, and the constant current source is connected with the two electrodes. When particles pass through the detection hole under the action of power, corresponding pulses are generated, the larger the particle volume is, the larger the resistance is increased when the particles pass through the detection hole, so that the generated pulses are larger, namely the amplitude of the pulses is in direct proportion to the volume of the particles, the frequency of the pulses is in direct proportion to the number of the particles, and an analysis circuit can draw a particle distribution curve of the sizes of the reaction particles by collecting the data of the pulse changes, so that the detection data of the particles are obtained.

Referring to fig. 4 and 21, as one embodiment, the blood routine testing assembly 40 further includes a hemoglobin testing assembly 42, the hemoglobin testing assembly 42 being configured to test a hemoglobin parameter of a blood sample. The hemoglobin detection assembly 42 includes a first reaction tank 421 and a hemoglobin detection member 422, the first reaction tank 421 being for preparing a blood sample into a blood sample for hemoglobin detection. The hemoglobin detection member 422 is provided on the outer periphery of the first reaction tank 421 for detecting hemoglobin parameters of the blood sample in the first reaction tank 421.

As one embodiment, the impedance count detection component 41 performs particle parameter detection using sheath flow impedance. The first reaction cell 421 is also used to prepare a blood sample for impedance detection. In the present embodiment, the first reaction cell 421 is used as a preparation site of a blood sample for impedance counting detection, in addition to a preparation site and a detection site of a hemoglobin detection sample, that is, a preparation site of a blood sample for impedance counting detection is integrally provided with a preparation site of a hemoglobin detection sample. In a specific application, a blood sample and a diluent are added into the first reaction tank 421 to react to obtain a first sample, and then a part of the first sample is pumped out of the first reaction tank 421 and conveyed to the impedance detection tank 4111 to be used as a blood sample for sheath flow impedance counting detection; then, a reagent is added to the first reaction cell 421 so that the first sample and the reagent are prepared into a hemoglobin-measuring sample. The first chamber is provided with a sample inlet and a diluent inlet which are arranged independently, a blood sample for impedance counting detection is pushed into the first chamber from the sample inlet of the first chamber, and diluent is pushed into the first chamber from the diluent inlet of the first chamber, so that particles are queued to pass through the detection hole under the wrapping of the diluent, and corresponding pulses are generated, thereby realizing sheath impedance counting detection. In this embodiment, the power of the particles passing through the detection hole is provided by the pushing power of the sample and the pushing power of the diluent.

As an embodiment, the first reaction tank 421 is mounted on the frame 20 and located between the front plate 21 and the rear plate 22, i.e. the first reaction tank 421 is also located at the rear of the front plate 21, so that the first reaction tank 421 and the impedance detection tank 4111 are connected by a pipeline.

Referring to fig. 4, 6 and 11, as an embodiment, the first reaction cell 421 is disposed close to the impedance counting detecting means 411, and the distance from the first reaction cell 421 to the front plate 21 is smaller than the distance from the rear plate 22, which is advantageous in that the piping between the first reaction cell 421 and the impedance detecting cell 4111 can be designed to be shorter, thereby facilitating both reduction of the volume of the blood sample analyzer 1 and reduction of the sample preparation amount of the blood sample for sheath impedance counting detection and the amount of the cleaning liquid required to clean the piping, ensuring the performance of impedance detection and the detection performance of hemoglobin.

Referring to fig. 4, 6, 11 and 21, as an embodiment, the blood sample analyzer 1 further includes a first sample preparation control valve 44, the first sample preparation control valve 44 is connected between the first reaction cell 421 and the impedance count detecting part 411 by a pipe, and the first sample preparation control valve 44 is disposed near the bottom of the first reaction cell 421. The blood sample analyzer 1 further includes a first sample preparation tube 45, the first sample preparation tube 45 being connected between the first sample preparation control valve 44 and the impedance detection cell 4111, the first sample preparation control valve 44 being connected between the first sample preparation tube 45 and the first reaction cell 421. One embodiment of the transfer of the blood sample from the first reaction cell 421 to the impedance detection cell 4111 is: the first sample preparation control valve 44 is controlled to be opened to conduct the first sample preparation tube 45 and the first reaction cell 421, and then the blood sample in the first reaction cell 421 is sucked to the first sample preparation tube 45 by the sample suction power means; the first sample preparation control valve 44 is controlled to close to disconnect the first sample preparation tube 45 from the first reaction cell 421, and finally the blood sample in the first sample preparation tube 45 is pushed into the impedance detection cell 4111 by the sample pushing power means. In this embodiment, by optimally designing the position of the first sample preparation control valve 44, the distances between the first sample preparation control valve 44 and the first reaction tank 421 and the impedance detection tank 4111 are relatively short, so that the connecting lines between the first sample preparation control valve 44 and the first reaction tank 421 and between the first sample preparation control valve 44 and the impedance detection tank 4111 are relatively short, which is beneficial to reducing the sample preparation amount of the blood sample for sheath impedance counting detection and the amount of cleaning liquid required by the cleaning line, and is beneficial to improving the structural compactness of the blood sample analyzer 1.

Referring to fig. 4, 6 and 11, as an embodiment, the blood sample analyzer 1 further includes a rotation connection plate 210, an impedance sheath fluid reservoir 46 and an impedance sheath fluid control valve group 47, wherein the rotation connection plate 210 is disposed between the impedance counting detection part 411 and the back plate 22, and the rotation connection plate 210 is rotatably connected to the back plate 22, the impedance sheath fluid reservoir 46 is mounted on the rotation connection plate 210, and the impedance sheath fluid control valve group 47 is mounted on the rotation connection plate 210 and/or the bottom plate 23. The impedance sheath fluid control valve block 47 includes a plurality of valves for controlling the connection and disconnection of the line between the impedance sheath fluid reservoir 46 and the impedance detection reservoir 4111. In a preferred implementation of this embodiment, a portion of the valves in the impedance sheath fluid control valve block 47 are mounted on the rotating web 210 and another portion of the valves are mounted on the base plate 23. The impedance sheath tank 46 is used to provide a dilution liquid for forming sheath liquid for the impedance detection tank 4111. The impedance sheath tank 46 is connected to the diluent reservoir 204 through a pipeline for storing a certain amount of diluent, and the impedance sheath tank 46 is connected to the impedance detection tank 4111 through a pipeline. In this embodiment, by disposing the impedance sheath tank 46 and the associated control valve on the rotating connection plate 210, the impedance sheath tank 46 and the associated control valve can be made as close to the impedance detection tank 4111 as possible, so as to facilitate making the connecting pipeline between the impedance sheath tank 46 and the impedance detection tank 4111 smaller, reducing the influence of the cleaning solution and pipeline deformation, and fully utilizing the space between the impedance detection tank 4111 and the rear plate 22. In addition, since the rotary connecting plate 210 is rotatably connected to the rear plate 22, in particular applications, a user or other operator can see other parts inside the rotary connecting plate 210 by manually driving the rotary connecting plate 210 to rotate, thereby facilitating the overhaul and maintenance of the blood sample analyzer 1.

Referring to fig. 4, 6, 11 and 21, as an embodiment, the blood routine testing device 40 further includes an optical testing device 43, where the optical testing device 43 includes an optical testing reaction cell 431 and an optical testing component 432, the optical testing reaction cell 431 is used to prepare a blood sample for optical testing, and the optical testing component 432 is used to test a leukocyte parameter and/or a reticulocyte parameter of the blood sample. The optical detection unit 432 includes a flow chamber 4321 and an optical detection element, and the flow chamber 4321 is used for queuing and passing through the cells to be measured of the blood sample for optical detection under the wrapping of the diluent. The optical detection element comprises a light source, a forward scattered light signal collecting device, a side scattered light signal collecting device and a fluorescence signal collecting device. The light source is used for emitting light towards the cell to be tested flowing through the flow chamber 4321; the forward scattered light signal collecting device is used for collecting forward scattered signals generated by the light source irradiating the cells to be tested, and the forward scattered signals (also called low-angle scattered signals) collected by the forward scattered light signal collecting device can be used for representing the size of the volume of the cells to be tested. The side scattering light signal collecting device is used for collecting side scattering signals generated by the irradiation of the light source on the cells to be detected; the side scattering light signal collecting device is arranged at the side of the optical axis of the light emitted by the light source, and the collected side scattering signals (also called high-angle scattering signals) can represent the complexity of particles inside the cell to be detected. The fluorescence signal collecting device is used for collecting fluorescence signals generated by the irradiation of the light source on the cells to be tested. The fluorescence signal collecting device is arranged on the side of the optical axis of the light emitted by the light source, and the collected fluorescence signal intensity can represent the dyeing degree of the cells to be detected.

Referring to fig. 4, 6, 11, and 13, as an embodiment, the optical detection reaction cell 431 is provided between the first reaction cell 421 and the rear plate 22, that is, the optical detection reaction cell 431 is provided behind the first reaction cell 421 for hemoglobin detection in the horizontal direction.

Referring to fig. 4, 6, 11, 13, and 21, as an embodiment, the optical detection reaction cell 431 includes a second reaction cell 4311 and a third reaction cell 4312, the second reaction cell 4311 is used for preparing a blood sample into a blood sample for detecting a leukocyte parameter, the third reaction cell 4312 is used for preparing a blood sample into a blood sample for detecting a reticulocyte parameter, and the second reaction cell 4311 is provided between the first reaction cell 421 and the third reaction cell 4312. The first reaction tank 421 is also called HGB tank, the second reaction tank 4311 is also called DIFF tank, and the third reaction tank 4312 is also called RET tank, and the RET tank is not commonly used, so that the RET tank is used as a selection module and is arranged at the rear of the DIFF tank. The RET pool as a matching module specifically refers to: according to the requirements of users, a reaction tank for detecting the parameters of the reticulocytes and other related accessories are not required to be arranged. In this embodiment, the reaction cell 431 for optical detection includes two reaction cells, and the blood sample for leukocyte parameter detection and the blood sample for reticulocyte parameter detection are prepared by different reaction cells, so that on one hand, the problem of cross contamination caused by reagent residue when the reaction cells are shared can be avoided; on the other hand, the blood sample for detecting the leucocyte parameters and the blood sample for detecting the reticulocyte parameters can be prepared simultaneously, which is beneficial to improving the detection efficiency. Of course, in a specific application, the optical detection reaction cell 431 may include only one reaction cell, and the reaction cell may be time-multiplexed to prepare a blood sample for detecting a leukocyte parameter and a blood sample for detecting a reticulocyte parameter.

As an embodiment, as shown in fig. 4, 6 and 11, the optical detection member 432 is provided between the optical detection reaction cell 431 and the top plate 24, that is, the optical detection member 432 is located above the optical detection reaction cell 431. The distance from the optical detection part 432 to the rear plate 22 is smaller than the distance to the front plate 21. In the present embodiment, the optical detection unit 432 is disposed at the rear upper side of the rack 20, so that the optical detection unit 432 can be made closer to the optical detection reaction cell 431 in a limited space, thereby advantageously satisfying the requirements of low sample preparation amount and small cleaning liquid amount.

Referring to fig. 2, 6 and 11, as an embodiment, the blood sample analyzer 1 further includes a sample preparation control valve group 48, where the sample preparation control valve group 48 is connected between the optical detection reaction cell 431 and the optical detection component 432 through a pipeline, and the sample preparation control valve group 48 is used to control the on-off of a channel between the optical detection reaction cell 431 and the optical detection component 432, so as to implement preparation and sample pushing of the optical detection channel sample.

Referring to fig. 2, 6 and 11, as an embodiment, the sample preparation control valve group 48 is provided between the optical detection member 432 and the bottom plate 23, and the sample preparation control valve group 48 is provided between the optical detection reaction cell 431 and the rear plate 22, that is: the sample preparation control valve group 48 is located below the optical detection member 432 and behind the optical detection reaction cell 431. In this embodiment, by optimally designing the position of the sample preparation control valve group 48, the distances from the sample preparation control valve group 48 to the optical detection reaction tank 431 and the optical detection component 432 are relatively short, so that the connecting pipelines between the sample preparation control valve group 48 and the optical detection reaction tank 431 and between the sample preparation control valve group 48 and the optical detection component 432 are relatively short, which is beneficial to reducing the sample preparation amount of the blood sample for optical detection and the cleaning liquid amount required by the cleaning pipeline, and improving the structural compactness of the blood sample analyzer 1.

Referring to fig. 2, 11 and 21, as an embodiment, the blood sample analyzer 1 further includes a second sample preparation tube 49 and a third sample preparation tube 410, and the sample preparation control valve group 48 includes a second sample preparation control valve 481, a third sample preparation control valve 482 and a fourth sample preparation control valve 483. The second sample preparation tube 49 is connected between the second sample preparation control valve 481 and the flow chamber 4321, and the second sample preparation control valve 481 is connected between the second sample preparation tube 49 and the second reaction cell 4311. The third sample preparation tube 410 is connected between the second sample preparation control valve 481 and the flow chamber 4321, and the third sample preparation control valve 482 is connected between the third sample preparation tube 410 and the second reaction cell 4311. The fourth sample preparation control valve 483 is connected between the sample pushing power member and the second and third

sample preparation tubes

49, 410 for controlling the sample pushing power member to switch communication with one of the second and third

sample preparation tubes

49, 410, respectively. Here, taking the example of transferring the blood sample from the second reaction cell 4311 to the flow cell 4321, the preparation and sample pushing process of the optical detection channel sample will be described: first, the second sample preparation control valve 481 is controlled to open to conduct the second sample preparation tube 49 and the second reaction cell 4311, and then the blood sample in the second reaction cell 4311 is sucked to the second sample preparation tube 49 by the sample suction power means; and then the second sample preparation control valve 481 is controlled to close to disconnect the second sample preparation tube 49 from the second reaction cell 4311, and the fourth sample preparation control valve 483 is controlled to conduct the sample pushing power part and the second sample preparation tube 49, and finally the blood sample in the second sample preparation tube 49 is pushed into the flow chamber 4321 by the sample pushing power part.

Referring to fig. 2, 6 and 11, as an embodiment, the blood sample analyzer 1 further includes a dye liquor dosing assembly 50, and the dye liquor dosing assembly 50 is used for quantitative control of dye liquor reagents. The dye liquor dosing assembly 50 is arranged between the optical detection part 432 and the front plate 21, i.e. the dye liquor dosing assembly 50 is located in front of the optical detection part 432. The dye liquor dosing assembly 50 is located a distance from the top plate 24 less than the distance from the bottom plate 23.

As an embodiment, the dye liquor quantitative assembly 50 includes a dye liquor quantitative pump for providing driving force for dye liquor reagent quantitative, and a dye liquor quantitative sensor for detecting whether the dye liquor reagent passes and/or parameters such as flow rate, pressure and the like of the dye liquor reagent.

Referring to fig. 11 and 15, as an embodiment, the optical detecting member 432 and the dye liquor dosing module 50 are both mounted on the liquid path diaphragm 29 and are both located above the liquid path diaphragm 29, and the dye liquor dosing module 50 is located in front of the optical detecting member 432. The sample preparation control valve group 48, the optical detection reaction cell 431, and the hemoglobin detection unit 42 are all located below the liquid path partition 29.

Referring to fig. 1, 2 and 4, as an embodiment, the blood sample analyzer 1 further includes a dye reagent carrying assembly 60, and the dye reagent carrying assembly 60 is used for carrying the dye reagent container 2; the front shell 11 comprises a front shell body 112 and a door plate 113, a containing cavity and a third opening 1121 communicated with the containing cavity are formed between the front shell body 112 and the front plate 21 in a surrounding manner, and the door plate 113 is rotatably connected or detachably connected with the front shell body 112 for sealing or opening the third opening 1121; the dye reagent carrying assembly 60 is slidably mounted in the receiving chamber from the third opening 1121. In a specific application, after the door 113 is opened, a user or other operators can take out the dye liquor reagent bearing assembly 60 from the third opening 1121 to replace the dye liquor reagent container 2, and after replacement, the dye liquor reagent bearing assembly 60 can be placed into the accommodating cavity through the third opening 1121, so that replacement of the dye liquor reagent container 2 is convenient.

Referring to fig. 1, 4, 17 and 18, as an embodiment, the dye liquor reagent carrying assembly 60 includes a carrying portion 61, a first sliding portion 62 and a blocking piece 63, the carrying portion 61 is used for carrying the dye liquor reagent container 2, the first sliding portion 62 is disposed at the bottom of the carrying portion 61, and the blocking piece 63 is disposed at one end of the first sliding portion 62; the dye liquor reagent fixing assembly 70 is further arranged in the accommodating cavity, the dye liquor reagent fixing assembly 70 comprises a connecting portion 71, a second sliding portion 72 and two limiting buffer pieces 73, the first sliding portion 62 is slidably connected with the second sliding portion 72, the connecting portion 71 is arranged at one end of the second sliding portion 72 and is connected with the frame 20, and the two limiting buffer pieces 73 are respectively arranged close to two ends of the second sliding portion 72 and used for limiting the sliding stroke of the blocking piece 63. The two limiting buffer members 73 can limit the front and back of the baffle plates 63 on the dye liquor reagent bearing assembly 60 and play a role in buffering. In the present embodiment, the bearing portion 61 is a dye liquor rack, one of the first sliding portion 62 and the second sliding portion 72 is a first sliding rail, and the other is a second sliding rail or a sliding block that is matched with the first sliding block. In a specific application, after the door 113 is opened, a user or other operator can slide the dye reagent carrying assembly 60 by pushing and pulling to pull or push the dye reagent container 2 out of the blood sample analyzer 1, so that the dye reagent container 2 can be replaced conveniently.

As an embodiment, the dye liquor reagent container 2 is a dye liquor reagent bag, and the dye liquor reagent bag is hung in a groove of the dye liquor bracket. Of course, in a specific application, the dye liquor reagent container 2 may be a container such as a dye liquor reagent bottle or a dye liquor kit.

As an embodiment, the third opening 1121 is disposed on the right side of the front housing body 112, so that the dye liquor reagent carrying assembly 60 and the dye liquor quantifying assembly 50 can be located relatively close to each other, so as to facilitate reducing the waste of the dye liquor reagent during the replacement of the dye liquor reagent container 2.

In one embodiment, the stopper buffer 73 is a magnet, and the blocking piece 63 is a magnetic metal piece. The magnet can be sleeved with a plastic column which can limit the baffle 63 on the dye liquor reagent bearing assembly 60 back and forth and play a role in buffering. Of course, in a specific application, the positioning manner of the limiting buffer member 73 is not limited thereto, and for example, in an alternative embodiment, the limiting buffer member 73 may be an elastic member such as a spring or a shrapnel.

Referring to fig. 4, 13 and 14, as one embodiment, the sampling assembly 30 includes a sampling needle 31, a sample suction line 33 connected to the sampling needle 31, and a movement driving device 32 for driving the movement of the sampling needle 31. A movement drive 32 is connected to the sampling needle 31 for driving the sampling needle 31 in a predetermined direction in a spatial dimension such that the sampling needle 31 is moved to different working positions, e.g. sampling position, sample dividing position, etc.

Referring to fig. 4, 11 and 13, as an embodiment, the blood sample analyzer 1 forms an open sampling site under the front case 11, and the first reaction cell 421, the second reaction cell 4311 and the third reaction cell 4312 form one sample dividing site, respectively. The open sampling position, the first reaction tank 421, the second reaction tank 4311 and the third reaction tank 4312 are sequentially arranged from front to back along a straight track, namely, the open sampling position, the first reaction tank 421, the second reaction tank 4311 and the third reaction tank 4312 are arranged in a straight line and form a sampling and sample dividing track which extends in a straight line, so that the sampling needle 31 can realize sampling and sample dividing only by one reciprocating motion in the horizontal direction, the structure of the sampling assembly 30 is facilitated to be simplified, the volume and the cost of the sampling assembly 30 are effectively reduced, and the structural compactness of the blood sample analyzer 1 is facilitated to be improved.

Referring to fig. 14, as an embodiment, the motion driving device 32 includes a lift driving mechanism 321 and a horizontal driving mechanism 322, wherein the lift driving mechanism 321 is used for driving the sampling needle 31 to perform a lifting motion, and the horizontal driving mechanism 322 is used for driving the sampling needle 31 and the lift driving mechanism 321 to perform a linear reciprocating motion along a sampling and sample dividing track. Of course, the setting mode of the motion driving device 32 is not limited to this, and in a specific application, the motion driving device 32 may be designed to be a device capable of driving the sampling needle 31 to perform three-dimensional motion according to the design requirement of the sampling and sample dividing track; the movement driving device 32 is not limited to the linear movement mechanism, and for example, a combination of a swing arm rotation mechanism and a lifting mechanism may be employed.

As one embodiment, the elevation driving mechanism 321 includes a vertical guide rail and an elevation power member for driving the sampling needle 31 to move along the vertical guide rail, and the horizontal driving mechanism 322 includes a lateral guide rail and a horizontal power member for driving the elevation driving mechanism 321 to move along the lateral guide rail.

Referring to fig. 2, 4 and 14, as an embodiment, the blood sample analyzer 1 further includes a swab 80 provided on a vertical rail for wiping the outer wall of the sampling needle 31.

Referring to fig. 2, 11 and 14, as an embodiment, the blood sample analyzer 1 further includes a swab cleaning filter 90, where the swab cleaning filter 90 is connected to the swab 80 through a pipeline, and the swab cleaning filter 90 is disposed between the first reaction tank 421 and the front plate 21, so that the structure of the blood sample analyzer 1 can be made compact by adopting this layout.

Referring to fig. 2 and 21, as an embodiment, the blood sample analyzer 1 further includes a blood sedimentation detection assembly 101, a portion of the sample suction line 33 is used as a blood sedimentation detection tube section for providing a blood sample with a blood sedimentation detection site, and the blood sedimentation detection assembly 101 is disposed beside the blood sedimentation detection tube section for performing blood sedimentation detection on the blood sample in the blood sedimentation detection tube section. The blood sedimentation detection assembly 101 may obtain information on the rate or extent of aggregation of red blood cells by performing light absorption or light scattering measurements on the blood sample in the blood sedimentation detection tube segment to convert the value of the cell sedimentation rate (Erythrocyte sedimentation rate, ESR). In this embodiment, the blood sample analyzer 1 integrates the blood sedimentation detecting function and the blood routine detecting function, and the blood sedimentation detecting tube section is a part of the sample suction line 33, without separately setting the layout space for the blood sedimentation sample and the detection, effectively simplifying the structure and reducing the layout space.

As one embodiment, the blood sedimentation detection assembly 101 is disposed on a vertical rail or a lateral rail of the sampling assembly 30.

Referring to fig. 2, 5, 7 and 21, as an embodiment, the blood sample analyzer 1 further includes a first syringe 102 and a second syringe 103, the first syringe 102 being used for driving the sampling assembly 30 to aspirate the blood sample and for driving the sampling assembly 30 to dispense the aspirated blood sample to the blood routine detection assembly 40, and further being used for providing a driving force for sample pushing of the blood sample in the sample preparation line; the second syringe 103 is used to provide a driving force for the diluent into the blood routine testing assembly 40 and for sample preparation for the blood sample into the sample preparation line. In this embodiment, the liquid path driving part of the blood routine detecting component 40 has only two syringes, and by time-sharing multiplexing the two syringes, the cost and the volume of the apparatus can be greatly reduced, which is beneficial to realizing the low cost and miniaturized design of the blood sample analyzer 1. Specifically, the first syringe 102 is used to power sampling, sample dispensing (i.e., blood dispensing), and pushing; the second syringe 103 is used for realizing other liquid path driving functions except the driving of the first syringe 102, and mainly comprises the functions of cleaning the sample flowing through the sample position, filling the impedance sheath liquid pool 46, optically detecting sheath pushing liquid and the like for diluting the sample, preparing the reaction tank/sampling channel/sample and the like, and supplying power for all the transportation and sample preparation related to the diluent.

As one embodiment, the first syringe 102 driving the sampling assembly 30 to aspirate a blood sample includes: the first syringe 102 drives the sampling needle 31 to draw a blood sample from a sample container for loading the blood sample, and stores the blood sample in the sampling needle 31 and the sampling tube 33.

As one embodiment, the first syringe 102 driving the sampling assembly 30 to dispense the aspirated blood sample to the blood routine testing assembly 40 includes: pumping part of the blood sample stored in the sampling needle 31 and the sampling tube 33 to a blood sedimentation detection tube section for detection by the blood sedimentation detection assembly 101; dispensing a portion of the blood sample stored in the sampling needle 31 and the sampling tube 33 to the first reaction cell 421 to prepare a blood sample for impedance count detection and a blood sample for hemoglobin detection in the first reaction cell 421; dispensing a part of the blood sample stored in the sampling needle 31 and the sampling tube 33 to the second reaction cell 4311 to prepare a blood sample for detecting leukocyte parameters in the second reaction cell 4311, and dispensing the blood sample to the second reaction cell 4311; a part of the blood sample stored in the sampling needle 31 and the sampling tube 33 is dispensed to the third reaction cell 4312 to prepare a blood sample for detecting reticulocyte parameters in the second reaction cell 4311.

As one embodiment, the first syringe 102 is a microliter-scale syringe and the second syringe 103 is a milliliter-scale syringe. As a preferred embodiment of the present example, the first syringe 102 has a range of 250uL and the second syringe 103 has a range of 10mL.

As one embodiment, the first syringe 102 and the second syringe 103 are driven by separate power mechanisms. Specifically, the blood sample analyzer 1 further includes a first motor for driving the first syringe 102 to act and a second motor for driving the second syringe 103 to act, where the first motor and the second motor are two motors that are set independently of each other. The step size of the second motor is preferably larger than the step size of the first motor.

Referring to fig. 5 and 15, as an embodiment, the first syringe 102 is provided to the front plate 21, and the distance from the first syringe 102 to the first side 25 is smaller than the distance to the second side 26, i.e., the first syringe 102 is provided near the left side of the front plate 21.

Referring to fig. 7 and 15, as one embodiment, the second syringe 103 is disposed adjacent the first side 25 and the first syringe 102 is disposed a smaller distance from the front plate 21 than the rear plate 22, i.e., the second syringe 103 is disposed near the front of the left side of the frame 20.

Referring to fig. 7, 15 and 16, as an embodiment, the second syringe 103 is provided on the first side plate 28, and the second syringe 103 is provided near the front side of the first side plate 28. By adopting the layout mode, the second injector 103 and the diluent reservoir 204 can be positioned on the first side plate 28, which is beneficial to reducing the length of a connecting pipeline between the second injector 103 and the diluent reservoir 204.

Referring to fig. 2, 5 and 20, as an embodiment, the blood sample analyzer 1 further includes a manifold plate 104 and a sampling control valve set 105, the sampling control valve set 105 is mounted on the manifold plate 104, and the sampling control valve set 105 is connected to the first syringe 102 through the manifold plate 104 for controlling the first syringe 102 to switch on the sampling assembly 30, the blood routine detection assembly 40 and the diluent reservoir 204, respectively. The sampling control valve group 105 integrates the flow channel inside the confluence plate 104, thereby being beneficial to reducing the production of connecting pipelines and bubbles and improving the structural compactness of products.

Referring to fig. 5 and 20, as an embodiment, the manifold plate 104 and the first injector 102 are mounted on the front plate 21, so that the positions of the manifold plate 104, the sampling control valve group 105 and the first injector 102 can be relatively close, thereby facilitating the reduction of the length of the connecting pipeline and the reduction of the generation of bubbles.

Referring to fig. 5, 15 and 20, as one embodiment, the distance from the bus plate 104 to the first side 25 is smaller than the distance to the second side 26, the inlet and outlet of the first syringe 102 are disposed upward, and the bus plate 104 is located between the first syringe 102 and the top plate 24. The first syringe 102 is less distant from the first side section 25 than the second side section 26. In this embodiment, the bus plate 104 is disposed near the upper left portion of the front plate 21, and the first injector 102 is disposed near the lower left portion of the front plate 21, so that the bus plate 104 is disposed near the inlet and outlet of the first injector 102 in this layout manner, which is beneficial to improving the compactness of the product.

Referring to fig. 20 and 21, as one embodiment, the sampling control valve group 105 includes a first control valve 1051, a second control valve 1052, a third control valve 1053, and a fourth control valve 1054. The first control valve 1051 is a sampling channel and a sample pushing channel switching valve, and is used for controlling the first injector 102 to switch on the sampling assembly 30 and the blood routine detection assembly 40 respectively so as to realize the switching of the sampling channel and the sample pushing channel. The second control valve 1052 is a sampling channel purge valve for controlling the first syringe 102 to switch through the sampling assembly 30 and the diluent reservoir 204, respectively, to effect purging of the sampling assembly 30. The third control valve 1053 is an optical detection sample pushing channel and impedance sample pushing channel switching valve, and is used for controlling the first injector 102 to switch on the optical detection component 43 and the impedance counting detection component 41 respectively so as to switch the optical sample pushing channel and the impedance sample pushing channel, and the fourth control valve 1054 is an injector filling valve, and is used for controlling the diluent reservoir 204 to fill the diluent into the first injector 102.

Referring to fig. 2 and 21, as an embodiment, the blood sample analyzer 1 further includes a diluent switching valve 106, an optical sheath fluid transfer line 107, and an optical sheath fluid control valve 108, wherein three ports of the diluent switching valve 106 are connected to the second syringe 103, the diluent reservoir 204, and the optical sheath fluid transfer line 107, respectively, the optical sheath fluid transfer line 107 is connected between the flow chamber 4321 and the diluent switching valve 106, the optical sheath fluid control valve 108 is provided in the optical sheath fluid transfer line 107, the second control valve 1052, the impedance sheath fluid reservoir 46, the first reaction tank 421, the second reaction tank 4311, the third reaction tank 4312, and the first syringe 102 are connected to the optical sheath fluid transfer line 107 through lines, and the connection portion 71 is located between the diluent switching valve 106 and the optical sheath fluid control valve 108, so that each branch of the second control valve 1052, the impedance sheath fluid reservoir 46, the first reaction tank 421, the second reaction tank 4311, and the third reaction tank 4312, and the first syringe 102 is connected to each branch of the normally closed end of the diluent switching valve 106, thereby reducing air bubbles in each branch of the lines.

Referring to fig. 2 and 5, as an embodiment, the blood sample analyzer 1 further includes a hydraulic pressure detection assembly 109 for detecting a pressure parameter, the hydraulic pressure detection assembly 109 is mounted on the front plate 21, and the hydraulic pressure detection assembly 109 is connected between the first syringe 102 and the manifold plate 104 through a pipe. The hydraulic pressure detection assembly 109 is specifically configured to detect the pressure on the line between the inlet and outlet of the first syringe 102 and the manifold plate 104.

Referring to fig. 5, as an embodiment, the hydraulic pressure detecting unit 109 is disposed near the first syringe 102 and the bus plate 104, so that the hydraulic pressure detecting unit 109 is relatively close to the connecting line between the inlet and outlet of the first syringe 102 and the bus plate 104.

Referring to fig. 5 and 15, as an embodiment, the hydraulic pressure detection assembly 109 is located on the side of the bus plate 104 facing the first side 25, that is, the hydraulic pressure detection assembly 109 is located on the left side of the bus plate 104 in the horizontal direction, so that the structural layout is compact, and the distance between the hydraulic pressure detection assembly 109 and the inlet and outlet of the first injector 102 and the bus plate 104 can be relatively short. Of course, in a specific application, the placement of the hydraulic pressure detection assembly 109 is not limited to this, and for example, as an alternative embodiment, the hydraulic pressure detection assembly 109 is located between the first injector 102 and the bus plate 104, that is, the hydraulic pressure detection assembly 109 is located between the first injector 102 and the bus plate 104 in the vertical direction, which is also compact, and the distance between the inlet and outlet of the first injector 102 and the bus plate 104 of the hydraulic pressure detection assembly 109 may be relatively short.

Referring to fig. 3 and 9, as an embodiment, the blood sample analyzer 1 further includes a liquid path inlet and outlet interface assembly 201, the liquid path interface assembly includes a diluent inlet, a hemolysis agent inlet, and a waste liquid outlet, the reagent interface assembly is mounted on the rear plate 22, and the reagent interface assembly is located between the first side 25 and the middle partition 27, and a distance from the reagent interface assembly to the bottom plate 23 is smaller than a distance from the top plate 24. The fluid access interface assembly 201 is disposed behind and below the housing 20 such that the fluid access interface assembly 201 is facing away from the user, which is advantageous in that the fluid access interface assembly 201 does not affect the visual aesthetics of the blood sample analyzer 1.

Referring to fig. 3 and 9, as an embodiment, the fluid path interface assembly includes two diluent inlets, two hemolysis agent inlets, and a waste fluid inlet, where the two diluent inlets are DR diluent inlet 2011 and DS diluent, respectively, and DR diluent inlet 2011 is an inlet for diluent used in RET channel (i.e., reticulocyte parameter detection channel). The two hemolytic agent inlets are respectively an LD hemolytic agent inlet 2012 and an LH hemolytic agent inlet 2013, wherein the LD hemolytic agent inlet 2012 is an inlet of a hemolytic agent used by a DIFF channel (namely a leukocyte parameter detection channel), and the LH hemolytic agent inlet 2013 is an inlet of a hemolytic agent used by an HGB channel (namely a hemoglobin detection channel). Of course, in specific applications, the number of diluent inlets, hemolyzing agent inlets and waste liquid outlets included in the liquid path interface assembly is not limited thereto,

referring to fig. 3 and 9, DR diluent inlet 2011, LD hemolytic agent inlet 2012, LH hemolytic agent inlet 2013, DS diluent inlet 2014, and waste liquid outlet 2015 are arranged in this order from top to bottom as one embodiment. Of course, in specific applications, the arrangement of DR diluent inlet 2011, LD hemolytic agent inlet 2012, LH hemolytic agent inlet 2013, DS diluent inlet 2014, and waste liquid outlet 2015 is not limited thereto.

Referring to fig. 3, 7 and 8, as an embodiment, the blood sample analyzer 1 further includes a liquid detection assembly 202, and the liquid detection assembly 202 includes a diluent detection component and a hemolysis agent detection component, where the diluent detection component is in communication with the diluent inlet for determining whether a diluent passes through the diluent inlet; the hemolytic agent detecting member communicates with the hemolytic agent inlet for determining whether the hemolytic agent passes through the hemolytic agent inlet. The liquid detection assembly 202 is mounted on the first side panel 28 with the liquid detection assembly 202 being less distant from the back panel 22 than from the front panel 21 and the liquid detection assembly 202 being less distant from the bottom panel 23 than from the top panel 24. In this embodiment, the liquid detection assembly 202 is disposed below and behind the first side plate 28, which is beneficial to making the liquid detection assembly 202 and the liquid path interface assembly relatively close to each other, and has a compact structure.

As an embodiment, the liquid detection assembly 202 includes two diluent detection components and two hemolysis agent detection components, wherein the two diluent detection components are a DR diluent detection component and a DS diluent detection component, respectively, the DR diluent detection component is connected to the DR diluent inlet 2011, and the DS diluent detection component is connected to the DS diluent inlet 2014. The two hemolytic agent detection components are respectively an LD hemolytic agent detection component and an LH hemolytic agent detection component, the LD hemolytic agent detection component is connected with the LD hemolytic agent inlet 2012, and the LH hemolytic agent detection component is connected with the LH hemolytic agent inlet 2013. In a specific application, the number of the diluent detecting parts and the hemolytic agent detecting parts can be correspondingly designed according to the diluent inlet and the hemolytic agent inlet.

Referring to fig. 3, 7 and 12, as an embodiment, the blood sample analyzer 1 further includes a dosing pump assembly 203, the dosing pump assembly 203 including a diluent dosing pump for delivering an external dosing diluent into the blood sample analyzer 1 and/or a hemolysis agent dosing pump for delivering an external dosing hemolysis agent into the blood sample analyzer 1, the dosing pump assembly 203 being mounted on the frame 20 and being disposed adjacent to the rear plate 22, the rear plate 22 being provided with a second opening 221 for facilitating the removal and mounting of the dosing pump assembly 203. In a specific application, after the rear housing 12 is removed, the dosing pump assembly 203 can be overhauled and maintained through the second opening 221. The dosing pump assembly 203 is arranged close to the rear plate 22, so that the distance between the dosing pump assembly 203 and the diluent inlet and the hemolytic agent inlet is relatively short, the length of a connecting pipeline is reduced, and the dosing pump assembly 203 can be conveniently installed and detached. Of course, in a specific application, as an alternative embodiment, the fixed displacement pump assembly 203 may be mounted by a bracket, and the fixed displacement pump assembly 203 may be removed from the front side of the first side plate 28.

As an embodiment, the dosing pump assembly 203 includes a diluent dosing pump for dosing diluent from the external diluent tank to the diluent reservoir 204, a first hemolytic agent dosing pump for dosing a first hemolytic agent (i.e., LH hemolytic agent) from the first external hemolytic agent container to the first reaction tank 421 (i.e., HGB tank) of the hemoglobin detection assembly 42, and a second hemolytic agent dosing pump for dosing a second hemolytic agent (i.e., LD hemolytic agent) from the second external hemolytic agent container to the second reaction tank 4311 (i.e., DIFF tank) of the optical detection assembly 43, as one embodiment.

Referring to fig. 12, 15 and 16, as an embodiment, the dosing pump assembly 203 is mounted on the first side plate 28, and the distance from the dosing pump assembly 203 to the bottom plate 23 is smaller than the distance from the top plate 24, that is, the dosing pump assembly 203 is disposed near the rear lower side of the first side plate 28, so that the dosing pump can discharge bubbles conveniently, and the space can be fully utilized.

Referring to fig. 7, as an embodiment, the dosing pump assembly 203 is located between the liquid detection assembly 202 and the bottom plate 23, i.e., the dosing pump assembly 203 is located below the liquid detection assembly 202.

Referring to fig. 12 and 16, as an embodiment, the dosing pump assembly 203 is positioned between the first side plate 28 and the middle barrier 27, so that the later disassembly and maintenance of the dosing pump assembly 203 can be facilitated.

Referring to fig. 3, 7, 12 and 16, as an embodiment, the blood sample analyzer 1 further includes a diluent reservoir 204, the diluent reservoir 204 is mounted on the first side plate 28, and the distance from the diluent reservoir 204 to the rear plate 22 is smaller than the distance to the front plate 21, the diluent reservoir 204 being located between the top plate 24 and the liquid detection assembly 202. The diluent reservoir 204 is also referred to as a diluent heating reservoir and may be used to both store diluent and heat diluent. In this embodiment, the diluent reservoir 204 is located in the rear side region of the first side plate 28 along the front-rear direction of the blood sample analyzer 1, so that the diluent reservoir 204 is close to the diluent inlet and the hemolytic agent inlet, thereby facilitating the assurance of the temperatures of the diluent and the hemolytic agent.

Referring to fig. 3, 7 and 16, as an embodiment, the blood sample analyzer 1 further includes a waste liquid tank 205 and a waste liquid pump assembly 206, both of which are mounted on the first side plate 28, with the waste liquid tank 205 being located between the waste liquid pump assembly 206 and the bottom plate 23, the waste liquid pump assembly 206 being located between the top plate 24 and the waste liquid tank 205, the liquid detection assembly 202 being located between the back plate 22 and the waste liquid tank 205, and the diluent liquid reservoir 204 being located between the back plate 22 and the waste liquid pump assembly 206. The waste liquid pool 205 is located in the bottom region of the first side plate 28 in the height direction of the blood sample analyzer 1, so that the waste liquid pool 205 can collect the waste liquid discharged from the optical detection module 43 and the hemoglobin detection module 42 better. The waste pump assembly 206 is above the waste reservoir 205, which may allow the waste pump assembly 206 to be closer to the waste reservoir 205.

Referring to fig. 7, 11 and 16, as an embodiment, a waste liquid valve assembly 207 is further installed on the first side plate 28, and the waste liquid valve assembly 207 is located at a side of the waste liquid pool 205 facing the rear plate 22, and the waste liquid valve assembly 207 is located at a relatively short distance from the waste liquid pool 205. The waste liquid valve assembly 207 is located at the bottom area of the first side plate 28, and is closer to the first reaction tank 421, the second reaction tank 4311 and the third reaction tank 4312, so that better liquid draining is facilitated.

Referring to fig. 7 and 8, as an embodiment, the first side plate 28 is further provided with a diluent metering liquid valve, a diluent metering gas valve, a hemolysis agent metering liquid valve, and a hemolysis agent metering pump gas valve, where the diluent metering liquid valve, the diluent metering gas valve, and the hemolysis agent metering pump gas valve are located between the diluent reservoir 204 and the liquid detection component 202, and the hemolysis agent metering liquid valve is located between the waste liquid reservoir 205 and the liquid detection component 202. The diluent metering valve and the hemolysis agent metering valve are positioned above the metering pump assembly 203, so that air bubbles can be conveniently discharged. The diluent quantitative air valve and the hemolytic agent quantitative pump air valve are arranged at a position close to the quantitative pump assembly 203, which is beneficial to reducing the air consumption.

Referring to fig. 7 and 8, as an embodiment, the diluent metering valve includes a DR diluent metering valve 208, the diluent metering valve includes a DR diluent metering valve 2081, the hemolysis agent metering valve includes an LD hemolysis agent metering valve 2082 and an LH hemolysis agent metering valve 2083, the hemolysis agent metering pump valve includes an LD hemolysis agent metering valve 2084 and an LH hemolysis agent metering valve 2085, and the waste liquid valve assembly 207 includes a RET Chi Feiye valve 2071, a DIFF Chi Feiye valve 2072, a swab waste liquid valve 2073, and an HGB Chi Feiye valve 2074. The LD hemolytic agent quantitative liquid valve 2082, the DR diluent quantitative liquid valve 208, the LD hemolytic agent quantitative gas valve 2084, the DR diluent quantitative gas valve 2081, the LH hemolytic agent quantitative gas valve 2085, the RET Chi Feiye valve 2071, and the DIFF Chi Feiye valve 2072 are located between the liquid detection assembly 202 and the diluent reservoir 204 in a vertical direction, and are sequentially arranged in a horizontal direction from back to front along the blood sample analyzer 1. The swab waste liquid valve 2073, the HGB Chi Feiye valve 2074 and the LH hemolytic agent dosing liquid valve 2083 are sequentially arranged from top to bottom in the height direction of the blood sample analyzer 1, and the swab waste liquid valve 2073 is horizontally positioned between the waste liquid pool 205 and the DIFF Chi Feiye valve 2072, and the HGB Chi Feiye valve 2074 and the LH hemolytic agent dosing liquid valve 2083 are horizontally positioned between the waste liquid pool 205 and the liquid detection assembly 202.

Referring to fig. 3, 7, 11 and 16, as an embodiment, the blood sample analyzer 1 further includes a gas chamber 209, a control valve assembly 301 and an isolation chamber 302, the isolation chamber 302 is used for isolating waste liquid from the air pressure sensor, the gas chamber 209, the control valve assembly 301 and the isolation chamber 302 are all mounted on the first side plate 28, the gas chamber 209, the control valve assembly 301 and the isolation chamber 302 are sequentially arranged along the direction of the rear plate 22 toward the front plate 21, the gas chamber 209 is disposed between the diluent reservoir 204 and the top plate 24, and the control valve assembly 301 is disposed between the waste liquid pump assembly 206 and the top plate 24. The air chamber 209 is disposed in an upper region of the first side plate 28, which can facilitate preventing liquid from entering the air chamber 209. The control valve assembly 301 includes a control liquid valve assembly mainly including a liquid valve for a diluent channel inside the blood sample analyzer 1, and a control gas valve assembly mainly including a gas valve on a gas path of the dosing pump, a gas valve on a gas path of the impedance sheath liquid pool 46, and the like.

As one embodiment, two isolation chambers 302 are provided, and the two isolation chambers 302 are a reaction tank waste liquid channel isolation chamber 302 and a waste liquid tank 205 gas path isolation chamber 302, respectively, and the reaction tank waste liquid channel isolation chamber 302 is used for isolating waste liquid in a reaction tank waste liquid channel from a gas pressure sensor; the waste liquid pool 205 gas path isolation chamber 302 is used for isolating waste liquid on the gas path of the waste liquid pool 205 from the gas pressure sensor.

Referring to fig. 1, 3, 4 and 15, as an embodiment, the blood sample analyzer 1 further includes an air pressure detection circuit board 303, where the air pressure detection circuit board 303 is located between the front plate 21 and the housing 10, that is, the air pressure detection circuit board 303 is located in a space formed by enclosing the front plate 21 and the front shell 11, and in this layout manner, the structural compactness of the blood sample analyzer 1 is improved.

As one embodiment, the air pressure detection circuit board 303 is disposed near the top end of the front plate 21. The air pressure sensor is connected to the air pressure detection circuit board 303. The air pressure sensor is connected to the isolation chamber 302. In this embodiment, the air pressure detecting circuit board 303 is disposed on the top of the frame 20, which is beneficial to prevent the liquid in the liquid path from entering the air pressure sensor.

Referring to fig. 1, 2, 4 and 11, as an embodiment, the blood sample analyzer 1 further includes a rfid reader 304 and a shielding assembly 305 for covering the impedance detection circuit board 412, the rfid reader 304 and the shielding assembly 305 are disposed between the housing 10 and the impedance detection circuit board 412, and the shielding assembly 305 is disposed between the rfid reader 304 and the impedance detection circuit board 412. The RFID reader 304 is an RFID reader for reading a rf reagent card for loading a reagent. The shielding assembly 305 is used primarily to shield and protect the impedance sensing circuit board 412.

As one example, the RFID reader 304 may be mounted to the shield assembly 305, although the RFID reader 304 may be attached to other components in a particular application.

Referring to fig. 2, 4 and 6, as an embodiment, the blood sample analyzer 1 further includes an RFID antenna 306 and an antenna support, the antenna support is disposed on the front plate 21 near the second side 26, and the RFID antenna 306 is mounted on the antenna support, so that the RFID antenna 306 is located on the right side of the RFID reader 304, and the distance between the RFID antenna 306 and the RFID reader 304 can be relatively short, and the structure is relatively compact.

Referring to fig. 3, 9 and 19, as an embodiment, the blood sample analyzer 1 further includes a power supply assembly 307, the power supply assembly 307 includes a mounting case 3071, a power supply 3072 and a first heat radiation fan 3073, the mounting case 3071 is mounted to the rear plate 22, and the mounting case 3071 is formed with an inner cavity, an air inlet 3074 communicating with the inner cavity, and an air outlet 3075 communicating with the inner cavity; the power source 3072 is arranged in the inner cavity; the first cooling fan 3073 is disposed at the air inlet 3074 or the air outlet 3075. In this embodiment, an independent heat dissipation air channel is provided for the power source 3072, so that the interference of the heat dissipation of the power source 3072 on the blood routine detection component 40 can be avoided.

Referring to fig. 4, 6 and 9, as an embodiment, the top of the mounting case 3071 is further formed with a wire outlet 3076 provided toward the top plate 24 for wire to pass through. The outlet 3076 extends upward from the top of the mounting case 3071, which is beneficial to realizing connection of wires between the power source 3072 and the first cooling fan 3073 and the circuit board assembly 308, and since the liquid path interface of the optical detection component 432 is located at the left side of the optical detection component 432 (i.e. the side of the optical detection component 432 facing the middle partition plate 27), the influence of the liquid path of the optical detection component 432 on the outlet of the power source assembly 307 can be avoided, thereby being beneficial to improving the reliability of the liquid-electric separation.

Referring to fig. 3 and 9, as an embodiment, the power module 307 further includes a power switch 3077 and a power socket 3078, and both the power switch 3077 and the power socket 3078 are mounted on the mounting case 3071. The power switch 3077 activates a control switch for the power source 3072 of the blood sample analyzer 1, and the power socket 3078 is used for connecting a cable so that an external power supply part can supply power to the blood sample analyzer 1.

Referring to fig. 3 and 9, as an embodiment, the blood sample analyzer 1 further includes a second heat radiation fan 401, the second heat radiation fan 401 being a main heat radiation fan of the blood sample analyzer 1, the second heat radiation fan 401 being configured to radiate heat from the device parts in the housing 20.

Referring to fig. 3, 4, 10 and 15, as an embodiment, the blood sample analyzer 1 further includes a circuit board assembly 308, the circuit board assembly 308 is mounted on the top plate 24, and the circuit board assembly 308 is located above the top plate 24, and the blood routine detection assembly 40 and the sampling assembly 30 are located below the top plate 24.

Referring to fig. 4, 10 and 15, as an embodiment, the circuit board assembly 308 includes a main control board 3081 and a motherboard 3082, and the main control board 3081 is stacked above the motherboard 3082. The main control board 3081 is mainly used for providing a USB port, a network port, a display interface, a touch screen interface, a loudspeaker interface and data processing and operation functions. Motherboard 3082 is primarily used for: a power 3072 module output; communication of other boards such as an optical signal board, an impedance signal board, an RFID board and the like; driving power components such as a motor, a valve, a pump and the like; and detecting signals such as temperature, pressure, optical couplers and the like. In the embodiment, different functions are respectively designed on different circuit boards, so that the volume of the circuit boards is reduced; of course, in a specific application, the arrangement of the circuit board assembly 308 is not limited thereto, and for example, as an alternative embodiment, the circuit board assembly 308 may be designed by integrating the main control board 3081 and the motherboard 3082 into one circuit board, or dividing the circuit board assembly 308 into more than three circuit boards.

Referring to fig. 3, 4, 10 and 15, as an embodiment, the blood sample analyzer 1 further includes an air pump 309, the air pump 309 is mounted on the top plate 24, and the air pump 309 is located above the top plate 24. In this embodiment, the air pump 309 is disposed above the top plate 24 and at the same height as the circuit board assembly 308, so that, on one hand, liquid in the liquid path is prevented from entering the air pump 309, and on the other hand, condensed water possibly existing may be prevented from entering the air pump 309.

As an embodiment, the blood sample analyzer 1 further includes a positive pressure air source and a negative pressure air source, the quantitative determination of each reagent of the blood routine detection assembly 40 is performed by using a quantitative pump, and each quantitative pump is driven to act by the positive pressure air source and the negative pressure air source. In this embodiment, by designing the power source for driving the reagent delivery for the blood routine detection module 40 to be a solution in which the positive pressure air source and the negative pressure air source are respectively matched with the constant delivery pumps (for example, the constant delivery pump for optical detection and the constant delivery pump for hemoglobin detection), the design of large air consumption components with large air consumption or high output pressure such as pneumatic pressure break valves and air cylinders is omitted, so that the average air consumption of the blood cell analyzer is controlled within a predetermined range in one detection period for completing hemoglobin detection, impedance counting detection and optical detection, the air consumption requirement of the blood sample analyzer 1 is greatly reduced, the volume and cost of the pneumatic part are reduced, and the miniaturization and low cost design of the blood sample analyzer 1 are facilitated.

As one embodiment, the blood sample analyzer 1 has an average gas consumption of less than or equal to 2.0L/min during a test period in which the blood routine testing assembly 40 completes all testing items of a blood sample. The present embodiment proposes a low-cost and miniaturized design scheme of a micro air path system, in which the pneumatic pressure break valve, the air cylinder, the positive and negative pressure of the diluent reservoir 204 are cancelled, and the air path with larger air consumption or high output pressure (the working pressure of the air cylinder and the pneumatic pressure break valve is high) is needed, and the pneumatic driving scheme of the quantitative pump is mainly considered, so that the requirement on the pneumatic quantitative pump is reduced, namely, in the blood sample analyzer 1 provided in this embodiment, the main air consumption component is the quantitative pump.

As an implementation mode, the positive pressure output by the positive pressure air source is smaller than or equal to 90kpa, the negative pressure output by the negative pressure air source is larger than or equal to-30 kpa, namely in the implementation mode, the positive pressure working requirement of the air path system can be met by the positive pressure smaller than or equal to 90kpa, and the negative pressure working requirement of the air path system can be met by the negative pressure larger than or equal to-30 kpa, so that the working pressure required to be provided is lower, and therefore a miniature pump with miniaturization and extremely low cost can be selected for supporting realization, and meanwhile, a complicated tempering and adjusting system is not required, so that the miniature design of the air path system is conveniently realized, and the purposes of low cost and miniaturization of the blood sample analyzer 1 are achieved.

The preferred embodiment of the present example provides the blood sample analyzer 1, which realizes a layout design of low cost and miniaturization while also considering the convenience of operation and maintenance for the user, and the overall layout structure is highly integrated. Specifically, the embodiment adopts the scheme of high multiplexing of two syringes and the design scheme of a micro air path system, so that the cost and the volume of the blood sample analyzer 1 are greatly reduced; in addition, in this embodiment, each detection component of the samples such as the impedance counting detection component 41, the hemoglobin detection component 42, the optical detection component 43 and the like is disposed on the right half portion of the frame 20, and most of liquid path components such as a control valve, a liquid pump, a dosing pump, an injector and the like are disposed on the left side and the front side of the frame 20, so that the modular layout is facilitated to facilitate assembly and maintenance.

The foregoing description is only of the preferred embodiments of the present invention and is not intended to limit the scope of the invention, and all equivalent structural changes made by the description of the present invention and the accompanying drawings or direct/indirect application in other related technical fields are included in the scope of the invention.

Claims

1. A blood sample analyzer, characterized by: comprises a shell, a frame, a sampling component and a blood routine detection component;

the blood routine detection assembly is arranged on the rack and comprises an impedance counting detection assembly, the impedance counting detection assembly is used for detecting red blood cell parameters and/or platelet parameters of a blood sample, the impedance counting detection assembly comprises an impedance counting detection component and an impedance detection circuit board electrically connected with the impedance counting detection component, the impedance counting detection component is arranged between the front board and the rear board, the impedance counting detection component is adjacent to or abutted to the front board, and the impedance detection circuit board is arranged on one side of the impedance counting detection component, which is opposite to the rear board.

2. The blood sample analyzer of claim 1, wherein: the front plate is provided with a first opening in a penetrating mode, and the first opening is opposite to the impedance detection circuit board and is used for providing an avoidance space for installation and detachment of the impedance detection circuit board on the impedance counting detection component.

3. The blood sample analyzer of claim 2, wherein: the impedance detection circuit board at least partially penetrates through the first opening; or alternatively, the process may be performed,

the impedance detection circuit board is positioned between the first opening and the impedance counting detection component, and the first opening can be penetrated by the impedance detection circuit board; or alternatively, the process may be performed,

the first opening is located between the impedance detection circuit board and the impedance count detection component.

4. A blood sample analyzer according to any one of claims 1 to 3, wherein: the impedance count detecting means has a distance from the bottom plate smaller than a distance from the top plate; and/or the number of the groups of groups,

the impedance count detecting unit is mounted on the base plate.

5. A blood sample analyzer according to any one of claims 1 to 3, wherein: the blood sample analyzer further comprises a radio frequency identification card reader and a shielding component for covering the impedance detection circuit board, wherein the radio frequency identification card reader and the shielding component are both arranged between the shell and the impedance detection circuit board, and the shielding component is arranged between the radio frequency identification card reader and the impedance detection circuit board.

6. The blood sample analyzer of claim 1, wherein: the blood routine testing assembly further includes a hemoglobin testing assembly, the hemoglobin testing assembly including;

a first reaction cell for preparing a blood sample into a blood sample for hemoglobin detection and for preparing a blood sample for impedance detection, the first reaction cell being disposed close to the impedance count detection member, and a distance from the first reaction cell to the front plate being smaller than a distance from the first reaction cell to the rear plate;

and the hemoglobin detection part is arranged on the periphery of the first reaction tank and is used for detecting the hemoglobin parameters of the blood sample in the first reaction tank.

7. The blood sample analyzer of claim 6, wherein: the blood sample analyzer further comprises a first sample preparation control valve connected between the first reaction tank and the impedance count detection component through a pipeline, and the first sample preparation control valve is arranged close to the bottom of the first reaction tank; and/or the number of the groups of groups,

the blood sample analyzer further includes a swab cleaning filter disposed between the first reaction well and the front plate.

8. The blood sample analyzer of claim 6, wherein: the blood sample analyzer further comprises a rotating connecting plate, an impedance sheath fluid pool and an impedance sheath fluid control valve bank, wherein the rotating connecting plate is arranged between the impedance counting detection part and the rear plate, the rotating connecting plate is rotatably connected with the rear plate, the impedance sheath fluid pool is mounted on the rotating connecting plate, and the impedance sheath fluid control valve bank is mounted on the rotating connecting plate and/or the bottom plate.

9. The blood sample analyzer of claim 6, wherein: the blood routine testing assembly further includes an optical testing assembly comprising:

an optical detection reaction cell for preparing the blood sample into an optical detection blood sample, wherein the optical detection reaction cell is arranged between the first reaction cell and the rear plate;

the optical detection component is used for detecting white blood cell parameters and/or reticulocyte parameters of a blood sample, is arranged between the reaction tank for optical detection and the top plate, and is smaller than the distance from the rear plate to the front plate.

10. The blood sample analyzer of claim 9, wherein: the blood sample analyzer further comprises a sample preparation control valve group, wherein the sample preparation control valve group is connected between the optical detection reaction tank and the optical detection component through a pipeline, the sample preparation control valve group is arranged between the optical detection component and the bottom plate, and the sample preparation control valve group is arranged between the optical detection reaction tank and the rear plate; and/or the number of the groups of groups,

the reaction tank for optical detection comprises a second reaction tank and a third reaction tank, wherein the second reaction tank is used for preparing a blood sample into a blood sample for detecting leucocyte parameters, the third reaction tank is used for preparing the blood sample into a blood sample for detecting reticulocyte parameters, and the second reaction tank is arranged between the first reaction tank and the third reaction tank.

11. The blood sample analyzer of claim 9 or 10, wherein: the blood sample analyzer further comprises a dye liquor quantitative assembly, the dye liquor quantitative assembly comprises a dye liquor quantitative pump and a dye liquor quantitative sensor, the dye liquor quantitative assembly is arranged between the optical detection component and the front plate, and the distance from the dye liquor quantitative assembly to the top plate is smaller than the distance from the dye liquor quantitative assembly to the bottom plate.

12. The blood sample analyzer of claim 1, wherein: the blood sample analyzer further includes a power supply assembly, the power supply assembly including:

the mounting shell is mounted on the rear plate and is provided with an inner cavity, an air inlet communicated with the inner cavity and an air outlet communicated with the inner cavity;

the power supply is arranged in the inner cavity;

the first cooling fan is arranged at the air inlet or the air outlet.

13. The blood sample analyzer of claim 12, wherein: the top of the mounting shell is also provided with an outlet which is arranged towards the top plate and used for the wire to pass through; and/or the number of the groups of groups,

the power supply assembly further comprises a power switch and a power socket, and the power switch and the power socket are both installed on the installation shell.

14. The blood sample analyzer of claim 1, wherein: the blood sample analyzer further comprises a quantitative pump assembly, the quantitative pump assembly comprises a diluent quantitative pump and/or a hemolytic agent quantitative pump, the diluent quantitative pump is used for conveying diluent from the outside into the blood sample analyzer, the hemolytic agent quantitative pump is used for conveying hemolytic agent from the outside into the blood sample analyzer, the quantitative pump assembly is mounted on the frame and is adjacent to the rear plate, and the rear plate is provided with a second opening for facilitating disassembly and mounting of the quantitative pump assembly.

15. A blood sample analyzer according to any one of claims 1 to 3 or 6 to 14, wherein: the blood sample analyzer further comprises a circuit board assembly and an air pump, wherein the circuit board assembly and the air pump are both arranged on the top plate, the circuit board assembly and the air pump are both positioned above the top plate, and the blood routine detection assembly and the sampling assembly are both positioned below the top plate; and/or the number of the groups of groups,

the blood sample analyzer further comprises an air pressure detection circuit board, wherein the air pressure detection circuit board is located between the front plate and the shell, and the air pressure detection circuit board is close to the top end of the front plate.

16. The blood sample analyzer of any one of claims 1 to 4 or 6 to 14, wherein: the blood sample analyzer further comprises a dye liquor reagent bearing component, wherein the dye liquor reagent bearing component is used for bearing a dye liquor reagent container;

the housing includes a front shell, the front plate being located between the front shell and the rear plate;

the front shell comprises a front shell body and a door plate, a containing cavity and a third opening communicated with the containing cavity are formed between the front shell body and the front plate in a surrounding manner, and the door plate is rotationally connected or detachably connected with the front shell body and used for sealing or opening the third opening;

The dye liquor reagent bearing assembly can be slidably mounted in the accommodating cavity from the third opening.

17. The blood sample analyzer of claim 16, wherein: the dye liquor reagent bearing assembly comprises a bearing part, a first sliding part and a baffle plate, wherein the bearing part is used for bearing the dye liquor reagent container, the first sliding part is arranged at the bottom of the bearing part, and the baffle plate is arranged at one end of the first sliding part;

the dye liquor reagent fixing assembly comprises a connecting part, a second sliding part and two limiting buffer parts, wherein the first sliding part is in sliding connection with the second sliding part, the connecting part is arranged at one end of the second sliding part and is connected with the frame, and the two limiting buffer parts are respectively close to two ends of the second sliding part and are used for limiting the sliding stroke of the baffle.

18. The blood sample analyzer of any one of claims 1 to 4 or 6 to 14, wherein: the frame still includes first lateral part, second lateral part and well baffle, first lateral part with the second lateral part is followed respectively the opposite both sides of front bezel extend to the back plate, the well baffle respectively with the front bezel the back plate the bottom plate with the roof butt, just the well baffle with first lateral part interval sets up and with the second lateral part interval sets up, sampling assembly install in on the well baffle, blood routine detection subassembly locates between the well baffle with the second lateral part.

19. The blood sample analyzer of claim 18, wherein: the blood sample analyzer further comprises a liquid path inlet and outlet interface assembly, the liquid path interface assembly comprises a diluent inlet, a hemolytic agent inlet and a waste liquid outlet, the reagent interface assembly is mounted on the rear plate, the reagent interface assembly is located between the first side portion and the middle partition plate, and the distance from the reagent interface assembly to the bottom plate is smaller than the distance from the reagent interface assembly to the top plate.

20. The blood sample analyzer of claim 19, wherein: the blood sample analyzer further comprises a liquid detection assembly, wherein the liquid detection assembly comprises a diluent detection component and a hemolysis agent detection component, and the diluent detection component is communicated with the diluent access port and is used for judging whether diluent passes through the diluent access port or not; the hemolytic agent detection component is communicated with the hemolytic agent inlet and is used for judging whether the hemolytic agent passes through the hemolytic agent inlet or not;

the frame still includes first curb plate, first curb plate respectively with the front bezel the back plate the bottom plate with the roof butt, first curb plate with the middle septum exists the interval and with first side exists the interval, liquid detection subassembly install in on the first curb plate, liquid detection subassembly extremely the distance of back plate is less than to the distance of front bezel, just liquid detection subassembly extremely the distance of bottom plate is less than to the distance of roof.

21. The blood sample analyzer of claim 20, wherein: the blood sample analyzer further comprises a diluent reservoir mounted on the first side plate, and the distance from the diluent reservoir to the rear plate is smaller than the distance to the front plate, and the diluent reservoir is located between the top plate and the liquid detection assembly.

22. The blood sample analyzer of claim 21, wherein: the blood sample analyzer further comprises a waste liquid pool and a waste liquid pump assembly, wherein the waste liquid pool and the waste liquid pump assembly are mounted on the first side plate, the waste liquid pool is located between the waste liquid pump assembly and the bottom plate, the liquid detection assembly is located between the rear plate and the waste liquid pool, and the diluent liquid pool is located between the rear plate and the waste liquid pump assembly.

23. The blood sample analyzer of claim 22, wherein: the blood sample analyzer further comprises an air chamber, a control valve assembly and an isolation chamber, wherein the isolation chamber is used for isolating waste liquid and an air pressure sensor, the air chamber, the control valve assembly and the isolation chamber are all arranged on the first side plate, the air chamber, the control valve assembly and the isolation chamber are sequentially arranged along the direction of the rear plate towards the front plate, the air chamber is arranged between the diluent liquid storage tank and the top plate, and the control valve assembly is arranged between the waste liquid pump assembly and the top plate; and/or the number of the groups of groups,

The first side plate is also provided with a diluent quantitative liquid valve, a diluent quantitative gas valve, a hemolytic agent quantitative liquid valve, a hemolytic agent quantitative pump gas valve and a waste liquid valve component, wherein the diluent quantitative liquid valve, the diluent quantitative gas valve and the hemolytic agent quantitative pump gas valve are positioned between the diluent liquid storage pool and the liquid detection component, and the hemolytic agent quantitative liquid valve is positioned between the waste liquid pool and the liquid detection component; the waste valve assembly is located on a side of the waste reservoir facing the back plate.

24. The blood sample analyzer of claim 20, wherein: the blood sample analyzer further comprises a quantitative pump assembly, the quantitative pump assembly comprises a diluent quantitative pump and/or a hemolytic agent quantitative pump, the diluent quantitative pump is used for conveying diluent from outside into the blood sample analyzer, the hemolytic agent quantitative pump is used for conveying hemolytic agent from outside into the blood sample analyzer, the quantitative pump assembly is mounted on the first side plate, and the quantitative pump assembly is positioned between the liquid detection assembly and the bottom plate; and/or

The first side portion is a left side portion of the frame, and the second side portion is a right side portion of the frame.

25. A blood sample analyzer according to any one of claims 1 to 3 or 6 to 14, wherein: the sampling assembly comprises a sampling needle, a sample suction pipeline connected with the sampling needle and a motion driving device for driving the sampling needle to move;

the blood sample analyzer further comprises a blood sedimentation detection component, a part of the sample suction pipeline is used as a blood sedimentation detection pipe section, the blood sedimentation detection pipe section is used for providing a blood sedimentation detection place for a blood sample, and the blood sedimentation detection component is arranged beside the blood sedimentation detection pipe section and used for carrying out blood sedimentation detection on the blood sample in the blood sedimentation detection pipe section.

26. The blood sample analyzer of any one of claims 1 to 4 or 6 to 14, wherein: the blood sample analyzer further comprises:

a first syringe for driving the sampling assembly to aspirate a blood sample, for driving the sampling assembly to dispense the aspirated blood sample to the blood routine testing assembly, and for providing a driving force for sample pushing of the blood sample in the sample preparation line;

a second syringe for providing a driving force for a diluent into the blood routine testing assembly and for providing a driving force for sample preparation of a blood sample into the sample preparation line.

27. The blood sample analyzer of claim 26, wherein: the frame further includes first and second side portions extending from opposite sides of the front plate to the rear plate, respectively;

the first injector is arranged on the front plate, and the distance from the first injector to the first side part is smaller than the distance from the first injector to the second side part;

the second injector is disposed adjacent the first side and the second injector is less distant from the front plate than the rear plate.

28. The blood sample analyzer of claim 27, wherein: the blood sample analyzer further comprises:

the bus plate and the first injector are both arranged on the front plate, the distance from the bus plate to the first side part is smaller than the distance from the bus plate to the second side part, the inlet and outlet of the first injector are arranged upwards, and the bus plate is positioned between the first injector and the top plate;

the sampling control valve group is installed on the busbar, and the sampling control valve group is connected with the first injector through the busbar, so that the first injector is controlled to be switched on respectively the sampling assembly, the blood routine detection assembly and the diluent liquid storage tank.

29. The blood sample analyzer of claim 28, wherein: the sampling control valve group comprises a first control valve, a second control valve, a third control valve and a fourth control valve, wherein the first control valve is used for controlling the first injector to switch and conduct the sampling assembly and the blood routine detection assembly respectively so as to realize the switching of a sampling channel and a sample pushing channel, the second control valve is used for controlling the first injector to switch and conduct the sampling assembly and the diluent liquid storage tank respectively so as to realize the cleaning of the sampling assembly, the third control valve is used for controlling the first injector to switch and conduct the optical detection assembly and the impedance counting detection assembly respectively so as to realize the switching of an optical sample pushing channel and an impedance sample pushing channel, and the fourth control valve is used for controlling the diluent supply channel to pour diluent into the first injector; and/or the number of the groups of groups,

the blood sample analyzer further comprises a hydraulic detection component for detecting pressure parameters, wherein the hydraulic detection component is connected between the first injector and the confluence plate through a pipeline and is arranged on the front plate; the hydraulic pressure detection component is located between the first injector and the bus plate, or is located on one side of the bus plate facing the first side.

30. The blood sample analyzer of any one of claims 1 to 4 or 6 to 14, wherein: the blood sample analyzer completes one detection period of all detection items of one blood sample in the blood routine detection assembly, and the average gas consumption is less than or equal to 2.0L/min; and/or the number of the groups of groups,

the shell comprises a front shell, the front plate is located between the front shell and the rear plate, and the front shell is provided with a display screen.