CN116058831A - Method for nondestructive detection of blood glucose concentration by using microwave signals of fingertips - Google Patents
Method for nondestructive detection of blood glucose concentration by using microwave signals of fingertips Download PDFInfo
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- CN116058831A CN116058831A CN202111279219.6A CN202111279219A CN116058831A CN 116058831 A CN116058831 A CN 116058831A CN 202111279219 A CN202111279219 A CN 202111279219A CN 116058831 A CN116058831 A CN 116058831A
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- 239000008280 blood Substances 0.000 title claims abstract description 61
- 210000004369 blood Anatomy 0.000 title claims abstract description 61
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 41
- 239000008103 glucose Substances 0.000 title claims abstract description 41
- 238000000034 method Methods 0.000 title claims abstract description 11
- 238000001514 detection method Methods 0.000 title claims description 13
- 230000008859 change Effects 0.000 claims abstract description 25
- 238000002474 experimental method Methods 0.000 claims abstract description 7
- 230000005540 biological transmission Effects 0.000 claims abstract description 4
- 230000004044 response Effects 0.000 claims description 4
- 238000010586 diagram Methods 0.000 claims description 3
- 230000005284 excitation Effects 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 238000009659 non-destructive testing Methods 0.000 claims 1
- 230000036962 time dependent Effects 0.000 abstract description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 238000010241 blood sampling Methods 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 208000008960 Diabetic foot Diseases 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 238000007410 oral glucose tolerance test Methods 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/0507—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves using microwaves or terahertz waves
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- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Optics & Photonics (AREA)
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- Radiology & Medical Imaging (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The invention relates to a method for nondestructively detecting blood glucose concentration by using a microwave signal (including amplitude, phase and the like of a reflection coefficient and a transmission coefficient) of a fingertip. Firstly, fixing a pair of ultra-wideband antennas with the size of fingertips on the fingertips of a human body; connecting an antenna with a microwave emission source, calibrating and emitting an ultra-wideband signal; carrying out an oral glucose tolerance experiment on a subject, and recording a microwave signal detected in the experiment and a blood glucose value measured by a commercial blood glucose meter; reading the measured microwave signals of the blood sugar of the human body at different times; in the schemeS 21 For example, a frequency point is selected for observation after unwrappingS 21 The unwrapped phase of the parameter is in a time-dependent change relation, and is compared with a time-dependent change value of blood sugar measured by a commercial blood glucose meter, and the change trend of the unwrapped phase of the parameter is consistent with the time-dependent change value of blood sugar measured by the commercial blood glucose meter, so that the change of blood sugar of a human body can be detected by the change of a microwave signal.
Description
Technical Field
The invention belongs to the field of biomedical detection and ultra-wideband microwave nondestructive detection, and relates to a novel ultra-wideband microwave noninvasive blood glucose concentration detection device.
Background
Diabetes is a chronic disease that results in the pancreas no longer being able to produce insulin, or the body is not able to make good use of the insulin produced. Diabetes can cause a series of complications such as cardiovascular and cerebrovascular diseases, eye diseases, nephropathy, diabetic foot and the like. Therefore, diabetics need to constantly measure blood glucose levels to ensure timely medical attention, preventing exacerbations and complications. For normal persons, it is necessary to check the blood glucose level of the body regularly to prevent the risk of diabetes. The blood glucose level is clinically detected by drawing venous blood, the detection result of the method is the most standard, and in daily life, diabetics can also adopt a household blood glucose meter to take blood from fingertips for blood glucose detection. In order to monitor the blood sugar level of a diabetic patient in real time and reduce the pain and infection risk of blood sampling of the patient, a microwave noninvasive blood sugar detection method based on an ultra-wideband antenna can be adopted. The detection principle is that when the concentration of glucose in human blood changes, the dielectric properties of the blood also change, and when electromagnetic waves emitted by the ultra-wideband antenna penetrate through blood layers with different dielectric properties, the obtained receiving signals are different.
Disclosure of Invention
The present invention provides a microwave signal (including reflectance) for a fingertipS 11 And transmission coefficientS 21 Amplitude and phase, etc.) of the blood glucose concentration. The target tissue detected by the method is a finger tip part with dense blood vessels of a human body, a microwave emission source is used for providing excitation and recording detected microwave signals, and a commercial blood glucose meter with finger tip blood sampling is used for recording the blood glucose concentration value of the human body as a reference at the same time. The technical scheme of the invention is as follows:
a method for non-destructive detection of blood glucose levels in a human body using a microwave signal from a fingertip, comprising the steps of:
(1) Attaching a pair of ultra-wideband antennas with the size of a fingertip to the position aligned up and down of the fingertip of a human body, transmitting ultra-wideband signals by using one antenna, and receiving microwave signals penetrating through the fingertip part by using the other antenna;
(2) Carrying out an oral glucose tolerance experiment on a tested person, storing the measured microwave signals at certain intervals in the experiment process, and simultaneously carrying out invasive blood glucose detection on the tested person by using a commercial blood glucose meter and recording the blood glucose concentration value;
(3) Reading the collected microwave signals (including the amplitude, the phase and the like of the reflection coefficient and the transmission coefficient) of the blood sugar of the human body at different timesS 21 For example, a waveform diagram of the frequency domain response is drawn;
(4) Selecting a frequency point to giveS 21 Parameter unwrapping phase time-dependent graph and measuring blood glucose with domestic blood glucose meterAnd comparing the change values to obtain a rule with consistent change trend, and proving that the change of the microwave signal is caused by the change of the blood sugar concentration.
Drawings
FIG. 1 different timesS 21 Unwrapped phase of (2)
FIG. 2 shows different time periods in the 5.35-5.85GHz bandS 21 Unwrapped phase magnified image
FIG. 3.5 GHzS 21 Parameter unwrapping phase versus blood glucose concentration
Detailed Description
The invention is described below with reference to the drawings and examples.
(1) The change in blood glucose concentration in the human body causes a change in permittivity of the blood. Thus, the microwave signal may be used to characterize the blood glucose concentration of a human. Because blood vessels at the fingertip part of the human body are denser, a pair of ultra-wideband antennas are fixed at the fingertip part, and nondestructive detection of blood sugar of the human body can be realized by observing the change rule of microwave signals;
(2) Connecting an antenna with a microwave emission source and setting a working frequency band;
(3) In an oral glucose tolerance test, the measured microwave signals are stored at certain intervals, and meanwhile, the blood glucose concentration of a subject is measured and recorded by using a commercial blood glucose meter;
(4) The measured microwave signal is read and the waveform of its frequency domain response is plotted as shown in fig. 1. For ease of observation, the sugar tolerance experiments were selected at the beginning and at 15, 30 and 45 minutesS 21 Unwrapping phase for a frequency bandS 21 Amplifying the frequency domain response of the phase, as shown in fig. 2, selecting data in 5.35-5.85GHz for amplifying and observing;
(5) To search the relation between the microwave signal and the blood sugar concentration, a certain frequency point can be drawnS 21 The phase change curve of the parameter with time is compared with the change curve of blood glucose concentration measured by the household glucometer with time, for example, the data at one frequency point (5.5 GHz) is randomly selected in FIG. 3 for observation, and the change trend of the two is obtainedThe uniform rules prove that the change of the microwave signal is caused by the change of the blood sugar concentration, namely, the microwave signal can be transmitted through the microwaveS 21 The phase represents the change of blood sugar concentration of the human body.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the application. Thus, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
The foregoing is merely exemplary of the present application and is not intended to limit the present application. Various modifications and changes may be made to the present application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc. which are within the spirit and principles of the present application are intended to be included within the scope of the claims of the present application.
Claims (1)
1. The invention relates to a method for nondestructively detecting blood sugar concentration by using a microwave signal of a fingertip, wherein a target tissue detected by the method is a fingertip part of a human body, the microwave signal is provided by a microwave emission source to be excited and recorded, the commercial blood glucose meter for taking blood from the fingertip is used for recording the blood sugar concentration value of the human body as a reference at the same moment, and the feasibility of nondestructively detecting the blood sugar concentration by using the microwave signal of the fingertip is verified by comparing the trend of the blood sugar concentration measured by the commercial blood glucose meter with the trend of time, and the technical scheme of the invention is as follows:
a method for non-destructive testing of blood glucose concentration using a microwave signal from a fingertip, comprising the steps of:
(1) A pair of ultra-wideband antennas with the size of fingertips are fixed at the positions aligned up and down of the fingertips of a human body, and the two antennas are connected with a microwave emission source to provide excitation and record detected microwave signals;
(2) Carrying out an oral glucose tolerance experiment on a tested person, storing the measured microwave signals at certain intervals in the experiment process, and simultaneously carrying out invasive blood glucose detection on the tested person by using a commercial blood glucose meter and recording the blood glucose concentration value;
(3) Reading the collected microwave signals (including the amplitude, the phase and the like of the reflection coefficient and the transmission coefficient) of the blood sugar of the human body at different timesS 21 For example, a waveform diagram of the frequency domain response is drawn;
(4) Selecting a frequency point to giveS 21 And the parameter unwrapping phase change diagram along with time is compared with a blood glucose change value measured by a commercial blood glucose meter to obtain a rule with consistent change trend, and the change of the microwave signal is proved to be caused by the change of the blood glucose concentration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111279219.6A CN116058831A (en) | 2021-11-03 | 2021-11-03 | Method for nondestructive detection of blood glucose concentration by using microwave signals of fingertips |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111279219.6A CN116058831A (en) | 2021-11-03 | 2021-11-03 | Method for nondestructive detection of blood glucose concentration by using microwave signals of fingertips |
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| Publication Number | Publication Date |
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| CN116058831A true CN116058831A (en) | 2023-05-05 |
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| CN202111279219.6A Pending CN116058831A (en) | 2021-11-03 | 2021-11-03 | Method for nondestructive detection of blood glucose concentration by using microwave signals of fingertips |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180153520A1 (en) * | 2015-11-27 | 2018-06-07 | Rinat O. Esenaliev | Wearable, noninvasive glucose sensing methods and systems |
| CN109350076A (en) * | 2018-10-19 | 2019-02-19 | 天津大学 | Blood sugar concentration detection method based on ultra-wideband microwave S21 parameter |
| CN109846462A (en) * | 2019-04-03 | 2019-06-07 | 小甑科技（深圳）有限公司 | A kind of method and system measuring blood glucose |
| CN110916680A (en) * | 2019-11-29 | 2020-03-27 | 天津大学 | Non-invasive blood glucose concentration detection method based on S21 phase |
| WO2020183497A1 (en) * | 2019-03-13 | 2020-09-17 | Biofi Medical Healthcare India Private Limited | A non-invasive glucometer |
| CN111789599A (en) * | 2019-04-08 | 2020-10-20 | 吕川 | System and method for non-invasive detection of blood glucose |
-
2021
- 2021-11-03 CN CN202111279219.6A patent/CN116058831A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180153520A1 (en) * | 2015-11-27 | 2018-06-07 | Rinat O. Esenaliev | Wearable, noninvasive glucose sensing methods and systems |
| CN109350076A (en) * | 2018-10-19 | 2019-02-19 | 天津大学 | Blood sugar concentration detection method based on ultra-wideband microwave S21 parameter |
| WO2020183497A1 (en) * | 2019-03-13 | 2020-09-17 | Biofi Medical Healthcare India Private Limited | A non-invasive glucometer |
| CN109846462A (en) * | 2019-04-03 | 2019-06-07 | 小甑科技（深圳）有限公司 | A kind of method and system measuring blood glucose |
| CN111789599A (en) * | 2019-04-08 | 2020-10-20 | 吕川 | System and method for non-invasive detection of blood glucose |
| CN110916680A (en) * | 2019-11-29 | 2020-03-27 | 天津大学 | Non-invasive blood glucose concentration detection method based on S21 phase |
Non-Patent Citations (1)
| Title |
|---|
| CAMILLE J. CORDERO等: "《Quantifying Blood Glucose Level Using S11 Parameters》", PROC. OF THE 2017 IEEE REGION 10 CONFERENCE, 5 November 2017 (2017-11-05), pages 1481 - 1486 * |
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