CN1160539A

CN1160539A - Scar inhibitor and its compounding process

Info

Publication number: CN1160539A
Application number: CN 96116293
Authority: CN
Inventors: 陆达人
Original assignee: Individual
Current assignee: Individual
Priority date: 1996-03-28
Filing date: 1996-03-28
Publication date: 1997-10-01
Anticipated expiration: 2016-03-28
Also published as: CN1064237C

Abstract

The scar inhibitor contains polymethylvinyl siloxane, methyl silicone oil, silicone gel and solvent ether or dimethylbenzene. The said components in certain proportion are compounded into polymer aerosol for external use. When it is sprayed directly onto wound surface or scar surface, the scar inhibitor forms film after natural drying. Clinical application shows its obvious inhibition to scar tissue proliferation, its early use to wound surface can prevent scar from forming and its middle-stage use to proliferative scar can inhibit scar proliferation.

Description

A kind of scar inhibitor and compound method thereof

The present invention relates to a kind of external agent and preparing process that can suppress scar hyperplasia, specifically be used for the macromolecule dressing of this medical field.

Hypertrophic cicatrix often betides wound, burn wound healing position, cicatrix exceeds skin, out-of-shape, flushing hyperemia, strong but pliable in texture, often accompany sufferings, the existing hypertrophy of preventing and treating cicatrix with clinically processing elastomeric material pressure dressing commonly used in the technology, because it is cicatrix often is the shape that is uneven,, fixing in the then difficult operation of joint as affected part with the elastomeric material loose contact; The cycle for the treatment of in this way not only is long, and phenomenon is repeatedly arranged, and effect is not really desirable, and incompatibility larger area cicatrix by retrieval, has applied for that disclosed patent has " scar-removing beauty cream and method for making thereof ", application number 91105837.1, CN:1058529 especially; " a kind of scar-leveling cream and production technology thereof " application number 93102881.8, CN:1091977 contains the antibiotic medicine in these frosts, and loses the curative effect report to the hypertrophic cicatrix in mid-term.

The object of the present invention is to provide a kind of to early, mid-term cicatrix all effective in cure, scar inhibitor easy to use and compound method thereof.

Technical scheme of the present invention is achieved in that it is the scar inhibitor that can spray aerosol in a kind of container that is contained in sealing by valve, and it is characterized in that: described scar inhibitor component and proportioning are as follows:

The rare based polysiloxane 1-15% of methyl second

Methyl-silicone oil 2-30%

Silicone gel 5-30%

Ethers or dimethylbenzene surplus

The compound method of scar inhibitor of the present invention is characterized in that:

A. the rare based polysiloxane of methyl second is dissolved in ethers or the xylene solvent, stirs and tremble the concentration that makes the rare based polysiloxane of methyl second and be controlled at and make liquid (1) between the 5-35%;

B. the 10-60% that gets the liquid of making (1) mixes with methyl-silicone oil 40-90% and fully stirs and make another kind of liquid (2);

C. 1: 1 liquid (1) is poured in the container with another liquid (2), the silicone gel that adds 8-40%, add solvent ethers or dimethylbenzene again, stir, the concentration dilution that makes the rare based polysiloxane of methyl second is 1-15%, be filled into container again, charge into propellant and after packing, promptly make scar inhibitor, push the scar inhibitor that valve can spray mist facing to cicatrix during use.

This scar inhibitor can directly be sprayed at healing wound surface or cicatrix surface, the self-desiccation film forming, no matter affected part is in what position and cicatrix area size of health, use all very convenient, through the Ruijin Hospital Attached to Shanghai Medical Univ No.2 clinic trial scar tissue hypertrophy is had obvious inhibitory action, the wound surface that is applied in early days to heal can prevent the formation of cicatrix, the hypertrophic cicatrix in being applied to mid-term form, the continuation hypertrophy that can obviously suppress cicatrix, and more early result of use is good more after the cicatrix healing.

Now use the 33 routine cicatrix patients' that this scar inhibitor treats curative effect statistics as follows in Rui Jin hospital:

Symptom	Case load	Significant figure	Effective percentage
Symptom	Case load	Significant figure	Effective percentage	The flat person of scar hyperplasia thickness 0.5-1.0cm＜0.5cm	????8 ????16 ????9	????7 ????16 ????9	????97.0％
Itch	????30	????30	????100％		????8 ????16 ????9	????7 ????16 ????9	????97.0％
Itch	????30	????30	????100％	Bitterly	????21	????21	????100％
Congested	???33	????30	????90.9％	Bitterly	????21	????21	????100％

More than the treatment in the statistics effectively is: cicatrix hyperemia and sufferings symptom obviously alleviate, and hypertrophy is softened, highly reduced or no longer continue to the cicatrix quality.

The invention will be further described below in conjunction with embodiment.

The present invention in order to quicken its dissolving, adds the catalyst platinic acid in an embodiment on the basis based on such scheme, emulsifying agent department big belly 80 and cross-linking agent methyl triacetyl silane, and concrete set of dispense when compound method is as follows:

Embodiment 1

The rare based polysiloxane 2-10% of methyl second

Methyl-silicone oil 3-6%

Methyl Hydrogen Polysiloxane Fluid 3-6%

Silicone gel 6-20%

Big belly 80 0.2-1% of department

Methyl acetyl silane 0.05-1%

Platinic acid 0.001-0.01%

The ethers surplus

Compound method is:

A. the rare based polysiloxane of methyl second is dissolved in the ether solvent, the platinic acid catalyst that adds trace stirs, and the concentration of the rare radical siloxane of methyl second is controlled between the 8-25%, makes liquid (1);

B. earlier methyl-silicone oil and Methyl Hydrogen Polysiloxane Fluid are become mixing silicone oil with 1: 1 mixed, get the 15-50% that makes liquid (1) and mix silicone oil 50-85% and mix, the cross-linking agent methyl triacetyl alkane that adds 0.1-2% more fully stirs makes another kind of liquid (2);

C. 1: 1 liquid (1) is poured in the container with another liquid (2), add the silicone gel of 10-30% and the emulsifying agent department big belly 80 of 0.3-1.5%, adding the solvent ethers again stirs, the concentration dilution that makes the rare based polysiloxane of methyl second is 2-10%, be filled into aluminium pot again, charge into propellant F12, after packing, promptly make, at the ethers described in the process for preparation is petroleum ether, dimethyl ether, ether class, all will use with a kind of solvent in whole process for preparation.

Embodiment 2

The rare based polysiloxane 2% of methyl second

Methyl-silicone oil 6%

Silicone gel 6%

The petroleum ether surplus

Embodiment 3

The rare based polysiloxane 5.5% of methyl second

Methyl-silicone oil 7.5%

Silicone gel 1.5%

The dimethylbenzene surplus

Claims

1. a scar inhibitor is characterized in that, its component and proportioning are as follows:

The rare based polysiloxane 1-15% of methyl second

Methyl-silicone oil 2-30%

Silicone gel 5-30%

Ethers or dimethylbenzene surplus

2. by the described a kind of scar inhibitor of claim 1, it is characterized in that: ethers is petroleum ether, dimethyl ether, ether class.

3. a scar inhibitor is characterized in that, its component and proportioning are as follows:

The rare based polysiloxane 2-13% of methyl second

Methyl-silicone oil 3-6%

Methyl Hydrogen Polysiloxane Fluid 3-6%

Silicone gel 6-20%

Big belly 80 0.2-1% of department

Methyl triacetyl silane 0.05-1%

Platinic acid 0.001-0.01%

The ethers surplus

4. by the compound method of the described scar inhibitor of claim 1, it is characterized in that:

A. the rare based polysiloxane of methyl second is dissolved in ethers or the xylene solvent, stirs the concentration of the rare based polysiloxane of methyl second is controlled between the 5-35%, make liquid (1);

B. getting the 10-60% that makes liquid (1) mixes with methyl-silicone oil 40-90% and fully stirs and make another liquid (2);

C. 1: 1 liquid (1) is poured in the container with another liquid (2), added the silicone gel of 8-40%, add solvent ethers or dimethylbenzene again, stir, the concentration dilution that makes the rare based polysiloxane of methyl second is 1-15%.

5. by the compound method of the described scar inhibitor of claim 4, it is characterized in that: in whole process for preparation, all will use with a kind of solvent.

6. by the compound method of the described scar inhibitor of claim 3, it is characterized in that:

A. the rare based polysiloxane of methyl second is molten in ether solvent, the platinic acid catalyst that adds trace stirs, and the concentration of the rare radical siloxane of methyl second is controlled between the 8-25%, makes liquid (1);

B. earlier methyl-silicone oil and Methyl Hydrogen Polysiloxane Fluid are become mixing silicone oil with 1: 1 mixed, get the 15-50% that makes liquid (1) and mix silicone oil 50-85% and mix, the cross-linking agent methyl triacetyl silane that adds 0.1-2% more fully stirs makes another liquid (2);

C. 1: 1 liquid (1) is poured in the container with another liquid (2), added the silicone gel of 10-30% and the emulsifying agent department big belly 80 of 0.3-1.5%, add the solvent ethers again and stir, the concentration dilution that makes the rare based polysiloxane of methyl second is 2-13%