CN1116095A - Mucilage for curing burn - Google Patents

Abstract

The invented recipe mainly consists of 0.5-5% of sodium carboxy methylc ellulose, 1-5% of gelatin, 5-25% of glycerin, 5-25% of glucose and 50-85% of distilled water. The recipe can also be added the 0.01%-0.02% of dexamethasone, 0.25-3% of chloromycetin, and 0.02-0.1% of nipagin ethyle ster. Said mucilage can form a protective film on the surface of wound and possesses of the actions of nourishing the surface of wound, dephlogisticating and antiallergy.

Description

A kind of mucilage that is used for the treatment of burn

The invention discloses a kind of mucilage, it can be used for treating the skin injury such as damage, burn, ulcer of epidermis or whole skin surface.

Treatment for burn, particularly than the treatment of large-area burns, be difficult to reach gratifying effect, what difficulty was avoided is the formation and the contracture thereof of burn back cicatrix, and consequent muscle adhesion, infection, pain even serious burn can also influence the whole body organ, and final threat to life.Burn injury also often can cause the septic poisoning.

So to the treatment of burn, main task is to eliminate the body gram, prevents to shorten at least septic then and poisons the phase, be to change on tissue of burn and the window dressing and defective scar on the function at last.

After eliminating shock; remove downright bad tissue; the topical therapeutic that can begin to burn then; because the protection physiological action of skin is lost; so the purpose of topical therapeutic is to protect burn injury; prevent physical injury, dehydration, replenish body fluid and electrolytical loss and control infection and promote wound healing.

According to hitherto known method, can use and promote epitheliogenic oil preparation, sterilization varnish and paste to carry out above-mentioned treatment, can use above-mentioned preparation by traditional approach, apply the surface of damaged epidermis in other words with its, make open treatment or enclosed type treatment then, perhaps it is applied on the textile material as carrier and makes plaster.But, when using above-mentioned preparation or plaster, secretions takes place easily build up phenomenon, the result makes burn surfaces become very thick thick.Hydrous ointment and the Emulsion that is used for the treatment of wound as usual can produce dehydration, thereby make the wound desiccation on wound, form undesirable scar, and the healing cycle of wound prolongs also.

Have antibiotic and the preparation chemotherapy effect in order to develop, people have done many effort.

According to a kind of substrate for the treatment of burn of introducing in the European patent 40861, its prescription contains glycerol, polyvinyl alcohol, polyvinylpyrrolidone and water.This burn substrate is a kind of polymer thin slice of soft and transparent, can directly apply to all wound surface, can gently invest epidermis.

In British patent 2048070A, introduced to use sugar or use sugar and added that povidon iodine makes Ointment in Treatment open wound and burn wound.According to this article introduction, this therapeutic agent has and promotes the granulation growth, purifies wound surface, effect such as antibacterial.

In United States Patent (USP) 4604384, described a kind of medicine mucilage, wherein contained propylene glycol 20～30%, hydroxyethyl-cellulose 1～4%, the water of sodium chloride 0～2% and surplus.Mucilage can also add antibiotic: as gentamycin 0.1～0.4%, and glucocorticoid 0.5～1.0%, disinfectant: as hibitane 0.2～1.0%.This article is introduced this mucilage and be can be used for burn, wound; when using; this mucilage can form softish no infiltrative protective layer; this protective layer becomes effective anti-pollution barrier and mechanical barrier, can form firm adhesive linkage with the wound fluid reaction again, and is easy to soak or treat to come off voluntarily behind the epithelium regeneration; prevent the wound surface incrustation; make the hair normal growth, simultaneously also suppressed scar hyperplasia, keep the muscle normal activity after making skin healing.

The object of the present invention is to provide a kind of mucilage that is used for the treatment of burn, it can form layer protecting film at wound surface, makes wound surface lubricated, and keeps certain humidity, and also nutritious wound surface, antibiotic, antianaphylactic effect promote that wound surface heals early.Epithelial growth healing back cicatrix is few or do not have the cicatrix hyperplasia, and color and sensation kept normally after general skin was healed.

The present invention adopts water-soluble high-molecular substance, as sodium carboxymethyl cellulose, methylcellulose or starch etc., sodium carboxymethyl cellulose preferably adds gelatin-as thickening agent, glycerol-conduct lubricant of preserving moisture, glucose-form mucilage basis as nutritional labeling and water.This mucilage can add one or more burn treating agent: the antibiotics composition, as chloromycetin or neomycin etc., antiinflammatory antiallergic constituents, glucocorticoid, as dexamethasone, can ground pine or hydrocortisone etc., can add an amount of antiseptic in addition, as ethyl hydroxybenzoate or benzoic acids.

The mucilage that is used for the treatment of burn of the present invention, contain following constituent (w/v percentage ratio):

Sodium carboxymethyl cellulose 0.5～5%;

Gelatin 1～5%;

Glycerol 5～25%;

Glucose 5～25%;

Distilled water 50～85%.

Sodium carboxymethyl cellulose wherein can replace with the methylcellulose or the starch 5～20% (w/v) of equivalent.

Preferably add following ingredients (w/v percentage ratio) in the prescription:

Dexamethasone 0.01～0.02%;

Chloromycetin 0.25～3%;

Ethyl hydroxybenzoate 0.02～0.1%.

Dexamethasone wherein can replace with cortisone 0.25～1% or hydrocortisone 0.25～1%.Chloromycetin can replace with equivalent polygynax or erythromycin.

Mucilage using method of the present invention: earlier burn wound is carried out debridement treatment with normal saline, again mucilage is applied to wound surface, generally adopt exposure method, also the block therapy of available wrapping.Exposure method can form layer protecting film at wound surface, and the thickness of protecting film and intensity can be controlled according to application times, and general coating gets final product for 1～2 time.Occlusive dressing was changed dressings once in 3～4 days, and is bonding very tight as medicine and wound surface, do not have secretions again, then need not change dressings.

Use the mucilage of the formula proportion preparation of the embodiment of the invention 1, contrast when treatment is burnt with using the silver sulfadiazine cream, mucilage of the present invention can make patient's wound secretion reduce, dressing change frequency is few, has reduced operability, the also corresponding shortening of wound healing time, and medicine lower cost, use patient comfort, painful less, so welcome by doctors and patients.

Use the mucilage of the formula proportion preparation of the embodiment of the invention 1, treat 200 many cases patients clinically, just can make wound healing in general 4～7 days for the minor burn below shallow II °, for dark II ° of burn or burn patients, generally can make wound healing about 20 days, the treatment cure rate reaches more than 95%.

Press the mucilage of the formula proportion preparation of the embodiment of the invention 1, do acute toxicity test, give the dose of mice lavage 0.4ml/20g, be equivalent to the former dose of 1000ml/50kg, no acute toxic reaction.The proof avirulence has no side effect.

Introduce embodiment below:

Embodiment 1

Prescription is formed:

Sodium carboxymethyl cellulose 3g, glucose 10g, gelatin 2g, glycerol 10ml, ethyl hydroxybenzoate 0.05g, dexamethasone 0.015g, chloromycetin 1g, distilled water 80ml.

Preparation method:

At first the gelatin fine powder is used distilled water immersion one hour, make it to add sodium carboxymethyl cellulose after the abundant imbibition, glucose and dexamethasone are heated to 40～50 ℃, are stirred to whole dissolvings, get rubber cement liquid; Glycerol is heated to 80 ℃ again, adds chloromycetin and ethyl hydroxybenzoate, stir and treat to dissolve fully back and above-mentioned rubber cement liquid merging, stir evenly, promptly get the mucilage finished product.

Embodiment 2

Prescription is formed:

Sodium carboxymethyl cellulose 2g, glucose 10g, gelatin 2g, glycerol 10ml, ethyl hydroxybenzoate 0.05g, hydrocortisone 0.5g, chloromycetin 1g, distilled water 80ml.

Preparation method:

At first the gelatin fine powder is used distilled water immersion one hour, make it to add sodium carboxymethyl cellulose and glucose after the abundant imbibition, be heated to 40～50 ℃, be stirred to whole dissolvings, get rubber cement liquid; Glycerol is heated to 80 ℃ again, adds chloromycetin, ethyl hydroxybenzoate, stir and treat to dissolve fully, get glycerin liquid; Other gets hydrocortisone, puts in the mortar, and slowly gradation adds glycerin liquid, grinds to form fine and smooth pasty state, adds remaining glycerin liquid and above-mentioned rubber cement liquid again, stirs evenly, and promptly gets the mucilage finished product.

Embodiment 3

Prescription is formed:

Starch 10g, glucose 10g, glycerol 10ml, gelatin 2g, ethyl hydroxybenzoate 0.05g, cortisone 0.5g, polygynax 1g, distilled water 80ml.

Preparation method:

At first get starch, glucose is mixed well with the 10ml distilled water, adds the 50ml distilled water, is heated to and boils, and stirs evenly, and puts cold starch fluid; Again with the gelatin fine powder with 20ml distilled water immersion one hour, make it abundant imbibition after, be heated to 40～50 ℃, be stirred to whole dissolvings, merge with above-mentioned starch fluid again, add polygynax then, stir evenly rubber cement liquid; Glycerol is heated to 80 ℃ in addition, adds ethyl hydroxybenzoate, stir and treat to dissolve fully, get cortisone again, put in the mortar, slowly gradation adds glycerin liquid, grinds to form fine and smooth pasty state, adds remaining glycerin liquid and above-mentioned rubber cement liquid again, stirs evenly, and promptly gets the mucilage finished product.

Claims (4)

1, a kind of mucilage that is used for the treatment of burn is characterized in that containing following constituent (w/v percentage ratio):

Sodium carboxymethyl cellulose 0.5～5%;

Gelatin 1～5%;

Glycerol 5～25%;

Glucose 5～25%;

Distilled water 50～85%.

2, mucilage according to claim 1 is characterized in that the methylcellulose or the starch 5～20% (w/v) of sodium carboxymethyl cellulose usefulness equivalent wherein replaces.

3, mucilage according to claim 1 and 2 is characterized in that also adding in the prescription following ingredients (w/v percentage ratio):

Dexamethasone 0.01～0.02%;

Chloromycetin 0.25～3%;

Ethyl hydroxybenzoate 0.02～0.1%.

4, mucilage according to claim 3 is characterized in that dexamethasone wherein replaces with cortisone 0.25～1% (w/v) or hydrocortisone 0.25～1% (w/v).