CN116047091A

CN116047091A - Sample image scanning equipment, sample detection system and liquid-based sample detection system

Info

Publication number: CN116047091A
Application number: CN202211581704.3A
Authority: CN
Inventors: 林冲; 卢江涛; 闫红力
Original assignee: Shenzhen Reetoo Biotechnology Co Ltd
Current assignee: Shenzhen Reetoo Biotechnology Co Ltd
Priority date: 2022-12-09
Filing date: 2022-12-09
Publication date: 2023-05-02

Abstract

The application discloses sample image scanning equipment, sample detecting system and liquid base sample detecting system, including transfer device, dispatch device, scanning device and slide uninstallation device, transfer device includes first track and transfer mechanism, be equipped with in the transposition and retrieve the position on the first track, transfer mechanism is used for along first track removal, with the first slide basket that loads the slide to in the transposition, and with empty first slide basket from in the transposition transfer to retrieve the position, dispatch device is used for shifting the slide that is arranged in the transposition to the scanning position, scanning device is used for scanning the slide that is arranged in the scanning position, slide uninstallation device is used for holding the slide that accomplishes the scanning, dispatch device still is used for shifting the slide that accomplishes the scanning to slide uninstallation device, the slide that accomplishes the scanning is deposited through slide uninstallation device, save the latency of slide basket and can avoid the slide basket to be polluted by mirror oil, make things convenient for the reuse of slide basket, promote work efficiency.

Description

Sample image scanning equipment, sample detection system and liquid-based sample detection system

Technical Field

The application relates to the technical field of medical equipment, in particular to sample image scanning equipment, a sample detection system and a liquid-based sample detection system.

Background

The sample image scanning equipment is equipment for carrying out automatic microscopic examination on a slide to be detected after the slide is made, and is used for assisting in diagnosing diseases by shooting a sample image on the slide through a microscope and obtaining a detection result through system analysis and judgment. Microscopy is short for microscopic examination, which is to take a sample of a specimen to be examined, slide the slide of which is made into slices, and observe, analyze and judge the sample under a microscope. Wherein human excreta, secretion, abscisic cells or tissues, animal tissues, even plant cells, etc. can be used as the object of microscopic examination, and the common scope is to assist in diagnosing diseases.

At present, in the operation process of a sample image scanning device, a slide to be detected is usually loaded through a slide basket and transported to a corresponding position of the sample image scanning device for scanning through a transport device, and the slide needs to be placed back into the slide basket for original sample feeding for slide unloading after the scanning is completed, so that the slide basket has long waiting time and the working efficiency of the sample image scanning device is affected.

Disclosure of Invention

In view of this, the present application proposes a sample image scanning apparatus, a sample detection system, and a liquid-based sample detection system.

A first aspect of the present application proposes a sample image scanning device comprising:

the transfer device comprises a first track and a transfer mechanism, wherein a middle position and a recovery position are arranged on the first track, and the transfer mechanism is used for moving along the first track so as to transfer a first slide basket loaded with slides to the middle position and transfer the empty first slide basket from the middle position to the recovery position;

a scheduling device for transferring the slide positioned in the transfer position to a scanning position;

the scanning device is used for scanning the slide positioned at the scanning position;

and the slide unloading device is used for accommodating the scanned slide, and the scheduling device is also used for transferring the scanned slide to the slide unloading device.

A second aspect of the present application proposes a sample detection system, including a slide making apparatus, a first detection apparatus, a control device, a display device, and the above-mentioned sample image scanning apparatus, where the first detection apparatus, the slide making apparatus, and the sample image scanning apparatus are electrically connected to the control device, the first detection apparatus is configured to detect the sample and output a first detection result, the slide making apparatus is configured to prepare a sample slide, the sample image scanning apparatus is configured to receive and scan the sample slide prepared by the slide making apparatus, when the first detection result is abnormal, the control device controls the slide making apparatus to prepare a sample slide and controls the sample slide to be transported to the sample image scanning apparatus, the image scanning apparatus receives and scans the sample slide and outputs the scanning result, and the display device displays the first detection result and the scanning result; wherein the sample is any one of a blood sample and a gynecological sample.

A third aspect of the present application proposes a liquid-based sample detection system, including a slide-making apparatus, a control device, a display device, and the above-mentioned sample image scanning apparatus, slide-making apparatus and sample image scanning apparatus with the control device is electrically connected, the slide-making apparatus is used for preparing liquid-based sample slide, sample image scanning apparatus is used for receiving and scanning the liquid-based sample slide that the slide-making apparatus prepared, the control device controls slide-making apparatus prepares liquid-based sample slide and control will liquid-based sample slide is carried to sample image scanning apparatus, sample image scanning apparatus receives and scans liquid-based sample slide and output the scanning result, display device shows the scanning result.

From foretell technical scheme can see, the sample image scanning equipment of this application is moved at first track through transfer device to with the first slide basket that is loaded with the slide is transported to well transposition, and will empty first slide basket is transported to retrieving the position, compact structure, rational utilization space, the slide can be shifted out with empty first slide basket after all taking out by dispatch device, need not to wait for whole slide scanning to accomplish in situ, the slide of completion scanning is deposited through slide uninstallation device, save the latency of slide basket and can avoid the slide basket to be polluted by mirror oil, make things convenient for the reuse of slide basket, promote work efficiency.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present application, and other drawings may be obtained by those skilled in the art without inventive effort.

Fig. 1 is a schematic diagram of a hidden portion structure of a first embodiment of a sample image scanning apparatus according to the present application.

Fig. 2 is a schematic diagram of a hidden portion structure of a sample image scanning apparatus according to a second embodiment of the present application.

Fig. 3 is an enlarged partial schematic view at a in fig. 2.

Fig. 4 is a schematic structural diagram of a second embodiment of the sample image scanning apparatus proposed in the present application.

Fig. 5 is a partially enlarged schematic view at B in fig. 4.

Fig. 6 is a schematic view of a sample image scanning apparatus according to the present application after opening an inspection area.

Fig. 7 is a schematic structural diagram of a first embodiment of a sample image scanning apparatus proposed in the present application.

Fig. 8 is a schematic view of a slide recognizing apparatus and a rotating mechanism according to the present application.

Fig. 9 is a schematic structural diagram of a transfer device, a sample feeding device and a sample discharging device according to the present application.

Fig. 10 is an enlarged partial schematic view of the transfer device proposed in the present application.

Fig. 11 is a schematic structural view of a slide unloading device proposed in the present application.

Fig. 12 is a schematic structural diagram of a scheduling apparatus proposed in the present application.

Fig. 13 is a schematic structural diagram of a cache module proposed in the present application.

Fig. 14 is a schematic view illustrating the docking of the transport assembly and the scanning platform according to the present application.

In the figure: 100. a sample image scanning device; 10. a transfer device; 11. a first track; 111. indexing; 112. recovering the position; 113. taking and placing; 12. a transfer mechanism; 121. a pushing structure; 1211. a first pushing section; 1212. a second pushing part; 122. a fourth driving module; 123. a receiving member; 1231. a first accommodating groove; 1232. a second accommodating groove; 20. a scheduling device; 21. a first transfer mechanism; 211. an X-axis driving module; 212. a Y-axis driving module; 213. a Z-axis driving module; 214. mechanical clamping jaws; 22. a second transfer mechanism; 22a, cache bits; 221. a cache component; 2211. a first driving module; 2212. a buffer seat; 222. a transport assembly; 2221. a second driving module; 2222. a transport structure; 30. a scanning device; 31. scanning the bits; 31a, a first scan bit; 31b, a second scan bit; 32. a scanning mechanism; 33. a scanning platform; 40. a slide unloading device; 41. a slide receiving bin; 411. a slot; 50. slide recognition means; 51. a camera; 52. a light barrier; 60. a rotation mechanism; 61. a rotating seat; 62. a rotating electric machine; 70. a controller; 80. a sample introduction device; 81. a second track; 82. a first pushing mechanism; 90. a sample discharging device; 91. a third track; 92. a second pushing mechanism; 110. a housing; 110a, a first space; 110b, a second space; 110c, a third space; 110d, a fourth space; 110e, fifth space; 110f, sixth space; 1101. a top plate; 1102. a bottom plate; 1103. a front plate; 1103a, a first front plate; 1103b, a second front plate; 1104. a rear plate; 1105. a first side plate; 1106. a second side plate; 120. a first separator; 130. a second separator; 140. mirror oil receiving means; 150. an access cover; 160. an overhaul area; 161. an access opening; 170. an emergency treatment device; 171. a fourth track; 172. a transfer mechanism; 180. a review device; 181. a bearing seat; 182. a sixth driving module; 200. a first slide basket; a second slide basket 300.

Detailed Description

The following description of the embodiments of the present application will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are some, but not all, of the embodiments of the present application. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the present disclosure.

It is also to be understood that the terminology used in the description of the present application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used in this specification and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.

It should be further understood that the term "and/or" as used in this specification and the appended claims refers to any and all possible combinations of one or more of the associated listed items, and includes such combinations.

From this, this application embodiment provides a sample image scanning equipment, and the slide of accomplishing the scanning is deposited through slide uninstallation device, saves the latency of slide basket and can avoid the slide basket to be polluted by mirror oil moreover, makes things convenient for the reuse of slide basket, promotes work efficiency.

Referring to fig. 1-2, a sample image scanning apparatus 100 according to an embodiment of the present application includes a transferring device 10, a dispatching device 20, a scanning device 30, and a slide unloading device 40, where the scanning device 30 is a microscope assembly capable of performing a microscopic examination on a slide, the transferring device 10 includes a first rail 11 and a transferring mechanism 12, the first rail 11 is provided with a middle position 111 and a recovery position 112, the transferring mechanism 12 is configured to move along the first rail 11 to transfer a first slide basket 200 loaded with a slide to the middle position 111, and transfer an empty first slide basket 200 from the middle position 111 to the recovery position 112, the dispatching device 20 is configured to transfer the slide located at the middle position 111 to the scanning position 31, the scanning device 30 is configured to scan the slide located at the scanning position 31, the slide unloading device 40 is configured to receive the scanned slide, and the dispatching device 20 is further configured to transfer the scanned slide to the slide unloading device 40.

The sample image scanning equipment 100 of this embodiment removes at first track 11 through transfer device 10 to transfer the first slide basket 200 that will load the slide to transfer position 111, and transfer the first slide basket 200 of empty to retrieving position 112, compact structure, rational utilization space, the slide can be shifted out with the first slide basket 200 of empty after all taking out by dispatch device 20, need not to wait for whole slide scanning to accomplish in the normal position, the slide of completion scanning is deposited through slide uninstallation device 40, save the latency of slide basket and can avoid the slide basket to be polluted by the mirror oil, make things convenient for the reuse of slide basket, promote work efficiency.

In some embodiments, as shown in fig. 1, 12-14, the scheduler 20 includes a first transfer mechanism 21 and a second transfer mechanism 22, the second transfer mechanism 22 having a buffer location 22a, the first transfer mechanism 21 for transferring slides at the intermediate index 111 to the buffer location 22a, the second transfer mechanism 22 for transferring slides to be scanned at the buffer location 22a to the scan location 31, and transferring scanned slides to the buffer location 22a, the first transfer mechanism 21 further for transferring scanned slides from the buffer location 22a to the slide unloader 40; wherein the projection of the moving path of the first transfer mechanism 21 in the vertical direction covers the region where the index 111, the buffer position 22a and the slide unloading device 40 are located, so that one first transfer mechanism 21 can transfer slides between the index 111, the buffer position 22a and the slide unloading device 40. In the present embodiment, by arranging the above-described manner such that one first transfer mechanism 21 is provided, transfer of the slide from the intermediate transfer position 111 to the buffer position 22a and transfer of the scanned slide from the buffer position 22a to the slide unloading device 40 can be achieved.

In some embodiments, the index 111, slide unloading device 40, and buffer 22a are arranged below the movement path of the first transfer mechanism 21 in a horizontal direction to shorten the movement path of the first transfer mechanism, facilitating machine miniaturization.

In some embodiments, as shown in fig. 2 and 12, the first transfer mechanism 21 includes an X-axis driving module 211, a Y-axis driving module 212, a Z-axis driving module 213, and a mechanical gripper 214, the X-axis driving module 211 is used to drive the mechanical gripper 214 to move in an X-axis direction, the X-axis direction is a left-right direction of the sample image scanning apparatus 100, the Z-axis driving module 213 is used to drive the mechanical gripper 214 to move in a Z-axis direction, the Z-axis direction is a height direction of the sample image scanning apparatus 100, the Y-axis driving module 212 is used to drive the mechanical gripper 214 to move in a Y-axis direction, the Y-axis direction is a front-back direction of the sample image scanning apparatus 100, and the mechanical gripper 214 is used to grip or release a slide to transfer the slide. In this embodiment, by the arrangement of the X-axis driving module 211, the Y-axis driving module 212 and the Z-axis driving module 213, the mechanical clamping jaw 214 can be driven to move in three-dimensional space, so as to transfer between a plurality of positions on a slide.

In some embodiments, the index 111, the buffer station 22a, and the slide unloading device 40 are all positioned below the path of movement of the mechanical clamping jaw 214 to facilitate transfer of slides between the index 111, the buffer station 22a, and the slide unloading device 40.

Illustratively, the X-axis driving module 211, the Y-axis driving module 212 and the Z-axis driving module 213 may adopt a driving mode of driving members combined with a transmission structure, the driving members of the Y-axis driving module 212 are connected to the X-axis driving module 211 through the transmission structure, the driving members of the X-axis driving module 211 are connected to the Z-axis driving module 213 through the transmission structure, and the driving members of the Z-axis driving module 213 are connected to the mechanical clamping jaw 214 through the transmission structure, so as to realize the movement of the mechanical clamping jaw 214 in the X-axis, the Y-axis and the Z-axis directions. The driving members of the X-axis driving module 211, the Y-axis driving module 212 and the Z-axis driving module 213 may be driving motors or other devices capable of providing driving force, and the transmission structure may be any one of a belt transmission mechanism, a chain transmission mechanism, a rack and pinion transmission mechanism or a screw transmission mechanism, so as to drive the mechanical clamping jaw 214 to move.

In some embodiments, as shown in fig. 12-14, the slide has a vertical state when sampling and a horizontal state when scanning, the first transfer mechanism 21 is used for transferring the slide in the vertical state, the second transfer mechanism 22 includes a buffer assembly 221 and a conveying assembly 222, the buffer assembly 221 includes a first driving module 2211 and a buffer seat 2212 for carrying the slide, the buffer seat 22a is provided on the buffer seat 2212, the first driving module 2211 is used for driving the buffer seat 2212 to rotate, so that the slide on the buffer seat 22a is switched between the vertical state and the horizontal state, the conveying assembly 222 includes a second driving module 2221 and a conveying structure 2222 for conveying the slide, and the second driving module 2221 is used for driving the conveying structure 2222 to move so as to transfer the slide in the horizontal state between the buffer seat 22a and the scanning position 31. In this embodiment, the first transfer mechanism 21 is used for transferring a slide in a vertical state from the middle position 111 to the buffer position 22a, the second transfer mechanism 22 drives the buffer seat 2212 to rotate through the first driving module 2211, so that the slide on the buffer position 22a is converted into a horizontal state from a vertical state, then the second driving module 2221 drives the conveying structure 2222 to move, so that the slide in the horizontal state to be scanned is transferred to the scanning position 31 for scanning, after the scanning is completed, the second driving module 2221 drives the conveying structure 2222 to remove the slide from the scanning position 31 to the buffer position 22a, and at the moment, the first driving module 2211 drives the buffer seat 2212 to rotate, so that the slide on the buffer position 22a is converted into a vertical state from the horizontal state, so that the first transfer mechanism 21 transfers the slide in the vertical state to the slide unloading device 40.

For example, the first driving module 2211 may use a motor synchronous belt to drive the pulley to rotate, and the pulley is connected to the buffer seat 2212 through the rotation shaft to drive the buffer seat 2212 to turn.

The second driving module 2221 may drive the slide block to move along the slide rail by a motor through a transmission structure to drive the conveying structure 2222 connected to the slide block into or out of the slide. The transmission structure may adopt any one of a belt transmission mechanism, a chain transmission mechanism, a rack and pinion transmission mechanism, or a screw transmission mechanism to realize the movement of the drive conveying structure 2222.

As an embodiment, the buffer assembly 221 is connected to the transport assembly 222 to be integrated into the same device, which is compact and beneficial to machine miniaturization.

As another embodiment, the buffer assembly 221 is provided separately from the transport assembly 222, and the transport assembly 222 is positioned between the buffer assembly 221 and the scan station 31 to facilitate transfer of slides between the buffer station 22a and the scan station 31.

In some embodiments, as shown in fig. 2 and 14, the scanning device 30 includes a scanning mechanism 32, a scanning platform 33, and a third driving module, where the scanning mechanism 32 is used for scanning a slide located at the scanning position 31, the scanning position 31 is located at the scanning platform 33, the scanning position 31 includes a first scanning position 31a and a second scanning position 31b, the third driving module is connected to the scanning platform 33, and the third driving module is used for driving the scanning platform 33 to move, so that the first scanning position 31a and the second scanning position 31b are alternately docked with the conveying structure 2222; the third driving module is configured to drive the scanning platform 33 to move to enable the second scanning position 31b to be in butt joint with the conveying structure 2222 when the slide scanning on the first scanning position 31a is completed, so that the conveying structure 2222 transfers the slide to be scanned located at the buffer position 22a to the second scanning position 31b, and then drive the scanning platform 33 to move to enable the first scanning position 31a to be in butt joint with the conveying structure 2222, so that the conveying structure 2222 transfers the scanned slide to the buffer position 22a. In this embodiment, by setting the first scanning position 31a and the second scanning position 31b, interference between moving out of the scanned slide and moving in of the slide to be scanned can be avoided, and working efficiency is improved.

The third driving module may drive the sliding block to move along the sliding rail through the transmission structure by using the motor to drive the scanning platform 33 connected to the sliding block to move horizontally, and it is understood that the third driving module may include two sets of driving structures, each set of driving structure includes the motor, the transmission structure, the sliding block and the sliding rail, so as to realize the movement in two directions perpendicular to each other in the horizontal direction, where the sliding rail of one set of driving structure may be disposed on the sliding block of the other set of driving structure and perpendicular to the sliding rail of the other set of driving structure. The transmission structure may adopt any one of a belt transmission mechanism, a chain transmission mechanism, a rack and pinion transmission mechanism, or a screw transmission mechanism to realize driving of the movement of the scanning platform 33.

In some embodiments, as shown in fig. 8, the sample image scanning apparatus 100 further includes a slide recognition device 50, and the first transfer mechanism 21 is configured to transfer the slide to the slide recognition device 50 for identification and/or front-back recognition, and then from the slide recognition device 50 to the buffer location 22a. In this embodiment, the slide recognition device 50 may be separately disposed around the buffer seat 2212, and the camera 51 and the light barrier 52 are disposed on two sides of the buffer seat 22a, so that the slide is photographed by the camera 51 to detect whether the slide is reversed or not and obtain the sample information on the slide.

Optionally, the slide identifying device 50 may be integrally connected to the buffer seat 2212, where the slide identifying device 50 is disposed corresponding to the buffer position 22a, and the slide identifying device 50 is used for identifying the identity and/or front and back of the slide on the buffer position 22a when the slide on the buffer position 22a is in a vertical state. In this embodiment, the camera 51 and the light barrier 52 are mounted on the buffer seat 2212 and are respectively located at two sides of the buffer position 22a, and the slide is shot by the camera 51 to obtain sample information on the slide while detecting whether the slide is reversely placed.

Optionally, a slide recognition device 50 may also be disposed on the scanning platform 33, where the slide recognition device 50 is disposed corresponding to the scanning position 31 and is used to identify and/or identify the front and back of the slide located at the scanning position 31. In this embodiment, the camera 51 and the light barrier 52 are disposed on the scanning platform 33 and are respectively located at two sides of the scanning position 31, and the slide is photographed by the camera 51, so as to obtain the sample information on the slide while detecting whether the slide is reversely placed.

In some embodiments, as shown in fig. 8, the sample image scanning apparatus 100 further includes a rotation mechanism 60, the rotation mechanism 60 being used to drive the slide in rotation to adjust the slide to the front. In this embodiment, the rotating mechanism 60 is connected to the buffer 2212, and is used for driving the slide in the vertical state on the buffer 2212 to horizontally rotate, so as to change the orientation of the slide, so that the slide faces upwards after the buffer 2212 is turned to be in the horizontal state. Illustratively, the rotating mechanism 60 includes a rotating base 61 having a detent for receiving a slide in a vertical state for changing the orientation of the slide, and a rotating motor for driving the rotating base to rotate horizontally.

In some embodiments, as shown in fig. 9, the transfer mechanism 12 includes a pushing structure 121 and a fourth driving module 122, the pushing structure 121 is used for transferring the first slide basket 200, the fourth driving module 122 is connected to the pushing structure 121, and the fourth driving module 122 is used for driving the pushing structure 121 to drive the first slide basket 200 to reciprocate along the first track 11. In this embodiment, the pushing structure 121 is configured to receive the first slide basket 200 loaded with slides, and the fourth driving module 122 drives the pushing structure 121 to drive the first slide basket 200 to move to the middle position 111 along the first track 11, so that the first transfer mechanism 21 transfers the slides to the scanning position 31 for scanning.

Illustratively, as shown in fig. 9, the pushing structure 121 includes a first pushing portion 1211 and a second pushing portion 1212 that are disposed opposite to each other, and the first pushing portion 1211 and the second pushing portion 1212 are disposed at intervals along the extending direction of the first rail 11 for pushing the first slide basket 200 along the first rail 11. In the present embodiment, the first pushing part 1211 is for abutting one side of the first slide basket 200 to push the first slide basket 200 to the middle index 111, and the second pushing part 1212 is for abutting the other side of the first slide basket 200 to push the first slide basket 200 out of the middle index 111. The fourth driving module 122 includes a motor and a transmission assembly, the transmission assembly is connected with the pushing structure 121, and the motor is used for driving the transmission assembly to drive the pushing structure 121 to move along the first track 11, so as to facilitate the transfer of the first slide basket 200. The transmission assembly may adopt any one of a belt transmission mechanism, a chain transmission mechanism, a gear rack transmission mechanism or a screw transmission mechanism, so as to drive the pushing structure 121 to push the first slide basket 200 to move.

In some embodiments, as shown in fig. 9, the slide includes a conventional slide, and further includes an emergency slide and/or a review slide, the first slide basket 200 is at least used for accommodating the conventional slide, the transfer mechanism 12 further includes an accommodating part 123, the accommodating part 123 is connected to the pushing structure 121 or the fourth driving module 122, the accommodating part 123 is used for accommodating the emergency slide and/or the review slide requiring review, and the fourth driving module 122 is further used for driving the accommodating part 123 to reciprocate along the first track 11 to transfer the emergency slide and/or the review slide. In this embodiment, the accommodating part 123 may be disposed parallel to the pushing structure 121 along the extending direction of the first track 11, so that one fourth driving module 122 may drive the accommodating part 123 and the pushing structure 121 to move synchronously, and not only can transport conventional slides but also can transport emergency slides and/or review slides through the same first track 11 and the fourth driving module 122.

Typically, the normal sequence of the conventional slide is used for detecting the sample slide, the emergency slide is used for detecting the sample slide with priority, and the re-diagnosis slide is used for scanning the sample slide with abnormal structure and needing re-diagnosis. The second review slide comprises a first review slide and a second review slide, and specifically, the first review slide is taken out of the second review slide after abnormal scanning, and manual microscopic examination or automatic microscopic examination is carried out on other equipment; when the scanning is abnormal, according to the sample code of the scanning abnormality, the same sample is found, a new slide coated with the same sample is prepared by a slide making instrument, and the slide which is sent into the sample image scanning equipment 100 and subjected to microscopic examination by the scanning device 30 is a second revising slide.

In some embodiments, as shown in fig. 7, the first track 11 is further provided with a picking and placing position 113, the picking and placing position 113 is used for placing an emergency slide or a taking and placing compound slide by a user, and the fourth driving module 122 is further used for driving the accommodating part 123 to move along the first track 11 between the transferring position 111 and the picking and placing position 113, so that the user can place the emergency slide or the taking and placing compound slide through the picking and placing position 113. In this embodiment, the user may place the emergency slide or the second review slide through the taking and placing position 113, and may also take out the first review slide through the taking and placing position 113.

In some embodiments, the controller 70 is configured to control the transfer mechanism 12 to move out of the central index 111 to the pick-and-place location 113 for the emergency slide to be placed into the receptacle 123 when the emergency push instruction is received, and to control the transfer mechanism 12 to transfer the emergency slide from the pick-and-place location 113 to the central index 111 and to control the scheduler 20 to transfer the emergency slide from the central index 111 to the scanning location 31 when the emergency push instruction is received. In this embodiment, the controller 70 can control the transfer mechanism 12 and the scheduler 20 to perform priority treatment on the emergency slide when the emergency slide needs to be inserted, so that the detection efficiency is high.

In some embodiments, the controller 70 is configured to control the scheduler 20 to transfer the first review slide at the corresponding position in the sample image scanning apparatus 100 into the receptacle 123 located at the middle index 111 and control the transfer mechanism 12 to transfer the first review slide from the middle index 111 to the pick-and-place position 113 when receiving the review push-out command. In this embodiment, when the slide scanning abnormality needs to be taken out for manual review or automatic microscopy on other devices, the controller 70 controls the scheduling device 20 to cooperate with the transfer mechanism 12 to transfer the first review slide to the taking and placing position 113, so as to facilitate taking out for manual review or automatic microscopy on other devices.

In some embodiments, the controller 70 is configured to control the transfer mechanism 12 to move out of the middle index 111 to the pick-and-place position 113 when receiving the review push command, to transfer the second review slide to the middle index 111 after the second review slide is placed in the receptacle 123 or the first slide basket 200 through the pick-and-place position 113, and to control the scheduler 20 to transfer the second review slide from the middle index 111 to the scan position 31. In this embodiment, the second review slide is specifically a slide in which, when the scan is abnormal, a sample code corresponding to the scan abnormality is used to find the same sample, a new slide coated with the same sample is prepared by slide preparation, and the new slide is sent into the sample image scanning apparatus 100 and subjected to microscopic examination by the scanning device 30, and the transfer mechanism 12 is controlled by the controller 70 to cooperate with the scheduling device 20 to transfer the second review slide to the scanning position 31 for scanning, so as to obtain a review result of the same sample.

In some embodiments, as shown in fig. 10, the receptacle 123 includes at least one first receptacle 1231, the first receptacle 1231 for receiving an emergency slide; and/or, the accommodating piece 123 comprises at least one second accommodating groove 1232, and the second accommodating groove 1232 is used for accommodating the first review slide. In this embodiment, the emergency slide can be placed by the first receiving groove 1231, the first review slide can be placed by the second receiving groove 1232, confusion of the emergency slide and the first review slide is avoided, and meanwhile, the emergency slide is prevented from being polluted by the mirror oil on the first review slide, wherein the second review slide is a remade sample slide without the mirror oil, and can be placed in the first receiving groove 1231 or the first slide basket 200, and then fed by the transfer mechanism 12.

In some embodiments, as shown in fig. 10, the accommodating part 123 includes a first accommodating groove 1231 and a second accommodating groove 1232, where the first accommodating groove 1231 and the second accommodating groove 1232 are separated, so as to set a preset distance for a user to take and place a slide, and facilitate the user operation.

In some embodiments, slide transfer device 10 further includes a controller 70, controller 70 for controlling transfer mechanism 12 to move a first distance along first track 11 when an emergency instruction is received such that the position of first receiving slot 1231 corresponds to pick-and-place 113, and/or controller 70 for controlling transfer mechanism 12 to move a second distance along first track 11 when a re-diagnosis instruction is received such that the position of second receiving slot 1232 corresponds to pick-and-place 113. In this embodiment, the first accommodating groove 1231 and the second accommodating groove 1232 are arranged at intervals along the extending direction of the first track 11, so that the distance between the first accommodating groove 1231 and the picking and placing position 113 is different from the distance between the second accommodating groove 1232 and the picking and placing position 113, the distance from the first accommodating groove to the picking and placing position 113 is a first distance, the distance from the second accommodating groove to the picking and placing position 113 is a second distance, the transferring mechanism 12 provides driving force through a motor, and the moving distance of the transferring mechanism 12 can be controlled through the moving steps of the motor so as to drive the first accommodating groove 1231 or the second accommodating groove 1232 to correspond to the picking and placing position 113 according to different instructions.

In some embodiments, as shown in fig. 11, the slide unloading device 40 includes a slide receiving bin 41, the slide receiving bin 41 having a plurality of slots 411 for fitting slides, and the scheduler 20 is configured to insert scanned slides into the slots 411. In the present embodiment, the placement of the slide can be facilitated by the provision of the slot 411. Illustratively, a plurality of rows of slots 411 may be provided in the slide receiving bin 41 in an orderly arrangement to facilitate positioning of the slides.

It should be noted that the slide housing chamber 41 is not limited to the slot 411 provided to house slides, and for example, in other embodiments, the slide housing chamber 41 has a plurality of housing positions for housing slide baskets, and the slide transfer mechanism is used to transfer scanned slides into slide baskets of the housing positions. In this embodiment, a plurality of empty slide baskets can be placed in advance in the accommodation chamber 41, and when the slide baskets are fully loaded, the slide baskets and the scanned slides of the slide baskets are taken out together, so that the slide can be unloaded in batches.

In some embodiments, as shown in fig. 2, since the sample needs to be dripped on the glass slide when scanning in the sample image scanning apparatus 100, the sample image scanning apparatus 100 further includes a glass oil receiving mechanism 140, where the glass oil receiving mechanism 140 is disposed below the glass slide accommodating bin 41, and the glass oil receiving mechanism 140 is used to receive the glass oil dripped during the scanning process or the transfer process after completing the scanning. In this embodiment, the mirror oil receiving mechanism 140 may employ a receiving container with an open top to receive the dripped mirror oil, and the receiving container may employ a retractable structure to facilitate the withdrawal from the sample image scanning apparatus 100 to recover the mirror oil.

Illustratively, the cross-sectional area of the opening of the receiving container is greater than or equal to the area covered by all actions of the scanning device 30 and the scheduler 20 within the sample image scanning apparatus 100 to transfer slides to cover the travel of all slides with added mirror oil, avoiding contamination of the apparatus by the mirror oil.

In some embodiments, as shown in fig. 9, the sample image scanning apparatus 100 further includes a sample introduction device 80, the sample introduction device 80 includes a second rail 81 and a first pushing mechanism 82, the second rail 81 is connected to the first rail 11, the first pushing mechanism 82 is used for driving the first slide basket 200 loaded with slides to move along the second rail 81 to transfer the first slide basket 200 to the first rail 11, wherein the second rail 81 is disposed perpendicular to the first rail 11, and/or the second rail 81 is used for splicing with a pusher, and the pusher is used for transferring the first slide basket 200 loaded with slides to the second rail 81. In this embodiment, the second rail 81 may be spliced with the slide pusher to realize automatic feeding of the first slide basket 200 loaded with slides, but of course, the second rail 81 may also be directly put on the first slide basket 200 loaded with slides to the second rail 81 by manual work without being spliced with the slide pusher.

In some embodiments, as shown in fig. 9, the sample image scanning apparatus 100 further includes a sample ejection device 90, the sample ejection device 90 includes a third rail 91 and a second pushing mechanism 92, the recovery site 112 interfaces with the third rail 91, and the second pushing mechanism 92 is used to push the empty first slide basket 200 located at the recovery site 112 to the third rail 91. In this embodiment, the third rail 91 is used for placing the empty first slide basket 200, the second rail 81 and the third rail 91 are perpendicular to the first rail 11, and the second rail 81 and the third rail 91 are arranged on the same side of the first rail 11 in parallel, so that the first rail 11, the second rail 81 and the third rail 91 enclose to form a U-shaped structure, thereby shortening the moving path of the first slide basket 200, improving the working efficiency, having a compact structure and being beneficial to miniaturization of equipment.

Of course, the recycling bin 112 may also be spliced with a recycling device of an external apparatus, so that the recycling device of the external apparatus receives the empty first slide basket 200, or alternatively, the recycling bin 112 is spliced with a slide pusher, which is used for receiving the prepared slide into the empty first slide basket 200 and feeding the first slide basket 200 loaded with the slide into the sample image scanning apparatus 100, so as to realize recycling of the slide basket.

In some embodiments, as shown in fig. 1-7, the sample image scanning device 100 further includes a housing 110, a first partition 120, and a second partition 130, the housing 110 including a top plate 1101 and a bottom plate 1102 disposed opposite to each other, a front plate 1103 and a rear plate 1104 disposed opposite to each other, a first side plate 1105 and a second side plate 1106 connected opposite to each other between the front plate 1103 and the rear plate 1104, the front plate 1103 including a first front plate 1103a and a second front plate 1103b, the second front plate 1103b being located on a side of the first front plate 1103a away from the rear plate 1104; a first space 110a is formed between the first front plate 1103a and the rear plate 1104, a second space 110b is formed between the first front plate 1103a and the second front plate 1103b, the first partition 120 is disposed in the housing 110, the first space 110a is divided into a third space 110c above the first partition 120 and a fourth space 110d below the first partition 120, the second partition 130 is disposed in the housing 110 and below the first partition 120, and divides the fourth space 110d into a fifth space 110e above the second partition 130 and a sixth space 110f below the second partition 130, wherein the slide unloading device 40 can move out of the fourth space 110d from the first front plate 1103a or the first side plate 1105 or the second side plate 1106, or into the fourth space 110d, and the height of the slide unloading device 40 is higher than that of the transfer device 10, the transfer device 10 is used for transferring the first basket 200 loaded with slides to the fourth space 110d or moving the empty first basket 200 out of the fourth space 110d, the scanning device 30 and the fourth space 20 d are disposed in the scanning device 31 to complete the scanning device for moving slides from the first front plate 1105 or the second side plate 1106 to the fourth space 110 d. In this embodiment, the first space 110a at the rear side of the housing 110 is divided into the third space 110c, the fifth space 110e and the sixth space 110f, which are sequentially arranged from top to bottom, so as to vertically arrange, reduce the transverse size, thereby reducing the occupied area of equipment, improving the space utilization rate, and the first space 110a is arranged at the adjacent side of the second space 110b, which is beneficial to taking and placing the slide, and meanwhile, the height of the slide unloading device 40 is higher than that of the transfer device 10, so that mutual interference between the sample injection of the slide and the unloading of the slide is avoided, and the user operation is facilitated.

The transferring device 10 is located in the second space 110b and partially extends to the sixth space 110f, the portion of the transferring device 10 extending to the sixth space 110f is the middle position 111, the scanning position 31 and the middle position 111 are both located in the sixth space 110f, the dispatching device 20 is located in the fifth space 110e and extends to the sixth space 110f, the slide unloading device 40 can move out of the sixth space 110f or move into the sixth space 110f from the first front plate 1103a or the first side plate 1105 or the second side plate 1106, so that the dispatching device 20 can transfer slides between the middle position 111, the scanning position 31 and the slide unloading device 40, the scanning device 30 is located in the fifth space 110e and extends to the sixth space 110f, so that slides on the scanning position 31 of the sixth space 110f can be scanned, and the middle position 111, the scanning position 31 and the slide unloading device 40 are located in the same area, thereby being beneficial to smooth transfer of slides and improving transfer efficiency of slides.

In some embodiments, as shown in fig. 6, the sample image scanning apparatus 100 further includes a housing 110 having an access area within the housing 110, one side of the housing 110 having an access opening in communication with the access area, and an access cover for closing or opening the access opening, at least one of the scanning device 30 and the scheduling device 20 being partially or entirely within a viewable range through the access opening when the access cover is opened. In this embodiment, can open the access hole through the access cover to expose the access area, the maintainer can operate and maintain scanning device 30, dispatch device 20 etc. in the access area through the access hole, in this application, under the condition that scanning device 30 breaks down, accessible access hole maintains scanning device 30, reduces the time that the organism was used of dismantling, and it is convenient to maintain, ensures the effective operation of complete machine.

It should be noted that, the sample feeding manner of the emergency slide is not limited to the placement of the receiving member 123 on the transfer mechanism 12, for example, in other embodiments, as shown in fig. 2 and 4, the sample image scanning apparatus 100 further includes an emergency device 170 that is disposed independently, including a fourth rail 171 and a transfer mechanism 172, where the transfer mechanism 172 includes a carrying structure and a fifth driving module, the carrying structure is used for placing the second slide basket 300 loaded with the emergency slide, and the fifth driving module is used for driving the carrying mechanism to move on the fourth rail so as to move the second slide basket 300 loaded with the emergency slide into the waiting position of the sample image scanning apparatus 100, and the scheduling device 20 is further used for transferring the slide in the second slide basket 300 located in the waiting position to the scanning position 31. In this embodiment, the emergency device 170 and the transfer device 10 are separately provided, and the emergency device 170 is used to process the emergency slide when the emergency slide needs to be inserted, so that the transfer mechanism 12 does not need to wait for entering the emergency mode from the normal mode, and the operation of the user is facilitated.

Illustratively, the fifth drive module includes a motor and a drive assembly coupled to the carrier structure, the motor for driving the drive assembly to move the carrier structure along the fourth track 171 to facilitate transfer of the second slide basket 300 loaded with emergency slides. The transmission assembly can adopt any one of a belt transmission mechanism, a chain transmission mechanism, a gear rack transmission mechanism or a screw rod transmission mechanism to drive the bearing structure to move.

In some embodiments, the sample image scanning apparatus 100 further comprises a controller 70, the controller 70 being configured to control the fifth drive module to drive the carrier structure to move to the loading position for loading the second slide basket 300 loaded with the emergency slide into the carrier structure when the emergency command is received, and to control the fifth drive module to move from the loading position to the waiting position when the loading position of the second slide basket 300 on the carrier structure is detected, and then control the scheduling device 20 to transfer the slide in the second slide basket 300 located in the waiting position to the scanning position 31. In this embodiment, the controller 70 can control the emergency treatment device 170 and the scheduling device 20 to perform priority treatment on the emergency treatment slide when the emergency treatment slide needs to be inserted, so that the detection efficiency is high.

It should be noted that the feeding and removing manner of the review slide is not limited to the arrangement of the receiving member 123 on the transfer mechanism 12, for example, in other embodiments, as shown in fig. 3 and 5, the sample image scanning apparatus 100 further includes an independently arranged review device 180, including a carrier 181 and a sixth driving module 182, the carrier 181 is used for placing the review slide that needs to be reviewed, the scheduling device 20 is further used for transferring the first review slide that needs to be manually reviewed to the carrier 181 or transferring the second review slide that needs to be sent to the scanning position 31 for scanning from the carrier 181 to the scanning position 31, and the sixth driving module 182 is used for driving the carrier 181 to move the first review slide out of the sample image scanning apparatus 100 or move the second review slide into the sample image scanning apparatus 100. In this embodiment, the review device 180 and the transfer device 10 are separately provided, and when the first review slide needs to be taken out or the second review slide needs to be sent in, the sixth driving module 182 can drive the carrier 181 to move, so that the transfer mechanism 12 does not need to wait for entering the review mode from the normal mode, and the operation is convenient.

The sixth driving module 182 is configured to drive the carrier 181 to rotate, so that the carrier 181 is at least partially exposed to the sample image scanning apparatus 100, and a user can take out a first review slide on the carrier 181 or send a second review slide to the carrier 181. In this embodiment, the carrier 181 is rotated to move out of or into the sample image scanning apparatus 100 in a rotating manner, so as to reduce the moving stroke, improve the working efficiency, reduce the size, save the space, and facilitate the miniaturization of the machine. The sixth driving module 182 may drive the pulley to rotate by using a motor synchronous belt, and the pulley is connected to the bearing seat 181 through a rotation shaft to drive the bearing seat 181 to rotate.

In some embodiments, the sample image scanning apparatus 100 further includes a controller 70, where the controller 70 is configured to control the scheduler 20 to transfer a first review slide at a corresponding position in the slide unloading device 40 into the carrier 181 when receiving the review push command, and control the sixth driving module 182 to drive the carrier 181 to move so as to move the first review slide out of the sample image scanning apparatus 100, and/or the controller 70 is configured to control the sixth driving module 182 to drive the carrier 181 to move so as to be exposed to the sample image scanning apparatus 100 when receiving the review push command, so that a user can put a second review slide into the carrier 181, and to control the carrier 181 to move so as to move the second review slide into the sample image scanning apparatus 100 when detecting that the second review slide is put on the carrier 181, and to control the scheduler 20 to transfer the second review slide from the carrier 181 to the scanning position 31. In the present embodiment, the above arrangement enables the controller 70 to control the review device and the scheduling device 20 to perform priority treatment on the review slide when the first review slide needs to be taken out or the second review slide needs to be fed, so that the detection efficiency is high.

In some embodiments, the controller 70 is communicatively coupled to the sample injection device 80, the transfer device 10, the scheduler 20, and the scanner 30, the controller 70 being configured to: detecting whether the buffer bit 22a is empty; when the buffer position 22a is empty, controlling the first transfer mechanism 21 to pick up a slide from the first slide basket 200 and transfer the slide to the buffer position 22a; the second transfer mechanism 22 is controlled to transfer the slide to the scanning device 30 for scanning to obtain a scan result.

In some embodiments, the slides include a conventional slide and an abnormal slide, the first slide basket 200 is at least used to carry the conventional slide, the abnormal slide includes a review slide and/or an emergency slide, the sample image scanning apparatus 100 further includes a review device and/or a review device for feeding the review slide, the emergency device is used to feed the second slide basket 300 carrying the emergency slide, or the transfer device 10 is used to feed the emergency slide.

The controller 70 is also configured to: detecting whether the buffer position 22a is empty when the first transfer mechanism 21 is detected to feed the first slide basket 200, and controlling the first transfer mechanism 21 to transfer the normal slide from the first slide basket 200 to the buffer position 22a when the buffer position 22a is empty; when the re-examination device 180 is detected to feed the re-examination slide, detecting whether the buffer position 22a is empty, and when the buffer position 22a is empty, controlling the first transfer mechanism 21 to transfer the re-examination slide from the re-examination device 180 to the buffer position 22a; detecting whether the buffer position 22a is empty when the emergency treatment device 170 is fed with the second slide basket 300 loaded with the emergency treatment slides or the transfer device 10 is fed with the emergency treatment slides, and controlling the first transfer mechanism 21 to transfer the emergency treatment slides to the buffer position 22a when the buffer position 22a is empty; wherein, the priority of the first transfer mechanism 21 for transferring emergency slides is higher than that of the second transfer mechanism 21 for transferring the second slide, and the priority of the first transfer mechanism 21 for transferring the second slide is higher than that of the conventional slide.

Specifically, the controller 70 is configured to control the transferring device 10, the scheduling device 20, and the scanning device 30 to execute multiple working states jointly or independently, and dynamically detect whether resources of the transferring device 10, the scheduling device 20, and the scanning device 30 related to the working states can be acquired in the process of executing any working state, if so, acquire the resources related to the working states to continue executing the working states, and if not, the controller 70 transitions to control to execute other working states.

In some embodiments, the plurality of operating states includes at least a first operating state in which the second transfer mechanism 22 is in slide with the first scanning position 31a or the second scanning position 31b and a second operating state in which the second transfer mechanism 22 is out of slide with the first scanning position 31a or the second scanning position 31 b.

It should be appreciated that when a certain control unit of the controller 70 acquires the resources of any device and controls the device, the device cannot be occupied and controlled by other control units, and other control units may detect that the device cannot acquire the resources of the device, so that other control units cannot intervene in controlling the device. And only when the controller 70 occupying the resources of the device releases the resources of the device, the other control units can detect that the resources of the device can be acquired and occupy the resources thereof for control.

Based on this, the sample image scanning apparatus 100 provided in the embodiment of the present application is controlled by a plurality of control units to execute different working states, and any control unit detects whether the corresponding device can occupy the resource of the device before controlling the corresponding device, and uses the resource to avoid other control units to control the device under the condition that the resource can be occupied, so that the time sequence conflict between different working states when the various working states of the sample image scanning apparatus 100 are combined is effectively avoided, and the working of the sample image scanning apparatus 100 such as placing a slide into the first scanning position 31a or the second scanning position 31b, taking the slide out of the first scanning position 31a or the second scanning position 31b, transferring the slide, recycling the slide and performing microscopic scanning on the slide is ensured to be independently and orderly performed.

Further, the controller 70 dynamically detects whether the device resource related to the working state can be obtained during any working state executing process, and if not, the controller 70 changes to control to execute other working states. Similarly, the controller 70 dynamically detects whether or not the device resources related to other working states can be acquired when it is controlled to execute other working states, and if so, acquires the resources related to the working states to continue executing the working states.

It is easy to understand that, the present sample image scanning apparatus 100 can timely control other idle devices to perform related operations through the logic of the controller 70, so as to fully utilize each device in the sample image scanning apparatus 100, and efficiently complete the processes of transferring, microscopic examination scanning, recycling, and the like, for a batch of slides.

In some embodiments, the control of the controller 70 to perform the first operating state includes:

detecting whether the resources of the scanning device 30 and the second transfer mechanism 22 can be acquired, and if so, acquiring the resources of the scanning device 30 and the second transfer mechanism 22 and detecting the state of the second transfer mechanism 22;

if the second transfer mechanism 22 is in a state to be fed in which the slide accommodated in the buffer position 22a is to be fed to the first scanning position 31a or the second scanning position 31b, detecting the state of the first scanning position 31a or the second scanning position 31 b;

if the first scanning position 31a or the second scanning position 31b is in the empty state, controlling the second transfer mechanism 22 to cooperate with the scanning device 30 to feed the slide to the corresponding scanning position;

after feeding the slide to the corresponding scanning position, the second transfer mechanism 22 is set to the empty state, and the corresponding scanning position is set to the state to be scanned;

The resources of the scanning device 30 and the second transfer mechanism 22 are released.

For example, the control to execute the first operation state is specifically executed by thread control of the first control unit of the controller 70.

When the controller 70 controls the first operating state, it specifically detects whether the resources of the scanning device 30 and the second transferring mechanism 22 can be acquired, if so, the resources of the scanning device 30 and the second transferring mechanism 22 are acquired, and then detects the state of the second transferring mechanism 22. If the second transfer mechanism 22 is currently in the state to be fed, the state of the first scanning bit 31a or the second scanning bit 31b is detected. It should be appreciated that the to-be-fed state is used to characterize the buffer station 22a holding a slide, and that the slide held in the buffer station 22a is waiting to be fed to either the first scanning station 31a or the second scanning station 31b for a microscopic scan.

After detecting one of the states of the first scanning position 31a and the second scanning position 31b, if the first scanning position 31a or the second scanning position 31b is detected to be in the empty state, the controller 70 controls the second transfer mechanism 22 to cooperate with the scanning device 30 to feed the slide to the corresponding scanning position, and after feeding the slide to the corresponding scanning position, sets the second transfer mechanism 22 to the empty state while setting the corresponding scanning position to the to-be-scanned state, and then the controller 70 releases the resources of the scanning device 30 and the second transfer mechanism 22 to release the occupation of the scanning device 30 and the second transfer mechanism 22.

It should be noted that, the corresponding scan bit is one of the first scan bit 31a and the second scan bit 31b, and when one of the scan bits is determined to be in the to-be-fetched state, the corresponding scan bit can be determined.

In some embodiments, the control of the controller 70 to perform the second operating state includes:

detecting whether the resources of the scanning device 30 and the second transferring mechanism 22 can be acquired, and if so, acquiring the resources of the scanning device 30 and the second transferring mechanism 22, and detecting the states of the second transferring mechanism 22, the first scanning bit 31a and the second scanning bit 31 b;

when the second transfer mechanism 22 is detected to be in the empty state and at least one of the first scanning position 31a and the second scanning position 31b is in the state to be picked up, determining the corresponding scanning position and the state of the slide located at the corresponding scanning position, wherein the state of the slide comprises one of the state to be recovered and the state to be rotated;

at least the second transfer mechanism 22 is controlled to cooperate with the scanning device 30 to transfer the slide to the second transfer mechanism 22, and the corresponding scanning position is set to be in a vacant state;

setting the second transfer mechanism 22 to a recovery instruction state according to the state to be recovered, or setting the second transfer mechanism 22 to a rotation instruction state according to the state to be rotated;

Releasing the resources of the second transfer mechanism 22 and the scanning device 30.

For example, the control execution of the second operation state is specifically executed by thread control of the first control unit of the controller 70.

Specifically, when controlling the second operation state, the controller 70 first detects whether the resources of the scanning device 30 and the second transfer mechanism 22 can be acquired, and if so, acquires the resources of the scanning device 30 and the second transfer mechanism 22, and detects the states of the second transfer mechanism 22, the first scanning bit 31a, and the second scanning bit 31 b. When the second transfer mechanism 22 is detected to be in the empty state and at least one of the first scanning position 31a and the second scanning position 31b is in the waiting state, the controller 70 determines the corresponding scanning position and the state of the slide located in the corresponding scanning position.

It should be noted that, the corresponding scan bit is one of the first scan bit 31a and the second scan bit 31b, and when one of the scan bits is determined to be in the state of being taken, the corresponding scan bit is determined to be the corresponding scan bit.

It should be noted that, the manner in which the controller 70 determines the state of the slide may be a state in which the controller 70 directly reads the slide setting, and the state of the slide specifically includes one of the state to be recovered and the state to be rotated. The slide being in a state to be recovered characterizes the operation of the specimen image scanning apparatus 100 that has performed microscopic scanning on the slide, the slide being to be recovered; the slide is in a state to be rotated to represent that the slide is abnormal in posture, and the slide is to be rotated.

After determining the state of the slide at the scan position, the controller 70 controls at least the second transfer mechanism 22 to transfer the slide to the buffer position 22a of the second transfer mechanism 22 in cooperation with the scanning device 30, setting the corresponding scan position to the empty state. Then, the state of the second transfer mechanism 22 is set according to the state of the slide at the corresponding scanning position, and then the resources of the second transfer mechanism 22 and the scanning device 30 are released. Wherein the controller 70 may set the state of the second transfer mechanism 22 to the recovery instruction state or the rotation instruction state, and then release the empty state of the second transfer mechanism 22.

Specifically, if the slide is in a state to be recovered, the controller 70 sets the second transfer mechanism 22 to a recovery instruction state; if the slide is in a state to be rotated, the controller 70 sets the second transfer mechanism 22 to a rotation indicating state. The recovery instruction state and the rotation instruction state are used for instructing the controller 70 to control the recovery and rotation of the slide.

The controller 70 provided in the embodiment of the present application may adopt an existing PLC programmable logic controller 70, a DDC direct digital controller 70, or a single chip microcomputer control system, etc. to implement the above control process.

The embodiment of the application also provides a sample detection system, which comprises a slide making device, a first detection device, a control device, a display device and the sample image scanning device 100, wherein the first detection device, the slide making device and the sample image scanning device 100 are electrically connected with the control device, the first detection device is used for detecting a sample and outputting a first detection result, the slide making device is used for preparing a sample slide, the sample image scanning device 100 is used for receiving and scanning the sample slide prepared by the slide making device, when the first detection result is abnormal, the control device controls the slide making device to prepare the sample slide and controls the sample slide to be conveyed to the sample image scanning device 100, the image scanning device receives and scans the sample slide and outputs a scanning result, and the display device displays the first detection result and the scanning result; wherein the sample is any one of a blood sample and a gynecological sample. The sample detection system provided in the embodiment of the present application has all the beneficial effects brought by the technical solution of any embodiment of the sample image scanning device 100, and is not described herein in detail.

Illustratively, when the sample is a blood sample, the first detection device is a blood cell analysis device, such as: blood routine and specific protein detection all-in-one machine, blood routine detector or specific protein detector, etc.; when the sample is a gynecological sample, the first detection equipment is at least one of dry chemical detection equipment, dry chemical detection, dry dyeing and microscopic examination integrated machine and dry dyeing and microscopic examination equipment; when the sample is a blood sample or a gynecological sample, the slide making equipment is a slide pushing module, a dyeing module or a slide-dyeing integrated module.

The embodiment of the application also provides a liquid-based sample detection system, including film-making equipment, controlling means, display device and foretell sample image scanning equipment 100, film-making equipment and sample image scanning equipment 100 and controlling means electricity are connected, and the film-making equipment is used for preparing liquid-based sample slide, and sample image scanning equipment 100 is used for receiving and scanning the liquid-based sample slide that film-making equipment prepared, and controlling means control film-making equipment prepares liquid-based sample slide and control and carries liquid-based sample slide to sample image scanning equipment 100, and sample image scanning equipment 100 receives and scans liquid-based sample slide and output scanning result, and display device shows the scanning result. In this embodiment, when the sample is a cervical sample, the sample detection system may be devoid of a first detection device, and the slide making device may or may not include a staining module. The liquid-based sample detection system provided in the embodiment of the present application has all the beneficial effects brought by the technical solution of any embodiment of the sample image scanning device 100, and is not described herein in detail.

While the invention has been described with reference to certain preferred embodiments, it will be understood by those skilled in the art that various changes and substitutions of equivalents may be made and equivalents will be apparent to those skilled in the art without departing from the scope of the invention. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.

Claims

1. A sample image scanning apparatus, comprising:

2. The sample image scanning apparatus of claim 1, wherein said scheduling means comprises a first transfer mechanism and a second transfer mechanism, said second transfer mechanism having a buffer bit;

the first transfer mechanism is used for transferring the slide positioned in the transfer position to the buffer position;

the second transfer mechanism is used for transferring the slide to be scanned, which is positioned in the buffer position, to the scanning position, and transferring the slide which is scanned to the buffer position, and the first transfer mechanism is also used for transferring the slide which is scanned to the slide unloading device from the buffer position;

Wherein a projection of a moving path of the first transfer mechanism in a vertical direction covers the middle index, the buffer position, and a region where the slide unloading device is located, so that one of the first transfer mechanisms can transfer the slide between the middle index, the buffer position, and the slide unloading device.

3. The specimen image scanning apparatus of claim 2, wherein the index, the slide unloading device, and the buffer are arranged in a horizontal direction below a moving path of the first transfer mechanism.

4. The specimen image scanning apparatus as claimed in claim 2, wherein the slide has a vertical state at the time of sampling and a horizontal state at the time of scanning, the first transfer mechanism being for transferring the slide in the vertical state;

the second transfer mechanism includes:

the buffer assembly comprises a first driving module and a buffer seat for bearing glass slides, wherein the buffer seat is arranged on the buffer seat, and the first driving module is used for driving the buffer seat to rotate so as to enable the glass slides positioned on the buffer seat to be switched between a vertical state and a horizontal state;

the conveying assembly comprises a second driving module and a conveying structure for conveying the slide, and the second driving module is used for driving the conveying structure to move so as to transfer the slide in a horizontal state between the buffer storage position and the scanning position.

5. The sample image scanning apparatus as recited in claim 4, wherein said scanning means comprises:

a scanning mechanism for scanning the slide at the scanning position;

the scanning platform is arranged on the scanning position, and the scanning position comprises a first scanning position and a second scanning position;

the third driving module is connected to the scanning platform and used for driving the scanning platform to move so as to enable the first scanning position and the second scanning position to be in alternate butt joint with the conveying structure;

and the third driving module is used for driving the scanning platform to move to enable the second scanning position to be in butt joint with the conveying structure when the slide scanning on the first scanning position is completed, so that the conveying structure can transfer the slide to be scanned, which is positioned in the buffer position, to the second scanning position, and then driving the scanning platform to move to enable the first scanning position to be in butt joint with the conveying structure, so that the conveying structure can transfer the slide, which is scanned, to the buffer position.

6. The specimen image scanning apparatus as claimed in claim 2, further comprising slide recognition means, wherein the first transfer mechanism is configured to transfer a slide to the slide recognition means for identification and/or front-back recognition, and then to transfer from the slide recognition means to the buffer position; or alternatively, the process may be performed,

The sample image scanning device further comprises a slide identification device, wherein the slide identification device is arranged corresponding to the buffer position, and when the slide on the buffer position is in the vertical state, the slide identification device is used for carrying out identity identification and/or front and back identification on the slide on the buffer position; or alternatively, the process may be performed,

the sample image scanning device further comprises a slide identification device, wherein the slide identification device is arranged corresponding to the scanning position and is used for carrying out identification and/or front and back identification on the slide positioned at the scanning position.

7. The sample image scanning device of claim 6, further comprising a rotation mechanism for driving the slide in rotation to adjust the slide to the front.

8. The sample image scanning device of claim 1, wherein the transport mechanism comprises:

the pushing structure is used for conveying the first slide basket;

the fourth driving module is connected to the pushing structure and used for driving the pushing structure to drive the first slide basket to move back and forth along the first track.

9. The sample image scanning device of claim 8, wherein said slide comprises a conventional slide, said first slide basket at least for receiving said conventional slide, said slide further comprising an emergency slide and/or a review slide;

the transfer mechanism further comprises a containing piece, the containing piece is connected to the pushing structure or the fourth driving module, the containing piece is used for containing the emergency slide and/or the review slide, and the fourth driving module is further used for driving the containing piece to move back and forth along the first track so as to transfer the emergency slide and/or the review slide.

10. The sample image scanning device of claim 9, wherein the first rail is further provided with a picking and placing position, the picking and placing position is used for a user to put the emergency slide or pick and place the review slide, and the fourth driving module is further used for driving the accommodating part to move along the first rail between the middle position and the picking and placing position so as to put the emergency slide or pick and place the review slide through the picking and placing position.

11. The specimen image scanning device of claim 10, wherein the review slide comprises a first review slide and a second review slide, the specimen image scanning device further comprising a controller;

The controller is used for controlling the transfer mechanism to move out of the transfer position to the picking and placing position when the emergency push-out instruction is received, so that emergency slides can be placed in the accommodating piece, controlling the transfer mechanism to transfer the emergency slides from the picking and placing position to the transfer position when the emergency push-in instruction is received, and controlling the dispatching device to transfer the emergency slides from the transfer position to the scanning position; and/or the number of the groups of groups,

the controller is used for controlling the dispatching device to transfer a first review slide at a corresponding position in the sample image scanning equipment into the accommodating part positioned at the transfer position when receiving a review push-out command, and controlling the transfer mechanism to transfer the first review slide from the transfer position to the picking and placing position; and/or the number of the groups of groups,

the controller is used for controlling the transfer mechanism to move out from the transfer position to the picking and placing position when receiving the re-diagnosis push-in command so that a second re-diagnosis slide can be transferred to the transfer position after being placed into the accommodating piece or the first slide basket through the picking and placing position, and controlling the scheduling device to transfer the second re-diagnosis slide from the transfer position to the scanning position.

12. The sample image scanning apparatus of claim 1, wherein said slide unloading device comprises a slide receiving bin having a plurality of slots for fitting with said slides, said scheduling device for inserting scanned said slides into said slots; or alternatively, the process may be performed,

the slide accommodating bin is provided with a plurality of accommodating positions for accommodating slide baskets, and the slide transferring mechanism is used for transferring scanned slides into the slide baskets of the accommodating positions.

13. The sample image scanning apparatus of claim 1, further comprising a sample introduction device comprising a second rail and a first pushing mechanism, the second rail being connected to the first rail, the first pushing mechanism being configured to drive the first slide basket loaded with slides along the second rail to transfer the first slide basket to the first rail, wherein the second rail is disposed perpendicular to the first rail, and/or wherein the second rail is configured to be spliced with a pusher that is configured to transfer the first slide basket loaded with slides to the second rail; and/or the number of the groups of groups,

The sample image scanning device further comprises a sample outputting device, the sample outputting device comprises a third track and a second pushing mechanism, the recycling position is in butt joint with the third track, the second pushing mechanism is used for pushing the empty first slide basket at the recycling position to the third track, or the recycling position is used for being spliced with the recycling device so as to enable the recycling device to receive the empty first slide basket, or the recycling position is used for being spliced with a slice pushing machine, and the slice pushing machine is used for transferring prepared slides into the empty first slide basket and sending the first slide basket loaded with the slides into the sample image scanning device; and/or the number of the groups of groups,

the sample image scanning device further comprises a shell, a first partition plate and a second partition plate, wherein the shell comprises a top plate, a bottom plate, a front plate, a rear plate, a first side plate and a second side plate, the top plate and the bottom plate are oppositely arranged, the front plate and the rear plate are oppositely arranged, the first side plate and the second side plate are oppositely connected between the front plate and the rear plate, the front plate comprises a first front plate and a second front plate, and the second front plate is positioned on one side, far away from the rear plate, of the first front plate; a first space is formed between the first front plate and the rear plate, a second space is formed between the first front plate and the second front plate, a first partition plate is arranged in the shell and divides the first space into a third space above the first partition plate and a fourth space below the first partition plate, a second partition plate is arranged in the shell and below the first partition plate and divides the fourth space into a fifth space above the second partition plate and a sixth space below the second partition plate, the slide unloading device can move out of the fourth space from the first front plate or the first side plate or the second side plate or into the fourth space, the height of the slide unloading device is higher than that of the transfer device, the transfer device is used for moving a first slide loaded with a slide to the fourth basket or moving an empty slide to the fourth space, the scanning device and the scanning device are arranged in the fourth space, and the scanning device are arranged in the fourth space or the fourth space, and the scanning device is used for moving the slide to the fourth space, and the slide to the fourth space is moved to the fourth space; and/or the number of the groups of groups,

The sample image scanning device further comprises a shell and an access cover, wherein an access area is arranged in the shell, an access hole is formed in one side of the shell, the access hole is communicated with the access area, the access cover is used for closing or opening the access hole, and when the access cover is opened, at least one of the scanning device and the dispatching device is partially or completely located in a visible range through the access hole.

14. The specimen image scanning device of claim 1, wherein the slide includes a conventional slide and an emergency slide, the first slide basket for receiving the conventional slide;

the sample image scanning apparatus further includes:

the emergency treatment device comprises a fourth track and a transfer mechanism, wherein the transfer mechanism comprises a bearing structure and a fifth driving module, the bearing structure is used for placing a second slide basket loaded with emergency treatment slides, the fifth driving module is used for driving the bearing structure to move on the fourth track so as to move the second slide basket loaded with the emergency treatment slides into a waiting position of the sample image scanning device, and the scheduling device is further used for transferring slides in the second slide basket located in the waiting position to the scanning position.

15. The sample image scanning device of claim 14, further comprising:

and the controller is used for controlling the fifth driving module to drive the bearing structure to move to a placement position for placing a second slide basket loaded with emergency slides into the bearing structure when an emergency treatment command is received, controlling the fifth driving module to move from the placement position to the waiting position when the second slide basket is detected to be placed on the bearing structure, and then controlling the dispatching device to transfer slides in the second slide basket positioned in the waiting position to the scanning position.

16. The specimen image scanning apparatus of claim 1, wherein the slide comprises a conventional slide and a review slide, the first slide basket for receiving the conventional slide, the review slide comprising a first review slide to be taken out of the specimen image scanning apparatus for review and/or a second review slide to be sent to the scanning location for scanning; the sample image scanning apparatus further includes:

the second review device comprises a bearing seat and a sixth driving module, wherein the bearing seat is used for placing the second review slide, the scheduling device is further used for transferring the first second review slide to the bearing seat or transferring the second review slide from the bearing seat to the scanning position, and the sixth driving module is used for driving the bearing seat to move so as to move the first second review slide out of the sample image scanning device or move the second review slide into the sample image scanning device.

17. The sample image scanning device of claim 16, wherein the sixth driving module is configured to drive the carrier to rotate so that the carrier is at least partially exposed to the sample image scanning device, so that a user can take out the first review slide on the carrier or send the second review slide into the carrier.

18. The sample image scanning device of claim 16, further comprising:

the controller is used for controlling the dispatching device to transfer a first review slide at a corresponding position in the slide unloading device into the bearing seat when receiving a review push command, controlling the sixth driving module to drive the bearing seat to move so as to move the first review slide out of the sample image scanning device, and/or controlling the sixth driving module to drive the bearing seat to move to be exposed out of the sample image scanning device when receiving the review push command so as to enable a user to put the second review slide into the bearing seat, and controlling the bearing seat to move when detecting that a second review slide is put on the bearing seat, so as to move the second review slide into the sample image scanning device, and controlling the dispatching device to transfer the second review slide from the bearing seat to the scanning position.

19. The sample image scanning device of claim 2, further comprising:

a sample feeding device for feeding the first slide basket loaded with slides;

the controller is in communication connection with the sample injection device, the transfer device, the scheduling device and the scanning device, and is used for:

detecting whether the cache bit is empty or not;

when the buffer storage position is empty, controlling the first transfer mechanism to pick up the slide from the first slide basket and transfer the slide to the buffer storage position;

and controlling the second transfer mechanism to transfer the slide to the scanning device for scanning so as to obtain a scanning result.

20. The sample image scanning apparatus of claim 19, wherein the slides comprise a conventional slide and an abnormal slide, the first slide basket being at least for loading the conventional slide, the abnormal slide comprising a review slide and/or an emergency slide, the sample image scanning apparatus further comprising a review device for feeding the review slide and/or a review device for feeding a second slide basket loaded with the emergency slide;

the controller is further configured to:

Detecting whether the buffer position is empty when the first transfer mechanism is detected to feed the first slide basket, and controlling the first transfer mechanism to transfer the conventional slide from the first slide basket to the buffer position when the buffer position is empty;

when the re-diagnosis device is detected to feed the re-diagnosis slide, detecting whether the buffer position is empty or not, and when the buffer position is empty, controlling the first transfer mechanism to transfer the re-diagnosis slide from the re-diagnosis device to the buffer position;

when the emergency device is detected to feed a second slide basket loaded with emergency slides, detecting whether the buffer position is empty or not, and when the buffer position is empty, controlling the first transfer mechanism to transfer the emergency slides to the buffer position;

the priority of the first transfer mechanism for transferring the emergency slide is greater than that of the second transfer mechanism for transferring the emergency slide, and the priority of the first transfer mechanism for transferring the second slide is greater than that of the conventional slide.

21. A sample detection system, comprising a slide making apparatus, a first detection apparatus, a control device, a display device, and the sample image scanning apparatus according to any one of claims 1 to 20, wherein the first detection apparatus, the slide making apparatus, and the sample image scanning apparatus are electrically connected to the control device, the first detection apparatus is configured to detect the sample and output a first detection result, the slide making apparatus is configured to prepare a sample slide, the sample image scanning apparatus is configured to receive and scan the sample slide prepared by the slide making apparatus, the control device controls the slide making apparatus to prepare a sample slide and controls the sample slide to be transferred to the sample image scanning apparatus when the first detection result is abnormal, the image scanning apparatus receives and scans the sample slide and outputs the scanning result, and the display device displays the first detection result and the scanning result; wherein the sample is any one of a blood sample and a gynecological sample.

22. A liquid-based sample detection system, comprising a slide making apparatus, a control device, a display device, and a sample image scanning apparatus according to any one of claims 1 to 20, wherein the slide making apparatus and the sample image scanning apparatus are electrically connected to the control device, the slide making apparatus is used for preparing a liquid-based sample slide, the sample image scanning apparatus is used for receiving and scanning the liquid-based sample slide prepared by the slide making apparatus, the control device controls the slide making apparatus to prepare a liquid-based sample slide and controls the liquid-based sample slide to be conveyed to the sample image scanning apparatus, the sample image scanning apparatus receives and scans the liquid-based sample slide and outputs the scanning result, and the display device displays the scanning result.