CN116035925A - Feldspar nano ceramic particle abrasive toothpaste containing simulated enamel mechanical properties - Google Patents
Feldspar nano ceramic particle abrasive toothpaste containing simulated enamel mechanical properties Download PDFInfo
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- CN116035925A CN116035925A CN202310023847.0A CN202310023847A CN116035925A CN 116035925 A CN116035925 A CN 116035925A CN 202310023847 A CN202310023847 A CN 202310023847A CN 116035925 A CN116035925 A CN 116035925A
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- toothpaste
- abrasive
- nano ceramic
- feldspar
- vitamin
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- 239000002245 particle Substances 0.000 title claims abstract description 51
- 239000000606 toothpaste Substances 0.000 title claims abstract description 48
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 44
- 239000000919 ceramic Substances 0.000 title claims abstract description 36
- 239000010433 feldspar Substances 0.000 title claims abstract description 26
- 210000003298 dental enamel Anatomy 0.000 title abstract description 23
- 229940088594 vitamin Drugs 0.000 claims abstract description 19
- 229930003231 vitamin Natural products 0.000 claims abstract description 19
- 235000013343 vitamin Nutrition 0.000 claims abstract description 19
- 239000011782 vitamin Substances 0.000 claims abstract description 19
- 239000000872 buffer Substances 0.000 claims abstract description 17
- 239000004088 foaming agent Substances 0.000 claims abstract description 17
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 17
- 239000003906 humectant Substances 0.000 claims abstract description 17
- 239000003755 preservative agent Substances 0.000 claims abstract description 17
- 230000002335 preservative effect Effects 0.000 claims abstract description 17
- 239000003765 sweetening agent Substances 0.000 claims abstract description 17
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 13
- -1 compound vitamin Chemical class 0.000 claims abstract description 13
- 239000008367 deionised water Substances 0.000 claims abstract description 12
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000000853 adhesive Substances 0.000 claims abstract description 10
- 230000001070 adhesive effect Effects 0.000 claims abstract description 10
- 230000003285 pharmacodynamic effect Effects 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims description 30
- 238000002156 mixing Methods 0.000 claims description 24
- 230000032683 aging Effects 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 12
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 10
- 239000006185 dispersion Substances 0.000 claims description 10
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 10
- 239000006072 paste Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 8
- 238000000227 grinding Methods 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 239000003292 glue Substances 0.000 claims description 6
- 230000008961 swelling Effects 0.000 claims description 6
- 238000009849 vacuum degassing Methods 0.000 claims description 6
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical group OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 5
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 5
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 5
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 5
- 229930003537 Vitamin B3 Natural products 0.000 claims description 5
- 229930003268 Vitamin C Natural products 0.000 claims description 5
- 229930003427 Vitamin E Natural products 0.000 claims description 5
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 5
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 5
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims description 5
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 229960003512 nicotinic acid Drugs 0.000 claims description 5
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 5
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 5
- 229940085605 saccharin sodium Drugs 0.000 claims description 5
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical group [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 5
- 235000010234 sodium benzoate Nutrition 0.000 claims description 5
- 239000004299 sodium benzoate Substances 0.000 claims description 5
- 239000000600 sorbitol Substances 0.000 claims description 5
- 235000019160 vitamin B3 Nutrition 0.000 claims description 5
- 239000011708 vitamin B3 Substances 0.000 claims description 5
- 235000019158 vitamin B6 Nutrition 0.000 claims description 5
- 239000011726 vitamin B6 Substances 0.000 claims description 5
- 235000019154 vitamin C Nutrition 0.000 claims description 5
- 239000011718 vitamin C Substances 0.000 claims description 5
- 235000019165 vitamin E Nutrition 0.000 claims description 5
- 239000011709 vitamin E Substances 0.000 claims description 5
- 229940046009 vitamin E Drugs 0.000 claims description 5
- 229940011671 vitamin b6 Drugs 0.000 claims description 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical group [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 3
- RPZANUYHRMRTTE-UHFFFAOYSA-N 2,3,4-trimethoxy-6-(methoxymethyl)-5-[3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane;1-[[3,4,5-tris(2-hydroxybutoxy)-6-[4,5,6-tris(2-hydroxybutoxy)-2-(2-hydroxybutoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]butan-2-ol Chemical compound COC1C(OC)C(OC)C(COC)OC1OC1C(OC)C(OC)C(OC)OC1COC.CCC(O)COC1C(OCC(O)CC)C(OCC(O)CC)C(COCC(O)CC)OC1OC1C(OCC(O)CC)C(OCC(O)CC)C(OCC(O)CC)OC1COCC(O)CC RPZANUYHRMRTTE-UHFFFAOYSA-N 0.000 claims description 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- YFNONBGXNFCTMM-UHFFFAOYSA-N butoxybenzene Chemical compound CCCCOC1=CC=CC=C1 YFNONBGXNFCTMM-UHFFFAOYSA-N 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 239000008363 phosphate buffer Substances 0.000 claims description 2
- 235000010241 potassium sorbate Nutrition 0.000 claims description 2
- 239000004302 potassium sorbate Substances 0.000 claims description 2
- 229940069338 potassium sorbate Drugs 0.000 claims description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- 239000004575 stone Substances 0.000 claims 8
- 239000004475 Arginine Substances 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 230000000857 drug effect Effects 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 238000005299 abrasion Methods 0.000 abstract description 12
- 238000004140 cleaning Methods 0.000 abstract description 9
- 238000002360 preparation method Methods 0.000 abstract description 7
- 239000011230 binding agent Substances 0.000 description 7
- 210000004268 dentin Anatomy 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 6
- 239000003082 abrasive agent Substances 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000007872 degassing Methods 0.000 description 4
- 230000035882 stress Effects 0.000 description 4
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical group [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 3
- 229910010293 ceramic material Inorganic materials 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000002105 nanoparticle Substances 0.000 description 2
- 238000005498 polishing Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 238000005245 sintering Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 206010006514 bruxism Diseases 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000000254 damaging effect Effects 0.000 description 1
- 239000010794 food waste Substances 0.000 description 1
- 230000020169 heat generation Effects 0.000 description 1
- 238000011086 high cleaning Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Birds (AREA)
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- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of toothpaste preparation, and particularly relates to feldspar nano ceramic particle abrasive toothpaste containing simulated enamel mechanical properties. The toothpaste comprises the following components in percentage by weight: 10-60 wt% of feldspar nano ceramic particle abrasive, 1-3 wt% of pharmacodynamic agent, 30-40 wt% of humectant, 0.4-1.0 wt% of adhesive, 1.5-2.5 wt% of foaming agent, 0.1-2.0 wt% of preservative, 0.1-0.5 wt% of sweetener, 1.0-3.0 wt% of acid-base buffer, 0.01-0.05 of compound vitamin, and the balance of deionized water, wherein the sum of the total mass percentages is 100%. The toothpaste not only can be matched with the mechanical property of the tooth enamel and ensure moderate friction force to maintain the cleaning force on dirt, but also can lead the tooth surface to be uniformly stressed and has small abrasion on the tooth enamel.
Description
Technical Field
The invention belongs to the technical field of toothpaste preparation, and particularly relates to feldspar nano ceramic particle abrasive toothpaste containing simulated enamel mechanical properties.
Background
Toothpaste is an important component of daily oral care, and one of the main ways of performing cleaning is to remove plaque, pigments and food residues adhered to the tooth surface by friction. Wherein, the abrasive is an important component playing a role in friction, can roll in the friction interface between the toothbrush and the tooth surface to generate three-body abrasion, and the generated friction force can influence the cleaning effect on dirt and the abrasiveness on teeth. Therefore, friction cannot be reduced or increased uniformly, and uniform dispersion of friction is important while ensuring moderate friction. The hardness and particle size of the abrasive directly affect the degree of friction and stress dispersion at the friction interface between the toothbrush and the face. The hardness of the abrasive material needs to be matched with the hardness of the enamel to generate moderate friction force; the larger the granularity of the abrasive is, the smaller the specific surface area is, the more difficult the abrasive is to uniformly disperse on the friction interface than the small particles, so the stress concentration is easier to form, the abrasive can not act as grinding and polishing on the tooth surface like the small particles, the tooth surface is easier to be rough after tooth brushing, and bacteria and the colonization of the biological film are easy to be introduced.
The main abrasive materials in the optional toothpaste ingredients in the market at present are silicon dioxide, calcium carbonate and other particles with larger hardness and micron-sized particle size, and the abrasive materials can play a role in cleaning tooth surfaces, but have larger abrasion on tooth enamel and are easy to increase the roughness of the tooth surfaces.
The toothpaste prepared in the chinese patent application CN109264728A, although achieving the effects of low abrasion and high cleaning, relies on the evaluation method of RDA, i.e. dentin abrasion rate, matching dentin, whereas most of the tooth surfaces of normal people are enamel, only the tooth surfaces of a small number of old people or patients with serious bruxism are basically dentin. The evaluation criteria on which dentin abrasion Rate (RDA) and enamel abrasion Rate (REA) are based are referred to in ISO 11069. However, the prior patent does not relate to the evaluation of the enamel wear rate of REA.
Disclosure of Invention
The invention aims at solving the problems existing in the prior art and provides toothpaste containing feldspar nano ceramic particle abrasive. The toothpaste not only can be matched with the mechanical property of the tooth enamel and ensure moderate friction force to maintain the cleaning force on dirt, but also can lead the tooth surface to be uniformly stressed and has small abrasion on the tooth enamel.
It is another object of the present invention to provide a method for preparing the toothpaste described above. The preparation method is simple and easy to implement and has strong operability.
In order to achieve the above object, the present invention has the following specific technical scheme:
a toothpaste containing feldspar nano ceramic particle abrasive, which comprises the following components in percentage:
10-60 wt% of feldspar nano ceramic particle abrasive, 1-3 wt% of pharmacodynamic agent, 30-40 wt% of humectant, 0.4-1.0 wt% of adhesive, 1.5-2.5 wt% of foaming agent, 0.1-2.0 wt% of preservative, 0.1-0.5 wt% of sweetener, 1.0-3.0 wt% of acid-base buffer, 0.01-0.05 of compound vitamin, and the balance of deionized water, wherein the sum of the total mass percentages is 100%.
Further, the feldspar nano ceramic particle abrasive is used as a friction agent of toothpaste in the application, and the particle size is 32-54 nm. The mechanical properties of the feldspar nano ceramic particles with the particle size comprise the elastic modulus and the hardness which are similar to those of tooth enamel, and compared with the traditional feldspar base ceramic material with the micron-sized particle size, the feldspar nano ceramic particles with the particle size have the advantages of large specific surface area, high reactivity in the sintering process, fewer pores formed after sintering, good internal binding force and reduced brittleness. In the process of reciprocating friction with the tooth enamel, the particles which are rubbed and shed by the feldspar nano ceramic particles are nano abrasive dust, can be uniformly distributed on the surface of the tooth enamel, has the advantages of local stress dispersion, less heat generation and low and uniform abrasion loss, and can play a role in approximate polishing of the tooth enamel.
As a preferred implementation method in the application, the humectant is any one or a mixture of a plurality of sorbitol, xylitol, glycerol, propylene glycol and polyethanol.
As a preferred implementation method in the application, the binder is any one or a mixture of a plurality of hydroxyethyl cellulose, hydroxybutyl methyl cellulose and hydroxymethyl cellulose.
As a preferred embodiment of the present application, the preservative is sodium benzoate, butyl oxybenzene or potassium sorbate.
As a preferred embodiment of the present application, the acid-base buffer is phosphate buffer (typically pH 5.7-8.0,0.2M); the foaming agent is sodium bicarbonate; the sweetener is saccharin sodium.
As a preferred implementation method in the application, the compound vitamin is selected from any one or a mixture of several of vitamin B3, vitamin B6, vitamin C and vitamin E.
Preferably, the preparation method of the toothpaste containing the feldspar nano ceramic particle abrasive comprises the following steps:
weighing the raw materials according to a proportion, and uniformly mixing the adhesive and the humectant together to obtain a pre-dispersion liquid; dissolving sweetener and acid-base buffer in deionized water, and fully stirring and uniformly mixing to obtain pre-dissolving solution; mixing and swelling the pre-dissolved liquid and the pre-dispersed liquid to form homogeneous glue, and ageing to obtain ageing liquid; finally, mixing the aging liquid with the friction agent, the foaming agent, the preservative and the compound vitamin, stirring, grinding and vacuum degassing to obtain the paste component of the toothpaste.
Preferably, the toothpaste is prepared by the following steps:
firstly, uniformly mixing an adhesive and a humectant together to obtain a pre-dispersion liquid; dissolving sweetener and acid-base buffer in deionized water, fully stirring and uniformly mixing until the pH value is 8.5, and controlling the reaction temperature to 80 ℃ to obtain pre-dissolved solution; mixing and swelling the pre-dissolved liquid and the pre-dispersed liquid to form homogeneous glue, and aging for 10 minutes at 65-100 ℃ to obtain aged liquid; finally, mixing, stirring and grinding the aging liquid, the friction agent, the foaming agent, the preservative and the compound vitamin, and carrying out vacuum degassing under the condition of the vacuum degree of-0.09 MPa for 20-40 min, and standing for 24-48 h after degassing to obtain the paste component of the toothpaste.
In the application, the feldspar-based ceramic material is adopted, the hardness and the elastic modulus of the feldspar-based ceramic material are matched with those of tooth enamel, the feldspar-based ceramic abrasive material with a proper particle size range is selected, the frictional wear performance of natural teeth is matched, the wear can be reduced to a certain extent, and the tooth tissue is protected.
Compared with the prior art, the invention has the following positive effects:
the abrasive of the toothpaste is an abrasive mainly comprising feldspar nano ceramic particles. Compared with the traditional hard or soft particles, the feldspar nano ceramic particles are matched with the mechanical properties of the tooth enamel, so that not only is the effective friction force required by cleaning dirt of the toothbrush ensured, but also uniform nano particle abrasive dust can be formed at the friction interface, stress dispersion is formed, and excessive abrasion of the tooth enamel is prevented.
Drawings
FIG. 1 (A) shows the surface morphology of a feldspathic nanoceramic paste and (B) shows the measurement of the nanoparticle size in the paste.
Detailed Description
The present invention will be described in further detail with reference to the following specific embodiments in order to make the objects, technical solutions and advantages of the present invention more apparent, but it should not be construed that the scope of the above subject matter of the present invention is limited to only the following examples. Various substitutions and alterations are made by those skilled in the art without departing from the spirit and scope of the invention.
In the present specification,% unless otherwise specified, means wt%; the raw materials used, unless specified, are all commercial products.
The feldspathic nanoceramic particles used in the examples below were 32-54 a nm a particle size and were commercially available from, for example, editz (Qin Royal island) technology Co., ltd (website: https:// www.aidite.com/zh/homePage).
Example 1:
the toothpaste containing feldspar nano ceramic particle abrasive consists of the following components in percentage by mass: 20 The abrasive comprises, by weight, feldspathic nano ceramic particles (1 wt% can be regarded as 1 g), 30% wt% humectant, 1.0% wt% binder, 2% wt% foaming agent, 1% wt% preservative, 0.5% wt% sweetener, 3.0% wt% acid-base buffer, 0.05% wt% composite vitamin, and the balance deionized water, wherein the total mass percentage is 100%.
Wherein, the paste containing feldspathic nano ceramic particles was observed by a field emission scanning electron microscope, and the particle size of the feldspathic nano ceramic particles was found to be about 40 μm (see FIG. 1).
The humectant in the component is sorbitol, the binder in the component is hydroxyethyl cellulose and hydroxymethyl cellulose, the foaming agent in the component is sodium bicarbonate, the preservative in the component is sodium benzoate, the sweetener in the component is saccharin sodium, the acid-base buffer in the component is phosphoric acid buffer solution, and the compound vitamins in the component comprise vitamin B3, vitamin B6, vitamin C and vitamin E (the content of each vitamin in the compound vitamins is shown in table 1).
The preparation method of the toothpaste comprises the following steps:
firstly, uniformly mixing an adhesive and a humectant together to obtain a pre-dispersion liquid; dissolving sweetener and acid-base buffer in deionized water, stirring thoroughly, mixing to pH 8.5, and controlling the reaction temperature to 80deg.C to obtain pre-dissolved solution; mixing and swelling the pre-dissolved liquid and the pre-dispersed liquid to form homogeneous glue, and aging for 10 minutes at 75 ℃ to obtain aged liquid; finally, mixing, stirring and grinding the aging liquid with the friction agent, the foaming agent, the preservative and the compound vitamin, and carrying out vacuum degassing under the condition of vacuum degree of-0.09 MPa for 30min, and standing for 30h after degassing to finally obtain the paste component of the toothpaste.
Example 2:
the toothpaste containing feldspar nano ceramic particle abrasive consists of the following components in percentage by mass: 40 The abrasive comprises, by weight, feldspathic nano ceramic particle abrasive, 30 wt% humectant, 1.0 wt% binder, 2 wt% foaming agent, 1wt% preservative, 0.5 wt% sweetener, 3.0 wt% acid-base buffer, 0.05 wt% compound vitamin, and the balance deionized water, wherein the sum of the total mass percentages is 100%.
The humectant in the component is sorbitol, the binder in the component is hydroxyethyl cellulose and hydroxymethyl cellulose, the foaming agent in the component is sodium bicarbonate, the preservative in the component is sodium benzoate, the sweetener in the component is saccharin sodium, the acid-base buffer in the component is phosphoric acid buffer solution, and the compound vitamins in the component comprise vitamin B3, vitamin B6, vitamin C and vitamin E.
The preparation method of the toothpaste comprises the following steps:
uniformly mixing the adhesive and the humectant together to obtain a pre-dispersion liquid; dissolving sweetener and acid-base buffer in deionized water, and fully stirring and uniformly mixing to obtain pre-dissolving solution; mixing and swelling the pre-dissolved liquid and the pre-dispersed liquid to form homogeneous glue, and aging for 10 minutes at the temperature of 85 ℃ to obtain aged liquid; finally, mixing the aging liquid with the friction agent, the foaming agent, the preservative and the compound vitamin, stirring, grinding, and carrying out vacuum degassing under the condition of the vacuum degree of-0.09 MPa for 35min, standing for 40h after degassing, thus obtaining the paste component of the toothpaste.
Example 3:
the toothpaste containing feldspar nano ceramic particle abrasive consists of the following components in percentage by mass: 60 The abrasive comprises, by weight, feldspathic nano ceramic particle abrasive, 30 wt% humectant, 1.0 wt% binder, 2 wt% foaming agent, 1wt% preservative, 0.5 wt% sweetener, 3.0 wt% acid-base buffer, 0.05 wt% compound vitamin, and the balance deionized water, wherein the sum of the total mass percentages is 100%.
The humectant in the component is sorbitol, the binder in the component is hydroxyethyl cellulose and hydroxymethyl cellulose, the foaming agent in the component is sodium bicarbonate, the preservative in the component is sodium benzoate, the sweetener in the component is saccharin sodium, the acid-base buffer in the component is phosphoric acid buffer solution, and the compound vitamins in the component comprise vitamin B3, vitamin B6, vitamin C and vitamin E.
The preparation method of the toothpaste comprises the following steps:
uniformly mixing the adhesive and the humectant together to obtain a pre-dispersion liquid; dissolving sweetener and acid-base buffer in deionized water, and fully stirring and uniformly mixing to obtain pre-dissolving solution; mixing and swelling the pre-dissolved liquid and the pre-dispersed liquid to form homogeneous glue, and aging for 10 minutes at 90 ℃ to obtain aged liquid; finally, mixing the aging liquid with the friction agent, the foaming agent, the preservative and the compound vitamin, stirring, grinding, and carrying out vacuum degassing under the condition of the vacuum degree of-0.09 MPa for 28min, standing for 36h after degassing, thus obtaining the paste component of the toothpaste.
The damaging effects on enamel and dentin of the toothpastes prepared in examples 1,2,3 and comparative examples 1,2,3,4 were according to ISO11609:2017 "dental-dentifrice-requirements, test methods and flags" test results are recorded in table 1. REA represents enamel wear rate, RDA represents dentin wear rate
The toothpastes prepared in examples 1,2,3 and comparative examples 1,2,3,4 were tested for tooth cleaning effect according to the method of evaluating the cleaning rate (PCR) of abrasive films in toothpastes published by the dental association ADA, and the test results are recorded in table 1.
Table 1 toothpaste specific ratios and measured RDA, REA, PCR values:
as can be seen from the above table, examples 1,2,3 of the toothpaste containing the feldspar nano ceramic abrasive material have significantly lower enamel abrasion rate REA and dentin abrasion rate RDA than the conventional toothpastes containing silica of comparative examples 1,2,3,4, and significantly better cleaning force PCR than comparative examples 1,2,3, 4.
The above examples are only preferred embodiments of the present patent, but the scope of protection of the present patent is not limited thereto. It should be noted that, for those skilled in the art, it is possible to make several improvements and modifications according to the technical solution of the present patent and the patent conception thereof without departing from the principle of the present patent, and these improvements and modifications are also considered to be within the protection scope of the present patent.
Claims (10)
1. A toothpaste containing feldspar nano ceramic particle abrasive, which is characterized by comprising the following components in percentage:
10-60 wt% of feldspar nano ceramic particle abrasive, 1-3 wt% of pharmacodynamic agent, 30-40 wt% of humectant, 0.4-1.0 wt% of adhesive, 1.5-2.5 wt% of foaming agent, 0.1-2.0 wt% of preservative, 0.1-0.5 wt% of sweetener, 1.0-3.0 wt% of acid-base buffer, 0.01-0.05 of compound vitamin, and the balance of deionized water, wherein the sum of the total mass percentages is 100%.
2. A toothpaste comprising an abrasive of long stone nano ceramic particles according to claim 1, wherein: the feldspar nano ceramic particle abrasive is a friction agent of toothpaste, and the particle size is 32-54 nm.
3. A toothpaste comprising an abrasive of long stone nano ceramic particles according to claim 1, wherein: the pharmacodynamic agent is arginine.
4. A toothpaste comprising an abrasive of long stone nano ceramic particles according to claim 1, wherein: the humectant is one or more of sorbitol, xylitol, glycerol, propylene glycol and polyethylene glycol.
5. A toothpaste comprising an abrasive of long stone nano ceramic particles according to claim 1, wherein: the adhesive is any one or a mixture of a plurality of hydroxyethyl cellulose, hydroxybutyl methyl cellulose and hydroxymethyl cellulose.
6. A toothpaste comprising an abrasive of long stone nano ceramic particles according to claim 1, wherein: the preservative is sodium benzoate, butyl oxybenzene or potassium sorbate.
7. A toothpaste comprising an abrasive of long stone nano ceramic particles according to claim 1, wherein: the acid-base buffer is phosphate buffer.
8. A toothpaste comprising an abrasive of long stone nano ceramic particles according to claim 1, wherein: the foaming agent is sodium bicarbonate; the sweetener is saccharin sodium.
9. A toothpaste comprising an abrasive of long stone nano ceramic particles according to claim 1, wherein: the compound vitamin is selected from any one or a mixture of a plurality of vitamin B3, vitamin B6, vitamin C and vitamin E.
10. A method for preparing a toothpaste comprising feldspathic nanoceramic particle abrasive according to any one of claims 1 to 9, comprising the steps of:
weighing the raw materials according to a proportion, and uniformly mixing the adhesive and the humectant together to obtain a pre-dispersion liquid; dissolving sweetener and acid-base buffer in deionized water, and fully stirring and uniformly mixing to obtain pre-dissolving solution; mixing and swelling the pre-dissolved liquid and the pre-dispersed liquid to form homogeneous glue, and ageing to obtain ageing liquid; finally mixing the aging liquid with the friction agent, the drug effect agent, the foaming agent, the preservative and the compound vitamin, stirring, grinding and vacuum degassing to obtain the paste component of the toothpaste.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1256123A (en) * | 1998-12-09 | 2000-06-14 | 孟祥才 | Hydroxyl apatite toothpaste with dental-filling function |
| EP1449815A2 (en) * | 2003-02-21 | 2004-08-25 | Firma Ivoclar Vivadent AG | Bioactive rhenanite glass-ceramics |
| CN109745235A (en) * | 2019-03-20 | 2019-05-14 | 北京周整无为健康管理有限责任公司 | A kind of toothpaste and application thereof based on labradorite |
| CN113599303A (en) * | 2021-03-05 | 2021-11-05 | 无限极（中国）有限公司 | Oral care composition and preparation method and application thereof |
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2023
- 2023-01-09 CN CN202310023847.0A patent/CN116035925A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1256123A (en) * | 1998-12-09 | 2000-06-14 | 孟祥才 | Hydroxyl apatite toothpaste with dental-filling function |
| EP1449815A2 (en) * | 2003-02-21 | 2004-08-25 | Firma Ivoclar Vivadent AG | Bioactive rhenanite glass-ceramics |
| CN109745235A (en) * | 2019-03-20 | 2019-05-14 | 北京周整无为健康管理有限责任公司 | A kind of toothpaste and application thereof based on labradorite |
| CN113599303A (en) * | 2021-03-05 | 2021-11-05 | 无限极（中国）有限公司 | Oral care composition and preparation method and application thereof |
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| Title |
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| YUSEN SHUI: "The mechanical properties, tribological behaviors and color stability of a feldspar nanoceramics strengthening extrinsic stain for high-translucent zirconia", JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, vol. 140, 3 February 2023 (2023-02-03), pages 1 - 10, XP087285196, DOI: 10.1016/j.jmbbm.2023.105698 * |
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