CN116026735A

CN116026735A - Blood sedimentation detection system and blood sedimentation detection method

Info

Publication number: CN116026735A
Application number: CN202111246923.1A
Authority: CN
Inventors: 张朋; 冯祥; 寻文鹏
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2021-10-26
Filing date: 2021-10-26
Publication date: 2023-04-28

Abstract

The invention provides a blood sedimentation detection system and a blood sedimentation detection method, wherein the blood sedimentation detection system comprises a sampling and distributing component, a blood sedimentation detection component, a liquid path supporting component and a processor, the blood sedimentation detection component comprises a detection pipeline and a blood sedimentation sensor, and the blood sedimentation sensor is arranged corresponding to the detection pipeline; the liquid path support component is used for providing liquid path support for the sampling and distributing component and the blood sedimentation detection component; the sample distribution assembly includes a sample distribution device and a sampling device for collecting a blood sample. The processor is configured to detect dynamic flow information of the blood segment in the detection pipeline by using the blood sedimentation sensor, wherein the flow information at least comprises position information and/or flow velocity information of the blood segment; based on the dynamic flow information of the blood segments, the liquid path support component is regulated to ensure that the blood segments are stopped at the same time, so that the positions of the corresponding measuring points of each blood segment are basically consistent, and the problems of different measuring points of the blood segments caused by the blood segments with different viscosities and the difference of measurement results caused by measuring point deviation are solved.

Description

Blood sedimentation detection system and blood sedimentation detection method

Technical Field

The disclosure relates to the technical field of medical equipment, in particular to a blood sedimentation detection system and a blood sedimentation detection method.

Background

Aggregation method blood sedimentation measurement by measuring the first stage of the formation of a blood sedimentation, the measurement process of the method for indirectly calculating the blood sedimentation value requires that the red blood cells are first disaggregated and dispersed, and the disaggregated blood sample is measured immediately after sudden stop in the pipeline. The emergency stop is a necessary step for measuring blood sedimentation based on the aggregation method, but for the condition that pressure-resistant deformation of a pipeline is large or bubbles are mixed in the pipeline due to overlong pipeline, if samples with different viscosities are in emergency stop after a certain time, larger position deviation can occur, so that different measuring points on blood segments are aimed at when blood sedimentation measurement is carried out on different blood segments by the aggregation method, and finally, the problem of inaccurate detection results due to the measuring point deviation occurs.

Disclosure of Invention

Aiming at the technical problems in the prior art, the disclosure provides a blood sedimentation detection system and a blood sedimentation detection method, wherein the blood sedimentation detection system can enable the positions of measuring points corresponding to each blood segment to be basically consistent, and the problems caused by different blood segment measuring points due to blood segments with different viscosities are solved.

In a first aspect, an embodiment of the present disclosure provides a blood sedimentation detection system, including a sampling and dispensing assembly, a blood sedimentation detection assembly, and a liquid path support assembly, where the blood sedimentation detection assembly includes a detection pipeline and a blood sedimentation sensor, and the blood sedimentation sensor is disposed corresponding to the detection pipeline; the liquid path support component is used for providing liquid path support for the sampling and distributing component and the blood sedimentation detection component; the sampling and distributing assembly comprises a sample distributing device and a sampling device, wherein the sample distributing device is at least used for distributing the collected blood samples to different blood sedimentation detection assemblies; the blood sedimentation detection system further includes: a processor configured to detect dynamic flow information of a blood segment within the detection line using the blood sedimentation sensor, the flow information including at least position information and/or flow rate information of the blood segment; the fluid circuit support assembly adjusts a stop time for stopping the blood segment based on dynamic flow information of the blood segment.

In a second aspect, embodiments of the present disclosure further provide a blood sedimentation detection system, including a sampling and dispensing assembly, a blood sedimentation detection assembly, and a fluid path support assembly, where the blood sedimentation detection assembly includes a detection pipeline, a blood sedimentation sensor, and an additional sensor, where the additional sensor and the blood sedimentation sensor are both disposed corresponding to the detection pipeline, and where the additional sensor is located upstream of the blood sedimentation sensor; the liquid path support component is used for providing liquid path support for the sampling and distributing component and the blood sedimentation detection component; the sampling and distributing assembly comprises a sample distributing device and a sampling device, wherein the sample distributing device is at least used for distributing the collected blood samples to different blood sedimentation detection assemblies; the blood sedimentation detection system further includes: a processor configured to detect dynamic flow information of the blood segment within the detection line, the flow information including at least position information and/or flow rate information of the blood segment, using the additional sensor; the fluid circuit support assembly adjusts a stop time for stopping the blood segment based on dynamic flow information of the blood segment.

In a third aspect, an embodiment of the present disclosure further provides a blood sedimentation detection method, which is applied to a blood sedimentation detection system, where the blood sedimentation detection system includes a sampling and distribution component, a blood sedimentation detection component, and a liquid path support component, and the blood sedimentation detection component includes a detection pipeline and a blood sedimentation sensor, and the blood sedimentation sensor is disposed corresponding to the detection pipeline; the liquid path support component is used for providing liquid path support for the sampling and distributing component and the blood sedimentation detection component; the sampling and distributing assembly comprises a sample distributing device and a sampling device, wherein the sample distributing device is at least used for distributing the collected blood samples to different blood sedimentation detection assemblies; the blood sedimentation detection method comprises the following steps: detecting dynamic flow information of the blood segment in the detection pipeline by using the blood sedimentation sensor, wherein the flow information at least comprises position information and/or flow velocity information of the blood segment; the fluid circuit support assembly adjusts a stop time for stopping the blood segment based on dynamic flow information of the blood segment.

In a fourth aspect, an embodiment of the present disclosure further provides a blood sedimentation detection method, applied to a blood sedimentation detection system, where the blood sedimentation detection system includes a sampling and distribution component, a blood sedimentation detection component, and a liquid path support component, the blood sedimentation detection component includes a detection pipeline, a blood sedimentation sensor, and an additional sensor, where the additional sensor and the blood sedimentation sensor are both disposed corresponding to the detection pipeline, and the additional sensor is located upstream of the blood sedimentation sensor; the liquid path support component is used for providing liquid path support for the sampling and distributing component and the blood sedimentation detection component; the sampling and distributing assembly comprises a sample distributing device and a sampling device, wherein the sample distributing device is at least used for distributing the collected blood samples to different blood sedimentation detection assemblies; the blood sedimentation detection method comprises the following steps: detecting dynamic flow information of the blood segment in the detection pipeline by using the additional sensor, wherein the flow information at least comprises position information and/or flow velocity information of the blood segment; the fluid circuit support assembly adjusts a stop time for stopping the blood segment based on dynamic flow information of the blood segment.

Compared with the prior art, the beneficial effects of the embodiment of the disclosure are that: according to the blood sedimentation sensor, dynamic flow information of blood segments in a detection pipeline is detected, and the stop time of stopping the blood segments by the liquid path support assembly is adjusted based on the flow information, so that the positions of the measuring points corresponding to each blood segment are basically consistent, the problems that the measuring points of the blood segments are different due to the blood segments with different viscosities, and the measuring results are different due to the measuring point deviation are solved, namely, the position deviation of the measuring points corresponding to the different blood segments due to the different viscosities is eliminated or reduced.

Drawings

In the drawings, which are not necessarily drawn to scale, like numerals may describe similar components in different views. The same reference numerals with letter suffixes or different letter suffixes may represent different instances of similar components. The accompanying drawings illustrate various embodiments by way of example in general and not by way of limitation, and together with the description and claims serve to explain the disclosed embodiments. Wherever possible, the same reference numbers will be used throughout the drawings to refer to the same or like parts. Such embodiments are illustrative and not intended to be exhaustive or exclusive of the present apparatus or method.

Fig. 1 is a block diagram of a blood sedimentation detection system according to an embodiment of the present disclosure.

Fig. 2 is a graph of signals detected by a blood sedimentation sensor of a blood sedimentation detection system according to an embodiment of the present disclosure.

Fig. 3 is a schematic structural view of a blood sedimentation detection assembly of a blood sedimentation detection system according to an embodiment of the present disclosure.

Fig. 4 is a schematic structural view of a blood sedimentation detection assembly of a blood sedimentation detection system according to another embodiment of the present disclosure.

Fig. 5 is a flow chart of a blood sedimentation detection method according to an embodiment of the present disclosure.

Fig. 6 is a flowchart of a blood sedimentation detection method according to another embodiment of the present disclosure.

The reference numerals in the drawings denote components:

100-blood sedimentation detection system; 1-a sample distribution assembly; 2-blood sedimentation detection assembly; 21-a detection pipeline; 22-blood sedimentation sensor; 3-a liquid path support assembly; 4-a processor; 23-additional sensors.

Detailed Description

Various aspects and features of the disclosure are described herein with reference to the drawings.

It should be understood that various modifications may be made to the embodiments of the invention herein. Therefore, the above description should not be taken as limiting, but merely as exemplification of the embodiments. Other modifications within the scope and spirit of this disclosure will occur to persons of ordinary skill in the art.

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the disclosure and, together with a general description of the disclosure given above and the detailed description of the embodiments given below, serve to explain the principles of the disclosure.

These and other characteristics of the present disclosure will become apparent from the following description of a preferred form of embodiment, given as a non-limiting example, with reference to the accompanying drawings.

It should also be understood that, although the present disclosure has been described with reference to some specific examples, those skilled in the art can certainly realize many other equivalent forms of the present disclosure.

The above and other aspects, features and advantages of the present disclosure will become more apparent in light of the following detailed description when taken in conjunction with the accompanying drawings.

Specific embodiments of the present disclosure will be described hereinafter with reference to the accompanying drawings; however, it is to be understood that the embodiments of the invention are merely examples of the disclosure, which may be practiced in various ways. Well-known and/or repeated functions and constructions are not described in detail to avoid obscuring the disclosure in unnecessary or unnecessary detail. Therefore, specific structural and functional details disclosed herein are not intended to be limiting, but merely as a basis for the claims and as a representative basis for teaching one skilled in the art to variously employ the present disclosure in virtually any appropriately detailed structure.

The specification may use the word "in one embodiment," "in another embodiment," "in yet another embodiment," or "in other embodiments," which may each refer to one or more of the same or different embodiments in accordance with the disclosure.

The embodiment of the disclosure provides a blood sedimentation detection system 100, as shown in fig. 1, the blood sedimentation detection system 100 comprises a sampling and distributing assembly 1, a blood sedimentation detection assembly 2 and a liquid path support assembly 3, the blood sedimentation detection assembly 2 comprises a detection pipeline 21 and a blood sedimentation sensor 22, and the blood sedimentation sensor 22 is arranged corresponding to the detection pipeline 21; the liquid path support component 3 is used for providing liquid path support for the sampling and distributing component 1 and the blood sedimentation detection component 2; the sample distribution assembly 1 comprises a sample dividing device for at least distributing the collected blood sample to different blood sedimentation detection assemblies 2, and a sampling device for collecting the blood sample. The blood sedimentation detection system 100 may further include a protein detection module or other detection modules for detecting a specific protein, which is not particularly limited herein, and other detection modules may be adaptively added according to actual detection requirements.

Further, the above-described sample distribution assembly 1 is used for collecting a blood sample from a sample container containing the blood sample and distributing the blood sample to the blood sedimentation detection assembly 2. The sampling device may comprise a sampling needle and a power device for driving the sampling needle to collect a blood sample, wherein the power device is provided with a sample suction pipeline connected with the liquid path support assembly 3, and the power device can be a pump, a syringe or other pressure sources capable of providing power, such as a positive pressure source and a negative pressure source. The sample separation device is used for distributing the collected blood sample to the blood sedimentation detection assembly 2 and other detection modules.

Further, the detection line 21 of the blood sedimentation detection assembly 2 is used to provide a detection site for a blood sample. The blood sedimentation sensor 22 may include an optical detection module to irradiate the blood sample in the detection line 21 with light, thereby determining the erythrocyte sedimentation rate of the blood sample according to the absorption or scattering degree of the blood sample in the detection line 21. The blood sedimentation sensor 22 may further include a heater and a temperature sensor, and temperature control of the detection line 21 is achieved by the heater and the temperature sensor.

Further, the liquid path support assembly 3 is configured to provide liquid path support for the sampling and dispensing assembly 1 and the blood sedimentation detection assembly 2, and the liquid path support may include functional support such as fluid driving, reagent filling, liquid path cleaning, and waste liquid draining. For example, the liquid path support assembly 3 may provide cleaning liquid to the sampling and dispensing assembly 1 and the blood sedimentation detection assembly 2, respectively, so as to clean the sampling needle and the detection pipeline 21, respectively, and avoid polluting the blood sample to be detected and causing inaccurate detection results. The liquid path support component 3 can also be connected with the sampling needle through a pipeline so as to keep the pipeline full of diluent, so that the processes of sampling, sample dividing and the like are realized more quickly and reliably.

The blood sedimentation detection system 100 further comprises a processor 4. The processor 4 may be configured to detect dynamic flow information of the blood segment within the detection line 21, including at least position information and/or flow rate information of the blood segment, using the blood sedimentation sensor 22. The processor 4 is further configured to adjust the stop time of the fluid circuit support assembly 3 to stop the blood segment based on the dynamic flow information of the blood segment.

Specifically, the processor 4 may be electrically connected to the sampling and dispensing assembly 1, the blood sedimentation detecting assembly 2, and the fluid path support assembly 3, respectively, to perform information processing and control operations of the respective components.

Specifically, before the blood segment is collected, the fluid path support assembly 3 may suck other substances different from the blood segment into the detection pipeline 21 through the sampling needle, the signal corresponding to the other substances detected by the blood sedimentation sensor 22 is different from the signal corresponding to the detected blood segment, and then suck the other substances into the detection pipeline 21 and then suck the blood segment. The other substances mentioned above are understood to be gaseous and/or liquid substances which are incompatible with the blood segment. In this way, after receiving the signals corresponding to the other substances detected by the blood sedimentation sensor 22 and the signals corresponding to the detected blood segments, the processor 4 can determine the flow information of the blood segments so as to accurately determine the position information and/or the flow velocity information of the blood segments with different viscosities, thereby adjusting the stop time of the blood segments and keeping the position of the measuring point corresponding to each blood segment consistent.

In particular, the above positional information can be understood as the position of the blood segment within the test line 21. The detection pipeline 21 can sequentially suck the other substances and the blood segments, signals corresponding to the other substances are detected through the blood sedimentation sensor 22, signals corresponding to the blood segments are detected through the blood sedimentation sensor 22 after a period of time, and the specific position of the head of the blood segment can be determined.

Specifically, the flow rate information is understood to be the flow rate of the blood segment in the test line 21, which is related to the size specification of the test line 21 and the viscosity of the blood segment. The blood sedimentation sensor 22 may include position information of a blood segment capable of detecting at least two different points, and the flow rate of the blood segment can be determined based on the detected at least two position information, so that the time to reach the detection point designated by the blood sedimentation sensor 22 is determined according to the flow rate, and the stop time of stopping the blood segment by the fluid circuit support assembly 3 is adjusted. The above detection point can be understood as a preset point position corresponding to the blood sedimentation sensor 22 on the detection pipeline 21, and the blood segment stops at the detection point to be detected under the action of the liquid path support component 3, so that the blood sedimentation sensor 22 can detect more accurate results.

Specifically, after the dynamic flow information of the blood segment is determined, it can be determined when the blood segment stops and the measuring point of the blood segment can be corresponding to the detecting point of the blood sedimentation sensor 22, so that the measuring points of different blood segments can all correspond to the detecting point of the blood sedimentation sensor 22 based on the adjusted stopping time, thereby obtaining an accurate measuring result, and avoiding the problem that the detecting result is inaccurate due to larger position deviation caused by the fact that the blood segments with different viscosities are all stopped suddenly after the same time.

According to the blood sedimentation sensor, dynamic flow information of blood segments in the detection pipeline 21 is detected through the blood sedimentation sensor 22, and the stop time of stopping the blood segments by the liquid path support assembly 3 is regulated based on the flow information, so that the positions of the measuring points corresponding to each blood segment are basically consistent, namely, after the dynamic flow information of the blood segments is determined, the blood segments stop flowing when driven by the liquid path support assembly 3 to move to the stop time, so that the measuring points of different blood segments detected by the blood sedimentation sensor 22 are basically consistent, and the problems of different blood segment measuring points caused by the blood segments with different viscosities and the difference of measurement results caused by measuring point deviation are solved, namely, the position deviation of the measuring points corresponding to the different blood segments caused by different viscosities is eliminated or reduced.

In some embodiments, the processor 4 is further configured to:

dynamically acquiring measurement signals of a corresponding portion of the blood segment in which it is located using the blood sedimentation sensor 22;

identifying a mutation in the acquired measurement signal of the corresponding portion of the blood segment;

based on the identified mutation, the position of the blood segment relative to the blood sedimentation sensor 22 when the mutation occurs is determined as position information of the blood segment.

In particular, the abrupt change may be understood as a sudden change in the corresponding signal detected by the blood sedimentation sensor 22 when it detects a different substance. Specifically, referring to fig. 2, the diluent, the isolating air column and the blood segment sequentially flow through the detection points of the blood sedimentation sensor 22, and it can be seen that the signals detected by the blood sedimentation sensor 22 are different for different substances, and the signals detected by the blood sedimentation sensor 22 are abrupt when different substances flow through, so that the flow information of the blood segment can be accurately determined by the signals detected by the blood sedimentation sensor 22. In fig. 2, the diluent and the isolating gas column may be other substances different from the blood segment, and may be different from the signals of the blood segment detected by the blood sedimentation sensor 22, so as to determine the position information of the blood segment through the abrupt signals.

Illustratively, the sampling needle of the sampling dispensing assembly 1 may sequentially draw in one or more substances other than the blood segment prior to drawing in the blood segment, such as only a diluent prior to drawing in the blood segment, or a diluent and a barrier air column prior to drawing in the blood segment, as the application is not specifically limited in this regard, the one or more substances detected by the blood sedimentation sensor 22 and the signal of the blood segment may be different and may be subject to abrupt changes. After the sampling needle sucks the above substances into the detection pipeline 21, the blood segment is sucked again, so that the blood sedimentation sensor 22 feeds back the detected signals to the processor 4 in real time, and the processor 4 can accurately determine the position information of the blood segment when the head of the blood segment flows through the detection point of the blood sedimentation sensor 22 based on the signals detected by the blood sedimentation sensor 22, thereby adjusting the stop time of the blood segment according to the position information.

In some embodiments, the position of the blood segment relative to the blood sedimentation sensor 22 includes the head of the blood segment flowing past the blood sedimentation sensor 22.

Specifically, the processor 4 identifies the mutation in the acquired measurement signal of the corresponding part of the blood segment, so that the position information of the head of the blood segment can be determined, and after the position of the head of the blood segment is determined, the flow of the blood segment is stopped after the blood segment flows for a preset time through the liquid path support assembly 3, and the stop time is the stop time at this time, so that the position of the measuring point corresponding to the blood segment can be ensured to reach the position capable of accurately measuring the result.

In some embodiments, the abrupt change may be a first abrupt change between a corresponding portion of the diluent and a corresponding portion of the isolation gas column in the measurement signal and/or a second abrupt change between a corresponding portion of the blood sample and a corresponding portion of the isolation gas column; or a first abrupt change between the corresponding portion of the diluent and the corresponding portion of the isolation gas column and a second abrupt change between the corresponding portion of the blood sample and the corresponding portion of the isolation gas column in the measurement signal in sequence.

Specifically, the above-mentioned fluid path support assembly 3 may sequentially suck the diluent and the blood segment in the detection pipeline 21 through the sampling needle, sequentially suck the diluent, the isolation air column and the blood segment, or sequentially suck the isolation air column, the diluent and the blood segment, and can enable the blood sedimentation sensor 22 to detect the abrupt change in the signal, which is not particularly limited in this application. The following description will be given taking an example in which the liquid channel support member 3 sequentially sucks the diluent, the isolation air column, and the blood segment into the detection channel 21 through the sampling needle.

With specific reference to fig. 3, the arrow shown in fig. 3 is the flow direction of the substance in the detection pipeline 21, before the sample is sucked, the liquid pipeline support assembly 3 makes part of the sample sucking pipeline be filled with diluent, and part of the sample sucking pipeline close to the sampling needle and the sampling needle are filled with gas, after the sample is sucked, the above-mentioned isolating gas column is formed between the blood segment and the diluent, and the gas forming the isolating gas column can be air or other gas indissoluble in the diluent and the blood sample. The isolating air column can ensure the effect of isolating blood sections and diluent and can also ensure the rapid sample suction and sample separation.

The presently disclosed embodiments also provide another blood sedimentation detection system 100, as shown in fig. 1 and 4, the blood sedimentation detection system 100 includes a sampling and dispensing assembly 1, a blood sedimentation detection assembly 2, and a liquid path support assembly 3, the blood sedimentation detection assembly 2 includes a detection pipe 21, a blood sedimentation sensor 22, and an additional sensor 23, the additional sensor 23 and the blood sedimentation sensor 22 are each disposed corresponding to the detection pipe 21, and the additional sensor 23 is located upstream of the blood sedimentation sensor 22; the liquid path support component 3 is used for providing liquid path support for the sampling and distributing component 1 and the blood sedimentation detection component 2; the sample distribution assembly 1 comprises a sample dividing device for at least distributing the collected blood sample to different blood sedimentation detection assemblies 2, and a sampling device for collecting the blood sample. The blood sedimentation detection system 100 may further include a protein detection module or other detection modules for detecting specific proteins, which are not specifically limited in this application, and other detection modules may be adaptively added according to actual detection requirements.

Further, the blood sedimentation detection system 100 further comprises a processor 4. The processor 4 may be configured to detect dynamic flow information of the blood segment within the detection line 21, the flow information comprising at least position information and/or flow rate information of the blood segment, using the additional sensor 23; based on the dynamic flow information of the blood segment, the fluid circuit support assembly 3 is adjusted to stop the blood segment for a stop time.

Specifically, the additional sensor 23 may be the same sensor as the blood sedimentation sensor 22, or may be a different sensor, that is, the additional sensor 23 may be an optical detection module, an impedance sensor, or other sensor capable of detecting the position information and/or the flow rate information of the bleeding segment, which is not specifically limited in this application.

Specifically, before the blood segment is collected, the liquid path support component 3 may suck other substances different from the blood segment into the detection pipeline 21 through the sampling needle, the signals corresponding to the other substances detected by the blood sedimentation sensor 22 and the additional sensor 23 are different from the signals corresponding to the detected blood segment, and then suck other substances into the detection pipeline 21 and then suck the substances into the blood segment. The other substances mentioned above are understood to be gaseous and/or liquid substances which are incompatible with the blood segment. In this way, after the processor 4 receives the signal corresponding to the other substances detected by the additional sensor 23 and the signal corresponding to the detected blood segment, the flow information of the blood segment can be determined, the processor 4 adjusts the stop time of the blood segment based on the obtained flow information, so that the position of the measuring point corresponding to each blood segment can keep consistent, and the blood sedimentation corresponding to the blood segment is measured by the blood sedimentation sensor 22 after the blood segment stops.

Specifically, the additional sensor 23 may be one, and may be disposed upstream or downstream of the blood sedimentation sensor 22, so as to obtain flow information of the blood segment in the detection line 21, and adjust the stop time of the blood segment. Of course, the number of the additional sensors 23 may be plural, and as shown in fig. 3, two additional sensors 23 may be provided upstream and downstream of the blood sedimentation sensor 22, respectively, or at least two additional sensors 23 may be provided upstream of the blood sedimentation sensor 22, so as to achieve the purpose of obtaining the flow information of the blood segment.

The dynamic flow information of the blood segments in the detection pipeline 21 is detected by the additional sensor 23, and the stop time of stopping the blood segments by the liquid path support assembly 3 is regulated based on the flow information, so that the positions of the measuring points corresponding to each blood segment are basically consistent, namely, after the dynamic flow information of the blood segments is determined, the blood segments stop flowing when driven by the liquid path support assembly 3 to move to the stop time, thus ensuring that the measuring points of different blood segments detected by the blood sedimentation sensor 22 are basically consistent, thereby overcoming the problems of different blood segment measuring points caused by blood segments with different viscosities and the difference of measuring results caused by measuring point deviation, namely eliminating or reducing the position deviation of the measuring points corresponding to different blood segments caused by different viscosities.

In some embodiments, the processor 4 is further configured to: dynamically acquiring measurement signals of a corresponding portion of the blood segment in which it is located, using at least one additional sensor 23 upstream of the measurement point; identifying a mutation in the acquired measurement signal of the corresponding portion of the blood segment; based on the identified mutation, the position of the blood segment relative to the at least one additional sensor 23 when the mutation occurs is determined as position information of the blood segment.

In particular, the abrupt change described above can be understood as a sudden change in the corresponding signal that is detected by the additional sensor 23 when it detects a different substance. The signals detected by the additional sensor 23 are different for different substances, and the signals detected by the additional sensor 23 are mutated when different substances flow through, so that the flow information of the bleeding section can be accurately judged by the signals detected by the additional sensor 23. The different substances may be a diluent and/or a separation gas column, or may be other substances different from the blood segment, and may be different from the signals of the blood segment detected by the additional sensor 23, so as to determine the position information of the blood segment through the abrupt signals.

Illustratively, the sampling needle of the sampling dispensing assembly 1 may sequentially draw in one or more substances other than the blood segment prior to drawing in the blood segment, such as only a diluent prior to drawing in the blood segment, or a diluent and a barrier air column prior to drawing in the blood segment, which is not particularly limited herein, and the one or more substances detected by the additional sensor 23 and the signal of the blood segment may be different and may be subject to abrupt change. After the sampling needle sucks the above-mentioned substances into the detection pipeline 21, the blood segment is sucked again, so that the additional sensor 23 feeds back the detected signal to the processor 4 in real time, and the processor 4 can accurately determine the position information of the blood segment when the head of the blood segment flows through the detection point of the additional sensor 23 based on the signal detected by the additional sensor 23, so that the stopping time of the blood segment is adjusted according to the position information, and an accurate detection result is obtained through the blood sedimentation sensor 22.

In some embodiments, the at least one additional sensor 23 includes a first additional sensor and a second additional sensor. The processor 4 is further configured to: dynamically acquiring a first measurement signal and a second measurement signal of a corresponding portion of a blood segment in which the first and second additional sensors are located, respectively, using the first and second additional sensors; identifying a sudden change in the first measurement signal and the second measurement signal, respectively; determining, based on the identified abrupt change, a time at which the abrupt change occurred, and a first location of the blood segment relative to the first additional sensor and a second location relative to the second additional sensor when the abrupt change occurred; based on the first and second locations and the time at which the mutation occurred, a flow rate of the blood segment is determined to be dynamic flow information of the blood segment along with the first and/or second locations.

Specifically, the first additional sensor and the second additional sensor are sequentially disposed at the upstream of the blood sedimentation sensor 22, and can respectively obtain corresponding measurement signals, and the processor 4 identifies mutation based on the first measurement signal and the second measurement signal, so as to determine mutation time when the flowing blood segment sequentially flows through the first additional sensor and the second additional sensor, and determine flow velocity of the blood segment in the current detection pipeline 21 based on the mutation time, so as to determine flow information of the blood segment, and adjust stop time of the blood segment according to different blood segments, so that positions of measuring points corresponding to each blood segment can keep consistent, and accuracy of results is ensured.

Specifically, the above-mentioned fluid path support assembly 3 may sequentially suck the diluent and the blood in the detection pipeline 21 through the sampling needle, sequentially suck the diluent, the isolation air column and the blood, or sequentially suck the isolation air column, the diluent and the blood, so that the first measurement signal and the second measurement signal can identify the mutation in the signals.

The embodiment of the disclosure also provides a blood sedimentation detection method, as shown in fig. 5, applied to a blood sedimentation detection system 100, wherein the blood sedimentation detection system 100 comprises a sampling and distribution assembly 1, a blood sedimentation detection assembly 2 and a liquid path support assembly 3, the blood sedimentation detection assembly 2 comprises a detection pipeline 21 and a blood sedimentation sensor 22, and the blood sedimentation sensors 22 are arranged corresponding to the detection pipeline 21; the liquid path support component 3 is used for providing liquid path support for the sampling and distributing component 1 and the blood sedimentation detection component 2; the sampling and dispensing assembly 1 comprises a sample dividing device and a sampling device, wherein the sample dividing device is used for at least dividing the collected blood samples to different blood sedimentation detection assemblies 2; the blood sedimentation detection method includes steps S101 to S102.

Step S101: dynamic flow information of the blood segment in the detection line 21 is detected by the blood sedimentation sensor 22, and the flow information includes at least position information and/or flow velocity information of the blood segment.

Step S102: based on the dynamic flow information of the blood segment, the fluid circuit support assembly 3 is adjusted to stop the blood segment for a stop time.

In some embodiments, step S101: the detection of dynamic flow information of the blood segment in the detection line 21 by the blood sedimentation sensor 22 specifically includes:

In some embodiments, the mutation is:

measuring a first abrupt change between a corresponding portion of the diluent and a corresponding portion of the isolation gas column and/or a second abrupt change between a corresponding portion of the blood sample and a corresponding portion of the isolation gas column in the signal; or (b)

A first abrupt change between the corresponding portion of the diluent and the corresponding portion of the isolation gas column and a second abrupt change between the corresponding portion of the blood sample and the corresponding portion of the isolation gas column in the sequential measurement signals.

The embodiment of the disclosure also provides another blood sedimentation detection method, as shown in fig. 6, applied to a blood sedimentation detection system 100, where the blood sedimentation detection system 100 includes a sampling and distribution assembly 1, a blood sedimentation detection assembly 2, and a liquid path support assembly 3, the blood sedimentation detection assembly 2 includes a detection pipeline 21, a blood sedimentation sensor 22, and an additional sensor 23, the additional sensor 23 and the blood sedimentation sensor 22 are both disposed corresponding to the detection pipeline 21, and the additional sensor 23 is located upstream of the blood sedimentation sensor 22; the liquid path support component 3 is used for providing liquid path support for the sampling and distributing component 1 and the blood sedimentation detection component 2; the sampling and dispensing assembly 1 comprises a sample dividing device and a sampling device, wherein the sample dividing device is used for at least dividing the collected blood samples to different blood sedimentation detection assemblies 2; the blood sedimentation detection method includes steps S201 to S202.

Step S201: the dynamic flow information of the blood segment in the detection line 21 is detected by the additional sensor 23, the flow information including at least the position information and/or the flow velocity information of the blood segment.

Step S202: based on the dynamic flow information of the blood segment, the fluid circuit support assembly 3 is adjusted to stop the blood segment for a stop time.

In some embodiments, step S201: the additional sensor 23 is used for detecting dynamic flow information of the blood segment in the detection pipeline 21, and specifically comprises the following steps:

dynamically acquiring measurement signals of a corresponding portion of the blood segment in which it is located, using at least one additional sensor 23 upstream of the measurement point;

based on the identified mutation, the position of the blood segment relative to the at least one additional sensor 23 when the mutation occurs is determined as position information of the blood segment.

In some embodiments, the at least one additional sensor 23 comprises a first additional sensor and a second additional sensor, and detecting dynamic flow information of the blood segment within the test line 21 with the additional sensor 23 further comprises:

dynamically acquiring a first measurement signal and a second measurement signal of a corresponding portion of a blood segment in which the first and second additional sensors are located, respectively, using the first and second additional sensors;

identifying a sudden change in the first measurement signal and the second measurement signal, respectively;

determining, based on the identified abrupt change, a time at which the abrupt change occurred, and a first location of the blood segment relative to the first additional sensor and a second location relative to the second additional sensor when the abrupt change occurred;

based on the first and second locations and the time at which the mutation occurred, a flow rate of the blood segment is determined to be dynamic flow information of the blood segment along with the first and/or second locations.

It should be noted that, among the components of the system of the present application, the components thereof are logically divided according to functions to be implemented, but the present application is not limited thereto, and the components may be re-divided or combined as needed, for example, some components may be combined into a single component, or some components may be further decomposed into more sub-components.

Furthermore, although exemplary embodiments have been described herein, the scope thereof includes any and all embodiments having equivalent elements, modifications, omissions, combinations (e.g., of the various embodiments across), adaptations or alterations as pertains to the present application. Elements in the claims are to be construed broadly based on the language employed in the claims and are not limited to examples described in the present specification or during the practice of the present application, which examples are to be construed as non-exclusive. It is intended, therefore, that the specification and examples be considered as exemplary only, with a true scope and spirit being indicated by the following claims and their full scope of equivalents.

The above description is intended to be illustrative and not restrictive. For example, the above-described examples (or one or more aspects thereof) may be used in combination with each other. For example, other embodiments may be used by those of ordinary skill in the art upon reading the above description. In addition, in the above detailed description, various features may be grouped together to streamline the application. This is not to be interpreted as an intention that the disclosed features not being claimed are essential to any claim. Rather, the subject matter of the present application is capable of less than all of the features of a particular disclosed embodiment. Thus, the following claims are hereby incorporated into the detailed description as examples or embodiments, with each claim standing on its own as a separate embodiment, and it is contemplated that these embodiments may be combined with one another in various combinations or permutations. The scope of the application should be determined with reference to the appended claims, along with the full scope of equivalents to which such claims are entitled.

The above embodiments are only exemplary embodiments of the present application and are not intended to limit the present application, the scope of which is defined by the claims. Various modifications and equivalent arrangements may be made to the present application by those skilled in the art, which modifications and equivalents are also considered to be within the scope of the present application.

Claims

1. The blood sedimentation detection system is characterized by comprising a sampling and distributing assembly, a blood sedimentation detection assembly and a liquid path support assembly, wherein the blood sedimentation detection assembly comprises a detection pipeline and a blood sedimentation sensor, and the blood sedimentation sensor is arranged corresponding to the detection pipeline; the liquid path support component is used for providing liquid path support for the sampling and distributing component and the blood sedimentation detection component; the sampling and distributing assembly comprises a sample distributing device and a sampling device, wherein the sample distributing device is at least used for distributing the collected blood samples to different blood sedimentation detection assemblies; the blood sedimentation detection system further includes:

a processor configured to detect dynamic flow information of a blood segment within the detection line using the blood sedimentation sensor, the flow information including at least position information and/or flow rate information of the blood segment;

the fluid circuit support assembly adjusts a stop time for stopping the blood segment based on dynamic flow information of the blood segment.

2. The blood sedimentation detection system of claim 1, wherein the processor is further configured to:

dynamically acquiring measurement signals of the corresponding part of the blood segment in which the blood sedimentation sensor is positioned by utilizing the blood sedimentation sensor;

based on the identified mutation, a position of the blood segment relative to the blood sedimentation sensor at the time of occurrence of the mutation is determined as position information of the blood segment.

3. The blood sedimentation detection system of claim 2, wherein the mutation is:

4. The blood sedimentation detection system of claim 2, wherein the position of the blood segment relative to the blood sedimentation sensor comprises a head of the blood segment flowing past the blood sedimentation sensor.

5. The blood sedimentation detection system is characterized by comprising a sampling and distributing assembly, a blood sedimentation detection assembly and a liquid path support assembly, wherein the blood sedimentation detection assembly comprises a detection pipeline, a blood sedimentation sensor and an additional sensor, the additional sensor and the blood sedimentation sensor are arranged corresponding to the detection pipeline, and the additional sensor is positioned at the upstream of the blood sedimentation sensor; the liquid path support component is used for providing liquid path support for the sampling and distributing component and the blood sedimentation detection component; the sampling and distributing assembly comprises a sample distributing device and a sampling device, wherein the sample distributing device is at least used for distributing the collected blood samples to different blood sedimentation detection assemblies; the blood sedimentation detection system further includes:

A processor configured to detect dynamic flow information of the blood segment within the detection line, the flow information including at least position information and/or flow rate information of the blood segment, using the additional sensor;

6. The blood sedimentation detection system of claim 5, wherein the processor is further configured to:

dynamically acquiring measurement signals of a corresponding portion of the blood segment in which it is located using at least one additional sensor upstream of the measurement point;

based on the identified mutation, a position of the blood segment relative to the at least one additional sensor at the time the mutation occurred is determined as position information of the blood segment.

7. The blood sedimentation detection system of claim 6, wherein the at least one additional sensor comprises a first additional sensor and a second additional sensor, the processor being further configured to:

dynamically acquiring a first measurement signal and a second measurement signal of a corresponding portion of the blood segment in which the first and second additional sensors are located, respectively, using the first and second additional sensors;

8. The blood sedimentation detection method is characterized by being applied to a blood sedimentation detection system, wherein the blood sedimentation detection system comprises a sampling and distributing component, a blood sedimentation detection component and a liquid path supporting component, the blood sedimentation detection component comprises a detection pipeline and a blood sedimentation sensor, and the blood sedimentation sensor is arranged corresponding to the detection pipeline; the liquid path support component is used for providing liquid path support for the sampling and distributing component and the blood sedimentation detection component; the sampling and distributing assembly comprises a sample distributing device and a sampling device, wherein the sample distributing device is at least used for distributing the collected blood samples to different blood sedimentation detection assemblies; the blood sedimentation detection method comprises the following steps:

Detecting dynamic flow information of the blood segment in the detection pipeline by using the blood sedimentation sensor, wherein the flow information at least comprises position information and/or flow velocity information of the blood segment;

9. The method for detecting blood sedimentation according to claim 8, wherein detecting dynamic flow information of a blood segment in the detection line by using the blood sedimentation sensor comprises:

10. The method of claim 9, wherein the mutation is:

11. The method of claim 9, wherein the position of the blood segment relative to the blood sedimentation sensor comprises a head of the blood segment flowing past the blood sedimentation sensor.

12. The blood sedimentation detection method is characterized by being applied to a blood sedimentation detection system, wherein the blood sedimentation detection system comprises a sampling and distribution component, a blood sedimentation detection component and a liquid path support component, the blood sedimentation detection component comprises a detection pipeline, a blood sedimentation sensor and an additional sensor, the additional sensor and the blood sedimentation sensor are arranged corresponding to the detection pipeline, and the additional sensor is positioned upstream of the blood sedimentation sensor; the liquid path support component is used for providing liquid path support for the sampling and distributing component and the blood sedimentation detection component; the sampling and distributing assembly comprises a sample distributing device and a sampling device, wherein the sample distributing device is at least used for distributing the collected blood samples to different blood sedimentation detection assemblies; the blood sedimentation detection method comprises the following steps:

Detecting dynamic flow information of the blood segment in the detection pipeline by using the additional sensor, wherein the flow information at least comprises position information and/or flow velocity information of the blood segment;

13. The method of claim 12, wherein detecting dynamic flow information of a blood segment in the test line with the additional sensor, specifically comprises:

14. The method of blood sedimentation detection of claim 13, wherein the at least one additional sensor comprises a first additional sensor and a second additional sensor, the detecting dynamic flow information of a blood segment within the detection line with the additional sensor further comprising: