CN116022466A

CN116022466A - Isolation packaging structure and forming process thereof

Info

Publication number: CN116022466A
Application number: CN202310131503.1A
Authority: CN
Inventors: 李和伟
Original assignee: Changzhou Fuqian Biotechnology Co ltd
Current assignee: Changzhou Fuqian Biotechnology Co ltd
Priority date: 2023-02-17
Filing date: 2023-02-17
Publication date: 2023-04-28
Also published as: WO2024168960A1

Abstract

The invention relates to the technical field of efficacy essence packaging supplies, in particular to an isolation packaging structure and a forming process thereof, which are improved on the basis of the existing BFS technology, can automatically complete the whole technological processes of blowing, filling, throwing and sealing, and has small occupied area of equipment and low energy consumption in the production process, so that the comprehensive production cost of the BFS aseptic filling process is not higher than that of the traditional aseptic filling process, but the product quality and the comprehensive economic benefit are greatly higher than those of the traditional aseptic filling process.

Description

Isolation packaging structure and forming process thereof

Technical Field

The invention relates to the technical field of efficacy essence packaging supplies, in particular to an isolation packaging structure.

Background

With the increasing intensive research into the use of efficacy essences, more and more attention is paid to the efficacy essences.

For example, in the case of a dry essence preparation, there is no concern about deterioration, oxidation (damp deterioration) of active ingredients due to the growth of microorganisms caused by an aqueous environment, and thus there is no need to add preservatives, antibacterial agents, etc. thereto, and these adjuvants also cause side effects to the human body or skin. Only at the time of use, the dry essence preparation needs to be mixed and dissolved by adding water.

On the other hand, when some functional components are mixed and stored, the performance of the functional components is unstable, so that the performance of the active functions of the functional components is affected, for example, substances with stronger antioxidant activity, polysaccharide and proteins are mixed, so that the activity is reduced; the mixing of various more acidic substances with protein substances also results in reduced activity; the mixing of proteins and "carbonyl compounds", proteins and carbohydrates, results in non-enzymatic glycosylation reactions, which all lead to reduced efficacy of the ingredients. However, when these functional components are mixed (used together), the effect is often better.

Therefore, the functional components of the essence and the auxiliary materials are suitable for being stored separately and mixed. There are also packages in the prior art that store essence separately, for example, the patent of the invention "EP15173946.3" discloses a container that can store two flowable substances separately, in particular, a container assembly having a first container that operably holds a second container. The first container is configured to hold a first flowable substance and the second container is configured to hold a second flowable substance. The second container is rupturable, preferably by manipulation through the first container, wherein the second flowable substance is mixable with the first flowable substance to form a mixture.

However, the isolation packaging structure in the prior art adopts the traditional aseptic filling process, the efficiency is low, the quality of essence cannot be guaranteed, specifically, 1, in the traditional aseptic filling process, because the equipment cannot really realize CIP/SIP, especially the key components of the equipment need to be assembled and debugged manually before use, the efficiency is low, and the equipment and the aseptic environment can be polluted. 2. The container and the components are purchased externally, are cleaned and sterilized respectively and then are combined together, the process is complicated, the labor intensity is high, the risk of pollution exists in each link, and the requirement of sterility assurance in the whole process cannot be met. 3. The high-temperature sterilization process can change the active ingredients of the essence and generate new substances, and some products cannot realize high-temperature sterilization due to the limitations of raw materials and processes, so that the requirements of the aseptic medicine production process are not met. 4. The equipment components and the conveying pipelines after sterilization and filtration can not realize CIP/SIP, the components of the equipment before filling are required to be assembled and debugged manually, the personnel operation is required in a filling area, the uncontrollable factors are many, the waste is not degradable, the environment is polluted, and the requirements of user safety, operator safety and environment safety can not be met.

Disclosure of Invention

The invention provides an isolation packaging structure and a forming process thereof, which aim to solve the problems that the forming process of a dual-cavity isolation packaging structure in the prior art is low in efficiency and difficult to control the quality.

The technical scheme adopted for solving the technical problems is as follows:

in one aspect of the present invention, there is provided a process for forming an insulation package structure, comprising the steps of:

a first receiving body is provided which is configured to receive the first receiving body,

filling a first preparation in the first accommodating body, and sealing the first accommodating body;

extruding the formed blank by BFS technology;

blowing a second accommodating body according to the shape of the die by using BFS technology and filling a second preparation;

the first accommodating body is put into the second accommodating body;

packaging the second accommodating body by using BFS technology to form a complete package;

after sealing, the mould is opened to send out the package.

According to one embodiment of the invention, a coating is produced on the surface of the first receiving body, said coating being located on the inner and/or outer surface of the first receiving body.

According to one embodiment of the invention, a coating is made on the surface of the first container, the coating is made by adopting a plasma coating process, and the material of the thin film organic coating of the plasma coating is polyethylene, polystyrene, siloxane, fluorine-containing polymer, amination, hydroxyethyl methacrylate, silane or vinyl.

According to one embodiment of the invention, a coating is made on the surface of the first containing body, and the coating process is a SideLe Actis coating, a DLC coating or a Parylene coating.

According to one embodiment of the invention, the second formulation is filled and then the first container is put in by a blow-and-fill mechanism comprising a blow-and-fill needle which is connected to the flow pump via a first branch channel and to a put-in device via a second branch channel, the end of the blow-and-fill needle being provided with an air pump, the put-in device feeding the first container into the blow-and-fill needle and putting it into the second container by the pressure of the air pump.

According to one embodiment of the invention, the second formulation is filled with a blow-fill mechanism and then the first pod is fed into the second pod with a manipulator.

According to one embodiment of the invention, the first formulation is a solid or a liquid and the second formulation is a liquid.

In another aspect of the present invention, an insulation packaging structure is provided, which is manufactured by adopting the above-mentioned insulation packaging structure forming process, and includes a first accommodating body and a second accommodating body, and two independent accommodating cavities are formed, wherein the first accommodating body is placed in the second accommodating body, and a coating is formed on an inner surface and/or an outer surface of the first accommodating body.

According to one embodiment of the invention, the coating is made of parylene, the thickness of the coating being 0.5 μm-1 μm.

According to one embodiment of the invention, the first containing body has a diameter of 0.5-1cm, a length of 20-30mm and a wall thickness of 1-2mm.

According to one embodiment of the present invention, the second container contains liquid essence therein, and the first container contains lyophilized powder therein.

The beneficial effects are that:

(1) The invention is improved on the basis of the existing BFS technology, can automatically complete the whole technological processes of blowing, filling, casting and sealing and monitoring, has small equipment occupation area and low energy consumption in the production process, so the comprehensive production cost of the BFS aseptic filling process is not higher than that of the traditional aseptic filling process, but the product quality and the comprehensive economic benefit are greatly higher than those of the traditional aseptic filling process.

(2) The CIP/SIP can be automatically completed under the control of a computer program by using the BFS technology, and the method has reliable reproducibility and high efficiency.

(3) Sterile filling can be realized by using BFS technology, high-temperature sterilization is not needed, the product quality is stable, and the method can be suitable for filling various sterile products and producing various sterile containers by only changing different dies.

(4) The quality of the essence packaging product produced by the BFS technology is high.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed in the description of the embodiments will be briefly described below, it being obvious that the drawings in the following description are only some embodiments of the present invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic view of an insulation package structure of the present embodiment;

fig. 2 is a schematic structural view of the first container of the present embodiment;

fig. 3 is a schematic diagram of a rupture structure of the first container of the present embodiment;

fig. 4 is a schematic structural view of the blow-irrigation mechanism of the present embodiment;

fig. 5 is a schematic structural diagram of a vibration feeding device in this embodiment;

fig. 6 is a schematic structural diagram of a deflection yoke assembly according to this embodiment.

Wherein,,

a first accommodating body 1, a first accommodating cavity 11, a first sub-accommodating body 12 and an inclined plane 13;

a second accommodating body 2;

a fracture structure 3, a thinned portion 31, thinned wires 32, a dislocated engagement portion 33, and bonding wires 34;

the blowing and filling mechanism 4, a blowing and filling needle 41, a first branch channel 42, a second branch channel 43, a base 44, a pneumatic push rod 45, an air pump 46 and a feeding channel 47;

the device comprises a vibration feeding device 5, a vibration feeding disc 51, a transfer channel 52, a blowing component 53 and a deflection guiding component 54.

Detailed Description

The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. The following description of at least one exemplary embodiment is merely exemplary in nature and is in no way intended to limit the invention, its application, or uses. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments in accordance with the present application. As used herein, the singular is also intended to include the plural unless the context clearly indicates otherwise, and furthermore, it is to be understood that the terms "comprises" and/or "comprising" when used in this specification are taken to specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof.

The relative arrangement of the components and steps, numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present invention unless it is specifically stated otherwise. Meanwhile, it should be understood that the sizes of the respective parts shown in the drawings are not drawn in actual scale for convenience of description. Techniques, methods, and apparatus known to one of ordinary skill in the relevant art may not be discussed in detail, but are intended to be part of the specification where appropriate. In all examples shown and discussed herein, any specific values should be construed as merely illustrative, and not a limitation. Thus, other examples of the exemplary embodiments may have different values. It should be noted that: like reference numerals and letters denote like items in the following figures, and thus once an item is defined in one figure, no further discussion thereof is necessary in subsequent figures.

In the description of the present invention, it should be understood that the azimuth or positional relationships indicated by the azimuth terms such as "front, rear, upper, lower, left, right", "lateral, vertical, horizontal", and "top, bottom", etc., are generally based on the azimuth or positional relationships shown in the drawings, merely to facilitate description of the present invention and simplify the description, and these azimuth terms do not indicate and imply that the apparatus or elements referred to must have a specific azimuth or be constructed and operated in a specific azimuth, and thus should not be construed as limiting the scope of protection of the present invention; the orientation word "inner and outer" refers to inner and outer relative to the contour of the respective component itself.

Spatially relative terms, such as "above … …," "above … …," "upper surface at … …," "above," and the like, may be used herein for ease of description to describe one device or feature's spatial location relative to another device or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "above" or "over" other devices or structures would then be oriented "below" or "beneath" the other devices or structures. Thus, the exemplary term "above … …" may include both orientations of "above … …" and "below … …". The device may also be positioned in other different ways (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.

In addition, the terms "first", "second", etc. are used to define the components, and are only for convenience of distinguishing the corresponding components, and the terms have no special meaning unless otherwise stated, and therefore should not be construed as limiting the scope of the present invention.

The invention provides an isolation packaging structure which can isolate and package different preparations and mix the preparations when in use, but the isolation packaging structure in the prior art adopts the traditional injection molding and filling modes, has low efficiency and can not ensure the quality of essence.

The invention uses BFS technique to mold, the BFS technique refers to three-in-one (bottle blowing-filling-sealing) aseptic filling technique, which refers to an advanced technique that completes the molding of packaging containers, the filling of liquid medicine and the sealing of containers in a completely controlled environment on a single machine, and can keep the packaging of medicines and the contents thereof in an aseptic state. Correspondingly, the isolation packaging structure formed by the BFS technology can realize full-automatic packaging, greatly improve the production efficiency and ensure the quality of essence in the forming process.

According to the forming process of the isolation packaging structure, the aseptic filling of essence is achieved by using the BFS technology, and the improvement is carried out on the basis of the aseptic filling, so that the aseptic filling of the built-in double-cavity packaging structure is achieved, the process is used for storing different preparations, and the quality of the essence is guaranteed.

The forming process of the isolation packaging structure of the embodiment comprises the following steps:

s1 provides a first container 1, and as shown in fig. 1, a cavity is formed in the first container 1, and the first container 1 may be purchased directly or manufactured by an extrusion stretch molding method, that is, a heated resin is continuously passed through a die by an extruder and extruded into a product of a desired shape. Or injection molding, namely injecting a thermoplastic plastic solution into a mold under high pressure by using an injection molding machine, and cooling and solidifying to obtain the product. Or blow molding, in which a hollow product is blown from a hot fat parison enclosed in a mold by the pressure of compressed air.

The first container 1 is preferably made of plastic material. In order to facilitate the breaking of the first container 1 to mix the essence stored in isolation, the first container 1 needs to be manufactured into a body with a breaking structure, and the breaking structure of the prior art may be adopted, which is not described herein.

S2, after the first accommodating body 1 is manufactured, the first accommodating body 1 is required to be filled with a first preparation, and the first accommodating body 1 is subjected to sealing treatment, preferably, a coating is manufactured on the inner surface or the outer surface of the first accommodating body 1, so that sealing isolation is ensured, and the first accommodating body 1 is filled for later use after the sealing treatment.

The first container 1 in this embodiment can be produced and sold independently.

According to one embodiment of the invention, the coating process is preferably a PlasmaPlus nanocoating, which is achieved on the inside and outside walls of the package by an innovative low cost PlasmaPlus plasma coating process. The Plasmaplus nano coating is a nano coating developed by Plasmamat, is transparent glass, but has elasticity, impact resistance and friction resistance, and can play a role in blocking and prolong the shelf life of the product. The material of the thin film organic coating of the plasma coating can be selected from, but not limited to, polyethylene, polystyrene, siloxane, fluoropolymer, aminated, hydroxyethyl methacrylate, silane and vinyl.

According to one embodiment of the invention, the coating process is preferably a SideLe Actis coating, deposited on the inside surface of the package by an Actis plasma spray technique. The Sidele Actis coating can play a role in blocking and protecting products in the package, prolong the shelf life of the products and realize the light weight of the package.

According to one embodiment of the invention, the coating process is preferably a DLC diamond like coating, also known as an amorphous carbon coating, which is formed by physical vapor deposition PVD process in a vacuum environment adhering to the surface of the package. The coating is thin and hard, can play a role in barrier protection, has very good machinability, corrosion resistance, high hardness and friction resistance, and can remarkably reduce the conditions of scratch and scratch on the surface of an object.

According to one embodiment of the present invention, the coating process is preferably a Parylene coating, which is a polymer of para-xylene, and the Parylene can be classified into N type, C type, F type, HT type, etc. according to molecular structures, and a completely covered polymer film coating is formed on the surface of the package through a vacuum pyrolysis vapor deposition process. The film coating has extremely thin and uniform thickness, is compact, has no pinholes, is transparent and flexible, does not contain auxiliary agents, does not damage a substrate, has excellent electrical insulation property and barrier property, and is the most effective dampproof, mildew-proof, corrosion-proof and salt mist-proof coating material in the current generation. It can be applied to surfaces of various shapes, including sharp corners, cracks and internal surfaces.

S3, extruding the formed blank by using BFS technology, wherein the existing aseptic filling technology can be directly used, specifically, plastic particles are continuously extruded by a rotating screw rod at the temperature of 170-230 ℃ and the pressure of 350bar to form the formed blank, the formed blank protected by aseptic air passes through a die, when the formed blank reaches the correct length, the main die is closed and the bottom of the formed blank is sealed, a cutter cuts off the formed blank, the top of the formed blank is positioned by an opening retaining clip, and the formed blank opened in the die is continuously protected by aseptic air.

S4, blowing the second container 2 into a second preparation according to the shape of a mould by using BFS technology, and filling the second preparation, wherein the mould is quickly transferred to a blowing/filling station, and sterile air in a class A air shower device of the equipment protects the bottle blowing, filling and sealing station. The blowing and filling needle mechanism is quickly lowered to the neck part of the container, and clean compressed air (vacuum pumping method is adopted for forming small containers) is used for blowing the container according to the shape of the mould; essence metered by time-pressure method is immediately filled in the container and sterile air in the container is removed.

S5, the first container 1 is put into the second container 2.

It should be noted that, as shown in fig. 1 and 4, in this embodiment, the improved blowing and filling mechanism 4 is used to complete three actions of blowing, filling and casting, specifically, the blowing and filling mechanism 4 includes a blowing and filling needle, the blowing and filling needle is communicated with the flow pump through a first branch channel 42, the blowing and filling needle is communicated with a casting device through a second branch channel 43, an air pump is disposed at an end of the blowing and filling needle, and the casting device sends the first container 1 into the blowing and filling needle, and uses the pressure of the air pump to cast and put into the second container 2.

According to one embodiment of the invention, the dispensing device comprises a base 44, a pneumatic push rod 45 fixed on the base 44 and a vibration feeding device 5, wherein a pushing channel for the first container 1 to pass through is formed in the base 44, a feeding channel 47 is formed on one side of the base 44, the feeding channel 47 is connected with the output end of the vibration feeding device 5, the first container 1 is sequentially sent into the pushing channel, then the first container 1 is pushed into a blowing and filling needle by the pneumatic push rod 45, preferably, before the pneumatic push rod 45 acts, a flow pump is started for filling, then the first container 1 is pushed into the blowing and filling needle by the pneumatic push rod 45, after the posture of the first container 1 is adjusted, an air pump 46 is started for pressing the first container 1 to a filling opening, so that the first container 1 and a preparation can simultaneously move downwards, and the first container 1 can be protected by the preparation, so that the first container 1 cannot be directly pressed into the second container 2 to be broken. In addition, in order to pursue the filling speed, the pressure of the flow pump is large, the impact of the preparation on the blowing and filling needle is large, and the pressure of the air pump 46 can skillfully reduce the lateral impact of the preparation on the blowing and filling needle.

According to one embodiment of the invention, the vibratory feeding device 5 comprises a vibratory feeding tray 51 and a transfer channel 52, the vibratory feeding tray 51 feeding the first containers 1 into the feeding channel 47 by means of the transfer channel 52, preferably a first side of the transfer channel 52 being provided with a blowing assembly 53, with which the reject product can be rejected, and a second side of the transfer channel 52 being provided with a deflection guide assembly 54 opposite to the blowing assembly 53.

Specifically, the deflection guiding component 54 includes a deflection arm hinged to the second side of the transfer channel 52 and a guiding roller located at the free end of the deflection arm, a torsion spring is disposed between the deflection arm and the transfer channel 52, and provides a restoring force for the deflection arm, so when the first container 1 is an empty bag body, the air blowing component 53 can easily blow the first container 1 out of the transfer channel 52, after the first container 1 is filled with a preparation, the air blowing component 53 can only change the traveling direction of the first container 1, but cannot blow out of the transfer channel 52, the first container 1 continues to advance and deflects under the action of the guiding roller, the deflected first container 1 is fed into the feeding channel 47, preferably, the feeding channel 47 is obliquely disposed, so that the first container 1 can be orderly fed into the pushing channel by using gravity, further, a movable connection is formed between an outlet of the transfer channel 52 and the feeding channel 47, the transfer channel 52 does not interfere with the up-down movement of the feeding channel 47, the outlet of the transfer channel 52 is further provided with a top block, and the top block limits the first container 1 after the feeding is completed.

The opening time of the container is also ensured to be short in gas delivery, the exposure time of essence is shorter, the period of one filling cycle is less than 13s, the opening time of the container is approximately 2-4 s, and the time from the filling to the sealing of the container is shorter, namely the exposure time of liquid medicine is shorter.

The embodiment integrates a throwing device, a flow pump, an air pump and a blowing and filling needle into an integrated structure, and the throwing device, the flow pump and the air pump move up and down along with the blowing and filling needle at the same time, so that the space utilization of BFS equipment is facilitated.

According to another embodiment of the invention, the first containing body 1 is fed into said first containing body 1 by means of a robot.

S6, packaging the second container body 2 by using BFS technology to form a complete package, wherein in the link, a plastic blank between the top of the plastic mold and the opening retaining clamp is still in a semi-molten state, and then the head mold is combined to form the top of the container, and the second container body 2 is sealed.

After S7 sealing, the mould is opened and the filled and sealed second container 2 is fed out of the machine, and the next cycle is started.

In another aspect of the present invention, an insulation packaging structure is provided, and the insulation packaging structure is manufactured by adopting the above-mentioned insulation packaging structure forming process, where the insulation packaging structure includes a first accommodating body 1 and a second accommodating body 2, and two independent accommodating cavities are formed, the first accommodating body 1 is built in the second accommodating body 2, and a coating is formed on an inner surface and/or an outer surface of the first accommodating body 1.

According to one embodiment of the invention, the coating is made of parylene, the thickness of which is 0.5 μm-1 μm, the parylene having very good barrier properties, the tightness being ensured at a minimum layer thickness.

According to one embodiment of the invention, the first containing body 1 has a diameter of 0.5-1cm, a length of 20-30mm and a wall thickness of 1-2mm.

According to one embodiment of the present invention, the second container 2 contains liquid essence, and the first container 1 contains freeze-dried powder.

According to the isolation packaging structure, the surface of the first accommodating body is coated with the coating, so that the overall permeation resistance of the first accommodating body is improved, and the mutual permeation among different preparations can not occur in the long-term storage process; moreover, the coating can improve the overall strength of the first accommodating body, and the first accommodating body is ensured not to crack in the process of being put into the second accommodating body.

Preferably, the first container 1 of the present embodiment is provided with a breaking structure 3, so that a consumer can break the first container 1 through the second container 2, the breaking structure 3 of the present embodiment adopts a crushing breaking structure, the structure is simple, and the consumer can break the first container 1 conveniently. Specifically, as shown in fig. 3, the rupture structure 3 includes a thinned portion 31 and a dislocated engagement portion 33, wherein the thinned portion 31 forms a thinned line 32 on the first container 1, that is, at least one thinned line 32 exists on the first container 1, and the thickness of the first container 1 on the thinned line 32 is smaller than other portions, so that the first container 1 is easier to deform with the thinned line 32 as a bending point when being pressed; the dislocated engagement portion 33 forms a joint line 34 on the first accommodating body 1, that is, the first accommodating body 1 is formed by dislocating and engaging at least two opening sub-components, and the dislocated engagement portion forms the joint line 34 to seal the first accommodating body 1, so that the first accommodating body 1 deforms with the thinned line 32 as a bending point and cracks at the joint line 34 when being pressed, and the first preparation in the first accommodating body 1 can be mixed with the second preparation in the second accommodating body 2.

Because the first accommodating body 1 is provided with the coating, the coating can cover the cracking structure 3 in the first accommodating body 1 and/or outside, and the overall strength of the first accommodating body 1 is improved, so that in order to more easily and more conveniently and effectively crack the first accommodating body 1, the embodiment adopts the cracking structure 3 comprising the thinning part 31 and the dislocation clamping part 33, when being pressed, the thinning part 31 is easier to deform as a bending point and crack at the dislocation clamping part 33, if only the dislocation clamping part 33 is adopted, although the dislocation clamping part 33 can easily generate dislocation, a user generally needs to press the dislocation clamping part 33 to easily crack the first accommodating body 1, and in order to more easily crack the dislocation clamping part 33, the embodiment simultaneously sets the thinning part 31, and the dislocation clamping part 33 is easier to move, no matter the thinning part 31 is the dislocation clamping part 33, the first accommodating body 1 can be cracked, that is not required to be easily cracked at a specific position, and the user can more conveniently and conveniently hold the first accommodating body 1 from any position. In addition, the rupture structure 3 of this embodiment is simple in structure, and does not require a complex puncturing device such as a blade or a needle.

Preferably, the first container 1 is provided in a cylindrical shape with hemispherical ends, the diameters of the cylindrical body and the hemispheres at the two ends are 5-10mm, the overall length of the first container 1 is 20-30mm, and the wall thickness is 1-2mm. The dislocating engagement portion 33 forms a closed and sealed engagement line 34 along the longitudinal extension of the first container 1, that is, the first container 1 is formed by dislocating engagement of the two first sub-containers 12, and the engagement structure of the two first sub-containers 12 is optionally but not limited to an interference fit or a structure of providing a protrusion and a groove engagement, and since the engagement line 34 extends along the longitudinal direction of the first container 1, the area of a fracture surface formed by the first container 1 after being broken under pressure is maximized, and the first preparation in the two first sub-containers 12 can be mixed with the second preparation in the second container 2 more quickly and sufficiently.

Further, the thinned portion 31 of the present embodiment also extends in the longitudinal direction of the first container 1 to form a closed thinned line 32, and since the above-described bonding line 34 extends in the longitudinal direction of the first container 1, if the thinned line 32 is provided to extend in the transverse direction of the first container 1, i.e., in the direction perpendicular to the longitudinal direction, the first container 1 is opened at the bonding line 34 position mainly at both ends of the first container 1 with the thinned line 32 as the intermediate point when being pressed, the deformation amount of the deformation is small, and the opening area is small. In the present embodiment, the thin line 32 extends along the longitudinal direction of the first accommodating body 1, and when the first accommodating body 1 is pressed, the thin line 32 is taken as a middle point to be mainly opened at the position of the bonding line 34 at the side wall of the first accommodating body 1, so that the deformation amount of deformation is large, and the opening area is large. Most preferably, the present embodiment provides that the bonding wire 34 intersects with the thinning wire 32 at both ends of the first container 1 and is perpendicular, so that the first container 1 can be easily broken when any position between the thinning wire 32 and the bonding wire 34 is forced.

As shown in fig. 3, the thinned portion 31 of the present embodiment is formed on the inner surface of the first container 1, and the thinned portion 31 is formed in a groove shape, and the specific shape of the groove is selected from but not limited to triangle, rectangle, arc, etc., preferably triangle. Further, the misalignment engaging portion 33 of the present embodiment includes an outer protruding portion and an inner protruding portion that are engaged with each other, specifically, an outer protruding portion and an inner protruding portion are formed from the outside to the inside at the edge of one of the first sub-containers 12 (the upper one in fig. 3), an inner protruding portion and an outer protruding portion are formed from the outside to the inside at the edge of the other first sub-container 12 (the lower one in fig. 3), and the joint surface between the outer protruding portion of each first sub-container 12 and the inner protruding portion thereof is formed as an inclined surface 13 from the inside to the outside at the edge, so that when the first container 1 is pressed, the misalignment between the two first sub-containers 12 is more likely to occur under the guidance of the inclined surface 13, thereby making the first container 1 more likely to be pinched.

The present invention is not limited to the above-mentioned embodiments, and any person skilled in the art, based on the technical solution of the present invention and the inventive concept thereof, can be replaced or changed within the scope of the present invention.

Claims

1. The forming process of the isolation packaging structure is characterized by comprising the following steps of:

providing a first receiving body (1),

filling a first preparation in the first accommodating body (1), and sealing the first accommodating body (1);

extruding the formed blank by BFS technology;

blowing a second container (2) according to the shape of the mould by using BFS technology and filling a second preparation;

-inserting the first containing body (1) into the second containing body (2);

encapsulating the second containing body (2) by BFS technology to form a complete package;

after sealing, the mould is opened to send out the package.

2. The process for forming the insulation package structure according to claim 1, wherein a coating is made on the surface of the first container body (1), wherein the coating is located on the inner surface and/or the outer surface of the first container body (1).

3. The process for forming the insulation package structure according to claim 1, wherein a coating is formed on the surface of the first container body (1), the coating is formed by a plasma coating process, and the material of the thin film organic coating of the plasma coating is polyethylene, polystyrene, siloxane, fluorine-containing polymer, amination, hydroxyethyl methacrylate, silane or vinyl.

4. The process for forming the insulation package structure according to claim 1, wherein a coating is made on the surface of the first container body (1), and the coating process is a sildenal action coating, a DLC coating or a Parylene coating.

5. The process for forming the isolation packaging structure according to claim 1, wherein the second preparation is filled by using a blowing and filling mechanism (4) and then the first accommodating body (1) is put in, the blowing and filling mechanism (4) comprises a blowing and filling needle, the blowing and filling needle is communicated with the flow pump through a first branch channel (42), the blowing and filling needle is communicated with a putting device through a second branch channel (43), the end part of the blowing and filling needle is provided with an air pump (46), and the putting device sends the first accommodating body (1) into the blowing and filling needle and puts the first accommodating body (1) into the second accommodating body (2) by using the pressure of the air pump (46).

6. The process for forming the insulation package according to claim 1, wherein the second preparation is filled by means of a blow-filling mechanism (4) and then the first containing body (1) is fed into the second containing body (2) by means of a robot.

7. The barrier packaging structure forming process of claim 1, wherein the first formulation is a solid or a liquid and the second formulation is a liquid.

8. The isolation packaging structure is manufactured by adopting the isolation packaging structure forming process according to any one of claims 1-7, and is characterized by comprising a first accommodating body (1) and a second accommodating body (2) and forming two independent accommodating cavities, wherein the first accommodating body (1) is internally arranged in the second accommodating body (2), and a coating is formed on the inner surface and/or the outer surface of the first accommodating body (1).

9. The barrier packaging structure of claim 8, wherein the coating is made of parylene, and the thickness of the coating is 0.5 μm to 1 μm.

10. The insulation package according to claim 8, wherein the first container (1) has a diameter of 0.5-1cm, a length of 20-30mm and a wall thickness of 1-2mm.

11. The isolation packaging structure according to claim 8, wherein the second container (2) contains liquid essence, and the first container (1) contains freeze-dried powder.